After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the tim...After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.展开更多
Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at th...Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at the molecular,cellular,and neural circuit levels.Abnormal molecular signaling pathways or dysfunction of specific cell types can lead to epilepsy by disrupting the normal functioning of neural circuits.The continuous emergence of new technologies and the rapid advancement of existing ones have facilitated the discovery and comprehensive understanding of the neural circuit mechanisms underlying epilepsy.Therefore,this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies,including electroencephalography,magnetic resonance imaging,optogenetics,chemogenetics,deep brain stimulation,and brain-computer interfaces.Additionally,this review discusses these mechanisms from three perspectives:structural,synaptic,and transmitter circuits.The findings reveal that the neural circuit mechanisms of epilepsy encompass information transmission among different structures,interactions within the same structure,and the maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels.These findings offer new insights for investigating the pathophysiological mechanisms of epilepsy and enhancing its clinical diagnosis and treatment.展开更多
Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after inju...Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.展开更多
Regular expression matching is playing an important role in deep inspection. The rapid development of SDN and NFV makes the network more dynamic, bringing serious challenges to traditional deep inspection matching eng...Regular expression matching is playing an important role in deep inspection. The rapid development of SDN and NFV makes the network more dynamic, bringing serious challenges to traditional deep inspection matching engines. However, state-of-theart matching methods often require a significant amount of pre-processing time and hence are not suitable for this fast updating scenario. In this paper, a novel matching engine called BFA is proposed to achieve high-speed regular expression matching with fast pre-processing. Experiments demonstrate that BFA obtains 5 to 20 times more update abilities compared to existing regular expression matching methods, and scales well on multi-core platforms.展开更多
In order to carry out numerical simulation using geologic structural data obtained from Landmark(seismic interpretation system), underground geological structures are abstracted into mechanical models which can reflec...In order to carry out numerical simulation using geologic structural data obtained from Landmark(seismic interpretation system), underground geological structures are abstracted into mechanical models which can reflect actual situations and facilitate their computation and analyses.Given the importance of model building, further processing methods about traditional seismic interpretation results from Landmark should be studied and the processed result can then be directly used in numerical simulation computations.Through this data conversion procedure, Landmark and FLAC(the international general stress software) are seamlessly connected.Thus, the format conversion between the two systems and the pre-and post-processing in simulation computation is realized.A practical application indicates that this method has many advantages such as simple operation, high accuracy of the element subdivision and high speed, which may definitely satisfy the actual needs of floor grid cutting.展开更多
The Low Earth Orbit(LEO)remote sensing satellite mega-constellation has the characteristics of large quantity and various types which make it have unique superiority in the realization of concurrent multiple tasks.How...The Low Earth Orbit(LEO)remote sensing satellite mega-constellation has the characteristics of large quantity and various types which make it have unique superiority in the realization of concurrent multiple tasks.However,the complexity of resource allocation is increased because of the large number of tasks and satellites.Therefore,the primary problem of implementing concurrent multiple tasks via LEO mega-constellation is to pre-process tasks and observation re-sources.To address the challenge,we propose a pre-processing algorithm for the mega-constellation based on highly Dynamic Spatio-Temporal Grids(DSTG).In the first stage,this paper describes the management model of mega-constellation and the multiple tasks.Then,the coding method of DSTG is proposed,based on which the description of complex mega-constellation observation resources is realized.In the third part,the DSTG algorithm is used to realize the processing of concurrent multiple tasks at multiple levels,such as task space attribute,time attribute and grid task importance evaluation.Finally,the simulation result of the proposed method in the case of constellation has been given to verify the effectiveness of concurrent multi-task pre-processing based on DSTG.The autonomous processing process of task decomposition and task fusion and mapping to grids,and the convenient indexing process of time window are verified.展开更多
In order to meet the demands for high transmission rates and high service quality in broadband wireless communication systems, orthogonal frequency division multiplexing （OFDM） has been adopted in some standards. Ho...In order to meet the demands for high transmission rates and high service quality in broadband wireless communication systems, orthogonal frequency division multiplexing （OFDM） has been adopted in some standards. However, the inter-block interference （IBI） and inter-carrier interference （ICI） in an OFDM system affect the performance. To mitigate IBI and ICI, some pre-processing approaches have been proposed based on full channel state information （CSI）, which improved the system performance. A pre-processing filter based on partial CSI at the transmitter is designed and investigated. The filter coefficient is given by the optimization processing, the symbol error rate （SER） is tested, and the computation complexity of the proposed scheme is analyzed. Computer simulation results show that the proposed pre-processing filter can effectively mitigate IBI and ICI and the performance can be improved. Compared with pre-processing approaches at the transmitter based on full CSI, the proposed scheme has high spectral efficiency, limited CSI feedback and low computation complexity.展开更多
The Chang＇e-3 （CE-3） mission is China＇s first exploration mission on the surface of the Moon that uses a lander and a rover. Eight instruments that form the scientific payloads have the following objectives： （1...The Chang＇e-3 （CE-3） mission is China＇s first exploration mission on the surface of the Moon that uses a lander and a rover. Eight instruments that form the scientific payloads have the following objectives： （1） investigate the morphological features and geological structures at the landing site; （2） integrated in-situ analysis of minerals and chemical compositions; （3） integrated exploration of the structure of the lunar interior; （4） exploration of the lunar-terrestrial space environment, lunar sur- face environment and acquire Moon-based ultraviolet astronomical observations. The Ground Research and Application System （GRAS） is in charge of data acquisition and pre-processing, management of the payload in orbit, and managing the data products and their applications. The Data Pre-processing Subsystem （DPS） is a part of GRAS. The task of DPS is the pre-processing of raw data from the eight instruments that are part of CE-3, including channel processing, unpacking, package sorting, calibration and correction, identification of geographical location, calculation of probe azimuth angle, probe zenith angle, solar azimuth angle, and solar zenith angle and so on, and conducting quality checks. These processes produce Level 0, Level 1 and Level 2 data. The computing platform of this subsystem is comprised of a high-performance computing cluster, including a real-time subsystem used for processing Level 0 data and a post-time subsystem for generating Level 1 and Level 2 data. This paper de- scribes the CE-3 data pre-processing method, the data pre-processing subsystem, data classification, data validity and data products that are used for scientific studies.展开更多
High-resolution ice core records covering long time spans enable reconstruction of the past climatic and environmental conditions allowing the investigation of the earth system's evolution.Preprocessing of ice cor...High-resolution ice core records covering long time spans enable reconstruction of the past climatic and environmental conditions allowing the investigation of the earth system's evolution.Preprocessing of ice cores has direct impacts on the data quality control for further analysis since the conventional ice core processing is time-consuming,produces qualitative data,leads to ice mass loss,and leads to risks of potential secondary pollution.However,over the past several decades,preprocessing of ice cores has received less attention than the improvement of ice drilling,the analytical methodology of various indices,and the researches on the climatic and environmental significance of ice core records.Therefore,this papers reviews the development of the processing for ice cores including framework,design as well as materials,analyzes the technical advantages and disadvantages of the different systems.In the past,continuous flowanalysis(CFA)has been successfully applied to process the polar ice cores.However,it is not suitable for ice cores outside polar region because of high level of particles,the memory effect between samples,and the filtration before injection.Ice core processing is a subtle and professional operation due to the fragility of the nonmetallic materials and the random distribution of particles and air bubbles in ice cores,which aggravates uncertainty in the measurements.The future developments of CFA are discussed in preprocessing,memory effect,challenge for brittle ice,coupling with real-time analysis and optimization of CFA in the field.Furthermore,non-polluting cutters with many different configurations could be designed to cut and scrape in multiple directions and to separate inner and outer portions of the core.This system also needs to be coupled with streamlined operation of packaging,coding,and stacking that can be implemented at high resolution and rate,avoiding manual intervention.At the same time,information of the longitudinal sections could be scanned andidentified,and then classified to obtain quantitative data.In addition,irregular ice volume and weight can also be obtained accurately.These improvements are recorded automatically via user-friendly interfaces.These innovations may be applied to other paleomedias with similar features and needs.展开更多
Mathematical morphology is widely applicated in digital image procesing.Vari- ary morphology construction and algorithm being developed are used in deferent digital image processing.The basic idea of mathematical morp...Mathematical morphology is widely applicated in digital image procesing.Vari- ary morphology construction and algorithm being developed are used in deferent digital image processing.The basic idea of mathematical morphology is to use construction ele- ment measure image morphology for solving understand problem.The article presented advanced cellular neural network that forms mathematical morphological cellular neural network (MMCNN) equation to be suit for mathematical morphology filter.It gave the theo- ries of MMCNN dynamic extent and stable state.It is evidenced that arrived mathematical morphology filter through steady of dynamic process in definite condition.展开更多
There are a number of dirty data in observation data set derived from integrated ocean observing network system. Thus, the data must be carefully and reasonably processed before they are used for forecasting or analys...There are a number of dirty data in observation data set derived from integrated ocean observing network system. Thus, the data must be carefully and reasonably processed before they are used for forecasting or analysis. This paper proposes a data pre-processing model based on intelligent algorithms. Firstly, we introduce the integrated network platform of ocean observation. Next, the preprocessing model of data is presemed, and an imelligent cleaning model of data is proposed. Based on fuzzy clustering, the Kohonen clustering network is improved to fulfill the parallel calculation of fuzzy c-means clustering. The proposed dynamic algorithm can automatically f＇md the new clustering center with the updated sample data. The rapid and dynamic performance of the model makes it suitable for real time calculation, and the efficiency and accuracy of the model is proved by test results through observation data analysis.展开更多
A signal pre-processing method based on optimal variational mode decomposition(OVMD)is proposed to improve the efficiency and accuracy of local data filtering and analysis of edge nodes in distributed electromechanica...A signal pre-processing method based on optimal variational mode decomposition(OVMD)is proposed to improve the efficiency and accuracy of local data filtering and analysis of edge nodes in distributed electromechanical systems.Firstly,the singular points of original signals are eliminated effectively by using the first-order difference method.Then the OVMD method is applied for signal modal decomposition.Furthermore,correlation analysis is conducted to determine the degree of correlation between each mode and the original signal,so as to accurately separate the real operating signal from noise signal.On the basis of theoretical analysis and simulation,an edge node pre-processing system for distributed electromechanical system is designed.Finally,by virtue of the signal-to-noise ratio(SNR)and root-mean-square error(RMSE)indicators,the signal pre-processing effect is evaluated.The experimental results show that the OVMD-based edge node pre-processing system can extract signals with different characteristics and improve the SNR of reconstructed signals.Due to its high fidelity and reliability,this system can also provide data quality assurance for subsequent system health monitoring and fault diagnosis.展开更多
The solution of linear equation group can be applied to the oil exploration, the structure vibration analysis, the computational fluid dynamics, and other fields. When we make the in-depth analysis of some large or ve...The solution of linear equation group can be applied to the oil exploration, the structure vibration analysis, the computational fluid dynamics, and other fields. When we make the in-depth analysis of some large or very large complicated structures, we must use the parallel algorithm with the aid of high-performance computers to solve complex problems. This paper introduces the implementation process having the parallel with sparse linear equations from the perspective of sparse linear equation group.展开更多
Microarray data is inherently noisy due to the noise contaminated from various sources during the preparation of microarray slide and thus it greatly affects the accuracy of the gene expression. How to eliminate the e...Microarray data is inherently noisy due to the noise contaminated from various sources during the preparation of microarray slide and thus it greatly affects the accuracy of the gene expression. How to eliminate the effect of the noise constitutes a challenging problem in microarray analysis. Efficient denoising is often a necessary and the first step to be taken before the image data is analyzed to compensate for data corruption and for effective utilization for these data. Hence preprocessing of microarray image is an essential to eliminate the background noise in order to enhance the image quality and effective quantification. Existing denoising techniques based on transformed domain have been utilized for microarray noise reduction with their own limitations. The objective of this paper is to introduce novel preprocessing techniques such as optimized spatial resolution (OSR) and spatial domain filtering (SDF) for reduction of noise from microarray data and reduction of error during quantification process for estimating the microarray spots accurately to determine expression level of genes. Besides combined optimized spatial resolution and spatial filtering is proposed and found improved denoising of microarray data with effective quantification of spots. The proposed method has been validated in microarray images of gene expression profiles of Myeloid Leukemia using Stanford Microarray Database with various quality measures such as signal to noise ratio, peak signal to noise ratio, image fidelity, structural content, absolute average difference and correlation quality. It was observed by quantitative analysis that the proposed technique is more efficient for denoising the microarray image which enables to make it suitable for effective quantification.展开更多
Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experienci...Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.展开更多
Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse functi...Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis.To investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing chow.We found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons.These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses.Prolonged MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and connectivity.Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain.These findings may have implications for regenerative therapy in aging and neurodegeneration conditions.展开更多
The rise of large-scale artificial intelligence(AI)models,such as ChatGPT,Deep-Seek,and autonomous vehicle systems,has significantly advanced the boundaries of AI,enabling highly complex tasks in natural language proc...The rise of large-scale artificial intelligence(AI)models,such as ChatGPT,Deep-Seek,and autonomous vehicle systems,has significantly advanced the boundaries of AI,enabling highly complex tasks in natural language processing,image recognition,and real-time decisionmaking.However,these models demand immense computational power and are often centralized,relying on cloud-based architectures with inherent limitations in latency,privacy,and energy efficiency.To address these challenges and bring AI closer to real-world applications,such as wearable health monitoring,robotics,and immersive virtual environments,innovative hardware solutions are urgently needed.This work introduces a near-sensor edge computing(NSEC)system,built on a bilayer AlN/Si waveguide platform,to provide real-time,energy-efficient AI capabilities at the edge.Leveraging the electro-optic properties of AlN microring resonators for photonic feature extraction,coupled with Si-based thermo-optic Mach-Zehnder interferometers for neural network computations,the system represents a transformative approach to AI hardware design.Demonstrated through multimodal gesture and gait analysis,the NSEC system achieves high classification accuracies of 96.77%for gestures and 98.31%for gaits,ultra-low latency(<10 ns),and minimal energy consumption(<0.34 pJ).This groundbreaking system bridges the gap between AI models and real-world applications,enabling efficient,privacy-preserving AI solutions for healthcare,robotics,and next-generation human-machine interfaces,marking a pivotal advancement in edge computing and AI deployment.展开更多
In a pulsed plasma thruster,the voltage distribution between the electrodes is a key factor that influences the ionization process.However,few researchers have conducted in-depth studies of this phenomenon in the past...In a pulsed plasma thruster,the voltage distribution between the electrodes is a key factor that influences the ionization process.However,few researchers have conducted in-depth studies of this phenomenon in the past.Reported here are measurements of the voltage distribution between the plates of a parallel-plate pulsed plasma thruster under different discharge voltages,based on which the variations in the total circuit inductance and resistance as well as those between the plates are calculated.The results show that the time-averaged voltage across the plates accounts for 28.7%-50.4%of the capacitor voltage.As the capacitor initial voltage increases from 1250 V to 2000 V,the voltage across the plates rises,but its proportion relative to the capacitor voltage decreases.For every 250 V increase in the capacitor initial voltage,the average voltage proportion across the plates decreases by approximately 2%-3%.Additionally,the voltage proportion decreases gradually from the end near the propellant outward.The voltage distribution ratio between the plates is correlated with the proportions of the resistance and inductance between the plates relative to the total circuit.展开更多
In this paper,we propose an RLC equivalent circuit model theory which can accurately predict the spectral response and resonance characteristics of metamaterial absorption structures,extend its design,and characterize...In this paper,we propose an RLC equivalent circuit model theory which can accurately predict the spectral response and resonance characteristics of metamaterial absorption structures,extend its design,and characterize the parameters of the model in detail.By employing this model,we conducted computations to characterize the response wavelength and bandwidth of variously sized metamaterial absorbers.A comparative analysis with Finite Difference Time Domain(FDTD)simulations demonstrated a remarkable level of consistency in the results.The designed absorbers were fabricated using micro-nano fabrication processes,and were experimentally tested to demonstrate absorption rates exceeding 90%at a wavelength of 9.28μm.The predicted results are then compared with test results.The comparison reveals good consistency in two aspects of the resonance responses,thereby confirming the rationality and accuracy of this model.展开更多
The advent of Grover’s algorithm presents a significant threat to classical block cipher security,spurring research into post-quantum secure cipher design.This study engineers quantum circuit implementations for thre...The advent of Grover’s algorithm presents a significant threat to classical block cipher security,spurring research into post-quantum secure cipher design.This study engineers quantum circuit implementations for three versions of the Ballet family block ciphers.The Ballet‑p/k includes a modular-addition operation uncommon in lightweight block ciphers.Quantum ripple-carry adder is implemented for both“32+32”and“64+64”scale to support this operation.Subsequently,qubits,quantum gates count,and quantum circuit depth of three versions of Ballet algorithm are systematically evaluated under quantum computing model,and key recovery attack circuits are constructed based on Grover’s algorithm against each version.The comprehensive analysis shows:Ballet-128/128 fails to NIST Level 1 security,while when the resource accounting is restricted to the Clifford gates and T gates set for the Ballet-128/256 and Ballet-256/256 quantum circuits,the design attains Level 3.展开更多
基金supported by the National Key Research and Development Program of China,No.2023YFC3603705(to DX)the National Natural Science Foundation of China,No.82302866(to YZ).
文摘After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.
基金supported by Basic Research Programs of Science and Technology Commission Foundation of Shanxi Province,No.20210302123486(to WJ).
文摘Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at the molecular,cellular,and neural circuit levels.Abnormal molecular signaling pathways or dysfunction of specific cell types can lead to epilepsy by disrupting the normal functioning of neural circuits.The continuous emergence of new technologies and the rapid advancement of existing ones have facilitated the discovery and comprehensive understanding of the neural circuit mechanisms underlying epilepsy.Therefore,this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies,including electroencephalography,magnetic resonance imaging,optogenetics,chemogenetics,deep brain stimulation,and brain-computer interfaces.Additionally,this review discusses these mechanisms from three perspectives:structural,synaptic,and transmitter circuits.The findings reveal that the neural circuit mechanisms of epilepsy encompass information transmission among different structures,interactions within the same structure,and the maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels.These findings offer new insights for investigating the pathophysiological mechanisms of epilepsy and enhancing its clinical diagnosis and treatment.
文摘Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.
基金supported by the National Key Technology R&D Program of China under Grant No. 2015BAK34B00the National Key Research and Development Program of China under Grant No. 2016YFB1000102
文摘Regular expression matching is playing an important role in deep inspection. The rapid development of SDN and NFV makes the network more dynamic, bringing serious challenges to traditional deep inspection matching engines. However, state-of-theart matching methods often require a significant amount of pre-processing time and hence are not suitable for this fast updating scenario. In this paper, a novel matching engine called BFA is proposed to achieve high-speed regular expression matching with fast pre-processing. Experiments demonstrate that BFA obtains 5 to 20 times more update abilities compared to existing regular expression matching methods, and scales well on multi-core platforms.
基金Projects 50221402, 50490271 and 50025413 supported by the National Natural Science Foundation of Chinathe National Basic Research Program of China (2009CB219603, 2009 CB724601, 2006CB202209 and 2005CB221500)+1 种基金the Key Project of the Ministry of Education (306002)the Program for Changjiang Scholars and Innovative Research Teams in Universities of MOE (IRT0408)
文摘In order to carry out numerical simulation using geologic structural data obtained from Landmark(seismic interpretation system), underground geological structures are abstracted into mechanical models which can reflect actual situations and facilitate their computation and analyses.Given the importance of model building, further processing methods about traditional seismic interpretation results from Landmark should be studied and the processed result can then be directly used in numerical simulation computations.Through this data conversion procedure, Landmark and FLAC(the international general stress software) are seamlessly connected.Thus, the format conversion between the two systems and the pre-and post-processing in simulation computation is realized.A practical application indicates that this method has many advantages such as simple operation, high accuracy of the element subdivision and high speed, which may definitely satisfy the actual needs of floor grid cutting.
基金supported by the National Natural Science Foundation of China(Nos.62003115 and 11972130)the Shenzhen Science and Technology Program,China(JCYJ20220818102207015)the Heilongjiang Touyan Team Program,China。
文摘The Low Earth Orbit(LEO)remote sensing satellite mega-constellation has the characteristics of large quantity and various types which make it have unique superiority in the realization of concurrent multiple tasks.However,the complexity of resource allocation is increased because of the large number of tasks and satellites.Therefore,the primary problem of implementing concurrent multiple tasks via LEO mega-constellation is to pre-process tasks and observation re-sources.To address the challenge,we propose a pre-processing algorithm for the mega-constellation based on highly Dynamic Spatio-Temporal Grids(DSTG).In the first stage,this paper describes the management model of mega-constellation and the multiple tasks.Then,the coding method of DSTG is proposed,based on which the description of complex mega-constellation observation resources is realized.In the third part,the DSTG algorithm is used to realize the processing of concurrent multiple tasks at multiple levels,such as task space attribute,time attribute and grid task importance evaluation.Finally,the simulation result of the proposed method in the case of constellation has been given to verify the effectiveness of concurrent multi-task pre-processing based on DSTG.The autonomous processing process of task decomposition and task fusion and mapping to grids,and the convenient indexing process of time window are verified.
基金supported by the National Natural Science Foundation of China(60902045)the National High-Tech Research and Developmeent Program of China(863 Program)(2011AA01A105)
文摘In order to meet the demands for high transmission rates and high service quality in broadband wireless communication systems, orthogonal frequency division multiplexing （OFDM） has been adopted in some standards. However, the inter-block interference （IBI） and inter-carrier interference （ICI） in an OFDM system affect the performance. To mitigate IBI and ICI, some pre-processing approaches have been proposed based on full channel state information （CSI）, which improved the system performance. A pre-processing filter based on partial CSI at the transmitter is designed and investigated. The filter coefficient is given by the optimization processing, the symbol error rate （SER） is tested, and the computation complexity of the proposed scheme is analyzed. Computer simulation results show that the proposed pre-processing filter can effectively mitigate IBI and ICI and the performance can be improved. Compared with pre-processing approaches at the transmitter based on full CSI, the proposed scheme has high spectral efficiency, limited CSI feedback and low computation complexity.
文摘The Chang＇e-3 （CE-3） mission is China＇s first exploration mission on the surface of the Moon that uses a lander and a rover. Eight instruments that form the scientific payloads have the following objectives： （1） investigate the morphological features and geological structures at the landing site; （2） integrated in-situ analysis of minerals and chemical compositions; （3） integrated exploration of the structure of the lunar interior; （4） exploration of the lunar-terrestrial space environment, lunar sur- face environment and acquire Moon-based ultraviolet astronomical observations. The Ground Research and Application System （GRAS） is in charge of data acquisition and pre-processing, management of the payload in orbit, and managing the data products and their applications. The Data Pre-processing Subsystem （DPS） is a part of GRAS. The task of DPS is the pre-processing of raw data from the eight instruments that are part of CE-3, including channel processing, unpacking, package sorting, calibration and correction, identification of geographical location, calculation of probe azimuth angle, probe zenith angle, solar azimuth angle, and solar zenith angle and so on, and conducting quality checks. These processes produce Level 0, Level 1 and Level 2 data. The computing platform of this subsystem is comprised of a high-performance computing cluster, including a real-time subsystem used for processing Level 0 data and a post-time subsystem for generating Level 1 and Level 2 data. This paper de- scribes the CE-3 data pre-processing method, the data pre-processing subsystem, data classification, data validity and data products that are used for scientific studies.
基金supported by the National Natural Science Foundation of China(Grant No.41630754)the State Key Laboratory of Cryospheric Science(SKLCS-ZZ-2017)CAS Key Technology Talent Program and Open Foundation of State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering(2017490711)
文摘High-resolution ice core records covering long time spans enable reconstruction of the past climatic and environmental conditions allowing the investigation of the earth system's evolution.Preprocessing of ice cores has direct impacts on the data quality control for further analysis since the conventional ice core processing is time-consuming,produces qualitative data,leads to ice mass loss,and leads to risks of potential secondary pollution.However,over the past several decades,preprocessing of ice cores has received less attention than the improvement of ice drilling,the analytical methodology of various indices,and the researches on the climatic and environmental significance of ice core records.Therefore,this papers reviews the development of the processing for ice cores including framework,design as well as materials,analyzes the technical advantages and disadvantages of the different systems.In the past,continuous flowanalysis(CFA)has been successfully applied to process the polar ice cores.However,it is not suitable for ice cores outside polar region because of high level of particles,the memory effect between samples,and the filtration before injection.Ice core processing is a subtle and professional operation due to the fragility of the nonmetallic materials and the random distribution of particles and air bubbles in ice cores,which aggravates uncertainty in the measurements.The future developments of CFA are discussed in preprocessing,memory effect,challenge for brittle ice,coupling with real-time analysis and optimization of CFA in the field.Furthermore,non-polluting cutters with many different configurations could be designed to cut and scrape in multiple directions and to separate inner and outer portions of the core.This system also needs to be coupled with streamlined operation of packaging,coding,and stacking that can be implemented at high resolution and rate,avoiding manual intervention.At the same time,information of the longitudinal sections could be scanned andidentified,and then classified to obtain quantitative data.In addition,irregular ice volume and weight can also be obtained accurately.These improvements are recorded automatically via user-friendly interfaces.These innovations may be applied to other paleomedias with similar features and needs.
文摘Mathematical morphology is widely applicated in digital image procesing.Vari- ary morphology construction and algorithm being developed are used in deferent digital image processing.The basic idea of mathematical morphology is to use construction ele- ment measure image morphology for solving understand problem.The article presented advanced cellular neural network that forms mathematical morphological cellular neural network (MMCNN) equation to be suit for mathematical morphology filter.It gave the theo- ries of MMCNN dynamic extent and stable state.It is evidenced that arrived mathematical morphology filter through steady of dynamic process in definite condition.
基金Key Science and Technology Project of the Shanghai Committee of Science and Technology, China (No.06dz1200921)Major Basic Research Project of the Shanghai Committee of Science and Technology(No.08JC1400100)+1 种基金Shanghai Talent Developing Foundation, China(No.001)Specialized Foundation for Excellent Talent of Shanghai,China
文摘There are a number of dirty data in observation data set derived from integrated ocean observing network system. Thus, the data must be carefully and reasonably processed before they are used for forecasting or analysis. This paper proposes a data pre-processing model based on intelligent algorithms. Firstly, we introduce the integrated network platform of ocean observation. Next, the preprocessing model of data is presemed, and an imelligent cleaning model of data is proposed. Based on fuzzy clustering, the Kohonen clustering network is improved to fulfill the parallel calculation of fuzzy c-means clustering. The proposed dynamic algorithm can automatically f＇md the new clustering center with the updated sample data. The rapid and dynamic performance of the model makes it suitable for real time calculation, and the efficiency and accuracy of the model is proved by test results through observation data analysis.
基金National Natural Science Foundation of China(No.61903291)Industrialization Project of Shaanxi Provincial Department of Education(No.18JC018)。
文摘A signal pre-processing method based on optimal variational mode decomposition(OVMD)is proposed to improve the efficiency and accuracy of local data filtering and analysis of edge nodes in distributed electromechanical systems.Firstly,the singular points of original signals are eliminated effectively by using the first-order difference method.Then the OVMD method is applied for signal modal decomposition.Furthermore,correlation analysis is conducted to determine the degree of correlation between each mode and the original signal,so as to accurately separate the real operating signal from noise signal.On the basis of theoretical analysis and simulation,an edge node pre-processing system for distributed electromechanical system is designed.Finally,by virtue of the signal-to-noise ratio(SNR)and root-mean-square error(RMSE)indicators,the signal pre-processing effect is evaluated.The experimental results show that the OVMD-based edge node pre-processing system can extract signals with different characteristics and improve the SNR of reconstructed signals.Due to its high fidelity and reliability,this system can also provide data quality assurance for subsequent system health monitoring and fault diagnosis.
文摘The solution of linear equation group can be applied to the oil exploration, the structure vibration analysis, the computational fluid dynamics, and other fields. When we make the in-depth analysis of some large or very large complicated structures, we must use the parallel algorithm with the aid of high-performance computers to solve complex problems. This paper introduces the implementation process having the parallel with sparse linear equations from the perspective of sparse linear equation group.
文摘Microarray data is inherently noisy due to the noise contaminated from various sources during the preparation of microarray slide and thus it greatly affects the accuracy of the gene expression. How to eliminate the effect of the noise constitutes a challenging problem in microarray analysis. Efficient denoising is often a necessary and the first step to be taken before the image data is analyzed to compensate for data corruption and for effective utilization for these data. Hence preprocessing of microarray image is an essential to eliminate the background noise in order to enhance the image quality and effective quantification. Existing denoising techniques based on transformed domain have been utilized for microarray noise reduction with their own limitations. The objective of this paper is to introduce novel preprocessing techniques such as optimized spatial resolution (OSR) and spatial domain filtering (SDF) for reduction of noise from microarray data and reduction of error during quantification process for estimating the microarray spots accurately to determine expression level of genes. Besides combined optimized spatial resolution and spatial filtering is proposed and found improved denoising of microarray data with effective quantification of spots. The proposed method has been validated in microarray images of gene expression profiles of Myeloid Leukemia using Stanford Microarray Database with various quality measures such as signal to noise ratio, peak signal to noise ratio, image fidelity, structural content, absolute average difference and correlation quality. It was observed by quantitative analysis that the proposed technique is more efficient for denoising the microarray image which enables to make it suitable for effective quantification.
基金supported by the Brain&Behavior Research Foundation(30233).
文摘Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.
基金supported by NIH/NIMH grant R01MH111619(to SQ),R21AG078700(to SQ)Institute of Mental Health Research(IMHR,Level 1 funding,to SQ and DF)institution startup fund from The University of Arizona(to SQ)。
文摘Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis.To investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing chow.We found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons.These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses.Prolonged MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and connectivity.Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain.These findings may have implications for regenerative therapy in aging and neurodegeneration conditions.
基金the National Research Foundation(NRF)Singapore mid-sized center grant(NRF-MSG-2023-0002)FrontierCRP grant(NRF-F-CRP-2024-0006)+2 种基金A*STAR Singapore MTC RIE2025 project(M24W1NS005)IAF-PP project(M23M5a0069)Ministry of Education(MOE)Singapore Tier 2 project(MOE-T2EP50220-0014).
文摘The rise of large-scale artificial intelligence(AI)models,such as ChatGPT,Deep-Seek,and autonomous vehicle systems,has significantly advanced the boundaries of AI,enabling highly complex tasks in natural language processing,image recognition,and real-time decisionmaking.However,these models demand immense computational power and are often centralized,relying on cloud-based architectures with inherent limitations in latency,privacy,and energy efficiency.To address these challenges and bring AI closer to real-world applications,such as wearable health monitoring,robotics,and immersive virtual environments,innovative hardware solutions are urgently needed.This work introduces a near-sensor edge computing(NSEC)system,built on a bilayer AlN/Si waveguide platform,to provide real-time,energy-efficient AI capabilities at the edge.Leveraging the electro-optic properties of AlN microring resonators for photonic feature extraction,coupled with Si-based thermo-optic Mach-Zehnder interferometers for neural network computations,the system represents a transformative approach to AI hardware design.Demonstrated through multimodal gesture and gait analysis,the NSEC system achieves high classification accuracies of 96.77%for gestures and 98.31%for gaits,ultra-low latency(<10 ns),and minimal energy consumption(<0.34 pJ).This groundbreaking system bridges the gap between AI models and real-world applications,enabling efficient,privacy-preserving AI solutions for healthcare,robotics,and next-generation human-machine interfaces,marking a pivotal advancement in edge computing and AI deployment.
基金supported by the Beijing Natural Science Foundation(No.QY24166).
文摘In a pulsed plasma thruster,the voltage distribution between the electrodes is a key factor that influences the ionization process.However,few researchers have conducted in-depth studies of this phenomenon in the past.Reported here are measurements of the voltage distribution between the plates of a parallel-plate pulsed plasma thruster under different discharge voltages,based on which the variations in the total circuit inductance and resistance as well as those between the plates are calculated.The results show that the time-averaged voltage across the plates accounts for 28.7%-50.4%of the capacitor voltage.As the capacitor initial voltage increases from 1250 V to 2000 V,the voltage across the plates rises,but its proportion relative to the capacitor voltage decreases.For every 250 V increase in the capacitor initial voltage,the average voltage proportion across the plates decreases by approximately 2%-3%.Additionally,the voltage proportion decreases gradually from the end near the propellant outward.The voltage distribution ratio between the plates is correlated with the proportions of the resistance and inductance between the plates relative to the total circuit.
基金Supported by the National Natural Science Foundation of China(62174092)the Open Fund of State Key Laboratory of Infrared Physics(SITP-NLIST-ZD-2023-04)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0580000)。
文摘In this paper,we propose an RLC equivalent circuit model theory which can accurately predict the spectral response and resonance characteristics of metamaterial absorption structures,extend its design,and characterize the parameters of the model in detail.By employing this model,we conducted computations to characterize the response wavelength and bandwidth of variously sized metamaterial absorbers.A comparative analysis with Finite Difference Time Domain(FDTD)simulations demonstrated a remarkable level of consistency in the results.The designed absorbers were fabricated using micro-nano fabrication processes,and were experimentally tested to demonstrate absorption rates exceeding 90%at a wavelength of 9.28μm.The predicted results are then compared with test results.The comparison reveals good consistency in two aspects of the resonance responses,thereby confirming the rationality and accuracy of this model.
基金State Key Lab of Processors,Institute of Computing Technology,Chinese Academy of Sciences(CLQ202516)the Fundamental Research Funds for the Central Universities of China(3282025047,3282024051,3282024009)。
文摘The advent of Grover’s algorithm presents a significant threat to classical block cipher security,spurring research into post-quantum secure cipher design.This study engineers quantum circuit implementations for three versions of the Ballet family block ciphers.The Ballet‑p/k includes a modular-addition operation uncommon in lightweight block ciphers.Quantum ripple-carry adder is implemented for both“32+32”and“64+64”scale to support this operation.Subsequently,qubits,quantum gates count,and quantum circuit depth of three versions of Ballet algorithm are systematically evaluated under quantum computing model,and key recovery attack circuits are constructed based on Grover’s algorithm against each version.The comprehensive analysis shows:Ballet-128/128 fails to NIST Level 1 security,while when the resource accounting is restricted to the Clifford gates and T gates set for the Ballet-128/256 and Ballet-256/256 quantum circuits,the design attains Level 3.
