Dear Editor,Plant antimicrobial peptides(PAMPs)are small bioactive molecules with broad-spectrum antimicrobial activity,low toxicity,and roles in promoting plant growth,making them promising candidates for application...Dear Editor,Plant antimicrobial peptides(PAMPs)are small bioactive molecules with broad-spectrum antimicrobial activity,low toxicity,and roles in promoting plant growth,making them promising candidates for applications in sustainable agriculture and translational medicine(Nagella et al.,2025).However,PAMP discovery is constrained by the requirement for labor-intensive wet-lab validation and by the limitations of computational AMP predictors,which often rely on handcrafted features,shallow embeddings,fixed-length sequences,or intensive computation,thereby reducing their accuracy and generalizability in realworld settings(Qin et al.,2025).展开更多
基金supported by the Biotechnology AI Innovation Practice II program(project no.K1401010.01)at the University of Electronic Science and Technology of China(UESTC)the National Natural Science Foundation of China(62172078,62402089,and 62373079)the China Postdoctoral Science Foundation(2023TQ0047 and GZC20230380).
文摘Dear Editor,Plant antimicrobial peptides(PAMPs)are small bioactive molecules with broad-spectrum antimicrobial activity,low toxicity,and roles in promoting plant growth,making them promising candidates for applications in sustainable agriculture and translational medicine(Nagella et al.,2025).However,PAMP discovery is constrained by the requirement for labor-intensive wet-lab validation and by the limitations of computational AMP predictors,which often rely on handcrafted features,shallow embeddings,fixed-length sequences,or intensive computation,thereby reducing their accuracy and generalizability in realworld settings(Qin et al.,2025).
