The ever-expanding development of tissue-agnostic therapies which target malignancies based on specific mutations rather than tissue origin have transformed the landscape of oncology.The purpose of this review is to e...The ever-expanding development of tissue-agnostic therapies which target malignancies based on specific mutations rather than tissue origin have transformed the landscape of oncology.The purpose of this review is to explore the impact,safety,and challenges of tissue-agnostic therapies including pembrolizumab,dostarlimab,larotrectinib,entrectinib,repotrectinib,dabrafenib plus trametinib,selpercatinib,and trastuzumab deruxtecan.As the therapeutic arsenal continues to grow,it is crucial to understand how these therapies truly benefit patients and to address the barriers that stand in the way of making them more widely available.Although these therapies have shown effectiveness across multiple cancer types,substantial challenges persist,including overcoming the burden of intratumoral heterogeneity and resistance mechanisms that reduce therapeutic efficacy.We discuss emergence of pan-histological biomarkers,such as neoantigen burden,current updates on trials as well as trial outlining strategies to refining patient selection,while also supporting broader access to biomarker testing.Collectively,these insights underscore the transformative role of tissue-agnostic therapies in precision oncology while emphasizing the ongoing need for research to optimize their application and overcome current barriers.展开更多
In recent years,the compact development of high-density cities has sparked ongoing interest in healthy urban environments and public well-being.This study examines the relationship between cycling behaviors and the bu...In recent years,the compact development of high-density cities has sparked ongoing interest in healthy urban environments and public well-being.This study examines the relationship between cycling behaviors and the built environment of streets in Tiantongyuan Community,a typical high-density area in Beijing,China.By observing street spaces and summarizing residents’travel modes and behaviors,the study evaluates the impact of street design on cycling habits.In order to reveal the riding behavior characteristics of residents in different time periods and different street spaces,tools such as track recording APPs and the Gopro Motion Camera are employed to collect street view pictures and riding track data comprehensively,analyzing the various travel purposes of residents in Tiantongyuan community and the riding OD activity tracks of the main entrances and exits of the community.Meanwhile,by conducting the questionnaire survey of residents’travel demands and OD data of Baidu,and utilizing geographic information system(GIS)for data visualization,this study further investigates the distribution characteristics of cycling hotspots,cycling paths and cycling space,accurately identifies the cycling life circle of this community based on the spatial and temporal scales,and further puts forward the optimization strategy of the cycling network.Some cycling-friendly street space optimization strategies are suggested to deeply analyze the mechanism of the built environment of street space in high-density communities on the cycling activities and health of urban residents,with a view to provide accurate data support for the renewal of street cycling space.展开更多
文摘The ever-expanding development of tissue-agnostic therapies which target malignancies based on specific mutations rather than tissue origin have transformed the landscape of oncology.The purpose of this review is to explore the impact,safety,and challenges of tissue-agnostic therapies including pembrolizumab,dostarlimab,larotrectinib,entrectinib,repotrectinib,dabrafenib plus trametinib,selpercatinib,and trastuzumab deruxtecan.As the therapeutic arsenal continues to grow,it is crucial to understand how these therapies truly benefit patients and to address the barriers that stand in the way of making them more widely available.Although these therapies have shown effectiveness across multiple cancer types,substantial challenges persist,including overcoming the burden of intratumoral heterogeneity and resistance mechanisms that reduce therapeutic efficacy.We discuss emergence of pan-histological biomarkers,such as neoantigen burden,current updates on trials as well as trial outlining strategies to refining patient selection,while also supporting broader access to biomarker testing.Collectively,these insights underscore the transformative role of tissue-agnostic therapies in precision oncology while emphasizing the ongoing need for research to optimize their application and overcome current barriers.
文摘In recent years,the compact development of high-density cities has sparked ongoing interest in healthy urban environments and public well-being.This study examines the relationship between cycling behaviors and the built environment of streets in Tiantongyuan Community,a typical high-density area in Beijing,China.By observing street spaces and summarizing residents’travel modes and behaviors,the study evaluates the impact of street design on cycling habits.In order to reveal the riding behavior characteristics of residents in different time periods and different street spaces,tools such as track recording APPs and the Gopro Motion Camera are employed to collect street view pictures and riding track data comprehensively,analyzing the various travel purposes of residents in Tiantongyuan community and the riding OD activity tracks of the main entrances and exits of the community.Meanwhile,by conducting the questionnaire survey of residents’travel demands and OD data of Baidu,and utilizing geographic information system(GIS)for data visualization,this study further investigates the distribution characteristics of cycling hotspots,cycling paths and cycling space,accurately identifies the cycling life circle of this community based on the spatial and temporal scales,and further puts forward the optimization strategy of the cycling network.Some cycling-friendly street space optimization strategies are suggested to deeply analyze the mechanism of the built environment of street space in high-density communities on the cycling activities and health of urban residents,with a view to provide accurate data support for the renewal of street cycling space.
