Neutrophils,bone marrow-derived innate immune cells,are among the first defensive and inflammatory responses of the host to infection and other danger signals.Increasing evidence indicates that neutrophils are critica...Neutrophils,bone marrow-derived innate immune cells,are among the first defensive and inflammatory responses of the host to infection and other danger signals.Increasing evidence indicates that neutrophils are critically involved in shaping adaptive immunity as professional antigen-presenting cells(APCs).1–3 However,neutrophils also negatively regulate inflammatory and immune responses or promote tissue repair and wound healing through multiple approaches.3–5 With the widely diverse roles of neutrophils in host homeostasis and diseases,it is necessary to identify new subsets of functionally different neutrophils.Interestingly and importantly,Li et al.6 and Sun et al.7 recently identified N(IL-23)and N(IL-33)subsets,respectively.These findings are of importance for us to fully understand the biological diversity of neutrophils and,even more importantly,could reveal the wider functional polarization of neutrophils beyond the traditional N1/N2 bidirectional polarization.展开更多
基金supported by grants from the National Key Research and Development Program of China(2017YFA0105002 and 2017YFA0104402 to Y.Z.)Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030301)+2 种基金the Chinese Government 13th Five-Year Plan(2017ZX10201101)the National Natural Science Foundation for General and Key Programs(C81530049,U1738111,and C31470860 to Y.Z.)the China Manned Space Flight Technology Project(TZ-1 to Y.Z.).
文摘Neutrophils,bone marrow-derived innate immune cells,are among the first defensive and inflammatory responses of the host to infection and other danger signals.Increasing evidence indicates that neutrophils are critically involved in shaping adaptive immunity as professional antigen-presenting cells(APCs).1–3 However,neutrophils also negatively regulate inflammatory and immune responses or promote tissue repair and wound healing through multiple approaches.3–5 With the widely diverse roles of neutrophils in host homeostasis and diseases,it is necessary to identify new subsets of functionally different neutrophils.Interestingly and importantly,Li et al.6 and Sun et al.7 recently identified N(IL-23)and N(IL-33)subsets,respectively.These findings are of importance for us to fully understand the biological diversity of neutrophils and,even more importantly,could reveal the wider functional polarization of neutrophils beyond the traditional N1/N2 bidirectional polarization.
