The gram-scale preparation of efficient polyoxometalate catalysts is an everlasting yet challenging goal for sustainable organic conversion processes.Herein we report a facile ball-milling strategy to prepare polyoxon...The gram-scale preparation of efficient polyoxometalate catalysts is an everlasting yet challenging goal for sustainable organic conversion processes.Herein we report a facile ball-milling strategy to prepare polyoxoniobate-intercalated layered double hydroxide(Mg_(3)Al-LDH-Nb_(6))that shows quite high catalytic activity for the Aldol and Michael addition cascade reactions,e.g.selective synthesis of polysubstituted cyclohexanols and 1,5-diones from arylaldehydes and arylketones.The gram-scale preparation and high reusability with negligible loss of catalytic activity of the Mg_(3)Al-LDH-Nb_(6) catalyst would greatly promote its industrial applications.Additionally,some catalysts exhibit good inhibition effects against human cervix tumor cells(HeLa)and lung cancer human alveolar basal epithelial cells(A549).This work not only develops a facile method for the gram-scale preparation of a new polyoxoniobate-intercalated layered double hydroxide catalyst but also highlights promising biological applications of the catalytic products.展开更多
基金financially supported by the National Natural Science Foundation of China(nos 21871125,22171139,21801145 and 21901122)the Natural Science Foundation of Shandong Province,China(nos ZR2019MB043 and ZR2019QB022)+1 种基金the Shandong Provincial Key R&D Program/Major Science and Technology Innovation Project of Shandong Province(2019JZZY020230)the Construction Project of Quality Curriculum for Postgraduate Education of Shandong Province(no.SDYKC19057).
文摘The gram-scale preparation of efficient polyoxometalate catalysts is an everlasting yet challenging goal for sustainable organic conversion processes.Herein we report a facile ball-milling strategy to prepare polyoxoniobate-intercalated layered double hydroxide(Mg_(3)Al-LDH-Nb_(6))that shows quite high catalytic activity for the Aldol and Michael addition cascade reactions,e.g.selective synthesis of polysubstituted cyclohexanols and 1,5-diones from arylaldehydes and arylketones.The gram-scale preparation and high reusability with negligible loss of catalytic activity of the Mg_(3)Al-LDH-Nb_(6) catalyst would greatly promote its industrial applications.Additionally,some catalysts exhibit good inhibition effects against human cervix tumor cells(HeLa)and lung cancer human alveolar basal epithelial cells(A549).This work not only develops a facile method for the gram-scale preparation of a new polyoxoniobate-intercalated layered double hydroxide catalyst but also highlights promising biological applications of the catalytic products.
