The airplane refueling problem can be stated as follows.We are given n airplanes which can refuel one another during the flight.Each airplane has a reservoir volume wj(liters)and a consumption rate pj(liters per kilom...The airplane refueling problem can be stated as follows.We are given n airplanes which can refuel one another during the flight.Each airplane has a reservoir volume wj(liters)and a consumption rate pj(liters per kilometer).As soon as one airplane runs out of fuel,it is dropping out of the flight.The problem asks for finding a refueling scheme such that the last plane in the air reach a maximal distance.An equivalent version is the n-vehicle exploration problem.The computational complexity of this non-linear combinatorial optimization problem is open so far.This paper employs the neighborhood exchange method of single-machine scheduling to study the precedence relations of jobs,so as to improve the necessary and sufficiency conditions of optimal solutions,and establish an efficient heuristic algorithm which is a generalization of several existing special algorithms.展开更多
In recent years,to better address soil erosion,the Loess Plateau area has seen a surge in the construction of warping dam projects.Warping dams have strong functions in soil and water conservation as well as warping f...In recent years,to better address soil erosion,the Loess Plateau area has seen a surge in the construction of warping dam projects.Warping dams have strong functions in soil and water conservation as well as warping for farmland creation,serving as a key support for ecological restoration and economic development in the Loess Plateau area in the new era.However,in light of practical conditions,there are many problems in their construction process,which have affected their actual operation quality.In this regard,while expounding on the value and significance of warping dam project construction in the Loess Plateau area,this paper discusses the existing problems and effective countermeasures,aiming to provide some references for relevant personnel.展开更多
Let K_(j)/Q,1≤j≤ν,ν≥2 be quadratic fields with pairwise coprime discriminants Dj,and let τ_(kj)^(K_(j))(n)be the divisor function associated to Dedekind zeta function SK_(j)(s).In this paper,we consider a multid...Let K_(j)/Q,1≤j≤ν,ν≥2 be quadratic fields with pairwise coprime discriminants Dj,and let τ_(kj)^(K_(j))(n)be the divisor function associated to Dedekind zeta function SK_(j)(s).In this paper,we consider a multidimensional general divisor problem related to the τ_(kj)^(K_(j))(n)involving several number fields over square integers,by establishing the corresponding asymptotic formula.As an application,we also obtain the asymptotic formula of variance of these coefi icients.展开更多
This paper is concerned with a class of nonlinear fractional differential equations with a disturbance parameter in the integral boundary conditions on the infinite interval.By using Guo-Krasnoselskii fixed point theo...This paper is concerned with a class of nonlinear fractional differential equations with a disturbance parameter in the integral boundary conditions on the infinite interval.By using Guo-Krasnoselskii fixed point theorem,fixed point index theory and the analytic technique,we give the bifurcation point of the parameter which divides the range of parameter for the existence of at least two,one and no positive solutions for the problem.And,by using a fixed point theorem of generalized concave operator and cone theory,we establish the maximum parameter interval for the existence of the unique positive solution for the problem and show that such a positive solution continuously depends on the parameter.In the end,some examples are given to illustrate our main results.展开更多
In a world where supply chains are increasingly complex and unpredictable,finding the optimal way to move goods through transshipment networks is more important and challenging than ever.In addition to addressing the ...In a world where supply chains are increasingly complex and unpredictable,finding the optimal way to move goods through transshipment networks is more important and challenging than ever.In addition to addressing the complexity of transportation costs and demand,this study presents a novel method that offers flexible routing alternatives to manage these complexities.When real-world variables such as fluctuating costs,variable capacity,and unpredictable demand are considered,traditional transshipment models often prove inadequate.To overcome these challenges,we propose an innovative fully fuzzy-based framework using LR flat fuzzy numbers.This framework allows for more adaptable and flexible decision-making in multi-objective transshipment situations by effectively capturing uncertain parameters.To overcome these challenges,we develop an innovative,fully fuzzy-based framework using LR flat fuzzy numbers to effectively capture uncertainty in key parameters,offering more flexible and adaptive decision-making in multi-objective transshipment problems.The proposed model also presents alternative route options,giving decisionmakers a range of choices to satisfy multiple requirements,including reducing costs,improving service quality,and expediting delivery.Through extensive numerical experiments,we demonstrate that the model can achieve greater adaptability,efficiency,and flexibility than standard approaches.This multi-path structure provides additional flexibility to adapt to dynamic network conditions.Using ranking strategies,we compared our multi-objective transshipment model with existing methods.The results indicate that,while traditional methods such as goal and fuzzy programming generate results close to the anti-ideal value,thus reducing their efficiency,our model produces solutions close to the ideal value,thereby facilitating better decision making.By combining dynamic routing alternatives with a fully fuzzybased approach,this study offers an effective tool to improve decision-making and optimize complex networks under real-world conditions in practical settings.In this paper,we utilize LINGO 18 software to solve the provided numerical example,demonstrating the effectiveness of the proposed method.展开更多
With the development of technology,diffusion model-based solvers have shown significant promise in solving Combinatorial Optimization(CO)problems,particularly in tackling Non-deterministic Polynomial-time hard(NP-hard...With the development of technology,diffusion model-based solvers have shown significant promise in solving Combinatorial Optimization(CO)problems,particularly in tackling Non-deterministic Polynomial-time hard(NP-hard)problems such as the Traveling Salesman Problem(TSP).However,existing diffusion model-based solvers typically employ a fixed,uniform noise schedule(e.g.,linear or cosine annealing)across all training instances,failing to fully account for the unique characteristics of each problem instance.To address this challenge,we present GraphGuided Diffusion Solvers(GGDS),an enhanced method for improving graph-based diffusion models.GGDS leverages Graph Neural Networks(GNNs)to capture graph structural information embedded in node coordinates and adjacency matrices,dynamically adjusting the noise levels in the diffusion model.This study investigates the TSP by examining two distinct time-step noise generation strategies:cosine annealing and a Neural Network(NN)-based approach.We evaluate their performance across different problem scales,particularly after integrating graph structural information.Experimental results indicate that GGDS outperforms previous methods with average performance improvements of 18.7%,6.3%,and 88.7%on TSP-500,TSP-100,and TSP-50,respectively.Specifically,GGDS demonstrates superior performance on TSP-500 and TSP-50,while its performance on TSP-100 is either comparable to or slightly better than that of previous methods,depending on the chosen noise schedule and decoding strategy.展开更多
This study examines the mediating role of positive psychological capital and the moderating role of ethnicity in the relationship between mindfulness and internalizing/externalizing problems among adolescents.The stud...This study examines the mediating role of positive psychological capital and the moderating role of ethnicity in the relationship between mindfulness and internalizing/externalizing problems among adolescents.The study sample comprized Chinese adolescents(N=637 ethnic minority;females=40.97%,meam age=12.68,SD=0.49 years;N=636 Han;females=49.06%,mean age=12.71,SD=0.47 years).The participants completed the Child and Adolescent Mindfulness Measure,the Positive Psycap Questionnaire,and the Youth Self-Report.Results from the moderated mediation analysis showed mindfulness was negatively associated with both internalizing and externalizing problems.Ethnicity moderated the relationship between mindfulness and internalizing problems to be stronger for Han adolescents compared to ethnic minority adolescents.Psychological capital mediated the relationship between mindfulness and internalizing problems in both groups,with a negative direction.Findings support the Conservation of Resources theory and highlight mindfulness as a personal resource fostering adolescent well-being in multicultural contexts.展开更多
Objectives:Ribosomal protein S6 kinase A2(RPS6KA2)has been identified as a potential prognostic biomarker in several cancers,including breast cancer,glioblastoma,and prostate cancer.However,its functional significance...Objectives:Ribosomal protein S6 kinase A2(RPS6KA2)has been identified as a potential prognostic biomarker in several cancers,including breast cancer,glioblastoma,and prostate cancer.However,its functional significance in ovarian cancer is not well characterized.This study was designed to explore the therapeutic relevance of modulating RPS6KA2 in the context of ovarian cancer,particularly in relation to cisplatin resistance.Methods:The expression levels of RPS6KA2 and key regulators involved in autophagy and ferroptosis were assessed using quantitative reverse transcription-PCR,immunofluorescence staining,immunohistochemistry,and western blotting.Prognostic associations were conducted using the Kaplan-Meier Plotter database.Autophagy flux assays and visualization of autophagosomes were performed to assess autophagy activity.Ferroptosis-related parameters,including intracellular iron content,glutathione(GSH)levels,reactive oxygen species(ROS)generation,and mitochondrial membrane potential,were measured to determine ferroptotic changes.In vivo experiments were carried out to determine the antitumor efficacy of RPS6KA2 modulation in combination with pathway-specific agents.Results:Using ovarian cancer cell lines and clinical tissue samples,we demonstrated that RPS6KA2 expression was significantly downregulated in cisplatin-resistant cells and tissues compared to their sensitive counterparts.Low RPS6KA2 expression correlated with unfavorable patient outcomes and enhanced chemoresistance.Mechanistically,RPS6KA2 inhibited autophagy by modulating the phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin(PI3K-AKT-mTOR)signaling pathway,which in turn increased sensitivity to cisplatin.Additionally,RPS6KA2 facilitated ferroptosis,contributing to its tumor-suppressive function.miR-512-3p was identified as a negative regulator of RPS6KA2,driving cisplatin resistance through suppression of RPS6KA2 expression.In vivo validation confirmed that combining RPS6KA2 targeting with autophagy inhibitors or ferroptosis inducers significantly enhanced cisplatin sensitivity in ovarian cancer models.Conclusion:These results collectively indicate that targeting the miR-512-3p/RPS6KA2 regulatory axis may offer a novel and effective strategy for overcoming cisplatin resistance in ovarian cancer.展开更多
This paper is concerned with the following nonlinear Steklov problemΔu=0 in D,∂vu=λf(u)on∂D,where D is the unit disk in the plane,∂v denotes the unit outward normal derivative.For each k∈N,under some natural condit...This paper is concerned with the following nonlinear Steklov problemΔu=0 in D,∂vu=λf(u)on∂D,where D is the unit disk in the plane,∂v denotes the unit outward normal derivative.For each k∈N,under some natural conditions on f,using the Crandall-Rabinowitz bifurcation theorem,we obtain a bifurcation curve emanating from(k,0).Furthermore,we also analyze the local structure of bifurcation curves and stability of solutions on them.Specifically,our results indicate the bifurcation is critical for each k and is subcritical(supercritical)if f'''(0)>0(f'''(0)<0).展开更多
Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functi...Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome(BAC)clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated.This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC,outlining their genomic origins,molecular mechanisms,and biological significance.We highlight their roles in metabolic reprogramming,microRNA network modulation,and tumor progression,as well as their diagnostic and prognostic value in tissue and serum-based analyses.Finally,we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy.展开更多
In educational settings,instructors often lead students through hands-on software projects,sometimes engaging two different schools or departments.How can such collaborations be made more efficient,and how can student...In educational settings,instructors often lead students through hands-on software projects,sometimes engaging two different schools or departments.How can such collaborations be made more efficient,and how can students truly experience the importance of teamwork and the impact of organizational structure on project complexity?To answer these questions,we introduce the requirement-driven organization structure(R-DOS)approach,which tightly couples software requirements with the actual development process.By extending problem-frames modeling and focusing on requirements,R-DOS allows educators and students to(1)diagnose structural flaws early,(2)prescribe role-level and communication fixes,and(3)observe-in real time-how poor structure can derail a project while good structure accelerates learning and delivery.展开更多
Generalised reduced masses with a set of equations governing the three relative motions between two of 3-bodies in their gravitational field are established,of which the dynamic characteristics of 3-body dynamics,fund...Generalised reduced masses with a set of equations governing the three relative motions between two of 3-bodies in their gravitational field are established,of which the dynamic characteristics of 3-body dynamics,fundamental bases of this paper,are revealed.Based on these findings,an equivalent system is developed,which is a 2-body system with its total mass,constant angular momentum,kinetic and potential energies same as the total ones of three relative motions,so that it can be solved using the well-known theory of the 2-body system.From the solution of an equivalent system with the revealed characteristics of three relative motions,the general theoretical solutions of the 3-body system are obtained in the curve-integration forms along the orbits in the imaged radial motion space.The possible periodical orbits with generalised Kepler’s law are presented.Following the description and mathematical demonstrations of the proposed methods,the examples including Euler’s/Lagrange’s problems,and a reported numerical one are solved to validate the proposed methods.The methods derived from the 3-body system are extended to N-body problems.展开更多
Sensitivity of observational data is important in the study of Glacial Isostatic Adjustment(GIA).However,depending on whether sensitivity is used for the Inverse Problem or the Forward Problem,the final formulation an...Sensitivity of observational data is important in the study of Glacial Isostatic Adjustment(GIA).However,depending on whether sensitivity is used for the Inverse Problem or the Forward Problem,the final formulation and display of the sensitivity kernel will be different.Unfortunately,in the past,both perspectives give the same name to their quantity computed/displayed,and that has caused some confusion.To distinguish between the two,their perspective should be added to the names.This paper focuses only on the perspective of the Forward Problem where the input parameters are known.The Perturbation method has been successfully used in the computation of the sensitivity kernels of observations on 1D and 3D viscosity variations from the Forward perspective.One aim of this paper is to review and clarify the physics of the Perturbation method and bring out some important aspects of this method that have been misunderstood or neglected.Another aim is to present sensitivity kernels from the Perturbation method using 3D(both radially and laterally heterogeneous)Earth models with realistic ice history.These new results are now suitable for future comparison with those from new methods using the Forward perspective.Finally,the sensitivity computations for realistic ice histories on a 3D Earth is reviewed and used to search for optimal locations of new GIA observations.展开更多
基金Supported by Natural Science Foundation of Henan Province(Grant Nos.232300421218 and 252300421483).
文摘The airplane refueling problem can be stated as follows.We are given n airplanes which can refuel one another during the flight.Each airplane has a reservoir volume wj(liters)and a consumption rate pj(liters per kilometer).As soon as one airplane runs out of fuel,it is dropping out of the flight.The problem asks for finding a refueling scheme such that the last plane in the air reach a maximal distance.An equivalent version is the n-vehicle exploration problem.The computational complexity of this non-linear combinatorial optimization problem is open so far.This paper employs the neighborhood exchange method of single-machine scheduling to study the precedence relations of jobs,so as to improve the necessary and sufficiency conditions of optimal solutions,and establish an efficient heuristic algorithm which is a generalization of several existing special algorithms.
文摘In recent years,to better address soil erosion,the Loess Plateau area has seen a surge in the construction of warping dam projects.Warping dams have strong functions in soil and water conservation as well as warping for farmland creation,serving as a key support for ecological restoration and economic development in the Loess Plateau area in the new era.However,in light of practical conditions,there are many problems in their construction process,which have affected their actual operation quality.In this regard,while expounding on the value and significance of warping dam project construction in the Loess Plateau area,this paper discusses the existing problems and effective countermeasures,aiming to provide some references for relevant personnel.
基金Supported in part by NSFC(Nos.12401011,12201214)National Key Research and Development Program of China(No.2021YFA1000700)+3 种基金Shaanxi Fundamental Science Research Project for Mathematics and Physics(No.23JSQ053)Science and Technology Program for Youth New Star of Shaanxi Province(No.2025ZC-KJXX-29)Natural Science Basic Research Program of Shaanxi Province(No.2025JC-YBQN-091)Scientific Research Foundation for Young Talents of WNU(No.2024XJ-QNRC-01)。
文摘Let K_(j)/Q,1≤j≤ν,ν≥2 be quadratic fields with pairwise coprime discriminants Dj,and let τ_(kj)^(K_(j))(n)be the divisor function associated to Dedekind zeta function SK_(j)(s).In this paper,we consider a multidimensional general divisor problem related to the τ_(kj)^(K_(j))(n)involving several number fields over square integers,by establishing the corresponding asymptotic formula.As an application,we also obtain the asymptotic formula of variance of these coefi icients.
基金Supported by the National Natural Science Foundation of China(11361047)Fundamental Research Program of Shanxi Province(20210302124529)。
文摘This paper is concerned with a class of nonlinear fractional differential equations with a disturbance parameter in the integral boundary conditions on the infinite interval.By using Guo-Krasnoselskii fixed point theorem,fixed point index theory and the analytic technique,we give the bifurcation point of the parameter which divides the range of parameter for the existence of at least two,one and no positive solutions for the problem.And,by using a fixed point theorem of generalized concave operator and cone theory,we establish the maximum parameter interval for the existence of the unique positive solution for the problem and show that such a positive solution continuously depends on the parameter.In the end,some examples are given to illustrate our main results.
基金the financial support of the European Union under the REFRESH-Research Excellence for Region Sustainability and High-tech Industries project number CZ.10.03.01/00/22_003/0000048 via the Operational Programme Just Transition and has been done in connection with project Students Grant Competition SP2025/062"specific research on progressive and sustainable production technologies"and SP2025/063"specific research on innovative and progressive manufacturing technologies"financed by the Ministry of Education,Youth and Sports and Faculty of Mechanical Engineering VSB-TUOThe authors would like to extend their sincere appreciation to Researchers Supporting Project number(RSP2025R472)King Saud University,Riyadh,Saudi Arabia.
文摘In a world where supply chains are increasingly complex and unpredictable,finding the optimal way to move goods through transshipment networks is more important and challenging than ever.In addition to addressing the complexity of transportation costs and demand,this study presents a novel method that offers flexible routing alternatives to manage these complexities.When real-world variables such as fluctuating costs,variable capacity,and unpredictable demand are considered,traditional transshipment models often prove inadequate.To overcome these challenges,we propose an innovative fully fuzzy-based framework using LR flat fuzzy numbers.This framework allows for more adaptable and flexible decision-making in multi-objective transshipment situations by effectively capturing uncertain parameters.To overcome these challenges,we develop an innovative,fully fuzzy-based framework using LR flat fuzzy numbers to effectively capture uncertainty in key parameters,offering more flexible and adaptive decision-making in multi-objective transshipment problems.The proposed model also presents alternative route options,giving decisionmakers a range of choices to satisfy multiple requirements,including reducing costs,improving service quality,and expediting delivery.Through extensive numerical experiments,we demonstrate that the model can achieve greater adaptability,efficiency,and flexibility than standard approaches.This multi-path structure provides additional flexibility to adapt to dynamic network conditions.Using ranking strategies,we compared our multi-objective transshipment model with existing methods.The results indicate that,while traditional methods such as goal and fuzzy programming generate results close to the anti-ideal value,thus reducing their efficiency,our model produces solutions close to the ideal value,thereby facilitating better decision making.By combining dynamic routing alternatives with a fully fuzzybased approach,this study offers an effective tool to improve decision-making and optimize complex networks under real-world conditions in practical settings.In this paper,we utilize LINGO 18 software to solve the provided numerical example,demonstrating the effectiveness of the proposed method.
基金supported by the National Science and Technology Council,Taiwan,under grant no.NSTC 114-2221-E-197-005-MY3.
文摘With the development of technology,diffusion model-based solvers have shown significant promise in solving Combinatorial Optimization(CO)problems,particularly in tackling Non-deterministic Polynomial-time hard(NP-hard)problems such as the Traveling Salesman Problem(TSP).However,existing diffusion model-based solvers typically employ a fixed,uniform noise schedule(e.g.,linear or cosine annealing)across all training instances,failing to fully account for the unique characteristics of each problem instance.To address this challenge,we present GraphGuided Diffusion Solvers(GGDS),an enhanced method for improving graph-based diffusion models.GGDS leverages Graph Neural Networks(GNNs)to capture graph structural information embedded in node coordinates and adjacency matrices,dynamically adjusting the noise levels in the diffusion model.This study investigates the TSP by examining two distinct time-step noise generation strategies:cosine annealing and a Neural Network(NN)-based approach.We evaluate their performance across different problem scales,particularly after integrating graph structural information.Experimental results indicate that GGDS outperforms previous methods with average performance improvements of 18.7%,6.3%,and 88.7%on TSP-500,TSP-100,and TSP-50,respectively.Specifically,GGDS demonstrates superior performance on TSP-500 and TSP-50,while its performance on TSP-100 is either comparable to or slightly better than that of previous methods,depending on the chosen noise schedule and decoding strategy.
基金supported by the Guizhou Provincial Science and Technology Projects[Basic Science of Guizhou-[2024]Youth 309,Guizhou Platform Talents[2021]1350-046]Zunyi Science and Technology Cooperation[HZ(2024)311]+3 种基金Funding of the Chinese Academy of Social Sciences(2024SYZH005)Peking University Longitudinal Scientific Research Technical Service Project(G-252)Guizhou Provincial Graduate Student Research Fund Project(2024YJSKYJJ339)Zunyi Medical University Graduate Research Fund Project(ZYK206).
文摘This study examines the mediating role of positive psychological capital and the moderating role of ethnicity in the relationship between mindfulness and internalizing/externalizing problems among adolescents.The study sample comprized Chinese adolescents(N=637 ethnic minority;females=40.97%,meam age=12.68,SD=0.49 years;N=636 Han;females=49.06%,mean age=12.71,SD=0.47 years).The participants completed the Child and Adolescent Mindfulness Measure,the Positive Psycap Questionnaire,and the Youth Self-Report.Results from the moderated mediation analysis showed mindfulness was negatively associated with both internalizing and externalizing problems.Ethnicity moderated the relationship between mindfulness and internalizing problems to be stronger for Han adolescents compared to ethnic minority adolescents.Psychological capital mediated the relationship between mindfulness and internalizing problems in both groups,with a negative direction.Findings support the Conservation of Resources theory and highlight mindfulness as a personal resource fostering adolescent well-being in multicultural contexts.
基金supported by the Academic Leader Training Programof Pudong New Area Health System in Shanghai(Grant No.PWRd2021-13)Shanghai Municipal Health Commission(Grant No.202340094).
文摘Objectives:Ribosomal protein S6 kinase A2(RPS6KA2)has been identified as a potential prognostic biomarker in several cancers,including breast cancer,glioblastoma,and prostate cancer.However,its functional significance in ovarian cancer is not well characterized.This study was designed to explore the therapeutic relevance of modulating RPS6KA2 in the context of ovarian cancer,particularly in relation to cisplatin resistance.Methods:The expression levels of RPS6KA2 and key regulators involved in autophagy and ferroptosis were assessed using quantitative reverse transcription-PCR,immunofluorescence staining,immunohistochemistry,and western blotting.Prognostic associations were conducted using the Kaplan-Meier Plotter database.Autophagy flux assays and visualization of autophagosomes were performed to assess autophagy activity.Ferroptosis-related parameters,including intracellular iron content,glutathione(GSH)levels,reactive oxygen species(ROS)generation,and mitochondrial membrane potential,were measured to determine ferroptotic changes.In vivo experiments were carried out to determine the antitumor efficacy of RPS6KA2 modulation in combination with pathway-specific agents.Results:Using ovarian cancer cell lines and clinical tissue samples,we demonstrated that RPS6KA2 expression was significantly downregulated in cisplatin-resistant cells and tissues compared to their sensitive counterparts.Low RPS6KA2 expression correlated with unfavorable patient outcomes and enhanced chemoresistance.Mechanistically,RPS6KA2 inhibited autophagy by modulating the phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin(PI3K-AKT-mTOR)signaling pathway,which in turn increased sensitivity to cisplatin.Additionally,RPS6KA2 facilitated ferroptosis,contributing to its tumor-suppressive function.miR-512-3p was identified as a negative regulator of RPS6KA2,driving cisplatin resistance through suppression of RPS6KA2 expression.In vivo validation confirmed that combining RPS6KA2 targeting with autophagy inhibitors or ferroptosis inducers significantly enhanced cisplatin sensitivity in ovarian cancer models.Conclusion:These results collectively indicate that targeting the miR-512-3p/RPS6KA2 regulatory axis may offer a novel and effective strategy for overcoming cisplatin resistance in ovarian cancer.
基金supported by the National Natural Science Foundation of China(No.32060165)the Guizhou Provincial Science and Technology Department Project(qian ke he jichu-ZK[2021]zhongdian 031).
基金Supported by the National Natural Science Foundation of China(Grant No.12371110).
文摘This paper is concerned with the following nonlinear Steklov problemΔu=0 in D,∂vu=λf(u)on∂D,where D is the unit disk in the plane,∂v denotes the unit outward normal derivative.For each k∈N,under some natural conditions on f,using the Crandall-Rabinowitz bifurcation theorem,we obtain a bifurcation curve emanating from(k,0).Furthermore,we also analyze the local structure of bifurcation curves and stability of solutions on them.Specifically,our results indicate the bifurcation is critical for each k and is subcritical(supercritical)if f'''(0)>0(f'''(0)<0).
基金supported by the National Research Foundation of Korea(NRF),funded by the Ministry of Science and ICT(MSIT),Republic of Korea(grant numbers:RS-2022-NR070489 and RS-2023-00210847)the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health and Welfare,Republic of Korea(grant number HR21C1003).
文摘Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome(BAC)clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated.This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC,outlining their genomic origins,molecular mechanisms,and biological significance.We highlight their roles in metabolic reprogramming,microRNA network modulation,and tumor progression,as well as their diagnostic and prognostic value in tissue and serum-based analyses.Finally,we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy.
基金supported by the National Natural Science Foundation of China(No.62362006)Guangxi Science and Technology Project(Key Research&Development)(No.GuiKeAB24010343)+1 种基金Guangxi“Bagui Scholar”Teams for Innovation and Research,Innovation Project of Guangxi Graduate Education(No.YCSW2025193)Guangxi Collaborative Innovation Center of Multi-source Information Integration and Intelligent Processing.
文摘In educational settings,instructors often lead students through hands-on software projects,sometimes engaging two different schools or departments.How can such collaborations be made more efficient,and how can students truly experience the importance of teamwork and the impact of organizational structure on project complexity?To answer these questions,we introduce the requirement-driven organization structure(R-DOS)approach,which tightly couples software requirements with the actual development process.By extending problem-frames modeling and focusing on requirements,R-DOS allows educators and students to(1)diagnose structural flaws early,(2)prescribe role-level and communication fixes,and(3)observe-in real time-how poor structure can derail a project while good structure accelerates learning and delivery.
文摘Generalised reduced masses with a set of equations governing the three relative motions between two of 3-bodies in their gravitational field are established,of which the dynamic characteristics of 3-body dynamics,fundamental bases of this paper,are revealed.Based on these findings,an equivalent system is developed,which is a 2-body system with its total mass,constant angular momentum,kinetic and potential energies same as the total ones of three relative motions,so that it can be solved using the well-known theory of the 2-body system.From the solution of an equivalent system with the revealed characteristics of three relative motions,the general theoretical solutions of the 3-body system are obtained in the curve-integration forms along the orbits in the imaged radial motion space.The possible periodical orbits with generalised Kepler’s law are presented.Following the description and mathematical demonstrations of the proposed methods,the examples including Euler’s/Lagrange’s problems,and a reported numerical one are solved to validate the proposed methods.The methods derived from the 3-body system are extended to N-body problems.
文摘Sensitivity of observational data is important in the study of Glacial Isostatic Adjustment(GIA).However,depending on whether sensitivity is used for the Inverse Problem or the Forward Problem,the final formulation and display of the sensitivity kernel will be different.Unfortunately,in the past,both perspectives give the same name to their quantity computed/displayed,and that has caused some confusion.To distinguish between the two,their perspective should be added to the names.This paper focuses only on the perspective of the Forward Problem where the input parameters are known.The Perturbation method has been successfully used in the computation of the sensitivity kernels of observations on 1D and 3D viscosity variations from the Forward perspective.One aim of this paper is to review and clarify the physics of the Perturbation method and bring out some important aspects of this method that have been misunderstood or neglected.Another aim is to present sensitivity kernels from the Perturbation method using 3D(both radially and laterally heterogeneous)Earth models with realistic ice history.These new results are now suitable for future comparison with those from new methods using the Forward perspective.Finally,the sensitivity computations for realistic ice histories on a 3D Earth is reviewed and used to search for optimal locations of new GIA observations.
