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Publisher Correction:Explicit modeling of mechanical property of hot-rolled strip steel based on data-driven and gene expression programming
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作者 Li Wang Qi-ning Zhu +2 位作者 Shun-hu Zhang Lei Zhang Jin-ping Zhang 《Journal of Iron and Steel Research International》 2025年第12期4531-4531,共1页
Correction to:J.Iron Steel Res.Int.https://doi.org/10.1007/s42243-025-01545-x The publication of this article unfortunately contained mistakes.Equation(14)was not correct.The corrected equation is given below.
关键词 mechanical property data driven hot rolled strip steel gene expression programming
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Predicting the minimum horizontal principal stress using genetic expression programming and borehole breakout data
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作者 Rui Zhang Jian Zhou 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第7期4227-4240,共14页
As a critical component of the in situ stress state,determination of the minimum horizontal principal stress plays a significant role in both geotechnical and petroleum engineering.To this end,a gene expression progra... As a critical component of the in situ stress state,determination of the minimum horizontal principal stress plays a significant role in both geotechnical and petroleum engineering.To this end,a gene expression programming(GEP)algorithm-based model,in which the data of borehole breakout size,vertical principal stress,and rock strength characteristics are used as the inputs,is proposed to predict the minimum horizontal principal stress.Seventy-nine(79)samples with seven features are collected to construct the minimum horizontal principal stress dataset used for training models.Twenty-four(24)GEP model hyperparameter sets were configured to explore the key parameter combinations among the inputs and their potential relationships with the minimum horizontal principal stresses.Model performance was evaluated using root mean squared error(RMSE),mean absolute error(MAE),mean absolute percentage error(MAPE),and coefficient of determination(R^(2)).By comparing predictive performance and parameter composition,two models were selected from 24 GEP models that demonstrated excellent predictive performance and simpler parameter composition.Compared with prevalent models,the results indicate that the two selected GEP models have better performance on the test set(R^(2)=0.9568 and 0.9621).Additionally,the results conducted by SHapley Additive exPlanations(SHAP)sensitivity analysis and Local Interpretable Model-agnostic Explanations(LIME)demonstrate that the vertical principal stress is the most influential parameter in both GEP models.The two GEP models have simple parameter compositions as well as stable and excellent prediction performance,which is a viable method for predicting the minimum horizontal principal stresses. 展开更多
关键词 gene expression programming(GEP) In situ stresses Minimum horizontal principal stresses Borehole breakout
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Advanced Machine Learning and Gene Expression Programming Techniques for Predicting CO_(2)-Induced Alterations in Coal Strength
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作者 Zijian Liu Yong Shi +3 位作者 ChuanqiLi Xiliang Zhang Jian Zhou Manoj Khandelwal 《Computer Modeling in Engineering & Sciences》 2025年第4期153-183,共31页
Given the growing concern over global warming and the critical role of carbon dioxide(CO_(2))in this phenomenon,the study of CO_(2)-induced alterations in coal strength has garnered significant attention due to its im... Given the growing concern over global warming and the critical role of carbon dioxide(CO_(2))in this phenomenon,the study of CO_(2)-induced alterations in coal strength has garnered significant attention due to its implications for carbon sequestration.A large number of experiments have proved that CO_(2) interaction time(T),saturation pressure(P)and other parameters have significant effects on coal strength.However,accurate evaluation of CO_(2)-induced alterations in coal strength is still a difficult problem,so it is particularly important to establish accurate and efficient prediction models.This study explored the application of advancedmachine learning(ML)algorithms and Gene Expression Programming(GEP)techniques to predict CO_(2)-induced alterations in coal strength.Sixmodels were developed,including three metaheuristic-optimized XGBoost models(GWO-XGBoost,SSA-XGBoost,PO-XGBoost)and three GEP models(GEP-1,GEP-2,GEP-3).Comprehensive evaluations using multiple metrics revealed that all models demonstrated high predictive accuracy,with the SSA-XGBoost model achieving the best performance(R2—Coefficient of determination=0.99396,RMSE—Root Mean Square Error=0.62102,MAE—Mean Absolute Error=0.36164,MAPE—Mean Absolute Percentage Error=4.8101%,RPD—Residual Predictive Deviation=13.4741).Model interpretability analyses using SHAP(Shapley Additive exPlanations),ICE(Individual Conditional Expectation),and PDP(Partial Dependence Plot)techniques highlighted the dominant role of fixed carbon content(FC)and significant interactions between FC and CO_(2) saturation pressure(P).Theresults demonstrated that the proposedmodels effectively address the challenges of CO_(2)-induced strength prediction,providing valuable insights for geological storage safety and environmental applications. 展开更多
关键词 CO_(2)-induced coal strength meta-heuristic optimization algorithms XGBoost gene expression programming model interpretability
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Explicit modeling of mechanical property of hot-rolled strip steel based on data-driven and gene expression programming
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作者 Li Wang Qi-ning Zhu +2 位作者 Shun-hu Zhang Lei Zhang Jin-ping Zhang 《Journal of Iron and Steel Research International》 2025年第12期4281-4293,共13页
In order to solve the black-box modeling problem and improve the prediction accuracy of model,two distinguished models for tensile strength(Ts)and yield strength(Ys)of hot-rolled strip steel are established based on t... In order to solve the black-box modeling problem and improve the prediction accuracy of model,two distinguished models for tensile strength(Ts)and yield strength(Ys)of hot-rolled strip steel are established based on the industrial hot-rolled data and the algorithm of gene expression programming(GEP).Firstly,the industrial data of hot-rolled strip steel are preprocessed using the Pauta criterion,so as to eliminate outliers.The key input variables that affect Ys and Ts are selected by using the method of the maximal information coefficient(MIC).Secondly,the explicit prediction models of Ys and Ts are established using GEP.Subsequently,the model results based on GEP are compared with those based on the support vector regression(SVR)and the back propagation neural network(BPNN).Finally,the mathematical expression models for Ys and Ts obtained by GEP are used to further analyse the specific relationships between the chemical composition and mechanical property.It is shown that the errors of Ys and Ts based on GEP are less than 4%,and the coefficient of determination(R^(2))of Ys and Ts based on GEP is above 0.9,which has strong prediction performance.The prediction accuracy of GEP can achieve the same level with SVR and BPNN.It is worth mentioning that the proposed model can not only show the explicit relationship between the chemical composition,production process,and mechanical property of strip steel,but also occupy high prediction accuracy,which can make reliable reference for strip steel product design and optimisation. 展开更多
关键词 gene expression programming Hot-rolled steel Predication of mechanical property Back propagation neural network Support vector regression
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Evaluation of underground hard rock mine pillar stability using gene expression programming and decision tree-support vector machine models
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作者 Mohammad H.Kadkhodaei Ebrahim Ghasemi +1 位作者 Jian Zhou Melika Zahraei 《Deep Underground Science and Engineering》 2025年第1期18-34,共17页
Assessing the stability of pillars in underground mines(especially in deep underground mines)is a critical concern during both the design and the operational phases of a project.This study mainly focuses on developing... Assessing the stability of pillars in underground mines(especially in deep underground mines)is a critical concern during both the design and the operational phases of a project.This study mainly focuses on developing two practical models to predict pillar stability status.For this purpose,two robust models were developed using a database including 236 case histories from seven underground hard rock mines,based on gene expression programming(GEP)and decision tree-support vector machine(DT-SVM)hybrid algorithms.The performance of the developed models was evaluated based on four common statistical criteria(sensitivity,specificity,Matthews correlation coefficient,and accuracy),receiver operating characteristic(ROC)curve,and testing data sets.The results showed that the GEP and DT-SVM models performed exceptionally well in assessing pillar stability,showing a high level of accuracy.The DT-SVM model,in particular,outperformed the GEP model(accuracy of 0.914,sensitivity of 0.842,specificity of 0.929,Matthews correlation coefficient of 0.767,and area under the ROC of 0.897 for the test data set).Furthermore,upon comparing the developed models with the previous ones,it was revealed that both models can effectively determine the condition of pillar stability with low uncertainty and acceptable accuracy.This suggests that these models could serve as dependable tools for project managers,aiding in the evaluation of pillar stability during the design and operational phases of mining projects,despite the inherent challenges in this domain. 展开更多
关键词 decision tree-support vector machine(DT-SVM) gene expression programming(GEP) hard rock pillar stability underground mining
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A worldwide SPT-based soil liquefaction triggering analysis utilizing gene expression programming and Bayesian probabilistic method 被引量:3
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作者 Maral Goharzay Ali Noorzad +1 位作者 Ahmadreza Mahboubi Ardakani Mostafa Jalal 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2017年第4期683-693,共11页
In this context,two different approaches of soil liquefaction evaluation using a soft computing technique based on the worldwide standard penetration test(SPT) databases have been studied.Gene expression programming(G... In this context,two different approaches of soil liquefaction evaluation using a soft computing technique based on the worldwide standard penetration test(SPT) databases have been studied.Gene expression programming(GEP) as a gray-box modeling approach is used to develop different deterministic models in order to evaluate the occurrence of soil liquefaction in terms of liquefaction field performance indicator(LI) and factor of safety(FS) in logistic regression and classification concepts.The comparative plots illustrate that the classification concept-based models show a better performance than those based on logistic regression.In the probabilistic approach,a calibrated mapping function is developed in the context of Bayes’ theorem in order to capture the failure probabilities(PL) in the absence of the knowledge of parameter uncertainty.Consistent results obtained from the proposed probabilistic models,compared to the most well-known models,indicate the robustness of the methodology used in this study.The probability models provide a simple,but also efficient decision-making tool in engineering design to quantitatively assess the liquefaction triggering thresholds. 展开更多
关键词 LIQUEFACTION Soft computing technique gene expression programming(GEP) Deterministic model Bayes' theorem
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Scheduling Rules Based on Gene Expression Programming for Resource-Constrained Project Scheduling Problem 被引量:3
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作者 贾艳 李晋航 《Journal of Donghua University(English Edition)》 EI CAS 2015年第1期91-96,共6页
In order to minimize the project duration of resourceconstrained project scheduling problem( RCPSP), a gene expression programming-based scheduling rule( GEP-SR) method is proposed to automatically discover and select... In order to minimize the project duration of resourceconstrained project scheduling problem( RCPSP), a gene expression programming-based scheduling rule( GEP-SR) method is proposed to automatically discover and select the effective scheduling rules( SRs) which are constructed using the project status and attributes of the activities. SRs are represented by the chromosomes of GEP, and an improved parallel schedule generation scheme( IPSGS) is used to transform the SRs into explicit schedules. The framework of GEP-SR for RCPSP is designed,and the effectiveness of the GEP-SR approach is demonstrated by comparing with other methods on the same instances. 展开更多
关键词 resource-constrained project scheduling problem(RCPSP) gene expression programming(GEP) scheduling rules(SRs)
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Prediction of mode I fracture toughness of rock using linear multiple regression and gene expression programming 被引量:4
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作者 Bijan Afrasiabian Mosleh Eftekhari 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第5期1421-1432,共12页
Prediction of mode I fracture toughness(KIC) of rock is of significant importance in rock engineering analyses. In this study, linear multiple regression(LMR) and gene expression programming(GEP)methods were used to p... Prediction of mode I fracture toughness(KIC) of rock is of significant importance in rock engineering analyses. In this study, linear multiple regression(LMR) and gene expression programming(GEP)methods were used to provide a reliable relationship to determine mode I fracture toughness of rock. The presented model was developed based on 60 datasets taken from the previous literature. To predict fracture parameters, three mechanical parameters of rock mass including uniaxial compressive strength(UCS), Brazilian tensile strength(BTS), and elastic modulus(E) have been selected as the input parameters. A cluster of data was collected and divided into two random groups of training and testing datasets.Then, different statistical linear and artificial intelligence based nonlinear analyses were conducted on the training data to provide a reliable prediction model of KIC. These two predictive methods were then evaluated based on the testing data. To evaluate the efficiency of the proposed models for predicting the mode I fracture toughness of rock, various statistical indices including coefficient of determination(R2),root mean square error(RMSE), and mean absolute error(MAE) were utilized herein. In the case of testing datasets, the values of R2, RMSE, and MAE for the GEP model were 0.87, 0.188, and 0.156,respectively, while they were 0.74, 0.473, and 0.223, respectively, for the LMR model. The results indicated that the selected GEP model delivered superior performance with a higher R2value and lower errors. 展开更多
关键词 Mode I fracture Toughness Critical stress intensity factor Linear multiple regression(LMR) gene expression programming(GEP)
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A true triaxial strength criterion for rocks by gene expression programming 被引量:2
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作者 Jian Zhou Rui Zhang +1 位作者 Yingui Qiu Manoj Khandelwal 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第10期2508-2520,共13页
Rock strength is a crucial factor to consider when designing and constructing underground projects.This study utilizes a gene expression programming(GEP)algorithm-based model to predict the true triaxial strength of r... Rock strength is a crucial factor to consider when designing and constructing underground projects.This study utilizes a gene expression programming(GEP)algorithm-based model to predict the true triaxial strength of rocks,taking into account the influence of rock genesis on their mechanical behavior during the model building process.A true triaxial strength criterion based on the GEP model for igneous,metamorphic and magmatic rocks was obtained by training the model using collected data.Compared to the modified Weibols-Cook criterion,the modified Mohr-Coulomb criterion,and the modified Lade criterion,the strength criterion based on the GEP model exhibits superior prediction accuracy performance.The strength criterion based on the GEP model has better performance in R2,RMSE and MAPE for the data set used in this study.Furthermore,the strength criterion based on the GEP model shows greater stability in predicting the true triaxial strength of rocks across different types.Compared to the existing strength criterion based on the genetic programming(GP)model,the proposed criterion based on GEP model achieves more accurate predictions of the variation of true triaxial strength(s1)with intermediate principal stress(s2).Finally,based on the Sobol sensitivity analysis technique,the effects of the parameters of the three obtained strength criteria on the true triaxial strength of the rock are analysed.In general,the proposed strength criterion exhibits superior performance in terms of both accuracy and stability of prediction results. 展开更多
关键词 gene expression programming(GEP) True triaxial strength Rock failure criteria Intermediate principal stress
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Rules Mining-Based Gene Expression Programming for the Multi-Skill Resource Constrained Project Scheduling Problem 被引量:1
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作者 Min Hu Zhimin Chen +2 位作者 Yuan Xia Liping Zhang Qiuhua Tang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第9期2815-2840,共26页
Themulti-skill resource-constrained project scheduling problem(MS-RCPSP)is a significantmanagement science problem that extends from the resource-constrained project scheduling problem(RCPSP)and is integrated with a r... Themulti-skill resource-constrained project scheduling problem(MS-RCPSP)is a significantmanagement science problem that extends from the resource-constrained project scheduling problem(RCPSP)and is integrated with a real project and production environment.To solve MS-RCPSP,it is an efficient method to use dispatching rules combined with a parallel scheduling mechanism to generate a scheduling scheme.This paper proposes an improved gene expression programming(IGEP)approach to explore newly dispatching rules that can broadly solve MS-RCPSP.A new backward traversal decoding mechanism,and several neighborhood operators are applied in IGEP.The backward traversal decoding mechanism dramatically reduces the space complexity in the decoding process,and improves the algorithm’s performance.Several neighborhood operators improve the exploration of the potential search space.The experiment takes the intelligent multi-objective project scheduling environment(iMOPSE)benchmark dataset as the training set and testing set of IGEP.Ten newly dispatching rules are discovered and extracted by IGEP,and eight out of ten are superior to other typical dispatching rules. 展开更多
关键词 Project scheduling MULTI-SKILL gene expression programming dispatching rules
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Modeling viscosity of methane,nitrogen,and hydrocarbon gas mixtures at ultra-high pressures and temperatures using group method of data handling and gene expression programming techniques 被引量:1
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作者 Farzaneh Rezaei Saeed Jafari +1 位作者 Abdolhossein Hemmati-Sarapardeh Amir H.Mohammadi 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第4期431-445,共15页
Accurate gas viscosity determination is an important issue in the oil and gas industries.Experimental approaches for gas viscosity measurement are timeconsuming,expensive and hardly possible at high pressures and high... Accurate gas viscosity determination is an important issue in the oil and gas industries.Experimental approaches for gas viscosity measurement are timeconsuming,expensive and hardly possible at high pressures and high temperatures(HPHT).In this study,a number of correlations were developed to estimate gas viscosity by the use of group method of data handling(GMDH)type neural network and gene expression programming(GEP)techniques using a large data set containing more than 3000 experimental data points for methane,nitrogen,and hydrocarbon gas mixtures.It is worth mentioning that unlike many of viscosity correlations,the proposed ones in this study could compute gas viscosity at pressures ranging between 34 and 172 MPa and temperatures between 310 and 1300 K.Also,a comparison was performed between the results of these established models and the results of ten wellknown models reported in the literature.Average absolute relative errors of GMDH models were obtained 4.23%,0.64%,and 0.61%for hydrocarbon gas mixtures,methane,and nitrogen,respectively.In addition,graphical analyses indicate that the GMDH can predict gas viscosity with higher accuracy than GEP at HPHT conditions.Also,using leverage technique,valid,suspected and outlier data points were determined.Finally,trends of gas viscosity models at different conditions were evaluated. 展开更多
关键词 Gas Viscosity High pressure high temperature Group method of data handling gene expression programming
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Security Risk Assessment of Cyber Physical Power System Based on Rough Set and Gene Expression Programming 被引量:3
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作者 Song Deng Dong Yue +1 位作者 Xiong Fu Aihua Zhou 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI 2015年第4期431-439,共9页
Risk assessment is essential for the safe and reliable operation of cyber physical power system. Traditional security risk assessment methods do not take integration of cyber system and physical system of power grid i... Risk assessment is essential for the safe and reliable operation of cyber physical power system. Traditional security risk assessment methods do not take integration of cyber system and physical system of power grid into account. In order to solve this problem, security risk assessment algorithm of cyber physical power system based on rough set and gene expression programming is proposed. Firstly, fast attribution reduction based on binary search algorithm is presented. Secondly, security risk assessment function for cyber physical power system is mined based on gene expression programming. Lastly, security risk levels of cyber physical power system are predicted and analyzed by the above function model. Experimental results show that security risk assessment function model based on the proposed algorithm has high efficiency of function mining, accuracy of security risk level prediction and strong practicality. © 2014 Chinese Association of Automation. 展开更多
关键词 Algorithms Electric power system security gene expression geneS Rough set theory
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Hybrid Gene Expression Programming-Based Sensor Data Correlation Mining
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作者 Lechan Yang Zhihao Qin +1 位作者 Kun Wang Song Deng 《China Communications》 SCIE CSCD 2017年第1期34-49,共16页
This paper deals with the reflectance estimation model issue to improve the estimation accuracy. We propose a model containing two core procedures: dimensionality reduction and model mining. First, the dimensionality ... This paper deals with the reflectance estimation model issue to improve the estimation accuracy. We propose a model containing two core procedures: dimensionality reduction and model mining. First, the dimensionality reduction algorithm of hyperspectral data based on dependence degree(DRNDDD) is proposed to reduce the redundant hyperspectral band. DRND-DD solves the selection of suitable hyperspectral band via rough set theory. Furthermore, to improve the computation speed and accuracy of the model, based on DRND-DD, this paper proposes reflectance estimation model mining of leaf nitrogen concentration(LNC) for hyperspectral data by using hybrid gene expression programming(REMLNC-HGEP). Experimental results on three datasets demonstrate that the DRND-DD algorithm can obtain good results with a very short running time compared with principal component analysis(PCA), singular value decomposition(SVD), a dimensionality reduction algorithm based on the positive region(AR-PR) and a dimensionality reduction algorithm based on a discernable matrix(ARDM), and REMLNC-HGEP has low average time-consumption, high model mining success ratio and estimation accuracy. It was concluded that the REMLNC-HGEP performs better than the regression methods. 展开更多
关键词 reflectance estimation dimensionality reduction gene expression programming model mining
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An expert system for predicting shear stress distribution in circular open channels using gene expression programming 被引量:1
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作者 Zohreh Sheikh Khozani Hossein Bonakdari Isa Ebtehaj 《Water Science and Engineering》 EI CAS CSCD 2018年第2期167-176,共10页
The shear stress distribution in circular channels was modeled in this study using gene expression programming(GEP). 173 sets of reliable data were collected under four flow conditions for use in the training and test... The shear stress distribution in circular channels was modeled in this study using gene expression programming(GEP). 173 sets of reliable data were collected under four flow conditions for use in the training and testing stages. The effect of input variables on GEP modeling was studied and 15 different GEP models with individual, binary, ternary, and quaternary input combinations were investigated. The sensitivity analysis results demonstrate that dimensionless parameter y/P, where y is the transverse coordinate, and P is the wetted perimeter, is the most influential parameter with regard to the shear stress distribution in circular channels. GEP model 10, with the parameter y/P and Reynolds number(Re) as inputs, outperformed the other GEP models, with a coefficient of determination of 0.7814 for the testing data set. An equation was derived from the best GEP model and its results were compared with an artificial neural network(ANN) model and an equation based on the Shannon entropy proposed by other researchers. The GEP model, with an average RMSE of 0.0301, exhibits superior performance over the Shannon entropy-based equation, with an average RMSE of 0.1049, and the ANN model, with an average RMSE of 0.2815 for all flow depths. 展开更多
关键词 CIRCULAR channel gene expression programming(GEP) Sensitivity analysis SHEAR stress distribution SOFT computing
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Determining the Scour Dimensions Around Submerged Vanes in a 180°Bend with the Gene Expression Programming Technique 被引量:1
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作者 Saeid Shabanlou Hamed Azimi +1 位作者 Isa Ebtehaj Hossein Bonakdari 《Journal of Marine Science and Application》 CSCD 2018年第2期233-240,共8页
Submerged vanes are installed on rivers and channel beds to protect the outer bank bends from scouring.Also,local scouring occurs around the submerged vanes over time,and identifying the effective factors on the scour... Submerged vanes are installed on rivers and channel beds to protect the outer bank bends from scouring.Also,local scouring occurs around the submerged vanes over time,and identifying the effective factors on the scouring phenomena around these submerged vanes is one of the important issues in river engineering.The most important aimof this study is investigation of scour pattern around submerged vanes located in 180°bend experimentally and numerically.Firstly,the effects of various parameters such as the Froude number(Fr),angle of submerged vanes to the flow(α),angle of submerged vane location in the bend(θ),distance between submerged vanes(d),height(H),and length(L)of the vanes on the dimensionless volume of the scour hole were experimentally studied.The submerged vanes were installed on a 180°bend whose central radius and channel width were 2.8 and 0.6 m,respectively.By reducing the Froude number,the scour hole volume decreased.For all Froude numbers,the biggest scour hole formed atθ=15°.In all models,by increasing the Froude number,the scour hole volume significantly increases.In addition,by increasing the submerged vanes’length and height,the scour hole dimensions also grow.Secondly,using gene expression programming(GEP),a relationship for determining the scour hole volume around the submerged vanes was provided.For this model,the determination coefficients(R2)for the training and test modes were computed as 0.91 and 0.9,respectively.In addition,this study performed partial derivative sensitivity analysis(PDSA).According to the results,the PDSA was calculated as positive for all input variables. 展开更多
关键词 180°bend SUBMERGED vanes SCOUR HOLE volume gene expression programMING Partial DERIVATIVE sensitivity analysis
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Rapid Prototype Development Approach for Genetic Programming
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作者 Pei He Lei Zhang 《Journal of Computer and Communications》 2024年第2期67-79,共13页
Genetic Programming (GP) is an important approach to deal with complex problem analysis and modeling, and has been applied in a wide range of areas. The development of GP involves various aspects, including design of ... Genetic Programming (GP) is an important approach to deal with complex problem analysis and modeling, and has been applied in a wide range of areas. The development of GP involves various aspects, including design of genetic operators, evolutionary controls and implementations of heuristic strategy, evaluations and other mechanisms. When designing genetic operators, it is necessary to consider the possible limitations of encoding methods of individuals. And when selecting evolutionary control strategies, it is also necessary to balance search efficiency and diversity based on representation characteristics as well as the problem itself. More importantly, all of these matters, among others, have to be implemented through tedious coding work. Therefore, GP development is both complex and time-consuming. To overcome some of these difficulties that hinder the enhancement of GP development efficiency, we explore the feasibility of mutual assistance among GP variants, and then propose a rapid GP prototyping development method based on πGrammatical Evolution (πGE). It is demonstrated through regression analysis experiments that not only is this method beneficial for the GP developers to get rid of some tedious implementations, but also enables them to concentrate on the essence of the referred problem, such as individual representation, decoding means and evaluation. Additionally, it provides new insights into the roles of individual delineations in phenotypes and semantic research of individuals. 展开更多
关键词 genetic programming Grammatical Evolution gene Expression programming Regression Analysis Mathematical Modeling Rapid Prototype Development
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自噬相关基因在肺纤维化模型中的表达:生物信息学分析及实验验证
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作者 刘可新 郝凯敏 +1 位作者 庄文越 李正祎 《中国组织工程研究》 北大核心 2026年第5期1129-1138,共10页
背景:自噬对上皮细胞、成纤维细胞和肌成纤维细胞之间的应激作用与肺纤维化的形成过程密切相关。目的:筛选肺纤维化患者基因水平变化与自噬相关的基因,并探究其与肺纤维化患者预后的关联,以期为临床干预肺纤维化提供新的靶点。方法:以GS... 背景:自噬对上皮细胞、成纤维细胞和肌成纤维细胞之间的应激作用与肺纤维化的形成过程密切相关。目的:筛选肺纤维化患者基因水平变化与自噬相关的基因,并探究其与肺纤维化患者预后的关联,以期为临床干预肺纤维化提供新的靶点。方法:以GSE70866下载的基因表达谱数据集为训练集,利用R语言对肺纤维化患者和正常健康者之间基因表达进行差异分析并与自噬相关基因取交集,鉴定出变化最为显著的差异基因。运用多种分析方法筛选出关键预后基因,并构建基因预后模型。根据肺纤维化患者的风险评分分为高风险组和低风险组,应用Siena cohort和Leuven cohort验证集验证预后模型的有效性。并通过转化生长因子β1诱导HFL-1细胞(人胚肺成纤维细胞)建立肺纤维化细胞模型以及博莱霉素气管滴注建立小鼠肺纤维化动物模型验证预后基因的表达。结果与结论:①肺纤维化组织和正常组织之间存在2650个差异基因,其中与自噬相关基因有34个发生显著变化;②Siena cohort和Leuven cohort验证集的Kaplan-Meier生存分析曲线显示,高风险组的存活率明显比低风险组低;③筛选出3个与预后相关的自噬基因:骨髓瘤病病毒癌基因、趋化因子配体2、GABAA型受体相关蛋白样1;④体内外研究均显示与对照组相比,肺纤维化模型组骨髓瘤病病毒癌基因和趋化因子配体2 mRNA及蛋白表达显著升高(P<0.01,P<0.05),而GABAA型受体相关蛋白样1 mRNA及蛋白表达有所降低(P<0.001);⑤结论:通过生物信息学方法分析了3个自噬相关基因在肺纤维化中的表达及其与肺纤维化患者预后的相关性,构建的预后模型对肺纤维化患者1,2,3年生存率具有良好的预测能力;并且通过体内和体外模型验证了在肺纤维化细胞和组织中骨髓瘤病病毒癌基因和趋化因子配体2呈高水平表达,GABAA型受体相关蛋白样1呈低水平表达。 展开更多
关键词 肺纤维化 自噬 生物信息学 差异表达基因 预后模型 R语言 博莱霉素 TGF-β1
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Fetal and neonatal programming of postnatal growth and feed efficiency in swine 被引量:6
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作者 Yun Ji Zhenlong Wu +4 位作者 Zhaolai Dai Xiaolong Wang Ju Li Binggen Wang Guoyao Wu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2017年第4期764-778,共15页
Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects ... Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects may be carried over to the next generation or beyond. This phenomenon of the transgenerational impacts is known as fetal programming, which is mediated by stable and heritable alterations of gene expression through covalent modifications of DNA and histones without changes in DNA sequences(namely, epigenetics). The mechanisms responsible for the epigenetic regulation of protein expression and functions include chromatin remodeling; DNA methylation(occurring at the 5′-position of cytosine residues within CpG dinucleotides); and histone modifications(acetylation, methylation, phosphorylation, and ubiquitination). Like maternal malnutrition, undernutrition during the neonatal period also reduces growth performance and feed efficiency(weight gain:feed intake; also known as weightgain efficiency) in postweaning pigs by 5–10%, thereby increasing the days necessary to reach the market bodyweight. Supplementing functional amino acids(e.g., arginine and glutamine) and vitamins(e.g., folate) play a key role in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation. Therefore, these nutrients are beneficial for the dietary treatment of metabolic disorders in offspring with intrauterine growth restriction or neonatal malnutrition. The mechanism-based strategies hold great promise for the improvement of the efficiency of pork production and the sustainability of the global swine industry. 展开更多
关键词 EPIgeneTICS FETAL programMING gene expression NEONATAL programMING NUTRITION
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细胞程序性死亡配体1过表达增强人脐带间充质基质细胞的T细胞免疫抑制能力
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作者 梁紫涵 王蕊 +6 位作者 孙蕾 靳冉冉 吕朋举 李亚龙 程朝飞 岳寒 申思宁 《中国组织工程研究》 北大核心 2026年第19期4873-4881,共9页
背景:间充质基质细胞的T细胞免疫抑制作用为自身免疫性疾病的治疗带来新的希望,人脐带间充质基质细胞治疗药物艾米迈托赛注射液已被批准用于治疗14岁以上以消化道受累为主的激素治疗失败的急性移植物抗宿主病。因此,进一步探索间充质基... 背景:间充质基质细胞的T细胞免疫抑制作用为自身免疫性疾病的治疗带来新的希望,人脐带间充质基质细胞治疗药物艾米迈托赛注射液已被批准用于治疗14岁以上以消化道受累为主的激素治疗失败的急性移植物抗宿主病。因此,进一步探索间充质基质细胞的T细胞免疫抑制潜力能够为自身免疫性疾病治疗奠定基础。目的:细胞程序性死亡配体1基因过表达对人脐带间充质基质细胞抑制CD4+T细胞增殖的影响。方法:(1)人脐带间充质基质细胞体外培养至第0,1,2,3代,流式细胞仪检测细胞程序性死亡配体1阳性细胞比率;(2)将人脐带间充质基质细胞分为实验组和阴性对照组,实验组采用慢病毒介导细胞程序性死亡配体1基因修饰人脐带间充质基质细胞,阴性对照组为转染空白质粒载体慢病毒的人脐带间充质基质细胞,流式细胞术、实时荧光定量PCR和Western blot检测转染效率;(3)从健康人外周血中磁珠富集CD4+T细胞,经羧基荧光素二醋酸盐琥珀酰亚胺酯标记后以5∶1的比例与实验组和阴性对照组人脐带间充质基质细胞共培养,通过流式细胞术检测羧基荧光素二醋酸盐琥珀酰亚胺酯衰减的CD4+T细胞比例;(4)对实验组和阴性对照组人脐带间充质基质细胞进行RNA测序,同时对实验组人脐带间充质基质细胞进行单细胞RNA测序,并根据功能进行亚群分组,通过生物信息学分析方法描绘各个亚群标志基因热图、富集的信号通路和基因调控网络。结果与结论:(1)随着传代次数的增加,人脐带间充质基质细胞中细胞程序性死亡配体1阳性细胞百分比逐渐减少;(2)成功构建稳定过表达细胞程序性死亡配体1的人脐带间充质基质细胞,实验组细胞程序性死亡配体1的表达量显著增加;(3)转录组测序数据提示过表达细胞程序性死亡配体1的人脐带间充质基质细胞能够促进免疫效应调控通路相关基因表达上调;(4)通过将CD4+T细胞与人脐带间充质基质细胞共培养,结果显示实验组CD4+T细胞比例明显下调;(5)基于单细胞RNA测序结果,过表达细胞程序性死亡配体1的人脐带间充质基质细胞可分为3个功能亚群,具有异质性;细胞程序性死亡配体1基因水平在1亚群表达更高,且组蛋白甲基转移酶SETDB1显著高表达可能与T细胞免疫抑制功能增强密切相关。上述结果表明:细胞程序性死亡配体1基因过表达可以显著增强人脐带间充质基质细胞的T细胞免疫抑制能力。通过单细胞RNA测序可较好地根据细胞程序性死亡配体1基因修饰人脐带间充质基质细胞的功能特性进行分群,为提高人脐带间充质基质细胞的临床疗效提供理论支持。 展开更多
关键词 自身免疫性疾病 人脐带间充质基质细胞 细胞程序性死亡配体1 免疫抑制 免疫排斥 基因过表达 甲基转移酶 单细胞测序
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基于改进的多表达式编程算法的木材染色配方预测 被引量:2
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作者 管雪梅 张威 杨渠三 《科学技术与工程》 北大核心 2025年第7期2865-2873,共9页
由于珍贵木材日益稀缺以及过度开发导致的严重环境问题,有必要通过对普通木材进行染色来模仿珍贵木材的外观。在本研究中采用计算机辅助染色技术,实现对普通木材的高精度染色,从而创造出外观类似珍贵木材的替代品,减少人们对它们的依赖... 由于珍贵木材日益稀缺以及过度开发导致的严重环境问题,有必要通过对普通木材进行染色来模仿珍贵木材的外观。在本研究中采用计算机辅助染色技术,实现对普通木材的高精度染色,从而创造出外观类似珍贵木材的替代品,减少人们对它们的依赖。首先,基于基因表达编程(gene expression programming, GEP)的概念,提出了一种多表达式编程(multi-expression programming, MEP)算法来预测染料配比,考虑到多种染料之间的复杂相互作用,采用多基因表达,MEP算法能够处理这些复杂的多种染料之间的相互作用,从而得到更直观的函数表达式。为了提高MEP的函数挖掘准确性,自适应调整突变和重组算子的概率,并使用并行编程来增强函数挖掘效率。与基因表达编程的结果相比,MEP深入挖掘了函数关系,并在颜色预测中获得了0.113的相对偏差结果。 展开更多
关键词 木材染色 基因表达编程 多表达式编程 计算机颜色匹配 遗传算法 光谱反射率
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