To address uncertainty as well as transient stability constraints simultaneously in the preventive control of windfarm systems, a novel three-stage optimization strategy is established in this paper. In the first stag...To address uncertainty as well as transient stability constraints simultaneously in the preventive control of windfarm systems, a novel three-stage optimization strategy is established in this paper. In the first stage, the probabilisticmulti-objective particle swarm optimization based on the point estimate method is employed to cope with thestochastic factors. The transient security region of the system is accurately ensured by the interior point methodin the second stage. Finally, the verification of the final optimal objectives and satisfied constraints are enforcedin the last stage. Furthermore, the proposed strategy is a general framework that can combine other optimizationalgorithms. The proposed methodology is tested on the modified WSCC 9-bus system and the New England 39-bussystem. The results verify the feasibility of the method.展开更多
As a major global public health issue,tuberculosis is closely related to multiple socio-ecological factors in its epidemiological patterns~([1]).China,as a high-burden country for tuberculosis,exhibits regional variat...As a major global public health issue,tuberculosis is closely related to multiple socio-ecological factors in its epidemiological patterns~([1]).China,as a high-burden country for tuberculosis,exhibits regional variations in the distribution of the tuberculosis epidemic.To enhance the efficiency of prevention and control,its strategies are undergoing a transition toward regionally differentiated approaches~([2]).展开更多
With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key...With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key functional molecules,has shown great potential in the field of disease prevention and control[1,2].The multi-continental transcriptomics study of tick-borne poxvirus not only provides a new perspective for understanding the evolution and transmission of vector-mediated viruses,but also reflects the trend of transcriptomics research and highlights its key role in disease prevention and control[3].展开更多
This letter evaluates Shahid et al’s study in 2025 on the rising hepatitis A virus(HAV)among adults in Pakistan,highlighting a shift in the virus’s epidemiology.Once primarily a childhood disease in low-income regio...This letter evaluates Shahid et al’s study in 2025 on the rising hepatitis A virus(HAV)among adults in Pakistan,highlighting a shift in the virus’s epidemiology.Once primarily a childhood disease in low-income regions,HAV is now increasingly affecting adults,also seen globally due to improved sanitation.The study highlights public health challenges from adult HAV infections,which can lead to complications like coagulopathy and acute liver failure.It also has limitations,including being a single-center study and lacking seroprevalence and socioeconomic data,indicating the need for further research.This letter calls for urgent public health measures to extend adult vaccination programs and improve sanitation to address the increasing HAV infection in adult populations.展开更多
Probiotics show anti-influenza activity,offering a potential variant-resistant alternative for infection prevention and control.In this study,we evaluated whether a specially formulated yogurt enriched with synbiotics...Probiotics show anti-influenza activity,offering a potential variant-resistant alternative for infection prevention and control.In this study,we evaluated whether a specially formulated yogurt enriched with synbiotics(named yogurt 1)with 7 probiotics and 6 prebiotics,has anti-influenza effects and its underlying mechanisms using a mouse model challenged with influenza virus H1N1 PR8 strain.The mice were treated with phosphate-buffered saline(negative control),yogurt matrix,yogurt 1,and oseltamivir(positive control),respectively.Yogurt 1 treatment improved the survival of infected mice(from 0%to 30%),alleviated pathological injuries in the lungs and colon,and reduced the viral load of influenza virus on day 3 and day 7 post-infection.Yogurt 1 also downregulated some inflammation-related signaling pathways and reduced the levels of proinflammatory cytokines or chemokines in the lungs or serum,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α(TNF-α)and keratinocyte chemoattractant(KC).The levels of short-chain fatty acids in the cecal content were increased,the diversity of the intestinal flora was partially restored,and influenza-specific Ig G and interferon-secreting lymphocytes were enhanced following yogurt 1 administration.Thus,yogurt 1,as a commercial and easily accessible dairy product,demonstrated a notable anti-influenza effect in mice by inhibiting viral proliferation,suppressing excessive inflammatory responses,and promoting influenza virus-specific adaptive humoral and cellular immune responses,demonstrating its potential for influenza epidemic prevention and control.展开更多
BACKGROUND Colorectal cancer has a high incidence and mortality rate,and the effectiveness of routine colonoscopy largely depends on the endoscopist’s expertise.In recent years,computer-aided detection(CADe)systems h...BACKGROUND Colorectal cancer has a high incidence and mortality rate,and the effectiveness of routine colonoscopy largely depends on the endoscopist’s expertise.In recent years,computer-aided detection(CADe)systems have been increasingly integrated into colonoscopy to improve detection accuracy.However,while most studies have focused on adenoma detection rate(ADR)as the primary outcome,the more sensitive adenoma miss rate(AMR)has been less frequently analyzed.AIM To evaluate the effectiveness of CADe in colonoscopy and assess the advantages of AMR over ADR.METHODS A comprehensive literature search was conducted in PubMed,Embase,and the Cochrane Central Register of Controlled Trials using predefined search strategies to identify relevant studies published up to August 2,2024.Statistical analyses were performed to compare outcomes between groups,and potential publication bias was assessed using funnel plots.The quality of the included studies was evaluated using the Cochrane Risk of Bias tool and the Grading of Recommendations,Assessment,Development,and Evaluation approach.RESULTS Five studies comprising 1624 patients met the inclusion criteria.AMR was significantly lower in the CADe-assisted group than in the routine colonoscopy group(147/927,15.9%vs 345/960,35.9%;P<0.01).However,CADe did not provide a significant advantage in detecting advanced adenomas or lesions measuring 6-9 mm or≥10 mm.The polyp miss rate(PMR)was also lower in the CADe-assisted group[odds ratio(OR),0.35;95% confidence interval(CI):0.23-0.52;P<0.01].While the overall ADR did not differ significantly between groups,the ADR during the first-pass examination was higher in the CADe-assisted group(OR,1.37;95%CI:1.10-1.69;P=0.004).The level of evidence for the included randomized controlled trials was graded as moderate.CONCLUSION CADe can significantly reduce AMR and PMR while improving ADR during initial detection,demonstrating its potential to enhance colonoscopy performance.These findings highlight the value of CADe in improving the detection of colorectal neoplasms,particularly small and histologically distinct adenomas.展开更多
Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV)in poultry.ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K).Among them,ALV-J was first...Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV)in poultry.ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K).Among them,ALV-J was first introduced into China in 1999,spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens.ALV-J typically induces myeloid leukosis in infected chickens,but also induces a high proportion of hemangiomas in infected layer chickens,posing a serious threat to poultry breeds in China.As a retrovirus,the genome of ALV-J has undergone significant mutations,which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J.Over the last two decades,the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry.Specialized detection assays have been developed to combat ALV-J infections in China.Additionally,ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections.This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.展开更多
With the implementation of significant national strategies and rapid socioeconomic development,many ultra-long deep tunnels are being constructed in the Qinghai–Xizang Plateau region.However,the extreme complexity an...With the implementation of significant national strategies and rapid socioeconomic development,many ultra-long deep tunnels are being constructed in the Qinghai–Xizang Plateau region.However,the extreme complexity and variability of the environment in this region pose significant challenges to the safe construction and long-term operation of the planned or under-construction ultra-long deep tunnels.To address these complex technical challenges,this paper provides a detailed analysis of the complex climate and geology features of the Qinghai–Xizang Plateau during tunnel construction.The climate characteristics of the Qinghai–Xizang Plateau include severe coldness,low oxygen,and unpredictable weather changes.The geological characteristics include complex stress distributions caused by the intense internal and external dynamic coupling of tectonic plates,widespread active tectonic structures,frequent high-intensity earthquakes,fractured rock masses,and numerous active fault zones.Based on the analysis,this paper elaborates on potential sources of major disasters resulting from the characteristics of ultra-long deep tunnel projects in the Qinghai–Xizang Plateau region.These potential disaster sources include the crossing of active fault zones,high geostress rockbursts,large deformation disasters,high-pressure water surges,geothermal hazards,inadequate long-distance ventilation and oxygen supply,and multi-hazard couplings.In response to these challenges,this paper systematically summarizes the latest research progress and technological achievements in the domestic and international literature,and proposes innovative ideas and future development prospects for disaster monitoring and early warning,mechanized intelligent construction,long-term safety services,and emergency security and rescue.These innovative measures are intended to address the challenges of tunnel disaster prevention and control in the complex environment of the Qinghai–Xizang Plateau,contributing to the safe construction and long-term operation of ultra-long deep tunnels in this region.展开更多
Benefit evaluation of debris flow prevention and control projects was one of the essential contents of debris flow prevention and mitigation work.In order to scientifically and quantitatively evaluate the comprehensiv...Benefit evaluation of debris flow prevention and control projects was one of the essential contents of debris flow prevention and mitigation work.In order to scientifically and quantitatively evaluate the comprehensive benefit of debris flow prevention and control projects,this study identified nine factors as evaluation indicators from economic,social,and ecological aspects.The projection pursuit(PP) model based on the improved particle swarm optimization(IPSO) algorithm was used to construct a mathematical model to evaluate the benefit of debris flow prevention and control projects.The interpolation method was applied to divide the benefit grades.The debris flow prevention and control projects in Qipan,Taoguan,Chutou,Anjia,and Mozi gullies in Wenchuan County were chosen as typical cases for empirical analysis.The case study revealed that,among the criteria layer indicators,investment per unit of the protected area,investment per unit of the protected population,the amount of water and soil conservation,and reduction rate of accumulation fan had the most significant weights.The social and ecological benefits were found to be the more important in the target layer.The comprehensive benefit of Qipan,Taoguan,Chutou,Anjia,and Mozi gullies was found to be 4.44,4.83,1.95,3,and 2,respectively.The benefit ranking of the five gullies was consistent with their effectiveness in disaster prevention ranking in the flood season of 2019.Therefore,it could prove that the newly-built benefit evaluation model was practical and feasible,and the evaluation results of the sample could be reasonably interpreted,which verified the effectiveness of the methods.展开更多
This paper focuses on the key role and practical paths of operating room nurses in infection control,and studies the difficult problems in the prevention and control of surgical site infections.Analyze the infection r...This paper focuses on the key role and practical paths of operating room nurses in infection control,and studies the difficult problems in the prevention and control of surgical site infections.Analyze the infection risk links in the operating room and the core responsibilities of nurses,reveal the multiple role mechanisms of nurses in infection control,design practical strategies from dimensions such as process optimization,skill improvement,and monitoring feedback,and construct an infection control system involving all staff.Research shows that operating room nurses can effectively reduce the risk of infection,improve medical quality,provide core guarantees for patient safety,and promote the transformation of operating room infection control towards refined management through practical actions such as standardized operation execution,real-time risk monitoring,and team collaboration supervision.展开更多
With the depletion of shallow mineral resources,mining operations are extending to greater depths and larger scales,increasing the risk of water inrush disasters,particularly from confined aquifers intersected by faul...With the depletion of shallow mineral resources,mining operations are extending to greater depths and larger scales,increasing the risk of water inrush disasters,particularly from confined aquifers intersected by faults.This paper reviews the current state of research on fault-induced water inrushes in mining faces,examining the damage characteristics and permeability of fractured floor rock,the mechanical behavior of faults under mining stress,and the mechanisms driving water inrush.Advances in prevention technologies,risk assessment,and prediction methods are also summarized.Research shows that damage evolution in fractured floor rock,coupled with fluid-solid interactions,provides the primary pathways for water inrush.Stress-seepage coupling in porous media plays a decisive role in determining inrush potential.Mining-induced stress redistribution can activate faults,with parameters such as dip angle and internal friction angle controlling stress evolution and slip.Critical triggers include the hydraulic connectivity among faults,aquifers,and mining-induced fracture networks,followed by hydraulic erosion.A multi-pronged prevention framework has been developed,integrating precise fault detection,targeted grouting for water sealing,drainage to reduce water pressure,optimized waterproof coal pillar design,and dynamic risk assessment and prediction.However,gaps remain in understanding multi-physical field coupling under deep mining conditions,establishing quantitative criteria for fault activation-induced water inrush,and refining control technologies.Future work should focus on multi-scale numerical simulations,advanced active control measures,and intelligent,integrated prevention systems to clarify the mechanisms of fault-induced water inrush and enhance theoretical and technical support for mine safety.展开更多
To further enhance the yield and quality of kiwifruit and promote the sustainable development of the kiwifruit industry,this paper summarized the characteristics,damage sites,and control methods of major kiwifruit dis...To further enhance the yield and quality of kiwifruit and promote the sustainable development of the kiwifruit industry,this paper summarized the characteristics,damage sites,and control methods of major kiwifruit diseases and pests.It pointed out the main issues in current kiwifruit pest and disease management and proposed corresponding solutions.The prevention and control of kiwifruit pests should adhere to the principle of"prevention first,integrated management",and standardized planting modes should be implemented.In this process,priority should be given to agricultural,physical,and biological control methods to effectively reduce the use of chemical pesticides.展开更多
Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying...Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying high-risk myopia population and formulating effective intervention strategies.Methods:A cross-sectional study was conducted from October to November 2023,enrolling 811 fourth-grade students from three primary schools in three cities across Fujian.Personal information and lifestyle-related pattern were collected using customized questionnaire.Participants underwent comprehensive ophthalmic assessments including distance visual acuity tests and refractive examinations.Logistic regression analysis was used to assess the impact of lifestyle on the onset of myopia.Results:The prevalence of myopia among fourth-grade students in urban primary schools in Fujian was 46.4%.Only 25.8%students engaged in outdoor activities for more than 2 hours daily,while63.3%participated in outdoor activities during class breaks.Multivariate Logistic regression analysis revealed that outdoor activities during class breaks(OR=0.646(95%confidence interval(CI):0.473-0.881),P=0.006)and daily time spent outdoors(2-3 hours,OR=0.682(95%CI:0.466-0.993),P=0.047;more than 3 hours,OR=0.403(95%CI:0.192-0.796),P=0.01)were independent protective factors against myopia.Lifestyle significantly enhanced the predictive performance for myopia(P=0.01).Additionally,parental myopia(one parent with myopia,OR=2.247(95%CI:1.612-3.145),P<0.001;both parents with myopia,OR=4.824(95%CI:3.262-7.204),P<0.001)emerged as a key risk factor for myopia.Conclusions:There is considerable scope for improving the lifestyle of primary school students in urban areas of Fujian.Lifestyle is strongly associated with myopia onset,highlighting the need for schools and families to actively encourage students to engage in more outdoor activities and take breaks outdoors to prevent and control myopia.Students with parents,especially both parents,having myopia should be considered as a key target group for myopia prevention efforts.展开更多
Economically and effectively managing the risk of landslide-generated impulse waves(LGIWs)presents a significant challenge following the impoundment of newly constructed reservoirs in western China.To address this iss...Economically and effectively managing the risk of landslide-generated impulse waves(LGIWs)presents a significant challenge following the impoundment of newly constructed reservoirs in western China.To address this issue,we selected the Wangjiashan(WJS)landslide in the Baihetan Reservoir area as a case study to evaluate LGIW hazards and develop corresponding mitigation strategies.Using 2D physical model tests and 3D numerical simulations,we established a 3D hazard assessment method for LGIWs based on 2D experimental results.This method confirmed the effectiveness of slope-cutting engineering in mitigating LGIW hazards.Based on this assessment framework,we proposed a novel approach for LGIW risk reduction.The results showed that the maximum wave amplitude reached 19.64 m in the Jinsha River channel,and the maximum run-up was 11.5 m in the XiangBiLing(XBL)community,indicating a substantial LGIW threat to the area.By reducing the rear edge of the sliding mass to 920 m above sea level(asl),the LGIW risk to the XBL community could be lowered to a tolerable level.Compared with traditional landslide prevention and control measures,the proposed mitigation scheme can reduce excavation costs by approximately 37 million CNY,making it a more scientifically sound and economically feasible solution.We explored the concept and the implementation of LGIW risk mitigation in depth,offering new insights for global LGIW risk management.This case study enhances our understanding of LGIW hazard prevention and provides valuable guidance for policymaking and engineering practices in similar geological settings worldwide.展开更多
As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utili...As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.展开更多
In this study, RT-PCR was performed on lung tissue samples from sick pigs in a suspected outbreak of porcine reproductive and respiratory syndrome (PRRS) at a pig farm in Mianyang City, Sichuan Province, China. Positi...In this study, RT-PCR was performed on lung tissue samples from sick pigs in a suspected outbreak of porcine reproductive and respiratory syndrome (PRRS) at a pig farm in Mianyang City, Sichuan Province, China. Positive samples were inoculated into Marc-145 cells to observe lesions. The Marc-145 cells with cytopathic lesions were identified by indirect immunofluorescence. The whole genome sequences of the isolated and purified strains were amplified by RT-PCR and analyzed for homology and genetic evolution. A strain of porcine reproductive and respiratory syndrome virus (PRRSV), named SCMY2023 (GenBank No. PQ179742), was successfully isolated. SCMY2023 has a genome length of 15,321 base pairs (without a poly A tail). Nucleotide and amino acid homology analyses suggest that this strain belongs to Lineage 8, a variant of the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) prevalent in China. Recombination and genetic evolution analyses indicate that this isolate is a PRRSV variant that recombined with HuN-ZZ (Lineage 8, 98.79% homology) on the backbone of the SCSN2020 strain (Lineage 8, 99.35% homology) in the recombination region from 4407 to 13,107 nucleotides (ORF1a to ORF3). In-depth study of the genetic recombination of this isolate can provide a reference for the prevention and control of PRRS.展开更多
Acquired Immunodeficiency Syndrome(AIDS)caused by Human Immunodeficiency Virus(HIV)infection poses a serious threat to global public health.This article comprehensively reviews the epidemiological characteristics of H...Acquired Immunodeficiency Syndrome(AIDS)caused by Human Immunodeficiency Virus(HIV)infection poses a serious threat to global public health.This article comprehensively reviews the epidemiological characteristics of HIV infection,including the global and domestic epidemic situation,transmission routes,and characteristics of high-risk groups.It also introduces comprehensive prevention and control strategies in detail.Through analysis,it aims to provide a reference for further optimizing HIV prevention and control work.展开更多
This article aims to enhance seismic hazard assessment methods for Kazakhstan’s seismotectonic conditions.It combines probabilistic seismic hazard analysis(PSHA),ground motion simulation,sitespecific geological and g...This article aims to enhance seismic hazard assessment methods for Kazakhstan’s seismotectonic conditions.It combines probabilistic seismic hazard analysis(PSHA),ground motion simulation,sitespecific geological and geotechnical data analysis,and seismic scenario analysis to develop Probabilistic General Seismic Zoning(GSZ)maps for Kazakhstan and Probabilistic Seismic Microzoning maps for Almaty.These maps align with Eurocode 8 principles,incorporating seismic intensity and engineering parameters like peak ground acceleration(PGA).The new procedure,applied in national projects,has resulted in GSZ maps for the country,seismic microzoning maps for Almaty,and detailed seismic zoning maps for East Kazakhstan.These maps,part of a regulatory document,guide earthquake-resistant design and construction.They offer a comprehensive assessment of seismic hazards,integrating traditional Medvedev-Sponheuer-Karnik(MSK-64)intensity scale points with quantitative parameters like peak ground acceleration.This innovative approach promises to advance methods for quantifying seismic hazards in specific regions.展开更多
High-end club decoration projects require the integration of multifunctional spaces,high-precision craftsmanship,and eco-friendly material applications.Their complexity necessitates the construction of a closed-loop m...High-end club decoration projects require the integration of multifunctional spaces,high-precision craftsmanship,and eco-friendly material applications.Their complexity necessitates the construction of a closed-loop management system across the entire process,utilizing BIM technology for design optimization,blockchain for material traceability,and Monte Carlo simulations for risk quantification.AI visual inspection and dynamic risk assessment models enable precise identification of process defects and safety hazards,while standardized craftsmanship,intelligent monitoring,and optimized emergency plans ensure engineering quality and safety.The integration of low-carbon material innovation and intelligent technologies drives the industry toward efficient,green,and sustainable development,offering systematic solutions for high-end decoration projects.展开更多
This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analys...This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analysis revealed ten significant issues related to HIV risk behaviors among university students, leading to suggested intervention strategies to address these behaviors.展开更多
文摘To address uncertainty as well as transient stability constraints simultaneously in the preventive control of windfarm systems, a novel three-stage optimization strategy is established in this paper. In the first stage, the probabilisticmulti-objective particle swarm optimization based on the point estimate method is employed to cope with thestochastic factors. The transient security region of the system is accurately ensured by the interior point methodin the second stage. Finally, the verification of the final optimal objectives and satisfied constraints are enforcedin the last stage. Furthermore, the proposed strategy is a general framework that can combine other optimizationalgorithms. The proposed methodology is tested on the modified WSCC 9-bus system and the New England 39-bussystem. The results verify the feasibility of the method.
文摘As a major global public health issue,tuberculosis is closely related to multiple socio-ecological factors in its epidemiological patterns~([1]).China,as a high-burden country for tuberculosis,exhibits regional variations in the distribution of the tuberculosis epidemic.To enhance the efficiency of prevention and control,its strategies are undergoing a transition toward regionally differentiated approaches~([2]).
文摘With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key functional molecules,has shown great potential in the field of disease prevention and control[1,2].The multi-continental transcriptomics study of tick-borne poxvirus not only provides a new perspective for understanding the evolution and transmission of vector-mediated viruses,but also reflects the trend of transcriptomics research and highlights its key role in disease prevention and control[3].
文摘This letter evaluates Shahid et al’s study in 2025 on the rising hepatitis A virus(HAV)among adults in Pakistan,highlighting a shift in the virus’s epidemiology.Once primarily a childhood disease in low-income regions,HAV is now increasingly affecting adults,also seen globally due to improved sanitation.The study highlights public health challenges from adult HAV infections,which can lead to complications like coagulopathy and acute liver failure.It also has limitations,including being a single-center study and lacking seroprevalence and socioeconomic data,indicating the need for further research.This letter calls for urgent public health measures to extend adult vaccination programs and improve sanitation to address the increasing HAV infection in adult populations.
基金supported by funding from the National Natural Science Foundation of China(32072191)Special Funds for Guiding Local Scientific and Technological Development by the Central Government(Guike ZY22096025)。
文摘Probiotics show anti-influenza activity,offering a potential variant-resistant alternative for infection prevention and control.In this study,we evaluated whether a specially formulated yogurt enriched with synbiotics(named yogurt 1)with 7 probiotics and 6 prebiotics,has anti-influenza effects and its underlying mechanisms using a mouse model challenged with influenza virus H1N1 PR8 strain.The mice were treated with phosphate-buffered saline(negative control),yogurt matrix,yogurt 1,and oseltamivir(positive control),respectively.Yogurt 1 treatment improved the survival of infected mice(from 0%to 30%),alleviated pathological injuries in the lungs and colon,and reduced the viral load of influenza virus on day 3 and day 7 post-infection.Yogurt 1 also downregulated some inflammation-related signaling pathways and reduced the levels of proinflammatory cytokines or chemokines in the lungs or serum,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α(TNF-α)and keratinocyte chemoattractant(KC).The levels of short-chain fatty acids in the cecal content were increased,the diversity of the intestinal flora was partially restored,and influenza-specific Ig G and interferon-secreting lymphocytes were enhanced following yogurt 1 administration.Thus,yogurt 1,as a commercial and easily accessible dairy product,demonstrated a notable anti-influenza effect in mice by inhibiting viral proliferation,suppressing excessive inflammatory responses,and promoting influenza virus-specific adaptive humoral and cellular immune responses,demonstrating its potential for influenza epidemic prevention and control.
文摘BACKGROUND Colorectal cancer has a high incidence and mortality rate,and the effectiveness of routine colonoscopy largely depends on the endoscopist’s expertise.In recent years,computer-aided detection(CADe)systems have been increasingly integrated into colonoscopy to improve detection accuracy.However,while most studies have focused on adenoma detection rate(ADR)as the primary outcome,the more sensitive adenoma miss rate(AMR)has been less frequently analyzed.AIM To evaluate the effectiveness of CADe in colonoscopy and assess the advantages of AMR over ADR.METHODS A comprehensive literature search was conducted in PubMed,Embase,and the Cochrane Central Register of Controlled Trials using predefined search strategies to identify relevant studies published up to August 2,2024.Statistical analyses were performed to compare outcomes between groups,and potential publication bias was assessed using funnel plots.The quality of the included studies was evaluated using the Cochrane Risk of Bias tool and the Grading of Recommendations,Assessment,Development,and Evaluation approach.RESULTS Five studies comprising 1624 patients met the inclusion criteria.AMR was significantly lower in the CADe-assisted group than in the routine colonoscopy group(147/927,15.9%vs 345/960,35.9%;P<0.01).However,CADe did not provide a significant advantage in detecting advanced adenomas or lesions measuring 6-9 mm or≥10 mm.The polyp miss rate(PMR)was also lower in the CADe-assisted group[odds ratio(OR),0.35;95% confidence interval(CI):0.23-0.52;P<0.01].While the overall ADR did not differ significantly between groups,the ADR during the first-pass examination was higher in the CADe-assisted group(OR,1.37;95%CI:1.10-1.69;P=0.004).The level of evidence for the included randomized controlled trials was graded as moderate.CONCLUSION CADe can significantly reduce AMR and PMR while improving ADR during initial detection,demonstrating its potential to enhance colonoscopy performance.These findings highlight the value of CADe in improving the detection of colorectal neoplasms,particularly small and histologically distinct adenomas.
基金supported by the earmarked fund for National Natural Science Foundation of China(32230105)the China Agriculture Research System(CARS-41)the National Major Agricultural Science and Technology Projects,China(NK2022100103)。
文摘Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV)in poultry.ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K).Among them,ALV-J was first introduced into China in 1999,spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens.ALV-J typically induces myeloid leukosis in infected chickens,but also induces a high proportion of hemangiomas in infected layer chickens,posing a serious threat to poultry breeds in China.As a retrovirus,the genome of ALV-J has undergone significant mutations,which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J.Over the last two decades,the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry.Specialized detection assays have been developed to combat ALV-J infections in China.Additionally,ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections.This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.
文摘With the implementation of significant national strategies and rapid socioeconomic development,many ultra-long deep tunnels are being constructed in the Qinghai–Xizang Plateau region.However,the extreme complexity and variability of the environment in this region pose significant challenges to the safe construction and long-term operation of the planned or under-construction ultra-long deep tunnels.To address these complex technical challenges,this paper provides a detailed analysis of the complex climate and geology features of the Qinghai–Xizang Plateau during tunnel construction.The climate characteristics of the Qinghai–Xizang Plateau include severe coldness,low oxygen,and unpredictable weather changes.The geological characteristics include complex stress distributions caused by the intense internal and external dynamic coupling of tectonic plates,widespread active tectonic structures,frequent high-intensity earthquakes,fractured rock masses,and numerous active fault zones.Based on the analysis,this paper elaborates on potential sources of major disasters resulting from the characteristics of ultra-long deep tunnel projects in the Qinghai–Xizang Plateau region.These potential disaster sources include the crossing of active fault zones,high geostress rockbursts,large deformation disasters,high-pressure water surges,geothermal hazards,inadequate long-distance ventilation and oxygen supply,and multi-hazard couplings.In response to these challenges,this paper systematically summarizes the latest research progress and technological achievements in the domestic and international literature,and proposes innovative ideas and future development prospects for disaster monitoring and early warning,mechanized intelligent construction,long-term safety services,and emergency security and rescue.These innovative measures are intended to address the challenges of tunnel disaster prevention and control in the complex environment of the Qinghai–Xizang Plateau,contributing to the safe construction and long-term operation of ultra-long deep tunnels in this region.
基金financially supported by the National Key Research and Development Program(No.2018YFC1505402)the National Natural Science Foundation of China(No.41871174)+1 种基金the Science and Technology Department of Sichuan Province(No.2020YFSY0013)the Fundamental Research Funds for the Central Universities Project(No.2682019CX19)。
文摘Benefit evaluation of debris flow prevention and control projects was one of the essential contents of debris flow prevention and mitigation work.In order to scientifically and quantitatively evaluate the comprehensive benefit of debris flow prevention and control projects,this study identified nine factors as evaluation indicators from economic,social,and ecological aspects.The projection pursuit(PP) model based on the improved particle swarm optimization(IPSO) algorithm was used to construct a mathematical model to evaluate the benefit of debris flow prevention and control projects.The interpolation method was applied to divide the benefit grades.The debris flow prevention and control projects in Qipan,Taoguan,Chutou,Anjia,and Mozi gullies in Wenchuan County were chosen as typical cases for empirical analysis.The case study revealed that,among the criteria layer indicators,investment per unit of the protected area,investment per unit of the protected population,the amount of water and soil conservation,and reduction rate of accumulation fan had the most significant weights.The social and ecological benefits were found to be the more important in the target layer.The comprehensive benefit of Qipan,Taoguan,Chutou,Anjia,and Mozi gullies was found to be 4.44,4.83,1.95,3,and 2,respectively.The benefit ranking of the five gullies was consistent with their effectiveness in disaster prevention ranking in the flood season of 2019.Therefore,it could prove that the newly-built benefit evaluation model was practical and feasible,and the evaluation results of the sample could be reasonably interpreted,which verified the effectiveness of the methods.
文摘This paper focuses on the key role and practical paths of operating room nurses in infection control,and studies the difficult problems in the prevention and control of surgical site infections.Analyze the infection risk links in the operating room and the core responsibilities of nurses,reveal the multiple role mechanisms of nurses in infection control,design practical strategies from dimensions such as process optimization,skill improvement,and monitoring feedback,and construct an infection control system involving all staff.Research shows that operating room nurses can effectively reduce the risk of infection,improve medical quality,provide core guarantees for patient safety,and promote the transformation of operating room infection control towards refined management through practical actions such as standardized operation execution,real-time risk monitoring,and team collaboration supervision.
基金supported by the Natural Science Foundation of Henan Province(242300421246)the National Natural Science Foundation of China(52004082,U24B2041,52174073,52274079)+2 种基金the Key Research and Development Program of Henan Province(251111320400)the Program for Science&Technology Innovation Talents in Universities of Henan Province(24HASTIT021)the Program for the Scientific and Technological Innovation Team in Universities of Henan Province(23IRTSTHN005).
文摘With the depletion of shallow mineral resources,mining operations are extending to greater depths and larger scales,increasing the risk of water inrush disasters,particularly from confined aquifers intersected by faults.This paper reviews the current state of research on fault-induced water inrushes in mining faces,examining the damage characteristics and permeability of fractured floor rock,the mechanical behavior of faults under mining stress,and the mechanisms driving water inrush.Advances in prevention technologies,risk assessment,and prediction methods are also summarized.Research shows that damage evolution in fractured floor rock,coupled with fluid-solid interactions,provides the primary pathways for water inrush.Stress-seepage coupling in porous media plays a decisive role in determining inrush potential.Mining-induced stress redistribution can activate faults,with parameters such as dip angle and internal friction angle controlling stress evolution and slip.Critical triggers include the hydraulic connectivity among faults,aquifers,and mining-induced fracture networks,followed by hydraulic erosion.A multi-pronged prevention framework has been developed,integrating precise fault detection,targeted grouting for water sealing,drainage to reduce water pressure,optimized waterproof coal pillar design,and dynamic risk assessment and prediction.However,gaps remain in understanding multi-physical field coupling under deep mining conditions,establishing quantitative criteria for fault activation-induced water inrush,and refining control technologies.Future work should focus on multi-scale numerical simulations,advanced active control measures,and intelligent,integrated prevention systems to clarify the mechanisms of fault-induced water inrush and enhance theoretical and technical support for mine safety.
基金Supported by College-level Scientific Research Project of Guizhou Industry Polytechnic College(2023ZK112023ZK10)Scientific and Technological Innovation Team Project of Guizhou Industry Polytechnic College(2023CXTD03).
文摘To further enhance the yield and quality of kiwifruit and promote the sustainable development of the kiwifruit industry,this paper summarized the characteristics,damage sites,and control methods of major kiwifruit diseases and pests.It pointed out the main issues in current kiwifruit pest and disease management and proposed corresponding solutions.The prevention and control of kiwifruit pests should adhere to the principle of"prevention first,integrated management",and standardized planting modes should be implemented.In this process,priority should be given to agricultural,physical,and biological control methods to effectively reduce the use of chemical pesticides.
基金supported by the Science and Technology Planning Project of Guangdong Province(2023A1111120011)the Natural Science Foundation of Guangdong Province(2024A1515010801).
文摘Objective:To investigate the lifestyle and myopia among primary school students in urban areas of Fujian with the context of myopia prevention and control measures,aiming to provide scientific evidence for identifying high-risk myopia population and formulating effective intervention strategies.Methods:A cross-sectional study was conducted from October to November 2023,enrolling 811 fourth-grade students from three primary schools in three cities across Fujian.Personal information and lifestyle-related pattern were collected using customized questionnaire.Participants underwent comprehensive ophthalmic assessments including distance visual acuity tests and refractive examinations.Logistic regression analysis was used to assess the impact of lifestyle on the onset of myopia.Results:The prevalence of myopia among fourth-grade students in urban primary schools in Fujian was 46.4%.Only 25.8%students engaged in outdoor activities for more than 2 hours daily,while63.3%participated in outdoor activities during class breaks.Multivariate Logistic regression analysis revealed that outdoor activities during class breaks(OR=0.646(95%confidence interval(CI):0.473-0.881),P=0.006)and daily time spent outdoors(2-3 hours,OR=0.682(95%CI:0.466-0.993),P=0.047;more than 3 hours,OR=0.403(95%CI:0.192-0.796),P=0.01)were independent protective factors against myopia.Lifestyle significantly enhanced the predictive performance for myopia(P=0.01).Additionally,parental myopia(one parent with myopia,OR=2.247(95%CI:1.612-3.145),P<0.001;both parents with myopia,OR=4.824(95%CI:3.262-7.204),P<0.001)emerged as a key risk factor for myopia.Conclusions:There is considerable scope for improving the lifestyle of primary school students in urban areas of Fujian.Lifestyle is strongly associated with myopia onset,highlighting the need for schools and families to actively encourage students to engage in more outdoor activities and take breaks outdoors to prevent and control myopia.Students with parents,especially both parents,having myopia should be considered as a key target group for myopia prevention efforts.
基金supported by the National Natural Science Foundation of China(No.U23A2045)the China Three Gorges Corporation(YM(BHT)/(22)022).
文摘Economically and effectively managing the risk of landslide-generated impulse waves(LGIWs)presents a significant challenge following the impoundment of newly constructed reservoirs in western China.To address this issue,we selected the Wangjiashan(WJS)landslide in the Baihetan Reservoir area as a case study to evaluate LGIW hazards and develop corresponding mitigation strategies.Using 2D physical model tests and 3D numerical simulations,we established a 3D hazard assessment method for LGIWs based on 2D experimental results.This method confirmed the effectiveness of slope-cutting engineering in mitigating LGIW hazards.Based on this assessment framework,we proposed a novel approach for LGIW risk reduction.The results showed that the maximum wave amplitude reached 19.64 m in the Jinsha River channel,and the maximum run-up was 11.5 m in the XiangBiLing(XBL)community,indicating a substantial LGIW threat to the area.By reducing the rear edge of the sliding mass to 920 m above sea level(asl),the LGIW risk to the XBL community could be lowered to a tolerable level.Compared with traditional landslide prevention and control measures,the proposed mitigation scheme can reduce excavation costs by approximately 37 million CNY,making it a more scientifically sound and economically feasible solution.We explored the concept and the implementation of LGIW risk mitigation in depth,offering new insights for global LGIW risk management.This case study enhances our understanding of LGIW hazard prevention and provides valuable guidance for policymaking and engineering practices in similar geological settings worldwide.
文摘As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.
文摘In this study, RT-PCR was performed on lung tissue samples from sick pigs in a suspected outbreak of porcine reproductive and respiratory syndrome (PRRS) at a pig farm in Mianyang City, Sichuan Province, China. Positive samples were inoculated into Marc-145 cells to observe lesions. The Marc-145 cells with cytopathic lesions were identified by indirect immunofluorescence. The whole genome sequences of the isolated and purified strains were amplified by RT-PCR and analyzed for homology and genetic evolution. A strain of porcine reproductive and respiratory syndrome virus (PRRSV), named SCMY2023 (GenBank No. PQ179742), was successfully isolated. SCMY2023 has a genome length of 15,321 base pairs (without a poly A tail). Nucleotide and amino acid homology analyses suggest that this strain belongs to Lineage 8, a variant of the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) prevalent in China. Recombination and genetic evolution analyses indicate that this isolate is a PRRSV variant that recombined with HuN-ZZ (Lineage 8, 98.79% homology) on the backbone of the SCSN2020 strain (Lineage 8, 99.35% homology) in the recombination region from 4407 to 13,107 nucleotides (ORF1a to ORF3). In-depth study of the genetic recombination of this isolate can provide a reference for the prevention and control of PRRS.
文摘Acquired Immunodeficiency Syndrome(AIDS)caused by Human Immunodeficiency Virus(HIV)infection poses a serious threat to global public health.This article comprehensively reviews the epidemiological characteristics of HIV infection,including the global and domestic epidemic situation,transmission routes,and characteristics of high-risk groups.It also introduces comprehensive prevention and control strategies in detail.Through analysis,it aims to provide a reference for further optimizing HIV prevention and control work.
基金The work was carried out in the framework of earmarked funding“Assessment of seismic hazard of territories of Kazakhstan on modern scientific and methodological basis”,programme code number F.0980.Source of funding-Ministry of Science and Higher Education of the Republic of Kazakhstan.
文摘This article aims to enhance seismic hazard assessment methods for Kazakhstan’s seismotectonic conditions.It combines probabilistic seismic hazard analysis(PSHA),ground motion simulation,sitespecific geological and geotechnical data analysis,and seismic scenario analysis to develop Probabilistic General Seismic Zoning(GSZ)maps for Kazakhstan and Probabilistic Seismic Microzoning maps for Almaty.These maps align with Eurocode 8 principles,incorporating seismic intensity and engineering parameters like peak ground acceleration(PGA).The new procedure,applied in national projects,has resulted in GSZ maps for the country,seismic microzoning maps for Almaty,and detailed seismic zoning maps for East Kazakhstan.These maps,part of a regulatory document,guide earthquake-resistant design and construction.They offer a comprehensive assessment of seismic hazards,integrating traditional Medvedev-Sponheuer-Karnik(MSK-64)intensity scale points with quantitative parameters like peak ground acceleration.This innovative approach promises to advance methods for quantifying seismic hazards in specific regions.
文摘High-end club decoration projects require the integration of multifunctional spaces,high-precision craftsmanship,and eco-friendly material applications.Their complexity necessitates the construction of a closed-loop management system across the entire process,utilizing BIM technology for design optimization,blockchain for material traceability,and Monte Carlo simulations for risk quantification.AI visual inspection and dynamic risk assessment models enable precise identification of process defects and safety hazards,while standardized craftsmanship,intelligent monitoring,and optimized emergency plans ensure engineering quality and safety.The integration of low-carbon material innovation and intelligent technologies drives the industry toward efficient,green,and sustainable development,offering systematic solutions for high-end decoration projects.
文摘This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analysis revealed ten significant issues related to HIV risk behaviors among university students, leading to suggested intervention strategies to address these behaviors.
