In the PSP(Pressure-Sensitive Paint),image deblurring is essential due to factors such as prolonged camera exposure times and highmodel velocities,which can lead to significant image blurring.Conventional deblurring m...In the PSP(Pressure-Sensitive Paint),image deblurring is essential due to factors such as prolonged camera exposure times and highmodel velocities,which can lead to significant image blurring.Conventional deblurring methods applied to PSP images often suffer from limited accuracy and require extensive computational resources.To address these issues,this study proposes a deep learning-based approach tailored for PSP image deblurring.Considering that PSP applications primarily involve the accurate pressure measurements of complex geometries,the images captured under such conditions exhibit distinctive non-uniform motion blur,presenting challenges for standard deep learning models utilizing convolutional or attention-based techniques.In this paper,we introduce a novel deblurring architecture featuring multiple DAAM(Deformable Ack Attention Module).These modules provide enhanced flexibility for end-to-end deblurring,leveraging irregular convolution operations for efficient feature extraction while employing attention mechanisms interpreted as multiple 1×1 convolutions,subsequently reassembled to enhance performance.Furthermore,we incorporate a RSC(Residual Shortcut Convolution)module for initial feature processing,aimed at reducing redundant computations and improving the learning capacity for representative shallow features.To preserve critical spatial information during upsampling and downsampling,we replace conventional convolutions with wt(Haar wavelet downsampling)and dysample(Upsampling by Dynamic Sampling).This modification significantly enhances high-precision image reconstruction.By integrating these advanced modules within an encoder-decoder framework,we present the DFDNet(Deformable Fusion Deblurring Network)for image blur removal,providing robust technical support for subsequent PSP data analysis.Experimental evaluations on the FY dataset demonstrate the superior performance of our model,achieving competitive results on the GOPRO and HIDE datasets.展开更多
Global pressure distribution on the suction surface of a single vane in a transonic cascade wind tunnel is measured with the help of intensity-based pressure-sensitive paint (PSP) technique using a type of temperature...Global pressure distribution on the suction surface of a single vane in a transonic cascade wind tunnel is measured with the help of intensity-based pressure-sensitive paint (PSP) technique using a type of temperature-insensitive fluorescent paint and a self-made measurement system. This measurement is conducted at the outlet of the cascade wind tunnel at the Mach numbers 0.3 and 0.4, attack angle about –20°, ambient pressure 95.4 kPa and temperature 15 °C. The vane under study owns a large camber angle of ...展开更多
A mechanical model of the quasi-static interface of a mode I crack between a rigid and a pressure-sensitive viscoelastic material was established to investigate the mechanical characteristic of ship-building engineeri...A mechanical model of the quasi-static interface of a mode I crack between a rigid and a pressure-sensitive viscoelastic material was established to investigate the mechanical characteristic of ship-building engineering hi-materials. In the stable growth stage, stress and strain have the same singularity, ie （σ, ε） ∝ r^-1/（n-1）. The variable-separable asymptotic solutions of stress and strain at the crack tip were obtained by adopting Airy＇s stress function and the numerical results of stress and strain in the crack-tip field were obtained by the shooting method. The results showed that the near-tip fields are mainly governed by the power-hardening exponent n and the Poisson ratio v of the pressure-sensitive material. The fracture criterion of mode I quasi-static crack growth in pressure-sensitive materials, according to the asymptotic analyses of the crack-tip field, can be viewed from the perspective of strain.展开更多
Pressure-sensitive paint(PSP)is a global pressure measurement technique.Compared with pressure transducers,PSP has significant advantages such as high spatial resolution and a lack of contact when applied to fast-rota...Pressure-sensitive paint(PSP)is a global pressure measurement technique.Compared with pressure transducers,PSP has significant advantages such as high spatial resolution and a lack of contact when applied to fast-rotating blades.However,due to the limitations of other pressure measurement techniques,the validation of PSP measurements on fast-rotating blades is generally difficult.In this work,a comprehensive study including PSP measurement,force balance measurement,and simulation was conducted on a 1 m-diameter propeller at the China Aerodynamic Research and Development Center.First,our computational fluid dynamics(CFD)code was validated by comparing the calculated aerodynamic thrust with the results from force balance measurements.Then,the pressure distributions on the propeller blade obtained by PSP were carefully compared with the CFD results under different working conditions.The results of PSP measurements,force balance measurements,and CFD showed good agreement,and the PSP measurement errors were estimated to be less than 5% of the dynamic pressure at the blade tip.Finally,the variations in pressure distribution under different rotating speeds and free-stream velocities were discussed.展开更多
The thermal stability of sprayable fast-responding Pressure-Sensitive Paint(fast PSP)was investigated to explore the possibility for application in turbomachinery and hypersonic research with temperature above 100℃.T...The thermal stability of sprayable fast-responding Pressure-Sensitive Paint(fast PSP)was investigated to explore the possibility for application in turbomachinery and hypersonic research with temperature above 100℃.The first part of the study focused on a widely-used Polymer Ceramic PSP(PC-PSP).The effects of thermal degradation on its key sensing properties,including luminescent intensity,pressure sensitivity and response time,were examined for a temperature range from 60 to 100℃.Severe degradation in intensity and pressure sensitivity was found as temperature reached 70℃or higher,which would cause failure of PSP application in these conditions.Subsequently,a fast-responding Mesoporous-Particle PSP(MP-PSP)was developed which did not show degradation effects until 140℃.The greatly improved thermal stability of MP-PSP was attributed to:selection of polymer with higher glass transition temperature(polystyrene)to delay the saturation effect of oxygen quenching as temperature increased;porous and hollow structure of particles for luminophore deposition that minimizes polymer–luminophore interaction.This new paint formulation has significantly raised the upper temperature limit of fast PSP and offers more opportunities for applications in harsh environment.展开更多
This study clarifies the seepage characteristics of complex fractured pressure-sensitive reservoirs,and addresses a common technological problem,that is the alteration of the permeability degree of the reservoir bed(k...This study clarifies the seepage characteristics of complex fractured pressure-sensitive reservoirs,and addresses a common technological problem,that is the alteration of the permeability degree of the reservoir bed(known to be responsible for changes in the direction and velocity of fluid flows between wells).On the basis of a new pressuresensitive equation that considers the fracture directional pressure-sensitive effect,an oil-gas-water three-phase seepage mathematical model is introduced,which can be applied to pressure-sensitive,full-tensor permeability,ultralow-permeability reservoirs with fracture-induced anisotropy.Accordingly,numerical simulations are conducted to explore the seepage laws for ultralow-permeability reservoirs.The results show that element patterns have the highest recovery percentage under a fracture angle of 45°.Accounting for the pressure-sensitive effect produces a decrease in the recovery percentage.Several patterns are considered:inverted five-seven-and nine-spot patterns and a cross-row well pattern.Finally,two strategies are introduced to counteract the rotation of the direction of the principal permeability due to the fracture directional pressure-sensitive effect.展开更多
Lithiation-induced plasticity is a key factor that enables Si electrodes to maintain long cycle life in Li-ion batteries. We study the plasticity of various lithiated sili-con phases based on first-principles calculat...Lithiation-induced plasticity is a key factor that enables Si electrodes to maintain long cycle life in Li-ion batteries. We study the plasticity of various lithiated sili-con phases based on first-principles calculations and iden-tify the linear dependence of the equivalent yield stress on the hydrostatic pressure. Such dependence may cause the compression-tension asymmetry in an amorphous Si thin film electrode from a lithiation to delithiation cycle, and leads to subsequent ratcheting of the electrode after cyclic lithiation. We propose a yield criterion of amorphous lithi-ated silicon that includes the effects of the hydrostatic stress and the lithiation reaction. We further examine the micro-scopic mechanism of deformation in lithiated silicon under mechanical load, which is attributed to the flow-defects mediated local bond switching and cavitation. Hydrostatic compression confines the flow defects thus effectively strength-ens the amorphous structure, and vice versa.展开更多
An abnormally high peak friction angle of Ottawa sand was observed in(National Aeronautics and Space Administration) NASA–(Mechanics of Granular Materials) MGM tests in microgravity conditions on the space shuttle. P...An abnormally high peak friction angle of Ottawa sand was observed in(National Aeronautics and Space Administration) NASA–(Mechanics of Granular Materials) MGM tests in microgravity conditions on the space shuttle. Previous investigations have been unsuccessful in providing a constitutive insight into this behavior of granular materials under extremely low effective stress conditions. Here, a recently proposed unified constitutive model for transient rheological behavior of sand and other granular materials is adopted for the analytical assessment of high peak friction angles. For the first time, this long-eluded behavior of sand is attributed to a hidden rheological transition mechanism, that is not only rate-sensitive, but also pressure-sensitive. The NASA–MGM microgravity conditions show that shear-tests of sand can be performed under abnormally low confining stress conditions. The pressure-sensitive behavior of granular shearing that is previously ignored is studied based on the μ(I) rheology and its variations. Comparisons between the model and the NASA microgravity tests demonstrate a high degree of agreement. The research is highly valid for pressure-sensitive and rate-dependent problems that occur during earthquakes, landslides, and space exploration.展开更多
Finite element analysis was carried out to investigate the conical indentation response of elastic-plastic solids within the framework of the hydrostatic pressure dependence and the power law strain hardening. A large...Finite element analysis was carried out to investigate the conical indentation response of elastic-plastic solids within the framework of the hydrostatic pressure dependence and the power law strain hardening. A large number of 40 difierent combinations of elasto-plastic properties with n ranging from 0 to 0.5 and σy/E ranging from 0.0014 to 0.03 were used in the computations. The loading curvature C and the average contact pressure Pave were considered within the concept of representative strains and the dimensional analysis.Dimensionless functions associated with these two parameters were formulated for each studied value of the pressure sensitivity. The results for pressure sensitive materials lie between those for Von Mises materials and the elastic model.展开更多
The intraocular pressure inside the human eye maintains 10–21 mmHg above the atmospheric pressure.Elevation of intraocular pressure is highly correlated with the retinopathy in glaucoma,and changes in the exterior pr...The intraocular pressure inside the human eye maintains 10–21 mmHg above the atmospheric pressure.Elevation of intraocular pressure is highly correlated with the retinopathy in glaucoma,and changes in the exterior pressure during mountain hiking,air traveling,and diving may also induce vision decline and retinopathy.The pathophysiological mechanism of these pressure-induced retinal disorders has not been completely clear.Retinal neurons express pressure-sensitive channels intrinsically sensitive to pressure and membrane stretch,such as the transient receptor potential channel(TRP)family permeable to Ca^2+and Na^+and the two-pore domain K channel family.Recent data have shown that pressure excites the primate retinal bipolar cell by opening TRP vanilloid 4 to mediate transient depolarizing currents,and TRP vanilloid 4 agonists enhance the membrane excitability of primate retinal ganglion cells.The eyeball wall is constructed primarily by the sclera and cornea of low elasticity,and the flow rate of the aqueous humor and intraocular pressure both fluctuate,but the mathematical relationship between the ocular elasticity,aqueous humor volume,and intraocular pressure has not been established.This review will briefly review recent literature on the pressure-related retinal pathophysiology in glaucoma and other pressure-induced retinal disorders,the elasticity of ocular tissues,and pressure-sensitive cation channels in retinal neurons.Emerging data support the global volume and the elasticity and thickness of the sclera and cornea as variables to affect the intraocular pressure level like the volume of the aqueous humor.Recent results also suggest some potential routes for TRPs to mediate retinal ganglion cell dysfunction:TRP opening upon intraocular pressure elevation and membrane stretch,enhancing glutamate release from bipolar cells,increasing intracellular Na^+,Ca^2+concentration in retinal ganglion cells and extracellular glutamate concentration,inactivating voltage-gated Na^+channels,and causing excitotoxicity and dysfunction of retinal ganglion cells.Further studies on these routes likely identify novel targets and therapeutic strategies for the treatment of pressure-induced retinal disorders.展开更多
BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with metastases.The effects of T2DM on postoperative chemoresistance rate(CRR)and lo...BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with metastases.The effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain controversial.AIM To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ CC.METHODS This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to 2021.Based on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic control.DFS,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk factors.RESULTS Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.展开更多
BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis th...BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.展开更多
Two sharp Chernoff type inequalities are derived for star bodies in R2,one is an extension of the dual Chernoff-Ou-Pan inequality,and the other is the reverse Chernoff type inequality.Furthermore,we establish a genera...Two sharp Chernoff type inequalities are derived for star bodies in R2,one is an extension of the dual Chernoff-Ou-Pan inequality,and the other is the reverse Chernoff type inequality.Furthermore,we establish a generalized dual symmetric mixed Chernoff inequality for two planar star bodies.As a direct consequence,a new proof of the dual symmetric mixed isoperimetric inequality is presented.展开更多
Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the J...Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the Journal of Sport and Health Science,Liang et al.1 describe results from the UK Biobank data showing the benefits of moderate-to-vigorous intensity physical activity(MVPA)on reducing the risks for vascular events in 11,474 adults with T2D and prediabetes.展开更多
Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture....Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM)often leads to vascular complications,such as albuminuria.The role of insulin autoantibodies(IAA)and their interaction with D-dimer in this context remains unclear.AIM To inves...BACKGROUND Type 2 diabetes mellitus(T2DM)often leads to vascular complications,such as albuminuria.The role of insulin autoantibodies(IAA)and their interaction with D-dimer in this context remains unclear.AIM To investigate the characteristics of IAA and its effect on albuminuria in T2DM patients.METHODS We retrospectively analyzed clinical data from 115 T2DM patients with positive IAA induced by exogenous insulin,and 115 age-and sex-matched IAA-negative T2DM patients as controls.Propensity scores were calculated using multivariate logistic regression.Key variables were selected using the least absolute shrinkage and selection operator(LASSO)algorithm.We constructed a prediction model and analyzed the association between IAA and albuminuria based on demographic and laboratory parameters.RESULTS The IAA-positive group had significantly higher D-dimer levels[0.30(0.19-0.55)mg/L vs 0.21(0.19-0.33)mg/L,P=0.008]and plasma insulin levels[39.1(12.0-102.7)μU/mL vs 9.8(5.5-17.6)μU/mL,P<0.001]compared to the IAA-negative group.Increases in the insulin dose per weight ratio,diabetes duration,and urinary albumin-to-creatinine ratio(UACR)were observed but did not reach statistical significance.The LASSO model identified plasma insulin and D-dimer as key factors with larger coefficients.D-dimer was significantly associated with UACR in the total and IAA-positive groups but not in the IAA-negative group.The odds ratio for D-dimer elevation(>0.5 g/L)was 2.88(95%confidence interval:1.17-7.07)in the IAA-positive group(P interaction<0.05).CONCLUSION D-dimer elevation is an independent risk factor for abnormal albuminuria and interacts with IAA in the development of abnormal albuminuria in T2DM patients.展开更多
Objective This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction(MI)in patients with both coronary heart disease(CHD)and type 2 diabetes(T2D).Methods W...Objective This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction(MI)in patients with both coronary heart disease(CHD)and type 2 diabetes(T2D).Methods We conducted a retrospective cohort study of 33,238 patients with both CHD and T2D in Shenzhen,China.Patients were categorized into 6 groups based on baseline fasting plasma glucose(FPG)levels and diabetes duration(from the date of diabetes diagnosis to the baseline date)to examine their combined effects on subsequent MI.Cox proportional hazards regression models were used,with further stratification by age,sex,and comorbidities to assess potential interactions.Results Over a median follow-up of 2.4 years,2,110 patients experienced MI.Compared to those with optimal glycemic control(FPG<6.1 mmol/L)and shorter diabetes duration(<10 years),the fullyadjusted hazard ratio(HR)(95%Confidence Interval[95%CI])for those with a diabetes duration of≥10 years and FPG>8.0 mmol/L was 1.93(95%CI:1.59,2.36).The combined effects of FPG and diabetes duration on MI were largely similar across different age,sex,and comorbidity groups,although the excess risk of MI associated with long-term diabetes appeared to be more pronounced among those with atrial fibrillation.Conclusion Our study indicates that glycemic control and diabetes duration significant influence the subsequent occurrence of MI in patients with both CHD and T2D.Tailored management strategies emphasizing strict glycemic control may be particularly beneficial for patients with longer diabetes duration and atrial fibrillation.展开更多
Parkinson's disease(PD),a chronic and com-mon neurodegenerative disease,is characterized by the progressive loss of dopaminergic neurons in the dense part of the substantia nigra and abnormal aggregation of alpha-...Parkinson's disease(PD),a chronic and com-mon neurodegenerative disease,is characterized by the progressive loss of dopaminergic neurons in the dense part of the substantia nigra and abnormal aggregation of alpha-synuclein.Type 2 diabetes mellitus(T2DM)is a metabolic disease characterized by chronic insulin resistance and deficiency in insulin secretion.Extensive evidence has con-firmed shared pathogenic mechanisms underlying PD and T2DM,such as oxidative stress caused by insulin resistance,mitochondrial dysfunction,inflammation,and disorders of energy metabolism.Conventional drugs for treating T2DM,such as metformin and glucagon-like peptide-1 receptor ago-nists,affect nerve repair.Even drugs for treating PD,such as levodopa,can affect insulin secretion.This review sum-marizes the relationship between PD and T2DM and related therapeutic drugs from the perspective of insulin signaling pathways in the brain.展开更多
Type 2 diabetes mellitus(T2DM)significantly elevates the risk of colorectal cancer(CRC)and complicates its treatment by promoting chemoresistance.Poor glycemic control has been linked to exacerbated CRC progression an...Type 2 diabetes mellitus(T2DM)significantly elevates the risk of colorectal cancer(CRC)and complicates its treatment by promoting chemoresistance.Poor glycemic control has been linked to exacerbated CRC progression and diminished chemotherapy efficacy,impacting patient outcomes through various mechanisms such as oxidative stress,activation of metabolic pathways,and altered protein modifications that hinder apoptosis and enhance tumor survival.Clinical evidence shows that T2DM patients experience higher rates of chemoresistance and reduced disease-free survival and overall survival compared to non-diabetic patients.Specifically,those with poor glycemic control exhibit increased chemo-resistance and poorer survival metrics.Antidiabetic treatments,including metformin,acarbose,and gliclazide,show promise in improving chemotherapy response and glycemic management,potentially enhancing patient outcomes.Addressing this challenge requires a comprehensive,multidisciplinary approach involving oncologists,endocrino-logists,and surgeons to optimize patient care.Integrated strategies that prioritize glycemic control are essential for reducing chemoresistance and improving survival in CRC patients with T2DM.展开更多
Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method...Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method.GDM diagnosis was based on a 75-g,2-h oral glucose tolerance test(OGTT)according to the criteria of the International Association of Diabetes and Pregnancy Study Groups.Logistic regression was applied to calculate the odds ratios(ORs)and 95%confidence intervals(CIs)between ABO blood types and GDM risk.Results A total of 30,740 pregnant women with a mean age of 31.81 years were enrolled in this study.The ABO blood types distribution was:type O(30.99%),type A(26.58%),type B(32.20%),and type AB(10.23%).GDM was identified in 14.44%of participants.Using blood type O as a reference,GDM risk was not significantly higher for types A(OR=1.05)or B(OR=1.04).However,women with type AB had a 19%increased risk of GDM(OR=1.19,95%CI=1.05–1.34;P<0.05),even after adjusting for various factors.This increased risk for type AB was consistent across subgroup and sensitivity analyses.Conclusion The ABO blood types may influence GDM risk,with type AB associated with a higher risk.Incorporating it—either as a single risk factor or in combination with other known factors—could help identify individuals at risk for GDM before or during early pregnancy.展开更多
基金supported by the National Natural Science Foundation of China(No.12202476).
文摘In the PSP(Pressure-Sensitive Paint),image deblurring is essential due to factors such as prolonged camera exposure times and highmodel velocities,which can lead to significant image blurring.Conventional deblurring methods applied to PSP images often suffer from limited accuracy and require extensive computational resources.To address these issues,this study proposes a deep learning-based approach tailored for PSP image deblurring.Considering that PSP applications primarily involve the accurate pressure measurements of complex geometries,the images captured under such conditions exhibit distinctive non-uniform motion blur,presenting challenges for standard deep learning models utilizing convolutional or attention-based techniques.In this paper,we introduce a novel deblurring architecture featuring multiple DAAM(Deformable Ack Attention Module).These modules provide enhanced flexibility for end-to-end deblurring,leveraging irregular convolution operations for efficient feature extraction while employing attention mechanisms interpreted as multiple 1×1 convolutions,subsequently reassembled to enhance performance.Furthermore,we incorporate a RSC(Residual Shortcut Convolution)module for initial feature processing,aimed at reducing redundant computations and improving the learning capacity for representative shallow features.To preserve critical spatial information during upsampling and downsampling,we replace conventional convolutions with wt(Haar wavelet downsampling)and dysample(Upsampling by Dynamic Sampling).This modification significantly enhances high-precision image reconstruction.By integrating these advanced modules within an encoder-decoder framework,we present the DFDNet(Deformable Fusion Deblurring Network)for image blur removal,providing robust technical support for subsequent PSP data analysis.Experimental evaluations on the FY dataset demonstrate the superior performance of our model,achieving competitive results on the GOPRO and HIDE datasets.
基金National Natural Science Foundation of China (50476071, 10577020)
文摘Global pressure distribution on the suction surface of a single vane in a transonic cascade wind tunnel is measured with the help of intensity-based pressure-sensitive paint (PSP) technique using a type of temperature-insensitive fluorescent paint and a self-made measurement system. This measurement is conducted at the outlet of the cascade wind tunnel at the Mach numbers 0.3 and 0.4, attack angle about –20°, ambient pressure 95.4 kPa and temperature 15 °C. The vane under study owns a large camber angle of ...
基金Supported by Heilongjiang Province Foundation under Grant No.LC08C02
文摘A mechanical model of the quasi-static interface of a mode I crack between a rigid and a pressure-sensitive viscoelastic material was established to investigate the mechanical characteristic of ship-building engineering hi-materials. In the stable growth stage, stress and strain have the same singularity, ie （σ, ε） ∝ r^-1/（n-1）. The variable-separable asymptotic solutions of stress and strain at the crack tip were obtained by adopting Airy＇s stress function and the numerical results of stress and strain in the crack-tip field were obtained by the shooting method. The results showed that the near-tip fields are mainly governed by the power-hardening exponent n and the Poisson ratio v of the pressure-sensitive material. The fracture criterion of mode I quasi-static crack growth in pressure-sensitive materials, according to the asymptotic analyses of the crack-tip field, can be viewed from the perspective of strain.
基金supported by the Foundation of the State Key Laboratory of Aerodynamics(Grant No.SKLA2019040302)the National Natural Science Foundation of China(Grant No.11872038).
文摘Pressure-sensitive paint(PSP)is a global pressure measurement technique.Compared with pressure transducers,PSP has significant advantages such as high spatial resolution and a lack of contact when applied to fast-rotating blades.However,due to the limitations of other pressure measurement techniques,the validation of PSP measurements on fast-rotating blades is generally difficult.In this work,a comprehensive study including PSP measurement,force balance measurement,and simulation was conducted on a 1 m-diameter propeller at the China Aerodynamic Research and Development Center.First,our computational fluid dynamics(CFD)code was validated by comparing the calculated aerodynamic thrust with the results from force balance measurements.Then,the pressure distributions on the propeller blade obtained by PSP were carefully compared with the CFD results under different working conditions.The results of PSP measurements,force balance measurements,and CFD showed good agreement,and the PSP measurement errors were estimated to be less than 5% of the dynamic pressure at the blade tip.Finally,the variations in pressure distribution under different rotating speeds and free-stream velocities were discussed.
基金supported by the National Natural Science Foundation of China(Nos.:11872038 and 11725209)funding from Gas Turbine Research Institute of Shanghai Jiao Tong University。
文摘The thermal stability of sprayable fast-responding Pressure-Sensitive Paint(fast PSP)was investigated to explore the possibility for application in turbomachinery and hypersonic research with temperature above 100℃.The first part of the study focused on a widely-used Polymer Ceramic PSP(PC-PSP).The effects of thermal degradation on its key sensing properties,including luminescent intensity,pressure sensitivity and response time,were examined for a temperature range from 60 to 100℃.Severe degradation in intensity and pressure sensitivity was found as temperature reached 70℃or higher,which would cause failure of PSP application in these conditions.Subsequently,a fast-responding Mesoporous-Particle PSP(MP-PSP)was developed which did not show degradation effects until 140℃.The greatly improved thermal stability of MP-PSP was attributed to:selection of polymer with higher glass transition temperature(polystyrene)to delay the saturation effect of oxygen quenching as temperature increased;porous and hollow structure of particles for luminophore deposition that minimizes polymer–luminophore interaction.This new paint formulation has significantly raised the upper temperature limit of fast PSP and offers more opportunities for applications in harsh environment.
基金This work is financially supported by the National Natural Science Foundation Project(No.51374222)National Major Project(No.2017ZX05032004-002)+2 种基金the National Key Basic Research&Development Program(No.2015CB250905)CNPC’s Major Scientific and Technological Project(No.2017E-0405)SINOPEC Major Scientific Research Project(No.P18049-1).
文摘This study clarifies the seepage characteristics of complex fractured pressure-sensitive reservoirs,and addresses a common technological problem,that is the alteration of the permeability degree of the reservoir bed(known to be responsible for changes in the direction and velocity of fluid flows between wells).On the basis of a new pressuresensitive equation that considers the fracture directional pressure-sensitive effect,an oil-gas-water three-phase seepage mathematical model is introduced,which can be applied to pressure-sensitive,full-tensor permeability,ultralow-permeability reservoirs with fracture-induced anisotropy.Accordingly,numerical simulations are conducted to explore the seepage laws for ultralow-permeability reservoirs.The results show that element patterns have the highest recovery percentage under a fracture angle of 45°.Accounting for the pressure-sensitive effect produces a decrease in the recovery percentage.Several patterns are considered:inverted five-seven-and nine-spot patterns and a cross-row well pattern.Finally,two strategies are introduced to counteract the rotation of the direction of the principal permeability due to the fracture directional pressure-sensitive effect.
基金supported by the National Natural Science Foundation of China (11005124 and 11275229)the Natural Science Foundation of Anhui Province (1208085QA05)+1 种基金the National Fund for Scientific Research (FNRS) of Belgium, support by the SEAS Academic Computing teamthe Extreme Science and Engineering Discovery Environment (XSEDE),supported by NSF of US (TG-DMR130025 andTG-DMR130038)
文摘Lithiation-induced plasticity is a key factor that enables Si electrodes to maintain long cycle life in Li-ion batteries. We study the plasticity of various lithiated sili-con phases based on first-principles calculations and iden-tify the linear dependence of the equivalent yield stress on the hydrostatic pressure. Such dependence may cause the compression-tension asymmetry in an amorphous Si thin film electrode from a lithiation to delithiation cycle, and leads to subsequent ratcheting of the electrode after cyclic lithiation. We propose a yield criterion of amorphous lithi-ated silicon that includes the effects of the hydrostatic stress and the lithiation reaction. We further examine the micro-scopic mechanism of deformation in lithiated silicon under mechanical load, which is attributed to the flow-defects mediated local bond switching and cavitation. Hydrostatic compression confines the flow defects thus effectively strength-ens the amorphous structure, and vice versa.
基金Project supported by the ESA-CMSA/CSU Space Science and Utilization Collaboration Program。
文摘An abnormally high peak friction angle of Ottawa sand was observed in(National Aeronautics and Space Administration) NASA–(Mechanics of Granular Materials) MGM tests in microgravity conditions on the space shuttle. Previous investigations have been unsuccessful in providing a constitutive insight into this behavior of granular materials under extremely low effective stress conditions. Here, a recently proposed unified constitutive model for transient rheological behavior of sand and other granular materials is adopted for the analytical assessment of high peak friction angles. For the first time, this long-eluded behavior of sand is attributed to a hidden rheological transition mechanism, that is not only rate-sensitive, but also pressure-sensitive. The NASA–MGM microgravity conditions show that shear-tests of sand can be performed under abnormally low confining stress conditions. The pressure-sensitive behavior of granular shearing that is previously ignored is studied based on the μ(I) rheology and its variations. Comparisons between the model and the NASA microgravity tests demonstrate a high degree of agreement. The research is highly valid for pressure-sensitive and rate-dependent problems that occur during earthquakes, landslides, and space exploration.
文摘Finite element analysis was carried out to investigate the conical indentation response of elastic-plastic solids within the framework of the hydrostatic pressure dependence and the power law strain hardening. A large number of 40 difierent combinations of elasto-plastic properties with n ranging from 0 to 0.5 and σy/E ranging from 0.0014 to 0.03 were used in the computations. The loading curvature C and the average contact pressure Pave were considered within the concept of representative strains and the dimensional analysis.Dimensionless functions associated with these two parameters were formulated for each studied value of the pressure sensitivity. The results for pressure sensitive materials lie between those for Von Mises materials and the elastic model.
文摘The intraocular pressure inside the human eye maintains 10–21 mmHg above the atmospheric pressure.Elevation of intraocular pressure is highly correlated with the retinopathy in glaucoma,and changes in the exterior pressure during mountain hiking,air traveling,and diving may also induce vision decline and retinopathy.The pathophysiological mechanism of these pressure-induced retinal disorders has not been completely clear.Retinal neurons express pressure-sensitive channels intrinsically sensitive to pressure and membrane stretch,such as the transient receptor potential channel(TRP)family permeable to Ca^2+and Na^+and the two-pore domain K channel family.Recent data have shown that pressure excites the primate retinal bipolar cell by opening TRP vanilloid 4 to mediate transient depolarizing currents,and TRP vanilloid 4 agonists enhance the membrane excitability of primate retinal ganglion cells.The eyeball wall is constructed primarily by the sclera and cornea of low elasticity,and the flow rate of the aqueous humor and intraocular pressure both fluctuate,but the mathematical relationship between the ocular elasticity,aqueous humor volume,and intraocular pressure has not been established.This review will briefly review recent literature on the pressure-related retinal pathophysiology in glaucoma and other pressure-induced retinal disorders,the elasticity of ocular tissues,and pressure-sensitive cation channels in retinal neurons.Emerging data support the global volume and the elasticity and thickness of the sclera and cornea as variables to affect the intraocular pressure level like the volume of the aqueous humor.Recent results also suggest some potential routes for TRPs to mediate retinal ganglion cell dysfunction:TRP opening upon intraocular pressure elevation and membrane stretch,enhancing glutamate release from bipolar cells,increasing intracellular Na^+,Ca^2+concentration in retinal ganglion cells and extracellular glutamate concentration,inactivating voltage-gated Na^+channels,and causing excitotoxicity and dysfunction of retinal ganglion cells.Further studies on these routes likely identify novel targets and therapeutic strategies for the treatment of pressure-induced retinal disorders.
基金Supported by the Leading Innovation Specialist Support Program of Guangdong Provincethe Science and Technology Planning Project of Ganzhou,No.202101074816the National Natural Science Foundation of China,No.82260501.
文摘BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with metastases.The effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain controversial.AIM To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ CC.METHODS This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to 2021.Based on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic control.DFS,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk factors.RESULTS Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.
基金Supported by The National Natural Science Foundation of China,No.82350127 and No.82241013the Shanghai Natural Science Foundation,No.20ZR1411600+2 种基金the Shanghai Shenkang Hospital Development Center,No.SHDC2020CR4039the Bethune Ethicon Excellent Surgery Foundation,No.CESS2021TC04Xuhui District Medical Research Project of Shanghai,No.SHXH201805.
文摘BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.
基金supported by the Postgraduate Scientic Research Innovation Project of Chongqing Normal University(YKC24010)Chunna Zeng's research was supported by the Major Special Project of the National Natural Science Foundation of China(12141101)+2 种基金the Young Top-Talent program of Chongqing(CQYC2021059145)the Technology Research Foundation of Chongqing Educational committee(KJZD-K202200509)the Natural Science Foundation Project of Chongqing(CSTB2024NSCQ-MSX0937)。
文摘Two sharp Chernoff type inequalities are derived for star bodies in R2,one is an extension of the dual Chernoff-Ou-Pan inequality,and the other is the reverse Chernoff type inequality.Furthermore,we establish a generalized dual symmetric mixed Chernoff inequality for two planar star bodies.As a direct consequence,a new proof of the dual symmetric mixed isoperimetric inequality is presented.
文摘Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the Journal of Sport and Health Science,Liang et al.1 describe results from the UK Biobank data showing the benefits of moderate-to-vigorous intensity physical activity(MVPA)on reducing the risks for vascular events in 11,474 adults with T2D and prediabetes.
基金supported by the National Key Research and Development Project (2021YFA1201404)National Natural Science Foundation of China Major Project (81991514)+6 种基金General Project (82272530, 82372459)Jiangsu Province Medical Innovation Center of Orthopedic Surgery (CXZX202214)Jiangsu Provincial Key Medical Center FoundationJiangsu Provincial Medical Outstanding Talent FoundationJiangsu Provincial Medical Youth Talent FoundationJiangsu Provincial Key Medical Talent Foundationthe Fundamental Research Funds for the Central Universities (14380493, 14380494)
文摘Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.
文摘BACKGROUND Type 2 diabetes mellitus(T2DM)often leads to vascular complications,such as albuminuria.The role of insulin autoantibodies(IAA)and their interaction with D-dimer in this context remains unclear.AIM To investigate the characteristics of IAA and its effect on albuminuria in T2DM patients.METHODS We retrospectively analyzed clinical data from 115 T2DM patients with positive IAA induced by exogenous insulin,and 115 age-and sex-matched IAA-negative T2DM patients as controls.Propensity scores were calculated using multivariate logistic regression.Key variables were selected using the least absolute shrinkage and selection operator(LASSO)algorithm.We constructed a prediction model and analyzed the association between IAA and albuminuria based on demographic and laboratory parameters.RESULTS The IAA-positive group had significantly higher D-dimer levels[0.30(0.19-0.55)mg/L vs 0.21(0.19-0.33)mg/L,P=0.008]and plasma insulin levels[39.1(12.0-102.7)μU/mL vs 9.8(5.5-17.6)μU/mL,P<0.001]compared to the IAA-negative group.Increases in the insulin dose per weight ratio,diabetes duration,and urinary albumin-to-creatinine ratio(UACR)were observed but did not reach statistical significance.The LASSO model identified plasma insulin and D-dimer as key factors with larger coefficients.D-dimer was significantly associated with UACR in the total and IAA-positive groups but not in the IAA-negative group.The odds ratio for D-dimer elevation(>0.5 g/L)was 2.88(95%confidence interval:1.17-7.07)in the IAA-positive group(P interaction<0.05).CONCLUSION D-dimer elevation is an independent risk factor for abnormal albuminuria and interacts with IAA in the development of abnormal albuminuria in T2DM patients.
基金supported by the R&D project of Pazhou Lab(Huangpu)under Grant 2023K0610the National Natural Science Foundation of China(Grants 12126602)+4 种基金the National Natural Science Foundation of China(Grants 82030102)the Shenzhen Medical Research Fund(Grants C2302001)the Shenzhen Science and Technology Innovation Committee(No.ZDSYS20200810171403013)the Chinese Postdoctoral Science Foundation(No.2022M721463)the Ministry of Science and Technology of China(Grants 2022YFC3702703).
文摘Objective This study aimed to investigate the impact of glycemic control and diabetes duration on subsequent myocardial infarction(MI)in patients with both coronary heart disease(CHD)and type 2 diabetes(T2D).Methods We conducted a retrospective cohort study of 33,238 patients with both CHD and T2D in Shenzhen,China.Patients were categorized into 6 groups based on baseline fasting plasma glucose(FPG)levels and diabetes duration(from the date of diabetes diagnosis to the baseline date)to examine their combined effects on subsequent MI.Cox proportional hazards regression models were used,with further stratification by age,sex,and comorbidities to assess potential interactions.Results Over a median follow-up of 2.4 years,2,110 patients experienced MI.Compared to those with optimal glycemic control(FPG<6.1 mmol/L)and shorter diabetes duration(<10 years),the fullyadjusted hazard ratio(HR)(95%Confidence Interval[95%CI])for those with a diabetes duration of≥10 years and FPG>8.0 mmol/L was 1.93(95%CI:1.59,2.36).The combined effects of FPG and diabetes duration on MI were largely similar across different age,sex,and comorbidity groups,although the excess risk of MI associated with long-term diabetes appeared to be more pronounced among those with atrial fibrillation.Conclusion Our study indicates that glycemic control and diabetes duration significant influence the subsequent occurrence of MI in patients with both CHD and T2D.Tailored management strategies emphasizing strict glycemic control may be particularly beneficial for patients with longer diabetes duration and atrial fibrillation.
基金supported by the National Natural Science Foundation of China(32161143021)the Iran National Science Foundation(4001873)+1 种基金the Henan Province Natural Science Foundation of China(182300410313)Henan University graduate Talent Program of Henan Province(SYLYC2023092).
文摘Parkinson's disease(PD),a chronic and com-mon neurodegenerative disease,is characterized by the progressive loss of dopaminergic neurons in the dense part of the substantia nigra and abnormal aggregation of alpha-synuclein.Type 2 diabetes mellitus(T2DM)is a metabolic disease characterized by chronic insulin resistance and deficiency in insulin secretion.Extensive evidence has con-firmed shared pathogenic mechanisms underlying PD and T2DM,such as oxidative stress caused by insulin resistance,mitochondrial dysfunction,inflammation,and disorders of energy metabolism.Conventional drugs for treating T2DM,such as metformin and glucagon-like peptide-1 receptor ago-nists,affect nerve repair.Even drugs for treating PD,such as levodopa,can affect insulin secretion.This review sum-marizes the relationship between PD and T2DM and related therapeutic drugs from the perspective of insulin signaling pathways in the brain.
文摘Type 2 diabetes mellitus(T2DM)significantly elevates the risk of colorectal cancer(CRC)and complicates its treatment by promoting chemoresistance.Poor glycemic control has been linked to exacerbated CRC progression and diminished chemotherapy efficacy,impacting patient outcomes through various mechanisms such as oxidative stress,activation of metabolic pathways,and altered protein modifications that hinder apoptosis and enhance tumor survival.Clinical evidence shows that T2DM patients experience higher rates of chemoresistance and reduced disease-free survival and overall survival compared to non-diabetic patients.Specifically,those with poor glycemic control exhibit increased chemo-resistance and poorer survival metrics.Antidiabetic treatments,including metformin,acarbose,and gliclazide,show promise in improving chemotherapy response and glycemic management,potentially enhancing patient outcomes.Addressing this challenge requires a comprehensive,multidisciplinary approach involving oncologists,endocrino-logists,and surgeons to optimize patient care.Integrated strategies that prioritize glycemic control are essential for reducing chemoresistance and improving survival in CRC patients with T2DM.
基金supported by the Capital’s Funds for Health Improvement and Research(No.2024-2G-2118)the National Key Research and Development Program of China(2016YFC1000101)+2 种基金the Leading Talents in the Construction Project of High-Level Public Health Technical Talents in Beijing(2022-1-003)the“Green Seedling”Youth Program by the Beijing Hospitals Authority(QML20231402)the Young Elite Scientist Sponsorship Program by the Beijing Association for Science and Technology(BYESS2022200)。
文摘Objective To investigate the association between ABO blood types and gestational diabetes mellitus(GDM)risk.Methods A prospective birth cohort study was conducted.ABO blood types were determined using the slide method.GDM diagnosis was based on a 75-g,2-h oral glucose tolerance test(OGTT)according to the criteria of the International Association of Diabetes and Pregnancy Study Groups.Logistic regression was applied to calculate the odds ratios(ORs)and 95%confidence intervals(CIs)between ABO blood types and GDM risk.Results A total of 30,740 pregnant women with a mean age of 31.81 years were enrolled in this study.The ABO blood types distribution was:type O(30.99%),type A(26.58%),type B(32.20%),and type AB(10.23%).GDM was identified in 14.44%of participants.Using blood type O as a reference,GDM risk was not significantly higher for types A(OR=1.05)or B(OR=1.04).However,women with type AB had a 19%increased risk of GDM(OR=1.19,95%CI=1.05–1.34;P<0.05),even after adjusting for various factors.This increased risk for type AB was consistent across subgroup and sensitivity analyses.Conclusion The ABO blood types may influence GDM risk,with type AB associated with a higher risk.Incorporating it—either as a single risk factor or in combination with other known factors—could help identify individuals at risk for GDM before or during early pregnancy.
