China implemented its Action Plan of Air Pollution Prevention and Control(APAPPC)in 2013 as a major step in national air-quality management.This study treated the APAPPC as a quasi-experiment,drawing on the Grossman a...China implemented its Action Plan of Air Pollution Prevention and Control(APAPPC)in 2013 as a major step in national air-quality management.This study treated the APAPPC as a quasi-experiment,drawing on the Grossman and Cropper models,to examine how air pollution affected individual health capital and medical service demand.Using panel data from the China Health and Retirement Longitudinal Study for 2011,2013,2015,and 2018,the analysis applied a Heckman two-stage model and difference-in-differences estimation to identify the policy's effects on medical expenditure.The results showed that the APAPPC significantly reduced annual health spending,with stronger effects among women,older adults,and rural residents.The mechanism analysis indicated that the reduction in respiratory diseases played a key role.This study provides evidence that supports further airpollution control in China and offers useful insights for other developing countries.展开更多
Rabies is a zoonotic disease with an estimated global mortality of 59,000 people annually and a burden of more than 3.7 million disability-adjusted life years(DALYs)that is caused by a neurotropic lyssavirus[1].Dogs a...Rabies is a zoonotic disease with an estimated global mortality of 59,000 people annually and a burden of more than 3.7 million disability-adjusted life years(DALYs)that is caused by a neurotropic lyssavirus[1].Dogs are the primary source of human rabies,as more than 95%of human cases can be traced to dogs[2,3].China faces a substantial burden of rabies,having endured three major human rabies epidemics,which occurred in the 1950s,1981,and 2007[4].Implementation of various prevention and control measures has decreased the number of human rabies cases from 3,300 in 2007 to 167 in 2024.In China.展开更多
This study developed a modeling methodology for statistical optimization-based geologic hazard susceptibility assessment,aiming to enhance the comprehensive performance and classification accuracy of the assessment mo...This study developed a modeling methodology for statistical optimization-based geologic hazard susceptibility assessment,aiming to enhance the comprehensive performance and classification accuracy of the assessment models.First,the cumulative probability method revealed that a low probability(15%)of geologic hazards between any two geologic hazard points occurred outside a buffer zone with a radius of 2297 m(i.e.,the distance threshold).The training dataset was established,consisting of negative samples(non-hazard points)randomly generated based on the distance threshold,positive samples(i.e.,historical hazards),and 13 conditioning factors.Then,models were built using five machine learning algorithms,namely random forest(RF),gradient boosting decision tree(GBDT),naive Bayes(NB),logistic regression(LR),and support vector machine(SVM).The comprehensive performance of the models was assessed using the area under the receiver operating characteristic curve(AUC)and overall accuracy(OA)as indicators,revealing that RF exhibited the best performance,with OA and AUC values of 2.7127 and 0.981,respectively.Furthermore,the machine learning models constructed by considering the distance threshold outperformed those built using the unoptimized dataset.The characteristic factors were ranked using the mutual information method,with their scores decreasing in the order of rainfall(0.1616),altitude(0.06),normalized difference vegetation index(NDVI;0.04),and distance from roads(0.03).Finally,the geologic hazard susceptibility classification was assessed using the natural breaks method combined with a clustering algorithm.The results indicate that the clustering algorithm exhibited higher classification accuracy than the natural breaks method.The findings of this study demonstrate that the proposed model optimization scheme can provide a scientific basis for the prevention and control of geologic hazards.展开更多
To address uncertainty as well as transient stability constraints simultaneously in the preventive control of windfarm systems, a novel three-stage optimization strategy is established in this paper. In the first stag...To address uncertainty as well as transient stability constraints simultaneously in the preventive control of windfarm systems, a novel three-stage optimization strategy is established in this paper. In the first stage, the probabilisticmulti-objective particle swarm optimization based on the point estimate method is employed to cope with thestochastic factors. The transient security region of the system is accurately ensured by the interior point methodin the second stage. Finally, the verification of the final optimal objectives and satisfied constraints are enforcedin the last stage. Furthermore, the proposed strategy is a general framework that can combine other optimizationalgorithms. The proposed methodology is tested on the modified WSCC 9-bus system and the New England 39-bussystem. The results verify the feasibility of the method.展开更多
Water supply and drainage engineering is a key project in infrastructure construction, and various pipes, appliances and construction quality control are the key monitoring contents in water supply and drainage engine...Water supply and drainage engineering is a key project in infrastructure construction, and various pipes, appliances and construction quality control are the key monitoring contents in water supply and drainage engineering. In the face of people's increasing demand for water, the anti leakage problem in water supply and drainage engineering is more prominent. In order to solve the most concerned problems and improve the safety of water supply and drainage system, design, implementation and material use are very important for anti leakage treatment and prevention.展开更多
The construction enterprise tax risk as the breakthrough point, focus from existing obligations to pay taxes but did not declare and pay VAT, payment of accounts receivable in time after discount but did not open the ...The construction enterprise tax risk as the breakthrough point, focus from existing obligations to pay taxes but did not declare and pay VAT, payment of accounts receivable in time after discount but did not open the scarlet letter, engaged in ACTS related to invoices not accounted for separately, the issue VAT invoices, do not conform to the requirements of the specification of four aspects of building enterprise tax risk management assessment and prevention countermeasures.展开更多
This letter evaluates Shahid et al’s study in 2025 on the rising hepatitis A virus(HAV)among adults in Pakistan,highlighting a shift in the virus’s epidemiology.Once primarily a childhood disease in low-income regio...This letter evaluates Shahid et al’s study in 2025 on the rising hepatitis A virus(HAV)among adults in Pakistan,highlighting a shift in the virus’s epidemiology.Once primarily a childhood disease in low-income regions,HAV is now increasingly affecting adults,also seen globally due to improved sanitation.The study highlights public health challenges from adult HAV infections,which can lead to complications like coagulopathy and acute liver failure.It also has limitations,including being a single-center study and lacking seroprevalence and socioeconomic data,indicating the need for further research.This letter calls for urgent public health measures to extend adult vaccination programs and improve sanitation to address the increasing HAV infection in adult populations.展开更多
With the implementation of significant national strategies and rapid socioeconomic development,many ultra-long deep tunnels are being constructed in the Qinghai–Xizang Plateau region.However,the extreme complexity an...With the implementation of significant national strategies and rapid socioeconomic development,many ultra-long deep tunnels are being constructed in the Qinghai–Xizang Plateau region.However,the extreme complexity and variability of the environment in this region pose significant challenges to the safe construction and long-term operation of the planned or under-construction ultra-long deep tunnels.To address these complex technical challenges,this paper provides a detailed analysis of the complex climate and geology features of the Qinghai–Xizang Plateau during tunnel construction.The climate characteristics of the Qinghai–Xizang Plateau include severe coldness,low oxygen,and unpredictable weather changes.The geological characteristics include complex stress distributions caused by the intense internal and external dynamic coupling of tectonic plates,widespread active tectonic structures,frequent high-intensity earthquakes,fractured rock masses,and numerous active fault zones.Based on the analysis,this paper elaborates on potential sources of major disasters resulting from the characteristics of ultra-long deep tunnel projects in the Qinghai–Xizang Plateau region.These potential disaster sources include the crossing of active fault zones,high geostress rockbursts,large deformation disasters,high-pressure water surges,geothermal hazards,inadequate long-distance ventilation and oxygen supply,and multi-hazard couplings.In response to these challenges,this paper systematically summarizes the latest research progress and technological achievements in the domestic and international literature,and proposes innovative ideas and future development prospects for disaster monitoring and early warning,mechanized intelligent construction,long-term safety services,and emergency security and rescue.These innovative measures are intended to address the challenges of tunnel disaster prevention and control in the complex environment of the Qinghai–Xizang Plateau,contributing to the safe construction and long-term operation of ultra-long deep tunnels in this region.展开更多
With the depletion of shallow mineral resources,mining operations are extending to greater depths and larger scales,increasing the risk of water inrush disasters,particularly from confined aquifers intersected by faul...With the depletion of shallow mineral resources,mining operations are extending to greater depths and larger scales,increasing the risk of water inrush disasters,particularly from confined aquifers intersected by faults.This paper reviews the current state of research on fault-induced water inrushes in mining faces,examining the damage characteristics and permeability of fractured floor rock,the mechanical behavior of faults under mining stress,and the mechanisms driving water inrush.Advances in prevention technologies,risk assessment,and prediction methods are also summarized.Research shows that damage evolution in fractured floor rock,coupled with fluid-solid interactions,provides the primary pathways for water inrush.Stress-seepage coupling in porous media plays a decisive role in determining inrush potential.Mining-induced stress redistribution can activate faults,with parameters such as dip angle and internal friction angle controlling stress evolution and slip.Critical triggers include the hydraulic connectivity among faults,aquifers,and mining-induced fracture networks,followed by hydraulic erosion.A multi-pronged prevention framework has been developed,integrating precise fault detection,targeted grouting for water sealing,drainage to reduce water pressure,optimized waterproof coal pillar design,and dynamic risk assessment and prediction.However,gaps remain in understanding multi-physical field coupling under deep mining conditions,establishing quantitative criteria for fault activation-induced water inrush,and refining control technologies.Future work should focus on multi-scale numerical simulations,advanced active control measures,and intelligent,integrated prevention systems to clarify the mechanisms of fault-induced water inrush and enhance theoretical and technical support for mine safety.展开更多
As a major global public health issue,tuberculosis is closely related to multiple socio-ecological factors in its epidemiological patterns~([1]).China,as a high-burden country for tuberculosis,exhibits regional variat...As a major global public health issue,tuberculosis is closely related to multiple socio-ecological factors in its epidemiological patterns~([1]).China,as a high-burden country for tuberculosis,exhibits regional variations in the distribution of the tuberculosis epidemic.To enhance the efficiency of prevention and control,its strategies are undergoing a transition toward regionally differentiated approaches~([2]).展开更多
With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key...With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key functional molecules,has shown great potential in the field of disease prevention and control[1,2].The multi-continental transcriptomics study of tick-borne poxvirus not only provides a new perspective for understanding the evolution and transmission of vector-mediated viruses,but also reflects the trend of transcriptomics research and highlights its key role in disease prevention and control[3].展开更多
Probiotics show anti-influenza activity,offering a potential variant-resistant alternative for infection prevention and control.In this study,we evaluated whether a specially formulated yogurt enriched with synbiotics...Probiotics show anti-influenza activity,offering a potential variant-resistant alternative for infection prevention and control.In this study,we evaluated whether a specially formulated yogurt enriched with synbiotics(named yogurt 1)with 7 probiotics and 6 prebiotics,has anti-influenza effects and its underlying mechanisms using a mouse model challenged with influenza virus H1N1 PR8 strain.The mice were treated with phosphate-buffered saline(negative control),yogurt matrix,yogurt 1,and oseltamivir(positive control),respectively.Yogurt 1 treatment improved the survival of infected mice(from 0%to 30%),alleviated pathological injuries in the lungs and colon,and reduced the viral load of influenza virus on day 3 and day 7 post-infection.Yogurt 1 also downregulated some inflammation-related signaling pathways and reduced the levels of proinflammatory cytokines or chemokines in the lungs or serum,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α(TNF-α)and keratinocyte chemoattractant(KC).The levels of short-chain fatty acids in the cecal content were increased,the diversity of the intestinal flora was partially restored,and influenza-specific Ig G and interferon-secreting lymphocytes were enhanced following yogurt 1 administration.Thus,yogurt 1,as a commercial and easily accessible dairy product,demonstrated a notable anti-influenza effect in mice by inhibiting viral proliferation,suppressing excessive inflammatory responses,and promoting influenza virus-specific adaptive humoral and cellular immune responses,demonstrating its potential for influenza epidemic prevention and control.展开更多
BACKGROUND Colorectal cancer has a high incidence and mortality rate,and the effectiveness of routine colonoscopy largely depends on the endoscopist’s expertise.In recent years,computer-aided detection(CADe)systems h...BACKGROUND Colorectal cancer has a high incidence and mortality rate,and the effectiveness of routine colonoscopy largely depends on the endoscopist’s expertise.In recent years,computer-aided detection(CADe)systems have been increasingly integrated into colonoscopy to improve detection accuracy.However,while most studies have focused on adenoma detection rate(ADR)as the primary outcome,the more sensitive adenoma miss rate(AMR)has been less frequently analyzed.AIM To evaluate the effectiveness of CADe in colonoscopy and assess the advantages of AMR over ADR.METHODS A comprehensive literature search was conducted in PubMed,Embase,and the Cochrane Central Register of Controlled Trials using predefined search strategies to identify relevant studies published up to August 2,2024.Statistical analyses were performed to compare outcomes between groups,and potential publication bias was assessed using funnel plots.The quality of the included studies was evaluated using the Cochrane Risk of Bias tool and the Grading of Recommendations,Assessment,Development,and Evaluation approach.RESULTS Five studies comprising 1624 patients met the inclusion criteria.AMR was significantly lower in the CADe-assisted group than in the routine colonoscopy group(147/927,15.9%vs 345/960,35.9%;P<0.01).However,CADe did not provide a significant advantage in detecting advanced adenomas or lesions measuring 6-9 mm or≥10 mm.The polyp miss rate(PMR)was also lower in the CADe-assisted group[odds ratio(OR),0.35;95% confidence interval(CI):0.23-0.52;P<0.01].While the overall ADR did not differ significantly between groups,the ADR during the first-pass examination was higher in the CADe-assisted group(OR,1.37;95%CI:1.10-1.69;P=0.004).The level of evidence for the included randomized controlled trials was graded as moderate.CONCLUSION CADe can significantly reduce AMR and PMR while improving ADR during initial detection,demonstrating its potential to enhance colonoscopy performance.These findings highlight the value of CADe in improving the detection of colorectal neoplasms,particularly small and histologically distinct adenomas.展开更多
Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV)in poultry.ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K).Among them,ALV-J was first...Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV)in poultry.ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K).Among them,ALV-J was first introduced into China in 1999,spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens.ALV-J typically induces myeloid leukosis in infected chickens,but also induces a high proportion of hemangiomas in infected layer chickens,posing a serious threat to poultry breeds in China.As a retrovirus,the genome of ALV-J has undergone significant mutations,which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J.Over the last two decades,the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry.Specialized detection assays have been developed to combat ALV-J infections in China.Additionally,ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections.This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.展开更多
Benefit evaluation of debris flow prevention and control projects was one of the essential contents of debris flow prevention and mitigation work.In order to scientifically and quantitatively evaluate the comprehensiv...Benefit evaluation of debris flow prevention and control projects was one of the essential contents of debris flow prevention and mitigation work.In order to scientifically and quantitatively evaluate the comprehensive benefit of debris flow prevention and control projects,this study identified nine factors as evaluation indicators from economic,social,and ecological aspects.The projection pursuit(PP) model based on the improved particle swarm optimization(IPSO) algorithm was used to construct a mathematical model to evaluate the benefit of debris flow prevention and control projects.The interpolation method was applied to divide the benefit grades.The debris flow prevention and control projects in Qipan,Taoguan,Chutou,Anjia,and Mozi gullies in Wenchuan County were chosen as typical cases for empirical analysis.The case study revealed that,among the criteria layer indicators,investment per unit of the protected area,investment per unit of the protected population,the amount of water and soil conservation,and reduction rate of accumulation fan had the most significant weights.The social and ecological benefits were found to be the more important in the target layer.The comprehensive benefit of Qipan,Taoguan,Chutou,Anjia,and Mozi gullies was found to be 4.44,4.83,1.95,3,and 2,respectively.The benefit ranking of the five gullies was consistent with their effectiveness in disaster prevention ranking in the flood season of 2019.Therefore,it could prove that the newly-built benefit evaluation model was practical and feasible,and the evaluation results of the sample could be reasonably interpreted,which verified the effectiveness of the methods.展开更多
This paper focuses on the key role and practical paths of operating room nurses in infection control,and studies the difficult problems in the prevention and control of surgical site infections.Analyze the infection r...This paper focuses on the key role and practical paths of operating room nurses in infection control,and studies the difficult problems in the prevention and control of surgical site infections.Analyze the infection risk links in the operating room and the core responsibilities of nurses,reveal the multiple role mechanisms of nurses in infection control,design practical strategies from dimensions such as process optimization,skill improvement,and monitoring feedback,and construct an infection control system involving all staff.Research shows that operating room nurses can effectively reduce the risk of infection,improve medical quality,provide core guarantees for patient safety,and promote the transformation of operating room infection control towards refined management through practical actions such as standardized operation execution,real-time risk monitoring,and team collaboration supervision.展开更多
To further enhance the yield and quality of kiwifruit and promote the sustainable development of the kiwifruit industry,this paper summarized the characteristics,damage sites,and control methods of major kiwifruit dis...To further enhance the yield and quality of kiwifruit and promote the sustainable development of the kiwifruit industry,this paper summarized the characteristics,damage sites,and control methods of major kiwifruit diseases and pests.It pointed out the main issues in current kiwifruit pest and disease management and proposed corresponding solutions.The prevention and control of kiwifruit pests should adhere to the principle of"prevention first,integrated management",and standardized planting modes should be implemented.In this process,priority should be given to agricultural,physical,and biological control methods to effectively reduce the use of chemical pesticides.展开更多
TWith the global acceleration of population aging,the number of patients with Parkinson’s disease(PD)continues to rise,and falls have become one of the main issues affecting their health and quality of life.The risk ...TWith the global acceleration of population aging,the number of patients with Parkinson’s disease(PD)continues to rise,and falls have become one of the main issues affecting their health and quality of life.The risk of falls is significantly increased in PD patients due to multiple factors,including motor symptoms,non-motor symptoms,medication side effects,unsafe environments,and psychological or behavioral factors.Falls can cause severe physical injuries,reduce independence,and trigger psychological problems such as depression and anxiety.In recent years,both domestic and international studies have made progress in identifying fall risk factors,developing risk assessment tools,and implementing multidimensional prevention strategies.Effective preventive measures include high-risk population screening,disease progression monitoring,exercise rehabilitation training,management of non-motor symptoms,medication optimization,environmental safety modifications,and psychological-behavioral interventions.Scientific and systematic comprehensive management can help reduce the incidence of falls among PD patients and improve their quality of life.This review summarizes the latest research advances on the main risk factors and preventive strategies for falls in patients with Parkinson’s disease,providing a theoretical basis and practical guidance for clinical nursing and rehabilitation interventions.展开更多
Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying...Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying high-risk myopia population and formulating effective intervention strategies.Methods:A cross-sectional study was conducted from October to November 2023,enrolling 811 fourth-grade students from three primary schools in three cities across Fujian.Personal information and lifestyle-related pattern were collected using customized questionnaire.Participants underwent comprehensive ophthalmic assessments including distance visual acuity tests and refractive examinations.Logistic regression analysis was used to assess the impact of lifestyle on the onset of myopia.Results:The prevalence of myopia among fourth-grade students in urban primary schools in Fujian was 46.4%.Only 25.8%students engaged in outdoor activities for more than 2 hours daily,while63.3%participated in outdoor activities during class breaks.Multivariate Logistic regression analysis revealed that outdoor activities during class breaks(OR=0.646(95%confidence interval(CI):0.473-0.881),P=0.006)and daily time spent outdoors(2-3 hours,OR=0.682(95%CI:0.466-0.993),P=0.047;more than 3 hours,OR=0.403(95%CI:0.192-0.796),P=0.01)were independent protective factors against myopia.Lifestyle significantly enhanced the predictive performance for myopia(P=0.01).Additionally,parental myopia(one parent with myopia,OR=2.247(95%CI:1.612-3.145),P<0.001;both parents with myopia,OR=4.824(95%CI:3.262-7.204),P<0.001)emerged as a key risk factor for myopia.Conclusions:There is considerable scope for improving the lifestyle of primary school students in urban areas of Fujian.Lifestyle is strongly associated with myopia onset,highlighting the need for schools and families to actively encourage students to engage in more outdoor activities and take breaks outdoors to prevent and control myopia.Students with parents,especially both parents,having myopia should be considered as a key target group for myopia prevention efforts.展开更多
Economically and effectively managing the risk of landslide-generated impulse waves(LGIWs)presents a significant challenge following the impoundment of newly constructed reservoirs in western China.To address this iss...Economically and effectively managing the risk of landslide-generated impulse waves(LGIWs)presents a significant challenge following the impoundment of newly constructed reservoirs in western China.To address this issue,we selected the Wangjiashan(WJS)landslide in the Baihetan Reservoir area as a case study to evaluate LGIW hazards and develop corresponding mitigation strategies.Using 2D physical model tests and 3D numerical simulations,we established a 3D hazard assessment method for LGIWs based on 2D experimental results.This method confirmed the effectiveness of slope-cutting engineering in mitigating LGIW hazards.Based on this assessment framework,we proposed a novel approach for LGIW risk reduction.The results showed that the maximum wave amplitude reached 19.64 m in the Jinsha River channel,and the maximum run-up was 11.5 m in the XiangBiLing(XBL)community,indicating a substantial LGIW threat to the area.By reducing the rear edge of the sliding mass to 920 m above sea level(asl),the LGIW risk to the XBL community could be lowered to a tolerable level.Compared with traditional landslide prevention and control measures,the proposed mitigation scheme can reduce excavation costs by approximately 37 million CNY,making it a more scientifically sound and economically feasible solution.We explored the concept and the implementation of LGIW risk mitigation in depth,offering new insights for global LGIW risk management.This case study enhances our understanding of LGIW hazard prevention and provides valuable guidance for policymaking and engineering practices in similar geological settings worldwide.展开更多
基金Natural Science Foundation of Hubei Province(No.2025AFC041).
文摘China implemented its Action Plan of Air Pollution Prevention and Control(APAPPC)in 2013 as a major step in national air-quality management.This study treated the APAPPC as a quasi-experiment,drawing on the Grossman and Cropper models,to examine how air pollution affected individual health capital and medical service demand.Using panel data from the China Health and Retirement Longitudinal Study for 2011,2013,2015,and 2018,the analysis applied a Heckman two-stage model and difference-in-differences estimation to identify the policy's effects on medical expenditure.The results showed that the APAPPC significantly reduced annual health spending,with stronger effects among women,older adults,and rural residents.The mechanism analysis indicated that the reduction in respiratory diseases played a key role.This study provides evidence that supports further airpollution control in China and offers useful insights for other developing countries.
文摘Rabies is a zoonotic disease with an estimated global mortality of 59,000 people annually and a burden of more than 3.7 million disability-adjusted life years(DALYs)that is caused by a neurotropic lyssavirus[1].Dogs are the primary source of human rabies,as more than 95%of human cases can be traced to dogs[2,3].China faces a substantial burden of rabies,having endured three major human rabies epidemics,which occurred in the 1950s,1981,and 2007[4].Implementation of various prevention and control measures has decreased the number of human rabies cases from 3,300 in 2007 to 167 in 2024.In China.
基金supported by a project entitled Loess Plateau Region-Watershed-Slope Geological Hazard Multi-Scale Collaborative Intelligent Early Warning System of the National Key R&D Program of China(2022YFC3003404)a project of the Shaanxi Youth Science and Technology Star(2021KJXX-87)public welfare geological survey projects of Shaanxi Institute of Geologic Survey(20180301,201918,202103,and 202413)。
文摘This study developed a modeling methodology for statistical optimization-based geologic hazard susceptibility assessment,aiming to enhance the comprehensive performance and classification accuracy of the assessment models.First,the cumulative probability method revealed that a low probability(15%)of geologic hazards between any two geologic hazard points occurred outside a buffer zone with a radius of 2297 m(i.e.,the distance threshold).The training dataset was established,consisting of negative samples(non-hazard points)randomly generated based on the distance threshold,positive samples(i.e.,historical hazards),and 13 conditioning factors.Then,models were built using five machine learning algorithms,namely random forest(RF),gradient boosting decision tree(GBDT),naive Bayes(NB),logistic regression(LR),and support vector machine(SVM).The comprehensive performance of the models was assessed using the area under the receiver operating characteristic curve(AUC)and overall accuracy(OA)as indicators,revealing that RF exhibited the best performance,with OA and AUC values of 2.7127 and 0.981,respectively.Furthermore,the machine learning models constructed by considering the distance threshold outperformed those built using the unoptimized dataset.The characteristic factors were ranked using the mutual information method,with their scores decreasing in the order of rainfall(0.1616),altitude(0.06),normalized difference vegetation index(NDVI;0.04),and distance from roads(0.03).Finally,the geologic hazard susceptibility classification was assessed using the natural breaks method combined with a clustering algorithm.The results indicate that the clustering algorithm exhibited higher classification accuracy than the natural breaks method.The findings of this study demonstrate that the proposed model optimization scheme can provide a scientific basis for the prevention and control of geologic hazards.
文摘To address uncertainty as well as transient stability constraints simultaneously in the preventive control of windfarm systems, a novel three-stage optimization strategy is established in this paper. In the first stage, the probabilisticmulti-objective particle swarm optimization based on the point estimate method is employed to cope with thestochastic factors. The transient security region of the system is accurately ensured by the interior point methodin the second stage. Finally, the verification of the final optimal objectives and satisfied constraints are enforcedin the last stage. Furthermore, the proposed strategy is a general framework that can combine other optimizationalgorithms. The proposed methodology is tested on the modified WSCC 9-bus system and the New England 39-bussystem. The results verify the feasibility of the method.
文摘Water supply and drainage engineering is a key project in infrastructure construction, and various pipes, appliances and construction quality control are the key monitoring contents in water supply and drainage engineering. In the face of people's increasing demand for water, the anti leakage problem in water supply and drainage engineering is more prominent. In order to solve the most concerned problems and improve the safety of water supply and drainage system, design, implementation and material use are very important for anti leakage treatment and prevention.
文摘The construction enterprise tax risk as the breakthrough point, focus from existing obligations to pay taxes but did not declare and pay VAT, payment of accounts receivable in time after discount but did not open the scarlet letter, engaged in ACTS related to invoices not accounted for separately, the issue VAT invoices, do not conform to the requirements of the specification of four aspects of building enterprise tax risk management assessment and prevention countermeasures.
文摘This letter evaluates Shahid et al’s study in 2025 on the rising hepatitis A virus(HAV)among adults in Pakistan,highlighting a shift in the virus’s epidemiology.Once primarily a childhood disease in low-income regions,HAV is now increasingly affecting adults,also seen globally due to improved sanitation.The study highlights public health challenges from adult HAV infections,which can lead to complications like coagulopathy and acute liver failure.It also has limitations,including being a single-center study and lacking seroprevalence and socioeconomic data,indicating the need for further research.This letter calls for urgent public health measures to extend adult vaccination programs and improve sanitation to address the increasing HAV infection in adult populations.
文摘With the implementation of significant national strategies and rapid socioeconomic development,many ultra-long deep tunnels are being constructed in the Qinghai–Xizang Plateau region.However,the extreme complexity and variability of the environment in this region pose significant challenges to the safe construction and long-term operation of the planned or under-construction ultra-long deep tunnels.To address these complex technical challenges,this paper provides a detailed analysis of the complex climate and geology features of the Qinghai–Xizang Plateau during tunnel construction.The climate characteristics of the Qinghai–Xizang Plateau include severe coldness,low oxygen,and unpredictable weather changes.The geological characteristics include complex stress distributions caused by the intense internal and external dynamic coupling of tectonic plates,widespread active tectonic structures,frequent high-intensity earthquakes,fractured rock masses,and numerous active fault zones.Based on the analysis,this paper elaborates on potential sources of major disasters resulting from the characteristics of ultra-long deep tunnel projects in the Qinghai–Xizang Plateau region.These potential disaster sources include the crossing of active fault zones,high geostress rockbursts,large deformation disasters,high-pressure water surges,geothermal hazards,inadequate long-distance ventilation and oxygen supply,and multi-hazard couplings.In response to these challenges,this paper systematically summarizes the latest research progress and technological achievements in the domestic and international literature,and proposes innovative ideas and future development prospects for disaster monitoring and early warning,mechanized intelligent construction,long-term safety services,and emergency security and rescue.These innovative measures are intended to address the challenges of tunnel disaster prevention and control in the complex environment of the Qinghai–Xizang Plateau,contributing to the safe construction and long-term operation of ultra-long deep tunnels in this region.
基金supported by the Natural Science Foundation of Henan Province(242300421246)the National Natural Science Foundation of China(52004082,U24B2041,52174073,52274079)+2 种基金the Key Research and Development Program of Henan Province(251111320400)the Program for Science&Technology Innovation Talents in Universities of Henan Province(24HASTIT021)the Program for the Scientific and Technological Innovation Team in Universities of Henan Province(23IRTSTHN005).
文摘With the depletion of shallow mineral resources,mining operations are extending to greater depths and larger scales,increasing the risk of water inrush disasters,particularly from confined aquifers intersected by faults.This paper reviews the current state of research on fault-induced water inrushes in mining faces,examining the damage characteristics and permeability of fractured floor rock,the mechanical behavior of faults under mining stress,and the mechanisms driving water inrush.Advances in prevention technologies,risk assessment,and prediction methods are also summarized.Research shows that damage evolution in fractured floor rock,coupled with fluid-solid interactions,provides the primary pathways for water inrush.Stress-seepage coupling in porous media plays a decisive role in determining inrush potential.Mining-induced stress redistribution can activate faults,with parameters such as dip angle and internal friction angle controlling stress evolution and slip.Critical triggers include the hydraulic connectivity among faults,aquifers,and mining-induced fracture networks,followed by hydraulic erosion.A multi-pronged prevention framework has been developed,integrating precise fault detection,targeted grouting for water sealing,drainage to reduce water pressure,optimized waterproof coal pillar design,and dynamic risk assessment and prediction.However,gaps remain in understanding multi-physical field coupling under deep mining conditions,establishing quantitative criteria for fault activation-induced water inrush,and refining control technologies.Future work should focus on multi-scale numerical simulations,advanced active control measures,and intelligent,integrated prevention systems to clarify the mechanisms of fault-induced water inrush and enhance theoretical and technical support for mine safety.
文摘As a major global public health issue,tuberculosis is closely related to multiple socio-ecological factors in its epidemiological patterns~([1]).China,as a high-burden country for tuberculosis,exhibits regional variations in the distribution of the tuberculosis epidemic.To enhance the efficiency of prevention and control,its strategies are undergoing a transition toward regionally differentiated approaches~([2]).
文摘With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key functional molecules,has shown great potential in the field of disease prevention and control[1,2].The multi-continental transcriptomics study of tick-borne poxvirus not only provides a new perspective for understanding the evolution and transmission of vector-mediated viruses,but also reflects the trend of transcriptomics research and highlights its key role in disease prevention and control[3].
基金supported by funding from the National Natural Science Foundation of China(32072191)Special Funds for Guiding Local Scientific and Technological Development by the Central Government(Guike ZY22096025)。
文摘Probiotics show anti-influenza activity,offering a potential variant-resistant alternative for infection prevention and control.In this study,we evaluated whether a specially formulated yogurt enriched with synbiotics(named yogurt 1)with 7 probiotics and 6 prebiotics,has anti-influenza effects and its underlying mechanisms using a mouse model challenged with influenza virus H1N1 PR8 strain.The mice were treated with phosphate-buffered saline(negative control),yogurt matrix,yogurt 1,and oseltamivir(positive control),respectively.Yogurt 1 treatment improved the survival of infected mice(from 0%to 30%),alleviated pathological injuries in the lungs and colon,and reduced the viral load of influenza virus on day 3 and day 7 post-infection.Yogurt 1 also downregulated some inflammation-related signaling pathways and reduced the levels of proinflammatory cytokines or chemokines in the lungs or serum,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α(TNF-α)and keratinocyte chemoattractant(KC).The levels of short-chain fatty acids in the cecal content were increased,the diversity of the intestinal flora was partially restored,and influenza-specific Ig G and interferon-secreting lymphocytes were enhanced following yogurt 1 administration.Thus,yogurt 1,as a commercial and easily accessible dairy product,demonstrated a notable anti-influenza effect in mice by inhibiting viral proliferation,suppressing excessive inflammatory responses,and promoting influenza virus-specific adaptive humoral and cellular immune responses,demonstrating its potential for influenza epidemic prevention and control.
文摘BACKGROUND Colorectal cancer has a high incidence and mortality rate,and the effectiveness of routine colonoscopy largely depends on the endoscopist’s expertise.In recent years,computer-aided detection(CADe)systems have been increasingly integrated into colonoscopy to improve detection accuracy.However,while most studies have focused on adenoma detection rate(ADR)as the primary outcome,the more sensitive adenoma miss rate(AMR)has been less frequently analyzed.AIM To evaluate the effectiveness of CADe in colonoscopy and assess the advantages of AMR over ADR.METHODS A comprehensive literature search was conducted in PubMed,Embase,and the Cochrane Central Register of Controlled Trials using predefined search strategies to identify relevant studies published up to August 2,2024.Statistical analyses were performed to compare outcomes between groups,and potential publication bias was assessed using funnel plots.The quality of the included studies was evaluated using the Cochrane Risk of Bias tool and the Grading of Recommendations,Assessment,Development,and Evaluation approach.RESULTS Five studies comprising 1624 patients met the inclusion criteria.AMR was significantly lower in the CADe-assisted group than in the routine colonoscopy group(147/927,15.9%vs 345/960,35.9%;P<0.01).However,CADe did not provide a significant advantage in detecting advanced adenomas or lesions measuring 6-9 mm or≥10 mm.The polyp miss rate(PMR)was also lower in the CADe-assisted group[odds ratio(OR),0.35;95% confidence interval(CI):0.23-0.52;P<0.01].While the overall ADR did not differ significantly between groups,the ADR during the first-pass examination was higher in the CADe-assisted group(OR,1.37;95%CI:1.10-1.69;P=0.004).The level of evidence for the included randomized controlled trials was graded as moderate.CONCLUSION CADe can significantly reduce AMR and PMR while improving ADR during initial detection,demonstrating its potential to enhance colonoscopy performance.These findings highlight the value of CADe in improving the detection of colorectal neoplasms,particularly small and histologically distinct adenomas.
基金supported by the earmarked fund for National Natural Science Foundation of China(32230105)the China Agriculture Research System(CARS-41)the National Major Agricultural Science and Technology Projects,China(NK2022100103)。
文摘Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV)in poultry.ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K).Among them,ALV-J was first introduced into China in 1999,spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens.ALV-J typically induces myeloid leukosis in infected chickens,but also induces a high proportion of hemangiomas in infected layer chickens,posing a serious threat to poultry breeds in China.As a retrovirus,the genome of ALV-J has undergone significant mutations,which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J.Over the last two decades,the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry.Specialized detection assays have been developed to combat ALV-J infections in China.Additionally,ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections.This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.
基金financially supported by the National Key Research and Development Program(No.2018YFC1505402)the National Natural Science Foundation of China(No.41871174)+1 种基金the Science and Technology Department of Sichuan Province(No.2020YFSY0013)the Fundamental Research Funds for the Central Universities Project(No.2682019CX19)。
文摘Benefit evaluation of debris flow prevention and control projects was one of the essential contents of debris flow prevention and mitigation work.In order to scientifically and quantitatively evaluate the comprehensive benefit of debris flow prevention and control projects,this study identified nine factors as evaluation indicators from economic,social,and ecological aspects.The projection pursuit(PP) model based on the improved particle swarm optimization(IPSO) algorithm was used to construct a mathematical model to evaluate the benefit of debris flow prevention and control projects.The interpolation method was applied to divide the benefit grades.The debris flow prevention and control projects in Qipan,Taoguan,Chutou,Anjia,and Mozi gullies in Wenchuan County were chosen as typical cases for empirical analysis.The case study revealed that,among the criteria layer indicators,investment per unit of the protected area,investment per unit of the protected population,the amount of water and soil conservation,and reduction rate of accumulation fan had the most significant weights.The social and ecological benefits were found to be the more important in the target layer.The comprehensive benefit of Qipan,Taoguan,Chutou,Anjia,and Mozi gullies was found to be 4.44,4.83,1.95,3,and 2,respectively.The benefit ranking of the five gullies was consistent with their effectiveness in disaster prevention ranking in the flood season of 2019.Therefore,it could prove that the newly-built benefit evaluation model was practical and feasible,and the evaluation results of the sample could be reasonably interpreted,which verified the effectiveness of the methods.
文摘This paper focuses on the key role and practical paths of operating room nurses in infection control,and studies the difficult problems in the prevention and control of surgical site infections.Analyze the infection risk links in the operating room and the core responsibilities of nurses,reveal the multiple role mechanisms of nurses in infection control,design practical strategies from dimensions such as process optimization,skill improvement,and monitoring feedback,and construct an infection control system involving all staff.Research shows that operating room nurses can effectively reduce the risk of infection,improve medical quality,provide core guarantees for patient safety,and promote the transformation of operating room infection control towards refined management through practical actions such as standardized operation execution,real-time risk monitoring,and team collaboration supervision.
基金Supported by College-level Scientific Research Project of Guizhou Industry Polytechnic College(2023ZK112023ZK10)Scientific and Technological Innovation Team Project of Guizhou Industry Polytechnic College(2023CXTD03).
文摘To further enhance the yield and quality of kiwifruit and promote the sustainable development of the kiwifruit industry,this paper summarized the characteristics,damage sites,and control methods of major kiwifruit diseases and pests.It pointed out the main issues in current kiwifruit pest and disease management and proposed corresponding solutions.The prevention and control of kiwifruit pests should adhere to the principle of"prevention first,integrated management",and standardized planting modes should be implemented.In this process,priority should be given to agricultural,physical,and biological control methods to effectively reduce the use of chemical pesticides.
文摘TWith the global acceleration of population aging,the number of patients with Parkinson’s disease(PD)continues to rise,and falls have become one of the main issues affecting their health and quality of life.The risk of falls is significantly increased in PD patients due to multiple factors,including motor symptoms,non-motor symptoms,medication side effects,unsafe environments,and psychological or behavioral factors.Falls can cause severe physical injuries,reduce independence,and trigger psychological problems such as depression and anxiety.In recent years,both domestic and international studies have made progress in identifying fall risk factors,developing risk assessment tools,and implementing multidimensional prevention strategies.Effective preventive measures include high-risk population screening,disease progression monitoring,exercise rehabilitation training,management of non-motor symptoms,medication optimization,environmental safety modifications,and psychological-behavioral interventions.Scientific and systematic comprehensive management can help reduce the incidence of falls among PD patients and improve their quality of life.This review summarizes the latest research advances on the main risk factors and preventive strategies for falls in patients with Parkinson’s disease,providing a theoretical basis and practical guidance for clinical nursing and rehabilitation interventions.
基金supported by the Science and Technology Planning Project of Guangdong Province(2023A1111120011)the Natural Science Foundation of Guangdong Province(2024A1515010801).
文摘Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying high-risk myopia population and formulating effective intervention strategies.Methods:A cross-sectional study was conducted from October to November 2023,enrolling 811 fourth-grade students from three primary schools in three cities across Fujian.Personal information and lifestyle-related pattern were collected using customized questionnaire.Participants underwent comprehensive ophthalmic assessments including distance visual acuity tests and refractive examinations.Logistic regression analysis was used to assess the impact of lifestyle on the onset of myopia.Results:The prevalence of myopia among fourth-grade students in urban primary schools in Fujian was 46.4%.Only 25.8%students engaged in outdoor activities for more than 2 hours daily,while63.3%participated in outdoor activities during class breaks.Multivariate Logistic regression analysis revealed that outdoor activities during class breaks(OR=0.646(95%confidence interval(CI):0.473-0.881),P=0.006)and daily time spent outdoors(2-3 hours,OR=0.682(95%CI:0.466-0.993),P=0.047;more than 3 hours,OR=0.403(95%CI:0.192-0.796),P=0.01)were independent protective factors against myopia.Lifestyle significantly enhanced the predictive performance for myopia(P=0.01).Additionally,parental myopia(one parent with myopia,OR=2.247(95%CI:1.612-3.145),P<0.001;both parents with myopia,OR=4.824(95%CI:3.262-7.204),P<0.001)emerged as a key risk factor for myopia.Conclusions:There is considerable scope for improving the lifestyle of primary school students in urban areas of Fujian.Lifestyle is strongly associated with myopia onset,highlighting the need for schools and families to actively encourage students to engage in more outdoor activities and take breaks outdoors to prevent and control myopia.Students with parents,especially both parents,having myopia should be considered as a key target group for myopia prevention efforts.
基金supported by the National Natural Science Foundation of China(No.U23A2045)the China Three Gorges Corporation(YM(BHT)/(22)022).
文摘Economically and effectively managing the risk of landslide-generated impulse waves(LGIWs)presents a significant challenge following the impoundment of newly constructed reservoirs in western China.To address this issue,we selected the Wangjiashan(WJS)landslide in the Baihetan Reservoir area as a case study to evaluate LGIW hazards and develop corresponding mitigation strategies.Using 2D physical model tests and 3D numerical simulations,we established a 3D hazard assessment method for LGIWs based on 2D experimental results.This method confirmed the effectiveness of slope-cutting engineering in mitigating LGIW hazards.Based on this assessment framework,we proposed a novel approach for LGIW risk reduction.The results showed that the maximum wave amplitude reached 19.64 m in the Jinsha River channel,and the maximum run-up was 11.5 m in the XiangBiLing(XBL)community,indicating a substantial LGIW threat to the area.By reducing the rear edge of the sliding mass to 920 m above sea level(asl),the LGIW risk to the XBL community could be lowered to a tolerable level.Compared with traditional landslide prevention and control measures,the proposed mitigation scheme can reduce excavation costs by approximately 37 million CNY,making it a more scientifically sound and economically feasible solution.We explored the concept and the implementation of LGIW risk mitigation in depth,offering new insights for global LGIW risk management.This case study enhances our understanding of LGIW hazard prevention and provides valuable guidance for policymaking and engineering practices in similar geological settings worldwide.
