Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery...Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery.We rst derive the projection formulas for a vector onto the feasible sets.The centralized circumcentered-reection method is designed to solve the convex feasibility problem.Some numerical experiments demonstrate the feasibility and e ectiveness of the proposed algorithm,showing superior performance compared to conventional alternating projection methods.展开更多
During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive...During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive distance)to a moving target as quickly as possible,resulting in the extended minimum-time intercept problem(EMTIP).Existing research has primarily focused on the zero-distance intercept problem,MTIP,establishing the necessary or sufficient conditions for MTIP optimality,and utilizing analytic algorithms,such as root-finding algorithms,to calculate the optimal solutions.However,these approaches depend heavily on the properties of the analytic algorithm,making them inapplicable when problem settings change,such as in the case of a positive effective range or complicated target motions outside uniform rectilinear motion.In this study,an approach employing a high-accuracy and quality-guaranteed mixed-integer piecewise-linear program(QG-PWL)is proposed for the EMTIP.This program can accommodate different effective interception ranges and complicated target motions(variable velocity or complicated trajectories).The high accuracy and quality guarantees of QG-PWL originate from elegant strategies such as piecewise linearization and other developed operation strategies.The approximate error in the intercept path length is proved to be bounded to h^(2)/(4√2),where h is the piecewise length.展开更多
目的:探讨在骨髓增生异常综合征(MDS)中TP53基因不同突变状态(野生型/突变型)对地西他滨(DAC)耐药性的影响,并筛选耐药相关调控基因。方法:选用2种TP53状态差异的MDS细胞:M-07e:野生型;SKM-1:突变型,用递增浓度(0、0.5、1、5和10μmol/L...目的:探讨在骨髓增生异常综合征(MDS)中TP53基因不同突变状态(野生型/突变型)对地西他滨(DAC)耐药性的影响,并筛选耐药相关调控基因。方法:选用2种TP53状态差异的MDS细胞:M-07e:野生型;SKM-1:突变型,用递增浓度(0、0.5、1、5和10μmol/L)的地西他滨干预0-72 h后,采用CCK-8法检测细胞活力。通过RNA-Seq转录组测序和甲基化组学分析,筛选与耐药相关的关键基因。结果:CCK-8实验结果显示DAC对M-07e和SKM-1细胞活力的抑制作用呈时间和剂量依赖性(SKM-1耐药性最强,IC_(50)=5μmol/L vs M-07e IC_(50)=0.5μmol/L,P<0.01)。基因表达分析结果显示,M-07e细胞经DAC处理后共鉴定到662个上调基因和452个下调基因;SKM-1细胞经DAC处理后共发现515个上调基因和73个下调基因。蛋白质组学检测显示:DAC处理的M-07e细胞中共鉴定117个上调蛋白和136个下调蛋白;DAC处理的SKM-1细胞中发现91个上调蛋白和46个下调蛋白。通过整合分析上调基因和蛋白表达谱,共筛选出181个候选基因。甲基化组学分析发现884个低甲基化基因中存在高敏感位点和高CpG密度区域,其中与上述181个候选基因存在交集的共31个基因,GO功能富集分析表明这31个基因主要参与细胞分化正调控、结合过程负调控以及细胞组分组织负调控等生物学过程。结论:TP53突变通过表观遗传重编程介导DAC耐药,靶向这些基因可能改善TP53突变型MDS的预后。展开更多
The problem of designing a feedback controller to achieve asymptotic disturbance rejection / attenuation while maintaining good transient response in the RTAC system is known as a benchmark nonlinear control problem, ...The problem of designing a feedback controller to achieve asymptotic disturbance rejection / attenuation while maintaining good transient response in the RTAC system is known as a benchmark nonlinear control problem, which has been an intensive research subject since 1995. In this paper, we will further investigate the solvability of the robust disturbance rejection problem of the RTAC system by the measurement output feedback control based on the robust output regulation method. We have obtained a design by overcoming two major obstacles: find a closed-form solution of the regulator equations; and devise a nonlinear internal model to account for non-polynomial nonlinearities.展开更多
AIM To analyze the viability of Ecological Momentary Assessment(EMA) for measuring the mental states associated with psychopathological problems in adolescents.METHODS In a sample of 110 adolescents,a sociodemographic...AIM To analyze the viability of Ecological Momentary Assessment(EMA) for measuring the mental states associated with psychopathological problems in adolescents.METHODS In a sample of 110 adolescents,a sociodemographic data survey and an EMA Smartphone application over a oneweek period(five times each day),was developed to explore symptom profiles,everyday problems,coping strategies,and the contexts in which the events take place.RESULTS The positive response was 68.6%.Over 2250 prompts about mental states were recorded.In 53% of situations the smartphone was answered at home,25.5% of casesthey were with their parents or with peers(20.3%).Associations were found with attention,affective and anxiety problems(P < 0.001) in the participants who took longer to respond to the EMA app.Anxious and depressive states were highly interrelated(rho = 0.51,P < 0.001),as well as oppositional defiant problems and conduct problems(rho = 0.56,P < 0.001).Only in 6.2% of the situations the subjects perceived they had problems,mainly associated with inter-relational aspects with family,peers,boyfriends or girlfriends(31.2%).We also found moderate-high reliability on scales of satisfaction level on the context,on positive emotionality,and on the discomfort index associated with mental health problems.CONCLUSION EMA methodology using smartphones is a useful tool for understanding adolescents' daily dynamics.It achieved moderate-high reliability and accurately identified psychopathological manifestations experienced by community adolescents in their natural context.展开更多
基金Supported by the Natural Science Foundation of Guangxi Province(Grant Nos.2023GXNSFAA026067,2024GXN SFAA010521)the National Natural Science Foundation of China(Nos.12361079,12201149,12261026).
文摘Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery.We rst derive the projection formulas for a vector onto the feasible sets.The centralized circumcentered-reection method is designed to solve the convex feasibility problem.Some numerical experiments demonstrate the feasibility and e ectiveness of the proposed algorithm,showing superior performance compared to conventional alternating projection methods.
基金supported by the National Natural Sci‐ence Foundation of China(Grant No.62306325)。
文摘During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive distance)to a moving target as quickly as possible,resulting in the extended minimum-time intercept problem(EMTIP).Existing research has primarily focused on the zero-distance intercept problem,MTIP,establishing the necessary or sufficient conditions for MTIP optimality,and utilizing analytic algorithms,such as root-finding algorithms,to calculate the optimal solutions.However,these approaches depend heavily on the properties of the analytic algorithm,making them inapplicable when problem settings change,such as in the case of a positive effective range or complicated target motions outside uniform rectilinear motion.In this study,an approach employing a high-accuracy and quality-guaranteed mixed-integer piecewise-linear program(QG-PWL)is proposed for the EMTIP.This program can accommodate different effective interception ranges and complicated target motions(variable velocity or complicated trajectories).The high accuracy and quality guarantees of QG-PWL originate from elegant strategies such as piecewise linearization and other developed operation strategies.The approximate error in the intercept path length is proved to be bounded to h^(2)/(4√2),where h is the piecewise length.
文摘目的:探讨在骨髓增生异常综合征(MDS)中TP53基因不同突变状态(野生型/突变型)对地西他滨(DAC)耐药性的影响,并筛选耐药相关调控基因。方法:选用2种TP53状态差异的MDS细胞:M-07e:野生型;SKM-1:突变型,用递增浓度(0、0.5、1、5和10μmol/L)的地西他滨干预0-72 h后,采用CCK-8法检测细胞活力。通过RNA-Seq转录组测序和甲基化组学分析,筛选与耐药相关的关键基因。结果:CCK-8实验结果显示DAC对M-07e和SKM-1细胞活力的抑制作用呈时间和剂量依赖性(SKM-1耐药性最强,IC_(50)=5μmol/L vs M-07e IC_(50)=0.5μmol/L,P<0.01)。基因表达分析结果显示,M-07e细胞经DAC处理后共鉴定到662个上调基因和452个下调基因;SKM-1细胞经DAC处理后共发现515个上调基因和73个下调基因。蛋白质组学检测显示:DAC处理的M-07e细胞中共鉴定117个上调蛋白和136个下调蛋白;DAC处理的SKM-1细胞中发现91个上调蛋白和46个下调蛋白。通过整合分析上调基因和蛋白表达谱,共筛选出181个候选基因。甲基化组学分析发现884个低甲基化基因中存在高敏感位点和高CpG密度区域,其中与上述181个候选基因存在交集的共31个基因,GO功能富集分析表明这31个基因主要参与细胞分化正调控、结合过程负调控以及细胞组分组织负调控等生物学过程。结论:TP53突变通过表观遗传重编程介导DAC耐药,靶向这些基因可能改善TP53突变型MDS的预后。
基金This work was supported by the Hong Kong Research Grants Council(No.CUHK4316/02E)the National Natural Science Foundations of China(No.60374038)
文摘The problem of designing a feedback controller to achieve asymptotic disturbance rejection / attenuation while maintaining good transient response in the RTAC system is known as a benchmark nonlinear control problem, which has been an intensive research subject since 1995. In this paper, we will further investigate the solvability of the robust disturbance rejection problem of the RTAC system by the measurement output feedback control based on the robust output regulation method. We have obtained a design by overcoming two major obstacles: find a closed-form solution of the regulator equations; and devise a nonlinear internal model to account for non-polynomial nonlinearities.
基金Supported by Spain’s Ministry of Economy and Competitiveness,No.PSI 2013-46392-Pthe Agency for the Management of University and Research Grants from the Government of Catalonia,No.2014SGR1139
文摘AIM To analyze the viability of Ecological Momentary Assessment(EMA) for measuring the mental states associated with psychopathological problems in adolescents.METHODS In a sample of 110 adolescents,a sociodemographic data survey and an EMA Smartphone application over a oneweek period(five times each day),was developed to explore symptom profiles,everyday problems,coping strategies,and the contexts in which the events take place.RESULTS The positive response was 68.6%.Over 2250 prompts about mental states were recorded.In 53% of situations the smartphone was answered at home,25.5% of casesthey were with their parents or with peers(20.3%).Associations were found with attention,affective and anxiety problems(P < 0.001) in the participants who took longer to respond to the EMA app.Anxious and depressive states were highly interrelated(rho = 0.51,P < 0.001),as well as oppositional defiant problems and conduct problems(rho = 0.56,P < 0.001).Only in 6.2% of the situations the subjects perceived they had problems,mainly associated with inter-relational aspects with family,peers,boyfriends or girlfriends(31.2%).We also found moderate-high reliability on scales of satisfaction level on the context,on positive emotionality,and on the discomfort index associated with mental health problems.CONCLUSION EMA methodology using smartphones is a useful tool for understanding adolescents' daily dynamics.It achieved moderate-high reliability and accurately identified psychopathological manifestations experienced by community adolescents in their natural context.
