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DPP-4抑制剂联合用药在治疗糖尿病及并发症中的应用
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作者 董琳 徐雅莉 李清 《华西药学杂志》 北大核心 2025年第5期595-599,共5页
二肽基肽酶-Ⅳ(DPP-4)抑制剂作为治疗2型糖尿病的二线药物,具有良好的血糖控制能力和较少的不良反应。现基于DPP-4抑制剂的研究现状,综述其联合用药方案在1型、2型糖尿病及其并发症中的应用,以期为临床应用提供依据。
关键词 二肽基肽酶-Ⅳ抑制剂 联合用药 1型糖尿病 2型糖尿病及其并发症治疗 二甲双胍
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DPP4-Nestin轴在泡球蚴感染所致肝纤维化的促进作用及机制
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作者 高瑾 孙涛 +11 位作者 木克西娜·木拉提 何小龙 石晶 李亮 杨宁 楚瑨 张雪 刘辉 吕国栋 林仁勇 毕晓娟 郭庆勇 《中国兽医学报》 北大核心 2025年第2期298-304,共7页
为探讨DPP4-Nestin轴在泡球蚴感染引起肝纤维化过程中的作用,选取C57BL/6小鼠通过肝门静脉构建泡球蚴感染模型,HE法检测肝脏组织病理学变化,免疫组化、免疫荧光检测Nestin及DPP4在泡球蚴感染小鼠肝脏中的表达;以DPP4重组蛋白刺激小鼠肝... 为探讨DPP4-Nestin轴在泡球蚴感染引起肝纤维化过程中的作用,选取C57BL/6小鼠通过肝门静脉构建泡球蚴感染模型,HE法检测肝脏组织病理学变化,免疫组化、免疫荧光检测Nestin及DPP4在泡球蚴感染小鼠肝脏中的表达;以DPP4重组蛋白刺激小鼠肝星状细胞系JS1构建体外模型,qPCR、Western blot、shRNA慢病毒干扰等方法检测DPP4-Nestin轴在肝星状细胞激活过程中的作用。结果显示:与Sham组相比,泡球蚴感染组肝脏组织结构破坏,胶原沉积明显,Nestin和DPP4表达显著升高(P<0.050 0),且Nesin与α-SMA存在共定位;与对照组相比,DPP4重组蛋白刺激可明显刺激JS1细胞激活(P<0.050 0),并且Nestin表达升高(P<0.050 0),shRNA慢病毒抑制JS1细胞Nestin表达可明显抑制DPP4重组蛋白对JS1细胞的活化作用(P<0.050 0)。综上所述,DPP4-Nestin轴在泡球蚴感染引起肝星状细胞活化过程中具有重要调节作用,靶向DPP4-Nestin轴可作为治疗泡球蚴感染所致肝纤维化的新途径。 展开更多
关键词 泡型棘球蚴 NESTIN dpp4 小鼠
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以DPP4为靶点探讨中药对RA的干预作用
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作者 魏建中 孙继佳 +3 位作者 袁颖 张磊 李成蹊 王健英 《中国民族民间医药》 2025年第17期59-64,76,共7页
二肽基肽酶IV(DPP4)属于丝氨酸蛋白酶家族,可以水解多种蛋白质,执行多种重要的生物学功能。目前已上市的DPP4抑制剂主要用于糖尿病,但长期使用会产生严重的类风湿关节炎症状。越来越多的研究信息表明DPP4与RA具有联系。中药具有多成分... 二肽基肽酶IV(DPP4)属于丝氨酸蛋白酶家族,可以水解多种蛋白质,执行多种重要的生物学功能。目前已上市的DPP4抑制剂主要用于糖尿病,但长期使用会产生严重的类风湿关节炎症状。越来越多的研究信息表明DPP4与RA具有联系。中药具有多成分、多途径、多靶点效用,在调节血糖和干预RA方面具有作用。文章归纳DPP4对RA的影响,以及中药对RA的干预作用,探讨中药是否可以通过调控DPP4,从而干预RA的发生发展,可为研究中药对DPP4的作用,开发能改善DPP4抑制剂副作用或作用于DPP4靶点干预RA的中药新药提供研究思路。 展开更多
关键词 二肽基肽酶IV(dpp4) 类风湿关节炎(RA) 中药 免疫
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First-principles study on the structure-property relationship of AlX and InX(X=N,P,As,Sb)
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作者 HE Zhihao DING Jiafu +1 位作者 WANG Yunjie SU Xin 《无机化学学报》 北大核心 2025年第5期1007-1019,共13页
This paper delves into the theoretical mechanisms of the electronic structure and optical properties of aluminum-based semiconductors(AlX,X=N,P,As,Sb)and indium-based semiconductors(InX,X=N,P,As,Sb)as potential materi... This paper delves into the theoretical mechanisms of the electronic structure and optical properties of aluminum-based semiconductors(AlX,X=N,P,As,Sb)and indium-based semiconductors(InX,X=N,P,As,Sb)as potential materials for optical devices.Band structure calculations reveal that,except for InSb,all other compounds are direct bandgap semiconductors,with AlN exhibiting a bandgap of 3.245 eV.The valence band maximum of these eight compounds primarily stems from the p-orbitals of Al/In and X.In contrast,the conduction band minimum is influenced by all orbitals,with a predominant contribution from the p-orbitals.The static dielectric constant increased with the expansion of the unit cell volume.Compared to AlX and InX with larger X atoms,AlN and InN showed broader absorption spectra in the near-ultraviolet region and higher photoelectric conductance.Regarding mechanical properties,AlN and InN displayed greater shear and bulk modulus than the other compounds.Moreover,among these eight crystal types,a higher modulus was associated with a lower light loss function value,indicating that AlN and InN have superior transmission efficiency and a wider spectral range in optoelectronic material applications. 展开更多
关键词 aluminium‑based semiconductor indium‑based semiconductor first principle electronic structure optical property
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First-principles Investigation of Heavy Metal Adsorption on C-lignin
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作者 WANG Juan JIA Leiyu +3 位作者 XU Yao ZHANG Zhenzhen DUAN Ziyu ALBINA Jan-Michael 《Journal of Wuhan University of Technology(Materials Science)》 2025年第6期1790-1794,共5页
We investigated the adsorption mechanisms including physical and chemical adsorption for heavy metals(Cd,Pb,Zn,Co,Cu)on C-lignin using density functional theory(DFT)simulations.Physical adsorption,involving metal atom... We investigated the adsorption mechanisms including physical and chemical adsorption for heavy metals(Cd,Pb,Zn,Co,Cu)on C-lignin using density functional theory(DFT)simulations.Physical adsorption,involving metal atoms near carbon atoms,is found to be endothermic;meanwhile,chemical adsorption,where hydroxyl groups replace metal ions,is exothermic and spontaneous.Pb exhibits the highest physical adsorption potential,while Cu and Co demonstrate the strongest chemical adsorption due to their highly negative adsorption energies.These findings provide valuable insights into the design of eco-friendly nano lignocellulosic composite films for effective heavy metal removal from contaminated water sources.Key words:C-lignin;adsorption;We investigated the adsorption mechanisms including physical and chemical adsorption for heavy metals(Cd,Pb,Zn,Co,Cu)on C-lignin using density functional theory(DFT)simulations.Physical adsorption,involving metal atoms near carbon atoms,is found to be endothermic;meanwhile,chemical adsorption,where hydroxyl groups replace metal ions,is exothermic and spontaneous.Pb exhibits the highest physical adsorption potential,while Cu and Co demonstrate the strongest chemical adsorption due to their highly negative adsorption energies.These findings provide valuable insights into the design of eco-friendly nano lignocellulosic composite films for effective heavy metal removal from contaminated water sources. 展开更多
关键词 C-lignin ADSORPTION heavy metal ions first principles calculations metal ions first principles calculations
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The Concretization of the Principle of Equality:A Hermeneutic Reconstruction of Article 33,Paragraph 4 of the Chinese Constitution
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作者 LIU Jianlong JIANG Yu(Translated) 《The Journal of Human Rights》 2025年第1期149-163,共15页
Traditional constitutional theory holds that Article 33,Paragraph 4 of the Chinese Constitution establishes the principle of the consistency of rights and obligations.However,with the evolution of constitutional theor... Traditional constitutional theory holds that Article 33,Paragraph 4 of the Chinese Constitution establishes the principle of the consistency of rights and obligations.However,with the evolution of constitutional theory and practice,its interpretation has shifted.It is increasingly viewed as a concretization of the principle of equality,although this perspective has not been thoroughly substantiated in academic circles.Upon closer analysis,interpreting this provision as the“consistency of rights and obligations”reveals several issues,including counterevidence from the constitutional drafting history,a lack of internal coherence,and a misalignment with the functions of the Constitution.By revisiting the specific context of this provision,it can be understood as an anti-privilege clause,serving as a special annotation of the equality principle.This approach enables a harmonious interpretation of this provision alongside other constitutional provisions. 展开更多
关键词 principle of the consistency of rights and obligations principle of equality anti-privilege
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RENEWING A TIMELESS BOND Commemorating 75 years of China-Myanmar ties and revitalizing the legacy of the Five Principles of Peaceful Coexistence
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作者 Hou Sheng 《China Report ASEAN》 2025年第6期60-63,共4页
Over 70 years ago,China proposed the Five Principles of Peaceful Coexistence,which were first embraced by countries such as Myanmar and gradually gained traction across Asia.The Five Principles eventually became widel... Over 70 years ago,China proposed the Five Principles of Peaceful Coexistence,which were first embraced by countries such as Myanmar and gradually gained traction across Asia.The Five Principles eventually became widely recognized norms in international relations and foundational principles of international law,contributing significantly to the post-World War II international order.Decades on,the Five Principles have not faded into history.Rather,they have demonstrated renewed relevance in today’s complex global landscape. 展开更多
关键词 Post World War II Order International Relations Five principles Peaceful Coexistence China five principles peaceful coexistencewhich Global Landscape International Law Myanmar
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DPP4蛋白检测在中医治疗风湿免疫病中的潜在作用研究
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作者 魏建中 王健英 《内蒙古中医药》 2025年第6期143-144,共2页
二肽基肽酶IV(DPP4)属于丝氨酸蛋白酶家族,DPP4能够对DPP4酶进行抑制,促进循环中的肠促胰岛素激素、胰高血糖素样肽-1、葡萄糖依赖性促胰岛素多肽的完整生物活性水平均得到提升。风湿免疫病与患者自身的免疫系统存在紧密的联系,极易加... 二肽基肽酶IV(DPP4)属于丝氨酸蛋白酶家族,DPP4能够对DPP4酶进行抑制,促进循环中的肠促胰岛素激素、胰高血糖素样肽-1、葡萄糖依赖性促胰岛素多肽的完整生物活性水平均得到提升。风湿免疫病与患者自身的免疫系统存在紧密的联系,极易加重关节多个器官系统的损伤。近年风湿免疫病逐渐运用中医治疗方案,能够发挥多靶点作用,因此本文主要对DPP4蛋白检测在中医治疗风湿免疫病中的潜在作用进行综述,以期为临床通过DPP4靶点治疗风湿免疫病的中药新药提供新的研究思路。 展开更多
关键词 二肽基肽酶IV(dpp4) 风湿免疫病 中医治疗 免疫
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Predicted stable two-dimensional semiconductor TiOS materials with promising photocatalytic properties:First-principles calculations
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作者 Pan Zhang Shihai Fu +2 位作者 Chunying Pu Xin Tang Dawei Zhou 《Chinese Physics B》 2025年第5期534-541,共8页
TiO_(2)is a well-known photocatalyst with a band gap of 3.2 eV,yet its ability to absorb light is limited to the short wavelengths of ultraviolet light.To achieve a more effective photocatalytic material,we have desig... TiO_(2)is a well-known photocatalyst with a band gap of 3.2 eV,yet its ability to absorb light is limited to the short wavelengths of ultraviolet light.To achieve a more effective photocatalytic material,we have designed two-dimensional semiconductor TiOS materials using swarm intelligence algorithms combined with first-principles calculations.Three stable low-energy structures with space groups of P2_(1)/m,P3m1 and P2_(1)/c are identified.Among these structures,the Janus P3m1 phase is a direct bandgap semiconductor,while the P2_(1)/m and P2_(1)/c phases are indirect bandgap semiconductors.Utilizing the accurate hybrid density functional HSE06 method,the band gaps of the three structures are calculated to be 2.34 eV(P2_(1)/m),2.24 eV(P3m1)and 3.22 eV(P2_(1)/c).Optical calculations reveal that TiOS materials exhibit a good light-harvesting capability in both visible and ultraviolet spectral ranges.Moreover,the photocatalytic calculations also indicate that both P2_(1)/m and P3m1 TiOS can provide a strong driving force for converting H_(2)O to H_(2)and O_(2)in an acidic environment with pH=0.The structural stabilities,mechanical properties,electronic structures and hydrogen evolution reaction activities are also discussed in detail.Our research suggests that two-dimensional TiOS materials have potential applications in both semiconductor devices and photocatalysis. 展开更多
关键词 first principles structure prediction TiOS semiconductor PHOTOCATALYSIS
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Structural and Electronic Properties of the Predicted Two-dimensional AsP_(2)X_(6)(X=S,Se):First-principles Calculations
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作者 PU Chunying ZHANG Pan +1 位作者 YIN Furong ZHOU Dawei 《Journal of Wuhan University of Technology(Materials Science)》 2025年第6期1612-1619,共8页
The structural,relative stability,and electronic properties of two-dimensional AsP_(2)X_(6)(X=S,Se)were predicted and studied using the particle-swarm optimization method and first principles calculations.We proposed ... The structural,relative stability,and electronic properties of two-dimensional AsP_(2)X_(6)(X=S,Se)were predicted and studied using the particle-swarm optimization method and first principles calculations.We proposed two low energy structures with P312 and P-31m phases,both of which the structures are hexagonal in shape and show non-centrosymmetry for the P312 phase and centrosymmetry for the P-31m phase.According to our results,two structural phases are found to be stable thermally and dynamically.The P312 phase of AsP_(2)X_(6)(X=S,Se)are indirect semiconductors with band gaps of 2.44 eV(AsP2S6)and 2.18 eV(AsP2Se6)at the HSE06 level,and their absorption coefficients are predicted to reach the order of 10^(5)cm^(-1)from visible light to ultraviolet region,but the main absorption is manly in the ultraviolet region.The P-31m phase of AsP_(2)X_(6)(X=S,Se)exhibits metal character with the Fermi surface mainly occupied by the p orbital of S/Se.Remarkably,estimated by first principles calculations,the P-31m AsP2S6 is found to be an intrinsic phonon-mediated superconductor with a relatively high critical superconducting temperature of about 13.4 K,and the P-31m AsP2Se6 only has a superconducting temperature of 1.4 K,which suggest that the P-31m AsP2S6 may be a good candidate for a nanoscale superconductor. 展开更多
关键词 first principles structure prediction electronic structure SUPERCONDUCTIVITY
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Design and Performance Test of an H-shaped Bionic Piezoelectric Robot Based on the Standing Wave Principle
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作者 Ying Li Chaofeng Li +2 位作者 Zhiwei Wu Binbin Zhu Jinghu Tang 《Journal of Bionic Engineering》 2025年第2期608-625,共18页
In this paper,inspired by the running motion gait of a cheetah,an H-shaped bionic piezoelectric robot(H-BPR)based on the standing wave principle is proposed and designed.The piezoelectric robot realizes linear motion,... In this paper,inspired by the running motion gait of a cheetah,an H-shaped bionic piezoelectric robot(H-BPR)based on the standing wave principle is proposed and designed.The piezoelectric robot realizes linear motion,turning motion,and turning motion with different radi by the voltage differential driving method.A prototype with a weight of 38 g and dimensions of 150×80×31 mm^(3) was fabricated.Firstly,the dynamics and kinematics of the piezoelectric robot were analyzed to obtain the trajectory of a point at the end of the piezoelectric robot leg.The motion principle of the piezo-electric robot was analyzed,and then the piezoelectric robot's modal analysis and harmonic response analysis were carried out using finite element analysis software.Finally,an experimental setup was built to verify the effectiveness and high efficiency of the robot's motion,and the effects of frequency,voltage,load,and height of the driving leg on the robot's motion performance were discussed.The performance test results show that the piezoelectric robot has a maximum veloc-ity of 66.79 mm/s at an excitation voltage of 320 V and a load capacity of 55 g.In addition,the H-BPR with unequal drive legs has better climbing performance,and the obtained conclusions are informative for selecting leg heights for piezoelectric robots. 展开更多
关键词 PIEZOELECTRIC Standing wave principle BIONIC Differential driving method ROBOT
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Exploring Communication in Travel Planning Among Friends: A Case Study Based on the Politeness Principle and Face Theory
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作者 XIE Shu-peng ZHANG Hao-ruo 《Journal of Literature and Art Studies》 2025年第7期594-598,共5页
In interpersonal communication,the principle of politeness is an important communicative principle that is widely applied in people’s daily life.However,the communication patterns of the principle of politeness and f... In interpersonal communication,the principle of politeness is an important communicative principle that is widely applied in people’s daily life.However,the communication patterns of the principle of politeness and face theory in the travel planning process among friends still need further exploration.This study aims to analyze the specific manifestations of these principles in the communication patterns of travel planning among friends through a pragmatic interpretation of the principle of politeness and face theory,providing a new perspective for understanding linguistic behavior in interpersonal relationships. 展开更多
关键词 The Politeness principle FRIENDSHIP face theory travel planning
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Humorous Effects in the Crosstalk Learning Manchu by Non-observance of Cooperative Principle
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作者 ZHENG Ling-yan 《Journal of Literature and Art Studies》 2025年第8期629-635,共7页
This paper analyzes the humorous effects generated through the non-observance of Grice’s Cooperative Principle(CP)in the Chinese crosstalk Learning Manchu.Focusing on violations of the Quantity,Quality,Relation,and M... This paper analyzes the humorous effects generated through the non-observance of Grice’s Cooperative Principle(CP)in the Chinese crosstalk Learning Manchu.Focusing on violations of the Quantity,Quality,Relation,and Manner maxims,it examines how deliberate pragmatic deviations create comedy.The study also incorporates the unique crosstalk mechanism of“Baofu”(packaging and delivering jokes)and emphasizes the essential role of audience cooperation in humor reception.It argues that humor in crosstalk arises not only from performers’non-cooperation but also from active audience engagement within a shared cultural context. 展开更多
关键词 non-observance of Cooperative principle humorous effect CROSSTALK audience cooperation
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A simulation and experimental study of a valveless piezoelectric micropump based on the synthetic jet principle
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作者 Wencheng Lv Jiafeng Ni +6 位作者 Weipeng Xuan Yixing Li Xiwei Huang Lingling Sun Hao Jin Shurong Dong Jikui Luo 《Nanotechnology and Precision Engineering》 2025年第2期86-94,共9页
A stacked piezoelectric micropump based on the synthetic jet principle with a size of 22×22×5 mm^(3) is designed and fabricated.Through theoretical and finite element method(FEM)analysis,the conditions for a... A stacked piezoelectric micropump based on the synthetic jet principle with a size of 22×22×5 mm^(3) is designed and fabricated.Through theoretical and finite element method(FEM)analysis,the conditions for achieving a synthetic jet structure are obtained,and the gas flow properties inside the chamber are analyzed.The first-order mode and resonant frequency of the piezoelectric actuator are simulated.At a resonant frequency of 22.5 kHz,the maximum central displacement of the actuator can reach 12.3μm.In addition,the key dimensions of the micropump are optimized to improve the output flow rate.Experiments on the prototype of the micropump show that it can reach a maximum output flow rate of 618 mL/min when driven by a sine wave signal of 42 Vpp and 22.5 kHz.The power dissipation does not exceed 600 mW. 展开更多
关键词 Piezoelectric actuator Piezoelectric valveless pump Synthetic jet principle
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Mathematical principle and engineering application of end-mining technology with non-pillar
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作者 Jianyong Qiao Zhiqiang Wang +1 位作者 Tingzhao Li Yun Zhao 《Earth Energy Science》 2025年第1期85-97,共13页
To ameliorate the difficulties of on-site dynamic disaster control in the end-mining stage of traditional mining engineering,this paper introduces the mathematical research and engineering application of the end-minin... To ameliorate the difficulties of on-site dynamic disaster control in the end-mining stage of traditional mining engineering,this paper introduces the mathematical research and engineering application of the end-mining technology system with non-pillar in mines(ETSNM)in recent years.The petal warning criterion for the stability of the surrounding rock of the roadway at the end-mining stage was obtained by studying the inverse problem of the petal theorem.A conformal mathematical model of the end-mining stage was established using the conformal mapping method,and the limit theorem of the peak point of mine pressure(LTPPMP)in the end-mining stage was demonstrated.Based on the cross-fusion of the above basic mathematical theory and the LTPPMP,a new ETSNM model was proposed,which includes no coal pillar,no dedicated retracement roadways,and fast retracement equipment(NNF).The mathematical principles of engineering technology for height control,speed limit,and roof cutting in the end-mining stage with non-pillar were revealed.The scientific and application values of the ETSNM were confirmed through engineering applications.Based on this,a new non-pillar control technology for dynamic disasters in the end-mining stage was proposed.The above research will play an active role in promoting the engineering application of ETSNM driven by mathematical theory. 展开更多
关键词 NON-PILLAR End-mining technology Mathematical principle Engineering application Dynamic disaster
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Composition design of gold-platinum alloy with ultra-low magnetic susceptibility:First-principles and experimental validation
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作者 Wei Wu Yanli Lu +5 位作者 Chenwei Zhai Lian Ouyang Wenqing Yang Rui Hu Yi Liu Quan Fu 《Journal of Materials Science & Technology》 2025年第8期62-71,共10页
Gold-platinum(Au-Pt)alloy has aroused considerable attention due to its ultra-low magnetic susceptibility(MS)in testing mass(TM)on spacecraft.However,the effect of Au content on the properties of the alloy has not yet... Gold-platinum(Au-Pt)alloy has aroused considerable attention due to its ultra-low magnetic susceptibility(MS)in testing mass(TM)on spacecraft.However,the effect of Au content on the properties of the alloy has not yet been understood.In this study,the composition design of Au-Pt alloy with ultra-low MS was achieved through density functional theory(DFT)and experimental methods.The elastic,thermal properties and electronic structure were systematically investigated,the composition range was further optimized and Au75Pt25 was determined to be the most suitable alloy for TM material.The phase composition of this alloy after cold rolling and solid solution was characterized,indicating a single-phase FCC structure.In addition,there is a good validation between the experimental Vickers hardness and the DFT results.This work provides new insights into the compositional optimization of Au-Pt alloys and lays the foundation for alloy development. 展开更多
关键词 Au-Pt alloy Ultra-low magnetic susceptibility Composition design First principles HAADF-STEM
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Belief reliability modeling and analysis for TPS considering physical principles,degradation mechanism and epistemic uncertainties
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作者 Dayu CHEN Yao LI +4 位作者 Yiyang SHANGGUAN Zhiqiang LI Zhenqiang WU Xiaoyang LI Rui KANG 《Chinese Journal of Aeronautics》 2025年第5期262-274,共13页
Thermal Protection System(TPS)with thick tiles,low thermal conductivity,and a short re-entry stage stands as a critical element within reusable aircraft,whose reliability is related to the function and changes with th... Thermal Protection System(TPS)with thick tiles,low thermal conductivity,and a short re-entry stage stands as a critical element within reusable aircraft,whose reliability is related to the function and changes with their physical properties,external conditions,and degradation.Meanwhile,due to the limitation of testing resources,epistemic uncertainties stemming from the small samples are present in TPS reliability modeling.However,current TPS reliability modeling methods face challenges in characterizing the relationships among reliability and physical properties,external conditions,degradation,and epistemic uncertainties.Therefore,under the framework of belief reliability theory,a TPS reliability model is constructed,which takes into account the physical principle,external conditions,performance degradation,and epistemic uncertainties.A reliability simulation algorithm is proposed to calculate TPS reliability.Through a case study and comparison analysis,the proposed method is validated as more effective than the existing method.Additionally,reliability sensitivity analysis is conducted to identify the sensitive factors of reliability under the condition of small samples,through which suggestions are provided for TPS functional design and improvement. 展开更多
关键词 Thermal protection system Physical principle Epistemic uncertainty Performance degradation Belief reliability modeling
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Comprehensive Integration of the Operational Principles of Diabetic Foot Therapeutic Devices with Technological Innovations
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作者 Jinting ZHOU Yanliang CHEN +3 位作者 Dongnian WU Lingjun HUANG Yao YAO Yu DIAO 《Medicinal Plant》 2025年第2期75-80,共6页
This paper offers a comprehensive overview of the operational principles of current therapeutic devices for diabetic foot management and further analyzes technological innovations and developmental trends,aiming to pr... This paper offers a comprehensive overview of the operational principles of current therapeutic devices for diabetic foot management and further analyzes technological innovations and developmental trends,aiming to promote research and development in the field of technological convergence.The ultimate goal is to enhance the cure rate for diabetic foot conditions and to decrease the incidence of amputations.The paper discusses the novel applications of ultrasound and optical therapeutic devices within the field of physiotherapy,the numerous advantages of chitosan dressings in biotechnology,the ongoing advancements and broader combined use of vacuum sealing drainage techniques,and the distinctive effects and innovations associated with micro-oxygen diffusion techniques.It thoroughly examines various technological mechanisms that facilitate wound healing,highlighting the clinical applications of ultrasonic atomized medicinal solutions,novel dressing graft copolymerization,continuous hypoxia diffusion,and the functions of vacuum drainage.These advancements facilitate the integration of drainage and dressing changes,with the potential to enhance the therapeutic effects of diabetic foot treatment and provide valuable insights for clinical application. 展开更多
关键词 Diabetic foot therapeutic device Operational principle Technological innovation Technological convergence
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Design Principles for High-Performance Meta-Polybenzimidazole Membranes for Vanadium Redox Flow Batteries
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作者 Jacobus C.Duburg Jonathan Avaro +4 位作者 Leonard Krupnik Bruno F.B.Silva Antonia Neels Thomas J.Schmidt Lorenz Gubler 《Energy & Environmental Materials》 2025年第1期80-91,共12页
The all-vanadium redox flow battery(VRFB)plays an important role in the energy transition toward renewable technologies by providing grid-scale energy storage.Their deployment,however,is limited by the lack of membran... The all-vanadium redox flow battery(VRFB)plays an important role in the energy transition toward renewable technologies by providing grid-scale energy storage.Their deployment,however,is limited by the lack of membranes that provide both a high energy efficiency and capacity retention.Typically,the improvement of the battery’s energy efficiency comes at the cost of its capacity retention.Herein,novel N-alkylated and N-benzylated meta-polybenzimidazole(m-PBI)membranes are used to understand the molecular requirements of the polymer electrolyte in a vanadium redox flow battery,providing an important toolbox for future research toward next-generation membrane materials in energy storage devices.The addition of an ethyl side chain to the m-PBI backbone increases its affinity toward the acidic electrolyte,thereby increasing its ionic conductivity and the corresponding energy efficiency of the VRFB cell from 70%to 78%at a current density of 200 mA cm^(-2).In addition,cells equipped with ethylated m-PBI showed better capacity retention than their pristine counterpart,respectively 91%versus 87%,over 200 cycles at 200 mA cm^(-2).The outstanding VRFB cycling performance,together with the low-cost and fluorine-free chemistry of the N-alkylated m-PBI polymer,makes this material a promising membrane to be used in next-generation VRFB systems. 展开更多
关键词 design principles energy storage devices membranes POLYBENZIMIDAZOLE vanadium redox flow batteries
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两种DPP-4抑制剂在2型糖尿病患者中的应用及对糖脂调控的影响
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作者 马燕 《黑龙江医学》 2025年第11期1352-1354,共3页
目的:比较西格列汀和维格列汀这两种二肽基肽酶-4(DPP-4)抑制剂在2型糖尿病患者中的应用效果及对血糖和血脂的调控作用。方法:选取2021年2月—2023年2月河南省郸城县人民医院就诊的150例2型糖尿病患者作为研究对象,按随机数表法分为西... 目的:比较西格列汀和维格列汀这两种二肽基肽酶-4(DPP-4)抑制剂在2型糖尿病患者中的应用效果及对血糖和血脂的调控作用。方法:选取2021年2月—2023年2月河南省郸城县人民医院就诊的150例2型糖尿病患者作为研究对象,按随机数表法分为西格列汀组(n=75)和维格列汀组(n=75),疗程均为12周。分别于治疗前后检测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并评估不良反应发生率情况。结果:治疗后,西格列汀组与维格列汀组的FPG、HbA1c水平均降低,且维格列汀组的FPG、HbA1c水平显著低于西格列汀组,差异均有统计学意义(t=3.707、4.602,P<0.05);维格列汀组TC、LDL-C水平显著低于西格列汀组,差异均有统计学意义(t=3.239、3.636,P<0.05);两组患者不良反应发生率比较,差异无统计学意义(χ^(2)=0.150,P>0.05)。结论:西格列汀与维格列汀都可以显著改善2型糖尿病患者的血糖控制和血脂指标,两者耐受性良好,且维格列汀的调控作用更为显著,为临床治疗提供了新的选择。 展开更多
关键词 2型糖尿病 二肽基肽酶-4抑制剂 西格列汀 维格列汀
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