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Neurodegenerative processes of aging: A perspective of restoration through insulin-like growth factor-1
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作者 Rosana Crespo Claudia Herenu 《Neural Regeneration Research》 2026年第4期1562-1563,共2页
The aging process is an inexorable fact throughout our lives and is considered a major factor in develo ping neurological dysfunctions associated with cognitive,emotional,and motor impairments.Aging-associated neurode... The aging process is an inexorable fact throughout our lives and is considered a major factor in develo ping neurological dysfunctions associated with cognitive,emotional,and motor impairments.Aging-associated neurodegenerative diseases are characterized by the progressive loss of neuronal structure and function. 展开更多
关键词 neurodegenerative diseases neurodegenerative processes cognitive impairments progressive loss neuronal structure function develo ping neurological dysfunctions insulin growth factor RESTORATION aging process
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Could Increasing Minimally Processed Food Consumption Lower Body Fat Mass?
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作者 Zhenyu Yang 《Biomedical and Environmental Sciences》 2026年第1期1-2,共2页
Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^(... Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control. 展开更多
关键词 OBESITY public health minimally processed food body fat mass OVERWEIGHT global health China overweight obesity
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A peridynamics modeling approach for pre-cracked rock cracking processes under impact by integrating Drucker-Prager plasticity model and efficient contact model
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作者 Jingzhi Tu Nengxiong Xu Gang Mei 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期179-195,共17页
In rock engineering,natural cracks in rock masses subjected to external loads tend to initiate and propagate,leading to potential safety hazards.To investigate the effect of cracking behavior on the mechanical propert... In rock engineering,natural cracks in rock masses subjected to external loads tend to initiate and propagate,leading to potential safety hazards.To investigate the effect of cracking behavior on the mechanical properties of rocks,the cracking processes of pre-cracked rocks have been extensively studied using numerical modeling methods.The peridynamics(PD)exhibits advantages over other numerical methods due to the absence of the requirements for remeshing and external crack growth criterion.However,for modeling pre-cracked rock cracking processes under impact,current PD implementations lack generally applicable rock constitutive models and impact contact models,which leads to difficulties in determining rock material parameters and efficiently calculating impact loads.This paper proposes a non-ordinary state-based peridynamics(NOSBPD)modeling method integrating the Drucker-Prager(DP)plasticity model and an efficient contact model to address the above problems.In the proposed method,the Drucker-Prager plasticity model is integrated into the NOSBPD,thereby equipping NOSBPD with the capability to accurately characterize the nonlinear stress-strain relationship inherent in rocks.An efficient contact model between particles and meshes is designed to calculate the impact loads,which is essentially a coupling method of PD with the finite element method(FEM).The effectiveness of the proposed NOSBPD modeling method is verified by comparison with other numerical methods and experiments.Experimental results indicate that the proposed method can effectively and accurately predict the 3D cracking processes of pre-cracked cracks under impact loading,and the maximum principal stress is the key driver behind wing crack formation in pre-cracked rocks. 展开更多
关键词 Pre-cracked rocks Cracking processes Non-ordinary state-based peridynamics (NOSBPD) Drucker-Prager plasticity model Efficient contact model
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Vertical Interfacial Engineering in Two-Step-Processed Perovskite Films Enabled by Dual-Interface Modification for High-Efficiency p-i-n Solar Cells
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作者 Wenhao Zhou Heng Liu +8 位作者 Haiyan Li Weihai Zhang Hui Li Xia Zhou Rouxi Chen Wenjun Zhang Tingting Shi Antonio Abate Hsing-Lin Wang 《Nano-Micro Letters》 2026年第5期405-423,共19页
Two-step-processed(TSP)inverted p-i-n perovskite solar cells(PSCs)have demonstrated significant promise in tandem applications.However,the power conversion efficiency(PCE)of TSP p-i-n PSCs rarely exceeds 24%.Here,we d... Two-step-processed(TSP)inverted p-i-n perovskite solar cells(PSCs)have demonstrated significant promise in tandem applications.However,the power conversion efficiency(PCE)of TSP p-i-n PSCs rarely exceeds 24%.Here,we demonstrate that TSP perovskite films exhibit a vertically gradient distribution of residual PbI_(2)clusters,which form Schottky heterojunctions with the perovskite,leading to substantial interfacial energy-level mismatches within NiO_(x)-based TSP p-i-n PSCs.These limitations were effectively addressed via a vertical interfacial engineering enabled by dual-interface modification incorporating tin trifluoromethanesulfonate(Sn(OTF)_(2))and 4-Fluorophenylethylamine chloride(F-PEA)at the NiO_(x)/perovskite and perovskite/C60 interfaces,respectively.The functional Sn(OTF)_(2)not only enhances the conductivity of NiO_(x)films but also suppresses ion migration,while inducing the formation of a Pb-Sn mixed perovskite interlayer that precisely regulates the energy level at the NiO_(x)/perovskite interface.Complementally,F-PEA post-treatment effectively converts surface residual PbI_(2)clusters into a 2D perovskite capping layer,which simultaneously passivates surface defects and enhances energy-level alignment at the perovskite/C60 interface.Consequently,the optimized NiO_(x)-based TSP p-i-n PSCs achieve a notable PCE of 25.6%with superior operational stability.This study elucidates the underlying mechanisms limiting the efficiency of TSP p-i-n PSCs,while establishing design principles for these devices targeting 26%efficiency. 展开更多
关键词 Vertical interfacial engineering Interface modification Energy-level modulation Nickle oxide Two-step procession
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Microstructures and mechanical properties of friction stir welded and processed high entropy alloys
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作者 Kang Chen Jian Miao +2 位作者 Huijie Zhang Qi Cheng Yingling Wang 《Defence Technology(防务技术)》 2026年第1期80-108,共29页
High entropy alloys(HEAs)have recently attracted significant attention due to their exceptional mechanical properties and potential applications across various fields.Friction stir welding and processing(FSW/P),as not... High entropy alloys(HEAs)have recently attracted significant attention due to their exceptional mechanical properties and potential applications across various fields.Friction stir welding and processing(FSW/P),as notable solid-state welding and processing techniques,have been proved effectiveness in enhancing microstructures and mechanical properties of HEAs.This review article summarizes the current status of FSW/P of HEAs.The welding materials and conditions used for FSW/P in HEAs are reviewed and discussed.The effects of FSW/P on the evolutions of grain structure,texture,dislocation,and secondary phase for different HEAs are highlighted.Furthermore,the influences of FSW/P on the mechanical properties of various HEAs are analyzed.Finally,potential applications,challenges,and future directions of FSW/P in HEAs are forecasted.Overall,FSW/P enable to refine grains of HEAs through dynamic recrystallization and to activate diverse deformation mechanisms of HEAs through tailoring phase structures,thereby significantly improving the strength,hardness,and ductility of both single-and dual-phase HEAs.Future progress in this field will rely on comprehensive optimization of processing parameters and alloy composition,integration of multi-scale modeling with advanced characterization for in-depth exploration of microstructural mechanisms,systematic evaluation of functional properties,and effective bridging of the gap between laboratory research and industrial application.The review aims to provide an overview of recent advancements in the FSW/P of HEAs and encourage further research in this area. 展开更多
关键词 High entropy alloys Friction stir welding/processing MICROSTRUCTURE Mechanical property
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Preface to the Special Issue on Atmospheric and Oceanic Processes in the Antarctic and Their Climate Effects: 40 Years of CHINARE
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作者 Zhaomin WANG Bingyi WU +7 位作者 Wen ZHOU Jiping LIU Anmin DUAN Xianyao CHEN Ruibo LEI Minghu DING Xichen LI Wenju CAI 《Advances in Atmospheric Sciences》 2025年第12期2395-2398,共4页
In November 1984,China launched its first expedition to the Southern Ocean and the Antarctic continent,culminating in the establishment of its first year-round research station—Great Wall Station—on the Antarctic Pe... In November 1984,China launched its first expedition to the Southern Ocean and the Antarctic continent,culminating in the establishment of its first year-round research station—Great Wall Station—on the Antarctic Peninsula in February 1985.Forty years later,in February 2024,China’s fifth research station,Qinling Station,commenced operations on Inexpress-ible Island near Terra Nova Bay. 展开更多
关键词 Great Wall Station atmospheric processes oceanic processes climate effects China research stations Qinling Station ANTARCTIC
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Assembly processes of rare and abundant microbial taxa are closely related to bacterial and fungal functionality during desert vegetation reestablishment
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作者 Zhouchang YU Wei ZHANG +11 位作者 Pian DUO Ying ZHANG Xingfang TIAN Lin SUN Yuzheng GU Junhong ZHANG Jiaxing SONG Ahejiang SAILIKE Yujie LIANG Rong FU Zhiguo XIE Peizhi YANG 《Pedosphere》 2025年第3期475-489,共15页
Effective vegetation reconstruction plays a vital role in the restoration of desert ecosystems.However,in reconstruction of different vegetation types,the community characteristics,assembly processes,and functions of ... Effective vegetation reconstruction plays a vital role in the restoration of desert ecosystems.However,in reconstruction of different vegetation types,the community characteristics,assembly processes,and functions of different soil microbial taxa under environmental changes are still disputed,which limits the understanding of the sustainability of desert restoration.Hence,we investigated the soil microbial community characteristics and functional attributes of grassland desert(GD),desert steppe(DS),typical steppe(TS),and artificial forest(AF)in the Mu Us Desert,China.Our findings confirmed the geographical conservation of soil microbial composition but highlighted decreased microbial diversity in TS.Meanwhile,the abundance of rare taxa and microbial community stability in TS improved.Heterogeneous and homogeneous selection determined the assembly of rare and abundant bacterial taxa,respectively,with both being significantly influenced by soil moisture.In contrast,fungal communities displayed stochastic processes and exhibited sensitivity to soil nutrient conditions.Furthermore,our investigation revealed a noteworthy augmentation in bacterial metabolic functionality in TS,aligning with improved vegetation restoration and the assemblage of abundant bacterial taxa.However,within nutrient-limited soils(GD,DS,and AF),the assembly dynamics of rare fungal taxa assumed a prominent role in augmenting their metabolic capacity and adaptability to desert ecosystems.These results highlighted the variations in the assembly processes and metabolic functions of soil microorganisms during vegetation reestablishment and provided corresponding theoretical support for anthropogenic revegetation of desert ecosystems. 展开更多
关键词 deterministic processes metabolic function microbial community assembly rare microbial taxa REVEGETATION stochastic processes
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Ultra-processed foods and dietary habits of oncology patients:Risk factor or survival strategy
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作者 Balint Madarasz Mate Adam Balazs +5 位作者 Erzsebet Palfi Julia Konczos Andrea Toth Gyongyver Szentmartoni Zoltan Herold Magdolna Dank 《World Journal of Clinical Oncology》 2025年第12期90-99,共10页
The consumption of ultra-processed foods(UPFs)is continuously increasing,and there is growing evidence that these foods contribute to the development and progression of cancer.For oncology patients alone,maintaining n... The consumption of ultra-processed foods(UPFs)is continuously increasing,and there is growing evidence that these foods contribute to the development and progression of cancer.For oncology patients alone,maintaining nutritional status is crucial for tolerating treatments and improving survival.The aim of this paper is to review the role of UPFs in the diet of oncology patients,highlighting their potential health-damaging effects(e.g.,increased inflammation,microbiome disruption,nutrient deficiencies)and potential benefits(e.g.,easy accessibility,high energy content,specially formulated nutritional supplements)particularly in the context of addressing the energy and nutrient needs and nutritional challenges of patients experiencing cancer-related cachexia or anorexia.Using a literature review,we examine how the UPFs can impact oncology patients’health,supporting the quality of life and clinical outcomes of oncology patients. 展开更多
关键词 Ultra-processed foods Oncology patients Cancer nutrition Nutritional status Quality of life processed food and cancer
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Adsorption-Driven Interfacial Interactions: The Key to Enhanced Performance in Heterogeneous Advanced Oxidation Processes 被引量:1
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作者 Jinming Luo Deyou Yu +3 位作者 Kaixing Fu Zhuoya Fang Xiaolin Zhang Mingyang Xing 《Engineering》 2025年第4期22-25,共4页
Current research on heterogeneous advanced oxidation processes(HAOPs)predominantly emphasizes catalyst iteration and innovation.Significant efforts have been made to regulate the electron structure and optimize the el... Current research on heterogeneous advanced oxidation processes(HAOPs)predominantly emphasizes catalyst iteration and innovation.Significant efforts have been made to regulate the electron structure and optimize the electron distribution,thereby increasing the catalytic activity.However,this focus often overshadows an equally essential aspect of HAOPs:the adsorption effect.Adsorption is a critical initiator for triggering the interaction of oxidants and contaminants with heterogeneous catalysts.The efficacy of these interactions is influenced by a variety of physicochemical properties,including surface chemistry and pore sizes,which determine the affinities between contaminants and material surfaces.This dispar ity in affinity is pivotal because it underpins the selective removal of contaminants,especially in complex waste streams containing diverse contaminants and competing matrices.Consequently,understanding and mastering these interfacial interactions is fundamentally indispensable not only for improving pro cess efficiency but also for enhancing the selectivity of contaminant removal.Herein,we highlight the importance of adsorption-driven interfacial interactions for fundamentally elucidating the catalytic mechanisms of HAOPs.Such interactions dictate the overall performance of the treatment processes by balancing the adsorption,reaction,and desorption rates on the catalyst surfaces.Elucidating the adsorption effect not only shifts the paradigm in understanding HAOPs but also improves their practical ity in water treatment and wastewater decontamination.Overall,we propose that revisiting adsorption driven interfacial interactions holds great promise for optimizing catalytic processes to develop effective HAOP strategies. 展开更多
关键词 Heterogeneous advanced oxidation processeS ADSORPTION Pollutant degradation Dual active sites CATALYSIS SELECTIVITY
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Progress in study of spray pyrolysis technology for chloride salt solutions in rare earth extraction and separation processes 被引量:1
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作者 Ziyi Cheng Xiaowei Huang +5 位作者 Zongyu Feng Jianping Long Hai Yu Meng Wang Juanyu Yang Haiqing Hao 《Journal of Rare Earths》 2025年第10期2053-2064,I0001,共13页
This paper focuses on the preparation of rare earth oxide products from rare earth chloride solutions during the rare earth extraction and separation processes,as well as the recycling of magnesium chloride solutions.... This paper focuses on the preparation of rare earth oxide products from rare earth chloride solutions during the rare earth extraction and separation processes,as well as the recycling of magnesium chloride solutions.It proposes the idea of introducing spray pyrolysis technology into the rare earth extraction and separation processes.This paper briefly describes the development history of chloride spray pyrolysis technology,focusing on the research status and application progress of rare earth chloride solution and magnesium chloride solution spray pyrolysis technology,as well as spray pyrolysis equipment.The paper also analyzes the challenges and technical intricacies associated with applying spray pyrolysis technology to chloride solutions in the rare earth extraction and separation processes.Additionally,it explores future trends and proposes strategies to facilitate the full recycling of acids and bases,streamline the process flow,and enhance the prospects for green and low-carbon rare earth metallurgy. 展开更多
关键词 Rare earths Separation processes Spray pyrolysis technology Chloride salt solutions Green recycling
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Numerical calculation of bottom hole circulating temperature in wellbore cementing processes with multi-fluid and multi-step 被引量:1
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作者 Xu-Ning Wu Zheng-Meng Hou +5 位作者 Zao-Yuan Li Bo Feng Lin Wu Qian-Jun Chen Nan Cai Ting-Cong Wei 《Petroleum Science》 2025年第4期1578-1595,共18页
In oil and gas well cementing processes,accurately predicting the bottom hole circulating temperature(BHCT)is critical to ensuring effective zonal isolation.Overestimating the temperature can lead to excessive retarda... In oil and gas well cementing processes,accurately predicting the bottom hole circulating temperature(BHCT)is critical to ensuring effective zonal isolation.Overestimating the temperature can lead to excessive retardation issues,while underestimation can cause cementing accidents.Current methods for calculating the BHCT of cement slurry typically simplify the cementing processes to a single-fluid circulation and ignore the impact of pre-cementing processes on temperature,leading to significant discrepancies between calculated and actual results.In this study,the wellbore and formation are simplified into a two-dimensional axisymmetric structure,and a mathematical model of the temperature field under multi-fluid and multi-step conditions is established based on the law of energy conservation.The finite volume method was used to discretize the model,and a transient temperature field solver for the entire cementing process was developed,which can numerically calculate the temperature of any fluid at any time,any location.For an actual well example,the temperature distribution of the wellbore and formation after casing running is taken as the initial condition.Numerical calculations were performed sequentially to calculate the temperature fields of circulation flushing,wellbore preparation,and cementing,as well as the BHCT of the cement slurry.The study reveals that during the circulation flushing stage,the maximum temperature point in the wellbore is located at a distance of about 366 m above the bottom of the well.In the wellbore preparation stage,due to static heat exchange,the maximum temperature point gradually shifts to the bottom of the well.The BHCT of cement slurry changes continuously under cementing processes with multi-fluid and multi-step,making it a transient value.The BHCT of the lead slurry and tail slurry are not equal,with the maximum BHCT of the tail slurry being 2.46°C higher than that of the lead slurry.If circulation flushing and wellbore preparation are not considered,the calculated BHCT of the cement slurry will have errors of+6.8%and-1.9%.The study highlighted that considering thermal effects of all cementing stages,such as circulation flushing and wellbore preparation,in BHCT calculations can help improve prediction accuracy. 展开更多
关键词 Cementing processes Bottom hole circulating temperature Multi-fluid injection Transient temperature field
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Karst Trough Control of Solute Transport Processes at Two Karst Groundwater Flow Systems,Western Hubei,Central China 被引量:1
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作者 Yi'an Wang Ruichao Zhao +6 位作者 Lin Ding Shuai Xiong Yin Li Jianwei Bu Wei Chen Hong Zhou Wei Liu 《Journal of Earth Science》 2025年第4期1731-1741,共11页
To investigate groundwater flow and solute transport characteristics of the karst trough zone in China,tracer experiments were conducted at two adjacent typical karst groundwater flow systems(Yuquandong(YQD)and Migong... To investigate groundwater flow and solute transport characteristics of the karst trough zone in China,tracer experiments were conducted at two adjacent typical karst groundwater flow systems(Yuquandong(YQD)and Migongquan(MGQ))in Sixi valley,western Hubei,China.Highresolution continuous monitoring was utilized to obtain breakthrough curves(BTCs),which were then analyzed using the multi-dispersion model(MDM)and the two-region nonequilibrium model(2RNE)with basic parameters calculated by CXTFIT and QTRACER2.Results showed that:(1)YQD flow system had a complex infiltration matrix with overland flow,conduit flow and fracture flow,while the MGQ flow system was dominated by conduit flow with fast flow transport velocity,but also small amount of fracture flow there;(2)They were well fitted based on the MDM(R^2=0.928)and 2RNE(R^2=0.947)models,indicating that they had strong adaptability in the karst trough zone;(3)conceptual models for YQD and MGQ groundwater systems were generalized.In YQD system,the solute was transported via overland flow during intense rainfall,while some infiltrated down into fissures and conduits.In MGQ system,most were directly transported to spring outlet in the fissureconduit network. 展开更多
关键词 Central China conceptual model karst trough zone multi-dispersion model and two-region nonequilibrium model solute transport processes tracer tests solute transport groundwater flow
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Three-dimensional(3D)printing-assisted freeze-casting of processed pyritum-dopedβ-tricalcium phosphate biomimetic scaffold with angiogenesis and bone regeneration capability 被引量:1
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作者 Chenxu WEI Zongan LI +9 位作者 Xiaoyun LIANG Yuwei ZHAO Xingyu ZHU Haibing HUA Guobao CHEN Kunming QIN Zhipeng CHEN Changcan SHI Feng ZHANG Weidong LI 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 2025年第9期863-880,共18页
Bone repair remains an important target in tissue engineering,making the development of bioactive scaffolds for effective bone defect repair a critical objective.In this study,β-tricalcium phosphate(β-TCP)scaffolds ... Bone repair remains an important target in tissue engineering,making the development of bioactive scaffolds for effective bone defect repair a critical objective.In this study,β-tricalcium phosphate(β-TCP)scaffolds incorporated with processed pyritum decoction(PPD)were fabricated using three-dimensional(3D)printing-assisted freeze-casting.The produced composite scaffolds were evaluated for their mechanical strength,physicochemical properties,biocompatibility,in vitro proangiogenic activity,and in vivo efficacy in repairing rabbit femoral defects.They not only demonstrated excellent physicochemical properties,enhanced mechanical strength,and good biosafety but also significantly promoted the proliferation,migration,and aggregation of pro-angiogenic human umbilical vein endothelial cells(HUVECs).In vivo studies revealed that all scaffold groups facilitated osteogenesis at the bone defect site,with theβ-TCP scaffolds loaded with PPD markedly enhancing the expression of neurogenic locus Notch homolog protein 1(Notch1),vascular endothelial growth factor(VEGF),bone morphogenetic protein-2(BMP-2),and osteopontin(OPN).Overall,the scaffolds developed in this study exhibited strong angiogenic and osteogenic capabilities both in vitro and in vivo.The incorporation of PPD notably promoted the angiogenic-osteogenic coupling,thereby accelerating bone repair,which suggests that PPD is a promising material for bone repair and that the PPD/β-TCP scaffolds hold great potential as a bone graft alternative. 展开更多
关键词 Bone defect processed pyritum Three-dimensional(3D)printing-assisted freeze-casting ANGIOGENESIS Bone regeneration VEGF-Notch1-BMP-2-OPN coupling
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Enlightenment of geochemistry for ultra-deep petroleum accumulation:Coupling of secondary processes and filling events
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作者 Rong-Zhen Qiao Mei-Jun Li +1 位作者 Dong-Lin Zhang Hong Xiao 《Petroleum Science》 2025年第4期1465-1484,共20页
Light oil and gas reservoirs are abundant in the Ordovician marine carbonate reservoir in Shunbei Oilfield,Tarim Basin.This presents a compelling geological puzzle,as ultra-deep reservoirs undergo intense alteration a... Light oil and gas reservoirs are abundant in the Ordovician marine carbonate reservoir in Shunbei Oilfield,Tarim Basin.This presents a compelling geological puzzle,as ultra-deep reservoirs undergo intense alteration and complex petroleum accumulation processes.A comprehensive suite of geochemical analyses,including molecular components,carbon isotope composition,homogenization temperature of saline inclusions,and burial-thermal history of single wells,was conducted to elucidate the genesis of these ancient reservoirs.Three petroleum filling events have been identified in the study area:Late Caledonian,Hercynian-Indosinian,and Himalayan,through analysis of homogenization temperatures of brine inclusions and burial-thermal histories.Additionally,the oil in the study area has undergone significant alteration processes such as biodegradation,thermal alteration,mixing,evaporative fractionation,and gas invasion.This study particularly emphasizes the influential role of Himalayan gas filling-induced evaporation fractionation and gas invasion in shaping the present petroleum phase distribution.Furthermore,analysis of light hydrocarbon and diamondoid parameters indicates the oil within the study area is at a high maturity stage,with equivalent vitrinite reflectance values ranging from 1.48%to 1.99%.Additionally,the analysis of light hydrocarbons,aromatics,and thiadiamondoids indicates that TSR should occur in reservoirs near the gypsum-salt layers in the Cambrian.The existence of the Cambrian petroleum system in the study area is strongly confirmed when considering the analysis results of natural gas type(oil cracking gas),evaporative fractionation,and gas invasion.Permian local thermal anomalies notably emerge as a significant factor contributing to the destruction of biomarkers in oil.For oil not subject to transient,abnormal thermal events,biomarker reliability extends to at least 190℃.In conclusion,examining the special formation mechanisms and conditions of various secondary processes can offer valuable insights for reconstructing the history of petroleum accumulation in ultradeep reservoirs.This research provides a scientific foundation for advancing our knowledge of petroleum systems and underscores the importance of hydrocarbon geochemistry in unraveling ultra-deep,complex geological phenomena. 展开更多
关键词 Ultra-deep GEOCHEMISTRY Secondary processes Igneous intrusions Petroleum accumulation
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Short-term effects of transcranial direct current stimulation on pain sensitivity, emotional and cognitive processes in non-suicidal self-injury: a randomised controlled trial
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作者 Chang Lei Diyang Qu +4 位作者 Dennis Chong Yangyang Yi Weijian Wu Yiheng Tu Runsen Chen 《General Psychiatry》 2025年第3期176-185,共10页
Background Pain sensitivity is critical for preventing non-suicidal self-injury(NSSI)behaviours;however,individuals engaging in such behaviours often exhibit decreased pain sensitivity,which may undermine this natural... Background Pain sensitivity is critical for preventing non-suicidal self-injury(NSSI)behaviours;however,individuals engaging in such behaviours often exhibit decreased pain sensitivity,which may undermine this natural safeguard.The dorsolateral prefrontal cortex(DLPFC)is a key region involved in pain regulation,and recent approaches using transcranial direct current stimulation(tDCS)to target the DLPFC have shown potential for modulating pain processing and restoring normal pain perception for individuals engaging in NSSI behaviours.Aims This study aimed to explore the immediate and short-term effects of a single session of tDCS on pain sensitivity in individuals with NSSI,as well as its secondary effects on mood and NSSI-related factors.Methods In this randomised,double-blind,parallel,sham-controlled clinical trial,participants with a history of NSSI were randomly assigned to receive either active or sham tDCS.The intervention consisted of a single 20 min tDCS session targeting the left DLPFC.The primary outcome was pain sensitivity,measured by the pressure pain threshold(PPT)and heat pain score(HPS).Secondary and additional outcomes included NSSI urges,NSSI resistance,self-efficacy in resisting NSSI,mood-related variables and exploratory cognitive-affective processes such as rumination,self-criticism and self-perceived pain sensitivity,assessed at baseline,immediately post-intervention,and at 24 hours,1 week and 2 weeks follow-ups.Results For the primary outcomes,no significant differences between groups were observed for pain sensitivity(PPT,padj=0.812;HPS,padj=0.608).However,an exploratory sensitivity analysis treating each trial as an individual observation revealed a significant effect on HPS(padj=0.036).For the secondary and additional outcomes,although there were initial improvements in joyful feelings and reductions in negative affect at 2 weeks post-intervention,these effects did not remain significant after multiple comparison corrections.Notably,reductions in rumination were statistically significant at both 1-week and 2-week follow-ups(1 week,p_(adj)=0.040;2 weeks,p_(adj)=0.042).There were no significant effects on NSSI urges,NSSI resistance,self-efficacy in resisting NSSI or self-criticism.Conclusions A single session of tDCS over the left DLPFC did not produce significant changes in pain sensitivity in individuals with NSSI.A sensitivity analysis indicated an effect on heat pain sensitivity,possibly reflecting changes in brain activity,warranting confirmation through neuroimaging.These findings suggest that tDCS warrants further investigation for its potential to influence pain-related cognitive-affective processes in individuals with NSSI. 展开更多
关键词 Non Suicidal Self Injury MOOD Dorsolateral Prefrontal Cortex modulating pain processing Transcranial Direct Current Stimulation Cognitive processes dorsolateral prefrontal cortex dlpfc transcranial direct current stimulation tdcs
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Application of titanium-based advanced oxidation processes in pesticide-contaminated water purification:Emerging opportunities and challenges
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作者 Chu Wu Zhichao Dong +5 位作者 Jinfang Hou Jian Peng Shuangyu Wu Xiaofang Wang Xiangwei Kong Yue Jiang 《Chinese Chemical Letters》 2025年第3期16-26,共11页
Efficient and innovative nano-catalytic oxidation technologies offer a breakthrough in removing emerging contaminants(ECs)from water,surpassing the limitations of traditional methods.Environmental functional materials... Efficient and innovative nano-catalytic oxidation technologies offer a breakthrough in removing emerging contaminants(ECs)from water,surpassing the limitations of traditional methods.Environmental functional materials(EFMs),particularly high-end oxidation systems using eco-friendly nanomaterials,show promise for absorbing and degrading ECs.This literature review presents a comprehensive analysis of diverse traditional restoration techniques-biological,physical,and chemical-assessing their respective applications and limitations in pesticide-contaminated water purification.Through meticulous comparison,we unequivocally advocate for the imperative integration of environmentally benign nanomaterials,notably titanium-based variants,in forthcoming methodologies.Our in-depth exploration scrutinizes the catalytic efficacy,underlying mechanisms,and adaptability of pioneering titanium-based nanomaterials across a spectrum of environmental contexts.Additionally,strategic recommendations are furnished to surmount challenges and propel the frontiers of implementing eco-friendly nanomaterials in practical water treatment scenarios. 展开更多
关键词 Emerging contaminants ATRAZINE Titanium-based nanomaterial Advanced oxidation processes Sustainable-by-design
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Dimensionality engineering of flower-like bimetallic nanozyme with high peroxidase-activity for naked-eye and on-site detection of acrylamide in thermally processed foods
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作者 Sen Chen Feifan Liu +3 位作者 Taimei Cai Rong Wang Fangjian Ning Hailong Peng 《Nano Materials Science》 2025年第1期123-133,共11页
Acrylamide(AA)is a neurotoxin and carcinogen that formed during the thermal food processing.Conventional quantification techniques are difficult to realize on-site detection of AA.Herein,a flower-like bimetallic FeCu ... Acrylamide(AA)is a neurotoxin and carcinogen that formed during the thermal food processing.Conventional quantification techniques are difficult to realize on-site detection of AA.Herein,a flower-like bimetallic FeCu nanozyme(FeCuzyme)sensor and portable platform were developed for naked-eye and on-site detection of AA.The FeCuzyme was successfully prepared and exhibited flower-like structure with 3D catalytic centers.Fe/Cu atoms were considered as active center and ligand frameworks were used as cofactor,resulting in collaborative substrate-binding features and remarkably peroxidase-like activity.During the catalytic process,the 3,3′,5,5′-tetrame-thylbenzidine(TMB)oxidation can be quenched by glutathione(GSH),and then restored after thiolene Michael addition reaction between GSH and AA.Given the“on–off–on”effect for TMB oxidation and high PODlike activity,FeCuzyme sensor exhibited a wide linear relationship from 0.50 to 18.00μM(R^(2)=0.9987)and high sensitivity(LOD=0.2360μM)with high stability.The practical application of FeCuzyme sensor was successfully validated by HPLC method.Furthermore,a FeCuzyme portable platform was designed with smartphone/laptop,and which can be used for naked-eye and on-site quantitative determination of AA in real food samples.This research provides a way for rational design of a novel nanozyme-based sensing platform for AA detection. 展开更多
关键词 ACRYLAMIDE Glutathione Bimetallic FeCu nanozyme On-site detection Thermally processed food
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Role of Surface Processes and Mantle Plumes in the Formation of Microcontinents:Insights from Numerical Modeling and the Seychelles Microcontinent Case Study
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作者 Zhijie Jia Pietro Sternai Jianbing Peng 《Journal of Earth Science》 2025年第1期233-249,共17页
Mantle plumes and surface erosion and sediment deposition affect the modes of continental lithospheric rupturing in extensional tectonic settings,modulating the evolution of rifting margins.However,their relative cont... Mantle plumes and surface erosion and sediment deposition affect the modes of continental lithospheric rupturing in extensional tectonic settings,modulating the evolution of rifting margins.However,their relative contributions to the overall evolution of rifting margins and possible roles in the formation of microcontinent are still elusive.Here,we use coupled geodynamic and surface processes numerical modeling to assess the extent to which surface processes may determine the formation of microcontinent during lithospheric stretching in presence or absence of a mantle plume underneath.Our modeling results indicate that fast extension rates and hillslope(i.e.,diffusion)erosion promote ridge jump events and therefore the formation of microcontinents.On the contrary,efficient fluvial erosion and far-reaching sediment transport(i.e.,stream power erosion)inhibits ridge jump events and the formation of microcontinents.The ridge jump event and overall evolution in our numerical models is consistent with the shift from the Mascarene Ridge to the Carlsberg Ridge that determined the formation of the Seychelles microcontinent.We therefore speculate that hillslope erosion,rather than fluvial erosion,was predominant during the formation of the Seychelles,a possible indication of overall dry local climate conditions. 展开更多
关键词 continental rifting surface processes mantle plume seychelles microcontinent surface reactions
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Corrigendum to“Fluoride contamination in groundwater:A global review of the status,processes,challenges,and remedial measures”[Geosci.Front.15(2)(2024)101734]
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作者 E.Shaji K.V.Sarath +3 位作者 M.Santosh P.K.Krishnaprasad B.K.Arya Manisha S.Babu 《Geoscience Frontiers》 2025年第3期447-447,共1页
In the published version of our article(Shaji et al.,2024),in the last paragraph of the article,Hong Kong should be corrected to Hong Kong(China)and the repetition of Spain and Ireland in the same sentence need to be ... In the published version of our article(Shaji et al.,2024),in the last paragraph of the article,Hong Kong should be corrected to Hong Kong(China)and the repetition of Spain and Ireland in the same sentence need to be deleted.The correct sentence is as below. 展开更多
关键词 processeS correct sentence fluoride contamination remedial measures STATUS global review spain ireland CHALLENGES
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A framework of the planning of priority revegetation areas for debris flow mitigation based on microclimate processes in dry-hot watersheds
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作者 LU Yafeng ZHOU Xiaokang 《Journal of Mountain Science》 2025年第5期1723-1733,共11页
Vegetation restoration is a critical strategy for mitigating debris flow hazards by stabilizing slopes and modifying hydrological processes.Effective planning of priority restoration areas is particularly essential in... Vegetation restoration is a critical strategy for mitigating debris flow hazards by stabilizing slopes and modifying hydrological processes.Effective planning of priority restoration areas is particularly essential in dry-hot valley regions,where extreme hydrothermal conditions pose significant challenges.This study presents a novel framework that integrates microclimatic variables,such as temperature lapse rates,to enhance the spatial precision of revegetation efforts.The Reshuihe watershed in Southwest China,a representative dry-hot valley,was chosen as the study area.By analyzing hourly temperature and rainfall across an elevation gradient,a quadratic relationship between temperature lapse rates and weak rainfall events was identified,underscoring the role of microclimatic processes in influencing rainfall distribution and plant-available water.Rainfall peaks were observed when the temperature lapse rate was approximately 4.5°C/km.This relationship was incorporated into a cost-based restoration framework using the Marxan model,optimizing the spatial allocation of priority areas for revegetation.Results demonstrated that integrating microclimatic variables significantly improved the effectiveness of revegetation strategies,particularly for reducing debris flow risks.The lowest restoration costs were observed between elevations of 3200 m and 3300 m,where strong correlations between temperature lapse rates and rainfall were recorded.Priority restoration areas covered 41 km^(2),targeting zones with high debris flow risks.These findings highlight the value of incorporating microclimatic data into revegetation planning,enabling cost-effective and ecologically sustainable hazard mitigation in regions vulnerable to hydrological hazards. 展开更多
关键词 REVEGETATION Microclimate processes Temperature lapse rate Dry-hot valley Priority revegetation areas
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