Receptor for advanced glycosylation end products(RAGE)is an essential cell surface receptor that detects advanced glycation end products(AGEs)to mediate important inflammatory and immune processes.Inflammation can cau...Receptor for advanced glycosylation end products(RAGE)is an essential cell surface receptor that detects advanced glycation end products(AGEs)to mediate important inflammatory and immune processes.Inflammation can cause insulin resistance,in which the excess glucose in the blood that cannot be stored as fat induces hyperglycemia.Under these conditions,AGEs,high mobility group box 1,S100s,and other inflammatory factors induce the production of tumor necrosis factor-α,interleukin-1β,interleukin(interleukin-6),and other proinflammatory cytokines,inducing chronic inflammation.Herein,we reviewed the relationships between diabetes and RAGE-related inflammation and the associated signaling pathways.Recent progress in targeted therapy against RAGE has also been discussed.Since RAGE is involved in the progression of diabetes,it might be a promising therapeutic target for the prevention and management of this disorder and related complications.展开更多
基金supported by the National Natural Science Foundation of China(No.22177030).
文摘Receptor for advanced glycosylation end products(RAGE)is an essential cell surface receptor that detects advanced glycation end products(AGEs)to mediate important inflammatory and immune processes.Inflammation can cause insulin resistance,in which the excess glucose in the blood that cannot be stored as fat induces hyperglycemia.Under these conditions,AGEs,high mobility group box 1,S100s,and other inflammatory factors induce the production of tumor necrosis factor-α,interleukin-1β,interleukin(interleukin-6),and other proinflammatory cytokines,inducing chronic inflammation.Herein,we reviewed the relationships between diabetes and RAGE-related inflammation and the associated signaling pathways.Recent progress in targeted therapy against RAGE has also been discussed.Since RAGE is involved in the progression of diabetes,it might be a promising therapeutic target for the prevention and management of this disorder and related complications.
