Activity cliffs(ACs)are generally defined as pairs of similar compounds that only differ by a minor structural modification but exhibit a large difference in their binding affinity for a given target.ACs offer crucial...Activity cliffs(ACs)are generally defined as pairs of similar compounds that only differ by a minor structural modification but exhibit a large difference in their binding affinity for a given target.ACs offer crucial insights that aid medicinal chemists in optimizing molecular structures.Nonetheless,they also form a major source of prediction error in structure-activity relationship(SAR)models.To date,several studies have demonstrated that deep neural networks based on molecular images or graphs might need to be improved further in predicting the potency of ACs.In this paper,we integrated the triplet loss in face recognition with pre-training strategy to develop a prediction model ACtriplet,tailored for ACs.Through extensive comparison with multiple baseline models on 30 benchmark datasets,the results showed that ACtriplet was significantly better than those deep learning(DL)models without pretraining.In addition,we explored the effect of pre-training on data representation.Finally,the case study demonstrated that our model's interpretability module could explain the prediction results reasonably.In the dilemma that the amount of data could not be increased rapidly,this innovative framework would better make use of the existing data,which would propel the potential of DL in the early stage of drug discovery and optimization.展开更多
How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classif...How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classification due to the powerful feature representation ability and better performance. However,the training and testing of CNN mainly rely on single machine.Single machine has its natural limitation and bottleneck in processing RSIs due to limited hardware resources and huge time consuming. Besides, overfitting is a challenge for the CNN model due to the unbalance between RSIs data and the model structure.When a model is complex or the training data is relatively small,overfitting occurs and leads to a poor predictive performance. To address these problems, a distributed CNN architecture for RSIs target classification is proposed, which dramatically increases the training speed of CNN and system scalability. It improves the storage ability and processing efficiency of RSIs. Furthermore,Bayesian regularization approach is utilized in order to initialize the weights of the CNN extractor, which increases the robustness and flexibility of the CNN model. It helps prevent the overfitting and avoid the local optima caused by limited RSI training images or the inappropriate CNN structure. In addition, considering the efficiency of the Na¨?ve Bayes classifier, a distributed Na¨?ve Bayes classifier is designed to reduce the training cost. Compared with other algorithms, the proposed system and method perform the best and increase the recognition accuracy. The results show that the distributed system framework and the proposed algorithms are suitable for RSIs target classification tasks.展开更多
Vision-Language-Navigation(VLN) task is a cross-modality task that combines natural language processing and computer vision. This task requires the agent to automatically move to the destination according to the natur...Vision-Language-Navigation(VLN) task is a cross-modality task that combines natural language processing and computer vision. This task requires the agent to automatically move to the destination according to the natural language instruction and the observed surrounding visual information. To make the best decision, in every step during the navigation, the agent should pay more attention to understanding the objects, the object attributes, and the object relationships. But most current methods process all received textual and visual information equally. Therefore, this paper integrates more detailed semantic connections between visual and textual information through three pre-training tasks(object prediction, object attributes prediction, and object relationship prediction). The model will learn better fusion representation and alignment between these two types of information to improve the success rate(SR) and generalization. The experiments show that compared with the former baseline models, the SR on the unseen validation set(Val Unseen) increased by 7%, and the SR weighted by path length(SPL) increased by 7%;the SR on the test set(Test) increased 4%, SPL increased by 3%.展开更多
Web-based training is growing quickly in popularit y for professionals in industrial organizations and large enterprises. The savings in cost and time are significant. The instructor-led trainings are bounded by time ...Web-based training is growing quickly in popularit y for professionals in industrial organizations and large enterprises. The savings in cost and time are significant. The instructor-led trainings are bounded by time and place, not to mention the cost involved in traveling, accommodation and training venue. However, in the most online training courses, all trainees are given same training materials and teaching paradigms. The problem of differentia ting the trainees’ abilities is the main concern. We need a pre-training test t o identify and classify of the weaknesses and strengths of differentiate trainee s so as to devise an appropriate training programs for the trainees. Adaptation of a Web-based Computer adaptive Test (CAT) for the pre-training test make the web-based training more efficient. The advantages of CAT are self-pacing, eff iciency, time and cost saving, immediate scoring and feedback, accuracy and secu rity, etc (Rudner, 1998; UMN, 1999; Novell, 2000; Linacre, 2000; Windowsglore, 2 000). Moreover, Web-based CAT also gives greater flexibility and convenience. T his paper describes how this CAT tool is built, how it helps instructor identify the strengths and weaknesses of trainees, and how to assure quality on the CAT system.展开更多
Handheld ultrasound devices are known for their portability and affordability,making them widely utilized in underdeveloped areas and community healthcare for rapid diagnosis and early screening.However,the image qual...Handheld ultrasound devices are known for their portability and affordability,making them widely utilized in underdeveloped areas and community healthcare for rapid diagnosis and early screening.However,the image quality of handheld ultrasound devices is not always satisfactory due to the limited equipment size,which hinders accurate diagnoses by doctors.At the same time,paired ultrasound images are difficult to obtain from the clinic because imaging process is complicated.Therefore,we propose a modified cycle generative adversarial network(cycleGAN) for ultrasound image enhancement from multiple organs via unpaired pre-training.We introduce an ultrasound image pre-training method that does not require paired images,alleviating the requirement for large-scale paired datasets.We also propose an enhanced block with different structures in the pre-training and fine-tuning phases,which can help achieve the goals of different training phases.To improve the robustness of the model,we add Gaussian noise to the training images as data augmentation.Our approach is effective in obtaining the best quantitative evaluation results using a small number of parameters and less training costs to improve the quality of handheld ultrasound devices.展开更多
As important geological data,a geological report contains rich expert and geological knowledge,but the challenge facing current research into geological knowledge extraction and mining is how to render accurate unders...As important geological data,a geological report contains rich expert and geological knowledge,but the challenge facing current research into geological knowledge extraction and mining is how to render accurate understanding of geological reports guided by domain knowledge.While generic named entity recognition models/tools can be utilized for the processing of geoscience reports/documents,their effectiveness is hampered by a dearth of domain-specific knowledge,which in turn leads to a pronounced decline in recognition accuracy.This study summarizes six types of typical geological entities,with reference to the ontological system of geological domains and builds a high quality corpus for the task of geological named entity recognition(GNER).In addition,Geo Wo BERT-adv BGP(Geological Word-base BERTadversarial training Bi-directional Long Short-Term Memory Global Pointer)is proposed to address the issues of ambiguity,diversity and nested entities for the geological entities.The model first uses the fine-tuned word granularitybased pre-training model Geo Wo BERT(Geological Word-base BERT)and combines the text features that are extracted using the Bi LSTM(Bi-directional Long Short-Term Memory),followed by an adversarial training algorithm to improve the robustness of the model and enhance its resistance to interference,the decoding finally being performed using a global association pointer algorithm.The experimental results show that the proposed model for the constructed dataset achieves high performance and is capable of mining the rich geological information.展开更多
Intelligent sorting is an important prerequisite for the full quantitative consumption and harmless disposal of kitchen waste.The existing object detection method based on an ImageNet pre-trained model is an effective...Intelligent sorting is an important prerequisite for the full quantitative consumption and harmless disposal of kitchen waste.The existing object detection method based on an ImageNet pre-trained model is an effective way of sorting.Owing to significant domain gaps between natural images and kitchen waste images,it is difficult to reflect the characteristics of diverse scales and dense distribution in kitchen waste based on an ImageNet pre-trained model,leading to poor generalisation.In this article,the authors propose the first pre-trained model for kitchen waste sorting called KitWaSor,which combines both contrastive learning(CL)and masked image modelling(MIM)through self-supervised learning(SSL).First,to address the issue of diverse scales,the authors propose a mixed masking strategy by introducing an incomplete masking branch based on the original random masking branch.It prevents the complete loss of small-scale objects while avoiding excessive leakage of large-scale object pixels.Second,to address the issue of dense distribution,the authors introduce semantic consistency constraints on the basis of the mixed masking strategy.That is,object semantic reasoning is performed through semantic consistency constraints to compensate for the lack of contextual information.To train KitWaSor,the authors construct the first million-level kitchen waste dataset across seasonal and regional distributions,named KWD-Million.Extensive experiments show that KitWaSor achieves state-of-the-art(SOTA)performance on the two most relevant downstream tasks for kitchen waste sorting(i.e.image classification and object detection),demonstrating the effectiveness of the proposed KitWaSor.展开更多
Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for mo...Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for model training and the overshadowing of crucial features within sequence concatenation.The current work proposes a less data-consuming model incorporating a pre-trained gene sequence model and a mutual information inference operator.Our methodology utilizes gene alignment and deduplication algorithms to preprocess gene sequences,enhancing the model’s capacity to discern and focus on distinctions among input gene pairs.The model,i.e.,DNA Pretrained Cross-Immunity Protection Inference model(DPCIPI),outperforms state-of-theart(SOTA)models in predicting hemagglutination inhibition titer from influenza viral gene sequences only.Improvement in binary cross-immunity prediction is 1.58%in F1,2.34%in precision,1.57%in recall,and 1.57%in Accuracy.For multilevel cross-immunity improvements,the improvement is 2.12%in F1,3.50%in precision,2.19%in recall,and 2.19%in Accuracy.Our study showcases the potential of pre-trained gene models to improve predictions of antigenic variation and cross-immunity.With expanding gene data and advancements in pre-trained models,this approach promises significant impacts on vaccine development and public health.展开更多
Deep neural networks provide accurate results for most applications.However,they need a big dataset to train properly.Providing a big dataset is a significant challenge in most applications.Image augmentation refers t...Deep neural networks provide accurate results for most applications.However,they need a big dataset to train properly.Providing a big dataset is a significant challenge in most applications.Image augmentation refers to techniques that increase the amount of image data.Common operations for image augmentation include changes in illumination,rotation,contrast,size,viewing angle,and others.Recently,Generative Adversarial Networks(GANs)have been employed for image generation.However,like image augmentation methods,GAN approaches can only generate images that are similar to the original images.Therefore,they also cannot generate new classes of data.Texture images presentmore challenges than general images,and generating textures is more complex than creating other types of images.This study proposes a gradient-based deep neural network method that generates a new class of texture.It is possible to rapidly generate new classes of textures using different kernels from pre-trained deep networks.After generating new textures for each class,the number of textures increases through image augmentation.During this process,several techniques are proposed to automatically remove incomplete and similar textures that are created.The proposed method is faster than some well-known generative networks by around 4 to 10 times.In addition,the quality of the generated textures surpasses that of these networks.The proposed method can generate textures that surpass those of someGANs and parametric models in certain image qualitymetrics.It can provide a big texture dataset to train deep networks.A new big texture dataset is created artificially using the proposed method.This dataset is approximately 2 GB in size and comprises 30,000 textures,each 150×150 pixels in size,organized into 600 classes.It is uploaded to the Kaggle site and Google Drive.This dataset is called BigTex.Compared to other texture datasets,the proposed dataset is the largest and can serve as a comprehensive texture dataset for training more powerful deep neural networks and mitigating overfitting.展开更多
We analyze the suitability of existing pre-trained transformer-based language models(PLMs)for abstractive text summarization on German technical healthcare texts.The study focuses on the multilingual capabilities of t...We analyze the suitability of existing pre-trained transformer-based language models(PLMs)for abstractive text summarization on German technical healthcare texts.The study focuses on the multilingual capabilities of these models and their ability to perform the task of abstractive text summarization in the healthcare field.The research hypothesis was that large language models could perform high-quality abstractive text summarization on German technical healthcare texts,even if the model is not specifically trained in that language.Through experiments,the research questions explore the performance of transformer language models in dealing with complex syntax constructs,the difference in performance between models trained in English and German,and the impact of translating the source text to English before conducting the summarization.We conducted an evaluation of four PLMs(GPT-3,a translation-based approach also utilizing GPT-3,a German language Model,and a domain-specific bio-medical model approach).The evaluation considered the informativeness using 3 types of metrics based on Recall-Oriented Understudy for Gisting Evaluation(ROUGE)and the quality of results which is manually evaluated considering 5 aspects.The results show that text summarization models could be used in the German healthcare domain and that domain-independent language models achieved the best results.The study proves that text summarization models can simplify the search for pre-existing German knowledge in various domains.展开更多
汉滩病毒是一种单负链RNA病毒,在我国主要引起以发热、出血、急性肾功能损害和免疫功能紊乱为主要特征的肾综合征出血热(HFRS),临床治疗尚无特效治疗药物,主要依靠灭活疫苗进行预防,但其诱导机体产生病毒中和抗体滴度较低,诱导细胞免疫...汉滩病毒是一种单负链RNA病毒,在我国主要引起以发热、出血、急性肾功能损害和免疫功能紊乱为主要特征的肾综合征出血热(HFRS),临床治疗尚无特效治疗药物,主要依靠灭活疫苗进行预防,但其诱导机体产生病毒中和抗体滴度较低,诱导细胞免疫反应能力差。病毒样颗粒(virus like particles,VLP)具有病毒天然蛋白成分和构象,但不含病毒核酸,是理想的候选疫苗。将表达汉滩病毒包膜糖蛋白Gn和Gc的M片段与含有表达汉滩病毒核蛋白的S片段的载体在哺乳动物细胞中共表达,包装出汉滩病毒VLP,对包装出的VLP进行初步纯化和生物学特性的鉴定。展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.:U23A20530,82273858,and 82173746)the National Key Research and Development Programof China(Grant No.:2023YFF1204904)Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission,China).
文摘Activity cliffs(ACs)are generally defined as pairs of similar compounds that only differ by a minor structural modification but exhibit a large difference in their binding affinity for a given target.ACs offer crucial insights that aid medicinal chemists in optimizing molecular structures.Nonetheless,they also form a major source of prediction error in structure-activity relationship(SAR)models.To date,several studies have demonstrated that deep neural networks based on molecular images or graphs might need to be improved further in predicting the potency of ACs.In this paper,we integrated the triplet loss in face recognition with pre-training strategy to develop a prediction model ACtriplet,tailored for ACs.Through extensive comparison with multiple baseline models on 30 benchmark datasets,the results showed that ACtriplet was significantly better than those deep learning(DL)models without pretraining.In addition,we explored the effect of pre-training on data representation.Finally,the case study demonstrated that our model's interpretability module could explain the prediction results reasonably.In the dilemma that the amount of data could not be increased rapidly,this innovative framework would better make use of the existing data,which would propel the potential of DL in the early stage of drug discovery and optimization.
基金supported by the National Natural Science Foundation of China(U1435220)
文摘How to recognize targets with similar appearances from remote sensing images(RSIs) effectively and efficiently has become a big challenge. Recently, convolutional neural network(CNN) is preferred in the target classification due to the powerful feature representation ability and better performance. However,the training and testing of CNN mainly rely on single machine.Single machine has its natural limitation and bottleneck in processing RSIs due to limited hardware resources and huge time consuming. Besides, overfitting is a challenge for the CNN model due to the unbalance between RSIs data and the model structure.When a model is complex or the training data is relatively small,overfitting occurs and leads to a poor predictive performance. To address these problems, a distributed CNN architecture for RSIs target classification is proposed, which dramatically increases the training speed of CNN and system scalability. It improves the storage ability and processing efficiency of RSIs. Furthermore,Bayesian regularization approach is utilized in order to initialize the weights of the CNN extractor, which increases the robustness and flexibility of the CNN model. It helps prevent the overfitting and avoid the local optima caused by limited RSI training images or the inappropriate CNN structure. In addition, considering the efficiency of the Na¨?ve Bayes classifier, a distributed Na¨?ve Bayes classifier is designed to reduce the training cost. Compared with other algorithms, the proposed system and method perform the best and increase the recognition accuracy. The results show that the distributed system framework and the proposed algorithms are suitable for RSIs target classification tasks.
基金Supported by the National Natural Science Foundation of China (62006150)Songjiang District Science and Technology Research Project (19SJKJGG83)Shanghai Young Science and Technology Talents Sailing Program (19YF1418400)。
文摘Vision-Language-Navigation(VLN) task is a cross-modality task that combines natural language processing and computer vision. This task requires the agent to automatically move to the destination according to the natural language instruction and the observed surrounding visual information. To make the best decision, in every step during the navigation, the agent should pay more attention to understanding the objects, the object attributes, and the object relationships. But most current methods process all received textual and visual information equally. Therefore, this paper integrates more detailed semantic connections between visual and textual information through three pre-training tasks(object prediction, object attributes prediction, and object relationship prediction). The model will learn better fusion representation and alignment between these two types of information to improve the success rate(SR) and generalization. The experiments show that compared with the former baseline models, the SR on the unseen validation set(Val Unseen) increased by 7%, and the SR weighted by path length(SPL) increased by 7%;the SR on the test set(Test) increased 4%, SPL increased by 3%.
文摘Web-based training is growing quickly in popularit y for professionals in industrial organizations and large enterprises. The savings in cost and time are significant. The instructor-led trainings are bounded by time and place, not to mention the cost involved in traveling, accommodation and training venue. However, in the most online training courses, all trainees are given same training materials and teaching paradigms. The problem of differentia ting the trainees’ abilities is the main concern. We need a pre-training test t o identify and classify of the weaknesses and strengths of differentiate trainee s so as to devise an appropriate training programs for the trainees. Adaptation of a Web-based Computer adaptive Test (CAT) for the pre-training test make the web-based training more efficient. The advantages of CAT are self-pacing, eff iciency, time and cost saving, immediate scoring and feedback, accuracy and secu rity, etc (Rudner, 1998; UMN, 1999; Novell, 2000; Linacre, 2000; Windowsglore, 2 000). Moreover, Web-based CAT also gives greater flexibility and convenience. T his paper describes how this CAT tool is built, how it helps instructor identify the strengths and weaknesses of trainees, and how to assure quality on the CAT system.
文摘Handheld ultrasound devices are known for their portability and affordability,making them widely utilized in underdeveloped areas and community healthcare for rapid diagnosis and early screening.However,the image quality of handheld ultrasound devices is not always satisfactory due to the limited equipment size,which hinders accurate diagnoses by doctors.At the same time,paired ultrasound images are difficult to obtain from the clinic because imaging process is complicated.Therefore,we propose a modified cycle generative adversarial network(cycleGAN) for ultrasound image enhancement from multiple organs via unpaired pre-training.We introduce an ultrasound image pre-training method that does not require paired images,alleviating the requirement for large-scale paired datasets.We also propose an enhanced block with different structures in the pre-training and fine-tuning phases,which can help achieve the goals of different training phases.To improve the robustness of the model,we add Gaussian noise to the training images as data augmentation.Our approach is effective in obtaining the best quantitative evaluation results using a small number of parameters and less training costs to improve the quality of handheld ultrasound devices.
基金financially supported by the Natural Science Foundation of China(Grant No.42301492)the National Key R&D Program of China(Grant Nos.2022YFF0711600,2022YFF0801201,2022YFF0801200)+3 种基金the Major Special Project of Xinjiang(Grant No.2022A03009-3)the Open Fund of Key Laboratory of Urban Land Resources Monitoring and Simulation,Ministry of Natural Resources(Grant No.KF-2022-07014)the Opening Fund of the Key Laboratory of the Geological Survey and Evaluation of the Ministry of Education(Grant No.GLAB 2023ZR01)the Fundamental Research Funds for the Central Universities。
文摘As important geological data,a geological report contains rich expert and geological knowledge,but the challenge facing current research into geological knowledge extraction and mining is how to render accurate understanding of geological reports guided by domain knowledge.While generic named entity recognition models/tools can be utilized for the processing of geoscience reports/documents,their effectiveness is hampered by a dearth of domain-specific knowledge,which in turn leads to a pronounced decline in recognition accuracy.This study summarizes six types of typical geological entities,with reference to the ontological system of geological domains and builds a high quality corpus for the task of geological named entity recognition(GNER).In addition,Geo Wo BERT-adv BGP(Geological Word-base BERTadversarial training Bi-directional Long Short-Term Memory Global Pointer)is proposed to address the issues of ambiguity,diversity and nested entities for the geological entities.The model first uses the fine-tuned word granularitybased pre-training model Geo Wo BERT(Geological Word-base BERT)and combines the text features that are extracted using the Bi LSTM(Bi-directional Long Short-Term Memory),followed by an adversarial training algorithm to improve the robustness of the model and enhance its resistance to interference,the decoding finally being performed using a global association pointer algorithm.The experimental results show that the proposed model for the constructed dataset achieves high performance and is capable of mining the rich geological information.
基金National Key Research and Development Program of China,Grant/Award Number:2021YFC1910402。
文摘Intelligent sorting is an important prerequisite for the full quantitative consumption and harmless disposal of kitchen waste.The existing object detection method based on an ImageNet pre-trained model is an effective way of sorting.Owing to significant domain gaps between natural images and kitchen waste images,it is difficult to reflect the characteristics of diverse scales and dense distribution in kitchen waste based on an ImageNet pre-trained model,leading to poor generalisation.In this article,the authors propose the first pre-trained model for kitchen waste sorting called KitWaSor,which combines both contrastive learning(CL)and masked image modelling(MIM)through self-supervised learning(SSL).First,to address the issue of diverse scales,the authors propose a mixed masking strategy by introducing an incomplete masking branch based on the original random masking branch.It prevents the complete loss of small-scale objects while avoiding excessive leakage of large-scale object pixels.Second,to address the issue of dense distribution,the authors introduce semantic consistency constraints on the basis of the mixed masking strategy.That is,object semantic reasoning is performed through semantic consistency constraints to compensate for the lack of contextual information.To train KitWaSor,the authors construct the first million-level kitchen waste dataset across seasonal and regional distributions,named KWD-Million.Extensive experiments show that KitWaSor achieves state-of-the-art(SOTA)performance on the two most relevant downstream tasks for kitchen waste sorting(i.e.image classification and object detection),demonstrating the effectiveness of the proposed KitWaSor.
基金supported by the Bill & Melinda Gates Foundation and the Minderoo Foundation
文摘Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development.Traditional neural network methods,such as BiLSTM,could be ineffective due to the lack of lab data for model training and the overshadowing of crucial features within sequence concatenation.The current work proposes a less data-consuming model incorporating a pre-trained gene sequence model and a mutual information inference operator.Our methodology utilizes gene alignment and deduplication algorithms to preprocess gene sequences,enhancing the model’s capacity to discern and focus on distinctions among input gene pairs.The model,i.e.,DNA Pretrained Cross-Immunity Protection Inference model(DPCIPI),outperforms state-of-theart(SOTA)models in predicting hemagglutination inhibition titer from influenza viral gene sequences only.Improvement in binary cross-immunity prediction is 1.58%in F1,2.34%in precision,1.57%in recall,and 1.57%in Accuracy.For multilevel cross-immunity improvements,the improvement is 2.12%in F1,3.50%in precision,2.19%in recall,and 2.19%in Accuracy.Our study showcases the potential of pre-trained gene models to improve predictions of antigenic variation and cross-immunity.With expanding gene data and advancements in pre-trained models,this approach promises significant impacts on vaccine development and public health.
基金supported via funding from Prince Sattam bin Abdulaziz University(PSAU/2025/R/1446)Princess Nourah bint Abdulrahman University(PNURSP2025R300)Prince Sultan University.
文摘Deep neural networks provide accurate results for most applications.However,they need a big dataset to train properly.Providing a big dataset is a significant challenge in most applications.Image augmentation refers to techniques that increase the amount of image data.Common operations for image augmentation include changes in illumination,rotation,contrast,size,viewing angle,and others.Recently,Generative Adversarial Networks(GANs)have been employed for image generation.However,like image augmentation methods,GAN approaches can only generate images that are similar to the original images.Therefore,they also cannot generate new classes of data.Texture images presentmore challenges than general images,and generating textures is more complex than creating other types of images.This study proposes a gradient-based deep neural network method that generates a new class of texture.It is possible to rapidly generate new classes of textures using different kernels from pre-trained deep networks.After generating new textures for each class,the number of textures increases through image augmentation.During this process,several techniques are proposed to automatically remove incomplete and similar textures that are created.The proposed method is faster than some well-known generative networks by around 4 to 10 times.In addition,the quality of the generated textures surpasses that of these networks.The proposed method can generate textures that surpass those of someGANs and parametric models in certain image qualitymetrics.It can provide a big texture dataset to train deep networks.A new big texture dataset is created artificially using the proposed method.This dataset is approximately 2 GB in size and comprises 30,000 textures,each 150×150 pixels in size,organized into 600 classes.It is uploaded to the Kaggle site and Google Drive.This dataset is called BigTex.Compared to other texture datasets,the proposed dataset is the largest and can serve as a comprehensive texture dataset for training more powerful deep neural networks and mitigating overfitting.
文摘We analyze the suitability of existing pre-trained transformer-based language models(PLMs)for abstractive text summarization on German technical healthcare texts.The study focuses on the multilingual capabilities of these models and their ability to perform the task of abstractive text summarization in the healthcare field.The research hypothesis was that large language models could perform high-quality abstractive text summarization on German technical healthcare texts,even if the model is not specifically trained in that language.Through experiments,the research questions explore the performance of transformer language models in dealing with complex syntax constructs,the difference in performance between models trained in English and German,and the impact of translating the source text to English before conducting the summarization.We conducted an evaluation of four PLMs(GPT-3,a translation-based approach also utilizing GPT-3,a German language Model,and a domain-specific bio-medical model approach).The evaluation considered the informativeness using 3 types of metrics based on Recall-Oriented Understudy for Gisting Evaluation(ROUGE)and the quality of results which is manually evaluated considering 5 aspects.The results show that text summarization models could be used in the German healthcare domain and that domain-independent language models achieved the best results.The study proves that text summarization models can simplify the search for pre-existing German knowledge in various domains.
文摘汉滩病毒是一种单负链RNA病毒,在我国主要引起以发热、出血、急性肾功能损害和免疫功能紊乱为主要特征的肾综合征出血热(HFRS),临床治疗尚无特效治疗药物,主要依靠灭活疫苗进行预防,但其诱导机体产生病毒中和抗体滴度较低,诱导细胞免疫反应能力差。病毒样颗粒(virus like particles,VLP)具有病毒天然蛋白成分和构象,但不含病毒核酸,是理想的候选疫苗。将表达汉滩病毒包膜糖蛋白Gn和Gc的M片段与含有表达汉滩病毒核蛋白的S片段的载体在哺乳动物细胞中共表达,包装出汉滩病毒VLP,对包装出的VLP进行初步纯化和生物学特性的鉴定。
