The tremendous success of mRNA vaccine during the COVID-19 pandemic has captured attention globally and highlighted the transformative potential of mRNA technology in addressing infectious diseases[1].In comparison to...The tremendous success of mRNA vaccine during the COVID-19 pandemic has captured attention globally and highlighted the transformative potential of mRNA technology in addressing infectious diseases[1].In comparison to conventional protein antibody-based therapies,the delivery of mRNA-encoding antibod-ies presents a cost-effective and versatile approach with several advantages.These include eliminating the laborious process of in vitro protein expression,enabling flexible manufacturing processes,and eliciting rapid therapeutic responses[2-4].However,the clinical application of mRNA-encoded antibodies for infectious diseases remains limited to date,only one such construct-mRNA-1944-has been assessed in non-human primates and approved for phase I clinical trial[5,6].Several challenges hampered the broader clinical application of mRNA-encoded antibody therapies,including the requirement for higher dosages for intravenous administration,limited pharmacodynamic and pharmacokinetics data,as well as the lack of safety and efficacy profiles in non-human primates[7].展开更多
Chemical Engineering has played an important role in developing our modern society.Here,it is discussed how this discipline also has been a cornerstone for development of the field of systems biology,that has signific...Chemical Engineering has played an important role in developing our modern society.Here,it is discussed how this discipline also has been a cornerstone for development of the field of systems biology,that has significantly impacted basic biological research,development of new biotechnological processes,and advancing human health in the last 10–15 years.展开更多
基金supported by the National Key Research and Development Project of China(2022YFC2304100 and 2021YFC2302400)the National Natural Science Foundation of China(82371833,82350801,and 82222041)+1 种基金Cheng-Feng Qin was supported by the National Science Fund for Distinguished Young Scholars(81925025)the Innovation Fund for Medical Sciences(2019-I2M-5-049)from the Chinese Academy of Medical Sciences.
文摘The tremendous success of mRNA vaccine during the COVID-19 pandemic has captured attention globally and highlighted the transformative potential of mRNA technology in addressing infectious diseases[1].In comparison to conventional protein antibody-based therapies,the delivery of mRNA-encoding antibod-ies presents a cost-effective and versatile approach with several advantages.These include eliminating the laborious process of in vitro protein expression,enabling flexible manufacturing processes,and eliciting rapid therapeutic responses[2-4].However,the clinical application of mRNA-encoded antibodies for infectious diseases remains limited to date,only one such construct-mRNA-1944-has been assessed in non-human primates and approved for phase I clinical trial[5,6].Several challenges hampered the broader clinical application of mRNA-encoded antibody therapies,including the requirement for higher dosages for intravenous administration,limited pharmacodynamic and pharmacokinetics data,as well as the lack of safety and efficacy profiles in non-human primates[7].
基金Open access funding enabled and orgarized by Chalmers University of Technology.
文摘Chemical Engineering has played an important role in developing our modern society.Here,it is discussed how this discipline also has been a cornerstone for development of the field of systems biology,that has significantly impacted basic biological research,development of new biotechnological processes,and advancing human health in the last 10–15 years.
