Based on the concept of ＂precision medicine＂, this paper is to probe into the thinking innovation thought anddevelopment direction of ＂dialectical theory＂ of TCM, and to compare the development prospects of ＂synd...Based on the concept of ＂precision medicine＂, this paper is to probe into the thinking innovation thought anddevelopment direction of ＂dialectical theory＂ of TCM, and to compare the development prospects of ＂syndromedifferentiation＂ and ＂genetic constitution＂. It points out that the dialectical concept of ＂syndrome differentiation andtreatment＂ is combined with the concept of high and new technology of ＂precision medicine＂ to further clarify thescientific connotation of traditional Chinese medicine.展开更多
Medical genetics is defined as a branch of medicine that involves the diagnosis and management of hereditary disorders by applying genetics to medical care.The Human Genome Project,initiated in1990 and completed in 20...Medical genetics is defined as a branch of medicine that involves the diagnosis and management of hereditary disorders by applying genetics to medical care.The Human Genome Project,initiated in1990 and completed in 2004,has profoundly changed biology and is rapidly catalyzing a transformation of medical genetics and medicine in general（Collins and McKusick,2001;Green and Guyer,2011）.展开更多
Drug resistance is one of the key factors affecting the effectiveness of cancer treatment methods,including chemotherapy,radiotherapy,and immunotherapy.Its occurrence is related to factors such as mRNA expression and ...Drug resistance is one of the key factors affecting the effectiveness of cancer treatment methods,including chemotherapy,radiotherapy,and immunotherapy.Its occurrence is related to factors such as mRNA expression and methylation within cancer cells.If drug resistance in patients can be accurately identified early,doctors can devise more effective treatment plans,which is of great significance for improving patients'survival rates and quality of life.Cancer drug resistance prediction based on artificial intelligence(AI)technology has emerged as a current research hotspot,demonstrating promising application prospects in guiding clinical individualized and precise medication for cancer patients.This review aims to comprehensively summarize the research progress in utilizing AI algorithms to analyze multi-omics data including genomics,transcriptomics,epigenomics,proteomics,metabolomics,radiomics,and histopathology,for predicting cancer drug resistance.It provides a detailed exposition of the processes involved in data processing and model construction,examines the current challenges faced in this field and future development directions,with the aim of better advancing the progress of precision medicine.展开更多
文摘Based on the concept of ＂precision medicine＂, this paper is to probe into the thinking innovation thought anddevelopment direction of ＂dialectical theory＂ of TCM, and to compare the development prospects of ＂syndromedifferentiation＂ and ＂genetic constitution＂. It points out that the dialectical concept of ＂syndrome differentiation andtreatment＂ is combined with the concept of high and new technology of ＂precision medicine＂ to further clarify thescientific connotation of traditional Chinese medicine.
文摘Medical genetics is defined as a branch of medicine that involves the diagnosis and management of hereditary disorders by applying genetics to medical care.The Human Genome Project,initiated in1990 and completed in 2004,has profoundly changed biology and is rapidly catalyzing a transformation of medical genetics and medicine in general（Collins and McKusick,2001;Green and Guyer,2011）.
基金supported by the National Natural Science Foundation of China(No.82404186)the China Postdoctoral Science Foundation(No.2023M743947,China)+2 种基金the Postdoctoral Fellowship Program of CPSF(No.GZB20240869,China)the Hunan Provincial Natural Science Foundation of China(Nos.2024JJ6697 and 2025JJ40074)the Changsha Natural Science Foundation(No.kq2403026,China).
文摘Drug resistance is one of the key factors affecting the effectiveness of cancer treatment methods,including chemotherapy,radiotherapy,and immunotherapy.Its occurrence is related to factors such as mRNA expression and methylation within cancer cells.If drug resistance in patients can be accurately identified early,doctors can devise more effective treatment plans,which is of great significance for improving patients'survival rates and quality of life.Cancer drug resistance prediction based on artificial intelligence(AI)technology has emerged as a current research hotspot,demonstrating promising application prospects in guiding clinical individualized and precise medication for cancer patients.This review aims to comprehensively summarize the research progress in utilizing AI algorithms to analyze multi-omics data including genomics,transcriptomics,epigenomics,proteomics,metabolomics,radiomics,and histopathology,for predicting cancer drug resistance.It provides a detailed exposition of the processes involved in data processing and model construction,examines the current challenges faced in this field and future development directions,with the aim of better advancing the progress of precision medicine.
