Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia ind...Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 75.23±21.46 U/L; Cr 82.69±18.41μmol/L; LDH 944.67±834.32 U/L; TnT 0.336±0.076 ng/ml).Conclusion: Profound hypothermia-induced SADR is an effective method for inducing cardiac arrest. Our results indicate that inducing CA for 90 min(at 15℃) is safer than doing so for 120 min. Our results indicate that 120 min of CA at 15℃ is dangerous and can result in high mortality and severe neurological complications. Further experimentation is needed to determine whether 120 min of CA at temperatures lower than 15℃ can lead to safe recovery.展开更多
Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous ...Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous membranous structure and similar receptor cell ultrastructures, the cochlea and vestibule may be susceptible to the same harmful factors. Disorders of the inner ear may result in a variety of manifestations, including vertigo, spatial disorientation, blurred vision, impaired articulation, and hearing impairment. Considering the diversity of clinical symptoms associated with PSHL with otolithic dysfunction, it may be frequently misdiagnosed, and objective means of testing the function of otolithic organs should be recommended for hearing-impaired patients. Vestibular-evoked myogenic potentials (VEMPs) via air-conducted sound are of great importance for the diagnosis of otolithic function. Hearing devices such as cochlear implants are commonly accepted treatments for PSHL, and early identification and treatment of vestibular disorders may increase the success rate of cochlear implantation. Therefore, it is necessary to increase awareness of otolithic functional states in patients with PSHL.展开更多
In this short review paper, the significant and profound impacts of the Chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.
In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="...In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="EN-US" style="line-height: 97%;font-family:;" capt",serif;font-size:11pt;"="" pro="" minion="">been briefly recalled with crystal clear convincingness.</span></span></span>展开更多
In this short review paper, the significant and profound impacts of the Pseudo Amino Acid Composition or PseAAC have been briefly presented with crystal clear convincingness.
Aremarkable feature of the profound changes unseen in centuries is the major shift in the international balance of power,with one of the most important changes being the rise of the Global South.The Global South is no...Aremarkable feature of the profound changes unseen in centuries is the major shift in the international balance of power,with one of the most important changes being the rise of the Global South.The Global South is not a small bloc but a group of nations that refers to the vast majority of developing countries.Aggregating and designating these developing countries as a group and as the Global South carries significant special meaning.Although countries of the Global South differ significantly in their domestic political systems,economic development level,foreign relations,and social and cultural lives,they share a consensus on many major issues,particularly in the domain of autonomous development,promoting cooperation,maintaining open world order,and advocating for a more equitable and reasonable international order.展开更多
Fifty-three patients with congenital heart disease were follwed up 14 to 57months after cardiac surgery with profound hypothermia and circulatory arrest.Meanintelligence quotient(IQ)was 88.6±16.1The incidence of ...Fifty-three patients with congenital heart disease were follwed up 14 to 57months after cardiac surgery with profound hypothermia and circulatory arrest.Meanintelligence quotient(IQ)was 88.6±16.1The incidence of psychological underdevelopedwas 13.2(7/53),higher than normal children population,The high incidence may be attri-buted to poor preoperative intellecutual development.The circulatory arrest time weremore than 60 minutes in 9 cases,41-60 minutes in 32 cases and less than 40 minutes inanother 12 cases.The IQ of these three groups were 84.8±11.9,86.2±15.7and 95.3±19.2respctively and incidence of psychological underdeveloped were 11.1%,15.6% and 8.5%respectively,No significant difference existed between groups.The time of circulatory ar-rest also had no obvious correlation with IQ.展开更多
The world today is undergoing profound changes unseen in a century.In particular,under the impact of the COVID-19 pandemic and the Ukraine crisis,the global political and economic landscape has undergone unprecedented...The world today is undergoing profound changes unseen in a century.In particular,under the impact of the COVID-19 pandemic and the Ukraine crisis,the global political and economic landscape has undergone unprecedentedly profound changes,and the current global economic governance system is facing multiple crises,such as the lack of legitimacy,effectiveness,and common values.Hence,promoting the reform of the global governance system is becoming the prevailing trend.展开更多
The 17th century Holland still life drawing mostly all is through the extremely rigorous science manner, concentrates on completely to carry on the description to some lifeless goods. Such as flowers, shells, fruit an...The 17th century Holland still life drawing mostly all is through the extremely rigorous science manner, concentrates on completely to carry on the description to some lifeless goods. Such as flowers, shells, fruit and other things and of this style is the product of the Dutch culture, which represented by observing depict static objects, record the many realistic scene of eternal charm. Precise visual science and prosperity in the Netherlands, some of the new invention made evidence for its science and technology, such as microscope and camera, like the golden age of fine painting. It has some aspect research also to take compared to the vision, for example the botany, explains the showing plant flowers and plants with the science method in the different growh stage significance. In the philosophy domain, in the visual optics and under the technical development, the epistemology obtained the further development. The Dutch painters also recorded the world in a more detailed and vivid way through their methods.展开更多
To investigate the effects of different degrees of hemodilution on neurological injury and amino acid content in different brain areas after deep hypothermic circulatory arrest (DHCA).Methods Forty-eight male adult SD...To investigate the effects of different degrees of hemodilution on neurological injury and amino acid content in different brain areas after deep hypothermic circulatory arrest (DHCA).Methods Forty-eight male adult SD rats weighing 400～450 g were randomly divided into 4 groups (n=12 each):group Ⅰ Hct 10%(H1);group Ⅱ Hct 20% (H2);group Ⅲ Hct 30%(H3) and control group (C).All animals except those in control group underwent DHCA at 18℃ for 90 min (includinhg cooling and rewarming) under general anesthesia with fentanyl,ketamine and droperidol.Different degrees of hemodilution were accomplised by changing the composition and volume of priming solution used in cardiopulmonary bypass (CPB).Hct was determined before,at the initiation of CPB and beginning of rewarming.PaO2,pH and blood lactate of arterial blood and SO2 of venous blood from internal jugular vein (SjvO2) were determined at the beginning and end of cooling and rewarming.The animals were killed and brains removed after recovery of circulatory function for the count of injured neurons and detemination of glutamate (Glu),aspartate (Asp),glycine (Gly),γ-aminobutyric acid (GABA) and taurine (Tau) contents in cortex,hippocampus and thalamus.Results The number of injured neurons in hippocampus and parietal cortex were significantly smaller in Hct 30% group than in the other two groups (P<0.05).The contents of the five amino acids in hippocampus and parietal cortex were all increased after DHCA.The Glu,Asp and Gly contents in hippocampus and parietal cortex were significantly lower in Hct 30% group than in the other 2 groups (P<0.05).There was no significant difference in GABA and Tau contents among the 3 groups.Conclusion Hemodilution at Hct 30% attenuates the neuronal injury after DHCA.The inhibition of the release of the excitatory amino acids in the brain may be involved in the mechanism of neuronal protection.13 refs,1 fig,3 tabs.展开更多
To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situ...To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situation and international situation,and is an important part of the CPCCC‘s展开更多
The world is undergoing"profound changes unseen in a century",which is crucial for current development of international taxation.The trends of"world multi-polarization,economic globalization,IT applicat...The world is undergoing"profound changes unseen in a century",which is crucial for current development of international taxation.The trends of"world multi-polarization,economic globalization,IT application and cultural diversity"are surging forward.New driving forces are replacing the old ones.Balance among different countries is also changing rapidly.A global governance system is thus reshaping.Based on all these changes,this paper analyzes their impacts on international taxation,and particularly the Belt and Road Initiative Tax Administration Cooperation Mechanism(BRITACOM).展开更多
基金supported by the Major Project for Equipment Development of PLA in 2013(ASY135001)the National High Technology Research and Development Program of China(2015AA020312)
文摘Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 75.23±21.46 U/L; Cr 82.69±18.41μmol/L; LDH 944.67±834.32 U/L; TnT 0.336±0.076 ng/ml).Conclusion: Profound hypothermia-induced SADR is an effective method for inducing cardiac arrest. Our results indicate that inducing CA for 90 min(at 15℃) is safer than doing so for 120 min. Our results indicate that 120 min of CA at 15℃ is dangerous and can result in high mortality and severe neurological complications. Further experimentation is needed to determine whether 120 min of CA at temperatures lower than 15℃ can lead to safe recovery.
文摘Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous membranous structure and similar receptor cell ultrastructures, the cochlea and vestibule may be susceptible to the same harmful factors. Disorders of the inner ear may result in a variety of manifestations, including vertigo, spatial disorientation, blurred vision, impaired articulation, and hearing impairment. Considering the diversity of clinical symptoms associated with PSHL with otolithic dysfunction, it may be frequently misdiagnosed, and objective means of testing the function of otolithic organs should be recommended for hearing-impaired patients. Vestibular-evoked myogenic potentials (VEMPs) via air-conducted sound are of great importance for the diagnosis of otolithic function. Hearing devices such as cochlear implants are commonly accepted treatments for PSHL, and early identification and treatment of vestibular disorders may increase the success rate of cochlear implantation. Therefore, it is necessary to increase awareness of otolithic functional states in patients with PSHL.
文摘In this short review paper, the significant and profound impacts of the Chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.
文摘In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="EN-US" style="line-height: 97%;font-family:;" capt",serif;font-size:11pt;"="" pro="" minion="">been briefly recalled with crystal clear convincingness.</span></span></span>
文摘In this short review paper, the significant and profound impacts of the Pseudo Amino Acid Composition or PseAAC have been briefly presented with crystal clear convincingness.
文摘Aremarkable feature of the profound changes unseen in centuries is the major shift in the international balance of power,with one of the most important changes being the rise of the Global South.The Global South is not a small bloc but a group of nations that refers to the vast majority of developing countries.Aggregating and designating these developing countries as a group and as the Global South carries significant special meaning.Although countries of the Global South differ significantly in their domestic political systems,economic development level,foreign relations,and social and cultural lives,they share a consensus on many major issues,particularly in the domain of autonomous development,promoting cooperation,maintaining open world order,and advocating for a more equitable and reasonable international order.
文摘Fifty-three patients with congenital heart disease were follwed up 14 to 57months after cardiac surgery with profound hypothermia and circulatory arrest.Meanintelligence quotient(IQ)was 88.6±16.1The incidence of psychological underdevelopedwas 13.2(7/53),higher than normal children population,The high incidence may be attri-buted to poor preoperative intellecutual development.The circulatory arrest time weremore than 60 minutes in 9 cases,41-60 minutes in 32 cases and less than 40 minutes inanother 12 cases.The IQ of these three groups were 84.8±11.9,86.2±15.7and 95.3±19.2respctively and incidence of psychological underdeveloped were 11.1%,15.6% and 8.5%respectively,No significant difference existed between groups.The time of circulatory ar-rest also had no obvious correlation with IQ.
文摘The world today is undergoing profound changes unseen in a century.In particular,under the impact of the COVID-19 pandemic and the Ukraine crisis,the global political and economic landscape has undergone unprecedentedly profound changes,and the current global economic governance system is facing multiple crises,such as the lack of legitimacy,effectiveness,and common values.Hence,promoting the reform of the global governance system is becoming the prevailing trend.
文摘The 17th century Holland still life drawing mostly all is through the extremely rigorous science manner, concentrates on completely to carry on the description to some lifeless goods. Such as flowers, shells, fruit and other things and of this style is the product of the Dutch culture, which represented by observing depict static objects, record the many realistic scene of eternal charm. Precise visual science and prosperity in the Netherlands, some of the new invention made evidence for its science and technology, such as microscope and camera, like the golden age of fine painting. It has some aspect research also to take compared to the vision, for example the botany, explains the showing plant flowers and plants with the science method in the different growh stage significance. In the philosophy domain, in the visual optics and under the technical development, the epistemology obtained the further development. The Dutch painters also recorded the world in a more detailed and vivid way through their methods.
文摘To investigate the effects of different degrees of hemodilution on neurological injury and amino acid content in different brain areas after deep hypothermic circulatory arrest (DHCA).Methods Forty-eight male adult SD rats weighing 400～450 g were randomly divided into 4 groups (n=12 each):group Ⅰ Hct 10%(H1);group Ⅱ Hct 20% (H2);group Ⅲ Hct 30%(H3) and control group (C).All animals except those in control group underwent DHCA at 18℃ for 90 min (includinhg cooling and rewarming) under general anesthesia with fentanyl,ketamine and droperidol.Different degrees of hemodilution were accomplised by changing the composition and volume of priming solution used in cardiopulmonary bypass (CPB).Hct was determined before,at the initiation of CPB and beginning of rewarming.PaO2,pH and blood lactate of arterial blood and SO2 of venous blood from internal jugular vein (SjvO2) were determined at the beginning and end of cooling and rewarming.The animals were killed and brains removed after recovery of circulatory function for the count of injured neurons and detemination of glutamate (Glu),aspartate (Asp),glycine (Gly),γ-aminobutyric acid (GABA) and taurine (Tau) contents in cortex,hippocampus and thalamus.Results The number of injured neurons in hippocampus and parietal cortex were significantly smaller in Hct 30% group than in the other two groups (P<0.05).The contents of the five amino acids in hippocampus and parietal cortex were all increased after DHCA.The Glu,Asp and Gly contents in hippocampus and parietal cortex were significantly lower in Hct 30% group than in the other 2 groups (P<0.05).There was no significant difference in GABA and Tau contents among the 3 groups.Conclusion Hemodilution at Hct 30% attenuates the neuronal injury after DHCA.The inhibition of the release of the excitatory amino acids in the brain may be involved in the mechanism of neuronal protection.13 refs,1 fig,3 tabs.
文摘To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situation and international situation,and is an important part of the CPCCC‘s
文摘The world is undergoing"profound changes unseen in a century",which is crucial for current development of international taxation.The trends of"world multi-polarization,economic globalization,IT application and cultural diversity"are surging forward.New driving forces are replacing the old ones.Balance among different countries is also changing rapidly.A global governance system is thus reshaping.Based on all these changes,this paper analyzes their impacts on international taxation,and particularly the Belt and Road Initiative Tax Administration Cooperation Mechanism(BRITACOM).
