The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_(2)CsSb photocathode has th...The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_(2)CsSb photocathode has the advantages of high quantum efficiency, long lifetime and instantaneous response. This study introduces the design of a set of K_(2)CsSb photocathode preparation systems and detailed preparation process of K_(2)CsSb photocathodes, including sequential deposition process and co-deposition process, and finally develops a K_(2)CsSb photocathode. The influence of laser power on the quantum efficiency is also investigated.展开更多
Well-crystallized Nd2O3 nanorods were prepared in the aqueous solution containing neodymium nitrate, sodium hydroxide（dissolved in ethanol） and sodium dodecyl benzene sulfonate（SDBS）. One dimensional nanorods of n...Well-crystallized Nd2O3 nanorods were prepared in the aqueous solution containing neodymium nitrate, sodium hydroxide（dissolved in ethanol） and sodium dodecyl benzene sulfonate（SDBS）. One dimensional nanorods of neodymium hydroxide were synthesized first, which was then placed at different temperatures（600 and 800 ℃） in a calcar for 10 h to form Nd2O3 nanorods. The morphology and crystal structure of the products were investigated by X-ray diffraction, transmission electron microscopy, field emission transmission electron microscopy, Fourier transform infrared spectroscopy and fluorescence spectrometry. By using SDBS micelles as a template, this method manufactured uniform morphology of hexagonal one-dimensional neodymium oxide nanorods with a diameter ranging from 20 to 70 nm. The length of the nanorods increased with prolonged reaction time.展开更多
In this paper, the control laws based on the Lyapunov stability theorem are designed for a two-level open quantum system to prepare the Hadamard gate, which is an important basic gate for the quantum computers. First,...In this paper, the control laws based on the Lyapunov stability theorem are designed for a two-level open quantum system to prepare the Hadamard gate, which is an important basic gate for the quantum computers. First, the density matrix interested in quantum system is transferred to vector formation.Then, in order to obtain a controller with higher accuracy and faster convergence rate, a Lyapunov function based on the matrix logarithm function is designed. After that, a procedure for the controller design is derived based on the Lyapunov stability theorem. Finally, the numerical simulation experiments for an amplitude damping Markovian open quantum system are performed to prepare the desired quantum gate. The simulation results show that the preparation of Hadamard gate based on the proposed control laws can achieve the fidelity up to 0.9985 for the different coupling strengths.展开更多
This paper discusses the progress of computer integrated processing （CIPS） of coal-preparation and then preserits an intelligence controlled production-process, device-maintenance and production-management system of...This paper discusses the progress of computer integrated processing （CIPS） of coal-preparation and then preserits an intelligence controlled production-process, device-maintenance and production-management system of coal- preparation based on multi-agents （IICMMS-CP）. The construction of the IICMMS-CP, the distributed network control system based on live intelligence control stations and the strategy of implementing distributed intelligence control system are studied in order to overcome the disadvantages brought about by the wide use of the PLC system by coaipreparation plants. The software frame, based on a Multi-Agent Intelligence Control and Maintenance Management integrated system, is studied and the implemention methods of IICMMS-CP are discussed. The characteristics of distributed architecture, cooperation and parallel computing meet the needs of integrated control of coal-preparation plants with large-scale spatial production distribution, densely-related processes and complex systems. Its application further improves the reliability and precision of process control, accuracy of fault identification and intelligence of production adjustment, establishes a technical basis for system integration and flexible production. The main function of the system has been tested in a coal-preparation plant to good effect in stabilizing product quality, improving efficiency and reducing consumption.展开更多
Objective:This meta-analysis aimed to evaluate the effects of walking exercise on bowel preparation in patients undergoing colonoscopy.Methods:PubMed,Web of Science,EMBASE,Ovid,The Cochrane Library,Wanfang Data,China ...Objective:This meta-analysis aimed to evaluate the effects of walking exercise on bowel preparation in patients undergoing colonoscopy.Methods:PubMed,Web of Science,EMBASE,Ovid,The Cochrane Library,Wanfang Data,China National Knowledge Infrastructure,Chinese Science and Technology Periodical Database,and Chinese BioMedical Database were searched from their inception to January2019.Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) examining the effects of walking exercise in patients undergoing colonoscopy were considered for inclusion.After screening literature,extracting data and evaluating methodological quality,RevMan 5.3 software was used for meta-analysis.Results:Five studies (four RCTs and one CCTs) involved 984 participants were included.The results of meta-analysis demonstrated that the walking exercise group showed significantly higher improvements in the rate of adequate bowel preparation than the control group (risk ratio [RR]=1.28,95%confidence interval [CI][1.03-1.58],P <0.05).In addition,the walking exercise group had lower incidence of vomiting (RR=0.39,95%CI [0.23-0.68],P <0.01) and abdominal pain (RR=0.51,95%CI [0.29-0.90],P <0.05)with lower heterogeneity.Conclusions:This systematic review and meta-analysis provided specific evidence that walking exercise during bowel preparation can improve the rate of adequate bowel preparation and reduce the incidence of vomiting and abdominal pain in patients undergoing colonoscopy.Since the conclusion of this meta-analysis was drawn based on the limited number of high-quality RCTs,more rigorous RCTs sho uld be conducted in the future.展开更多
With the rapid development of asphalt pavement technology,it has attracted considerable attention to improving the durability of asphalt pavement.An effective action is to use modified asphalt with high performance an...With the rapid development of asphalt pavement technology,it has attracted considerable attention to improving the durability of asphalt pavement.An effective action is to use modified asphalt with high performance and durability.Polyurethane(PU)has been used in asphalt pavement engineering to enhance the durability and service life of asphalt pavement because of its excellent high-temperature performance,toughness,wear resistance,aging resistance and oil resistance.However,PU modified asphalt technology is still in the exploratory stage.The preparation,modification mechanism and working performances of PU modified asphalt need to be further clarified.Therefore,this paper summarized the research progress of PU modified asphalt and its mixture.The composition of PU modified asphalt was introduced.The addition methods of PU materials and preparation process parameters of the PU modified asphalt were determined.The modification mechanism of PU on asphalt was discussed.The effects of polyurethane on asphalt were analyzed and the road performances of its mixture were evaluated.Finally,the development tendency towards PU modified asphalt and its mixture were forecasted.展开更多
The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human body.Although adequate bowel preparation can i...The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human body.Although adequate bowel preparation can improve the results of colonoscopy,it may interfere with the gut microbiota.Bowel preparation for colonoscopy can lead to transient changes in the gut microbiota,potentially affecting an individual’s health,especially in vulnerable populations,such as patients with inflammatory bowel disease.However,measures such as oral pro-biotics may ameliorate these adverse effects.We focused on the bowel prepa-ration-induced changes in the gut microbiota and host health status,hypothesized the factors influencing these changes,and attempted to identify measures that may reduce dysbiosis,thereby providing more information for individualized bowel preparation for colonoscopy in the future.展开更多
OBJECTIVE:To systematically evaluate the effectiveness of Fuzheng Huayu preparation(扶正化瘀胶囊/片,FZHY)plus tenofovir disoproxil fumarate(TDF)on hepatitis B.METHODS:Numerous databases—PubM ed,Embase,Cochrane Librar...OBJECTIVE:To systematically evaluate the effectiveness of Fuzheng Huayu preparation(扶正化瘀胶囊/片,FZHY)plus tenofovir disoproxil fumarate(TDF)on hepatitis B.METHODS:Numerous databases—PubM ed,Embase,Cochrane Library,China National Knowledge Infrastructure Database,WanFang Database,China Science and Technology Journal Database,and China Biological Medicine Database—were searched to identify the randomized controlled trials published from the inception of the database to November 2021.Two researchers independently conducted literature screening,data extraction,and bias risk assessment.Rev Man 5.4 software was used for Meta-analysis.RESULTS:Eight studies involving 990 patients met the inclusion criteria in the current Meta-analysis.Levels of alanine transaminase,aspartate aminotransferase,total bilirubin,hyaluronic acid,typeⅢprocollagen,laminin,and type IV collagen after combination therapy were significantly lower than those after TDF therapy alone.However,albumin levels did not differ significantly between the two regimens.Subgroup analysis based on disease progression suggested that the combination therapy improved albumin levels in patients with chronic hepatitis B but not in patients with hepatitis B-related cirrhosis.Moreover,subgroup analysis based on treatment duration suggested that the albumin levels were increased and the typeⅢprocollagen levels were decreased with the>24-week combination therapy but not with the≤24-week combination therapy.CONCLUSIONS:A combination regimen of TDF and FZHY is more effective in treating hepatitis B than TDF alone.The combination therapy can effectively alleviate hepatic fibrosis and improve liver function.However,more standardized,highquality studies with larger sample sizes are warranted to validate the study results.展开更多
BACKGROUND Split-dose regimens(SpDs)of 4 L of polyethylene glycol(PEG)have been established as the“gold standard”for bowel preparation;however,its use is limited by the large volumes of fluids required and sleep dis...BACKGROUND Split-dose regimens(SpDs)of 4 L of polyethylene glycol(PEG)have been established as the“gold standard”for bowel preparation;however,its use is limited by the large volumes of fluids required and sleep disturbance associated with night doses.Meanwhile,the same-day single-dose regimens(SSDs)of PEG has been recommended as an alternative;however,its superiority compared to other regimens is a matter of debate.AIM To compare the efficacy and tolerability between SSDs and large-volume SpDs PEG for bowel preparation.METHODS We searched MEDLINE/PubMed,the Cochrane Library,RCA,EMBASE and Science Citation Index Expanded for randomized trials comparing(2 L/4 L)SSDs to large-volume(4 L/3 L)SpDs PEG-based regimens,regardless of adjuvant laxative use.The pooled analysis of relative risk ratio and mean difference was calculated for bowel cleanliness,sleep disturbance,willingness to repeat the procedure using the same preparation and adverse effects.A random effects model or fixed-effects model was chosen based on heterogeneity analysis among studies.RESULTS A total of 18 studies were included.There was no statistically significant difference of adequate bowel preparation(relative risk=0.97;95%CI:0.92-1.02)(14 trials),right colon Boston Bowel Preparation Scale(mean difference=0.00;95%CI:-0.04,0.03)(9 trials)and right colon Ottawa Bowel Preparation Scale(mean difference=0.04;95%CI:-0.27,0.34)(5 trials)between(2 L/4 L)SSDs and large-volume(4 L/3 L)SpDs,regardless of adjuvant laxative use.The pooled analysis favored the use of SSDs with less sleep disturbance(relative risk=0.52;95%CI:0.40,0.68)and lower incidence of abdominal pain(relative risk=0.75;95%CI:0.62,0.90).During subgroup analysis,patients that received low-volume(2 L)SSDs showed more willingness to repeat the procedure using the same preparation than SpDs(P<0.05).No significant difference in adverse effects,including nausea,vomiting and bloating,was found between the two arms(P>0.05).CONCLUSION Regardless of adjuvant laxative use,the(2 L/4 L)SSD PEG-based arm was considered equal or better than the large-volume(≥3 L)SpDs PEG regimen in terms of bowel cleanliness and tolerability.Patients that received low-volume(2 L)SSDs showed more willingness to repeat the procedure using the same preparation due to the low-volume fluid requirement and less sleep disturbance.展开更多
The preparation approach and calibration result of an improved type of ion selective electrode （ISE）, which is used to measure the total dissolved S^2-, are introduced in this paper. The improved Ag/Ag2S electrode u...The preparation approach and calibration result of an improved type of ion selective electrode （ISE）, which is used to measure the total dissolved S^2-, are introduced in this paper. The improved Ag/Ag2S electrode uses silver wire as the substrate, which is surrounded by electric polymer containing superfine silver powder. After the stabilization of the epoxy-resin, Ag2S layer was formed by chemical reaction with 0.2 mol/L （NH4）2S solution for 5 min. With Ag/AgC1 as reference electrode, the Ag/Ag2S electrode can be used to measure dissolved S^2-. The correlation between the measured potentials and the logarithm of dissolved S^2- is found to be linear, within range of the concentration of dissolved S^2- from 10^-2-10-7 mol/L. The slope of the regression line between measured potential and logarithm of dissolved S^2- is about -27.7, which agrees well with the theoretical Nernst value -29.6. Furthermore, the performance of the improved Ag/Ag2S electrode, such as the response time, sensitivity and stability, greatly outweighs the conventional Ag/Ag2S electrode.展开更多
CdS particles were generated in the mixed sodium 10- undecenoate--decyltrmethylammonium bromide vesicle dispersions.Depending on the condition and method of preparation. CdSsemi conductor absorption edges were found...CdS particles were generated in the mixed sodium 10- undecenoate--decyltrmethylammonium bromide vesicle dispersions.Depending on the condition and method of preparation. CdSsemi conductor absorption edges were found to range from 526 to 448 nm, corresponding to particle diameter between >5. 0 and 2. 7 nm.展开更多
A monitoring system using a piezoelectric sensor was developed for the quantitative analysis of the stirring process in which a mixture of a thickener with water was prepared. A thin piezoelectric sensor film was atta...A monitoring system using a piezoelectric sensor was developed for the quantitative analysis of the stirring process in which a mixture of a thickener with water was prepared. A thin piezoelectric sensor film was attached to the inside of a glass container in which the mixture was stirred and connected to a recorder. Seven healthy young participants were asked to conduct stirring for 90 s at three cycles per second (3 Hz). A triphasic wave with a large upward peak was recorded in each cycle of stirring. The average period across the seven participants was 0.337 s (n = 613 cycles), and statistical analysis revealed no significant difference between the average value and the expected value of 0.333 s. Video images captured during stirring were analyzed, and the analysis showed that the peak of the large upward wave appeared approximately 0.12 s (approximately 36% of the average period) after the time when the spoon head for stirring passed near the piezoelectric sensor. The monitoring system developed in this study allows the precise temporal analysis of stirring for the preparation of a mixture.展开更多
AIM: To study the root fracture resistance after root canal preparation with Ni-Ti rotary instruments and stainless hand instruments by means of meta-analysis.METHODS: Literature was researched in CNKI and CBMDisc, Pu...AIM: To study the root fracture resistance after root canal preparation with Ni-Ti rotary instruments and stainless hand instruments by means of meta-analysis.METHODS: Literature was researched in CNKI and CBMDisc, Pub Med, CALIS, Proquest, Web of Scienceand 11 kinds of Chinese or English dentistry journals. Retrieval time on Internet was in all years and hand retrieval time was from January 2013 to October 2013. The literatures were selected through reading abstracts and full texts by two reviewers independently and Revman 5 software was used to analysize the literature. RESULTS: Six articles met the inclusion criteria. According to Meta-analysis of tooth root bending properties, total standardized mean difference(SMD) was 0.63(95%CI:-0.24-1.50, P > 0.05). That indicated there was no statistically significant between the two groups. Subgroup analysis was carried out. SMD were 2.22(95%CI: 0.23-4.20, P < 0.05) and-0.61(95%CI:-1.05--0.17, P < 0.05) when the premolar teeth with a single canal or the mesiobuccal roots of molars were used as the materials for tests to compare the effects of different root canal preparation methods on root fracture resistance. That only indicated that there were statistically significant in two subgroups.CONCLUSION: In vitro experiments, the effects on the fracture resistance of root had no statistical difference with Ni-Ti rotary instruments and stainless steel hand instruments in root canal preparation.展开更多
By adjusting the order of adding oil phase and water phase,it was found that the emulsion prepared by d-phase method was more stable. Compared with the traditional anionic surfactant potassium cetaceanol phosphate,it ...By adjusting the order of adding oil phase and water phase,it was found that the emulsion prepared by d-phase method was more stable. Compared with the traditional anionic surfactant potassium cetaceanol phosphate,it was found that the sodium subtilis lipopeptide was more efficient.展开更多
Objective:This article systematically analyses the effects of adverse drug events/adverse drug reactions(ADEs/ADRs)of oral Indigo Naturalis(Qingdai)preparations in order to provide references for its rational clinical...Objective:This article systematically analyses the effects of adverse drug events/adverse drug reactions(ADEs/ADRs)of oral Indigo Naturalis(Qingdai)preparations in order to provide references for its rational clinical application.Methods:All clinical studies reporting ADE/ADR related to the oral administration of Qingdai preparations were searched through electronic databases,including PubMed,the Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),China Biology Medicine disc(CBM),VIP Information Chinese Journal Service Platform(VIP),and Wanfang database,from inception to September 27,2020.Information were extracted from these literatures,including primary disease,type of adverse reactions,dose,treatment,outcomes and so on.Incidence of ADE/ADR was estimated,as well as distribution of primary diseases and victim organs and systems were analyzed.Results:A total of 682 articles were included,with 651 clinical population studies and 31 case reports.Among them,604 detailed ADR/AE involving 33459 patients using oral Qingdai preparations,and a total of 5061 cases were found to present adverse events,including 2827 cases of digestive system(abdominal pain,diarrhea,etc.),469 cases of blood system damage(thrombocytopenia,leukopenia,anemia,etc.),313 cases of liver damage(abnormal liver function,liver toxicity,elevated liver enzymes,etc.),327 cases of nervous system reactions(headache,dizziness,poor sleep,etc.)and 1186 cases of other systems and organs.Severe adverse events(SAEs)mainly were liver damage,and could be relived after symptomatic treatment.Conclusion:From the systematic information retrieval and analysis,it is found that oral Qingdai preparations application may clinically cause ADEs/ADRs in terms of gastrointestinal tract and liver damage.Therefore,when using oral Qingdai preparations,liver and stomach protection should be done.At the same time,pay close attention to various biochemical indicators and the patient's drug response during the treatment process,and,if necessary,deal with it in time so as not to deteriorate the condition.Moreover,active surveillance system should be conducted to monitor ADE/ADR,so as to establish a clearer causal relationship between the drug and the adverse event.展开更多
Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,envir...Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and biomedicine.There-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be analyzed.Based on the presented studies of CF and its composite materials,the types and structures of the crystal are summarized.In addition,the current application technologies and theoretical mechanisms with various properties in different fields are elucidated.Moreover,the various preparation methods of CF and its composite materials are elaborated in detail.Most importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are identified.Furthermore,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.展开更多
With the acceleration of advanced industrialization and urbanization,the environment is deteriorating rapidly,and non-renewable energy resources are depleted.The gradual advent of potential clean energy storage techno...With the acceleration of advanced industrialization and urbanization,the environment is deteriorating rapidly,and non-renewable energy resources are depleted.The gradual advent of potential clean energy storage technologies is particularly urgent.Electrochemical energy storage technologies have been widely used in multiple fields,especially supercapacitors and rechargeable batteries,as vital elements of storing renewable energy.In recent years,two-dimensional material MXene has shown great potential in energy and multiple application fields thanks to its excellent electrical properties,large specific surface area,and tunability.Based on the layered materials of MXene,researchers have successfully achieved the dual functions of energy storage and conversion by adjusting the surface terminals at the Fermi level.It is worth noting that compared with other two-dimensional materials,MXene has more active sites on the basal plane,showing excellent catalytic performance.In contrast,other two-dimensional materials have catalytic activity only at the edge sites.This article comprehensively overviews the synthesis process,structural characteristics,modification methods for MXene-based polymer materials,and their applications in electrochemical energy storage.It also briefly discusses the potential of MXene-polymer materials in electromagnetic shielding technology and sensors and looks forward to future research directions.展开更多
OBJECTIVE The emergence of evolving variants of Coronavirus disease 2019(COVID-19)has fostered the need for change of newer and adaptive treatments for these infections.During the COVID-19 pandemic and persists,tradit...OBJECTIVE The emergence of evolving variants of Coronavirus disease 2019(COVID-19)has fostered the need for change of newer and adaptive treatments for these infections.During the COVID-19 pandemic and persists,traditional Chinese medicine(TCM)herbs exhibit significant bioactivity and therapeutic effect.This study is aimed to evaluate the efficacy of four TCM preparations on 28-day mortality risk of patients and changes of the laboratory indicators.METHODS The retrospective cohort study included patients with COVID-19 who were admitted to the Jiangsu Province Hospital of Chinese Medicine from December 15,2022 to January 15,2023,and those died within 48 hours of admission or cannot be tracked for outcomes were excluded.The primary outcome was survival status in 28 days(death or survival)starting from the day of admission.The second outcomes were laboratory indicators,including absolute lymphocyte count,lactate dehydrogenase,creatinine,and blood urea nitrogen.Binary logistic regressions were used to estimate the effect of TCM preparations on the primary and secondary outcomes in main analysis.Meanwhile,heterogeneity and robustness of results from main analysis were assessed by subgroup analyses and multiple sensitivity analyses.RESULTS 1816 eligible patients were included in analysis dataset,including 573 patients received standard care(control group)and 1243 patients received TCM preparations(hospital preparation group).The 28-day mortality rate of hospital preparation group was lower than that of control group(4.75%vs.14.83%),and the difference was statistically significant(χ^(2)=54.666,P<0.001).The risk of 28-day mortality was 0.535 times lower in the hospital preparation group as compared with the control group(OR=0.46,95%CI:0.305-0.708,P<0.001)showed by multivariable binary logistic regressions.Subgroup analyses showed that taking TCM preparations reduced the 28-day mortality risk.Sensitivity analyses demonstrated that the results of the main analysis for primary outcomes were robust.For secondary outcomes,the risk of abnormal absolute lymphocyte counts at discharge in the hospital preparation group decreased by 0.284 times(OR=0.703,95%CI:0.515-0.961,P=0.027).CONCLUSION Compared with standard of care,taking four hospital preparations including Kanggan Heji,Feining Heji,Qishen Gubiao Keli,and Qianghuo Qushi Qingwen Heji decreased risk of 28-day mortality among hospitalized COVID-19 patients.TCM therapy achieves adequate therapeutic effects in COVID-19.展开更多
BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylen...BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylene glycol formulation often fails to achieve the desired intestinal preparation effect.Linalotide has a unique mechanism of action,which can effectively enhance the secretion of small intestinal fluid and promote intestinal peristalsis.The combination of linaclotide and SF-PEG may provide a better solution for intestinal preparation and improve the quality of intestinal cleaning.Therefore,exploring the application value and clinical efficacy of linaclotide capsules combined with SF-PEG in intestinal preparation is of great clinical significance.AIM To explore the effects of the combination of linaclotide capsules and SF-PEG,including its efficacy in intestinal preparation and patient tolerance.METHODS To investigate the differences in the effectiveness of different bowel preparation plans in colonoscopy,this article conducted a comprehensive and detailed retrospective analysis of the medical records of patients who underwent colonoscopy from January 2023 to December 2023.In this study,116 patients were accurately divided into three groups based on the different intestinal preparation drugs used before colonoscopy.Among them,group A consisted of 29 patients who underwent intestinal preparation using 3 liters of SF-PEG combined with linaclotide;group B consists of 50 patients who underwent intestinal preparation using 3 liters of SF-PEG;group C consisted of 37 patients who underwent intestinal preparation using a combination of 2-liter SF-PEC and linaclotide.Subsequently,this article evaluated the quality of intestinal preparation in these three groups of patients,using the Boston bowel preparation scale(BBPS)as a quantitative indicator,while comparing multiple indicators such as intestinal preparation completion rate and detection of positive lesions,providing a strong basis for optimizing clinical intestinal preparation plans.RESULTS No statistically significant differences were found in BBPS scores(7.75±1.23,7.69±1.14,and 7.66±1.31;P=0.240),bowel preparation completion rates(96.55%,90.00%,and 97.30%;P=0.293),adenoma detection rates(20.69%,38.00%,and 32.43%;P=0.281),polyp detection rates(34.48%,50.00%,37.84%;P=0.326),insertion time(6.03±4.34,6.12±3.60,and 5.33±2.42;P=0.584),and patient satisfaction rates(89.66%,84.00%,and 97.30%;P=0.398)among the three groups.However,statistically significant differences were observed in withdrawal time(7.45±2.91,9.02±3.54,and 6.86±2.66;P=0.027)and adverse reaction rates(6.90%,20.00%,and 2.70%;P=0.029)among the three groups.Multiple comparisons showed that group C had significantly lower withdrawal time and adverse reaction rates than group B(P=0.013,P=0.016).CONCLUSION Linaclotide capsules show a trend in improving bowel preparation quality and reducing the dosage of SF-PEG.展开更多
DNA probes display advantages including flexible design,wide range of targets and high selectivity,but free DNA probes are confined to in vitro detection due to their poor cell penetration and low nuclease resistance....DNA probes display advantages including flexible design,wide range of targets and high selectivity,but free DNA probes are confined to in vitro detection due to their poor cell penetration and low nuclease resistance.Nanomaterials-loaded DNA probes can effectively solve above limitations and promote them in vivo applications.Gold nanoparticles-based probes have been intensely investigated in the past,and AuNP@DNA nanoflare as one of the most powerful tools for biomedical study has been developed.So far,towards Au NP@DNA nanoflare,significant advances in preparation(e.g.,salt-aging,low pH-assisted and freezing-directed linking)and application(e.g.,sensing and therapeutic nanoflares)have been achieved since first report.In addition,scientific challenges involved in AuNP@DNA nanoflares have been concerned and some endeavor has been made recently.Here,a historical review is provided for AuNP@DNA nanoflares:methodology in preparation and applications in bioanalysis and biomedicine are delineated,challenges and outlook are also discussed,which are expected to improve the further development of this fertile research area.展开更多
文摘The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_(2)CsSb photocathode has the advantages of high quantum efficiency, long lifetime and instantaneous response. This study introduces the design of a set of K_(2)CsSb photocathode preparation systems and detailed preparation process of K_(2)CsSb photocathodes, including sequential deposition process and co-deposition process, and finally develops a K_(2)CsSb photocathode. The influence of laser power on the quantum efficiency is also investigated.
基金Project supported by Laboratory of Environment Materials and Project in Jiangsu Province(017375003k11034)National Natural Science Foundation of China(20773106)
文摘Well-crystallized Nd2O3 nanorods were prepared in the aqueous solution containing neodymium nitrate, sodium hydroxide（dissolved in ethanol） and sodium dodecyl benzene sulfonate（SDBS）. One dimensional nanorods of neodymium hydroxide were synthesized first, which was then placed at different temperatures（600 and 800 ℃） in a calcar for 10 h to form Nd2O3 nanorods. The morphology and crystal structure of the products were investigated by X-ray diffraction, transmission electron microscopy, field emission transmission electron microscopy, Fourier transform infrared spectroscopy and fluorescence spectrometry. By using SDBS micelles as a template, this method manufactured uniform morphology of hexagonal one-dimensional neodymium oxide nanorods with a diameter ranging from 20 to 70 nm. The length of the nanorods increased with prolonged reaction time.
基金supported by National Natural Science Foundation of China(61573330)Chinese Academy of Sciences(CAS)the World Academy of Sciences(TWAS)
文摘In this paper, the control laws based on the Lyapunov stability theorem are designed for a two-level open quantum system to prepare the Hadamard gate, which is an important basic gate for the quantum computers. First, the density matrix interested in quantum system is transferred to vector formation.Then, in order to obtain a controller with higher accuracy and faster convergence rate, a Lyapunov function based on the matrix logarithm function is designed. After that, a procedure for the controller design is derived based on the Lyapunov stability theorem. Finally, the numerical simulation experiments for an amplitude damping Markovian open quantum system are performed to prepare the desired quantum gate. The simulation results show that the preparation of Hadamard gate based on the proposed control laws can achieve the fidelity up to 0.9985 for the different coupling strengths.
文摘This paper discusses the progress of computer integrated processing （CIPS） of coal-preparation and then preserits an intelligence controlled production-process, device-maintenance and production-management system of coal- preparation based on multi-agents （IICMMS-CP）. The construction of the IICMMS-CP, the distributed network control system based on live intelligence control stations and the strategy of implementing distributed intelligence control system are studied in order to overcome the disadvantages brought about by the wide use of the PLC system by coaipreparation plants. The software frame, based on a Multi-Agent Intelligence Control and Maintenance Management integrated system, is studied and the implemention methods of IICMMS-CP are discussed. The characteristics of distributed architecture, cooperation and parallel computing meet the needs of integrated control of coal-preparation plants with large-scale spatial production distribution, densely-related processes and complex systems. Its application further improves the reliability and precision of process control, accuracy of fault identification and intelligence of production adjustment, establishes a technical basis for system integration and flexible production. The main function of the system has been tested in a coal-preparation plant to good effect in stabilizing product quality, improving efficiency and reducing consumption.
文摘Objective:This meta-analysis aimed to evaluate the effects of walking exercise on bowel preparation in patients undergoing colonoscopy.Methods:PubMed,Web of Science,EMBASE,Ovid,The Cochrane Library,Wanfang Data,China National Knowledge Infrastructure,Chinese Science and Technology Periodical Database,and Chinese BioMedical Database were searched from their inception to January2019.Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) examining the effects of walking exercise in patients undergoing colonoscopy were considered for inclusion.After screening literature,extracting data and evaluating methodological quality,RevMan 5.3 software was used for meta-analysis.Results:Five studies (four RCTs and one CCTs) involved 984 participants were included.The results of meta-analysis demonstrated that the walking exercise group showed significantly higher improvements in the rate of adequate bowel preparation than the control group (risk ratio [RR]=1.28,95%confidence interval [CI][1.03-1.58],P <0.05).In addition,the walking exercise group had lower incidence of vomiting (RR=0.39,95%CI [0.23-0.68],P <0.01) and abdominal pain (RR=0.51,95%CI [0.29-0.90],P <0.05)with lower heterogeneity.Conclusions:This systematic review and meta-analysis provided specific evidence that walking exercise during bowel preparation can improve the rate of adequate bowel preparation and reduce the incidence of vomiting and abdominal pain in patients undergoing colonoscopy.Since the conclusion of this meta-analysis was drawn based on the limited number of high-quality RCTs,more rigorous RCTs sho uld be conducted in the future.
基金supported by Innovation Capability Support Program of Shaanxi(2022TD-07).
文摘With the rapid development of asphalt pavement technology,it has attracted considerable attention to improving the durability of asphalt pavement.An effective action is to use modified asphalt with high performance and durability.Polyurethane(PU)has been used in asphalt pavement engineering to enhance the durability and service life of asphalt pavement because of its excellent high-temperature performance,toughness,wear resistance,aging resistance and oil resistance.However,PU modified asphalt technology is still in the exploratory stage.The preparation,modification mechanism and working performances of PU modified asphalt need to be further clarified.Therefore,this paper summarized the research progress of PU modified asphalt and its mixture.The composition of PU modified asphalt was introduced.The addition methods of PU materials and preparation process parameters of the PU modified asphalt were determined.The modification mechanism of PU on asphalt was discussed.The effects of polyurethane on asphalt were analyzed and the road performances of its mixture were evaluated.Finally,the development tendency towards PU modified asphalt and its mixture were forecasted.
文摘The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human body.Although adequate bowel preparation can improve the results of colonoscopy,it may interfere with the gut microbiota.Bowel preparation for colonoscopy can lead to transient changes in the gut microbiota,potentially affecting an individual’s health,especially in vulnerable populations,such as patients with inflammatory bowel disease.However,measures such as oral pro-biotics may ameliorate these adverse effects.We focused on the bowel prepa-ration-induced changes in the gut microbiota and host health status,hypothesized the factors influencing these changes,and attempted to identify measures that may reduce dysbiosis,thereby providing more information for individualized bowel preparation for colonoscopy in the future.
基金Supported by the National Natural Science Foundation of China:the Molecular Mechanisms of Classical Prescription Sini Decoction plus Ginseng Soup to Rescue Acute Liver Failure:Regulating Hepatocyte Death Modes Mediated by PPARα/UCP2 Mitochondrial Uncoupling Pathway?(No.81973840)。
文摘OBJECTIVE:To systematically evaluate the effectiveness of Fuzheng Huayu preparation(扶正化瘀胶囊/片,FZHY)plus tenofovir disoproxil fumarate(TDF)on hepatitis B.METHODS:Numerous databases—PubM ed,Embase,Cochrane Library,China National Knowledge Infrastructure Database,WanFang Database,China Science and Technology Journal Database,and China Biological Medicine Database—were searched to identify the randomized controlled trials published from the inception of the database to November 2021.Two researchers independently conducted literature screening,data extraction,and bias risk assessment.Rev Man 5.4 software was used for Meta-analysis.RESULTS:Eight studies involving 990 patients met the inclusion criteria in the current Meta-analysis.Levels of alanine transaminase,aspartate aminotransferase,total bilirubin,hyaluronic acid,typeⅢprocollagen,laminin,and type IV collagen after combination therapy were significantly lower than those after TDF therapy alone.However,albumin levels did not differ significantly between the two regimens.Subgroup analysis based on disease progression suggested that the combination therapy improved albumin levels in patients with chronic hepatitis B but not in patients with hepatitis B-related cirrhosis.Moreover,subgroup analysis based on treatment duration suggested that the albumin levels were increased and the typeⅢprocollagen levels were decreased with the>24-week combination therapy but not with the≤24-week combination therapy.CONCLUSIONS:A combination regimen of TDF and FZHY is more effective in treating hepatitis B than TDF alone.The combination therapy can effectively alleviate hepatic fibrosis and improve liver function.However,more standardized,highquality studies with larger sample sizes are warranted to validate the study results.
基金Supported by Startup Fund for scientific research,Fujian Medical University,No. 2019QH1181
文摘BACKGROUND Split-dose regimens(SpDs)of 4 L of polyethylene glycol(PEG)have been established as the“gold standard”for bowel preparation;however,its use is limited by the large volumes of fluids required and sleep disturbance associated with night doses.Meanwhile,the same-day single-dose regimens(SSDs)of PEG has been recommended as an alternative;however,its superiority compared to other regimens is a matter of debate.AIM To compare the efficacy and tolerability between SSDs and large-volume SpDs PEG for bowel preparation.METHODS We searched MEDLINE/PubMed,the Cochrane Library,RCA,EMBASE and Science Citation Index Expanded for randomized trials comparing(2 L/4 L)SSDs to large-volume(4 L/3 L)SpDs PEG-based regimens,regardless of adjuvant laxative use.The pooled analysis of relative risk ratio and mean difference was calculated for bowel cleanliness,sleep disturbance,willingness to repeat the procedure using the same preparation and adverse effects.A random effects model or fixed-effects model was chosen based on heterogeneity analysis among studies.RESULTS A total of 18 studies were included.There was no statistically significant difference of adequate bowel preparation(relative risk=0.97;95%CI:0.92-1.02)(14 trials),right colon Boston Bowel Preparation Scale(mean difference=0.00;95%CI:-0.04,0.03)(9 trials)and right colon Ottawa Bowel Preparation Scale(mean difference=0.04;95%CI:-0.27,0.34)(5 trials)between(2 L/4 L)SSDs and large-volume(4 L/3 L)SpDs,regardless of adjuvant laxative use.The pooled analysis favored the use of SSDs with less sleep disturbance(relative risk=0.52;95%CI:0.40,0.68)and lower incidence of abdominal pain(relative risk=0.75;95%CI:0.62,0.90).During subgroup analysis,patients that received low-volume(2 L)SSDs showed more willingness to repeat the procedure using the same preparation than SpDs(P<0.05).No significant difference in adverse effects,including nausea,vomiting and bloating,was found between the two arms(P>0.05).CONCLUSION Regardless of adjuvant laxative use,the(2 L/4 L)SSD PEG-based arm was considered equal or better than the large-volume(≥3 L)SpDs PEG regimen in terms of bowel cleanliness and tolerability.Patients that received low-volume(2 L)SSDs showed more willingness to repeat the procedure using the same preparation due to the low-volume fluid requirement and less sleep disturbance.
基金the National Natural Science Foundation of China (No. 40637037)the Hi-Tech Research and Development Program (863) of China (No. 2006AA09Z216)
文摘The preparation approach and calibration result of an improved type of ion selective electrode （ISE）, which is used to measure the total dissolved S^2-, are introduced in this paper. The improved Ag/Ag2S electrode uses silver wire as the substrate, which is surrounded by electric polymer containing superfine silver powder. After the stabilization of the epoxy-resin, Ag2S layer was formed by chemical reaction with 0.2 mol/L （NH4）2S solution for 5 min. With Ag/AgC1 as reference electrode, the Ag/Ag2S electrode can be used to measure dissolved S^2-. The correlation between the measured potentials and the logarithm of dissolved S^2- is found to be linear, within range of the concentration of dissolved S^2- from 10^-2-10-7 mol/L. The slope of the regression line between measured potential and logarithm of dissolved S^2- is about -27.7, which agrees well with the theoretical Nernst value -29.6. Furthermore, the performance of the improved Ag/Ag2S electrode, such as the response time, sensitivity and stability, greatly outweighs the conventional Ag/Ag2S electrode.
文摘CdS particles were generated in the mixed sodium 10- undecenoate--decyltrmethylammonium bromide vesicle dispersions.Depending on the condition and method of preparation. CdSsemi conductor absorption edges were found to range from 526 to 448 nm, corresponding to particle diameter between >5. 0 and 2. 7 nm.
文摘A monitoring system using a piezoelectric sensor was developed for the quantitative analysis of the stirring process in which a mixture of a thickener with water was prepared. A thin piezoelectric sensor film was attached to the inside of a glass container in which the mixture was stirred and connected to a recorder. Seven healthy young participants were asked to conduct stirring for 90 s at three cycles per second (3 Hz). A triphasic wave with a large upward peak was recorded in each cycle of stirring. The average period across the seven participants was 0.337 s (n = 613 cycles), and statistical analysis revealed no significant difference between the average value and the expected value of 0.333 s. Video images captured during stirring were analyzed, and the analysis showed that the peak of the large upward wave appeared approximately 0.12 s (approximately 36% of the average period) after the time when the spoon head for stirring passed near the piezoelectric sensor. The monitoring system developed in this study allows the precise temporal analysis of stirring for the preparation of a mixture.
文摘AIM: To study the root fracture resistance after root canal preparation with Ni-Ti rotary instruments and stainless hand instruments by means of meta-analysis.METHODS: Literature was researched in CNKI and CBMDisc, Pub Med, CALIS, Proquest, Web of Scienceand 11 kinds of Chinese or English dentistry journals. Retrieval time on Internet was in all years and hand retrieval time was from January 2013 to October 2013. The literatures were selected through reading abstracts and full texts by two reviewers independently and Revman 5 software was used to analysize the literature. RESULTS: Six articles met the inclusion criteria. According to Meta-analysis of tooth root bending properties, total standardized mean difference(SMD) was 0.63(95%CI:-0.24-1.50, P > 0.05). That indicated there was no statistically significant between the two groups. Subgroup analysis was carried out. SMD were 2.22(95%CI: 0.23-4.20, P < 0.05) and-0.61(95%CI:-1.05--0.17, P < 0.05) when the premolar teeth with a single canal or the mesiobuccal roots of molars were used as the materials for tests to compare the effects of different root canal preparation methods on root fracture resistance. That only indicated that there were statistically significant in two subgroups.CONCLUSION: In vitro experiments, the effects on the fracture resistance of root had no statistical difference with Ni-Ti rotary instruments and stainless steel hand instruments in root canal preparation.
文摘By adjusting the order of adding oil phase and water phase,it was found that the emulsion prepared by d-phase method was more stable. Compared with the traditional anionic surfactant potassium cetaceanol phosphate,it was found that the sodium subtilis lipopeptide was more efficient.
基金This research was financially supported by The National Key R&D Program of China(Grant No.2019YFC1709802).
文摘Objective:This article systematically analyses the effects of adverse drug events/adverse drug reactions(ADEs/ADRs)of oral Indigo Naturalis(Qingdai)preparations in order to provide references for its rational clinical application.Methods:All clinical studies reporting ADE/ADR related to the oral administration of Qingdai preparations were searched through electronic databases,including PubMed,the Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),China Biology Medicine disc(CBM),VIP Information Chinese Journal Service Platform(VIP),and Wanfang database,from inception to September 27,2020.Information were extracted from these literatures,including primary disease,type of adverse reactions,dose,treatment,outcomes and so on.Incidence of ADE/ADR was estimated,as well as distribution of primary diseases and victim organs and systems were analyzed.Results:A total of 682 articles were included,with 651 clinical population studies and 31 case reports.Among them,604 detailed ADR/AE involving 33459 patients using oral Qingdai preparations,and a total of 5061 cases were found to present adverse events,including 2827 cases of digestive system(abdominal pain,diarrhea,etc.),469 cases of blood system damage(thrombocytopenia,leukopenia,anemia,etc.),313 cases of liver damage(abnormal liver function,liver toxicity,elevated liver enzymes,etc.),327 cases of nervous system reactions(headache,dizziness,poor sleep,etc.)and 1186 cases of other systems and organs.Severe adverse events(SAEs)mainly were liver damage,and could be relived after symptomatic treatment.Conclusion:From the systematic information retrieval and analysis,it is found that oral Qingdai preparations application may clinically cause ADEs/ADRs in terms of gastrointestinal tract and liver damage.Therefore,when using oral Qingdai preparations,liver and stomach protection should be done.At the same time,pay close attention to various biochemical indicators and the patient's drug response during the treatment process,and,if necessary,deal with it in time so as not to deteriorate the condition.Moreover,active surveillance system should be conducted to monitor ADE/ADR,so as to establish a clearer causal relationship between the drug and the adverse event.
基金supported by the National Natural Science Foundation of China(No.51574105)the Science and Technology Program of Hebei Province,China(No.23564101D)+2 种基金the Natural Science Foundation of Hebei Province,China(No.E2021209147)the Key Research Project of North China University of Science and Technology(No.ZD-ST-202308)the Postgraduate Innovation Funding Project of Hebei Province,China(No.CXZZBS2024135).
文摘Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and biomedicine.There-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be analyzed.Based on the presented studies of CF and its composite materials,the types and structures of the crystal are summarized.In addition,the current application technologies and theoretical mechanisms with various properties in different fields are elucidated.Moreover,the various preparation methods of CF and its composite materials are elaborated in detail.Most importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are identified.Furthermore,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.
基金supported by the Natural Science Basic Research Plan in the Shaanxi Province of China(No.2023-JC-ZD-25)Shaanxi Province(Qin ChuangYuan)“Scientist+Engineer”Team Building(No.2022KXJ-040)+1 种基金Shaanxi Provincial Department of Education Key Scientific Research Project(No.22JY024)Science and Technology Guidance Project Plan of China National Textile and Apparel Council(No.2022038,2023018).
文摘With the acceleration of advanced industrialization and urbanization,the environment is deteriorating rapidly,and non-renewable energy resources are depleted.The gradual advent of potential clean energy storage technologies is particularly urgent.Electrochemical energy storage technologies have been widely used in multiple fields,especially supercapacitors and rechargeable batteries,as vital elements of storing renewable energy.In recent years,two-dimensional material MXene has shown great potential in energy and multiple application fields thanks to its excellent electrical properties,large specific surface area,and tunability.Based on the layered materials of MXene,researchers have successfully achieved the dual functions of energy storage and conversion by adjusting the surface terminals at the Fermi level.It is worth noting that compared with other two-dimensional materials,MXene has more active sites on the basal plane,showing excellent catalytic performance.In contrast,other two-dimensional materials have catalytic activity only at the edge sites.This article comprehensively overviews the synthesis process,structural characteristics,modification methods for MXene-based polymer materials,and their applications in electrochemical energy storage.It also briefly discusses the potential of MXene-polymer materials in electromagnetic shielding technology and sensors and looks forward to future research directions.
文摘OBJECTIVE The emergence of evolving variants of Coronavirus disease 2019(COVID-19)has fostered the need for change of newer and adaptive treatments for these infections.During the COVID-19 pandemic and persists,traditional Chinese medicine(TCM)herbs exhibit significant bioactivity and therapeutic effect.This study is aimed to evaluate the efficacy of four TCM preparations on 28-day mortality risk of patients and changes of the laboratory indicators.METHODS The retrospective cohort study included patients with COVID-19 who were admitted to the Jiangsu Province Hospital of Chinese Medicine from December 15,2022 to January 15,2023,and those died within 48 hours of admission or cannot be tracked for outcomes were excluded.The primary outcome was survival status in 28 days(death or survival)starting from the day of admission.The second outcomes were laboratory indicators,including absolute lymphocyte count,lactate dehydrogenase,creatinine,and blood urea nitrogen.Binary logistic regressions were used to estimate the effect of TCM preparations on the primary and secondary outcomes in main analysis.Meanwhile,heterogeneity and robustness of results from main analysis were assessed by subgroup analyses and multiple sensitivity analyses.RESULTS 1816 eligible patients were included in analysis dataset,including 573 patients received standard care(control group)and 1243 patients received TCM preparations(hospital preparation group).The 28-day mortality rate of hospital preparation group was lower than that of control group(4.75%vs.14.83%),and the difference was statistically significant(χ^(2)=54.666,P<0.001).The risk of 28-day mortality was 0.535 times lower in the hospital preparation group as compared with the control group(OR=0.46,95%CI:0.305-0.708,P<0.001)showed by multivariable binary logistic regressions.Subgroup analyses showed that taking TCM preparations reduced the 28-day mortality risk.Sensitivity analyses demonstrated that the results of the main analysis for primary outcomes were robust.For secondary outcomes,the risk of abnormal absolute lymphocyte counts at discharge in the hospital preparation group decreased by 0.284 times(OR=0.703,95%CI:0.515-0.961,P=0.027).CONCLUSION Compared with standard of care,taking four hospital preparations including Kanggan Heji,Feining Heji,Qishen Gubiao Keli,and Qianghuo Qushi Qingwen Heji decreased risk of 28-day mortality among hospitalized COVID-19 patients.TCM therapy achieves adequate therapeutic effects in COVID-19.
基金Supported by the Science and Technology Program of Rui’an,No.MS2023030.
文摘BACKGROUND In the field of clinical intestinal preparation,compound polyethylene glycol electrolyte solution(SF-PEG)is a commonly used intestinal cleaner.However,practice has shown that using only a single polyethylene glycol formulation often fails to achieve the desired intestinal preparation effect.Linalotide has a unique mechanism of action,which can effectively enhance the secretion of small intestinal fluid and promote intestinal peristalsis.The combination of linaclotide and SF-PEG may provide a better solution for intestinal preparation and improve the quality of intestinal cleaning.Therefore,exploring the application value and clinical efficacy of linaclotide capsules combined with SF-PEG in intestinal preparation is of great clinical significance.AIM To explore the effects of the combination of linaclotide capsules and SF-PEG,including its efficacy in intestinal preparation and patient tolerance.METHODS To investigate the differences in the effectiveness of different bowel preparation plans in colonoscopy,this article conducted a comprehensive and detailed retrospective analysis of the medical records of patients who underwent colonoscopy from January 2023 to December 2023.In this study,116 patients were accurately divided into three groups based on the different intestinal preparation drugs used before colonoscopy.Among them,group A consisted of 29 patients who underwent intestinal preparation using 3 liters of SF-PEG combined with linaclotide;group B consists of 50 patients who underwent intestinal preparation using 3 liters of SF-PEG;group C consisted of 37 patients who underwent intestinal preparation using a combination of 2-liter SF-PEC and linaclotide.Subsequently,this article evaluated the quality of intestinal preparation in these three groups of patients,using the Boston bowel preparation scale(BBPS)as a quantitative indicator,while comparing multiple indicators such as intestinal preparation completion rate and detection of positive lesions,providing a strong basis for optimizing clinical intestinal preparation plans.RESULTS No statistically significant differences were found in BBPS scores(7.75±1.23,7.69±1.14,and 7.66±1.31;P=0.240),bowel preparation completion rates(96.55%,90.00%,and 97.30%;P=0.293),adenoma detection rates(20.69%,38.00%,and 32.43%;P=0.281),polyp detection rates(34.48%,50.00%,37.84%;P=0.326),insertion time(6.03±4.34,6.12±3.60,and 5.33±2.42;P=0.584),and patient satisfaction rates(89.66%,84.00%,and 97.30%;P=0.398)among the three groups.However,statistically significant differences were observed in withdrawal time(7.45±2.91,9.02±3.54,and 6.86±2.66;P=0.027)and adverse reaction rates(6.90%,20.00%,and 2.70%;P=0.029)among the three groups.Multiple comparisons showed that group C had significantly lower withdrawal time and adverse reaction rates than group B(P=0.013,P=0.016).CONCLUSION Linaclotide capsules show a trend in improving bowel preparation quality and reducing the dosage of SF-PEG.
基金supported in part by the financial support through the National Natural Science Foundation of China(Nos.22074008,22222402,22207098)Natural Science Foundation of Hunan Province(No.2024J13001)+1 种基金the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Huan Province(No.2023ct01)The Special Fund for Zaozhuang Talent Agglomeration Project。
文摘DNA probes display advantages including flexible design,wide range of targets and high selectivity,but free DNA probes are confined to in vitro detection due to their poor cell penetration and low nuclease resistance.Nanomaterials-loaded DNA probes can effectively solve above limitations and promote them in vivo applications.Gold nanoparticles-based probes have been intensely investigated in the past,and AuNP@DNA nanoflare as one of the most powerful tools for biomedical study has been developed.So far,towards Au NP@DNA nanoflare,significant advances in preparation(e.g.,salt-aging,low pH-assisted and freezing-directed linking)and application(e.g.,sensing and therapeutic nanoflares)have been achieved since first report.In addition,scientific challenges involved in AuNP@DNA nanoflares have been concerned and some endeavor has been made recently.Here,a historical review is provided for AuNP@DNA nanoflares:methodology in preparation and applications in bioanalysis and biomedicine are delineated,challenges and outlook are also discussed,which are expected to improve the further development of this fertile research area.
