Calculating the inter-layer ion diffusion barrier, a crucial metric for evaluating the rate performance of 2D electrode materials, is time-consuming using the transition state search approach. A novel electrostatic po...Calculating the inter-layer ion diffusion barrier, a crucial metric for evaluating the rate performance of 2D electrode materials, is time-consuming using the transition state search approach. A novel electrostatic potential distribution image (EPDI) transfer learning method has been proposed to efficiently and accurately predict the lithium diffusion barriers on metal element-doped transition metal dichalcogenide (TMD) surfaces. Through the analysis of the mean electrostatic potential (MEP) around binding sites, a positive correlation between binding energy and MEP in VIB-TMDs was identified. Subsequently, transfer learning techniques were used to develop a DenseNet121-TL model for establishing a more accurate mapping between the binding energy and electrostatic potential distribution. Trained on training sets containing 33% and 50% transition state search calculation results, which save 66% and 50% of the calculation time, respectively, the model achieves accurate predictions of the saddle point binding energy with mean absolute errors (MAEs) of 0.0444 and 0.0287 eV on the testing set. Based on the prediction of saddle point binding energies, we obtained a diffusion minimum energy profile with an MAE of 0.0235 eV. Furthermore, by analyzing the diffusion data, we observed that the diffusion barrier was lowered by 10% on V-doped TiS2 compared to the stoichiometric surface. Our findings are expected to provide new insights for the high-throughput calculation of ion diffusion on 2D materials.展开更多
Machine learning(ML)has emerged as a powerful tool for predicting polymer properties,including glass transition temperature(Tg),which is a critical factor influencing polymer applications.In this study,a dataset of po...Machine learning(ML)has emerged as a powerful tool for predicting polymer properties,including glass transition temperature(Tg),which is a critical factor influencing polymer applications.In this study,a dataset of polymer structures and their Tg values were created and represented as adjacency matrices based on molecular graph theory.Four key structural descriptors,flexibility,side chain occupancy length,polarity,and hydrogen bonding capacity,were extracted and used as inputs for ML models:Extra Trees(ET),Random Forest(RF),Gaussian Process Regression(GPR),and Gradient Boosting(GB).Among these,ET and GPR achieved the highest predictive performance,with R2 values of 0.97,and mean absolute errors(MAE)of approximately 7–7.5 K.The use of these extracted features significantly improved the prediction accuracy compared to previous studies.Feature importance analysis revealed that flexibility had the strongest influence on Tg,followed by side-chain occupancy length,hydrogen bonding,and polarity.This work demonstrates the potential of data-driven approaches in polymer science,providing a fast and reliable method for Tg prediction that does not require experimental inputs.展开更多
The reactor pressure vessel(RPV)is susceptible to brittle fracture due to the influence of ion irradiation and high temperature,which presents a significant risk to the safe operation of nuclear reactors.It has been d...The reactor pressure vessel(RPV)is susceptible to brittle fracture due to the influence of ion irradiation and high temperature,which presents a significant risk to the safe operation of nuclear reactors.It has been demonstrated that pulsed electric current can effectively address the issue of embrittlement in RPV steel.However,the relationship between pulse parameters(duty ratio,frequency,current,and time)and the effectiveness of pulse current processing has not been systematically studied.The application of machine learning methods enables autonomous exploration and learning of the relationship between data.Consequently,this study proposes a machine learning method based on the random forest model to establish the relationship between the parameters of electrical pulses and the repair effect of RPV steel.A generative adversarial network is employed to enhance data diversity and scalability,while a particle swarm optimization algorithm is utilized to optimize the initialization weights and biases of the random forest model,aiming to improve the model’s fitting ability and training performance.The results indicate that the coefficient of determination R-square(R^(2)),root mean squared error and mean absolute error values are 0.934,0.045,and 0.036,respectively,suggesting that the model has the potential to predict the performance recovery of RPV steel after pulsed electric field treatment.The prediction of the impact of pulse current parameters on the repair effect will help to enhance and optimize the repair process,thereby providing a scientific basis for pulse current repair processing.展开更多
Recent advancements have led to the synthesis of various new metal-containing explosives,particularly energetic metal-organic frameworks(EMOFs),which feature high-energy ligands within well-ordered crystalline structu...Recent advancements have led to the synthesis of various new metal-containing explosives,particularly energetic metal-organic frameworks(EMOFs),which feature high-energy ligands within well-ordered crystalline structures.These explosives exhibit significant advantages over traditional compounds,including higher density,greater heats of detonation,improved mechanical hardness,and excellent thermal stability.To effectively evaluate their detonation performance,it is crucial to have a reliable method for predicting detonation heat,velocity,and pressure.This study leverages experimental data and outputs from the leading commercial computer code to identify suitable decomposition pathways for different metal oxides,facilitating straightforward calculations for the detonation performance of alkali metal salts,and metal coordination compounds,along with EMOFs.The new model enhances predictive reliability for detonation velocities,aligning more closely with experimental results,as evi-denced by a root mean square error(RMSE)of 0.68 km/s compared to 1.12 km/s for existing methods.Furthermore,it accommodates a broader range of compounds,including those containing Sr,Cd,and Ag,and provides predictions for EMOFs that are more consistent with computer code outputs than previous predictive models.展开更多
China Oil&Gas,as a prominent academic journal in the energy industry,has been dedicated to advancing academic research and industrial development in the oil and gas energy field.As one of the authoritative media o...China Oil&Gas,as a prominent academic journal in the energy industry,has been dedicated to advancing academic research and industrial development in the oil and gas energy field.As one of the authoritative media outlets in the international energy sector,the magazine has long focused on the evolution of the global energy landscape and has organized and participated in several influential academic activities and research projects.展开更多
Background:The aim was to explore the effect of macrophage polarization and macrophage-to-myofibroblast transition(MMT)in silicosis.Methods:Male Wistar rats were divided into a control group and a silicosis group deve...Background:The aim was to explore the effect of macrophage polarization and macrophage-to-myofibroblast transition(MMT)in silicosis.Methods:Male Wistar rats were divided into a control group and a silicosis group developed using a HOPE MED 8050 dynamic automatic dusting system.Murine mac-rophage MH-S cells were randomly divided into a control group and an SiO_(2) group.The pathological changes in lung tissue were observed using hematoxylin and eosin(HE)and Van Gieson(VG)staining.The distribution and location of macrophage marker(F4/80),M1 macrophage marker(iNOS),M2 macrophage marker(CD206),and myofibroblast marker(α-smooth muscle actin[α-SMA])were detected using immu-nohistochemical and immunofluorescent staining.The expression changes in iNOS,Arg,α-SMA,vimentin,and type I collagen(Col I)were measured using Western blot.Results:The results of HE and VG staining showed obvious silicon nodule formation and the distribution of thick collagen fibers in the lung tissue of the silicosis group.Macrophage marker F4/80 increased gradually from 8 to 32 weeks after exposure to silica.Immunohistochemical and immunofluorescent staining results revealed that there were more iNOS-positive cells and some CD206-positive cells in the lung tissue of the silicosis group at 8 weeks.More CD206-positive cells were found in the silicon nodules of the lung tissues in the silicosis group at 32 weeks.Western blot analysis showed that the expressions of Inducible nitric oxide synthase and Arg protein in the lung tissues of the silicosis group were upregulated compared with those of the con-trol group.The results of immunofluorescence staining showed the co-expression of F4/80,α-SMA,and Col I,and CD206 andα-SMA were co-expressed in the lung tissue of the silicosis group.The extracted rat alveolar lavage fluid revealed F4/80+α-SMA+,CD206+α-SMA+,and F4/80+α-SMA+Col I+cells using immunofluorescence staining.Similar results were also found in MH-S cells induced by SiO_(2).Conclusions:The development of silicosis is accompanied by macrophage polarization and MMT.展开更多
In the present study,we aimed to investigate whether anlotinib reverses osimertinib resistance by inhibiting the formation of epithelial-mesenchymal transition(EMT)and angiogenesis.In a clinical case,anlotinib reverse...In the present study,we aimed to investigate whether anlotinib reverses osimertinib resistance by inhibiting the formation of epithelial-mesenchymal transition(EMT)and angiogenesis.In a clinical case,anlotinib reversed osimertinib resistance in non-small cell lung cancer(NSCLC).Therefore,we performed immunohistochemical analyses on tumor tissues from three NSCLC patients with osimertinib resistance to analyze alterations in the expression levels of EMT markers and vascular endothelial growth factor A(VEGFA)before and after the development of osimertinib resistance.The results revealed the downregulation of E-cadherin,coupled with the upregulation of vimentin and VEGFA in tumor tissues of patients exhibiting osimertinib resistance,compared with those in tissues from patients before receiving osimertinib.Subsequently,we established osimertinib-resistant(Osi-R)cell lines and found that the Osi-R cells acquired EMT features.Next,we analyzed the synergistic effects of the combination therapy to verify whether anlotinib could reverse osimertinib resistance by inhibiting EMT.The expression levels of VEGFA and tube formation were analyzed in the combination group in vitro.Finally,we determined the reversal of osimertinib resistance by the combination of osimertinib and anlotinib in vivo using 20 nude mice.The combined treatment of osimertinib and anlotinib effectively prevented the metastasis of Osi-R cells,inhibited tumor growth,exerted antitumor activity,and ultimately reversed osimertinib resistance in mice.The co-administration of osimertinib and anlotinib demonstrated synergistic efficacy in inhibiting EMT and angiogenesis in three NSCLC patients,ultimately reversing osimertinib resistance.展开更多
This study constructs a function-private inner-product predicate encryption(FP-IPPE)and achieves standard enhanced function privacy.The enhanced function privacy guarantees that a predicate secret key skf reveals noth...This study constructs a function-private inner-product predicate encryption(FP-IPPE)and achieves standard enhanced function privacy.The enhanced function privacy guarantees that a predicate secret key skf reveals nothing about the predicate f,as long as f is drawn from an evasive distribution with sufficient entropy.The proposed scheme extends the group-based public-key function-private predicate encryption(FP-PE)for“small superset predicates”proposed by Bartusek et al.(Asiacrypt 19),to the setting of inner-product predicates.This is the first construction of public-key FP-PE with enhanced function privacy security beyond the equality predicates,which is previously proposed by Boneh et al.(CRYPTO 13).The proposed construction relies on bilinear groups,and the security is proved in the generic bilinear group model.展开更多
A novel substrate integrated microstrip to ultra-thin cavity filter transition operating in the W-band is proposed in this letter.The structure is a new method of connecting microstrip circuits and waveguide filters,a...A novel substrate integrated microstrip to ultra-thin cavity filter transition operating in the W-band is proposed in this letter.The structure is a new method of connecting microstrip circuits and waveguide filters,and this new structure enables a planar integrated transition from microstrip lines to ultra-thin cavity filters,thereby reducing the size of the transition structure and achieving miniaturization.The structure includes a conventional tapered microstrip transition structure,which guides the electromagnetic field from the microstrip line to the reduced-height dielectric-filled waveguide,and an air-filled matching cavity which is placed between the dielectric-filled waveguide and the ultra-thin cavity filter.The heights of the microstrip line,the dielectric-filled waveguide and the ultra-thin cavity filter are the same,enabling seamless integration within a planar radio-frequency(RF)circuit.To facilitate testing,mature finline transition structures are integrated at both ends of the microstrip line during fabrications.The simulation results of the fabricated microstrip to ultra-thin cavity filter transition with the finline transition structure,with a passband of 91.5-96.5 GHz,has an insertion loss of less than 1.9 dB and a return loss lower than-20 dB.And the whole structure has also been measured which achieves an insertion loss less than 2.6 dB and a return loss lower than-15 dB within the filter's passband,including the additional insertion loss introduced by the finline transitions.Finally,a W-band compact up-conversion module is designed,and the test results show that after using the proposed structure,the module achieves 95 dBc suppression of the 84 GHz local oscillator.It is also demonstrated that the structure proposed in this letter achieves miniaturization of the system integration without compromising the filter performance.展开更多
Introduction and Background: Registered nurses’ transit to the clinical placement areas after completing a three-year Bachelor of Nursing training. They should be supported by nurse leaders and nurse educators;to gai...Introduction and Background: Registered nurses’ transit to the clinical placement areas after completing a three-year Bachelor of Nursing training. They should be supported by nurse leaders and nurse educators;to gain confidence and the ability to perform critical care nursing, deal with high patient numbers, the ability to work independently and manage relationships with providers, families and the interprofessional team. Methods: A qualitative research design was employed to explore two important aspects of nursing professionalism. Firstly, the sentiments of senior registered nurses about professional mentorship of newly graduated nurses NGNs. Secondly the strategies employed by senior nurses to assist the transition of NGNs to professional nursing. Two nurse unit managers (NUM) participated as key informants. Results: Two themes will be discussed from the pilot study: Responsibilities and challenges faced by senior nurses while they supervise (NGNs) in their wards. Senior nurses’ workload and responsibilities fully occupy them during the days’ work, leaving very little time to spend supervising the NGNs. The challenges faced by senior nurses are those of restricted time, no proper resources, and mentoring manuals to guide the senior nurses. Discussion: The results of the pilot study present the challenges of senior nurses in supervising and training NGNs during transition, as they must complete the administrative tasks, finalizing rosters, and have direct patient contact. They usually face challenges while supervising the NGNs, sometimes leaving them to work on their own where the NGN is prone to make mistakes during patient care. Conclusion: Support and supervision are key to a successful transition, but senior nurses face difficulties, and challenges in many forms, there are no mentors available for the NGNs in any ward at the CWM Hospital while they train and supervise them during transitions. SNs take up a lot of responsibilities and provide support and supervision to NGNs. Some NGNs have undesirable attitudes that hinder the learning and teaching process. They also acknowledge that NGNs also need to play their role in learning to adapt to the new clinical environment with various challenges they face themselves.展开更多
Layered transition metal oxides have emerged as promising cathode materials for sodium ion batteries.However,irreversible phase transitions cause structural distortion and cation rearrangement,leading to sluggish Na+d...Layered transition metal oxides have emerged as promising cathode materials for sodium ion batteries.However,irreversible phase transitions cause structural distortion and cation rearrangement,leading to sluggish Na+dynamics and rapid capacity decay.In this study,we propose a medium-entropy cathode by simultaneously introducing Fe,Mg,and Li dopants into a typical P2-type Na_(0.75)Ni_(0.25)Mn_(0.75)O_(2)cathode.The modified Na_(0.75)Ni_(0.2125)Mn_(0.6375)Fe_(0.05)Mg_(0.05)Li_(0.05)O_(2)cathode predominantly exhibits a main P2 phase(93.5%)with a minor O3 phase(6.5%).Through spectroscopy techniques and electrochemical investigations,we elucidate the redox mechanisms of Ni^(2+/3+/4+),Mn^(3+/4+),Fe^(3+/4+),and O_(2)-/O_(2)^(n-)during charging/discharging.The medium-entropy doping mitigates the detrimental P2-O_(2)phase transition at high-voltage,replacing it with a moderate and reversible structural evolution(P2-OP4),thereby enhancing structural stability.Consequently,the modified cathode exhibits a remarkable rate capacity of 108.4 mAh·g^(-1)at 10C,with a capacity retention of 99.0%after 200 cycles at 1C,82.5%after 500 cycles at 5C,and 76.7%after 600 cycles at 10C.Furthermore,it also demonstrates superior electrochemical performance at high cutoff voltage of 4.5 V and extreme temperature(55 and 0℃).This work offers solutions to critical challenges in sodium ion batteries cathode materials.展开更多
BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G proteins.The speci-fic effect of RGS,particularly RGS4,on the progr...BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G proteins.The speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet clear.AIM To explore the role and underlying mechanisms of action of RGS4 in GC develop-ment.METHODS The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with GC.Function assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in vitro.RESULTS RGS4 was highly expressed in GC tissues compared with matched adjacent normal tissues.Elevated RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with GC.Cell experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and invasion.Similarly,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor growth.Moreover,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated E-cadherin.CONCLUSION High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic marker.RGS4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.展开更多
Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, ...Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, sub-Saharan Africa is in the first phase of development corresponding to the “age of plague and famine”. Given the health statistics currently available, more and more low- and middle-income countries, including those in sub-Saharan Africa, are experiencing an increase in mortality and the economic impact associated with non-communicable diseases. Côte d’Ivoire is one of the countries in sub-Saharan Africa where non-communicable diseases are currently on the rise. Despite the significant changes observed over the last decades, few studies have been carried out on the epidemiological transition in Côte d’Ivoire. It therefore seemed necessary to examine the changes in patterns of disease occurrence and causes of death in Côte d’Ivoire. Objectives: This work aimed to determine the reality of the epidemiological transition in Côte d’Ivoire and characterize its facies from 1990 to 2020. Methods: A literature review was carried out using PubMed, Medline, Google Scholar, Google, institutional websites (WHO, World Bank), university library websites and institutional reports from Côte d’Ivoire. The indicators sought were mortality, morbidity, life expectancy and fertility. Results: Mortality fell overall from 13.88‰ to 9.70‰, with variations linked to cyclical situations. Life expectancy rose by 52.6 to 59.03 years, although it is still below 60. Fertility has fallen from 6.3 to 4.5 children. There is a general downward trend in morbidity due to communicable diseases between 2009 and 2019, followed by an increase in non-communicable diseases. Conclusion: Côte d’Ivoire is undergoing an original and complex epidemiological transition that needs to be taken into account in health policies and strategies.展开更多
A bearing fault diagnosis method based on the Markov transitionfield(MTF)and SEnet(SE)-IShufflenetV2 model is proposed in this paper due to the problems of complex working conditions,low fault diagnosis accuracy,and poo...A bearing fault diagnosis method based on the Markov transitionfield(MTF)and SEnet(SE)-IShufflenetV2 model is proposed in this paper due to the problems of complex working conditions,low fault diagnosis accuracy,and poor generalization of rolling bearing.Firstly,MTF is used to encode one-dimensional time series vibration sig-nals and convert them into time-dependent and unique two-dimensional feature images.Then,the generated two-dimensional dataset is fed into the SE-IShufflenetV2 model for training to achieve fault feature extraction and classification.This paper selects the bearing fault datasets from Case Western Reserve University and Paderborn University to experimentally verify the effectiveness and superiority of the proposed method.The generalization performance of the proposed method is tested under the variable load condition and different signal-to-noise ratios(SNRs).The experimental results show that the average accuracy of the proposed method under different working conditions is 99.2%without adding noise.The accuracy under different working conditions from 0 to 1 HP is 100%.When the SNR is 0 dB,the average accuracy of the proposed method can still reach 98.7%under varying working conditions.Therefore,the bearing fault diagnosis method proposed in this paper is characterized by high accuracy,strong anti-noise ability,and generalization.Moreover,the proposed method can also overcome the influence of variable working conditions on diagnosis accuracy,providing method support for the accurate diagnosis of bearing faults under strong noise and variable working conditions.展开更多
Epithelial-mesenchymal transition(EMT)plays an irreplaceable role in the development of silicosis.However,molecular mechanisms of EMT induced by silica exposure still remain to be addressed.Herein,metabolic profiles o...Epithelial-mesenchymal transition(EMT)plays an irreplaceable role in the development of silicosis.However,molecular mechanisms of EMT induced by silica exposure still remain to be addressed.Herein,metabolic profiles of human alveolar type II epithelial cells(A549 cells)exposed directly to silica were characterized using non-targeted metabolomic approaches.A total of 84 differential metabolites(DMs)were identified in silica-treated A549 cells undergoing EMT,which were mainly enriched in metabolisms of amino acids(e.g.,glutamate,alanine,aspartate),purine metabolism,glycolysis,etc.The number of DMs identified in the A549 cells obviously increased with the elevated exposure concentration of silica.Remarkably,glutamine catabolism was significantly promoted in the silica-treated A549 cells,and the levels of related metabolites(e.g.,succinate)and enzymes(e.g.,α-ketoglutarate(α-KG)dehydrogenase)were substantially up-regulated,with a preference toα-KG pathway.Supplementation of glutamine into the cell culture could substantially enhance the expression levels of both EMT-related markers and Snail(zinc finger transcription factor).Our results suggest that the EMT of human alveolar epithelial cells directly induced by silica can be essential to the development of silicosis.展开更多
The pressure-actuated metal seal with soft metal coating has been widely used in complex working conditions such as high temperature,low temperature and high pressure.The investigation of the characteristics and bindi...The pressure-actuated metal seal with soft metal coating has been widely used in complex working conditions such as high temperature,low temperature and high pressure.The investigation of the characteristics and binding strength of the transition layer between the soft metal coating and the superalloy substrate is important to improve the sealing performance and to model and simplify the working through-process of metal sealing.The distribution characteristics of elements at soft metal-substrate interface and the binding strength between coating and substrate under different thicknesses and material combinations of coating layer were studied by experimental methods.The results indicate that the thickness of soft metal coating has little influence on the interface morphology of GH4169-Cu,GH4169-Ag and Cu-Ag,but has an influence on the thickness of transition layer between different metals,while this influence is weakened with increasing the coating thickness,and the thickness of transition layer is about 2μm when the coating thickness is more than 30μm.The cross-cut test shows that the Cu,Ag and Cu-Ag coatings are all well combined with nickel-based superalloy GH4169 substrate.The materials of soft metal,i.e.the coating materials,have significant influence on the characteristic of transition layer and the surface characteristics of coating after cross-cut test.展开更多
Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing up.These normal experiences are potentially magnified for teenagers living with chronic ...Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing up.These normal experiences are potentially magnified for teenagers living with chronic illness or disability and their families.Advances in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing morbidity.For those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of life.At the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general hospitals.While there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive care.Many patients may encounter considerable challenges during this period.Difficulties may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric conditions.In addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health issues.These challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.展开更多
Code obfuscation is a crucial technique for protecting software against reverse engineering and security attacks.Among various obfuscation methods,opaque predicates,which are recognized as flexible and promising,are w...Code obfuscation is a crucial technique for protecting software against reverse engineering and security attacks.Among various obfuscation methods,opaque predicates,which are recognized as flexible and promising,are widely used to increase control-flow complexity.However,traditional opaque predicates are increasingly vulnerable to Dynamic Symbolic Execution(DSE)attacks,which can efficiently identify and eliminate them.To address this issue,this paper proposes a novel approach for anti-DSE opaque predicates that effectively resists symbolic execution-based deobfuscation.Our method introduces two key techniques:single-way function opaque predicates,which leverage hash functions and logarithmic transformations to prevent constraint solvers from generating feasible inputs,and path-explosion opaque predicates,which generate an excessive number of execution paths,overwhelming symbolic execution engines.To evaluate the effectiveness of our approach,we implemented a prototype obfuscation tool and tested it against prominent symbolic execution engines.Experimental results demonstrate that our approach signifi-cantly increases resilience against symbolic execution attacks while maintaining acceptable performance overhead.This paper provides a robust and scalable obfuscation technique,contributing to the enhancement of software protection strategies in adversarial environments.展开更多
Active matter is a non-equilibrium condensed system consisting of self-propelled particles capable of converting stored or ambient energy into collective motion.Typical active matter systems include cytoskeleton biopo...Active matter is a non-equilibrium condensed system consisting of self-propelled particles capable of converting stored or ambient energy into collective motion.Typical active matter systems include cytoskeleton biopolymers,swimming bacteria,artificial swimmers,and animal herds.In contrast to wet active matter,dry active matter is an active system characterized by the absence of significant hydrodynamic interactions and conserved momentum.In dry active matter,the role of surrounding fluids is providing viscous friction at low Reynolds numbers and can be neglected at high Reynolds numbers.This review offers a comprehensive overview of recent experimental,computational,and theoretical advances in understanding phase transitions and critical phenomena in dry aligning active matter,including polar particles,self-propelled rods,active nematics,and their chiral counterparts.Various ways of determining phase transition points as well as non-equilibrium phenomena,such as collective motion,cluster formation,and creation and annihilation of topological defects are reviewed.展开更多
Mn_(3)Si_(2)Te_(6) is a ferrimagnetic nodal-line semiconductor with colossal angular magnetoresistance at ambient pressure.In this work,we investigated the effect of hydrostatic pressure on its electrical transport pr...Mn_(3)Si_(2)Te_(6) is a ferrimagnetic nodal-line semiconductor with colossal angular magnetoresistance at ambient pressure.In this work,we investigated the effect of hydrostatic pressure on its electrical transport properties,magnetic transition,and crystal structure by measuring resistivity,DC and AC magnetic susceptibility,and XRD under various pressures up to~20 GPa.Our results confirmed the occurrence of pressure-induced structural transition at P_(c)≈10–12 GPa accompanied by a concurrent drop of room-temperature resistance in Mn_(3)Si_(2)Te_(6).In the low-pressure phase at PP_(c),the sample exhibits a metallic behavior in the whole temperature range and its resistivity exhibits a kink anomaly at T_(M),characteristic of critical scattering around a magnetic transition.Recovery of the Raman spectrum upon decompression indicated that pressure-induced structural transition is reversible without amorphization under hydrostatic pressure conditions.Our present work not only resolves some existing controversial issues but also provides new insights into pressure-driven diverse behaviors of Mn_(3)Si_(2)Te_(6).展开更多
基金supported by the National Natural Science Foundation of China(Nos.51974056 and 51474047)the Foundation of the Supercomputing Center of Dalian University of Technology,and the Foundation of the Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province),China.
文摘Calculating the inter-layer ion diffusion barrier, a crucial metric for evaluating the rate performance of 2D electrode materials, is time-consuming using the transition state search approach. A novel electrostatic potential distribution image (EPDI) transfer learning method has been proposed to efficiently and accurately predict the lithium diffusion barriers on metal element-doped transition metal dichalcogenide (TMD) surfaces. Through the analysis of the mean electrostatic potential (MEP) around binding sites, a positive correlation between binding energy and MEP in VIB-TMDs was identified. Subsequently, transfer learning techniques were used to develop a DenseNet121-TL model for establishing a more accurate mapping between the binding energy and electrostatic potential distribution. Trained on training sets containing 33% and 50% transition state search calculation results, which save 66% and 50% of the calculation time, respectively, the model achieves accurate predictions of the saddle point binding energy with mean absolute errors (MAEs) of 0.0444 and 0.0287 eV on the testing set. Based on the prediction of saddle point binding energies, we obtained a diffusion minimum energy profile with an MAE of 0.0235 eV. Furthermore, by analyzing the diffusion data, we observed that the diffusion barrier was lowered by 10% on V-doped TiS2 compared to the stoichiometric surface. Our findings are expected to provide new insights for the high-throughput calculation of ion diffusion on 2D materials.
文摘Machine learning(ML)has emerged as a powerful tool for predicting polymer properties,including glass transition temperature(Tg),which is a critical factor influencing polymer applications.In this study,a dataset of polymer structures and their Tg values were created and represented as adjacency matrices based on molecular graph theory.Four key structural descriptors,flexibility,side chain occupancy length,polarity,and hydrogen bonding capacity,were extracted and used as inputs for ML models:Extra Trees(ET),Random Forest(RF),Gaussian Process Regression(GPR),and Gradient Boosting(GB).Among these,ET and GPR achieved the highest predictive performance,with R2 values of 0.97,and mean absolute errors(MAE)of approximately 7–7.5 K.The use of these extracted features significantly improved the prediction accuracy compared to previous studies.Feature importance analysis revealed that flexibility had the strongest influence on Tg,followed by side-chain occupancy length,hydrogen bonding,and polarity.This work demonstrates the potential of data-driven approaches in polymer science,providing a fast and reliable method for Tg prediction that does not require experimental inputs.
基金financially supported by the National Natural Science Foundation of China(U21B2082,52474410)the National Key R&D Program of China(2023YFB3709903,2020 YFA0714900)+5 种基金the Key R&D Program of Shandong Province,China(2023CXGC010406)the Scientific Research Special Project for First-Class Disciplines in Inner Mongolia Autonomous Region(YLXKZXNKD-001)the Natural Science Foundation of Inner Mongolia Autonomous Region of China(2024ZD06)the Technology Support Project for the Construction of Major Innovation Platforms in Inner Mongolia Autonomous Region(XM2024XTGXQ16)the Beijing Municipal Natural Science Foundation(2222065)the Fundamental Research Funds for the Central Universities(FRF-TP-22-02C2).
文摘The reactor pressure vessel(RPV)is susceptible to brittle fracture due to the influence of ion irradiation and high temperature,which presents a significant risk to the safe operation of nuclear reactors.It has been demonstrated that pulsed electric current can effectively address the issue of embrittlement in RPV steel.However,the relationship between pulse parameters(duty ratio,frequency,current,and time)and the effectiveness of pulse current processing has not been systematically studied.The application of machine learning methods enables autonomous exploration and learning of the relationship between data.Consequently,this study proposes a machine learning method based on the random forest model to establish the relationship between the parameters of electrical pulses and the repair effect of RPV steel.A generative adversarial network is employed to enhance data diversity and scalability,while a particle swarm optimization algorithm is utilized to optimize the initialization weights and biases of the random forest model,aiming to improve the model’s fitting ability and training performance.The results indicate that the coefficient of determination R-square(R^(2)),root mean squared error and mean absolute error values are 0.934,0.045,and 0.036,respectively,suggesting that the model has the potential to predict the performance recovery of RPV steel after pulsed electric field treatment.The prediction of the impact of pulse current parameters on the repair effect will help to enhance and optimize the repair process,thereby providing a scientific basis for pulse current repair processing.
基金the research committee at Malek Ashtar University of Technology (MUT) for their invaluable support of this project
文摘Recent advancements have led to the synthesis of various new metal-containing explosives,particularly energetic metal-organic frameworks(EMOFs),which feature high-energy ligands within well-ordered crystalline structures.These explosives exhibit significant advantages over traditional compounds,including higher density,greater heats of detonation,improved mechanical hardness,and excellent thermal stability.To effectively evaluate their detonation performance,it is crucial to have a reliable method for predicting detonation heat,velocity,and pressure.This study leverages experimental data and outputs from the leading commercial computer code to identify suitable decomposition pathways for different metal oxides,facilitating straightforward calculations for the detonation performance of alkali metal salts,and metal coordination compounds,along with EMOFs.The new model enhances predictive reliability for detonation velocities,aligning more closely with experimental results,as evi-denced by a root mean square error(RMSE)of 0.68 km/s compared to 1.12 km/s for existing methods.Furthermore,it accommodates a broader range of compounds,including those containing Sr,Cd,and Ag,and provides predictions for EMOFs that are more consistent with computer code outputs than previous predictive models.
文摘China Oil&Gas,as a prominent academic journal in the energy industry,has been dedicated to advancing academic research and industrial development in the oil and gas energy field.As one of the authoritative media outlets in the international energy sector,the magazine has long focused on the evolution of the global energy landscape and has organized and participated in several influential academic activities and research projects.
基金The National Natural Science Foundation of China(no.82204006)the Science and Technology of Project of Hebei Education Department(QN2022009)+1 种基金the Provincial Graduate Student Innovation Funding Project of Hebei Province(CXZZBS2022104)the National Natural Science Foundation of Hebei Province(H2020209292).
文摘Background:The aim was to explore the effect of macrophage polarization and macrophage-to-myofibroblast transition(MMT)in silicosis.Methods:Male Wistar rats were divided into a control group and a silicosis group developed using a HOPE MED 8050 dynamic automatic dusting system.Murine mac-rophage MH-S cells were randomly divided into a control group and an SiO_(2) group.The pathological changes in lung tissue were observed using hematoxylin and eosin(HE)and Van Gieson(VG)staining.The distribution and location of macrophage marker(F4/80),M1 macrophage marker(iNOS),M2 macrophage marker(CD206),and myofibroblast marker(α-smooth muscle actin[α-SMA])were detected using immu-nohistochemical and immunofluorescent staining.The expression changes in iNOS,Arg,α-SMA,vimentin,and type I collagen(Col I)were measured using Western blot.Results:The results of HE and VG staining showed obvious silicon nodule formation and the distribution of thick collagen fibers in the lung tissue of the silicosis group.Macrophage marker F4/80 increased gradually from 8 to 32 weeks after exposure to silica.Immunohistochemical and immunofluorescent staining results revealed that there were more iNOS-positive cells and some CD206-positive cells in the lung tissue of the silicosis group at 8 weeks.More CD206-positive cells were found in the silicon nodules of the lung tissues in the silicosis group at 32 weeks.Western blot analysis showed that the expressions of Inducible nitric oxide synthase and Arg protein in the lung tissues of the silicosis group were upregulated compared with those of the con-trol group.The results of immunofluorescence staining showed the co-expression of F4/80,α-SMA,and Col I,and CD206 andα-SMA were co-expressed in the lung tissue of the silicosis group.The extracted rat alveolar lavage fluid revealed F4/80+α-SMA+,CD206+α-SMA+,and F4/80+α-SMA+Col I+cells using immunofluorescence staining.Similar results were also found in MH-S cells induced by SiO_(2).Conclusions:The development of silicosis is accompanied by macrophage polarization and MMT.
基金supported by the National Natural Science Foundation of China(Grant Nos.82172728,82370096).
文摘In the present study,we aimed to investigate whether anlotinib reverses osimertinib resistance by inhibiting the formation of epithelial-mesenchymal transition(EMT)and angiogenesis.In a clinical case,anlotinib reversed osimertinib resistance in non-small cell lung cancer(NSCLC).Therefore,we performed immunohistochemical analyses on tumor tissues from three NSCLC patients with osimertinib resistance to analyze alterations in the expression levels of EMT markers and vascular endothelial growth factor A(VEGFA)before and after the development of osimertinib resistance.The results revealed the downregulation of E-cadherin,coupled with the upregulation of vimentin and VEGFA in tumor tissues of patients exhibiting osimertinib resistance,compared with those in tissues from patients before receiving osimertinib.Subsequently,we established osimertinib-resistant(Osi-R)cell lines and found that the Osi-R cells acquired EMT features.Next,we analyzed the synergistic effects of the combination therapy to verify whether anlotinib could reverse osimertinib resistance by inhibiting EMT.The expression levels of VEGFA and tube formation were analyzed in the combination group in vitro.Finally,we determined the reversal of osimertinib resistance by the combination of osimertinib and anlotinib in vivo using 20 nude mice.The combined treatment of osimertinib and anlotinib effectively prevented the metastasis of Osi-R cells,inhibited tumor growth,exerted antitumor activity,and ultimately reversed osimertinib resistance in mice.The co-administration of osimertinib and anlotinib demonstrated synergistic efficacy in inhibiting EMT and angiogenesis in three NSCLC patients,ultimately reversing osimertinib resistance.
基金National Key Research and Development Program of China(2021YFB3101402)National Natural Science Foundation of China(62202294)。
文摘This study constructs a function-private inner-product predicate encryption(FP-IPPE)and achieves standard enhanced function privacy.The enhanced function privacy guarantees that a predicate secret key skf reveals nothing about the predicate f,as long as f is drawn from an evasive distribution with sufficient entropy.The proposed scheme extends the group-based public-key function-private predicate encryption(FP-PE)for“small superset predicates”proposed by Bartusek et al.(Asiacrypt 19),to the setting of inner-product predicates.This is the first construction of public-key FP-PE with enhanced function privacy security beyond the equality predicates,which is previously proposed by Boneh et al.(CRYPTO 13).The proposed construction relies on bilinear groups,and the security is proved in the generic bilinear group model.
基金Supported by the Fundamental Research Funds for the Central Universities(ZYGX2021J008)。
文摘A novel substrate integrated microstrip to ultra-thin cavity filter transition operating in the W-band is proposed in this letter.The structure is a new method of connecting microstrip circuits and waveguide filters,and this new structure enables a planar integrated transition from microstrip lines to ultra-thin cavity filters,thereby reducing the size of the transition structure and achieving miniaturization.The structure includes a conventional tapered microstrip transition structure,which guides the electromagnetic field from the microstrip line to the reduced-height dielectric-filled waveguide,and an air-filled matching cavity which is placed between the dielectric-filled waveguide and the ultra-thin cavity filter.The heights of the microstrip line,the dielectric-filled waveguide and the ultra-thin cavity filter are the same,enabling seamless integration within a planar radio-frequency(RF)circuit.To facilitate testing,mature finline transition structures are integrated at both ends of the microstrip line during fabrications.The simulation results of the fabricated microstrip to ultra-thin cavity filter transition with the finline transition structure,with a passband of 91.5-96.5 GHz,has an insertion loss of less than 1.9 dB and a return loss lower than-20 dB.And the whole structure has also been measured which achieves an insertion loss less than 2.6 dB and a return loss lower than-15 dB within the filter's passband,including the additional insertion loss introduced by the finline transitions.Finally,a W-band compact up-conversion module is designed,and the test results show that after using the proposed structure,the module achieves 95 dBc suppression of the 84 GHz local oscillator.It is also demonstrated that the structure proposed in this letter achieves miniaturization of the system integration without compromising the filter performance.
文摘Introduction and Background: Registered nurses’ transit to the clinical placement areas after completing a three-year Bachelor of Nursing training. They should be supported by nurse leaders and nurse educators;to gain confidence and the ability to perform critical care nursing, deal with high patient numbers, the ability to work independently and manage relationships with providers, families and the interprofessional team. Methods: A qualitative research design was employed to explore two important aspects of nursing professionalism. Firstly, the sentiments of senior registered nurses about professional mentorship of newly graduated nurses NGNs. Secondly the strategies employed by senior nurses to assist the transition of NGNs to professional nursing. Two nurse unit managers (NUM) participated as key informants. Results: Two themes will be discussed from the pilot study: Responsibilities and challenges faced by senior nurses while they supervise (NGNs) in their wards. Senior nurses’ workload and responsibilities fully occupy them during the days’ work, leaving very little time to spend supervising the NGNs. The challenges faced by senior nurses are those of restricted time, no proper resources, and mentoring manuals to guide the senior nurses. Discussion: The results of the pilot study present the challenges of senior nurses in supervising and training NGNs during transition, as they must complete the administrative tasks, finalizing rosters, and have direct patient contact. They usually face challenges while supervising the NGNs, sometimes leaving them to work on their own where the NGN is prone to make mistakes during patient care. Conclusion: Support and supervision are key to a successful transition, but senior nurses face difficulties, and challenges in many forms, there are no mentors available for the NGNs in any ward at the CWM Hospital while they train and supervise them during transitions. SNs take up a lot of responsibilities and provide support and supervision to NGNs. Some NGNs have undesirable attitudes that hinder the learning and teaching process. They also acknowledge that NGNs also need to play their role in learning to adapt to the new clinical environment with various challenges they face themselves.
基金supported by the National Natural Science Foundation of China(No.21805018)by Sichuan Science and Technology Program(Nos.2022ZHCG0018,2023NSFSC0117 and 2023ZHCG0060)Yibin Science and Technology Program(No.2022JB005)and China Postdoctoral Science Foundation(No.2022M722704).
文摘Layered transition metal oxides have emerged as promising cathode materials for sodium ion batteries.However,irreversible phase transitions cause structural distortion and cation rearrangement,leading to sluggish Na+dynamics and rapid capacity decay.In this study,we propose a medium-entropy cathode by simultaneously introducing Fe,Mg,and Li dopants into a typical P2-type Na_(0.75)Ni_(0.25)Mn_(0.75)O_(2)cathode.The modified Na_(0.75)Ni_(0.2125)Mn_(0.6375)Fe_(0.05)Mg_(0.05)Li_(0.05)O_(2)cathode predominantly exhibits a main P2 phase(93.5%)with a minor O3 phase(6.5%).Through spectroscopy techniques and electrochemical investigations,we elucidate the redox mechanisms of Ni^(2+/3+/4+),Mn^(3+/4+),Fe^(3+/4+),and O_(2)-/O_(2)^(n-)during charging/discharging.The medium-entropy doping mitigates the detrimental P2-O_(2)phase transition at high-voltage,replacing it with a moderate and reversible structural evolution(P2-OP4),thereby enhancing structural stability.Consequently,the modified cathode exhibits a remarkable rate capacity of 108.4 mAh·g^(-1)at 10C,with a capacity retention of 99.0%after 200 cycles at 1C,82.5%after 500 cycles at 5C,and 76.7%after 600 cycles at 10C.Furthermore,it also demonstrates superior electrochemical performance at high cutoff voltage of 4.5 V and extreme temperature(55 and 0℃).This work offers solutions to critical challenges in sodium ion batteries cathode materials.
基金Supported by the Fundamental Research Program of Shanxi Province,No.202203021222418Research Program of Shanxi Provincial Health Commission,No.2023061+2 种基金Fundamental Research Cooperation Program of Beijing-Tianjin-Hebei Region of Natural Science Foundation of Tianjin,No.22JCZXJC00140Tianjin Major Science and Technology Project,No.21ZXJBSY00110Tianjin Health and Science and Technology Project,No.TJWJ2024ZK001.
文摘BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G proteins.The speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet clear.AIM To explore the role and underlying mechanisms of action of RGS4 in GC develop-ment.METHODS The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with GC.Function assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in vitro.RESULTS RGS4 was highly expressed in GC tissues compared with matched adjacent normal tissues.Elevated RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with GC.Cell experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and invasion.Similarly,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor growth.Moreover,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated E-cadherin.CONCLUSION High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic marker.RGS4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.
文摘Background: Since it was theorised by Abdel Omran in 1971, the epidemiological transition has been well documented in Latin America, Asia and even increasingly in Africa south of the Sahara. According to this theory, sub-Saharan Africa is in the first phase of development corresponding to the “age of plague and famine”. Given the health statistics currently available, more and more low- and middle-income countries, including those in sub-Saharan Africa, are experiencing an increase in mortality and the economic impact associated with non-communicable diseases. Côte d’Ivoire is one of the countries in sub-Saharan Africa where non-communicable diseases are currently on the rise. Despite the significant changes observed over the last decades, few studies have been carried out on the epidemiological transition in Côte d’Ivoire. It therefore seemed necessary to examine the changes in patterns of disease occurrence and causes of death in Côte d’Ivoire. Objectives: This work aimed to determine the reality of the epidemiological transition in Côte d’Ivoire and characterize its facies from 1990 to 2020. Methods: A literature review was carried out using PubMed, Medline, Google Scholar, Google, institutional websites (WHO, World Bank), university library websites and institutional reports from Côte d’Ivoire. The indicators sought were mortality, morbidity, life expectancy and fertility. Results: Mortality fell overall from 13.88‰ to 9.70‰, with variations linked to cyclical situations. Life expectancy rose by 52.6 to 59.03 years, although it is still below 60. Fertility has fallen from 6.3 to 4.5 children. There is a general downward trend in morbidity due to communicable diseases between 2009 and 2019, followed by an increase in non-communicable diseases. Conclusion: Côte d’Ivoire is undergoing an original and complex epidemiological transition that needs to be taken into account in health policies and strategies.
基金supported by Hebei Natural Science Foundation under Grant No.E2024402079Key Laboratory of Intelligent Industrial Equipment Technology of Hebei Province(Hebei University of Engineering)under Grant No.202206.
文摘A bearing fault diagnosis method based on the Markov transitionfield(MTF)and SEnet(SE)-IShufflenetV2 model is proposed in this paper due to the problems of complex working conditions,low fault diagnosis accuracy,and poor generalization of rolling bearing.Firstly,MTF is used to encode one-dimensional time series vibration sig-nals and convert them into time-dependent and unique two-dimensional feature images.Then,the generated two-dimensional dataset is fed into the SE-IShufflenetV2 model for training to achieve fault feature extraction and classification.This paper selects the bearing fault datasets from Case Western Reserve University and Paderborn University to experimentally verify the effectiveness and superiority of the proposed method.The generalization performance of the proposed method is tested under the variable load condition and different signal-to-noise ratios(SNRs).The experimental results show that the average accuracy of the proposed method under different working conditions is 99.2%without adding noise.The accuracy under different working conditions from 0 to 1 HP is 100%.When the SNR is 0 dB,the average accuracy of the proposed method can still reach 98.7%under varying working conditions.Therefore,the bearing fault diagnosis method proposed in this paper is characterized by high accuracy,strong anti-noise ability,and generalization.Moreover,the proposed method can also overcome the influence of variable working conditions on diagnosis accuracy,providing method support for the accurate diagnosis of bearing faults under strong noise and variable working conditions.
基金supported by the National Natural Science Foundation of China(Nos.22206207,22127810,and 22276224)the Natural Science Foundation of Guangdong Province(Nos.2021A1515011546 and 2023A1515010085)the Science and Technology Planning Project of Guangzhou(No.202102080005)。
文摘Epithelial-mesenchymal transition(EMT)plays an irreplaceable role in the development of silicosis.However,molecular mechanisms of EMT induced by silica exposure still remain to be addressed.Herein,metabolic profiles of human alveolar type II epithelial cells(A549 cells)exposed directly to silica were characterized using non-targeted metabolomic approaches.A total of 84 differential metabolites(DMs)were identified in silica-treated A549 cells undergoing EMT,which were mainly enriched in metabolisms of amino acids(e.g.,glutamate,alanine,aspartate),purine metabolism,glycolysis,etc.The number of DMs identified in the A549 cells obviously increased with the elevated exposure concentration of silica.Remarkably,glutamine catabolism was significantly promoted in the silica-treated A549 cells,and the levels of related metabolites(e.g.,succinate)and enzymes(e.g.,α-ketoglutarate(α-KG)dehydrogenase)were substantially up-regulated,with a preference toα-KG pathway.Supplementation of glutamine into the cell culture could substantially enhance the expression levels of both EMT-related markers and Snail(zinc finger transcription factor).Our results suggest that the EMT of human alveolar epithelial cells directly induced by silica can be essential to the development of silicosis.
基金National Natural Science Foundation of China(52375378)National Key Laboratory of Metal Forming Technology and Heavy Equipment(S2308100.W12)Huxiang High-Level Talent Gathering Project of Hunan Province(2021RC5001)。
文摘The pressure-actuated metal seal with soft metal coating has been widely used in complex working conditions such as high temperature,low temperature and high pressure.The investigation of the characteristics and binding strength of the transition layer between the soft metal coating and the superalloy substrate is important to improve the sealing performance and to model and simplify the working through-process of metal sealing.The distribution characteristics of elements at soft metal-substrate interface and the binding strength between coating and substrate under different thicknesses and material combinations of coating layer were studied by experimental methods.The results indicate that the thickness of soft metal coating has little influence on the interface morphology of GH4169-Cu,GH4169-Ag and Cu-Ag,but has an influence on the thickness of transition layer between different metals,while this influence is weakened with increasing the coating thickness,and the thickness of transition layer is about 2μm when the coating thickness is more than 30μm.The cross-cut test shows that the Cu,Ag and Cu-Ag coatings are all well combined with nickel-based superalloy GH4169 substrate.The materials of soft metal,i.e.the coating materials,have significant influence on the characteristic of transition layer and the surface characteristics of coating after cross-cut test.
文摘Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing up.These normal experiences are potentially magnified for teenagers living with chronic illness or disability and their families.Advances in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing morbidity.For those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of life.At the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general hospitals.While there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive care.Many patients may encounter considerable challenges during this period.Difficulties may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric conditions.In addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health issues.These challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.
基金supported byOpen Foundation of Key Laboratory of Cyberspace Security,Ministry of Education of China(No.KLCS20240211)Henan Science and Technology Major Project No.241110210100.
文摘Code obfuscation is a crucial technique for protecting software against reverse engineering and security attacks.Among various obfuscation methods,opaque predicates,which are recognized as flexible and promising,are widely used to increase control-flow complexity.However,traditional opaque predicates are increasingly vulnerable to Dynamic Symbolic Execution(DSE)attacks,which can efficiently identify and eliminate them.To address this issue,this paper proposes a novel approach for anti-DSE opaque predicates that effectively resists symbolic execution-based deobfuscation.Our method introduces two key techniques:single-way function opaque predicates,which leverage hash functions and logarithmic transformations to prevent constraint solvers from generating feasible inputs,and path-explosion opaque predicates,which generate an excessive number of execution paths,overwhelming symbolic execution engines.To evaluate the effectiveness of our approach,we implemented a prototype obfuscation tool and tested it against prominent symbolic execution engines.Experimental results demonstrate that our approach signifi-cantly increases resilience against symbolic execution attacks while maintaining acceptable performance overhead.This paper provides a robust and scalable obfuscation technique,contributing to the enhancement of software protection strategies in adversarial environments.
基金granted by the National Natural Science Foundation of China(No.12047503)Wenzhou Institute,University of Chinese Academy of Sciences(No.WIUCASQD2023009)。
文摘Active matter is a non-equilibrium condensed system consisting of self-propelled particles capable of converting stored or ambient energy into collective motion.Typical active matter systems include cytoskeleton biopolymers,swimming bacteria,artificial swimmers,and animal herds.In contrast to wet active matter,dry active matter is an active system characterized by the absence of significant hydrodynamic interactions and conserved momentum.In dry active matter,the role of surrounding fluids is providing viscous friction at low Reynolds numbers and can be neglected at high Reynolds numbers.This review offers a comprehensive overview of recent experimental,computational,and theoretical advances in understanding phase transitions and critical phenomena in dry aligning active matter,including polar particles,self-propelled rods,active nematics,and their chiral counterparts.Various ways of determining phase transition points as well as non-equilibrium phenomena,such as collective motion,cluster formation,and creation and annihilation of topological defects are reviewed.
基金supported by the National Key R&D Program of China (Grant Nos. 2023YFA1406100, 2022YFA1403900, 2024YFA1408400, 2021YFA1400200, 2022YFA1403800, and 2023YFA1406500)the National Natural Science Foundation of China (Grant Nos. 12174424, 12025408, 11921004, U22A6005, and 12274459)+1 种基金the Youth Innovation Promotion Association of Chinese Academy of Sciences (Grant No. 2023007)the Chinese Academy of Sciences President’s International Fellowship Initiative (Grant No. 2024PG0003)。
文摘Mn_(3)Si_(2)Te_(6) is a ferrimagnetic nodal-line semiconductor with colossal angular magnetoresistance at ambient pressure.In this work,we investigated the effect of hydrostatic pressure on its electrical transport properties,magnetic transition,and crystal structure by measuring resistivity,DC and AC magnetic susceptibility,and XRD under various pressures up to~20 GPa.Our results confirmed the occurrence of pressure-induced structural transition at P_(c)≈10–12 GPa accompanied by a concurrent drop of room-temperature resistance in Mn_(3)Si_(2)Te_(6).In the low-pressure phase at PP_(c),the sample exhibits a metallic behavior in the whole temperature range and its resistivity exhibits a kink anomaly at T_(M),characteristic of critical scattering around a magnetic transition.Recovery of the Raman spectrum upon decompression indicated that pressure-induced structural transition is reversible without amorphization under hydrostatic pressure conditions.Our present work not only resolves some existing controversial issues but also provides new insights into pressure-driven diverse behaviors of Mn_(3)Si_(2)Te_(6).
