AIM:To find out the most common primary diseases of drug-induced keratoconjunctivitis.METHODS:The clinical records of 18 patients with a confirmed diagnosis of drug-induced keratoconjunctivitis were retrospectively re...AIM:To find out the most common primary diseases of drug-induced keratoconjunctivitis.METHODS:The clinical records of 18 patients with a confirmed diagnosis of drug-induced keratoconjunctivitis were retrospectively reviewed.Primary diseases,categories of induced-drugs,numbers of daily drops,characteristics of keratoconjunctivitis,treatment,epithelization period,and un-corrected visual acuity(UCVA)were studied.Data were analyzed by SPSS 18.0.P〈0.05 were considered statistically significant.RESULTS:Primary diseases included glaucoma(n=6),herpes simplex keratitis(n=6;two patients were post-surgery of cataract),herpes zoster keratitis(n=1),keratitis after corneal foreign body taken(n=1)and keratitis/corneal ulcer with unknown etiology(n=4).Mean number of drugs was 3.3±1.5 and the frequency was 9±3.9 times a day.Keratopathy was found in 16 cases,while conjunctival changes were found only in 3 cases(One patient got corneal and conjunctival changes simultaneously).Withdrawing the drugs,preservative-free lubricants or autologous serum,and topical low dose steroid drops were used for treatment.After a mean period of 7±2.8d,symptoms began to relieve.The mean epithelization period was 21±8.8d.Mean pretreatment and post-treatment UCVA was 0.15±0.13 and 0.43±0.27,respectively(P=0.003).CONCLUSION:Viral keratitis and glaucoma are the most often events of drug-induced keratoconjunctivitis.展开更多
文摘AIM:To find out the most common primary diseases of drug-induced keratoconjunctivitis.METHODS:The clinical records of 18 patients with a confirmed diagnosis of drug-induced keratoconjunctivitis were retrospectively reviewed.Primary diseases,categories of induced-drugs,numbers of daily drops,characteristics of keratoconjunctivitis,treatment,epithelization period,and un-corrected visual acuity(UCVA)were studied.Data were analyzed by SPSS 18.0.P〈0.05 were considered statistically significant.RESULTS:Primary diseases included glaucoma(n=6),herpes simplex keratitis(n=6;two patients were post-surgery of cataract),herpes zoster keratitis(n=1),keratitis after corneal foreign body taken(n=1)and keratitis/corneal ulcer with unknown etiology(n=4).Mean number of drugs was 3.3±1.5 and the frequency was 9±3.9 times a day.Keratopathy was found in 16 cases,while conjunctival changes were found only in 3 cases(One patient got corneal and conjunctival changes simultaneously).Withdrawing the drugs,preservative-free lubricants or autologous serum,and topical low dose steroid drops were used for treatment.After a mean period of 7±2.8d,symptoms began to relieve.The mean epithelization period was 21±8.8d.Mean pretreatment and post-treatment UCVA was 0.15±0.13 and 0.43±0.27,respectively(P=0.003).CONCLUSION:Viral keratitis and glaucoma are the most often events of drug-induced keratoconjunctivitis.
