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PRETTA:A COMPUTER PROGRAM FOR PWR PRESSURIZER’S TRANSIENT THERMODYNAMICS 被引量:2
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作者 ARSHAD MAHMOOD( 《Journal of Shanghai Jiaotong university(Science)》 EI 2001年第2期181-186,共6页
A computer program PRETTA “Pressurizer Transient Thermodynamics Analysis” was developed for the prediction of pressurizer under transient conditions. It is based on the solution of the conservation laws of heat and ... A computer program PRETTA “Pressurizer Transient Thermodynamics Analysis” was developed for the prediction of pressurizer under transient conditions. It is based on the solution of the conservation laws of heat and mass applied to the three separate and non equilibrium thermodynamic regions. In the program all of the important thermal-hydraulics phenomena occurring in the pressurizer: stratification of the hot water and incoming cold water, bulk flashing and condensation, wall condensation, and interfacial heat and mass transfer have been considered. The bubble rising and rain-out models are developed to describe bulk flashing and condensation, respectively. To obtain the wall condensation rate, a one-dimensional heat conduction equation is solved by the pivoting method. The presented computer program will predict the pressure-time behavior of a PWR pressurizer during a variety of transients. The results obtained from the proposed mathematical model are in good agreement with available data on the CHASHMA nuclear power plant's pressurizer performance. 展开更多
关键词 computer program pressurizer pressure transient prediction
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Research on the steam–gas pressurizer model with Relap5 code 被引量:1
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作者 Xi-Zhen Ma Hai-Jun Jia Yang Liu 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第5期1-8,共8页
Steam–gas pressurizers are self-pressurizing, and since steam and noncondensable gas are used to sustain their pressure, they experience very complicated thermal–hydraulic phenomena owing to the presence of the latt... Steam–gas pressurizers are self-pressurizing, and since steam and noncondensable gas are used to sustain their pressure, they experience very complicated thermal–hydraulic phenomena owing to the presence of the latter. A steam–gas pressurizer model was developed using Relap5 code to investigate such a pressurizer's thermal–hydraulic characteristics.The important thermal–hydraulic processes occurring in the pressurizer model include bulk flashing, rainout, wall condensation with noncondensable gas, and interfacial heat and mass transfer. The pressurizer model was verified using results from insurge experiments performed at the Massachusetts Institute of Technology. It was found that noncondensable gas was one of the important factors governing the pressure response, and the accuracy of the developed model would change with different mass fractions and types of noncondensable gas. 展开更多
关键词 RELAP5 code Noncondensable GAS Heat and mass TRANSFER Steam–gas pressurizer CONDENSATION
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Application of adaptive fuzzy control technology to pressure control of a pressurizer 被引量:1
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作者 YANGBen-kun BIANXin-qian GUOWei-lai 《Journal of Marine Science and Application》 2005年第1期39-43,共5页
A pressurizer is one of important equipment in a pressurized water reactor plant. It is used to maintain the pressure of primary coolant within allowed range because the sharp change of coolant pressure affects the se... A pressurizer is one of important equipment in a pressurized water reactor plant. It is used to maintain the pressure of primary coolant within allowed range because the sharp change of coolant pressure affects the security of reactor, therefor, the study of pressurizer’s pressure control methods is very important. In this paper, an adaptive fuzzy controller is presented for pressure control of a presurizer in a nuclear power plant. The controller can on-line tune fuzzy control rules and parameters by self-learning in the actual control process, which possesses the way of thinking like human to make a decision. The simulation results for a pressurized water reactor plant show that the adaptive fuzzy controller has optimum and intelligent characteristics, which prove the controller is effective. 展开更多
关键词 fuzzy control pressurizer pressure control SIMULATION
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High Temperature Resistant Calcium-doped Silica Aerogels with Enhanced Thermal Insulation via Sol-Gel Hydrothermal Route
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作者 LI Hao QI Yuan +2 位作者 GAO Xiangdong ZHANG Xingxing WANG Jinmin 《无机材料学报》 北大核心 2026年第2期262-272,I0011,共12页
Silica aerogel has broad applications in the field of high-temperature thermal insulation due to its low density,low thermal conductivity and high stability.However,its thermal insulation performance deteriorates sign... Silica aerogel has broad applications in the field of high-temperature thermal insulation due to its low density,low thermal conductivity and high stability.However,its thermal insulation performance deteriorates significantly at elevated temperatures exceeding 600℃,primarily due to the collapse of pore structure.Meanwhile,the shielding capacity of SiO_(2) aerogel to the infrared radiation at high temperature is rather low due to the intrinsic properties of SiO_(2).Herein,a strategy for improving the high-temperature stability and infrared shielding properties of SiO_(2) aerogel via Ca doping was explored.Calcium-doped silica aerogel(CSA)powders were prepared by Sol-Gel,hydrothermal,and ambient pressure drying(APD)techniques using water glass and anhydrous calcium chloride as precursors and trimethylchlorosilane as a hydrophobic modifier.The effects of Ca/Si molar ratio in the precursor and hydrothermal conditions(temperature and pH)on the crystalline properties,microscopic morphology and pore structure of CSAs were investigated.The results show that the Ca/Si molar ratio and hydrothermal treatment have significant effects on the microstructure and heat resistance of CSAs in the temperature range of 400-1000℃.The samples sintered at 1000℃have a high specific surface area of 100.1 m^(2)/g and a pore volume of 0.8705 cm^(3)/g,indicating that the CSA has good heat resistance.One-side insulation tests at temperatures up to 600℃show that the sample with a Ca/Si molar ratio of 1.0 has the best insulation performance,with a cold surface temperature of 450℃,which is 27℃lower than that of the pure silica aerogel. 展开更多
关键词 silica aerogel calcium doping high-temperature resistance HYDROTHERMAL ambient pressure drying
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按平均动脉压和脉压分层分析急性缺血性脑卒中患者立即降压治疗的疗效:中国急性缺血性脑卒中降压试验二次分析
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作者 袁源(译) 《中华高血压杂志(中英文)》 北大核心 2026年第1期86-86,共1页
平均动脉压(mean arterial pressure,MAP)和脉压是反映脑灌注的两项指标,其在急性缺血性脑卒中后能否指导降压治疗策略的选择尚不明确。本研究基于中国急性缺血性脑卒中降压试验(the China antihypertensive trial in acute ischemic st... 平均动脉压(mean arterial pressure,MAP)和脉压是反映脑灌注的两项指标,其在急性缺血性脑卒中后能否指导降压治疗策略的选择尚不明确。本研究基于中国急性缺血性脑卒中降压试验(the China antihypertensive trial in acute ischemic stroke,CATIS),根据MAP和脉压水平进行分层,探讨早期降压干预对缺血性脑卒中后不良临床结局的影响。方法:该试验将4 071例收缩压升高的急性缺血性脑卒中患者随机分配至降压治疗组(目标是在随机化后24h内收缩压降低10%~25%,7 d内血压将至<140/90 mm Hg,并在住院期间维持该水平,1 mm Hg=0.133 k Pa)或住院期间停止降压治疗的对照组。 展开更多
关键词 降压治疗 mean arterial pressure 急性缺血性脑卒中
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Pressure calibrations of high-pressure large-volume presses at HPSTAR
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作者 Yongjiang Xu Peiyan Wu +17 位作者 Sheng Shang Xue Wang Taihang Li Shuchang Gao Shijie Lv Hang Cheng Qianzhi Xu Shang Lei Jiajia Feng Lei Zhao Wim van Westrenen Takayuki Ishii Bin Chen Lei Su Yang Ding Wenge Yang Ho-Kwang Mao Yanhao Lin 《Matter and Radiation at Extremes》 2026年第1期111-130,共20页
Large-volume presses(LVPs)are widely utilized in diverse research fields—including high-pressure physics,chemistry,materials science,and Earth and planetary sciences—to investigate the physical and chemical properti... Large-volume presses(LVPs)are widely utilized in diverse research fields—including high-pressure physics,chemistry,materials science,and Earth and planetary sciences—to investigate the physical and chemical properties of materials under extreme high-pressure and hightemperature conditions.A prerequisite for achieving reproducible property measurements is the determination and control of pressure within experimental setups.However,the lack of precise pressure calibration in LVPs hinders the broader application of such devices in ultrahigh-pressure studies.This study employs a suite of standard phase transition-based pressure markers—comprising metallic conductors,semiconductors,and minerals—through both in situ and ex situ identification approaches,to establish pressure calibration curves ranging from 0.4 to>30 GPa for various types of LVP installed at the Center for High Pressure Science and Technology Advanced Research(HPSTAR),Beijing,including piston–cylinder,cubic,and multi-anvil presses.The results provide a unified and traceable pressure reference for highpressure experiments conducted at HPSTAR,while also offering technical guidance and calibration standards for other researchers utilizing similar LVP systems,thereby enabling more consistent comparison between different laboratories.This work facilitates the advancement of LVP research toward broader applications in higher-pressure regimes. 展开更多
关键词 CHEMISTRY earth planetary sciences pressure calibration high pressure physics materials science investigate physical chemical properties materials determination control pressure
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Analysis relationship between body composition and blood pressure among rural adults
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作者 Yunus Elon Evelin Malinti +1 位作者 Joshua H.L.Tobing Samuel Maju Simanjuntak 《Frontiers of Nursing》 2026年第1期51-60,共10页
Objective:Hypertension is a serious public health concern that is influenced by a variety of body composition parameters.This study examines the associations between body composition metrics and blood pressure(BP)in a... Objective:Hypertension is a serious public health concern that is influenced by a variety of body composition parameters.This study examines the associations between body composition metrics and blood pressure(BP)in a rural population,specifically how variations in body fat distribution and other metrics affect systolic blood pressure(SBP)and diastolic blood pressure(DBP).Methods:A cross-sectional study of 226 participants examined the relationships between body composition metrics—such as total body fat,visceral fat,and body mass index(BMI)—and BP.Correlation and regression analyses were used to assess these relationships.Results:The study found substantial positive correlations between visceral fat and total body fat with both SBP and DBP.Visceral fat was strongly connected with both SBP(r=0.145,P=0.030)and DBP(r=0.331,P<0.01),while total body fat was significantly correlated with DBP(r=0.268,P<0.01)but not SBP.Body composition variables explained 12.8% of the variance in SBP(R^(2)=0.128,P=0.001)and 15.0% in DBP(R^(2)=0.150,P<0.001).Conclusions:The study found substantial connections between body composition,particularly visceral and subcutaneous fat and systolic and DBP.Higher levels of visceral fat were linked to elevate BP.Body composition accounted for a significant amount of BP fluctuation. 展开更多
关键词 blood pressure body composition HYPERTENSION systolic and diastolic blood pressure visceral fat
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Experimental Verification of Intrinsic Pressure Framework in an Activity Landscape
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作者 Zihao Sun Longfei Li +6 位作者 Chuyun Wang Jing Wang Huaicheng Chen Gao Wang Fangfu Ye Liyu Liu Mingcheng Yang 《Chinese Physics Letters》 2026年第1期322-326,共5页
The intrinsic pressure framework,which treats self-propelling force as an external force,provides a convenient and consistent description of mechanical equilibrium in active matter.However,direct experimental evidence... The intrinsic pressure framework,which treats self-propelling force as an external force,provides a convenient and consistent description of mechanical equilibrium in active matter.However,direct experimental evidence is still lacking.To validate this framework,here we employ a programmable robotic platform,where a single light-controlled wheeled robot travels in an activity landscape.Our experiments quantitatively demonstrate that the intrinsic pressure difference across the activity interface is balanced by the emerged polarization force.This result unambiguously confirms the theoretical predictions,thus validating the intrinsic pressure framework and laying the experimental foundation for the intrinsic pressure-based mechanical description of dry active matter. 展开更多
关键词 intrinsic pressure framework activity landscape intrinsic pressure difference robotic platform programmable robotic platformwhere self propelling force polarization force mechanical equilibrium
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Application of electrical impedance tomographyguided PEEP titration in acute respiratory distress syndrome patients with intra-abdominal hypertension
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作者 Hui Wen Maiying Fan +5 位作者 Junliang Xiao Zhiqun Liu Xiaohua Liu Shuzhen Mao Xiaotong Han Fengling Ning 《World Journal of Emergency Medicine》 2026年第1期70-75,共6页
BACKGROUND:Individualized positive end-expiratory pressure(PEEP)titration is a crucial technique in mechanical ventilation therapy for acute respiratory distress syndrome(ARDS)patients with intra-abdominal hypertensio... BACKGROUND:Individualized positive end-expiratory pressure(PEEP)titration is a crucial technique in mechanical ventilation therapy for acute respiratory distress syndrome(ARDS)patients with intra-abdominal hypertension(IAH).This study aimed to evaluate the eff ectiveness of electrical impedance tomography(EIT)-guided PEEP titration in this population.METHODS:This prospective study enrolled 36 ARDS patients,including 22 patients with IAH and 14 without IAH.All the patients underwent EIT-guided PEEP titration at the intersection point between alveolar overdistension and collapse during a decremental PEEP trial.The changes in pulmonary ventilation distribution,respiratory mechanics and hemodynamics during the titration process were observed.RESULTS:After EIT-guided PEEP titration was performed,the PEEP,peak inspiratory pressure and plateau pressure increased significantly(P<0.05).Furthermore,no significant differences were observed in respiratory system compliance,tidal volume,driving pressure,or the 4*DP+RR index between the two groups(P>0.05).The mechanical power increased in the non-IAH(NIAH)group after PEEP titration(P<0.05).Ventilation in gravity-dependent lung regions significantly increased(P<0.05),and the oxygenation index(PaO2/FiO2)improved signifi cantly(P<0.05)in both groups.However,blood pressure,heart rate,respiratory rate,central venous pressure,and lactate levels did not signifi cantly change.In the IAH group,the PaO2/FiO2 ratio improved less than that in the NIAH group did(P<0.05).CONCLUSION:In our study,individualized PEEP titration guided by EIT improved oxygenation in ARDS patients with concomitant IAH without signifi cantly aff ecting hemodynamics.The presence of IAH may limit the improvement of oxygenation during EIT-guided PEEP titration. 展开更多
关键词 Acute respiratory distress syndrome Positive end-expiratory pressure Electrical impedance tomography Intra-abdominal pressure
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Deep Learning-Assisted Organogel Pressure Sensor for Alphabet Recognition and Bio-Mechanical Motion Monitoring
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作者 Kusum Sharma Kousik Bhunia +5 位作者 Subhajit Chatterjee Muthukumar Perumalsamy Anandhan Ayyappan Saj Theophilus Bhatti Yung‑Cheol Byun Sang-Jae Kim 《Nano-Micro Letters》 2026年第2期644-663,共20页
Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring,clinical diagnosis,and robotic applications.Nevertheless,... Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human-machine interfaces for real-time health monitoring,clinical diagnosis,and robotic applications.Nevertheless,it remains a critical challenge to simultaneously achieve desirable mechanical and electrical performance along with biocompatibility,adhesion,self-healing,and environmental robustness with excellent sensing metrics.Herein,we report a multifunctional,anti-freezing,selfadhesive,and self-healable organogel pressure sensor composed of cobalt nanoparticle encapsulated nitrogen-doped carbon nanotubes(CoN CNT)embedded in a polyvinyl alcohol-gelatin(PVA/GLE)matrix.Fabricated using a binary solvent system of water and ethylene glycol(EG),the CoN CNT/PVA/GLE organogel exhibits excellent flexibility,biocompatibility,and temperature tolerance with remarkable environmental stability.Electrochemical impedance spectroscopy confirms near-stable performance across a broad humidity range(40%-95%RH).Freeze-tolerant conductivity under sub-zero conditions(-20℃)is attributed to the synergistic role of CoN CNT and EG,preserving mobility and network integrity.The Co N CNT/PVA/GLE organogel sensor exhibits high sensitivity of 5.75 k Pa^(-1)in the detection range from 0 to 20 k Pa,ideal for subtle biomechanical motion detection.A smart human-machine interface for English letter recognition using deep learning achieved 98%accuracy.The organogel sensor utility was extended to detect human gestures like finger bending,wrist motion,and throat vibration during speech. 展开更多
关键词 Wearable ORGANOGEL Deep learning Pressure sensor Bio-mechanical motion
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The mediating effect of blood pressure between healthy lifestyles and stroke:Results from the China Kadoorie Biobank study
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作者 Zidong Wang Jiaxi Zhou +12 位作者 Xikang Fan Jian Su Houyue Geng Xun Wu Yujie Hua Hongfu Ren Jun Lyu Pei Pei Canqing Yu Dianjianyi Sun Yan Lu Jinyi Zhou Ran Tao 《Journal of Biomedical Research》 2026年第1期23-31,共9页
While a healthy lifestyle is known to reduce the risk of stroke,the extent to which blood pressure(BP)mediates this association remains unclear.The present study aimed to quantify the mediating role of BP in the assoc... While a healthy lifestyle is known to reduce the risk of stroke,the extent to which blood pressure(BP)mediates this association remains unclear.The present study aimed to quantify the mediating role of BP in the association between combined lifestyle factors and stroke incidence.Using data from 51929 participants free of major cardiovascular diseases or cancer at baseline,we employed structural equation modeling to assess the mediating effects of systolic(SBP)and diastolic(DBP)blood pressure.During the follow-up,2811 incident stroke cases were identified.A healthy lifestyle was significantly associated with a reduced risk of stroke,with SBP mediating 44.70%(β=-0.0014,95%confidence interval[CI]:-0.0016 to-0.0012)and DBP mediating 37.81%(β=-0.0012,95%CI:-0.0015 to-0.0009)of this association.The mediating effects were attenuated but remained significant for ischemic stroke(SBP:33.21%;DBP:27.24%).In conclusion,approximately two-fifths of the protective association between a healthy lifestyle and stroke may be mediated by BP.These findings suggest that BP control may serve as an important early indicator for evaluating the effectiveness of lifestyle interventions in reducing stroke risk. 展开更多
关键词 STROKE blood pressure LIFESTYLE mediation analysis
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Phase geometric propagation model of spherical projectile impacting thin plate based on shock wave propagation
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作者 Lvtan Chen Qiguang He +3 位作者 Chenyang Wu Ying Chen Qunyi Tang Xiaowei Chen 《Defence Technology(防务技术)》 2026年第2期14-31,共18页
Material phase-transition represents a significant phenomenon and mechanism in the context of hypervelocity protection.This study presents a thorough analysis of the phase-transition phenomena induced by shock pressur... Material phase-transition represents a significant phenomenon and mechanism in the context of hypervelocity protection.This study presents a thorough analysis of the phase-transition phenomena induced by shock pressure as the shock wave propagates initially to the rear of the projectile.The shock wave that induces a phase-transition is commonly referred to as a macroscopic phase-transition wave,whereas the interface that separates the distinct phases is referred to as macroscopic phase-boundary.The contact interface between the spherical projectile and the thin plate,characterized by its curved surface,plays a significant role in the nonlinear propagation and evolution of wave systems.The pressure distribution along the central axis of a spherical projectile is derived in accordance with the linear decay law observed for axial pressure.On this basis,a quadratic function is employed to characterize the trend of changes in wave front pressure,thereby facilitating the establishment of a model for wave front pressure distribution.Using the phase-transition pressure criterion for materials,the wave front phase evolution process is derived,and the macroscopic phase-boundary is determined.Based on the geometric propagation model(GPM)and the pressure distribution of the wave front,a phase geometric propagation model(PGPM)is proposed.The phase distribution of a spherical projectile impacting a thin plate is obtained by theoretical methods.The accuracy of the PGPM is subsequently validated through a comparison of its results with those obtained from numerical simulations. 展开更多
关键词 Hypervelocity impact Debris cloud PHASE-TRANSITION Pressure distribution Phase distribution
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Evaporation of a CO_(2)Droplet in a High Temperature,Supercritical Pressure Environment
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作者 Yendoubouame Lare Koffi Sagna Amah Séna d’Almeida 《Frontiers in Heat and Mass Transfer》 2026年第1期247-265,共19页
This study presents a numerical investigation of the transient relaxation dynamics of a near-critical CO_(2)droplet immersed in a warmer supercritical environment composed of the same fluid.Three thermodynamic regimes... This study presents a numerical investigation of the transient relaxation dynamics of a near-critical CO_(2)droplet immersed in a warmer supercritical environment composed of the same fluid.Three thermodynamic regimes were analysed:quasi-critical(T_(r)=1.01,P_(r)=1.01),transitional(T_(r)=2.01,P_(r)=1.01),and deep supercritical(T_(r)=5.01,P_(r)=3.01).Theevolution of density,temperature,and velocity fieldswas examined to characterize the internal structure and stability of the interfacial transition layer.The evolution of density,temperature,and velocity fields highlights the competition between thermal diffusion,compressibility,andmass confinement in shaping the stability of the interfacial transition layer.Near the critical point,strong gradients and flux discontinuities emerge,consistent with known instabilities,whereas higher reduced conditions promote homogenization and stabilized transport.In the deep supercritical regime,smooth and nearly uniform fields indicate robust thermal stability.The model is validated against prior studies on droplet evaporation under supercritical and trans-critical conditions.Beyond theoretical insights,the results underline practical implications for advanced propulsion,heat transfer,and evaporation systems as well as for safe CO_(2)supercritical storage and extraction processes in energy,aerospace,pharmaceutical,and materials industries. 展开更多
关键词 Navier-Stokes equations EVAPORATION supercritical pressure temperature density and velocity
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Improving Efficiency of Light Pressure Electric Generator Using Graphene Oxide Nanospacer Between Ag Nanoparticles
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作者 Ha Young Lee Sung-Hyun Kim +3 位作者 Sun-Lyeong Hwang Hyung Soo Ahn Heedae Kim Sam Nyung Yi 《Carbon Energy》 2026年第1期38-47,共10页
Improving device efficiency is fundamental for advancing energy harvesting technology,particularly in systems designed to convert light energy into electrical output.In our previous studies,we developed a basic struct... Improving device efficiency is fundamental for advancing energy harvesting technology,particularly in systems designed to convert light energy into electrical output.In our previous studies,we developed a basic structure light pressure electric generator(Basic-LPEG),which utilized a layered configuration of Ag/Pb(Zr,Ti)O_(3)(PZT)/Pt/GaAs to generate electricity based on light-induced pressure on the PZT.In this study,we sought to enhance the performance of this Basic-LPEG by introducing Ag nanoparticles/graphene oxide(AgNPs/GO)composite units(NP-LPEG),creating upgraded harvesting device.Specifically,by depositing the AgNPs/GO units twice onto the Basic-LPEG,we observed an increase in output voltage and current from 241 mV and 3.1μA to 310 mV and 9.3μA,respectively,under a solar simulator.The increase in electrical output directly correlated with the intensity of the light pressure impacting the PZT,as well as matched the Raman measurements,finite-difference time-domain simulations,and COMSOL Multiphysics Simulation.Experimental data revealed that the enhancement in electrical output was proportional to the number of hot spots generated between Ag nanoparticles,where the electric field experienced substantial amplification.These results underline the effectiveness of AgNPs/GO units in boosting the light-induced electric generation capacity,thereby providing a promising pathway for high-efficiency energy harvesting devices. 展开更多
关键词 Ag nanoparticles energy harvesting graphene oxide light pressure PIEZOELECTRIC
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Artificial Intelligence-Enhanced Wearable Blood Pressure Monitoring in Resource-Limited Settings:A Co-Design of Sensors,Model,and Deployment
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作者 Yiming Zhang Shirong Qiu +9 位作者 Kai Du Shun Wu Ting Xiang Kenghao Zheng Zijun Liu Hanjie Chen Nan Ji Fa Wang Weijia Wu Yuan-Ting Zhang 《Nano-Micro Letters》 2026年第5期561-589,共29页
Accurate blood pressure(BP)monitoring is essential for preventing and managing cardiovascular disease.Advancements in materials science,medicine,flexible electronic,and artificial intelligence(AI)have enabled cuffless... Accurate blood pressure(BP)monitoring is essential for preventing and managing cardiovascular disease.Advancements in materials science,medicine,flexible electronic,and artificial intelligence(AI)have enabled cuffless,unobtrusive BP monitoring systems,offering an alternative to traditional sphygmomanometers.However,extending these advances to real-world cardiovascular care particularly in resource-limited settings remains challenging due to constraints in computational resources,power efficiency,and deployment scalability.This review presents a comprehensive synthesis of AI-enhanced wearable BP monitoring,emphasizing its potential for personalized,scalable,and accessible healthcare.We systematically analyze the end-to-end system architecture,from mechano-electric sensing principles and AI-based estimation models to edge-aware deployment strategies tailored for low-resource environments.We further discuss clinical validation metrics and implementation barriers and prospective strategies.To bridge lab-to-field translation,we propose an innovative"sensor-model-deployment-assessment"co-design framework.This roadmap highlights how AI-enhanced BP technologies can support proactive hypertension control and promote cardiovascular health equity on a global scale. 展开更多
关键词 Wearable blood pressure RESOURCE-LIMITED EdgeAI Cardiovascular health
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Curcumin attenuates pressure overload-induced cardiac fibrosis in mice via modulating the miR-29b/HDAC4 axis
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作者 Yu Xiang Ying Lv +2 位作者 Xiao-Xiang Liu Bo-Tao Li Jing Liu 《Asian Pacific Journal of Tropical Biomedicine》 2026年第2期59-67,I0001,I0002,共11页
Objective:To investigate the antifibrotic effects of curcumin in a transverse aortic constriction(TAC)mouse model and elucidate its molecular mechanisms.Methods:Male C57BL/6 mice underwent TAC and received vehicle,low... Objective:To investigate the antifibrotic effects of curcumin in a transverse aortic constriction(TAC)mouse model and elucidate its molecular mechanisms.Methods:Male C57BL/6 mice underwent TAC and received vehicle,low-dose curcumin(50 mg/kg),high-dose curcumin(200 mg/kg),high-dose curcumin plus a scrambled control antagomir,or high-dose curcumin plus anti-miR-29b treatments.Cardiac function was assessed by echocardiography.Fibrosis was evaluated by histology,collagen volume fraction,and hydroxyproline content.Expression of miR-29b,HDAC4,and fibrosis-related markers(Col1a1,Col3a1,TGF-β1)was measured by quantitative RT-PCR and Western blotting assays.Myocardial procollagen type I carboxy-terminal propeptide was determined by ELISA,and HDAC4-specific enzymatic activity was assayed using a fluorogenic kit.Results:Curcumin improved cardiac function,reduced fibrosis,restored miR-29b expression,and suppressed HDAC4 expression and activity in a dose-dependent manner.Furthermore,curcumin decreased myocardial procollagen type I carboxy-terminal propeptide levels,confirming reduced collagen synthesis.Anti-miR-29b administration partially abrogated the antifibrotic and cardioprotective effects of curcumin.Conclusions:Curcumin attenuates pressure overload-induced cardiac fibrosis and dysfunction in a TAC mouse model via modulation of the miR-29b/HDAC4 axis and suppression of collagen synthesis. 展开更多
关键词 CURCUMIN Cardiac fibrosis MiR-29b HDAC4 Heart failure Pressure overload
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Curvilinear Supine Position for Pressure Injury Prevention in Pediatric Cardiac Surgery Patients:A Randomized Controlled Trial
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作者 Qianxue Yang Xiuli Xiao +2 位作者 Minzhe Xing Shuo Qin Xian Li 《Journal of Clinical and Nursing Research》 2026年第1期345-353,共9页
Background:Pressure injury(PI)is a prevalent complication in pediatric cardiac surgery,with higher incidence than in general pediatric populations due to children’s thin skin,underdeveloped subcutaneous tissue,and pr... Background:Pressure injury(PI)is a prevalent complication in pediatric cardiac surgery,with higher incidence than in general pediatric populations due to children’s thin skin,underdeveloped subcutaneous tissue,and prolonged intraoperative pressure.Objective:To evaluate the effectiveness of the curvilinear supine position(CSP)in preventing PI among children undergoing congenital heart disease(CHD)surgery.Methods:Between October 2024 and February 2025,a single-center randomized controlled trial was conducted.Of the 80 children initially enrolled for congenital heart disease(CHD)surgery,77(aged 1 month to 14 years)completed the study and were included in the final analysis after 3 were excluded due to protocol violations.Participants were randomly assigned to the CSP group(n=38)or the conventional supine position group(n=39).Results:The incidence of PI was significantly lower in the CSP group(2.6%)compared to the control group(20.5%)(p=0.029).Postoperative LDH levels were also significantly reduced in the CSP group(422.67±86.52 U/L vs.592.92±215.71 U/L;p=0.031),while preoperative LDH and surgical variables(e.g.,cardiopulmonary bypass time)were comparable between groups.Although the CSP group had a shorter hospital stay(17.24 vs.22.51 days),the difference was not statistically significant(p=0.085).Caregiver satisfaction was significantly higher in the CSP group(100.0%vs.84.6%;p=0.025).Conclusion:CSP effectively reduces PI incidence,mitigates tissue injury,and enhances caregiver satisfaction in pediatric cardiac surgery,offering a safe and feasible strategy for perioperative PI prevention. 展开更多
关键词 Curvilinear supine position Pressure injury CHILDREN Perioperative nursing Cardiac surgery
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Plasma Metabolites Mediate the Associations of Gut Microbial Diversity with Ambulatory Blood Pressure and Its Variability
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作者 Zhenghao Tang Zhennan Lin +9 位作者 Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Keyong Huang Hongfan Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu 《Biomedical and Environmental Sciences》 2026年第1期26-35,共10页
Objective Evidence suggests that depleted gut microbialα-diversity is associated with hypertension;however,whether metabolic markers affect this relationship remains unknown.We aimed to determine the potential metabo... Objective Evidence suggests that depleted gut microbialα-diversity is associated with hypertension;however,whether metabolic markers affect this relationship remains unknown.We aimed to determine the potential metabolites mediating the associations ofα-diversity with blood pressure(BP)and BP variability(BPV).Methods Metagenomics and plasma targeted metabolomics were conducted on 523 Chinese participants from the MetaSalt study.The 24-hour,daytime,and nighttime BP and BPV were calculated based on ambulatory BP measurements.Linear mixed models were used to characterize the relationships betweenα-diversity(Shannon and Chao1 index)and BP indices.Mediation analyses were performed to assess the contribution of metabolites to the observed associations.The influence of key metabolites on hypertension was further evaluated in a prospective cohort of 2,169 participants.Results Gut microbial richness(Chao1)was negatively associated with 24-hour systolic BP,daytime systolic BP,daytime diastolic BP,24-hour systolic BPV,and nighttime systolic BPV(P<0.05).Moreover,26 metabolites were strongly associated with richness(Bonferroni P<0.05).Among them,four key metabolites(imidazole propionate,2-hydroxy-3-methylbutyric acid,homovanillic acid,and hydrocinnamic acid)mediated the associations between richness and BP indices(proportions of mediating effects:14.1%–67.4%).These key metabolites were also associated with hypertension in the prospective cohort.For example,each 1-standard deviation unit increase in hydrocinnamic acid significantly reduced the risk of prevalent(OR[95%CI]=0.90[0.82,0.99];P=0.03)and incident hypertension(HR[95%CI]=0.83[0.71,0.96];P=0.01).Conclusion Our results suggest that gut microbial richness correlates with lower BP and BPV,and that certain metabolites mediate these associations.These findings provide novel insights into the pathogenesis and prevention of hypertension. 展开更多
关键词 Ambulatory blood pressure monitoring Gut microbial richness Plasma metabolites MEDIATION HYPERTENSION
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Enhancing Heat Exchanger Performance through Passive Techniques:A Comprehensive Review
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作者 Muhammad Waheed Azam Uzair Sajjad +1 位作者 Faisal Maqbool Giovani Sempirini 《Frontiers in Heat and Mass Transfer》 2026年第1期25-53,共29页
Heat exchangers play a crucial role in thermal energy systems,with their performance directly impacting efficiency,cost,and environmental impact.Apowerful technique for performance improvement can be given by passive ... Heat exchangers play a crucial role in thermal energy systems,with their performance directly impacting efficiency,cost,and environmental impact.Apowerful technique for performance improvement can be given by passive enhancement strategies,which are characterized by their dependability and minimal external power requirements.This comprehensive review critically assesses recent advancements in such passive methods to evaluate their heat transfer mechanisms,performance characteristics,and practical implementation challenges.Our methodology involves a systematic and comprehensive analysis of various heat transfer enhancement techniques,including surface modifications,extended surfaces,swirl flow devices,and tube inserts.This approach synthesizes and integrates findings from a broad spectrum of experimental investigations and numerical simulations to establish a cohesive understanding of their performance characteristics and underlyingmechanisms.Based on the findings,passive heat transfer techniques result in significant improvements in thermal performance;for instance,corrugated and roughened surfaces increase the heat transfer coefficient by 50%–200%,and advanced insert geometries,such as modified twisted tapes,can increase it by more than 300%,typically accompanied by significant pressure-drop penalties.However,an important finding is the general trade-off between enhanced heat transfer and higher frictional loss,which requires optimization depending on the applications.Finally,this review also provides recommendations that will document the gaps of various passive techniques in heat exchangers to future address. 展开更多
关键词 Heat transfer enhancement passive techniques pressure drop heat exchangers
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Experimental investigation on trigger dynamics of molten droplet under external disturbance pressure during fuel-coolant interaction
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作者 He-Lin Chen Cheng Peng +2 位作者 Xian-Pin Meng Jian Deng Jiang Wu 《Nuclear Science and Techniques》 2026年第3期189-207,共19页
Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam expl... Fuel-coolant interaction(FCI)remains one of the most complex challenges in severe accident research,with the triggering process being a key aspect that may govern subsequent fine fragmentation and potential steam explosions.In this study,the evolution characteristics of droplet-water interactions under external disturbance conditions were investigated using a self-designed FCI experimental setup.The experimental observations revealed that cavity formation reduced the drag force on the droplet,thereby increasing its peak velocity.However,the external disturbance pressure can disrupt the cavity,leading to a reduction in the droplet peak velocity.Furthermore,it was found that an increase in external disturbance pressure tended to increase the peak value of the droplet expansion rate,thereby promoting the fine-fragmentation process.This effect holds regardless of the initial droplet temperature,coolant temperature,or even when using droplet materials such as lead,which is generally considered unfavorable for steam explosions.Comparative analyses indicated that a higher external disturbance pressure may shorten the triggering time of the droplet surface and enhance the trigger intensity.These findings provide important phenomenological insights for further investigation of the triggering mechanisms in the initial stage of fuel-coolant interactions. 展开更多
关键词 External disturbance pressure Molten droplet Transit velocity Expansion rate Fuel-coolant interaction
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