Emulsions are inherently thermodynamically unstable dispersions that are widely involved in food processing,cosmetic preparation,and drug delivery.The existing ultrasonic emulsification techniques mainly rely on the d...Emulsions are inherently thermodynamically unstable dispersions that are widely involved in food processing,cosmetic preparation,and drug delivery.The existing ultrasonic emulsification techniques mainly rely on the direct contact between the sonicator probe and liquids,which causes localized high temperature and pressure within the liquid and influences the final properties of the obtained emulsion.In this work,a containerless emulsification approach has been realized by using ultrasonic levitation.The emulsification of water‒oil system can be promoted by adjusting the emitter‒reflector distance to alter the acoustic radiation pressure on the surface of the levitated drop.The dynamic behaviors of the emulsification process were monitored by using a high-speed camera,and the sound field was analyzed via numerical simu-lation.The experimental results showed that atomization of droplets driven by sound field was the main driving force for emulsification.This method can be used to pre-pare emulsions in which the average diameter of the droplets was about 2–3µm.The work provided a new method for containerless emulsification,thus shedding light on the preparation of contamination-free pharmaceuticals.展开更多
Objective To explore the efficacy of linaclotide combined with compound polyethylene glycol(PEG)on bowel preparation,and compare it with traditional PEG 3 L and oral sulfate solution(OSS)3 L methods.Methods Patients a...Objective To explore the efficacy of linaclotide combined with compound polyethylene glycol(PEG)on bowel preparation,and compare it with traditional PEG 3 L and oral sulfate solution(OSS)3 L methods.Methods Patients aged 18-70 years who underwent colonoscopy attheDigestiveDiseases Hospital,Heilongjiang Provincial Hospital from January to June 2023 were continuously enrolled in the randomized controlled trial and randomly divided into 3 groups using the random number table.Intestinal preparation was conducted according to the protocols of each group,Group A:3 L PEG;Group B:3 L OSS;Group C:290μg of linaclotide+2 L PEG.The effects of bowel preparation,adverse reactions,satisfaction,and willingnesssfor repeated bowel preparation were compared.Results A total of 360 patients were included in the analysis,with 120 patients in each group.There were no statistically significant differences in the median Boston bowel preparation score for each intestinal segment or the total score among the 3 groups(left colon:3 VS 2 VS 3,H=0.371,P=0.831;transverse colon:3 VS 3 VS 3,H=0.487,P=0.784;right colon:2VS 2VS 2,H=1.088,P=0.580;total score:8 VS 8 VS 8,H=0.017,P=0.991).Among the adverse reactions,the incidence of nausea and vomiting in Group B[3.33%(4/120)]was lower than that in Group A[12.50%(15/120),x^(2)=8.042,P=0.018],and there were no statistically significant differences in other adverse reactions among the 3 groups(P>0.05).There was no significant difference in the satisfaction level among the 3 groups(x^(2)=11.840,P=0.158).The willingness to undergo bowel preparation again in Group C[95.83%(115/120)]and Group B[96.67%(116/120)w]as higher than that in Group A[85.00%(102/120)](Group C VS Group A:x^(2)=8.127,P=0.004;Group B VS Group A:X=9.808,P=0.002),and there was no significant difference between Group C and B(x^(2)=0.000,P=1.000).Conclusion Linaclotide combined with 2 L PEG offers comparable bowel preparation efficacy and safety to 3 L PEG or 3 L OSS,with improved patient compliance due to reduced water intake,suggesting its potential as an enhanced bowel preparation regimen.展开更多
基金National Natural Science Foundation of China,Grant/Award Numbers:12272314,11972303State Key Laboratory of Solidification Processing,Northwestern Polytechnical University,Grant/Award Number:SKLSP202001。
文摘Emulsions are inherently thermodynamically unstable dispersions that are widely involved in food processing,cosmetic preparation,and drug delivery.The existing ultrasonic emulsification techniques mainly rely on the direct contact between the sonicator probe and liquids,which causes localized high temperature and pressure within the liquid and influences the final properties of the obtained emulsion.In this work,a containerless emulsification approach has been realized by using ultrasonic levitation.The emulsification of water‒oil system can be promoted by adjusting the emitter‒reflector distance to alter the acoustic radiation pressure on the surface of the levitated drop.The dynamic behaviors of the emulsification process were monitored by using a high-speed camera,and the sound field was analyzed via numerical simu-lation.The experimental results showed that atomization of droplets driven by sound field was the main driving force for emulsification.This method can be used to pre-pare emulsions in which the average diameter of the droplets was about 2–3µm.The work provided a new method for containerless emulsification,thus shedding light on the preparation of contamination-free pharmaceuticals.
文摘Objective To explore the efficacy of linaclotide combined with compound polyethylene glycol(PEG)on bowel preparation,and compare it with traditional PEG 3 L and oral sulfate solution(OSS)3 L methods.Methods Patients aged 18-70 years who underwent colonoscopy attheDigestiveDiseases Hospital,Heilongjiang Provincial Hospital from January to June 2023 were continuously enrolled in the randomized controlled trial and randomly divided into 3 groups using the random number table.Intestinal preparation was conducted according to the protocols of each group,Group A:3 L PEG;Group B:3 L OSS;Group C:290μg of linaclotide+2 L PEG.The effects of bowel preparation,adverse reactions,satisfaction,and willingnesssfor repeated bowel preparation were compared.Results A total of 360 patients were included in the analysis,with 120 patients in each group.There were no statistically significant differences in the median Boston bowel preparation score for each intestinal segment or the total score among the 3 groups(left colon:3 VS 2 VS 3,H=0.371,P=0.831;transverse colon:3 VS 3 VS 3,H=0.487,P=0.784;right colon:2VS 2VS 2,H=1.088,P=0.580;total score:8 VS 8 VS 8,H=0.017,P=0.991).Among the adverse reactions,the incidence of nausea and vomiting in Group B[3.33%(4/120)]was lower than that in Group A[12.50%(15/120),x^(2)=8.042,P=0.018],and there were no statistically significant differences in other adverse reactions among the 3 groups(P>0.05).There was no significant difference in the satisfaction level among the 3 groups(x^(2)=11.840,P=0.158).The willingness to undergo bowel preparation again in Group C[95.83%(115/120)]and Group B[96.67%(116/120)w]as higher than that in Group A[85.00%(102/120)](Group C VS Group A:x^(2)=8.127,P=0.004;Group B VS Group A:X=9.808,P=0.002),and there was no significant difference between Group C and B(x^(2)=0.000,P=1.000).Conclusion Linaclotide combined with 2 L PEG offers comparable bowel preparation efficacy and safety to 3 L PEG or 3 L OSS,with improved patient compliance due to reduced water intake,suggesting its potential as an enhanced bowel preparation regimen.
