Let R_1 and R_2 be two rings with unit I. We give some characterizations of ring homomorphisms and ring isomorphisms between R_1 and R_2 in term of complete preservers of fixed points of multipliers, under some mild a...Let R_1 and R_2 be two rings with unit I. We give some characterizations of ring homomorphisms and ring isomorphisms between R_1 and R_2 in term of complete preservers of fixed points of multipliers, under some mild assumption on R_1. Applications to several kinds of operator algebras such as Banach algebras, nest algebras, matrix algebras and standard operator algebras are presented.展开更多
Suppose R is an idempotence-diagonalizable ring. Let n and m be two arbitrary positive integers with n ≥ 3. We denote by Mn（R） the ring of all n x n matrices over R. Let （Jn（R）） be the additive subgroup of Mn（...Suppose R is an idempotence-diagonalizable ring. Let n and m be two arbitrary positive integers with n ≥ 3. We denote by Mn（R） the ring of all n x n matrices over R. Let （Jn（R）） be the additive subgroup of Mn（R） generated additively by all idempotent matrices. Let JJ = （Jn（R）） or Mn（R）. We describe the additive preservers of idempotence from JJ to Mm（R） when 2 is a unit of R. Thereby, we also characterize the Jordan （respectively, ring and ring anti-） homomorphisms from Mn （R） to Mm （R） when 2 is a unit of R.展开更多
Let B（X） be the algebra of all bounded linear operators on an infinite-dimensional complex or real Banach space X. Given an integer n 〉 1, we show that an additive surjective map Ф on B（X） preserves Drazin inver...Let B（X） be the algebra of all bounded linear operators on an infinite-dimensional complex or real Banach space X. Given an integer n 〉 1, we show that an additive surjective map Ф on B（X） preserves Drazin invertible operators of index non-greater than n in both directions if and only if Ф is either of the form Ф（T） = aATA-1 or of the form Ф（T） = aBT＊B-1 where a is a non-zero scalar, A ： X → X and B ： X＊ → X are two bounded invertible linear or conjugate linear operators.展开更多
The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect...The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.展开更多
In this study,composite films consisting of polylactic acid(PLA),ethyl cellulose(EC),and zein were prepared by solution casting method,and their performance and application in chilled fresh meat preservation were inve...In this study,composite films consisting of polylactic acid(PLA),ethyl cellulose(EC),and zein were prepared by solution casting method,and their performance and application in chilled fresh meat preservation were investigated.The results showed that the three materials had satisfactory compatibility in the composite film.Addition of EC and zein effectively improved the mechanical properties,thermodynamic properties,surface hydrophilicity,oxygen permeability,and degradation properties of PLA films.When the ratio of PLA to EC was 3:7,the tensile strength and elongation at break reached maximum values of 16.6 MPa and 30.5%,respectively.Moreover,under different conditions,the composite film exhibited better degradability than the PLA film.The composite film with a 3:7 ratio of PLA to EC had the best performance,with a degradation rate of 21.75%after 84 days.Chilled fresh meat wrapped with the composite film showed significantly improved antioxidant,antibacterial,and water-holding properties.展开更多
Let H be a complex Hilbert space of dimension greater than 2, and B（H） denote the Banach algebra of all bounded linear operators on H. For A, B C B（H）, define the binary relation A ≤ B by A＊A = A＊B and AA＊ = A...Let H be a complex Hilbert space of dimension greater than 2, and B（H） denote the Banach algebra of all bounded linear operators on H. For A, B C B（H）, define the binary relation A ≤ B by A＊A = A＊B and AA＊ = AB＊. Then （B（H）, ＂〈.＂） is a partially ordered set and the relation ＂≤＂ is called the star order on B（H）. Denote by Bs（H） the set of all self-adjoint operators in B（H）. In this paper, we first characterize nonlinear continuous bijective maps on Bs（H） which preserve the star order in both directions. We characterize also additive maps （or linear maps） on B（H） （or nest algebras） which are multiplicative at some invertible operator.展开更多
Chinese President Xi Jinping calls for honoring history to preserve peace,as the country commemorates the 80th anniversary of its hard-won victory in WWII.
In Maizhokunggar County of Lhasa City,the Xizang Autonomous Region,a precious intangible cultural heritage is preserved-the traditional craft of Zaxoi drum making,which carries profound historical and cultural signifi...In Maizhokunggar County of Lhasa City,the Xizang Autonomous Region,a precious intangible cultural heritage is preserved-the traditional craft of Zaxoi drum making,which carries profound historical and cultural significance.After hundreds of years,its unique value continues to shine through the passage of time.For more than 40 years,Kongcho Dondrup,an inheritor of this craftsmanship,has poured his heart into preserving and promoting this ancient art.展开更多
Recent advances in organ transplantation,regenerative medicine,and drug discovery have emphasized the critical importance of effective preservation techniques for organs.Despite these advances,current preservation tec...Recent advances in organ transplantation,regenerative medicine,and drug discovery have emphasized the critical importance of effective preservation techniques for organs.Despite these advances,current preservation techniques have significant limitations in maintaining the viability and functional efficacy of organs over the long term.As a result,there is a pressing need to develop reliable and efficient preservation strategies for organs.Currently,the clinical standard for organ preservation involves the use of static cold storage and organ machine perfusion,but these methods can only preserve organs for a couple of days or even a few hours.Notably,the development of cryobiology has yielded promising alternatives.In this review,we aim to provide a comprehensive overview of the progression of organ preservation methods,while emphasizing the limitations of traditional approaches.Moreover,we evaluate advanced preservation techniques for organs,including kidneys,livers,hearts,lungs,and intestines.Furthermore,we share a progress perspective on the future of organ preservation,with the ultimate goal of achieving viable long-term preservation to address the pressing issue of organ shortage.展开更多
A precious heritage from ancient times,the Beijing-Hangzhou Grand Canal has renewed its former glory through ecological rehabilitation and cultural preservation over the past decades.
There is growing concern about the concept that exposure to environmental chemicals may be contributing to the obesity epidemic.However,there is no consensus on the obesogenic effects of emerging contaminants from a t...There is growing concern about the concept that exposure to environmental chemicals may be contributing to the obesity epidemic.However,there is no consensus on the obesogenic effects of emerging contaminants from a toxicological and environmental perspective.The potential human exposure and experimental evidence for obesogenic effects of emerging contaminants need to be systematically discussed.The main objective of this review is to provide recommendations for further subsequent policy development following a critical analysis of the literature for humans and experimental animals exposed to emerging contaminants.This article reviews human exposure to emerging contaminants(with a focus on antimicrobials,preservatives,water and oil repellents,flame retardants,antibiotics and bisphenols)and the impact of emerging contaminants on obesity.These emerging contaminants have been widely detected in human biological samples.Epidemiological studies provide evidence linking exposure to emerging contaminants to the risks of obesity in humans.Studies based on animalmodels and adipose cells show the obesogenic effects of emerging contaminants and identify modes of action by which contaminants may induce changes in body fat accumulation and lipid metabolic homeostasis.Some knowledge gaps in this area and future directions for further investigation are discussed.展开更多
Mold spoilage and nutrition enrichment are major concerns of Chinese steamed bread,and using functional lactic acid bacteria as starter to play the role of in-situ preservation and nutritional fortification was a prom...Mold spoilage and nutrition enrichment are major concerns of Chinese steamed bread,and using functional lactic acid bacteria as starter to play the role of in-situ preservation and nutritional fortification was a promising alternative.Hence,Lactiplantibacillus plantarum P10 capable of inhibiting spoilage microorganisms and producing γ-aminobutyric acid(GABA)(380 mg/L)was screened from Chinese pickle.Metabolomics analysis showed that P10 produced key antimicrobial metabolites mainly including ten organic acids,aldehyde,alkaloid.Besides,P10 might exhibit health beneficial effects such as degrading cholesterol,lowering blood glucose and reducing uric acid due to the production of deoxycholic acid and Ile-Pro-Ile,and the degradation of purine.Finally,the promising application potential of P10 was evidenced in steamed bread with extended shelf life,excellent anti-aging effect,and 24.5-fold enrichment of GABA.Conclusively,this investigation could provide scientific basis for the application of P10 as a functional starter in steamed bread.展开更多
Decays resulting from infections by Geotrichum citri-aurantii cause a significant reduction in citrus postharvest quality and marketable yield.In the present work,0.8 mol·L^(-1)NaCl of Generally Recognized as Saf...Decays resulting from infections by Geotrichum citri-aurantii cause a significant reduction in citrus postharvest quality and marketable yield.In the present work,0.8 mol·L^(-1)NaCl of Generally Recognized as Safe(GRAS)salts were identified to have complete inhibition activity to G.citriaurantii in vitro and in vivo.An inhibitory mechanism study showed that 0.1 mol·L^(-1)NaCl changed the expression of six genes(Gci002087,Gci003354,Gci000013,Gci000394,Gci003505 and Gci004433)in target of rapamycin(TOR)pathway,thus inducing a large number of lipid droplets(LDs)accumulation with TEM observations and staining.In vivo,0.1 mol·L^(-1)NaCl could raise up the activities of CAT,PAL,PPO and cellulase which hence to strengthen the ability of resistance tolerance of citrus.In addition,NaCl not only accelerated the growth of the biocontrol yeast Kloeckera apiculata strain 34-9,but also increased the expression level of adhesin-encoding genes and biofilm-formation encoding gene(34-9-3691).Finally,the storage experiments in 3 months demonstrated that the combination of NaCl and the yeast 34-9 could keep fresh,reduce decay and prolong its shelf-life,thus implying that the combination of biocontrol strain and GRAS salts has been explored as a promising alternative to synthetic fungicides.展开更多
Premature ovarian insufficiency(POI)caused by chemotherapy is a common complication in female cancer survivors of childbearing age.Traditional methods,including mesenchymal stem cell(MSC)transplant and hormone replace...Premature ovarian insufficiency(POI)caused by chemotherapy is a common complication in female cancer survivors of childbearing age.Traditional methods,including mesenchymal stem cell(MSC)transplant and hormone replacement therapy,have limited clinical application because of their drawbacks,and more methods need to be developed.In the current study,the potential effects and underlying mechanisms of human umbilical cord MSC-derived extracellular vesicles(h UCMSC-EVs)were investigated in a cisplatin(CDDP)-induced POI mouse model and a human granulosa cell(GC)line.The results showed that h UCMSC-EVs significantly attenuated body weight loss,ovarian weight loss,ovary atrophy,and follicle loss in moderate-dose(1.5 mg/kg)CDDP-induced POI mice,similar to the effects observed with h UCMSCs.We further found that the h UCMSCEVs inhibited CDDP-induced ovarian GC apoptosis by upregulating anti-apoptotic mi RNA levels in GCs,thereby downregulating the m RNA levels of multiple pro-apoptotic genes.In general,our findings indicate that the moderate-dose chemotherapy may be a better choice for clinical oncotherapy,considering effective rescue of the oncotherapy-induced ovarian damage with h UCMSC-EVs.Additionally,multiple mi RNAs in h UCMSC-EVs may potentially be used to inhibit the chemotherapy-induced ovarian GC apoptosis,thereby restoring ovarian function and improving the life quality of female cancer patients.展开更多
AIM:To evaluate clinical characteristics,treatment patterns and long-term quality of life(QoL)among children with retinoblastoma(RB)managed at a single tertiary center in China.METHODS:Totally 62 consecutive patients(...AIM:To evaluate clinical characteristics,treatment patterns and long-term quality of life(QoL)among children with retinoblastoma(RB)managed at a single tertiary center in China.METHODS:Totally 62 consecutive patients(71 eyes)diagnosed with RB were retrospectively reviewed.The mean age at first visit was 22.13±17.87mo;35(56.45%)were male.Unilateral disease occurred in 53 patients(85.48%)and bilateral disease in 9(14.52%).According to the international intraocular retinoblastoma classification(IIRC),eyes were staged as A(n=6),B(n=9),C(n=9),D(n=21),E(n=19),and extraocular(n=7).Treatments followed stagebased indications.QoL at follow-up was assessed using validated pediatric ophthalmic instruments completed by patients and/or parents.RESULTS:The mean follow-up duration was 42.9±6.49mo.Overall survival was 90.32%(56/62),mortality was 9.68%(6/62).The overall globe-preservation rate was 64.79%(46/71),and 71.88%(46/64)for intraocular RB.Eye salvage by IIRC stage was 100%for A–C,71.43%(15/21)for D,and 36.84%(7/19)for E;no eyes were preserved in extraocular disease.Compared with the globe-preservation group,enucleated children had significantly lower scores in appearance,social functioning,and role domains on QoL measures(P<0.05).Across all PedEyeQ domains,children with preserved globes scored higher than those who underwent enucleation(P<0.05).CONCLUSION:Most children in this cohort present with intermediate-to-advanced disease,which limit eyepreservation opportunities.While survival approached contemporary benchmarks,QoL deficits are most pronounced in appearance,social participation,and role functioning after enucleation.Additionally,parents of children who underwent enucleation often experience heightened anxiety about their child’s vision and social integration.These findings underscore the need for earlier detection and integrated psychosocial support alongside stage-appropriate therapy.展开更多
Background Organic acids(OA)and maternal nutritional strategies have been demonstrated to promote piglet health and development.The objective of this study was to investigate the effects of incorporating OA-preserved ...Background Organic acids(OA)and maternal nutritional strategies have been demonstrated to promote piglet health and development.The objective of this study was to investigate the effects of incorporating OA-preserved cereal grains into sow diets during late gestation and lactation,aiming to reduce the metabolic demands of lactation while optimising offspring development and growth until slaughter.The experiment compared OA-preserved wheat and barley to conventionally dried grains,focusing on sow and offspring performance,as well as their faecal microbiota during lactation.Forty sows were blocked based on parity,body weight and back fat thickness on d 100 of gestation and assigned to one of two diets:a dried grain lactation diet and a preserved grain lactation diet.Sow faecal samples were collected at farrowing for the coefficient of apparent total tract digestibility(CATTD)of nutrients and microbial analysis.Offspring faecal samples were collected on d 10 postpartum and at weaning(d 26 postpartum)for microbial analysis.Results Sow body weight,back fat changes,gestation and lactation length,total piglets born,wean-to-oestrus interval,and lactation efficiency were unaffected by sow diet(P>0.05).However,sows offered the preserved grain diet exhibited improved CATTD of dry matter,nitrogen,gross energy,and neutral detergent fibre(P<0.05).While no maternal effect was observed on offspring growth during lactation(P>0.05),pigs from sows offered the preserved grain diet showed improved growth and feed efficiency from weaning until slaughter(d 168)compared to those from sows offered the dried grain diet(P<0.05).The preserved grain diet also reduced the abundance of Proteobacteria in sow faeces at farrowing and in their offspring on d 10 postpartum,and improved piglet faecal scores throughout lactation(P=0.05).At weaning,piglets from sows offered the preserved grain diet exhibited an increased abundance of Lactobacillus and reduced abundance of Alistipes in their faeces(P<0.05).Conclusion OA-preserved grains enhanced the CATTD of nutrients in sows,promoted healthier piglet faecal scores during lactation,and improved offspring growth performance post-weaning,potentially linked to beneficial changes observed in the faecal microbiota of sows and their offspring during lactation.展开更多
This study investigates community identity in Nanjing’s historic Hehuatang community during urban renewal,revealing tensions between heritage preservation and modernization.Through ethnographic research,three key fac...This study investigates community identity in Nanjing’s historic Hehuatang community during urban renewal,revealing tensions between heritage preservation and modernization.Through ethnographic research,three key factors are identified shaping identity:(i)material conditions including series of spatial conflicts around overcrowding,(ii)social tensions such as tenant-aborigine divides and generational misunderstanding,and(iii)institutional governance as top-down policies would exacerbate distrust.Despite 82%of residents expressing place attachment,67%desire relocation due to deteriorating liveability—a paradox highlighting the failure of China’s contemporary performative participation models.The adapted three-layer creativity model underscores the need to reconcile physical renewal with social equity.Findings advocate for co-design processes that integrate resident agency,offering lessons for sustainable urban renewal in rapidly developing contexts.展开更多
Gabon,located on the west coast of Central Africa,is one of the most forested countries.This small but richly biodiverse country is covered by rainforests,which make up approximately 85%of its land area.These forests ...Gabon,located on the west coast of Central Africa,is one of the most forested countries.This small but richly biodiverse country is covered by rainforests,which make up approximately 85%of its land area.These forests are home to a wide variety of wildlife,including elephants and numerous bird species,making Gabon a crucial area for conservation efforts.展开更多
The thioacetamide derivative(TD)-composite preservation system(TDCPS)exhibits superior preservation effects on natural rubber latex(NRL)and significantly enhances its vulcanization efficiency and mechanical properties...The thioacetamide derivative(TD)-composite preservation system(TDCPS)exhibits superior preservation effects on natural rubber latex(NRL)and significantly enhances its vulcanization efficiency and mechanical properties.This study primarily investigated the principal chemical groups and mechanism of action of TDCPS in promoting NRL vulcanization through a comparative analysis.The results indicated that the key functional groups(thioamide and pyridine)in TDCPS synergistically accelerated crosslinking,reducing the vulcanization time by 41.18%compared to the high-ammonia(HA)preservation system.At an optimal TDCPS dosage of 5 mmol·L^(−1),vulcanized films achieved a tensile strength of 34.18 MPa,with a sulfur content of 1.5 phr further improving the strength by 42.26%.TD outperformed the conventional accelerators 2-imidazolidinethione(ETU)and 3-hydroxypyridine(3-Hp)in promoting the crosslinking density and mechanical performance while eliminating ammonia-related environmental risks.This eco-friendly system demonstrates the industrial potential for sustainable rubber production.展开更多
Habit formation is essential for environmental preservation and sustainability as it promotes consistent,long-term engagement in pro-environmental behaviors.Habitual pro-environmental behaviors contribute to the estab...Habit formation is essential for environmental preservation and sustainability as it promotes consistent,long-term engagement in pro-environmental behaviors.Habitual pro-environmental behaviors contribute to the establishment of social norms,encouraging communities to adopt sustainable lifestyles collectively.As more people integrate environmentally conscious practices into their daily routines,the broader cultural shift toward sustainability becomes more pronounced.This paper explored the experiences of environmental advocates of sustainability,emphasizing habit formation as a fundamental driver of long-term ecological responsibility.Environmental advocates(n=20)from the Visayas,Philippines,were purposively sampled for interviews.Participants expressed a deep personal commitment to sustainability as a lifelong responsibility.Participants actively promoted sustainability through education,advocating for responsible consumption,and participating in community-driven environmental initiatives.When individuals develop habits such as energy conservation,waste reduction,and responsible consumption,these actions become second nature,requiring minimal cognitive effort to sustain over time.This consistency is vital in addressing environmental challenges,as one-time actions are insufficient to create lasting change.Collaborative initiatives,community engagement,and institutional support are essential for achieving lasting environmental impact.Nevertheless,the findings can inform educational programs,policy-making,and community-driven sustainability initiatives,reinforcing the idea that both individual actions and collective efforts are necessary to address environmental challenges effectively.展开更多
基金Supported by the National Natural Science Foundation of China(Grant No.11671294)
文摘Let R_1 and R_2 be two rings with unit I. We give some characterizations of ring homomorphisms and ring isomorphisms between R_1 and R_2 in term of complete preservers of fixed points of multipliers, under some mild assumption on R_1. Applications to several kinds of operator algebras such as Banach algebras, nest algebras, matrix algebras and standard operator algebras are presented.
基金This work is supported in part by the Chinese Natural Science Foundation under Grant No. 10671026 and the Postdoctoral Fund of Heilongjiang Province
文摘Suppose R is an idempotence-diagonalizable ring. Let n and m be two arbitrary positive integers with n ≥ 3. We denote by Mn（R） the ring of all n x n matrices over R. Let （Jn（R）） be the additive subgroup of Mn（R） generated additively by all idempotent matrices. Let JJ = （Jn（R）） or Mn（R）. We describe the additive preservers of idempotence from JJ to Mm（R） when 2 is a unit of R. Thereby, we also characterize the Jordan （respectively, ring and ring anti-） homomorphisms from Mn （R） to Mm （R） when 2 is a unit of R.
文摘Let B（X） be the algebra of all bounded linear operators on an infinite-dimensional complex or real Banach space X. Given an integer n 〉 1, we show that an additive surjective map Ф on B（X） preserves Drazin invertible operators of index non-greater than n in both directions if and only if Ф is either of the form Ф（T） = aATA-1 or of the form Ф（T） = aBT＊B-1 where a is a non-zero scalar, A ： X → X and B ： X＊ → X are two bounded invertible linear or conjugate linear operators.
文摘The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.
文摘In this study,composite films consisting of polylactic acid(PLA),ethyl cellulose(EC),and zein were prepared by solution casting method,and their performance and application in chilled fresh meat preservation were investigated.The results showed that the three materials had satisfactory compatibility in the composite film.Addition of EC and zein effectively improved the mechanical properties,thermodynamic properties,surface hydrophilicity,oxygen permeability,and degradation properties of PLA films.When the ratio of PLA to EC was 3:7,the tensile strength and elongation at break reached maximum values of 16.6 MPa and 30.5%,respectively.Moreover,under different conditions,the composite film exhibited better degradability than the PLA film.The composite film with a 3:7 ratio of PLA to EC had the best performance,with a degradation rate of 21.75%after 84 days.Chilled fresh meat wrapped with the composite film showed significantly improved antioxidant,antibacterial,and water-holding properties.
基金Supported by National Natural Science Foundation of China （Grant Nos. 10871111, 10501029） and the Specialized Research Fund for Doctoral Program of Higher Education （Grant No. 200800030059）
文摘Let H be a complex Hilbert space of dimension greater than 2, and B（H） denote the Banach algebra of all bounded linear operators on H. For A, B C B（H）, define the binary relation A ≤ B by A＊A = A＊B and AA＊ = AB＊. Then （B（H）, ＂〈.＂） is a partially ordered set and the relation ＂≤＂ is called the star order on B（H）. Denote by Bs（H） the set of all self-adjoint operators in B（H）. In this paper, we first characterize nonlinear continuous bijective maps on Bs（H） which preserve the star order in both directions. We characterize also additive maps （or linear maps） on B（H） （or nest algebras） which are multiplicative at some invertible operator.
文摘Chinese President Xi Jinping calls for honoring history to preserve peace,as the country commemorates the 80th anniversary of its hard-won victory in WWII.
文摘In Maizhokunggar County of Lhasa City,the Xizang Autonomous Region,a precious intangible cultural heritage is preserved-the traditional craft of Zaxoi drum making,which carries profound historical and cultural significance.After hundreds of years,its unique value continues to shine through the passage of time.For more than 40 years,Kongcho Dondrup,an inheritor of this craftsmanship,has poured his heart into preserving and promoting this ancient art.
基金financially supported by the National Key Research and Development Program of China(2022YFC2100800)the National Natural Science Foundation of China(22478296,22078238,52373117,and U23B20121)+1 种基金the Haihe Laboratory of Sustainable Chemical Transformations(24HHWCSS00005)the Open Funding Project of the National Key Laboratory of Biochemical Engineering。
文摘Recent advances in organ transplantation,regenerative medicine,and drug discovery have emphasized the critical importance of effective preservation techniques for organs.Despite these advances,current preservation techniques have significant limitations in maintaining the viability and functional efficacy of organs over the long term.As a result,there is a pressing need to develop reliable and efficient preservation strategies for organs.Currently,the clinical standard for organ preservation involves the use of static cold storage and organ machine perfusion,but these methods can only preserve organs for a couple of days or even a few hours.Notably,the development of cryobiology has yielded promising alternatives.In this review,we aim to provide a comprehensive overview of the progression of organ preservation methods,while emphasizing the limitations of traditional approaches.Moreover,we evaluate advanced preservation techniques for organs,including kidneys,livers,hearts,lungs,and intestines.Furthermore,we share a progress perspective on the future of organ preservation,with the ultimate goal of achieving viable long-term preservation to address the pressing issue of organ shortage.
文摘A precious heritage from ancient times,the Beijing-Hangzhou Grand Canal has renewed its former glory through ecological rehabilitation and cultural preservation over the past decades.
基金supported by the National Key Research&Development Programof China,Ministry of Science and Technology(Nos.2022YFE0134900 and 2022YFC3703200)the Key Research and Development Programof Zhejiang Province,China(No.2024C03228)the National Nature Science Foundation of China(Nos.22376184 and 22076166).
文摘There is growing concern about the concept that exposure to environmental chemicals may be contributing to the obesity epidemic.However,there is no consensus on the obesogenic effects of emerging contaminants from a toxicological and environmental perspective.The potential human exposure and experimental evidence for obesogenic effects of emerging contaminants need to be systematically discussed.The main objective of this review is to provide recommendations for further subsequent policy development following a critical analysis of the literature for humans and experimental animals exposed to emerging contaminants.This article reviews human exposure to emerging contaminants(with a focus on antimicrobials,preservatives,water and oil repellents,flame retardants,antibiotics and bisphenols)and the impact of emerging contaminants on obesity.These emerging contaminants have been widely detected in human biological samples.Epidemiological studies provide evidence linking exposure to emerging contaminants to the risks of obesity in humans.Studies based on animalmodels and adipose cells show the obesogenic effects of emerging contaminants and identify modes of action by which contaminants may induce changes in body fat accumulation and lipid metabolic homeostasis.Some knowledge gaps in this area and future directions for further investigation are discussed.
基金financially supported by Natural Science Foundations of Hebei Province(C2022208003)Youth Top Talent Plan in Hebei Province。
文摘Mold spoilage and nutrition enrichment are major concerns of Chinese steamed bread,and using functional lactic acid bacteria as starter to play the role of in-situ preservation and nutritional fortification was a promising alternative.Hence,Lactiplantibacillus plantarum P10 capable of inhibiting spoilage microorganisms and producing γ-aminobutyric acid(GABA)(380 mg/L)was screened from Chinese pickle.Metabolomics analysis showed that P10 produced key antimicrobial metabolites mainly including ten organic acids,aldehyde,alkaloid.Besides,P10 might exhibit health beneficial effects such as degrading cholesterol,lowering blood glucose and reducing uric acid due to the production of deoxycholic acid and Ile-Pro-Ile,and the degradation of purine.Finally,the promising application potential of P10 was evidenced in steamed bread with extended shelf life,excellent anti-aging effect,and 24.5-fold enrichment of GABA.Conclusively,this investigation could provide scientific basis for the application of P10 as a functional starter in steamed bread.
基金supported by the National Natural Science Foundation of China(Grant Nos.32302170&32172255)HZAU-AGIS Cooperation Fund(Grant No.SZYJY2023001)。
文摘Decays resulting from infections by Geotrichum citri-aurantii cause a significant reduction in citrus postharvest quality and marketable yield.In the present work,0.8 mol·L^(-1)NaCl of Generally Recognized as Safe(GRAS)salts were identified to have complete inhibition activity to G.citriaurantii in vitro and in vivo.An inhibitory mechanism study showed that 0.1 mol·L^(-1)NaCl changed the expression of six genes(Gci002087,Gci003354,Gci000013,Gci000394,Gci003505 and Gci004433)in target of rapamycin(TOR)pathway,thus inducing a large number of lipid droplets(LDs)accumulation with TEM observations and staining.In vivo,0.1 mol·L^(-1)NaCl could raise up the activities of CAT,PAL,PPO and cellulase which hence to strengthen the ability of resistance tolerance of citrus.In addition,NaCl not only accelerated the growth of the biocontrol yeast Kloeckera apiculata strain 34-9,but also increased the expression level of adhesin-encoding genes and biofilm-formation encoding gene(34-9-3691).Finally,the storage experiments in 3 months demonstrated that the combination of NaCl and the yeast 34-9 could keep fresh,reduce decay and prolong its shelf-life,thus implying that the combination of biocontrol strain and GRAS salts has been explored as a promising alternative to synthetic fungicides.
基金Financial support for the current study was provided by the grant from"Blue Engineering"Excellent Young Teacher Foundation in Colleges and Universities of Jiangsu Province(Grant No.KY101R202207 to Xiaojun Chen)。
文摘Premature ovarian insufficiency(POI)caused by chemotherapy is a common complication in female cancer survivors of childbearing age.Traditional methods,including mesenchymal stem cell(MSC)transplant and hormone replacement therapy,have limited clinical application because of their drawbacks,and more methods need to be developed.In the current study,the potential effects and underlying mechanisms of human umbilical cord MSC-derived extracellular vesicles(h UCMSC-EVs)were investigated in a cisplatin(CDDP)-induced POI mouse model and a human granulosa cell(GC)line.The results showed that h UCMSC-EVs significantly attenuated body weight loss,ovarian weight loss,ovary atrophy,and follicle loss in moderate-dose(1.5 mg/kg)CDDP-induced POI mice,similar to the effects observed with h UCMSCs.We further found that the h UCMSCEVs inhibited CDDP-induced ovarian GC apoptosis by upregulating anti-apoptotic mi RNA levels in GCs,thereby downregulating the m RNA levels of multiple pro-apoptotic genes.In general,our findings indicate that the moderate-dose chemotherapy may be a better choice for clinical oncotherapy,considering effective rescue of the oncotherapy-induced ovarian damage with h UCMSC-EVs.Additionally,multiple mi RNAs in h UCMSC-EVs may potentially be used to inhibit the chemotherapy-induced ovarian GC apoptosis,thereby restoring ovarian function and improving the life quality of female cancer patients.
基金Supported by The Key Research and Development Program of Hubei Province(No.2022BCA044)The Key Scientific Research Program of Health Commission of Hubei Province(No.WJ2023Z006).
文摘AIM:To evaluate clinical characteristics,treatment patterns and long-term quality of life(QoL)among children with retinoblastoma(RB)managed at a single tertiary center in China.METHODS:Totally 62 consecutive patients(71 eyes)diagnosed with RB were retrospectively reviewed.The mean age at first visit was 22.13±17.87mo;35(56.45%)were male.Unilateral disease occurred in 53 patients(85.48%)and bilateral disease in 9(14.52%).According to the international intraocular retinoblastoma classification(IIRC),eyes were staged as A(n=6),B(n=9),C(n=9),D(n=21),E(n=19),and extraocular(n=7).Treatments followed stagebased indications.QoL at follow-up was assessed using validated pediatric ophthalmic instruments completed by patients and/or parents.RESULTS:The mean follow-up duration was 42.9±6.49mo.Overall survival was 90.32%(56/62),mortality was 9.68%(6/62).The overall globe-preservation rate was 64.79%(46/71),and 71.88%(46/64)for intraocular RB.Eye salvage by IIRC stage was 100%for A–C,71.43%(15/21)for D,and 36.84%(7/19)for E;no eyes were preserved in extraocular disease.Compared with the globe-preservation group,enucleated children had significantly lower scores in appearance,social functioning,and role domains on QoL measures(P<0.05).Across all PedEyeQ domains,children with preserved globes scored higher than those who underwent enucleation(P<0.05).CONCLUSION:Most children in this cohort present with intermediate-to-advanced disease,which limit eyepreservation opportunities.While survival approached contemporary benchmarks,QoL deficits are most pronounced in appearance,social participation,and role functioning after enucleation.Additionally,parents of children who underwent enucleation often experience heightened anxiety about their child’s vision and social integration.These findings underscore the need for earlier detection and integrated psychosocial support alongside stage-appropriate therapy.
基金funded by the Science Foundation Ireland(BiOrbic,Dublin,Ireland)and Adesco Nutricines(Dungarvan,Waterford,Ireland)under grant number 16/RC/3889。
文摘Background Organic acids(OA)and maternal nutritional strategies have been demonstrated to promote piglet health and development.The objective of this study was to investigate the effects of incorporating OA-preserved cereal grains into sow diets during late gestation and lactation,aiming to reduce the metabolic demands of lactation while optimising offspring development and growth until slaughter.The experiment compared OA-preserved wheat and barley to conventionally dried grains,focusing on sow and offspring performance,as well as their faecal microbiota during lactation.Forty sows were blocked based on parity,body weight and back fat thickness on d 100 of gestation and assigned to one of two diets:a dried grain lactation diet and a preserved grain lactation diet.Sow faecal samples were collected at farrowing for the coefficient of apparent total tract digestibility(CATTD)of nutrients and microbial analysis.Offspring faecal samples were collected on d 10 postpartum and at weaning(d 26 postpartum)for microbial analysis.Results Sow body weight,back fat changes,gestation and lactation length,total piglets born,wean-to-oestrus interval,and lactation efficiency were unaffected by sow diet(P>0.05).However,sows offered the preserved grain diet exhibited improved CATTD of dry matter,nitrogen,gross energy,and neutral detergent fibre(P<0.05).While no maternal effect was observed on offspring growth during lactation(P>0.05),pigs from sows offered the preserved grain diet showed improved growth and feed efficiency from weaning until slaughter(d 168)compared to those from sows offered the dried grain diet(P<0.05).The preserved grain diet also reduced the abundance of Proteobacteria in sow faeces at farrowing and in their offspring on d 10 postpartum,and improved piglet faecal scores throughout lactation(P=0.05).At weaning,piglets from sows offered the preserved grain diet exhibited an increased abundance of Lactobacillus and reduced abundance of Alistipes in their faeces(P<0.05).Conclusion OA-preserved grains enhanced the CATTD of nutrients in sows,promoted healthier piglet faecal scores during lactation,and improved offspring growth performance post-weaning,potentially linked to beneficial changes observed in the faecal microbiota of sows and their offspring during lactation.
基金Sponsored by The National Social Science Fundation of China(24BGL216).
文摘This study investigates community identity in Nanjing’s historic Hehuatang community during urban renewal,revealing tensions between heritage preservation and modernization.Through ethnographic research,three key factors are identified shaping identity:(i)material conditions including series of spatial conflicts around overcrowding,(ii)social tensions such as tenant-aborigine divides and generational misunderstanding,and(iii)institutional governance as top-down policies would exacerbate distrust.Despite 82%of residents expressing place attachment,67%desire relocation due to deteriorating liveability—a paradox highlighting the failure of China’s contemporary performative participation models.The adapted three-layer creativity model underscores the need to reconcile physical renewal with social equity.Findings advocate for co-design processes that integrate resident agency,offering lessons for sustainable urban renewal in rapidly developing contexts.
文摘Gabon,located on the west coast of Central Africa,is one of the most forested countries.This small but richly biodiverse country is covered by rainforests,which make up approximately 85%of its land area.These forests are home to a wide variety of wildlife,including elephants and numerous bird species,making Gabon a crucial area for conservation efforts.
基金the Ministry of Agriculture and Rural Affairs of Chinathe Department of Science and Technology of the Hainan Province for their support+2 种基金financially supported by the National Key R&D Program of China(No. 2022YFD2301201)Hainan Province Science and Technology Special Fund (No. ZDYF2024XDNY284)Earmarked Fund for China Agriculture Research System (No.CARS-33-JG1)
文摘The thioacetamide derivative(TD)-composite preservation system(TDCPS)exhibits superior preservation effects on natural rubber latex(NRL)and significantly enhances its vulcanization efficiency and mechanical properties.This study primarily investigated the principal chemical groups and mechanism of action of TDCPS in promoting NRL vulcanization through a comparative analysis.The results indicated that the key functional groups(thioamide and pyridine)in TDCPS synergistically accelerated crosslinking,reducing the vulcanization time by 41.18%compared to the high-ammonia(HA)preservation system.At an optimal TDCPS dosage of 5 mmol·L^(−1),vulcanized films achieved a tensile strength of 34.18 MPa,with a sulfur content of 1.5 phr further improving the strength by 42.26%.TD outperformed the conventional accelerators 2-imidazolidinethione(ETU)and 3-hydroxypyridine(3-Hp)in promoting the crosslinking density and mechanical performance while eliminating ammonia-related environmental risks.This eco-friendly system demonstrates the industrial potential for sustainable rubber production.
文摘Habit formation is essential for environmental preservation and sustainability as it promotes consistent,long-term engagement in pro-environmental behaviors.Habitual pro-environmental behaviors contribute to the establishment of social norms,encouraging communities to adopt sustainable lifestyles collectively.As more people integrate environmentally conscious practices into their daily routines,the broader cultural shift toward sustainability becomes more pronounced.This paper explored the experiences of environmental advocates of sustainability,emphasizing habit formation as a fundamental driver of long-term ecological responsibility.Environmental advocates(n=20)from the Visayas,Philippines,were purposively sampled for interviews.Participants expressed a deep personal commitment to sustainability as a lifelong responsibility.Participants actively promoted sustainability through education,advocating for responsible consumption,and participating in community-driven environmental initiatives.When individuals develop habits such as energy conservation,waste reduction,and responsible consumption,these actions become second nature,requiring minimal cognitive effort to sustain over time.This consistency is vital in addressing environmental challenges,as one-time actions are insufficient to create lasting change.Collaborative initiatives,community engagement,and institutional support are essential for achieving lasting environmental impact.Nevertheless,the findings can inform educational programs,policy-making,and community-driven sustainability initiatives,reinforcing the idea that both individual actions and collective efforts are necessary to address environmental challenges effectively.
