Gastritis cystica profunda(GCP)is a rare gastric disorder.It is characterized by non-specific symptoms and diagnostic complexity.This case report enriches the medical literature by highlighting challenges in diagnosin...Gastritis cystica profunda(GCP)is a rare gastric disorder.It is characterized by non-specific symptoms and diagnostic complexity.This case report enriches the medical literature by highlighting challenges in diagnosing and treating GCP.CASE SUMMARY Two patients presented with non-specific abdominal symptoms,such as abdominal distension and epigastric discomfort.Initial misdiagnosis occurred due to GCP’s non-typical manifestations.After thorough investigations,GCP was diagnosed.Endoscopic mucosal resection and endoscopic submucosal dissection were carried out.Both patients recovered uneventfully.CONCLUSION GCP diagnosis demands caution,and endoscopic treatment is effective.展开更多
Gastric cystica profunda(GCP)is an uncommon but underestimated gastric lesion.Its precancerous potential determines its significance.In addition to previous mucosa injury due to operations,biopsy or polypectomy,chroni...Gastric cystica profunda(GCP)is an uncommon but underestimated gastric lesion.Its precancerous potential determines its significance.In addition to previous mucosa injury due to operations,biopsy or polypectomy,chronic active and atrophic gastritis may also lead to the development of GCPs.By carefully examining the stomach and taking biopsy samples from the susceptible regions,the stage of atrophy can be determined.Chronic atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to GCPs formation.GCPs frequently occur close to early gastric cancers(EGCs)or EGC can arise from the cystic glands.Endoscopic resection is an effective and minimally invasive treat-ment in GCP.展开更多
BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal layers.GCP is often linked to,or may progress into,early gast...BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal layers.GCP is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and treatment.METHODS This retrospective study involved 104 patients with GCP who underwent endoscopic resection.Alongside demographic and clinical data,regular patient followups were conducted to assess local recurrence.RESULTS Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric procedures.The primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with EGC.Univariate analysis indicated that elderly males were more susceptible to GCP associated with EGC.Conversely,multivariate analysis identified lesion morphology and endoscopic features as significant risk factors.Survival analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.展开更多
Gastric cancer presents a significant global health burden,as it is the fifth most common malignancy and fourth leading cause of cancer mortality worldwide.Variations in incidence rates across regions underscores the ...Gastric cancer presents a significant global health burden,as it is the fifth most common malignancy and fourth leading cause of cancer mortality worldwide.Variations in incidence rates across regions underscores the multifactorial etiology of this disease.The overall 5-year survival rate remains low despite advances in its diagnosis and treatment.Although surgical gastrectomy was previously standard-of-care,endoscopic resection techniques,including endoscopic mucosal resection and endoscopic submucosal dissection(ESD)have emerged as effective alternatives for early lesions.Compared to surgical resection,endoscopic resection techniques have comparable 5-year survival rates,reduced treatment-related adverse events,shorter hospital stays and lower costs.ESD also enables en bloc resection,thus affording organ-sparing curative endoscopic resection for early cancers.In this editorial,we comment on the recent publication by Geng et al regarding gastric cystica profunda(GCP).GCP is a rare gastric pseudotumour with the potential for malignant progression.GCP presents a diagnostic challenge due to its nonspecific clinical manifestations and varied endoscopic appearance.There are several gaps in the literature regarding the diagnosis and management of GCP which warrants further research to standardize patient management.Advances in endoscopic resection techniques offer promising avenues for GCP and early gastric cancers.展开更多
Gastritis cystica profunda is a relatively rare disease, usually observed at anastomotic sites in stomachs of patients that have undergone gastric procedures. We present the rare case of an elevated lesion in the ante...Gastritis cystica profunda is a relatively rare disease, usually observed at anastomotic sites in stomachs of patients that have undergone gastric procedures. We present the rare case of an elevated lesion in the anterior wall of the gastric antrum of a 43-year-old Chinese woman who had never undergone gastric surgery and had no gastrointestinal tract symptoms. Although the physical examination and laboratory data showed no abnormalities, endoscopic ultrasonography revealed an anechoic cystic structure. Abdominalcomputed tomography and magnetic resonance imaging showed the gastric wall of the greater curvature of the antrum was markedly and irregularly thickened, and mild to moderate enhancement was observed around the lesion with no enhancement in the central portion, suggestive of a gastrointestinal stromal tumor. The patient underwent a distal gastric resection of the 2.5 cm × 1.5 cm lesion. A postoperative pathologic examination showed dilated cystic glands in the muscularis mucosa and submucosal layers and erosion of the mucosal surface of the tumor, confirming the diagnosis of gastritis cystica profunda without malignancy.展开更多
Gastritis cystica profunda(GCP) is a rare condition caused by ectopic entrapment of gastric glands,probably secondary to the disruption of muscularis mucosae.GCP is often associated with gastric adenocarcinoma,and los...Gastritis cystica profunda(GCP) is a rare condition caused by ectopic entrapment of gastric glands,probably secondary to the disruption of muscularis mucosae.GCP is often associated with gastric adenocarcinoma,and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy.In this study,we,for the first time,analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation.展开更多
Colitis cystic profunda is a rare entity benign condition of the colon and rectum that can mimic suspicious polyps or malignancy. The commonest sites of affectation are the rectum and the sigmoid colon but it can be u...Colitis cystic profunda is a rare entity benign condition of the colon and rectum that can mimic suspicious polyps or malignancy. The commonest sites of affectation are the rectum and the sigmoid colon but it can be unusually widely distributed in the colon. The aetiology of this condition is not fully elucidated and confident diagnosis can only be made on histological features. We hereby describe a patient who presented with significant rectal symptoms and an unexpected finding of a submucosal mucous cyst mimicking a suspicious rectal polyp and highlighted its significance and the review of the literature.展开更多
Profunda femoris vein (PFV) rarely forms a direct communication with the lower end of the femoral vein (FV) or popliteal vein (PV). During regular dissections for medical undergraduates, we came across a rare anatomic...Profunda femoris vein (PFV) rarely forms a direct communication with the lower end of the femoral vein (FV) or popliteal vein (PV). During regular dissections for medical undergraduates, we came across a rare anatomical variation of PFV in the right lower limb of an 80-year-old female cadaver. PFV commenced from the PV just above its formation by the union of anterior and posterior tibial veins. It traversed the popliteal fossa on the lateral side of the popliteal artery and entered into the adductor canal after piercing the adductor magnus muscle. Finally, it emptied into the FV in the lower part of the femoral triangle. Furthermore, the PV had a small caliber than that of PFV. Deep veins of leg are the common site for formation of thrombosis. In terms of diagnosis and operative procedures, the location of thrombosis in the deep veins of lower limb is clinically of great importance. Thus detailed knowledge of the anatomical variation reported here is useful during diagnosis and treatment of deep vein thrombosis.展开更多
The gold standard for post-mastectomy autologous breast reconstruction is abdominally based free flaps.For patients with contraindications to abdominal free flap reconstruction,utilization of other donor sites should ...The gold standard for post-mastectomy autologous breast reconstruction is abdominally based free flaps.For patients with contraindications to abdominal free flap reconstruction,utilization of other donor sites should be considered.The profunda artery perforator flap has become a popular option for autologous reconstruction as it offers many advantages,including a long pedicle,muscle preservation,and easy soft tissue contouring.This review will provide an extensive outline of the history,anatomy,clinical indications,surgical techniques,and outcomes of the profunda artery perforator flap.It will also discuss appropriate preoperative imaging(CTA,MRA)and present a case of a patient who received a profunda artery perforator flap at our institution.展开更多
Colitis cystica profunda （CCP） is a benign disease characterized by mucin-filled cysts beneath the muscularis mucosa.（II CCP can present in a localized form with a polypoid lesion, or as a more diffuse process invo...Colitis cystica profunda （CCP） is a benign disease characterized by mucin-filled cysts beneath the muscularis mucosa.（II CCP can present in a localized form with a polypoid lesion, or as a more diffuse process involving a variable length of the rectal mucosa or colon. Cysts, which may be quite large, are localized to the rectosigmoid region and are usually 6 to 7 cm from the anal verge. CCP has been observed in patients between 30 and 40 years of age.展开更多
文摘Gastritis cystica profunda(GCP)is a rare gastric disorder.It is characterized by non-specific symptoms and diagnostic complexity.This case report enriches the medical literature by highlighting challenges in diagnosing and treating GCP.CASE SUMMARY Two patients presented with non-specific abdominal symptoms,such as abdominal distension and epigastric discomfort.Initial misdiagnosis occurred due to GCP’s non-typical manifestations.After thorough investigations,GCP was diagnosed.Endoscopic mucosal resection and endoscopic submucosal dissection were carried out.Both patients recovered uneventfully.CONCLUSION GCP diagnosis demands caution,and endoscopic treatment is effective.
文摘Gastric cystica profunda(GCP)is an uncommon but underestimated gastric lesion.Its precancerous potential determines its significance.In addition to previous mucosa injury due to operations,biopsy or polypectomy,chronic active and atrophic gastritis may also lead to the development of GCPs.By carefully examining the stomach and taking biopsy samples from the susceptible regions,the stage of atrophy can be determined.Chronic atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to GCPs formation.GCPs frequently occur close to early gastric cancers(EGCs)or EGC can arise from the cystic glands.Endoscopic resection is an effective and minimally invasive treat-ment in GCP.
基金Supported by the 74th General Support of China Postdoctoral Science Foundation,No.2023M740675the National Natural Science Foundation of China,No.82170555+2 种基金Shanghai Academic/Technology Research Leader,No.22XD1422400Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission,No.2022SG06Shanghai"Rising Stars of Medical Talent"Youth Development Program,No.20224Z0005.
文摘BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal layers.GCP is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and treatment.METHODS This retrospective study involved 104 patients with GCP who underwent endoscopic resection.Alongside demographic and clinical data,regular patient followups were conducted to assess local recurrence.RESULTS Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric procedures.The primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with EGC.Univariate analysis indicated that elderly males were more susceptible to GCP associated with EGC.Conversely,multivariate analysis identified lesion morphology and endoscopic features as significant risk factors.Survival analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.
文摘Gastric cancer presents a significant global health burden,as it is the fifth most common malignancy and fourth leading cause of cancer mortality worldwide.Variations in incidence rates across regions underscores the multifactorial etiology of this disease.The overall 5-year survival rate remains low despite advances in its diagnosis and treatment.Although surgical gastrectomy was previously standard-of-care,endoscopic resection techniques,including endoscopic mucosal resection and endoscopic submucosal dissection(ESD)have emerged as effective alternatives for early lesions.Compared to surgical resection,endoscopic resection techniques have comparable 5-year survival rates,reduced treatment-related adverse events,shorter hospital stays and lower costs.ESD also enables en bloc resection,thus affording organ-sparing curative endoscopic resection for early cancers.In this editorial,we comment on the recent publication by Geng et al regarding gastric cystica profunda(GCP).GCP is a rare gastric pseudotumour with the potential for malignant progression.GCP presents a diagnostic challenge due to its nonspecific clinical manifestations and varied endoscopic appearance.There are several gaps in the literature regarding the diagnosis and management of GCP which warrants further research to standardize patient management.Advances in endoscopic resection techniques offer promising avenues for GCP and early gastric cancers.
文摘Gastritis cystica profunda is a relatively rare disease, usually observed at anastomotic sites in stomachs of patients that have undergone gastric procedures. We present the rare case of an elevated lesion in the anterior wall of the gastric antrum of a 43-year-old Chinese woman who had never undergone gastric surgery and had no gastrointestinal tract symptoms. Although the physical examination and laboratory data showed no abnormalities, endoscopic ultrasonography revealed an anechoic cystic structure. Abdominalcomputed tomography and magnetic resonance imaging showed the gastric wall of the greater curvature of the antrum was markedly and irregularly thickened, and mild to moderate enhancement was observed around the lesion with no enhancement in the central portion, suggestive of a gastrointestinal stromal tumor. The patient underwent a distal gastric resection of the 2.5 cm × 1.5 cm lesion. A postoperative pathologic examination showed dilated cystic glands in the muscularis mucosa and submucosal layers and erosion of the mucosal surface of the tumor, confirming the diagnosis of gastritis cystica profunda without malignancy.
基金Supported by The Grant-in-Aid from Ministry of Education, Culture,Sports,Science and Technology,Japan
文摘Gastritis cystica profunda(GCP) is a rare condition caused by ectopic entrapment of gastric glands,probably secondary to the disruption of muscularis mucosae.GCP is often associated with gastric adenocarcinoma,and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy.In this study,we,for the first time,analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation.
文摘Colitis cystic profunda is a rare entity benign condition of the colon and rectum that can mimic suspicious polyps or malignancy. The commonest sites of affectation are the rectum and the sigmoid colon but it can be unusually widely distributed in the colon. The aetiology of this condition is not fully elucidated and confident diagnosis can only be made on histological features. We hereby describe a patient who presented with significant rectal symptoms and an unexpected finding of a submucosal mucous cyst mimicking a suspicious rectal polyp and highlighted its significance and the review of the literature.
文摘Profunda femoris vein (PFV) rarely forms a direct communication with the lower end of the femoral vein (FV) or popliteal vein (PV). During regular dissections for medical undergraduates, we came across a rare anatomical variation of PFV in the right lower limb of an 80-year-old female cadaver. PFV commenced from the PV just above its formation by the union of anterior and posterior tibial veins. It traversed the popliteal fossa on the lateral side of the popliteal artery and entered into the adductor canal after piercing the adductor magnus muscle. Finally, it emptied into the FV in the lower part of the femoral triangle. Furthermore, the PV had a small caliber than that of PFV. Deep veins of leg are the common site for formation of thrombosis. In terms of diagnosis and operative procedures, the location of thrombosis in the deep veins of lower limb is clinically of great importance. Thus detailed knowledge of the anatomical variation reported here is useful during diagnosis and treatment of deep vein thrombosis.
基金supported in part by the Cancer Center Support Grant P30 CA008748,which supports the research infrastructure at Memorial Sloan Kettering Cancer Center.
文摘The gold standard for post-mastectomy autologous breast reconstruction is abdominally based free flaps.For patients with contraindications to abdominal free flap reconstruction,utilization of other donor sites should be considered.The profunda artery perforator flap has become a popular option for autologous reconstruction as it offers many advantages,including a long pedicle,muscle preservation,and easy soft tissue contouring.This review will provide an extensive outline of the history,anatomy,clinical indications,surgical techniques,and outcomes of the profunda artery perforator flap.It will also discuss appropriate preoperative imaging(CTA,MRA)and present a case of a patient who received a profunda artery perforator flap at our institution.
文摘Colitis cystica profunda （CCP） is a benign disease characterized by mucin-filled cysts beneath the muscularis mucosa.（II CCP can present in a localized form with a polypoid lesion, or as a more diffuse process involving a variable length of the rectal mucosa or colon. Cysts, which may be quite large, are localized to the rectosigmoid region and are usually 6 to 7 cm from the anal verge. CCP has been observed in patients between 30 and 40 years of age.
