A multi-point flexible straightening process characterized by reciprocating bending is proposed.Specifically,the process is analyzed in terms of deformation mechanism and verified by numerical simulations and physical...A multi-point flexible straightening process characterized by reciprocating bending is proposed.Specifically,the process is analyzed in terms of deformation mechanism and verified by numerical simulations and physical experiments of the straightening of a series of metal profiles with different materials and initial shapes.Further,the relationship between the bending radius and the times of reciprocating bending required to unify the curvature is discussed,and the distribution of residual stress after straightening is analyzed.The results show that the reciprocating bending process can eliminate the difference of the initial curvature,make the curvature of each section tend to be uniform;the times of reciprocating bending to reach the uniform curvature decreases with the decrease of bending radius.The straightness of the straightened profile obtained from the experiment and simulation is less than 0.2%,demonstrating a good feasibility of this method.展开更多
In this paper, some distinctive features of the vertical profile of precipitable liquid water content (LWC) with considerable respect to rain rates (R) and radar reflectivity (Z) obtained in a tropical location are pr...In this paper, some distinctive features of the vertical profile of precipitable liquid water content (LWC) with considerable respect to rain rates (R) and radar reflectivity (Z) obtained in a tropical location are presented. Assessment of LWC allows applications in the specific area of flight icing severity, aviation safety as well as signals traversing through the atmosphere. The parameters were typically measured using vertically-pointing Micro Rain Radar (MRR) over a period of 2 years (2011-2012) at Akure, a tropical location of Nigeria. The radar scanned at every 10 seconds and integrated over one minute samples to reduce event logging error associated with the instrument. The vertical profile of the LWC typically reveals a prominent seasonal variation. However, majority of the LWC profiles has low LWC, less than 0.1 gm?3 while the maximum observed LWC is about 3.18 gm?3. A strong like hood relation was observed between the melting layer height and the LWC, with the LWC reaches peak at the considerable height of about 4160 m which coincides precisely with the freezing height level (rain height of ~4520 m) of the study location. Good correlation was also observed between the LWC and R in most of the heights considered. The results obtained will assist system engineers to assess the level of absorption, reflection and attenuation of electromagnetic signals as a result of precipitable LWC along the transmitting paths. The novelty of the present work is in the area of linking LWC and Z as against usual relation between Z and R.展开更多
The 89 and 150 GHz channels operated in window are sensitive to precipitation and humidity. The 183 GHz humidity-sensitive channels and 118 GHz temperature-sensitive channels of the Microwave Humidity and Temperature ...The 89 and 150 GHz channels operated in window are sensitive to precipitation and humidity. The 183 GHz humidity-sensitive channels and 118 GHz temperature-sensitive channels of the Microwave Humidity and Temperature Sounder (MWHTS) on the Chinese Feng Yun 3C MWHTS (FY-3C MWHTS) polar-orbit meteorological satellite responds in part to precipitation. Combining 118 and 183 GHz channels, the paper develops a passive sub-millimeter atmospheric profile and precipitation retrievals algorithm for MWHTS onboard the FY-3C (Feng Yun-3C) satellite. The retrieval algorithm employs a number of back propagation neural network estimators trained and evaluated using the validated global reference physical model NCEP/WRF/ARTS and works for land and seawater with latitude between -40 to 40 degree. NCEP data per 6 hours were downloaded to run the Weather Research and Forecast model WRF, and to derive the typical precipitation data for the whole world. The Atmospheric Radiative Transfer Simulator ARTS is feasible for performing simulations of atmospheric radiative transfer. The results show that the profile retrievals using BP-NN algorithm has the best correlation with those from radiosonde, which is less than 18% and 1 K of root mean square error, respectively. For precipitation rate retrievals, a much better agreement is reached with rain gauge and ECMWF datasets, the RMS is between 0.80 to 30.24 mm/h for sea surface and 0.789 to 33.11 mm/h for land surface according to the classification by precipitation type. Also, the analysis of retrievals located in Tibetan plateau is provided as an example to justify the robustness and performance of retrieving model.展开更多
Considering that at present the regular waves in common use have the profile symmetrized to a vertical axis, which are different from actual wind-driven sea waves, and based on deriving linear wave, solitary wave, fif...Considering that at present the regular waves in common use have the profile symmetrized to a vertical axis, which are different from actual wind-driven sea waves, and based on deriving linear wave, solitary wave, fifth order Stokes wave and stream function wave by using Unified Variational Principle of Water Gravity Wave (UVPWGW), this paper derives wind-driven slanting profile wave by using UVPWGW. Its feature is that under the action of wind pressure, the wave profile is not symmetrized to a vertical axis, but that it is in the forward slanting form.展开更多
Breast neoplasms are the main oncological pathology in Gynecology and Obstetrics, with increasing rates of incidence and mortality in the female population. According to the World Health Organization (WHO), more than ...Breast neoplasms are the main oncological pathology in Gynecology and Obstetrics, with increasing rates of incidence and mortality in the female population. According to the World Health Organization (WHO), more than 1 million new cases of breast cancer are diagnosed worldwide every year. This study aims to understand and analyze the epidemiological profile of patients diagnosed with breast cancer in the last nine years in the city of Valen<span style="white-space:nowrap;">ç</span>a—RJ, Brazil. A descriptive, documentary-retrospective analysis was carried out from January 2009 to December 2017, on 96 records of women who underwent breast biopsy at the Escola Escola de Valen<span style="white-space:nowrap;">ç</span>a (HEV), referred by the HEV Gynecology outpatient clinic. The results compared the variables age, race, parity, alcoholism, smoking, comorbidities, histological type, family history and screening performed with the scenario of breast cancer in the world, concluding that it is essential to identify patients at risk development of breast cancer to guide prevention, screening and early detection of pathology. The cases in the municipality are similar to other studies in relation to smoking, alcohol consumption, associated comorbidities, histological type and family history. However, the prevalence in younger people stands out, as well as the high percentage of women who have not had previous screening, which highlights the importance of the development and spread of women’s health in this city in the south of the state.展开更多
Fruit juice production sector is developing in Benin’s major cities and appears to have both organisational and technical shortcomings. This study aimed to 1) establish the socio-professional profile of actors in the...Fruit juice production sector is developing in Benin’s major cities and appears to have both organisational and technical shortcomings. This study aimed to 1) establish the socio-professional profile of actors in the fruit juice production sector in Abomey-Calavi and Cotonou municipalities and 2) evaluate the adoption level of hygienic practices of enterprises. The methodological approach adopted in this study combined a semi-structured survey with direct observations in fifty enterprises. The statistical analysis was carried out using the R.4.0.0 software. The study revealed that fruit juice enterprises in both municipalities are mainly artisanal (90%) and located in residential areas (94%). They are therefore exposed to contamination risks from domestic and road activities. More than half of these enterprises were created less than five years ago. Three administrative types of enterprises were noted: non-structured (32%), semi-structured (34%) and structured (34%). Almost half of the enterprises belong to at least one professional association. Only a few enterprises have marketing authorization. Women predominate in the positions of director and production assistant. The majority of production managers are men. Most directors and production managers have a university education, but not necessarily in the field of food sciences. The adoption level of hygienic practices is significantly influenced by the level of enterprises structuration and size. The level of hygiene in these enterprises is also very weakly influenced by the female gender. Structured and semi-industrial enterprises have a higher adoption level of hygienic practices. Those with acceptable or good hygiene level enterprises contain slightly more women.展开更多
The transmission characteristics of gear drive can be improved with the use of novel tooth profiles.A theoretical study on tooth profile of the hypocycloid pinwheel transmission and contact analysis of gear pair based...The transmission characteristics of gear drive can be improved with the use of novel tooth profiles.A theoretical study on tooth profile of the hypocycloid pinwheel transmission and contact analysis of gear pair based on finite element method(FEM) are carried out,respectively.The line contact between mated tooth surfaces becomes point contact according to a plus movement.Through loaded tooth contact analysis(LTCA),the contact stress and load distributions for the proposed hypocycloid pinwheel transmission and the traditional one are discussed.The analysis results show that the developed tooth surfaces have anticipatory point contact characteristics under loads and contact fatigue dangerous area locates around the ultimate contact position.展开更多
The study aimed to evaluate the effect of operating parameters of the sprinkler Super 10, manufactured by NaanDanJain, with green, yellow and blue nozzles on the hydraulic characterization, so that this information ca...The study aimed to evaluate the effect of operating parameters of the sprinkler Super 10, manufactured by NaanDanJain, with green, yellow and blue nozzles on the hydraulic characterization, so that this information can contribute to a better dimensioning of systems and management of irrigated areas. For the determination of UC and UD the radial method was used and with the aid of computer application CATCH 3D the overlapping of water slides with ten spacings was calculated. The results demonstrate that the mechanism used for the fractionation of the water jet of sprinkler Super 10 is efficient because it presented good uniformity of water distribution and low amplitude of precipitation. For high uniformity of distribution of water in the larger wetting radii, it is recommended to work with Super 10 sprinkler using the green nozzle, with a pressure of 40 mH2O and spacing between sprinklers and lateral lines 12 × 12 m.展开更多
HIV/AIDS has brought to light the challenge of incorporating the many influences between living conditions, social characteristics and health services performance to an adequate care for PLWHA （people living with AID...HIV/AIDS has brought to light the challenge of incorporating the many influences between living conditions, social characteristics and health services performance to an adequate care for PLWHA （people living with AIDS）. Vulnerability of these populations is under the responsibility of specialized care units whose assistance does not always occur according to their real needs and demands. Therefore, this study aimed to analyze demographic, social and clinical profiles of PLWHA, as well as their follow-up in SS （Specialized Health Services） in Ribeir^o Preto, Brazil. It is a descriptive study conducted by the application of structured questionnaires to 253 patients with HIV/AIDS in follow-up during the years of 2012-2013. Variables were analyzed by descriptive statistics procedures. The findings pointed out gender parity, aging population, low education and economic predominance of class C. Regarding clinical characteristics, there was a predominance of asymptomatic individuals, with no clinical manifestations of AIDS or major comorbidities. The main mode of transmission was through sexual contact. The results led to the need of adequating the assistance provided to the specificities inherent to PLWHA. The care provision should cross an interdisciplinary perspective, targeting recognition of problems and ensuring comprehensive health care adequate to users＇ needs and demands.展开更多
The key factors of temporal and spatial resolution for typhoon observation played an important role in the design of radiometer used for observing typhoon. The NCEP (National Centres for Environmental Prediction) oper...The key factors of temporal and spatial resolution for typhoon observation played an important role in the design of radiometer used for observing typhoon. The NCEP (National Centres for Environmental Prediction) operational global analysis data prepared operationally every six hours were used as the initial field for mesoscale weather research and forecasting model (WRF) and drove the model to output atmospheric parameters such as hydrometeor content, temperature and humidity profiles at different time, which were inputs for the Atmospheric Radiative Transfer Simulator (ARTS) to calculate brightness temperature observed from geostationary earth orbit at oxygen absorption and water absorption band. The atmospheric humidity and temperature profiles of typhoon domain were retrieved from geostationary sub-millimetre atmospheric sounder. The results show that the profile retrievals using BP-NN algorithm have a best agreement with those from radiosonde, which is less than 20% and 1 K of root mean square error, respectively. For precipitation rate retrievals, much better agreement with rain gauge and ECMWF datasets, the RMS is between 0.84 to 32.4 mm/h for sea surface 0.89 and 36.13 mm/h for land surface according to the classification by precipitation type.展开更多
This research aimed to overcome challenges such as high costs,lengthy optimization time,and low efficiency in resolving issues related to wheel-rail contact,rail wear,and vehicle dynamics.Based on the wheel-rail conta...This research aimed to overcome challenges such as high costs,lengthy optimization time,and low efficiency in resolving issues related to wheel-rail contact,rail wear,and vehicle dynamics.Based on the wheel-rail contact parameters,an optimal design method for rail grinding target profile is proposed from wear profile measurement to grinding profile design according to the actual railway track and vehicle operating conditions.We utilized Isight to create a simulation test and developed an RBF proxy model that incorporated both mechanical and geometric aspects of wheel-rail contact.By integrating rail modeling,wheel-rail contact analysis,and multi-objective optimization,we established a rail grinding optimization model that was solved using the NSGA-II algorithm.After optimization,the study achieved a 31.863%reduction in average contact stress,a 70.5%reduction in matching wear work,and a 100.391%increase in the difference in rolling radius between the wheel and rail.展开更多
Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering va...Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering valuable insights into tumor biology and potential treatment strategies.Methods:We conducted a comprehensive multi-omics analysis of 132 patients with American Joint Committee on Cancer(AJCC)stage III TNBC,comprising 36 long-term survivors(RFS≥8 years),62 moderate-term survivors(RFS:3-8 years),and 34 short-term survivors(RFS<3 years).Analyses investigated clinicopathological factors,whole-exome sequencing,germline mutations,copy number alterations(CNAs),RNA sequences,and metabolomic profiles.Results:Long-term survivors exhibited fewer metastatic regional lymph nodes,along with tumors showing reduced stromal fibrosis and lower Ki67 index.Molecularly,these tumors exhibited multiple alterations in genes related to homologous recombination repair,with higher frequencies of germline mutations and somatic CNAs.Additionally,tumors from long-term survivors demonstrated significant downregulation of the RTK-RAS signaling pathway.Metabolomic profiling revealed decreased levels of lipids and carbohydrate,particularly those involved in glycerophospholipid,fructose,and mannose metabolism,in long-term survival group.Multivariate Cox analysis identified fibrosis[hazard ratio(HR):12.70,95%confidence interval(95%CI):2.19-73.54,P=0.005]and RAC1copy number loss/deletion(HR:0.22,95%CI:0.06-0.83,P=0.026)as independent predictors of RFS.Higher fructose/mannose metabolism was associated with worse overall survival(HR:1.30,95%CI:1.01-1.68,P=0.045).Our findings emphasize the association between biological determinants and prolonged survival in patients with TNBC.Conclusions:Our study systematically identified the key molecular and metabolic features associated with prolonged survival in AJCC stage III TNBC,suggesting potential therapeutic targets to improve patient outcomes.展开更多
The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficien...The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficiency and low-cost manufacturing of the component.Blank design is the key part of plastic forming process design.For spinning-rolling process,the shape and size of the blank play a crucial role in process stability,deformation behavior and dimensional accuracy.So this work proposes a blank design method to determine the geometry structure and sizes of the blank.The mathematical model for calculating the blank size has been deduced based on volume conservation and neutral layer length invariance principle.The FE simulation and corresponding trial production of an actual big-tapered profiled ring disk show that the proposed blank design method is applicative.In order to obtain a preferred blank,the influence rules of blank size determined by different deformation degrees(rolling ratio k)on the spinning-rolling process are revealed by comprehensive FE simulations.Overall considering the process stability,circularity of the deformed ring disk and forming forces,a reasonable range of deformation degree(rolling ratio k)is recommended for the blank design of the new spinning-rolling process.展开更多
CO_(2)-responsive gels,which swell upon contact with CO_(2),are widely used for profile control to plug high-permeability gas flow channels in carbon capture,utilization,and storage(CCUS)applications in oil reser-voir...CO_(2)-responsive gels,which swell upon contact with CO_(2),are widely used for profile control to plug high-permeability gas flow channels in carbon capture,utilization,and storage(CCUS)applications in oil reser-voirs.However,the use of these gels in high-temperature CCUS applications is limited due to their rever-sible swelling behavior at elevated temperatures.In this study,a novel dispersed particle gel(DPG)suspension is developed for high-temperature profile control in CCUS applications.First,we synthesize a double-network hydrogel consisting of a crosslinked polyacrylamide(PAAm)network and a crosslinked sodium alginate(SA)network.The hydrogel is then sheared in water to form a pre-prepared DPG suspen-sion.To enhance its performance,the gel particles are modified by introducing potassium methylsilan-etriolate(PMS)upon CO_(2) exposure.Comparing the particle size distributions of the modified and pre-prepared DPG suspension reveals a significant swelling of gel particles,over twice their original size.Moreover,subjecting the new DPG suspension to a 100℃ environment for 24 h demonstrates that its gel particle sizes do not decrease,confirming irreversible swelling,which is a significant advantage over the traditional CO_(2)-responsive gels.Thermogravimetric analysis further indicates improved thermal sta-bility compared to the pre-prepared DPG particles.Core flooding experiments show that the new DPG suspension achieves a high plugging efficiency of 95.3%in plugging an ultra-high permeability sandpack,whereas the pre-prepared DPG suspension achieves only 82.8%.With its high swelling ratio,irreversible swelling at high temperatures,enhanced thermal stability,and superior plugging performance,the newly developed DPG suspension in this work presents a highly promising solution for profile control in high-temperature CCUS applications.展开更多
A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance m...A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance method.Firstly,an altitude-energy profile is designed,and the bank angle is derived analytically as the initial iteration value for the predictor-corrector method.The predictor-corrector guidance method has been improved by deriving an analytical form for predicting the range-to-go error,which greatly accelerates the iterative speed.Then,a segmented guidance algorithm is proposed.The above analytically predictor-corrector guidance method is adopted when the energy exceeds an energy threshold.When the energy is less than the threshold,the equidistant test method is used to calculate the bank angle command,which ensures guidance accuracy as well as computational efficiency.Additionally,an adaptive guidance cycle strategy is applied to reduce the computational time of the reentry guidance trajectory.Finally,the accuracy and robustness of the proposed method are verified through a series of simulations and Monte-Carlo experiments.Compared with the traditional integral method,the proposed method requires 75%less computation time on average and achieves a lower landing error.展开更多
Fast reciprocating probe systems （ FRPS ） are widely used in some tokamaks, such as JT- 60 U, TEXT and DIlI-D. The parameters with high temporal-spatial resolution are measured for boundary plasmas using these syste...Fast reciprocating probe systems （ FRPS ） are widely used in some tokamaks, such as JT- 60 U, TEXT and DIlI-D. The parameters with high temporal-spatial resolution are measured for boundary plasmas using these systems. The FRPS on HL-2A is developed, which is composed of transmission bar, digital grating displacement system, electromagnetic valves, stepping motor and so on. The high-pressure gas from the electromagnetic valves controlled by trigger signals provides the power to drive the transmission bar forward or backward. Reciprocating distance is 8 cm with the maximum speed of 1.5 m·s^-1.展开更多
Objectives:SocialNetworkAddiction(SNA)is becoming increasingly prevalent among college students;however,there remains a lack of consensus regarding the measurement tools and their optimal cutoff score.This study aims ...Objectives:SocialNetworkAddiction(SNA)is becoming increasingly prevalent among college students;however,there remains a lack of consensus regarding the measurement tools and their optimal cutoff score.This study aims to validate the 21-item SocialNetwork Addiction Scale-Chinese(SNAS-C)in its Chinese version and to determine its optimal cutoff score for identifying potential SNA cases within the college student population.Methods:A crosssectional survey was conducted,recruiting 3387 college students.Latent profile analysis(LPA)and receiver operating characteristic(ROC)curve analysis were employed to establish the optimal cutoff score for the validated 21-item SNAS-C.Results:Three profile models were selected based on multiple statistical criteria,classifying participants into low-risk,moderate-risk,and high-risk groups.The highest-risk group was defined as“positive”for SNA,while the remaining groups were considered“negative”,serving as the reference standard for ROC analysis.The optimal cutoff score was determined to be 72(sensitivity:98.2%,specificity:96.86%),with an overall classification accuracy of 97.0%.The“positive”group reported significantly higher frequency of social network usage,greater digitalmedia dependence scores,and a higher incidence of network addiction.Conclusion:This study identified the optimal cutoff score for the SNAS-C as≥72,demonstrating high sensitivity,specificity,and diagnostic accuracy.This threshold effectively distinguishes between high-risk and low-risk SNA.展开更多
基金financially supported by the National Natural Science Foundation of China(No.52005431)the National Natural Science Foundation of Hebei Province,China(No.E2020203086)the National Major Science and Technology Project of China(No.2018ZX04007002).
文摘A multi-point flexible straightening process characterized by reciprocating bending is proposed.Specifically,the process is analyzed in terms of deformation mechanism and verified by numerical simulations and physical experiments of the straightening of a series of metal profiles with different materials and initial shapes.Further,the relationship between the bending radius and the times of reciprocating bending required to unify the curvature is discussed,and the distribution of residual stress after straightening is analyzed.The results show that the reciprocating bending process can eliminate the difference of the initial curvature,make the curvature of each section tend to be uniform;the times of reciprocating bending to reach the uniform curvature decreases with the decrease of bending radius.The straightness of the straightened profile obtained from the experiment and simulation is less than 0.2%,demonstrating a good feasibility of this method.
文摘In this paper, some distinctive features of the vertical profile of precipitable liquid water content (LWC) with considerable respect to rain rates (R) and radar reflectivity (Z) obtained in a tropical location are presented. Assessment of LWC allows applications in the specific area of flight icing severity, aviation safety as well as signals traversing through the atmosphere. The parameters were typically measured using vertically-pointing Micro Rain Radar (MRR) over a period of 2 years (2011-2012) at Akure, a tropical location of Nigeria. The radar scanned at every 10 seconds and integrated over one minute samples to reduce event logging error associated with the instrument. The vertical profile of the LWC typically reveals a prominent seasonal variation. However, majority of the LWC profiles has low LWC, less than 0.1 gm?3 while the maximum observed LWC is about 3.18 gm?3. A strong like hood relation was observed between the melting layer height and the LWC, with the LWC reaches peak at the considerable height of about 4160 m which coincides precisely with the freezing height level (rain height of ~4520 m) of the study location. Good correlation was also observed between the LWC and R in most of the heights considered. The results obtained will assist system engineers to assess the level of absorption, reflection and attenuation of electromagnetic signals as a result of precipitable LWC along the transmitting paths. The novelty of the present work is in the area of linking LWC and Z as against usual relation between Z and R.
文摘The 89 and 150 GHz channels operated in window are sensitive to precipitation and humidity. The 183 GHz humidity-sensitive channels and 118 GHz temperature-sensitive channels of the Microwave Humidity and Temperature Sounder (MWHTS) on the Chinese Feng Yun 3C MWHTS (FY-3C MWHTS) polar-orbit meteorological satellite responds in part to precipitation. Combining 118 and 183 GHz channels, the paper develops a passive sub-millimeter atmospheric profile and precipitation retrievals algorithm for MWHTS onboard the FY-3C (Feng Yun-3C) satellite. The retrieval algorithm employs a number of back propagation neural network estimators trained and evaluated using the validated global reference physical model NCEP/WRF/ARTS and works for land and seawater with latitude between -40 to 40 degree. NCEP data per 6 hours were downloaded to run the Weather Research and Forecast model WRF, and to derive the typical precipitation data for the whole world. The Atmospheric Radiative Transfer Simulator ARTS is feasible for performing simulations of atmospheric radiative transfer. The results show that the profile retrievals using BP-NN algorithm has the best correlation with those from radiosonde, which is less than 18% and 1 K of root mean square error, respectively. For precipitation rate retrievals, a much better agreement is reached with rain gauge and ECMWF datasets, the RMS is between 0.80 to 30.24 mm/h for sea surface and 0.789 to 33.11 mm/h for land surface according to the classification by precipitation type. Also, the analysis of retrievals located in Tibetan plateau is provided as an example to justify the robustness and performance of retrieving model.
文摘Considering that at present the regular waves in common use have the profile symmetrized to a vertical axis, which are different from actual wind-driven sea waves, and based on deriving linear wave, solitary wave, fifth order Stokes wave and stream function wave by using Unified Variational Principle of Water Gravity Wave (UVPWGW), this paper derives wind-driven slanting profile wave by using UVPWGW. Its feature is that under the action of wind pressure, the wave profile is not symmetrized to a vertical axis, but that it is in the forward slanting form.
文摘Breast neoplasms are the main oncological pathology in Gynecology and Obstetrics, with increasing rates of incidence and mortality in the female population. According to the World Health Organization (WHO), more than 1 million new cases of breast cancer are diagnosed worldwide every year. This study aims to understand and analyze the epidemiological profile of patients diagnosed with breast cancer in the last nine years in the city of Valen<span style="white-space:nowrap;">ç</span>a—RJ, Brazil. A descriptive, documentary-retrospective analysis was carried out from January 2009 to December 2017, on 96 records of women who underwent breast biopsy at the Escola Escola de Valen<span style="white-space:nowrap;">ç</span>a (HEV), referred by the HEV Gynecology outpatient clinic. The results compared the variables age, race, parity, alcoholism, smoking, comorbidities, histological type, family history and screening performed with the scenario of breast cancer in the world, concluding that it is essential to identify patients at risk development of breast cancer to guide prevention, screening and early detection of pathology. The cases in the municipality are similar to other studies in relation to smoking, alcohol consumption, associated comorbidities, histological type and family history. However, the prevalence in younger people stands out, as well as the high percentage of women who have not had previous screening, which highlights the importance of the development and spread of women’s health in this city in the south of the state.
文摘Fruit juice production sector is developing in Benin’s major cities and appears to have both organisational and technical shortcomings. This study aimed to 1) establish the socio-professional profile of actors in the fruit juice production sector in Abomey-Calavi and Cotonou municipalities and 2) evaluate the adoption level of hygienic practices of enterprises. The methodological approach adopted in this study combined a semi-structured survey with direct observations in fifty enterprises. The statistical analysis was carried out using the R.4.0.0 software. The study revealed that fruit juice enterprises in both municipalities are mainly artisanal (90%) and located in residential areas (94%). They are therefore exposed to contamination risks from domestic and road activities. More than half of these enterprises were created less than five years ago. Three administrative types of enterprises were noted: non-structured (32%), semi-structured (34%) and structured (34%). Almost half of the enterprises belong to at least one professional association. Only a few enterprises have marketing authorization. Women predominate in the positions of director and production assistant. The majority of production managers are men. Most directors and production managers have a university education, but not necessarily in the field of food sciences. The adoption level of hygienic practices is significantly influenced by the level of enterprises structuration and size. The level of hygiene in these enterprises is also very weakly influenced by the female gender. Structured and semi-industrial enterprises have a higher adoption level of hygienic practices. Those with acceptable or good hygiene level enterprises contain slightly more women.
基金National Natural Science Foundation of China(No.51205425)National Science&Technology Pillar Program during the 12th Five-Year Plan Period of China(No.2013BAF01B04)
文摘The transmission characteristics of gear drive can be improved with the use of novel tooth profiles.A theoretical study on tooth profile of the hypocycloid pinwheel transmission and contact analysis of gear pair based on finite element method(FEM) are carried out,respectively.The line contact between mated tooth surfaces becomes point contact according to a plus movement.Through loaded tooth contact analysis(LTCA),the contact stress and load distributions for the proposed hypocycloid pinwheel transmission and the traditional one are discussed.The analysis results show that the developed tooth surfaces have anticipatory point contact characteristics under loads and contact fatigue dangerous area locates around the ultimate contact position.
文摘The study aimed to evaluate the effect of operating parameters of the sprinkler Super 10, manufactured by NaanDanJain, with green, yellow and blue nozzles on the hydraulic characterization, so that this information can contribute to a better dimensioning of systems and management of irrigated areas. For the determination of UC and UD the radial method was used and with the aid of computer application CATCH 3D the overlapping of water slides with ten spacings was calculated. The results demonstrate that the mechanism used for the fractionation of the water jet of sprinkler Super 10 is efficient because it presented good uniformity of water distribution and low amplitude of precipitation. For high uniformity of distribution of water in the larger wetting radii, it is recommended to work with Super 10 sprinkler using the green nozzle, with a pressure of 40 mH2O and spacing between sprinklers and lateral lines 12 × 12 m.
文摘HIV/AIDS has brought to light the challenge of incorporating the many influences between living conditions, social characteristics and health services performance to an adequate care for PLWHA （people living with AIDS）. Vulnerability of these populations is under the responsibility of specialized care units whose assistance does not always occur according to their real needs and demands. Therefore, this study aimed to analyze demographic, social and clinical profiles of PLWHA, as well as their follow-up in SS （Specialized Health Services） in Ribeir^o Preto, Brazil. It is a descriptive study conducted by the application of structured questionnaires to 253 patients with HIV/AIDS in follow-up during the years of 2012-2013. Variables were analyzed by descriptive statistics procedures. The findings pointed out gender parity, aging population, low education and economic predominance of class C. Regarding clinical characteristics, there was a predominance of asymptomatic individuals, with no clinical manifestations of AIDS or major comorbidities. The main mode of transmission was through sexual contact. The results led to the need of adequating the assistance provided to the specificities inherent to PLWHA. The care provision should cross an interdisciplinary perspective, targeting recognition of problems and ensuring comprehensive health care adequate to users＇ needs and demands.
文摘The key factors of temporal and spatial resolution for typhoon observation played an important role in the design of radiometer used for observing typhoon. The NCEP (National Centres for Environmental Prediction) operational global analysis data prepared operationally every six hours were used as the initial field for mesoscale weather research and forecasting model (WRF) and drove the model to output atmospheric parameters such as hydrometeor content, temperature and humidity profiles at different time, which were inputs for the Atmospheric Radiative Transfer Simulator (ARTS) to calculate brightness temperature observed from geostationary earth orbit at oxygen absorption and water absorption band. The atmospheric humidity and temperature profiles of typhoon domain were retrieved from geostationary sub-millimetre atmospheric sounder. The results show that the profile retrievals using BP-NN algorithm have a best agreement with those from radiosonde, which is less than 20% and 1 K of root mean square error, respectively. For precipitation rate retrievals, much better agreement with rain gauge and ECMWF datasets, the RMS is between 0.84 to 32.4 mm/h for sea surface 0.89 and 36.13 mm/h for land surface according to the classification by precipitation type.
基金Supported by Fundamental Research Funds for the Central Universities(Grant No.2019JBM050).
文摘This research aimed to overcome challenges such as high costs,lengthy optimization time,and low efficiency in resolving issues related to wheel-rail contact,rail wear,and vehicle dynamics.Based on the wheel-rail contact parameters,an optimal design method for rail grinding target profile is proposed from wear profile measurement to grinding profile design according to the actual railway track and vehicle operating conditions.We utilized Isight to create a simulation test and developed an RBF proxy model that incorporated both mechanical and geometric aspects of wheel-rail contact.By integrating rail modeling,wheel-rail contact analysis,and multi-objective optimization,we established a rail grinding optimization model that was solved using the NSGA-II algorithm.After optimization,the study achieved a 31.863%reduction in average contact stress,a 70.5%reduction in matching wear work,and a 100.391%increase in the difference in rolling radius between the wheel and rail.
基金supported by grants from the Medical Engineering Jiont Fund of the Fudan University(No.IDH2310117)。
文摘Objective:Triple-negative breast cancer(TNBC)is a highly aggressive subtype that lacks targeted therapies,leading to a poorer prognosis.However,some patients achieve long-term recurrence-free survival(RFS),offering valuable insights into tumor biology and potential treatment strategies.Methods:We conducted a comprehensive multi-omics analysis of 132 patients with American Joint Committee on Cancer(AJCC)stage III TNBC,comprising 36 long-term survivors(RFS≥8 years),62 moderate-term survivors(RFS:3-8 years),and 34 short-term survivors(RFS<3 years).Analyses investigated clinicopathological factors,whole-exome sequencing,germline mutations,copy number alterations(CNAs),RNA sequences,and metabolomic profiles.Results:Long-term survivors exhibited fewer metastatic regional lymph nodes,along with tumors showing reduced stromal fibrosis and lower Ki67 index.Molecularly,these tumors exhibited multiple alterations in genes related to homologous recombination repair,with higher frequencies of germline mutations and somatic CNAs.Additionally,tumors from long-term survivors demonstrated significant downregulation of the RTK-RAS signaling pathway.Metabolomic profiling revealed decreased levels of lipids and carbohydrate,particularly those involved in glycerophospholipid,fructose,and mannose metabolism,in long-term survival group.Multivariate Cox analysis identified fibrosis[hazard ratio(HR):12.70,95%confidence interval(95%CI):2.19-73.54,P=0.005]and RAC1copy number loss/deletion(HR:0.22,95%CI:0.06-0.83,P=0.026)as independent predictors of RFS.Higher fructose/mannose metabolism was associated with worse overall survival(HR:1.30,95%CI:1.01-1.68,P=0.045).Our findings emphasize the association between biological determinants and prolonged survival in patients with TNBC.Conclusions:Our study systematically identified the key molecular and metabolic features associated with prolonged survival in AJCC stage III TNBC,suggesting potential therapeutic targets to improve patient outcomes.
基金the National Natural Science Foundation of China(No.52275378)the National Key Laboratory for Precision Hot Processing of Metals(6142909200208)。
文摘The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficiency and low-cost manufacturing of the component.Blank design is the key part of plastic forming process design.For spinning-rolling process,the shape and size of the blank play a crucial role in process stability,deformation behavior and dimensional accuracy.So this work proposes a blank design method to determine the geometry structure and sizes of the blank.The mathematical model for calculating the blank size has been deduced based on volume conservation and neutral layer length invariance principle.The FE simulation and corresponding trial production of an actual big-tapered profiled ring disk show that the proposed blank design method is applicative.In order to obtain a preferred blank,the influence rules of blank size determined by different deformation degrees(rolling ratio k)on the spinning-rolling process are revealed by comprehensive FE simulations.Overall considering the process stability,circularity of the deformed ring disk and forming forces,a reasonable range of deformation degree(rolling ratio k)is recommended for the blank design of the new spinning-rolling process.
基金Lin Du acknowledges the financial support provided by China Scholarship Council(CSC)via a Ph.D.Scholarship(202008510128)supported by Core Technology Project of China National Petroleum Corporation(CNPC)"Research on Thermal Miscible Flooding Technology"(2023ZG18)。
文摘CO_(2)-responsive gels,which swell upon contact with CO_(2),are widely used for profile control to plug high-permeability gas flow channels in carbon capture,utilization,and storage(CCUS)applications in oil reser-voirs.However,the use of these gels in high-temperature CCUS applications is limited due to their rever-sible swelling behavior at elevated temperatures.In this study,a novel dispersed particle gel(DPG)suspension is developed for high-temperature profile control in CCUS applications.First,we synthesize a double-network hydrogel consisting of a crosslinked polyacrylamide(PAAm)network and a crosslinked sodium alginate(SA)network.The hydrogel is then sheared in water to form a pre-prepared DPG suspen-sion.To enhance its performance,the gel particles are modified by introducing potassium methylsilan-etriolate(PMS)upon CO_(2) exposure.Comparing the particle size distributions of the modified and pre-prepared DPG suspension reveals a significant swelling of gel particles,over twice their original size.Moreover,subjecting the new DPG suspension to a 100℃ environment for 24 h demonstrates that its gel particle sizes do not decrease,confirming irreversible swelling,which is a significant advantage over the traditional CO_(2)-responsive gels.Thermogravimetric analysis further indicates improved thermal sta-bility compared to the pre-prepared DPG particles.Core flooding experiments show that the new DPG suspension achieves a high plugging efficiency of 95.3%in plugging an ultra-high permeability sandpack,whereas the pre-prepared DPG suspension achieves only 82.8%.With its high swelling ratio,irreversible swelling at high temperatures,enhanced thermal stability,and superior plugging performance,the newly developed DPG suspension in this work presents a highly promising solution for profile control in high-temperature CCUS applications.
基金National Natural Science Foundation of China(Nos.61773387 and 62022061).
文摘A segmented predictor-corrector method is proposed for hypersonic glide vehicles to address the issue of the slow computational speed of obtaining guidance commands using the traditional predictor-corrector guidance method.Firstly,an altitude-energy profile is designed,and the bank angle is derived analytically as the initial iteration value for the predictor-corrector method.The predictor-corrector guidance method has been improved by deriving an analytical form for predicting the range-to-go error,which greatly accelerates the iterative speed.Then,a segmented guidance algorithm is proposed.The above analytically predictor-corrector guidance method is adopted when the energy exceeds an energy threshold.When the energy is less than the threshold,the equidistant test method is used to calculate the bank angle command,which ensures guidance accuracy as well as computational efficiency.Additionally,an adaptive guidance cycle strategy is applied to reduce the computational time of the reentry guidance trajectory.Finally,the accuracy and robustness of the proposed method are verified through a series of simulations and Monte-Carlo experiments.Compared with the traditional integral method,the proposed method requires 75%less computation time on average and achieves a lower landing error.
文摘Fast reciprocating probe systems （ FRPS ） are widely used in some tokamaks, such as JT- 60 U, TEXT and DIlI-D. The parameters with high temporal-spatial resolution are measured for boundary plasmas using these systems. The FRPS on HL-2A is developed, which is composed of transmission bar, digital grating displacement system, electromagnetic valves, stepping motor and so on. The high-pressure gas from the electromagnetic valves controlled by trigger signals provides the power to drive the transmission bar forward or backward. Reciprocating distance is 8 cm with the maximum speed of 1.5 m·s^-1.
基金supported by the National Natural Science Foundation of China(Grant No.72364006).
文摘Objectives:SocialNetworkAddiction(SNA)is becoming increasingly prevalent among college students;however,there remains a lack of consensus regarding the measurement tools and their optimal cutoff score.This study aims to validate the 21-item SocialNetwork Addiction Scale-Chinese(SNAS-C)in its Chinese version and to determine its optimal cutoff score for identifying potential SNA cases within the college student population.Methods:A crosssectional survey was conducted,recruiting 3387 college students.Latent profile analysis(LPA)and receiver operating characteristic(ROC)curve analysis were employed to establish the optimal cutoff score for the validated 21-item SNAS-C.Results:Three profile models were selected based on multiple statistical criteria,classifying participants into low-risk,moderate-risk,and high-risk groups.The highest-risk group was defined as“positive”for SNA,while the remaining groups were considered“negative”,serving as the reference standard for ROC analysis.The optimal cutoff score was determined to be 72(sensitivity:98.2%,specificity:96.86%),with an overall classification accuracy of 97.0%.The“positive”group reported significantly higher frequency of social network usage,greater digitalmedia dependence scores,and a higher incidence of network addiction.Conclusion:This study identified the optimal cutoff score for the SNAS-C as≥72,demonstrating high sensitivity,specificity,and diagnostic accuracy.This threshold effectively distinguishes between high-risk and low-risk SNA.
