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Reprogramming induced neurons from olfactory ensheathing glial cells: A feasible approach for spinal cord injury repair
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作者 Javier Sierra María Portela-Lomba +1 位作者 Diana Simón M.Teresa Moreno-Flores 《Neural Regeneration Research》 2026年第1期296-297,共2页
Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disruptin... Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons. 展开更多
关键词 INJURY feasible programming
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Quality-guaranteed Dubins Path Planning for USV Based on Mixed-integer Piecewise linear Programming for Addressing the Extended Minimum-time Intercept Problem
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作者 Xing Zhou Kelin Zhu +3 位作者 Shuang Liu Zhaoqing Li Wenxin Zhang Kang Du 《哈尔滨工程大学学报(英文版)》 2026年第1期216-227,共12页
During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive... During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive distance)to a moving target as quickly as possible,resulting in the extended minimum-time intercept problem(EMTIP).Existing research has primarily focused on the zero-distance intercept problem,MTIP,establishing the necessary or sufficient conditions for MTIP optimality,and utilizing analytic algorithms,such as root-finding algorithms,to calculate the optimal solutions.However,these approaches depend heavily on the properties of the analytic algorithm,making them inapplicable when problem settings change,such as in the case of a positive effective range or complicated target motions outside uniform rectilinear motion.In this study,an approach employing a high-accuracy and quality-guaranteed mixed-integer piecewise-linear program(QG-PWL)is proposed for the EMTIP.This program can accommodate different effective interception ranges and complicated target motions(variable velocity or complicated trajectories).The high accuracy and quality guarantees of QG-PWL originate from elegant strategies such as piecewise linearization and other developed operation strategies.The approximate error in the intercept path length is proved to be bounded to h^(2)/(4√2),where h is the piecewise length. 展开更多
关键词 Minimum-time intercept problem Dubins vehicle Mixed-integer piecewise-linear program LINEARIZATION Approximate error trigonometric function USV
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Multiple-constraint cooperative guidance based on two-stage sequential convex programming 被引量:16
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作者 Wei DONG Qiuqiu WEN +1 位作者 Qunli XIA Shengjiang YANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2020年第1期296-307,共12页
An improved approach is presented in this paper to implement highly constrained cooperative guidance to attack a stationary target.The problem with time-varying Proportional Navigation(PN)gain is first formulated as a... An improved approach is presented in this paper to implement highly constrained cooperative guidance to attack a stationary target.The problem with time-varying Proportional Navigation(PN)gain is first formulated as a nonlinear optimal control problem,which is difficult to solve due to the existence of nonlinear kinematics and nonconvex constraints.After convexification treatments and discretization,the solution to the original problem can be approximately obtained by solving a sequence of Second-Order Cone Programming(SOCP)problems,which can be readily solved by state-of-the-art Interior-Point Methods(IPMs).To mitigate the sensibility of the algorithm on the user-provided initial profile,a Two-Stage Sequential Convex Programming(TSSCP)method is presented in detail.Furthermore,numerical simulations under different mission scenarios are conducted to show the superiority of the proposed method in solving the cooperative guidance problem.The research indicated that the TSSCP method is more tractable and reliable than the traditional methods and has great potential for real-time processing and on-board implementation. 展开更多
关键词 CONVEX optimization Cooperative GUIDANCE GUIDANCE Multiple constraints Second-order cone programming SEQUENTIAL CONVEX programming
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New partial cooperation model for bilevel programming problems 被引量:4
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作者 Shihui Jia Zhongping Wan +1 位作者 Yuqiang Feng Guangmin Wang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第2期263-266,共4页
Partial cooperation models are studied for many years to solve the bilevel programming problems where the follower’s optimal reaction is not unique. However, in these existed models, the follower’s cooperation level... Partial cooperation models are studied for many years to solve the bilevel programming problems where the follower’s optimal reaction is not unique. However, in these existed models, the follower’s cooperation level does not depend on the leader’s decision. A new model is proposed to solve this deficiency. It is proved the feasibility of the new model when the reaction set of the lower level is lower semicontinuous. And the numerical results show that the new model has optimal solutions when the reaction set of the lower level is discrete, lower semi-continuous and non-lower semi-continuous. 展开更多
关键词 bilevel programming reaction set optimistic model pessimistic model partial cooperation model cooperation level.
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Sequential quadratic programming-based non-cooperative target distributed hybrid processing optimization method 被引量:3
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作者 SONG Xiaocheng WANG Jiangtao +3 位作者 WANG Jun SUN Liang FENG Yanghe LI Zhi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2023年第1期129-140,共12页
The distributed hybrid processing optimization problem of non-cooperative targets is an important research direction for future networked air-defense and anti-missile firepower systems. In this paper, the air-defense ... The distributed hybrid processing optimization problem of non-cooperative targets is an important research direction for future networked air-defense and anti-missile firepower systems. In this paper, the air-defense anti-missile targets defense problem is abstracted as a nonconvex constrained combinatorial optimization problem with the optimization objective of maximizing the degree of contribution of the processing scheme to non-cooperative targets, and the constraints mainly consider geographical conditions and anti-missile equipment resources. The grid discretization concept is used to partition the defense area into network nodes, and the overall defense strategy scheme is described as a nonlinear programming problem to solve the minimum defense cost within the maximum defense capability of the defense system network. In the solution of the minimum defense cost problem, the processing scheme, equipment coverage capability, constraints and node cost requirements are characterized, then a nonlinear mathematical model of the non-cooperative target distributed hybrid processing optimization problem is established, and a local optimal solution based on the sequential quadratic programming algorithm is constructed, and the optimal firepower processing scheme is given by using the sequential quadratic programming method containing non-convex quadratic equations and inequality constraints. Finally, the effectiveness of the proposed method is verified by simulation examples. 展开更多
关键词 non-cooperative target distributed hybrid processing multiple constraint minimum defense cost sequential quadratic programming
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New partial cooperation model for ill-posed bilevel programming problem via satisfactory degree 被引量:1
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作者 Shihui Jia Zhongping Wan Xuhui Xia 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第1期177-182,共6页
Partial cooperation formulation is a more viable option than optimistic's and pessimistic's to solve an ill-posed bilevel programming problem.Aboussoror's partial cooperation model uses a constant as a cooperation ... Partial cooperation formulation is a more viable option than optimistic's and pessimistic's to solve an ill-posed bilevel programming problem.Aboussoror's partial cooperation model uses a constant as a cooperation index to describe the degree of follower's cooperation.The constant only indicates the leader's expectation coefficient for the follower's action,not the follower's own willingness.To solve this situation,a new model is proposed by using the follower's satisfactory degree as the cooperation degree.Then,because this new cooperation degree is a function which is dependent on the leader's choice and decided by the follower's satisfactory degree,this paper proves such proposed model not only leads an optimal value between the optimistic value and pessimistic's,but also leads a more satisfactory solution than Aboussoror's.Finally,a numerical experiment is given to demonstrate the feasibility of this new model. 展开更多
关键词 bilevel programming partial cooperation cooperation degree satisfactory degree intermediate solution.
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A Cooperation-planning Model Based on Bilevel Programming Decision 被引量:1
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作者 ZHANG Jianfeng ZHOU Lei +2 位作者 BAO Zhenqiang BIAN Wenyu LI Xiangqing 《武汉理工大学学报》 CAS CSCD 北大核心 2006年第S3期940-945,共6页
This paper is based on a resource constrained active network project;the constraint of the local resource and the time constraint of the cooperation resource are considered simultaneously.And the respective benefit of... This paper is based on a resource constrained active network project;the constraint of the local resource and the time constraint of the cooperation resource are considered simultaneously.And the respective benefit of the manager and cooperation partners is also considered simultaneously.And a cooperation planning model based on bilevel multi-objective programming is de-signed,according to the due time and total cost.And an extended CNP based on the permitted range for resource and time requests is presented.A larger task set in scheduling cycle is on the permitting for the request of cooperation resource and time while the task manager itself may be permitted biding for tasks.As a result,the optimization space for the cooperation planning is enlarged.So not every bidding task is successfully bid by invitee,and the task manager itself takes on some bidding tasks.Finally,the genetic algorithm is given and the validity and feasibility of the model is proved by a case. 展开更多
关键词 bilevel programming decision cooperation planning genetic algorithm range for resource and time sequest
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基于探究式MOOP实训的混合式教学研究——以程序设计翻转课堂为例
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作者 蒋杰 魏迎梅 周秉泉 《教育教学论坛》 2025年第37期119-123,共5页
在数字化时代背景下,程序设计能力已成为计算机科学领域及其他专业学生的必备技能。它对于培养学生的逻辑思维、问题解决能力和创新思维至关重要。程序设计课程不仅教授学生技术知识,更重要的是通过实践来提升学生的编程实操能力。然而... 在数字化时代背景下,程序设计能力已成为计算机科学领域及其他专业学生的必备技能。它对于培养学生的逻辑思维、问题解决能力和创新思维至关重要。程序设计课程不仅教授学生技术知识,更重要的是通过实践来提升学生的编程实操能力。然而,传统的教学模式存在诸多局限,包括理论与实践脱节、缺乏有效的编程评判系统和难易度设计,以及学生编程兴趣的逐渐丧失。为了解决这些问题,提出了利用大型在线实践平台(MOOP)的混合式教学框架。该框架结合了翻转课堂、阶梯式编程训练、阶段性编程测试和教师助教的日常反馈,旨在显著提升学生的编程能力。 展开更多
关键词 Moop 混合式教学 翻转课堂 程序设计 项目实践
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游戏引擎与OOP技术支撑下教育游戏的交互设计与用户体验研究
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作者 徐东霞 《电脑知识与技术》 2025年第28期102-104,112,共4页
面向对象编程一般指面向对象程序设计,在提升代码可重用性、模块化与可维护性方面作用显著。针对当前教育游戏交互设计缺乏系统性技术支撑、用户体验评估不足等问题,文章提出了一套基于游戏引擎与OOP技术的模块化交互设计框架。该框架... 面向对象编程一般指面向对象程序设计,在提升代码可重用性、模块化与可维护性方面作用显著。针对当前教育游戏交互设计缺乏系统性技术支撑、用户体验评估不足等问题,文章提出了一套基于游戏引擎与OOP技术的模块化交互设计框架。该框架通过对引擎功能的接口化封装和交互对象的继承体系设计,实现了高效、可复用的交互逻辑。通过用户测试与问卷分析,验证了该框架能显著提升学习者的沉浸感与操作效率。该研究为构建兼具教育性与高用户体验的教育游戏提供了系统性的技术实现与评估策略。 展开更多
关键词 教育游戏 游戏引擎 oop技术 交互设计 用户体验
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Glia-to-neuron reprogramming to the rescue?
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作者 Jack W.Hickmott Cindi M.Morshead 《Neural Regeneration Research》 SCIE CAS 2025年第5期1395-1396,共2页
Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells c... Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state. 展开更多
关键词 programming PASSING PROOF
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Neurocircuit regeneration by extracellular matrix reprogramming
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作者 Shengzhang Su Ian N.Levasseur Kimberly M.Alonge 《Neural Regeneration Research》 SCIE CAS 2025年第8期2300-2301,共2页
The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functio... The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases. 展开更多
关键词 MATRIX programming
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Safe flight corridor constrained sequential convex programming for efficient trajectory generation of fixed-wing UAVs 被引量:2
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作者 Jing SUN Guangtong XU +2 位作者 Zhu WANG Teng LONG Jingliang SUN 《Chinese Journal of Aeronautics》 2025年第1期537-550,共14页
Generating dynamically feasible trajectory for fixed-wing Unmanned Aerial Vehicles(UAVs)in dense obstacle environments remains computationally intractable.This paper proposes a Safe Flight Corridor constrained Sequent... Generating dynamically feasible trajectory for fixed-wing Unmanned Aerial Vehicles(UAVs)in dense obstacle environments remains computationally intractable.This paper proposes a Safe Flight Corridor constrained Sequential Convex Programming(SFC-SCP)to improve the computation efficiency and reliability of trajectory generation.SFC-SCP combines the front-end convex polyhedron SFC construction and back-end SCP-based trajectory optimization.A Sparse A^(*)Search(SAS)driven SFC construction method is designed to efficiently generate polyhedron SFC according to the geometric relation among obstacles and collision-free waypoints.Via transforming the nonconvex obstacle-avoidance constraints to linear inequality constraints,SFC can mitigate infeasibility of trajectory planning and reduce computation complexity.Then,SCP casts the nonlinear trajectory optimization subject to SFC into convex programming subproblems to decrease the problem complexity.In addition,a convex optimizer based on interior point method is customized,where the search direction is calculated via successive elimination to further improve efficiency.Simulation experiments on dense obstacle scenarios show that SFC-SCP can generate dynamically feasible safe trajectory rapidly.Comparative studies with state-of-the-art SCP-based methods demonstrate the efficiency and reliability merits of SFC-SCP.Besides,the customized convex optimizer outperforms off-the-shelf optimizers in terms of computation time. 展开更多
关键词 Fixed-wing unmanned aerial vehicle Efficient trajectory planning Safe flight corridor Sequential convex programming Customized convex optimizer
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Programming ferromagnetic soft materials for miniature soft robots:Design,fabrication,and applications 被引量:1
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作者 Junliang Chen Dongdong Jin +1 位作者 Qianqian Wang Xing Ma 《Journal of Materials Science & Technology》 2025年第16期271-287,共17页
Due to the small size,active mobility,and intrinsic softness,miniature soft robots hold promising po-tentials in reaching the deep region inside living bodies otherwise inaccessible with compelling agility,adaptabilit... Due to the small size,active mobility,and intrinsic softness,miniature soft robots hold promising po-tentials in reaching the deep region inside living bodies otherwise inaccessible with compelling agility,adaptability and safety.Various materials and actuation strategies have been developed for creating soft robots,among which,ferromagnetic soft materials that self-actuate in response to external magnetic fields have attracted worldwide attention due to their remote controllability and excellent compatibil-ity with biological tissues.This review presents comprehensive and systematic research advancements in the design,fabrication,and applications of ferromagnetic soft materials for miniature robots,providing in-sights into their potential use in biomedical fields and beyond.The programming strategies of ferromag-netic soft materials are summarized and classified,including mold-assisted programming,3D printing-assisted programming,microassembly-assisted programming,and magnetization reprogramming.Each approach possesses unique advantages in manipulating the magnetic responsiveness of ferromagnetic soft materials to achieve outstanding actuation and deformation performances.We then discuss the biomedi-cal applications of ferromagnetic soft material-based soft robots(e.g.,minimally invasive surgery,targeted delivery,and tissue engineering),highlighting their potentials in revolutionizing biomedical technologies.This review also points out the current challenges and provides insights into future research directions,which we hope can serve as a useful reference for the development of next-generation adaptive miniature robots. 展开更多
关键词 Ferromagnetic soft materials Miniature soft robots Magnetic actuation Magnetization programming strategies Biomedical applications
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Residential Energy Scheduling With Solar Energy Based on Dyna Adaptive Dynamic Programming 被引量:1
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作者 Kang Xiong Qinglai Wei Hongyang Li 《IEEE/CAA Journal of Automatica Sinica》 2025年第2期403-413,共11页
Learning-based methods have become mainstream for solving residential energy scheduling problems. In order to improve the learning efficiency of existing methods and increase the utilization of renewable energy, we pr... Learning-based methods have become mainstream for solving residential energy scheduling problems. In order to improve the learning efficiency of existing methods and increase the utilization of renewable energy, we propose the Dyna actiondependent heuristic dynamic programming(Dyna-ADHDP)method, which incorporates the ideas of learning and planning from the Dyna framework in action-dependent heuristic dynamic programming. This method defines a continuous action space for precise control of an energy storage system and allows online optimization of algorithm performance during the real-time operation of the residential energy model. Meanwhile, the target network is introduced during the training process to make the training smoother and more efficient. We conducted experimental comparisons with the benchmark method using simulated and real data to verify its applicability and performance. The results confirm the method's excellent performance and generalization capabilities, as well as its excellence in increasing renewable energy utilization and extending equipment life. 展开更多
关键词 Adaptive dynamic programming(ADP) dynamic residential scenarios optimal residential energy management smart grid
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Evaluation of Integer Programming Solvers to Improve the Efficiency of Individual Work Planning
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作者 Keiichi Takahashi 《Open Journal of Modelling and Simulation》 2025年第1期51-64,共14页
This study proposes a novel approach to optimizing individual work schedules for book digitization using mixed-integer programming (MIP). By leveraging the power of MIP solvers, we aimed to minimize the overall digiti... This study proposes a novel approach to optimizing individual work schedules for book digitization using mixed-integer programming (MIP). By leveraging the power of MIP solvers, we aimed to minimize the overall digitization time while considering various constraints and process dependencies. The book digitization process involves three key steps: cutting, scanning, and binding. Each step has specific requirements and limitations such as the number of pages that can be processed simultaneously and potential bottlenecks. To address these complexities, we formulate the problem as a one-machine job shop scheduling problem with additional constraints to capture the unique characteristics of book digitization. We conducted a series of experiments to evaluate the performance of our proposed approach. By comparing the optimized schedules with the baseline approach, we demonstrated significant reductions in the overall processing time. In addition, we analyzed the impact of different weighting schemes on the optimization results, highlighting the importance of identifying and prioritizing critical processes. Our findings suggest that MIP-based optimization can be a valuable tool for improving the efficiency of individual work schedules, even in seemingly simple tasks, such as book digitization. By carefully considering specific constraints and objectives, we can save time and leverage resources by carefully considering specific constraints and objectives. 展开更多
关键词 Mixed Integer programming Scheduling Optimization Work Planning Book Scanning Gantt Chart
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Research on Human-Computer Collaboration Paradigm in AIGC-Empowered High-Level Language Programming Courses
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作者 Hongyuan Wang Baokai Zu +2 位作者 Yafang Li Wanting Zhu Hongli Chen 《Journal of Contemporary Educational Research》 2025年第5期285-289,共5页
With the rapid development of artificial intelligence technology,AIGC(Artificial Intelligence-Generated Content)has triggered profound changes in the field of high-level language programming courses.This paper deeply ... With the rapid development of artificial intelligence technology,AIGC(Artificial Intelligence-Generated Content)has triggered profound changes in the field of high-level language programming courses.This paper deeply explored the application principles,advantages,and limitations of AIGC in intelligent code generation,analyzed the new mode of human-computer collaboration in high-level language programming courses driven by AIGC,discussed the impact of human-computer collaboration on programming efficiency and code quality through practical case studies,and looks forward to future development trends.This research aims to provide theoretical and practical guidance for high-level language programming courses and promote innovative development of high-level language programming courses under the human-computer collaboration paradigm. 展开更多
关键词 Human-computer collaboration AIGC High-level language programming Intelligence programming Efficiency improvement
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A 28 nm 576K RRAM-based computing-in-memory macro featuring hybrid programming with area efficiency of 2.82 TOPS/mm^(2)
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作者 Siqi Liu Songtao Wei +7 位作者 Peng Yao Dong Wu Lu Jie Sining Pan Jianshi Tang Bin Gao He Qian Huaqiang Wu 《Journal of Semiconductors》 2025年第6期112-119,共8页
Computing-in-memory(CIM)has been a promising candidate for artificial-intelligent applications thanks to the absence of data transfer between computation and storage blocks.Resistive random access memory(RRAM)based CI... Computing-in-memory(CIM)has been a promising candidate for artificial-intelligent applications thanks to the absence of data transfer between computation and storage blocks.Resistive random access memory(RRAM)based CIM has the advantage of high computing density,non-volatility as well as high energy efficiency.However,previous CIM research has predominantly focused on realizing high energy efficiency and high area efficiency for inference,while little attention has been devoted to addressing the challenges of on-chip programming speed,power consumption,and accuracy.In this paper,a fabri-cated 28 nm 576K RRAM-based CIM macro featuring optimized on-chip programming schemes is proposed to address the issues mentioned above.Different strategies of mapping weights to RRAM arrays are compared,and a novel direct-current ADC design is designed for both programming and inference stages.Utilizing the optimized hybrid programming scheme,4.67×programming speed,0.15×power saving and 4.31×compact weight distribution are realized.Besides,this macro achieves a normalized area efficiency of 2.82 TOPS/mm2 and a normalized energy efficiency of 35.6 TOPS/W. 展开更多
关键词 computing-in-memory on-chip programming scheme hybrid programming resistive random access memory matrix-vector-multiplication acceleration
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Adapting High-Level Language Programming(C Language)Education in the Era of Large Language Models
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作者 Baokai Zu Hongyuan Wang +1 位作者 Hongli Chen Yafang Li 《Journal of Contemporary Educational Research》 2025年第5期264-269,共6页
With the widespread application of large language models(LLMs)in natural language processing and code generation,traditional High-Level Language Programming courses are facing unprecedented challenges and opportunitie... With the widespread application of large language models(LLMs)in natural language processing and code generation,traditional High-Level Language Programming courses are facing unprecedented challenges and opportunities.As a core programming language for computer science majors,C language remains irreplaceable due to its foundational nature and engineering adaptability.This paper,based on the rapid development of large model technologies,proposes a systematic reform design for C language teaching,focusing on teaching objectives,content structure,teaching methods,and evaluation systems.The article suggests a teaching framework centered on“human-computer collaborative programming,”integrating prompt training,AI-assisted debugging,and code generation analysis,aiming to enhance students’problem modeling ability,programming expression skills,and AI collaboration literacy. 展开更多
关键词 Large language models(LLMs) High-level language programming C language Human-computer collaborative programming
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From flying dreams to programming pioneer
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作者 孙启禄 《疯狂英语(新读写)》 2025年第7期24-27,76,共5页
More than seventy years before airplanes were invented,a twelve⁃year⁃old girl named Ada Lovelace dreamed of flying.She studied birds and experimented with materials to make wings,even writing a guide called Flyology.B... More than seventy years before airplanes were invented,a twelve⁃year⁃old girl named Ada Lovelace dreamed of flying.She studied birds and experimented with materials to make wings,even writing a guide called Flyology.But her curiosity didnt stop there. 展开更多
关键词 GUIDE flyology ada lovelace programming pioneer FLYING
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