Dear Editor,Due to the inaccessibility of early human embryos,little is known about the chromatin status during early human endothelial cell(EC)development.Despite studies showing the epigenomic landscape of primary E...Dear Editor,Due to the inaccessibility of early human embryos,little is known about the chromatin status during early human endothelial cell(EC)development.Despite studies showing the epigenomic landscape of primary EC lines or human pluripotent stem cell(hPSC)-derived ECs,the epigenetic dynamic and feature of intermediate progenitors,such as vascular mesoderm cells(VMCs)and endothelial progenitor cells(EPCs),are less known.Therefore,an epigenomic roadmap of human EC development may provide new knowledge about nascent EC formation.展开更多
基金the National Key R&D Program of China Grants 2022YFA1103103 and 2023YFA1800302the National Natural Science Foundation of China(NSFC)Grants 32270784 and 31970819 to J.N。
文摘Dear Editor,Due to the inaccessibility of early human embryos,little is known about the chromatin status during early human endothelial cell(EC)development.Despite studies showing the epigenomic landscape of primary EC lines or human pluripotent stem cell(hPSC)-derived ECs,the epigenetic dynamic and feature of intermediate progenitors,such as vascular mesoderm cells(VMCs)and endothelial progenitor cells(EPCs),are less known.Therefore,an epigenomic roadmap of human EC development may provide new knowledge about nascent EC formation.
