A mathematical program is proposed for the highly nonlinear problem involving frictional contact. A program-pattern using the fast multipole boundary element method (FM- BEM) is given for 3-D elastic contact with fric...A mathematical program is proposed for the highly nonlinear problem involving frictional contact. A program-pattern using the fast multipole boundary element method (FM- BEM) is given for 3-D elastic contact with friction to replace the Monte Carlo method. A new optimized generalized minimal residual (GMRES) algorithm is presented. Numerical examples demonstrate the validity of the program-pattern optimization model for node-to-surface contact with friction. The GMRES algorithm greatly improves the computational efciency.展开更多
背景:骨相关细胞程序性死亡与临床上常见的骨相关疾病(如骨质疏松、骨关节炎)密切相关,中药骨碎补总黄酮可用于调控骨相关细胞程序性死亡,并且具有多靶点调控、毒性低等特点。目的:综述中药骨碎补总黄酮调控骨相关细胞程序性死亡机制的...背景:骨相关细胞程序性死亡与临床上常见的骨相关疾病(如骨质疏松、骨关节炎)密切相关,中药骨碎补总黄酮可用于调控骨相关细胞程序性死亡,并且具有多靶点调控、毒性低等特点。目的:综述中药骨碎补总黄酮调控骨相关细胞程序性死亡机制的研究进展。方法:由第一作者在中国知网、维普数据库、万方数据库和PubMed、Web of Science数据库进行检索,英文检索词为“total flavonoids of rhizoma drynariae,naringin,naringenin,luteolin,kaempferol,programmed cell death,bone,cell”,中文检索词为“骨碎补总黄酮,柚皮素,柚皮苷,木犀草素,山柰酚,程序性死亡,骨,细胞”。根据纳入与排除标准,最终纳入72篇文献进行综述。结果与结论:骨碎补总黄酮通过影响磷脂酰肌醇3激酶/蛋白激酶B、Wnt/β-catenin和沉默信息调节因子3/叉头蛋白O3a等多种信号通路和分子表达降低间充质干细胞、成骨细胞和软骨细胞的死亡率,提高破骨细胞死亡率,纠正骨稳态失衡及软骨退变,为骨相关疾病的治疗提供了新视角。未来可以整合不同组学及测序等技术,系统解析骨碎补总黄酮调控骨相关细胞程序性死亡的分子网络,探讨骨碎补总黄酮多靶点、多途径的治疗作用机制,为骨相关疾病的治疗提供全新思路与方法。展开更多
基金Project supported by the National Natural Science Foundation of China(No.50075075).
文摘A mathematical program is proposed for the highly nonlinear problem involving frictional contact. A program-pattern using the fast multipole boundary element method (FM- BEM) is given for 3-D elastic contact with friction to replace the Monte Carlo method. A new optimized generalized minimal residual (GMRES) algorithm is presented. Numerical examples demonstrate the validity of the program-pattern optimization model for node-to-surface contact with friction. The GMRES algorithm greatly improves the computational efciency.
文摘背景:骨相关细胞程序性死亡与临床上常见的骨相关疾病(如骨质疏松、骨关节炎)密切相关,中药骨碎补总黄酮可用于调控骨相关细胞程序性死亡,并且具有多靶点调控、毒性低等特点。目的:综述中药骨碎补总黄酮调控骨相关细胞程序性死亡机制的研究进展。方法:由第一作者在中国知网、维普数据库、万方数据库和PubMed、Web of Science数据库进行检索,英文检索词为“total flavonoids of rhizoma drynariae,naringin,naringenin,luteolin,kaempferol,programmed cell death,bone,cell”,中文检索词为“骨碎补总黄酮,柚皮素,柚皮苷,木犀草素,山柰酚,程序性死亡,骨,细胞”。根据纳入与排除标准,最终纳入72篇文献进行综述。结果与结论:骨碎补总黄酮通过影响磷脂酰肌醇3激酶/蛋白激酶B、Wnt/β-catenin和沉默信息调节因子3/叉头蛋白O3a等多种信号通路和分子表达降低间充质干细胞、成骨细胞和软骨细胞的死亡率,提高破骨细胞死亡率,纠正骨稳态失衡及软骨退变,为骨相关疾病的治疗提供了新视角。未来可以整合不同组学及测序等技术,系统解析骨碎补总黄酮调控骨相关细胞程序性死亡的分子网络,探讨骨碎补总黄酮多靶点、多途径的治疗作用机制,为骨相关疾病的治疗提供全新思路与方法。
