AIM: To elucidate the effect of saliva stimulation by nizatidine on oral symptoms of primary biliary cirrhosis (PBC) by administering it to PBC cases. METHODS: From among 73 cases that had been definitively diagnosed ...AIM: To elucidate the effect of saliva stimulation by nizatidine on oral symptoms of primary biliary cirrhosis (PBC) by administering it to PBC cases. METHODS: From among 73 cases that had been definitively diagnosed as PBC at our hospital by February 2010, we selected 27 cases of PBC, 4 males and 23 females, as subjects. We obtained subjects' consent after giving them a full explanation of the administration of nizatidine. Nizatidine 150 mg was administered internally twice daily, after morning and evening meals. To observe changes in the quantity of saliva secreted, chewing gum tests were carried out four times: before the initial dose, and after 6 mo, 12 mo and 24 mo of administration. For subjective dry mouth symptoms, a visual analog scale (VAS) method was used to assess their feelings of oral dryness and eating difficulty, five times: before the initial dose, and after 1, 6, 12 and 24 mo of administration in 8 cases. The nutritional condition and the hepatic functional reserve were compared between before and after the nizatidine treatment.RESULTS: The result of a chewing gum test on the subjects before the administration of nizatidine showed that 50% produced less than 10 mL of saliva, i.e. , the standard under which cases are considered to have hyposalivation. The results of these tests showed that the quantity of saliva secreted was 10.5 ± 6.8 mL before administration of nizatidine, 10.9 ± 6.0 mL after 6 mo, 10.6 ± 4.9 mL after 12 mo, and 11.8 ± 6.8 mL after 24 mo administration. Thus, there was a slowly increasing trend in the quantity of saliva in the whole group. The percentage of subjects with saliva production above 10 mL was 45.8% after 6 mo administration of nizatidine, that is, only a slight change from before its administration, but it was 64.3% after 12 mo, that is, a significant increase. The saliva secretion by subject patients was examined before the beginning of administration of nizatidine, 12 mo later, and 24 mo later, and Fisher's combined probability test was used to examine the results for increases in saliva secretion. The analysis yielded P values of 0.51 and 0.53 for 12 mo later and 24 mo later, respectively. Thus, although there was no statistically significant increase, it was confirmed that saliva secretion tended to increase. A VAS method was employed to study the intensities of subjective symptoms of oral dryness and eating difficulty. Almost every case indicated some improvement of subjective oral dryness on the VAS early in the administration, i.e. , one month after. We also studied the effects of the administration of nizatidine on nutritional condition, hepatic functional reserve, and long-term prognosis of PBC. No significant improvements in cholinesterase (ChE) level, albumin (Alb) level, or Child-Pugh score were found during the period of observation from the beginning to the end of administration of nizatidine, nor in comparison with the non-administration group. A comparative analysis between before administration and 24 mo later yielded P values of 0.41 for Alb, 0.56 for ChE, and 0.59 for the Child-Pugh scores. CONCLUSION: It was confirmed that administering nizatidine to cases of PBC with dry mouth increased the secretion of saliva and improved the symptoms.展开更多
AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary hypertension.METHODS:A cross-sectional study included 432 patients with primary hypertension(with an equal number o...AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary hypertension.METHODS:A cross-sectional study included 432 patients with primary hypertension(with an equal number of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy subjects as a control group.The Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 subjects.Subjects with OSDI scores<13 and Schirmer Ⅰ values equal to or under 10 mm were diagnosed with DE.RESULTS:The ratio of DE in hypertension patients was higher than in the control group(41.7%versus 18.8%;P<0.001).The proportion of patients with DE increased gradually according to the hypertension stage:27.1% in stage Ⅰ,40.3% in stage Ⅱ,and 57.6% in stage Ⅲ,P<0.001.Age,duration of hypertension,plasma urea,creatinine,and high-sensitivity C-reactive protein(CRP-hs)levels in hypertension patients with DE were higher than those without DE,P<0.001.Advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,P<0.001.CONCLUSION:DE is a common disorder associated with advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.展开更多
In the arid and semi-arid areas of China, rainfall and drought affect the growth and photosynthetic activities of plants.Gross primary productivity(GPP) is one of the most important indices that measure the photosynth...In the arid and semi-arid areas of China, rainfall and drought affect the growth and photosynthetic activities of plants.Gross primary productivity(GPP) is one of the most important indices that measure the photosynthetic ability of plants.This paper focused on the GPP of two representative grassland species(Stipa krylovii Roshev.and Allium polyrhizum Turcz.ex Regel) to demonstrate the effect of a temporal rainfall on the two species.Our research was conducted in a temperate grassland in New Barag Right Banner, Hulun Buir City, Inner Mongolia Autonomous Region of China, in a dry year 2015.We measured net ecosystem productivity(NEP) and ecosystem respiration flux(ER) using a transparent chamber system and monitored the photosynthetically active radiation(PAR), air and soil temperature and humidity simultaneously.Based on the measured values of NEP and ER, we calculated the GPP of the two species before and after the rainfall.The saturated GPP per aboveground biomass(GPPAGB) of A.polyrhizum remarkably increased from 0.033(±0.018) to 0.185(±0.055) μmol CO2/(gdw·s) by 5.6-fold and that of S.krylovii decreased from 0.068(±0.021) to 0.034(±0.011) μmol CO2/(gdw·s) by 0.5-fold on the 1st and 2nd d after a 9.1 mm rainfall event compared to the values before the rainfall at low temperatures below 35℃.However, on the 1st and 2nd d after the rainfall, both of the saturated GPPAGB values of S.krylovii and A.polyrhizum were significantly lower at high temperatures above 35℃(0.018(±0.007) and 0.110(±0.061) μmol CO2/(gdw·s), respectively) than at low temperatures below 35℃(0.034(±0.011) and 0.185(±0.055) μmol CO2/(gdw·s), respectively).The results showed that the GPP responses to the temporal rainfall differed between S.krylovii and A.polyrhizum and strongly negative influenced by temperature.The temporal rainfall seems to be more effective on the GPP of A.polyrhizum than S.krylovii.These differences might be related to the different physiological and structural features, the coexistence of the species and their species-specific survival strategies.展开更多
The recognition of the profound impact of the human gastrointestinal microbiome(GM) on human autoimmune diseases has gradually increased thanks to deeper research efforts. As a systemic autoimmune disease, primary Sjo...The recognition of the profound impact of the human gastrointestinal microbiome(GM) on human autoimmune diseases has gradually increased thanks to deeper research efforts. As a systemic autoimmune disease, primary Sjogren’s syndrome(pSS) cannot be completely cured. Human studies have revealed that GM species and diversity are altered in patients with p SS compared with healthy individuals. Animal studies have provided possible mechanisms for the association between pSS and GM. The potential role of GM in pSS is exerted through several mechanisms. GM dysbiosis leads to increased intestinal permeability, which increases the risk of GM antigen exposure and activates specific autoreactive T lymphocytes via “molecular mimicry”. In addition, GM antigen exposure and intestinal immune tolerance loss caused by GM dysbiosis together induce chronic local gut mucosal inflammation, which deteriorates to systemic chronic non-specific inflammation with the circulation of pro-inflammatory lymphocytes and cytokines. These factors eventually activate autoreactive B lymphocytes and lead to pSS. If GM plays a key role in the pathogenesis of pSS, clarifying the underlying mechanisms will be helpful for the development of new therapies targeting GM for dry eye associated with pSS. This review summarizes the latest knowledge about the relationship between GM and p SS,with the aim of contributing to future research and to the development of new clinical applications.展开更多
The Jamaican primary dry season extends from November-April with the driest period being January-March each year. Examination of the rainfall records over several decades reveal months that experienced a sharp increas...The Jamaican primary dry season extends from November-April with the driest period being January-March each year. Examination of the rainfall records over several decades reveal months that experienced a sharp increase in rainfall while sometimes they are drier than normal. During this dry season, some of the weather systems that impact the island significantly are cold fronts, highs pressure systems and troughs that migrate from the mainland USA. Major Sudden Stratospheric Warmings (SSW) occur routinely north of 60°N and severely impact weather over the North American continent. The islands of the Greater Antilles also experience inclement weather during this period as weather systems migrate southwards and impact the Caribbean. Severe winter weather due to the increase frequency and intensity of storms related to SSW events over North America is important to the Jamaican economy as tourists escape harsh winters by travelling to the island. Predicting the variability of rainfall during the primary dry season is therefore important as it has significant implications for event planning, tourism and agriculture. Cosmic-ray Muon flux has been found to be positively correlated with the atmospheric effective temperature used to indicate the occurrence of SSW events. Current research investigates the relationship between cosmic-ray Muon flux, SSW events and primary dry season rainfall. Our findings suggest that a significant change in rainfall occur over Jamaica during the primary dry season on average 29 days after the central date or on average 15 days after the SSW events end. Our study also suggests apparent similarities in the behaviour of cosmic-ray Muon flux over Jamaica to those when major SSW occurs at high latitudes. We therefore argue that the Muon detectors at low latitudes have practical use with respect to identifying SSWs and merits further study.展开更多
This study analyzed the impact of the local dry and rainy seasons on diurnal temperature range (DTR), for each major climatic zone of Nigeria namely the tropical monsoon, tropical savannah and semi-arid, using meteoro...This study analyzed the impact of the local dry and rainy seasons on diurnal temperature range (DTR), for each major climatic zone of Nigeria namely the tropical monsoon, tropical savannah and semi-arid, using meteorological data from thirteen observation stations for the period 1981 to 2021. DTR was computed from the difference of minimum temperature from maximum temperature and yearly and forty one years’ monthly averages of DTR and rainfall were computed and plotted in different graphs. The overall results from each climatic zone showed that DTR fluctuates with the seasons and there is an inverse relationship between DTR and rainfall whereby the value of DTR decreases as the rainy season approaches but increases as the rainy season departs ushering in the dry season or conversely DTR increases as the dry season approaches and decreases as the dry season departs ushering-in the rainy season. Secondly, the average yearly patterns of rainfall and DTR are roughly and oppositely shaped parabolas where the peak value of rainfall is diametrically opposite to the trough value of DTR and the least or nil volume of rainfall corresponds to the highest value of DTR. Thirdly, due to the yearly seasonal cycle of dry and rainy seasons in Nigeria coupled with the inverse relationship between DTR and Rainfall, the seasonal plot of DTR and rainfall is also cyclic in pattern with DTR cycle lagging 180 degrees with the rainfall cycle and the intersection of the two cycles represents the departure of one season and onset of another season while each half-cycle represents either the dry or rainy season. Fourthly, the dependence of DTR on any season at hand in Nigeria makes DTR season-forcing. This fourth result is underpinned by a result that showed that the 1981 and 2021 patterns of DTR and 1981 and 2021 patterns of rainfall when compared were similar, the differences were in the volume of rainfall which was due to climate change that has taken place over the four decades and which also impacted DTR since DTR varies inversely with rainfall. Finally and notwithstanding the common grounds of the results stated above, the result further showed that each climatic zone of Nigeria reacts differently to the local and global climate changes leading to the magnitude of DTR and the volume of rainfall being different across climatic zones, with rainfall volume and duration decreasing towards the arid North from the Coastal South while contrariwise DTR increases towards the arid North from the Coastal South.展开更多
AIM:To evaluate ocular surface characteristics and dry eye symptoms in primary biliary cholangitis(PBC)patients with seasonal allergic conjunctivitis(SAC).METHODS:This retrospective case-control study included 73 PBC ...AIM:To evaluate ocular surface characteristics and dry eye symptoms in primary biliary cholangitis(PBC)patients with seasonal allergic conjunctivitis(SAC).METHODS:This retrospective case-control study included 73 PBC patients:38 with SAC(PBC+SAC group,38 eyes)and 35 controls(35 eyes).All the participants underwent comprehensive ocular surface assessment and ocular surface disease index(OSDI)scoring.The severity of ocular allergy in PBC+SAC group was indicated by total ocular symptom score(TOSS),and correlation analysis was carried out between TOSS and ocular parameters.RESULTS:Age(59.60±10.69y vs 58.72±11.13y,P=0.629)and gender distribution(34 vs 32 females,P=0.713)did not differ significantly between groups.Compared to controls,the PBC+SAC group had higher dry eye prevalence(65.79%vs 28.57%,P=0.002),higher OSDI score[median:34.3(interquartile range,IQR:26.05,43.6)vs 21.2(IQR:15.15,31.2),P<0.001],shorter non-invasive tear film breakup time[NIBUT,median:4.16s(IQR:2.52,6.48)vs 6.88s(IQR:4.81,9.28),P<0.001],more severe upper meibomian gland loss(P<0.001),higher corneal fluorescein staining score[median:1(IQR:0,1)vs 0(IQR:0,0.25),P<0.001],and higher rates of meibomian gland duct thinning(60.53%vs 31.43%,P=0.004)and distortion(73.68%vs 25.71%,P=0.001).TOSS was positively correlated with OSDI score(r=0.484,P<0.001)in PBC+SAC group but not with other ocular parameters(all P>0.05).CONCLUSION:PBC patients with SAC have higher dry eye prevalence and more severe dry eye symptoms,mainly evaporative dry eye with obvious upper meibomian gland morphological abnormalities.Allergic symptom severity is positively correlated with dry eye discomfort,suggesting allergic inflammation may exacerbate ocular surface burden in PBC patients.展开更多
Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low wate...Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low water solubility, poor bioavailability and rapid metabolism significantly limits clinical applications. Here we developed a liposomal curcumin dry powder inhaler(LCD) for inhalation treatment of primary lung cancer. LCDs were obtained from curcumin liposomes after freeze-drying. The LCDs had a mass mean aerodynamic diameter of 5.81 μm and a fine particle fraction of 46.71%, suitable for pulmonary delivery. The uptake of curcumin liposomes by human lung cancer A549 cells was markedly greater and faster than that of free curcumin. The high cytotoxicity on A549 cells and the low cytotoxicity of curcumin liposomes on normal human bronchial BEAS-2B epithelial cells yielded a high selection index partly due to increased cell apoptosis. Curcumin powders, LCDs and gemcitabine were directly sprayed into the lungs of rats with lung cancer through the trachea. LCDs showed higher anticancer effects than the other two medications with regard to pathology and the expression of many cancer-related markers including VEGF, malondialdehyde, TNF-α, caspase-3 and BCL-2. LCDs are a promising medication for inhalation treatment of lung cancer with high therapeutic efficiency.展开更多
Negative effect of precipitation on plant photosynthesis was investigated in this work. Stomatal conductance, transpiration rate and net photosynthetic rate were measured before and after each precipitation event, res...Negative effect of precipitation on plant photosynthesis was investigated in this work. Stomatal conductance, transpiration rate and net photosynthetic rate were measured before and after each precipitation event, respectively, and the corresponding precipitation was recorded as well. Moreover, plant dry matter accumulation was counted at the end of our entire experiment. The results show that precipitation fully demonstrates its negative effect on plant photosynthesis under the condition of without water shortage. Although it has not been proved, leaf shape seems to be associated with this effect. Broad-leaved species are less influenced than coniferous and lanceleaf species no matter on the length of variation time or changes in variation values. The different situation among three broad-leaved species seems to illustrate that the effect is also related to the size of single leaf area. The correlation between precipitation and photosynthetic rate variation is analogous to the relationship between precipitation and splash erosion, and in the view of the relationship between plant photosynthetic characteristics and dry mass accumulation, it can be thought that it can reflect the negative impact of precipitation on plant growth by making use of splash erosion. Therefore, a section was added in the traditional plant biomass estimation algorithms by using eco-physiological models, and this was proved to enhance the accuracy of traditional estimation from preliminary verifications.展开更多
Aim European and North american studies have suggested that nitrogen(N)depositions reduce plant diversity and increase primary pro-ductivity due to changes in plant traits.To predict the vegetation response to future ...Aim European and North american studies have suggested that nitrogen(N)depositions reduce plant diversity and increase primary pro-ductivity due to changes in plant traits.To predict the vegetation response to future global change,experimental validations from other regions are widely needed.We assessed the effects of N treat-ment by urea fertilization on the diversity and biomass of the her-baceous plant traits(HPTs)in a dry tropical environment of India.Methods Diversity and biomass of different HPTs were determined on the basis of data collected in year 2010,from 135,1 m×1 m plots dis-tributed over 15 locations.The plots were treated with urea fertilizer in different doses(Control,60 kgNha−1 yr−1 and 120 kg N ha−1yr−1)since 1st January 2007.The plots were ordinated and data were subjected to appropriate statistical analyses.Important Findings Correspondence analysis(Ca)suggested uniqueness of species composition due to N amendment.species number and biomass of the trait categories varied due to N fertilization and traits.all studied trait categories(except N-fixers)yielded maximum mean species number at moderate level of N fertilization.Different levels of N fer-tilization exhibited different species diversity-primary productivity(D-P)relationships.Further,study showed reduction in plant diver-sity due to increase in biomass at high rates of N addition.Conclusions Tall,erect,non N-fixers,annuals,grasses HPTs were favoured by N enrichment.N dose above 60 kg enhanced the biomass of fast grow-ing,erect,annuals,non N-fixers,nitrophilic HPTs.The changes in traits with N addition,especially the increase in annuals and grasses and decrease in typically N-rich N-fixers,have implications for sus-tainable cattle production.展开更多
文摘AIM: To elucidate the effect of saliva stimulation by nizatidine on oral symptoms of primary biliary cirrhosis (PBC) by administering it to PBC cases. METHODS: From among 73 cases that had been definitively diagnosed as PBC at our hospital by February 2010, we selected 27 cases of PBC, 4 males and 23 females, as subjects. We obtained subjects' consent after giving them a full explanation of the administration of nizatidine. Nizatidine 150 mg was administered internally twice daily, after morning and evening meals. To observe changes in the quantity of saliva secreted, chewing gum tests were carried out four times: before the initial dose, and after 6 mo, 12 mo and 24 mo of administration. For subjective dry mouth symptoms, a visual analog scale (VAS) method was used to assess their feelings of oral dryness and eating difficulty, five times: before the initial dose, and after 1, 6, 12 and 24 mo of administration in 8 cases. The nutritional condition and the hepatic functional reserve were compared between before and after the nizatidine treatment.RESULTS: The result of a chewing gum test on the subjects before the administration of nizatidine showed that 50% produced less than 10 mL of saliva, i.e. , the standard under which cases are considered to have hyposalivation. The results of these tests showed that the quantity of saliva secreted was 10.5 ± 6.8 mL before administration of nizatidine, 10.9 ± 6.0 mL after 6 mo, 10.6 ± 4.9 mL after 12 mo, and 11.8 ± 6.8 mL after 24 mo administration. Thus, there was a slowly increasing trend in the quantity of saliva in the whole group. The percentage of subjects with saliva production above 10 mL was 45.8% after 6 mo administration of nizatidine, that is, only a slight change from before its administration, but it was 64.3% after 12 mo, that is, a significant increase. The saliva secretion by subject patients was examined before the beginning of administration of nizatidine, 12 mo later, and 24 mo later, and Fisher's combined probability test was used to examine the results for increases in saliva secretion. The analysis yielded P values of 0.51 and 0.53 for 12 mo later and 24 mo later, respectively. Thus, although there was no statistically significant increase, it was confirmed that saliva secretion tended to increase. A VAS method was employed to study the intensities of subjective symptoms of oral dryness and eating difficulty. Almost every case indicated some improvement of subjective oral dryness on the VAS early in the administration, i.e. , one month after. We also studied the effects of the administration of nizatidine on nutritional condition, hepatic functional reserve, and long-term prognosis of PBC. No significant improvements in cholinesterase (ChE) level, albumin (Alb) level, or Child-Pugh score were found during the period of observation from the beginning to the end of administration of nizatidine, nor in comparison with the non-administration group. A comparative analysis between before administration and 24 mo later yielded P values of 0.41 for Alb, 0.56 for ChE, and 0.59 for the Child-Pugh scores. CONCLUSION: It was confirmed that administering nizatidine to cases of PBC with dry mouth increased the secretion of saliva and improved the symptoms.
文摘AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary hypertension.METHODS:A cross-sectional study included 432 patients with primary hypertension(with an equal number of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy subjects as a control group.The Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 subjects.Subjects with OSDI scores<13 and Schirmer Ⅰ values equal to or under 10 mm were diagnosed with DE.RESULTS:The ratio of DE in hypertension patients was higher than in the control group(41.7%versus 18.8%;P<0.001).The proportion of patients with DE increased gradually according to the hypertension stage:27.1% in stage Ⅰ,40.3% in stage Ⅱ,and 57.6% in stage Ⅲ,P<0.001.Age,duration of hypertension,plasma urea,creatinine,and high-sensitivity C-reactive protein(CRP-hs)levels in hypertension patients with DE were higher than those without DE,P<0.001.Advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,P<0.001.CONCLUSION:DE is a common disorder associated with advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.
基金jointly supported by the National Natural Science Foundation of China (31470504, 31670455)the Grant-in-Aid for Scientific Research by the Japan Society for the Promotion of Science (grant 23405001)the National Key Research and Development Program of China (2016YFC0500908)
文摘In the arid and semi-arid areas of China, rainfall and drought affect the growth and photosynthetic activities of plants.Gross primary productivity(GPP) is one of the most important indices that measure the photosynthetic ability of plants.This paper focused on the GPP of two representative grassland species(Stipa krylovii Roshev.and Allium polyrhizum Turcz.ex Regel) to demonstrate the effect of a temporal rainfall on the two species.Our research was conducted in a temperate grassland in New Barag Right Banner, Hulun Buir City, Inner Mongolia Autonomous Region of China, in a dry year 2015.We measured net ecosystem productivity(NEP) and ecosystem respiration flux(ER) using a transparent chamber system and monitored the photosynthetically active radiation(PAR), air and soil temperature and humidity simultaneously.Based on the measured values of NEP and ER, we calculated the GPP of the two species before and after the rainfall.The saturated GPP per aboveground biomass(GPPAGB) of A.polyrhizum remarkably increased from 0.033(±0.018) to 0.185(±0.055) μmol CO2/(gdw·s) by 5.6-fold and that of S.krylovii decreased from 0.068(±0.021) to 0.034(±0.011) μmol CO2/(gdw·s) by 0.5-fold on the 1st and 2nd d after a 9.1 mm rainfall event compared to the values before the rainfall at low temperatures below 35℃.However, on the 1st and 2nd d after the rainfall, both of the saturated GPPAGB values of S.krylovii and A.polyrhizum were significantly lower at high temperatures above 35℃(0.018(±0.007) and 0.110(±0.061) μmol CO2/(gdw·s), respectively) than at low temperatures below 35℃(0.034(±0.011) and 0.185(±0.055) μmol CO2/(gdw·s), respectively).The results showed that the GPP responses to the temporal rainfall differed between S.krylovii and A.polyrhizum and strongly negative influenced by temperature.The temporal rainfall seems to be more effective on the GPP of A.polyrhizum than S.krylovii.These differences might be related to the different physiological and structural features, the coexistence of the species and their species-specific survival strategies.
基金Supported by the Science and Technology Program for Basic Research in Shenzhen (No.JCYJ20200109140412476)Clinical Research Project of Shenzhen Second People’s Hospital in 2019 (No.20193357009)。
文摘The recognition of the profound impact of the human gastrointestinal microbiome(GM) on human autoimmune diseases has gradually increased thanks to deeper research efforts. As a systemic autoimmune disease, primary Sjogren’s syndrome(pSS) cannot be completely cured. Human studies have revealed that GM species and diversity are altered in patients with p SS compared with healthy individuals. Animal studies have provided possible mechanisms for the association between pSS and GM. The potential role of GM in pSS is exerted through several mechanisms. GM dysbiosis leads to increased intestinal permeability, which increases the risk of GM antigen exposure and activates specific autoreactive T lymphocytes via “molecular mimicry”. In addition, GM antigen exposure and intestinal immune tolerance loss caused by GM dysbiosis together induce chronic local gut mucosal inflammation, which deteriorates to systemic chronic non-specific inflammation with the circulation of pro-inflammatory lymphocytes and cytokines. These factors eventually activate autoreactive B lymphocytes and lead to pSS. If GM plays a key role in the pathogenesis of pSS, clarifying the underlying mechanisms will be helpful for the development of new therapies targeting GM for dry eye associated with pSS. This review summarizes the latest knowledge about the relationship between GM and p SS,with the aim of contributing to future research and to the development of new clinical applications.
文摘The Jamaican primary dry season extends from November-April with the driest period being January-March each year. Examination of the rainfall records over several decades reveal months that experienced a sharp increase in rainfall while sometimes they are drier than normal. During this dry season, some of the weather systems that impact the island significantly are cold fronts, highs pressure systems and troughs that migrate from the mainland USA. Major Sudden Stratospheric Warmings (SSW) occur routinely north of 60°N and severely impact weather over the North American continent. The islands of the Greater Antilles also experience inclement weather during this period as weather systems migrate southwards and impact the Caribbean. Severe winter weather due to the increase frequency and intensity of storms related to SSW events over North America is important to the Jamaican economy as tourists escape harsh winters by travelling to the island. Predicting the variability of rainfall during the primary dry season is therefore important as it has significant implications for event planning, tourism and agriculture. Cosmic-ray Muon flux has been found to be positively correlated with the atmospheric effective temperature used to indicate the occurrence of SSW events. Current research investigates the relationship between cosmic-ray Muon flux, SSW events and primary dry season rainfall. Our findings suggest that a significant change in rainfall occur over Jamaica during the primary dry season on average 29 days after the central date or on average 15 days after the SSW events end. Our study also suggests apparent similarities in the behaviour of cosmic-ray Muon flux over Jamaica to those when major SSW occurs at high latitudes. We therefore argue that the Muon detectors at low latitudes have practical use with respect to identifying SSWs and merits further study.
文摘This study analyzed the impact of the local dry and rainy seasons on diurnal temperature range (DTR), for each major climatic zone of Nigeria namely the tropical monsoon, tropical savannah and semi-arid, using meteorological data from thirteen observation stations for the period 1981 to 2021. DTR was computed from the difference of minimum temperature from maximum temperature and yearly and forty one years’ monthly averages of DTR and rainfall were computed and plotted in different graphs. The overall results from each climatic zone showed that DTR fluctuates with the seasons and there is an inverse relationship between DTR and rainfall whereby the value of DTR decreases as the rainy season approaches but increases as the rainy season departs ushering in the dry season or conversely DTR increases as the dry season approaches and decreases as the dry season departs ushering-in the rainy season. Secondly, the average yearly patterns of rainfall and DTR are roughly and oppositely shaped parabolas where the peak value of rainfall is diametrically opposite to the trough value of DTR and the least or nil volume of rainfall corresponds to the highest value of DTR. Thirdly, due to the yearly seasonal cycle of dry and rainy seasons in Nigeria coupled with the inverse relationship between DTR and Rainfall, the seasonal plot of DTR and rainfall is also cyclic in pattern with DTR cycle lagging 180 degrees with the rainfall cycle and the intersection of the two cycles represents the departure of one season and onset of another season while each half-cycle represents either the dry or rainy season. Fourthly, the dependence of DTR on any season at hand in Nigeria makes DTR season-forcing. This fourth result is underpinned by a result that showed that the 1981 and 2021 patterns of DTR and 1981 and 2021 patterns of rainfall when compared were similar, the differences were in the volume of rainfall which was due to climate change that has taken place over the four decades and which also impacted DTR since DTR varies inversely with rainfall. Finally and notwithstanding the common grounds of the results stated above, the result further showed that each climatic zone of Nigeria reacts differently to the local and global climate changes leading to the magnitude of DTR and the volume of rainfall being different across climatic zones, with rainfall volume and duration decreasing towards the arid North from the Coastal South while contrariwise DTR increases towards the arid North from the Coastal South.
基金Supported by Beijing YouAn Hospital Construction of Talent Pool Program(No.YARCKB2024001).
文摘AIM:To evaluate ocular surface characteristics and dry eye symptoms in primary biliary cholangitis(PBC)patients with seasonal allergic conjunctivitis(SAC).METHODS:This retrospective case-control study included 73 PBC patients:38 with SAC(PBC+SAC group,38 eyes)and 35 controls(35 eyes).All the participants underwent comprehensive ocular surface assessment and ocular surface disease index(OSDI)scoring.The severity of ocular allergy in PBC+SAC group was indicated by total ocular symptom score(TOSS),and correlation analysis was carried out between TOSS and ocular parameters.RESULTS:Age(59.60±10.69y vs 58.72±11.13y,P=0.629)and gender distribution(34 vs 32 females,P=0.713)did not differ significantly between groups.Compared to controls,the PBC+SAC group had higher dry eye prevalence(65.79%vs 28.57%,P=0.002),higher OSDI score[median:34.3(interquartile range,IQR:26.05,43.6)vs 21.2(IQR:15.15,31.2),P<0.001],shorter non-invasive tear film breakup time[NIBUT,median:4.16s(IQR:2.52,6.48)vs 6.88s(IQR:4.81,9.28),P<0.001],more severe upper meibomian gland loss(P<0.001),higher corneal fluorescein staining score[median:1(IQR:0,1)vs 0(IQR:0,0.25),P<0.001],and higher rates of meibomian gland duct thinning(60.53%vs 31.43%,P=0.004)and distortion(73.68%vs 25.71%,P=0.001).TOSS was positively correlated with OSDI score(r=0.484,P<0.001)in PBC+SAC group but not with other ocular parameters(all P>0.05).CONCLUSION:PBC patients with SAC have higher dry eye prevalence and more severe dry eye symptoms,mainly evaporative dry eye with obvious upper meibomian gland morphological abnormalities.Allergic symptom severity is positively correlated with dry eye discomfort,suggesting allergic inflammation may exacerbate ocular surface burden in PBC patients.
文摘Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low water solubility, poor bioavailability and rapid metabolism significantly limits clinical applications. Here we developed a liposomal curcumin dry powder inhaler(LCD) for inhalation treatment of primary lung cancer. LCDs were obtained from curcumin liposomes after freeze-drying. The LCDs had a mass mean aerodynamic diameter of 5.81 μm and a fine particle fraction of 46.71%, suitable for pulmonary delivery. The uptake of curcumin liposomes by human lung cancer A549 cells was markedly greater and faster than that of free curcumin. The high cytotoxicity on A549 cells and the low cytotoxicity of curcumin liposomes on normal human bronchial BEAS-2B epithelial cells yielded a high selection index partly due to increased cell apoptosis. Curcumin powders, LCDs and gemcitabine were directly sprayed into the lungs of rats with lung cancer through the trachea. LCDs showed higher anticancer effects than the other two medications with regard to pathology and the expression of many cancer-related markers including VEGF, malondialdehyde, TNF-α, caspase-3 and BCL-2. LCDs are a promising medication for inhalation treatment of lung cancer with high therapeutic efficiency.
基金Project(TD2011-01)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(20133050)supported by the China Scholarship Council
文摘Negative effect of precipitation on plant photosynthesis was investigated in this work. Stomatal conductance, transpiration rate and net photosynthetic rate were measured before and after each precipitation event, respectively, and the corresponding precipitation was recorded as well. Moreover, plant dry matter accumulation was counted at the end of our entire experiment. The results show that precipitation fully demonstrates its negative effect on plant photosynthesis under the condition of without water shortage. Although it has not been proved, leaf shape seems to be associated with this effect. Broad-leaved species are less influenced than coniferous and lanceleaf species no matter on the length of variation time or changes in variation values. The different situation among three broad-leaved species seems to illustrate that the effect is also related to the size of single leaf area. The correlation between precipitation and photosynthetic rate variation is analogous to the relationship between precipitation and splash erosion, and in the view of the relationship between plant photosynthetic characteristics and dry mass accumulation, it can be thought that it can reflect the negative impact of precipitation on plant growth by making use of splash erosion. Therefore, a section was added in the traditional plant biomass estimation algorithms by using eco-physiological models, and this was proved to enhance the accuracy of traditional estimation from preliminary verifications.
文摘Aim European and North american studies have suggested that nitrogen(N)depositions reduce plant diversity and increase primary pro-ductivity due to changes in plant traits.To predict the vegetation response to future global change,experimental validations from other regions are widely needed.We assessed the effects of N treat-ment by urea fertilization on the diversity and biomass of the her-baceous plant traits(HPTs)in a dry tropical environment of India.Methods Diversity and biomass of different HPTs were determined on the basis of data collected in year 2010,from 135,1 m×1 m plots dis-tributed over 15 locations.The plots were treated with urea fertilizer in different doses(Control,60 kgNha−1 yr−1 and 120 kg N ha−1yr−1)since 1st January 2007.The plots were ordinated and data were subjected to appropriate statistical analyses.Important Findings Correspondence analysis(Ca)suggested uniqueness of species composition due to N amendment.species number and biomass of the trait categories varied due to N fertilization and traits.all studied trait categories(except N-fixers)yielded maximum mean species number at moderate level of N fertilization.Different levels of N fer-tilization exhibited different species diversity-primary productivity(D-P)relationships.Further,study showed reduction in plant diver-sity due to increase in biomass at high rates of N addition.Conclusions Tall,erect,non N-fixers,annuals,grasses HPTs were favoured by N enrichment.N dose above 60 kg enhanced the biomass of fast grow-ing,erect,annuals,non N-fixers,nitrophilic HPTs.The changes in traits with N addition,especially the increase in annuals and grasses and decrease in typically N-rich N-fixers,have implications for sus-tainable cattle production.
