Background Proneurotrophins such as the precursor of nerve growth factor （proNGF） and the precursor of brain-derived neurotrophic factor （proBDNF） interacted with sortilin and p75NTR to form a complex capable of a...Background Proneurotrophins such as the precursor of nerve growth factor （proNGF） and the precursor of brain-derived neurotrophic factor （proBDNF） interacted with sortilin and p75NTR to form a complex capable of activating an apoptotic signaling. We found that the expression of p75NTR and sortilin was increased in ischemic retina induced by elevated intraocular pressure （lOP）, but the protein expression changes of proNGF and proBDNF in the same situation were not clear. This study aimed to ascertain the protein expression changes of proNGF and proBDNF in ischemic retina induced by elevated lOP.展开更多
基金This study was supported in part from grants of National Natural Science Foundation of China （No. 30973261 and No. 30571991）.
文摘Background Proneurotrophins such as the precursor of nerve growth factor （proNGF） and the precursor of brain-derived neurotrophic factor （proBDNF） interacted with sortilin and p75NTR to form a complex capable of activating an apoptotic signaling. We found that the expression of p75NTR and sortilin was increased in ischemic retina induced by elevated intraocular pressure （lOP）, but the protein expression changes of proNGF and proBDNF in the same situation were not clear. This study aimed to ascertain the protein expression changes of proNGF and proBDNF in ischemic retina induced by elevated lOP.
