In high-speed multiuser Time Reversal(TR)downlink systems,the transmission rate is degraded due to the presence of severe inter-user and inter-symbol interference.Moreover,maximizing the weighted sum rate in such syst...In high-speed multiuser Time Reversal(TR)downlink systems,the transmission rate is degraded due to the presence of severe inter-user and inter-symbol interference.Moreover,maximizing the weighted sum rate in such systems is a critical objective,since the weighting factors represent the priority of different users in different applications.However,it faces significant challenges as it is an NP-hard and non-convex problem.In order to suppress these interferences and maximize the weighted sum rate,in this paper we present a novel approach for the joint design of the pre-filters.The proposed method applies successive convex approximation to transform the original problem into a Second-Order Cone Programming(SOCP)problem.Then,a low-complexity iterative algorithm is provided to effectively solve the resulting SOCP problem.According to the simulation results,the proposed method reaches a local optimum within a few iterations and demonstrates superior performance in terms of weighted sum rate compared to the current algorithm.展开更多
To support the rapid automatic services composition and fulfill multi-quality of service （multi- QoS） demand, we propose a novel approach to realize services composition automatically by a prefihering process. Aimed...To support the rapid automatic services composition and fulfill multi-quality of service （multi- QoS） demand, we propose a novel approach to realize services composition automatically by a prefihering process. Aimed at a set of web services with similar functionality and different quality of service （QoS） , a semantic services chain is given and a corresponding constructing algorithm is proposed to construct the data structure. A pre-filtering process is put forward to find whether a composition service before planning exists. It can avoid aborted planning. An optimal planning algorithm is proposed which can choose the most suitable service from a lot of similar candidate services based on semantic service chains and multi-QoS values. The algorithms can improve the correctness and automation performances of automated semantic web services composition. As an example, a concrete composite process is analyzed. Experimental results show the validity of the composite process.展开更多
Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong disability.Currently,there are no FDA-approved therapies a...Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong disability.Currently,there are no FDA-approved therapies available to promote nerve regeneration.Tacrolimus accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve surgery.The authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug exposure.Tacrolimus is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 days.Size and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible byproducts.Tacrolimus released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic delivery.Given its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.展开更多
Composites derived from metal-organic frameworks(MOFs)show promise as catalysts for the photocat-alytic reduction of CO_(2).However,their potential is hindered by constraints such as limited light absorp-tion and slug...Composites derived from metal-organic frameworks(MOFs)show promise as catalysts for the photocat-alytic reduction of CO_(2).However,their potential is hindered by constraints such as limited light absorp-tion and sluggish electron transfer and separation,impacting the overall efficiency of the photocatalytic process.In this study,TiO_(2)nanocrystals,modified with Ptx+,underwent laser etching were encapsulated within the traditional MOF-ZIF-8 framework.This enhanced the adsorption capabilities for CO_(2)reactants and solar light,while also facilitating directed electron transfer and the separation of photogenerated charges.The finely-tuned catalyst demonstrates impressive CH_(4) selectivity at 9.5%,with yields of 250.24μmol g^(-1)h^(-1)for CO and 25.43μmol g^(-1)h^(-1)for CH_(4),utilizing water as a hole trap and H^(+)source.This study demonstrates the viability of achieving characteristics related to the separation of photogen-erated charges in TiO_(2)nanocrystals through laser etching and MOF composite catalysts.It offers novel perspectives for designing MOF-based catalysts with enhanced performance in artificial photosynthesis.展开更多
WRAP(Water Rights Analysis Package)水权分析模型是基于水资源优先分配制度来模拟和预测一个或多个流域内水资源使用及管理的模型。作者首次将WRAP水权分析模型应用于北京通州区,以1956～2007年通州区相关资料作为模型的计算数据,模...WRAP(Water Rights Analysis Package)水权分析模型是基于水资源优先分配制度来模拟和预测一个或多个流域内水资源使用及管理的模型。作者首次将WRAP水权分析模型应用于北京通州区,以1956～2007年通州区相关资料作为模型的计算数据,模拟与计算结果表明:通州地区的天然年径流总体趋势基本保持不变,调度径流呈微弱增长趋势,两者的年际变差均逐渐剧烈;历年的径流消耗量总体趋势亦基本不变,但回归流呈逐渐增长趋势;研究区内多年平均水量保证率为59.9%,工业用水、城镇生活用水和农村生活用水呈上升趋势,而农业用水量总体呈下降趋势。展开更多
目的:探讨抑制p53的反义转录本WRAP53α基因表达对顺铂(cisplatin,CDDP)诱导人骨肉瘤U-2OS细胞凋亡的影响。方法:不同浓度的CDDP处理U-2OS细胞后,MTT法检测细胞的增殖率;不同浓度CDDP处理36 h和10μmol/L CDDP处理不同时间以及si WRAP5...目的:探讨抑制p53的反义转录本WRAP53α基因表达对顺铂(cisplatin,CDDP)诱导人骨肉瘤U-2OS细胞凋亡的影响。方法:不同浓度的CDDP处理U-2OS细胞后,MTT法检测细胞的增殖率;不同浓度CDDP处理36 h和10μmol/L CDDP处理不同时间以及si WRAP53转染后,实时荧光定量PCR和蛋白质印迹法检测U-2OS细胞中WARAP53α和p53 m RNA及p53蛋白的表达水平;FCM法检测CDDP单独处理及si WRAP53转染后联合CDDP处理组U-2OS细胞的凋亡率。结果:CDDP处理后,U-2OS细胞的增殖率低于未处理的对照组(P<0.05),且呈浓度依赖性。CDDP处理后,U-2OS细胞中WRAP53αm RNA的表达水平明显高于未处理的空白对照组(P<0.05),且呈浓度和时间依赖性;p53 m RNA及p53蛋白的表达水平高于空白对照组(P<0.05)。si WRAP53转染后,WRAP53α和p53 m RNA及p53蛋白的表达水平低于空白对照组(P<0.05)。CDDP单独给药组U-2OS细胞凋亡率高于si WRAP53α转染联合CDDP处理组(P<0.05),2组细胞的凋亡率均高于空白对照组(P<0.05)。结论:CDDP可抑制U-2OS细胞的增殖,诱导WRAP53α和p53 m RNA及p53蛋白的表达;干扰WRAP53α基因的表达可下调p53的表达水平,并逆转CDDP诱导的细胞凋亡。展开更多
A web service wrapping approach for command line programs,which are commonly used in scientific computing,is proposed.First,software architecture for a basic web service wrapper implementation is given and the functio...A web service wrapping approach for command line programs,which are commonly used in scientific computing,is proposed.First,software architecture for a basic web service wrapper implementation is given and the functions of the main components are explained.Then after a comprehensive analysis of data transmission and a job life cycle model,a novel proactive file transmission and job management mechanism is devised to enhance the software architecture,and the command line programs are wrapped into web services in such a way that they can efficiently transmit files,supply instant status feedback and automatically manage the jobs.Experiments show that the proposed approach achieves higher performance with less memory usage compared to the related work, and the usability is also improved.This work has already been put into use in a production system of scientific computing and the data processing efficiency of the system is greatly improved.展开更多
基金partially supported by the following funding sources:The National Natural Science Foundation of China(No.61771084)the Chongqing Graduate Scientific Research Innovation Project(No.CYB21200)。
文摘In high-speed multiuser Time Reversal(TR)downlink systems,the transmission rate is degraded due to the presence of severe inter-user and inter-symbol interference.Moreover,maximizing the weighted sum rate in such systems is a critical objective,since the weighting factors represent the priority of different users in different applications.However,it faces significant challenges as it is an NP-hard and non-convex problem.In order to suppress these interferences and maximize the weighted sum rate,in this paper we present a novel approach for the joint design of the pre-filters.The proposed method applies successive convex approximation to transform the original problem into a Second-Order Cone Programming(SOCP)problem.Then,a low-complexity iterative algorithm is provided to effectively solve the resulting SOCP problem.According to the simulation results,the proposed method reaches a local optimum within a few iterations and demonstrates superior performance in terms of weighted sum rate compared to the current algorithm.
基金Supported by the National Natural Science Foundation of China （No. 61201252, 60775037） , Humanities and Social Sciences Foundation of the Ministry of Education （No. 10YJC870046 ）, Natural Science Research Key Project of Anhui Provincial Higher Education （No. KJ2011 A128） , Soft Science Project of Anhui Province （ No. 11020503009）.
文摘To support the rapid automatic services composition and fulfill multi-quality of service （multi- QoS） demand, we propose a novel approach to realize services composition automatically by a prefihering process. Aimed at a set of web services with similar functionality and different quality of service （QoS） , a semantic services chain is given and a corresponding constructing algorithm is proposed to construct the data structure. A pre-filtering process is put forward to find whether a composition service before planning exists. It can avoid aborted planning. An optimal planning algorithm is proposed which can choose the most suitable service from a lot of similar candidate services based on semantic service chains and multi-QoS values. The algorithms can improve the correctness and automation performances of automated semantic web services composition. As an example, a concrete composite process is analyzed. Experimental results show the validity of the composite process.
基金supported by the German Research Foundation(DA 2255/1-1to SCD)+4 种基金a SickKids Research Training Competition(RESTRACOMP)Graduate Scholarship(to KJWS)an Ontario Graduate Scholarship(to KJWS)a grant from Natural Sciences and Engineering Research Council of Canada(NSERC)(to KJWS)a Kickstarter grant from the Institute of Biomedical Engineering(BME)at the University of Toronto(to KJWS)the Abe Frank Fund from the Riley’s Children Foundation(GHB)。
文摘Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong disability.Currently,there are no FDA-approved therapies available to promote nerve regeneration.Tacrolimus accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve surgery.The authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug exposure.Tacrolimus is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 days.Size and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible byproducts.Tacrolimus released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic delivery.Given its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.
文摘Composites derived from metal-organic frameworks(MOFs)show promise as catalysts for the photocat-alytic reduction of CO_(2).However,their potential is hindered by constraints such as limited light absorp-tion and sluggish electron transfer and separation,impacting the overall efficiency of the photocatalytic process.In this study,TiO_(2)nanocrystals,modified with Ptx+,underwent laser etching were encapsulated within the traditional MOF-ZIF-8 framework.This enhanced the adsorption capabilities for CO_(2)reactants and solar light,while also facilitating directed electron transfer and the separation of photogenerated charges.The finely-tuned catalyst demonstrates impressive CH_(4) selectivity at 9.5%,with yields of 250.24μmol g^(-1)h^(-1)for CO and 25.43μmol g^(-1)h^(-1)for CH_(4),utilizing water as a hole trap and H^(+)source.This study demonstrates the viability of achieving characteristics related to the separation of photogen-erated charges in TiO_(2)nanocrystals through laser etching and MOF composite catalysts.It offers novel perspectives for designing MOF-based catalysts with enhanced performance in artificial photosynthesis.
文摘WRAP(Water Rights Analysis Package)水权分析模型是基于水资源优先分配制度来模拟和预测一个或多个流域内水资源使用及管理的模型。作者首次将WRAP水权分析模型应用于北京通州区,以1956～2007年通州区相关资料作为模型的计算数据,模拟与计算结果表明:通州地区的天然年径流总体趋势基本保持不变,调度径流呈微弱增长趋势,两者的年际变差均逐渐剧烈;历年的径流消耗量总体趋势亦基本不变,但回归流呈逐渐增长趋势;研究区内多年平均水量保证率为59.9%,工业用水、城镇生活用水和农村生活用水呈上升趋势,而农业用水量总体呈下降趋势。
文摘目的:探讨抑制p53的反义转录本WRAP53α基因表达对顺铂(cisplatin,CDDP)诱导人骨肉瘤U-2OS细胞凋亡的影响。方法:不同浓度的CDDP处理U-2OS细胞后,MTT法检测细胞的增殖率;不同浓度CDDP处理36 h和10μmol/L CDDP处理不同时间以及si WRAP53转染后,实时荧光定量PCR和蛋白质印迹法检测U-2OS细胞中WARAP53α和p53 m RNA及p53蛋白的表达水平;FCM法检测CDDP单独处理及si WRAP53转染后联合CDDP处理组U-2OS细胞的凋亡率。结果:CDDP处理后,U-2OS细胞的增殖率低于未处理的对照组(P<0.05),且呈浓度依赖性。CDDP处理后,U-2OS细胞中WRAP53αm RNA的表达水平明显高于未处理的空白对照组(P<0.05),且呈浓度和时间依赖性;p53 m RNA及p53蛋白的表达水平高于空白对照组(P<0.05)。si WRAP53转染后,WRAP53α和p53 m RNA及p53蛋白的表达水平低于空白对照组(P<0.05)。CDDP单独给药组U-2OS细胞凋亡率高于si WRAP53α转染联合CDDP处理组(P<0.05),2组细胞的凋亡率均高于空白对照组(P<0.05)。结论:CDDP可抑制U-2OS细胞的增殖,诱导WRAP53α和p53 m RNA及p53蛋白的表达;干扰WRAP53α基因的表达可下调p53的表达水平,并逆转CDDP诱导的细胞凋亡。
基金The National Natural Science Foundation of China(No.60573117)the National Basic Research Program of China(973 Program)(No.2007CB310805)
文摘A web service wrapping approach for command line programs,which are commonly used in scientific computing,is proposed.First,software architecture for a basic web service wrapper implementation is given and the functions of the main components are explained.Then after a comprehensive analysis of data transmission and a job life cycle model,a novel proactive file transmission and job management mechanism is devised to enhance the software architecture,and the command line programs are wrapped into web services in such a way that they can efficiently transmit files,supply instant status feedback and automatically manage the jobs.Experiments show that the proposed approach achieves higher performance with less memory usage compared to the related work, and the usability is also improved.This work has already been put into use in a production system of scientific computing and the data processing efficiency of the system is greatly improved.
