The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardio...The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardiopulmonary resuscitation(ECPR) have demonstrated some benefits,high-quality manual CPR remained the essential first step,particularly in resource-limited settings.In this study,we examined whether opportunities existed to improve manual CPR performance using preliminary data from our recent survey conducted in a province in western China.We aim to emphasize the importance of improving manual CPR quality before implementing advanced interventions.展开更多
This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal dosages.The mechanism by which phosphate ester affects the setti...This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal dosages.The mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics simulations.Fourier transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane materials.The results demonstrate that a 1%concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of polyurethane.When phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component A.This reduction in interaction slows the setting time.Additionally,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.展开更多
OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 i...OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups:group A(acupuncture combined with atlantoaxial joint bone setting therapy group),group B(acupuncture group),and group C(tiapride group).After two months of treatment,the Yale global tic severity scale(YGTSS)score reduction,improvement in social function impairment,clinical efficacy,and long-term efficacy in the three groups were compared.RESULTS:After treatment,in the analysis of YGTSS score reduction,social function impairment improvement,the clinical control rate,and long-term efficacy,the results were all Group A>Group B>Group C,with a statistically significant difference(P<0.05).However,the total clinical efficacy of treatment in group A(94.9%)was not significantly different from that in group B(91.8%).Adverse reactions did not occur in groups A and B,and several adverse reactions occurred in 29%(n=58)of the group C patients.CONCLUSION:Compared with traditional drug therapy,acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy.This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.展开更多
Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)tria...Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.展开更多
The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Ma...The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Many scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated ambiguity.The goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site selection.The characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these uncertainties.To tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s method.Following this,an intelligent algorithm is suggested.The steps of the suggested algorithm are explained with an example that explains itself.The compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their viability.This study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,respectively.It uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior literature.It is simpler for the decisionmakers to look at each option separately because the decision is uncertain.Comparing the computed results,it is discovered that they are consistent and dependable because of their preferred properties.展开更多
Vertical position changes of ground-based Global Navigation Satellite System(GNSS) stations have been used to study regional terrestrial water storage(TWS) changes. However, the feasibility is still unclear in many ar...Vertical position changes of ground-based Global Navigation Satellite System(GNSS) stations have been used to study regional terrestrial water storage(TWS) changes. However, the feasibility is still unclear in many areas due to diverse local effects. This study aims to evaluate the capability of GNSS vertical displacements in monitoring hydrological variations in four climate settings over Chinese mainland. The spatial and temporal variations of hydrological load-induced(HYDL) vertical displacements at 208 GNSS sites during 2011-2020 were analyzed by comparing with Gravity Recovery and Climate Experiment(GRACE)/GRACE Follow-On(GFO) and Global Land Data Assimilation System(GLDAS) derived TWS changes. The results indicate that GNSS vertical positions show different capabilities in capturing seasonal and non-seasonal hydrological dynamics in different climate regions. Among the four climatic settings, the subtropical monsoon climate(SMC) region, with the largest deformation fluctuation(the regional mean root mean square(RMS) is 7.97 mm), has the highest regional mean HYDL-GRACE and HYDL-GLDAS anti-correlation coefficients(CCs) of-0.47 and-0.45 at the seasonal scale, respectively. For the individual GNSS site, the number of the sites with CC <-0.40 between HYDL and GRACE/GLDASderived TWS changes accounts for 55.1% and 55.1%(SMC), 13.0% and 7.4%(temperate monsoon climate, TMC), 6.7% and 13.3%(temperate continental climate, TCC), 32.3% and 38.7%(plateau climate,PC), respectively. For the non-seasonal term, although the proportion with CC <-0.40 in each climate type decreases mainly due to the influence of local geodynamic and human activities, especially in the SMC and PC regions, GNSS site vertical deformations still show good capability in monitoring hydrological extremes. The results provide valuable information for better application of GNSS to hydrology.展开更多
The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolc...The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolcanic rocks in the Belts that make up the Birimian Supergroup were intruded by granitoids during the Eburnean Orogeny.This research aims to classify granitoids in the Edikan Mine and ascertain the petrogenetic and geochemical characteristics of some auriferous granitoids in the wider Kumasi Basin,Ghana,to understand the implications for geodynamic settings.A multi-methods approach involving field studies,petrographic studies,and whole-rock geochemical analysis was used to achieve the goal of the study.Petrographic studies revealed a relatively high abundance of plagioclase and a low percentage of K-feldspars(anorthoclase and orthoclase)in the Fobinso samples,suggesting that the samples are granodioritic in nature,while the Esuajah samples showed relatively low plagioclase abundance and a high percentage in K-feldspars,indicating that they are granitic.The granitoids from the study areas are co-magmatic.The granitoids in Esuajah and Fobinso are generally enriched in large ion lithophile elements and light rare earth elements than high field strength elements,middle rare earth elements,and heavy rare earth elements,indicating mixing with crustal sources during the evolution of the granitoids.The granitoids were tectonically formed in a syn-collisional+VAG setting,which implies that they were formed in the subduction zone setting.Fobinso granodiorites showed S-type signatures with evidence of extensive crustal contamination,while the Esuajah granites showed I-type signatures with little or no crustal contamination and are peraluminous.Gold mineralization in the study area is structurally and lithologically controlled with shear zones,faulting,and veining as the principal structures controlling the mineralization.The late-stage vein,V3,in the Edikan Mine is characterized by a low vein angle and is mineralized.展开更多
Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This...Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This study proposes an intelligent approach for tool setting in vibration cutting using machine vision and hearing,divided into two steps.In the first step,machine vision is employed to achieve rough precision in tool setting within tens of micrometers.Subsequently,in the second step,machine hearing utilizes sound pickup to capture vibration audio signals,enabling fine tool adjustment within 1μm precision.The relationship between the spectral intensity of vibration audio and cutting depth is analyzed to establish criteria for tool–workpiece contact.Finally,the efficacy of this approach is validated on an ultra-precision platform,demonstrating that the automated tool-setting process takes no more than 74 s.The total cost of the vision and hearing sensors is less than$1500.展开更多
The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is o...The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is of key significance for determining the Early Paleozoic tectonic evolution and deep crust-mantle structure.Previous studies mainly focused on the Paleozoic granites;the coeval mafic rocks in this area are still poorly understood.A set of Late Silurian intraplate tholeiitic basalts has been discovered in Longshan area,providing key evidence for the mantle source and deep geodynamic background in this area.The Late Silurian Angou basalt has similar geochemical features as intraplate tholeiitic basalt,with high Na_(2)O/K_(2)O ratios(5.22-8.25),enriched in large ion lithophile elements and LREE.In combination with their relatively evolved Sr-Nd isotopic composition[^(87)Sr/^(86)Sr(i)=0.7128-0.7140;ε_(Nd)(t)=-5.55 to-3.40],it is suggested that it originated from decompression melting of metasomatized enriched mantle in extensional setting.These results indicate that the mantle source in the junction zone of the West Qinling-North Qilian orogenic belt evolved from depleted to enriched with the continuation of Proto-Tethys subduction from the Cambrian to the Silurian.These results are of great significance to understanding the genesis of contemporaneous granite and the crust-mantle interaction in the junction zone between the Western Qinling and Northern Qilian orogenic belt.展开更多
BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques...BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.展开更多
Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge w...Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge worldwide[1].According to data from the Institute for Health Metrics and Evaluation(IHME)and the World Health Organization(WHO),the gap in access to healthcare services between high-and low-income countries contributes to delayed detection,increased incidence of advanced-stage disease,and,consequently,higher mortality rates(up to 50%higher compared to high-income countries)[1,2].This translates into inequalities in access to screening and early diagnosis methods,which exacerbate the burden of this disease in low-resource settings where infrastructure,funding,and access to trained professionals are limited[3].展开更多
Point-of-care ultrasound(POCUS) is recognized as a valuable diagnostic tool,especially in resourcelimited settings(RLS).POCUS provides rapid diagnostic information that enables health professionals to make critical de...Point-of-care ultrasound(POCUS) is recognized as a valuable diagnostic tool,especially in resourcelimited settings(RLS).POCUS provides rapid diagnostic information that enables health professionals to make critical decisions at the bedside.^([1]) Despite the welldocumented benefits of POCUS,access to longitudinal,comprehensive training programs and a lack of trainee feedback are barriers to the widespread use of this technology in such settings.^([2])展开更多
The present study of metabasalts was carried out to understand the mantle source and geodynamic setting of the Mahakoshal Group in the Central Indian Tectonic Zone.In this study,we present detailed field,petrography,a...The present study of metabasalts was carried out to understand the mantle source and geodynamic setting of the Mahakoshal Group in the Central Indian Tectonic Zone.In this study,we present detailed field,petrography,and whole rock geochemistry of the Mahakoshal metabasalts.The Mahakoshal metabasalts are sub-alkaline in nature and belong to the tholeiitic series of rocks.The variation in rareearth element patterns of metabasalts indicates the different degrees of partial melting at shallow as well as deeper depths.Further,Eu/Eu*varies from 0.8 to 1.1(except sample KP-144=0.3),Ce/Ce*varies from 0.97 to 1.05,showing no cerium anomaly,and Nb/Nb*ranges from 0.7 to 1.3(except KP-144=0.1).The magnesium number(Mg#)varies from 0.2 to 0.3,which is quite low,indicating the evolved nature of the metabasalts.The studied metabasalts show E-MORB to OIB-type affinities,which are placed in the trench-distal back-arc setting.The opening of the Mahakoshal Basin is due to retreating orogen in the accretionary orogen setting and is contemporaneous with the assembly of the Columbia Supercontinent(~2.1-1.8 Ga).Hence,field,petrographic,and geochemical signatures indicate that the Mahakoshal basin opened as a back-arc rift basin on the Bundelkhand Craton,and that metabasalts are derived from the mantle that underwent variable degrees of partial melting at different depths.展开更多
Hepatitis E virus(HEV)represents a significant global cause of acute viral hepatitis.Annually,it is estimated to cause approximately 20.1 million infections worldwide,3.3 million of which result in symptomatic illness...Hepatitis E virus(HEV)represents a significant global cause of acute viral hepatitis.Annually,it is estimated to cause approximately 20.1 million infections worldwide,3.3 million of which result in symptomatic illness.In developing regions,genotypes HEV-1 and HEV-2 are the primary strains responsible for widespread outbreaks and epidemics of acute jaundice(icteric hepatitis),transmitted predominantly through the fecal-oral route via contaminated water and food(Devarbhavi et al.,2023).展开更多
During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is spr...During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is sprayed manually.Furthermore,it can also affect the permeability of the preform,resin injection and the quality of the vacuum assisted resin infusion(VARI)molding,resulting in a decrease in the mechanical properties of composite materials.This study utilizes dry fiber automated placement equipment and an automated spraying system to manufacture preform structures,followed by VARI process to prepare composite samples with varying setting agent contents.Subsequently,mechanical characterization including interlaminar shear,bending and tensile testing is conducted to investigate the influence of setting agent content on both the manufacturing process and the mechanical properties of composite products.The results show that the interlaminar shear strength,bending strength and tensile strength of the sample gradually decrease with the increase of the content of the setting agent.The optimal setting agent content for automated laying of dry fiber is determined to be 4%-6%,balancing the preformed body’s layup quality and its impact on mechanical properties.Compared with agent-free samples,this range results in reductions of 3% in interlaminar shear strength,9% in bending strength,11% in bending modulus,and 13%-16% in tensile strength.展开更多
Submodular optimization is primarily applied in multi-agent systems for tasks such as resource allocation,task assignment,collaborative decision-making,and optimization problems.Maximization of optimizing submodular s...Submodular optimization is primarily applied in multi-agent systems for tasks such as resource allocation,task assignment,collaborative decision-making,and optimization problems.Maximization of optimizing submodular set functions attracts much attention since the 1970s.A large body of work has been done using approximation algorithms.When the dimension of the independent variable of the set function changes from one tok,it is called ak-submodular set function.Thek-submodular set function,a generalization of the classical submodular set function,arises in diverse fields with varied applications.In many practical scenarios,quantifying the degree of closeness to submodularity becomes essential,leading to concepts such as approximately submodular set functions and the diminishing-return(DR) ratio.This paper investigates ak-dimensional set function under matroid constraints,which may lack full submodularity.Instead,we focus on an approximately non-ksubmodular set function characterized by its DR ratio.Employing a greedy algorithmic approach,we derive an approximation guarantee for this problem.Notably,when the DR ratio is set to one,our results align with existing findings in the literature.Experimental results demonstrate the superiority of our algorithm over the baselines.展开更多
Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional atten...Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional attention modules such as SE-Net,CBAM,ECA-Net,and CA adopt a deterministic paradigm,assigning fixed scalar weights to features without modeling ambiguity or confidence.To overcome these limitations,this paper proposes the Fuzzy Attention Network Layer(FANL),which integrates intuitionistic fuzzy set theory with convolutional neural networks to explicitly represent feature uncertainty through membership(μ),non-membership(ν),and hesitation(π)degrees.FANLconsists of four coremodules:(1)feature dimensionality reduction via global pooling,(2)fuzzymodeling using learnable clustering centers,(3)adaptive attention generation through weighted fusion of fuzzy components,and(4)feature refinement through residual connections.A cross-layer guidance mechanism is further introduced to enhance hierarchical feature propagation,allowing high-level semantic features to incorporate fine-grained texture information from shallow layers.Comprehensive experiments on three benchmark datasets—PathMNIST-30000,full PathMNIST,and Blood MNIST—demonstrate the effectiveness and generalizability of FANL.The model achieves 84.41±0.56%accuracy and a 1.69%improvement over the baseline CNN while maintaining lightweight computational complexity.Ablation studies show that removing any component causes a 1.7%–2.0%performance drop,validating the synergistic contribution of each module.Furthermore,FANL provides superior uncertainty calibration(ECE=0.0452)and interpretable selective prediction under uncertainty.Overall,FANL presents an efficient and uncertaintyaware attention framework that improves both accuracy and reliability,offering a promising direction for robust visual recognition under ambiguous or noisy conditions.展开更多
The sustainability of the Internet of Things(IoT)involves various issues,such as poor connectivity,scalability problems,interoperability issues,and energy inefficiency.Although the Sixth Generation of mobile networks(...The sustainability of the Internet of Things(IoT)involves various issues,such as poor connectivity,scalability problems,interoperability issues,and energy inefficiency.Although the Sixth Generation of mobile networks(6G)allows for Ultra-Reliable Low-Latency Communication(URLLC),enhanced Mobile Broadband(eMBB),and massive Machine-Type Communications(mMTC)services,it faces deployment challenges such as the short range of sub-THz and THz frequency bands,low capability to penetrate obstacles,and very high path loss.This paper presents a network architecture to enhance the connectivity of wireless IoT mesh networks that employ both 6G and Wi-Fi technologies.In this architecture,local communications are carried through the mesh network,which uses a virtual backbone to relay packets to local nodes,while remote communications are carried through the 6G network.The virtual backbone is created using a heuristic distributed ConnectedDominating Set(CDS)algorithm.In this algorithm,each node uses information collected from its one-and two-hop neighbors to determine its role and find the set of expansion nodes that are used to select the next CDS nodes.The proposed algorithm has O(n)message and O(K)time complexities,where n is the number of nodes in the network,and K is the depth of the cluster.The study proved that the approximation ratio of the algorithmhas an upper bound of 2.06748(3.4306MCDS+4.8185).Performance evaluations compared the size of the CDS against the theoretical limit and recent CDS clustering algorithms.Results indicate that the proposed algorithm has the smallest average slope for the size of the CDS as the number of nodes increases.展开更多
文摘The quality of cardiopulmonary resuscitation(CPR) significantly influences survival and neurological outcomes in patients with cardiac arrest(CA).Although mechanical chest compression devices and extracorporeal cardiopulmonary resuscitation(ECPR) have demonstrated some benefits,high-quality manual CPR remained the essential first step,particularly in resource-limited settings.In this study,we examined whether opportunities existed to improve manual CPR performance using preliminary data from our recent survey conducted in a province in western China.We aim to emphasize the importance of improving manual CPR quality before implementing advanced interventions.
基金Funded by the National Natural Science Foundation of China(No.52370128)the Fundamental Research Funds for the Central Universities(No.2572022AW54)。
文摘This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal dosages.The mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics simulations.Fourier transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane materials.The results demonstrate that a 1%concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of polyurethane.When phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component A.This reduction in interaction slows the setting time.Additionally,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.
基金Supported by Traditional Chinese medicine foundation of Zhejiang province:Clinical Study on the Correlation Between Tourette Syndrome and Anatomical Changes in the Atlantoaxial Joint(2010ZB162)Medical Health Science and Technology Project of Zhejiang Provincial Health Commission:Study on Protein Fingerprinting of Tourette Syndrome(2011KYB142)+1 种基金Renowned Traditional Chinese Medicine Expert Inheritance Studio Construction Project of Zhejiang province(No.GZS2020049)Key Disciplines of Traditional Chinese Medicine Foundation of Zhejiang Province(2012-XK-D20)。
文摘OBJECTIVE:To explore the efficacy and safety of acupuncture combined with atlantoaxial joint bone-setting therapy for the treatment of Tourette syndrome.METHODS:We randomly divided 600 patients at a ratio of 1∶1∶1 into three groups:group A(acupuncture combined with atlantoaxial joint bone setting therapy group),group B(acupuncture group),and group C(tiapride group).After two months of treatment,the Yale global tic severity scale(YGTSS)score reduction,improvement in social function impairment,clinical efficacy,and long-term efficacy in the three groups were compared.RESULTS:After treatment,in the analysis of YGTSS score reduction,social function impairment improvement,the clinical control rate,and long-term efficacy,the results were all Group A>Group B>Group C,with a statistically significant difference(P<0.05).However,the total clinical efficacy of treatment in group A(94.9%)was not significantly different from that in group B(91.8%).Adverse reactions did not occur in groups A and B,and several adverse reactions occurred in 29%(n=58)of the group C patients.CONCLUSION:Compared with traditional drug therapy,acupuncture combined with atlantoaxial joint bone setting therapy has better clinical and long-term efficacy.This treatment strategy can improve the social function of children and prevent adverse reactions to drugs.
基金supported by the National Natural Science Foundation of China(92162218,42302101,42202099)the Guizhou Provincial Natural Science Foundation(ZK[2023]477)。
文摘Unraveling the precise mineralization age is vital to understand the geodynamic setting and ore-forming mechanism of the sediment-hosted Pb-Zn deposit;this has long been a challenge.The Sichuan-Yunnan-Guizhou(SYG)triangle in the southwestern margin of the Yangtze Block is a globally recognized carbonate-hosted Pb-Zn metallogenic province and also an essential part of the South China low-temperature metallogenic domain.This region has>30 million tons(Mt)Zn and Pb resources and shows the enrichment of dispersed metals,such as Ga,Ge,Cd,Se,and Tl.During the past 2 decades,abundant data on mineralization ages of Pb-Zn deposits within the SYG triangle have been documented based on various radioisotopic dating methods,resulting in significant progress in understanding the geodynamic background and ore formation of Pb-Zn deposits hosted in sedimentary rocks at SYG triangle.This paper provides a comprehensive summary of the geochronological results and Pb-Sr isotopic data regarding Pb-Zn deposits in the SYG triangle,which identified two distinct Pb-Zn mineralization periods influencing the dynamic processes associated with the expansion and closure of the Paleo-Tethys Ocean in the western margin of the Yangtze Block.The predominant phase of Pb-Zn mineralization at SYG triangle spanned from the Middle Triassic to Early Jurassic(226-191 Ma),which was intensely correlated with the large-scale basin fluid transport triggered by the closure of the Paleo-Tethys Ocean and Indosinian orogeny.The secondary Pb-Zn mineralization phase occurred during the Late Devonian to Late Carboniferous and was controlled by extensional structures associated with the expansion of the Paleo-Tethys Ocean.Further investigation is necessary to clarify the occurrence and potential factors involved in the Pb-Zn mineralization events during the Late Devonian to Late Carboniferous.
文摘The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Many scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated ambiguity.The goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site selection.The characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these uncertainties.To tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s method.Following this,an intelligent algorithm is suggested.The steps of the suggested algorithm are explained with an example that explains itself.The compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their viability.This study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,respectively.It uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior literature.It is simpler for the decisionmakers to look at each option separately because the decision is uncertain.Comparing the computed results,it is discovered that they are consistent and dependable because of their preferred properties.
基金supported by National Natural Science Foundation of China(42064002,42004013,42204006)the GuangxiNatural Science Foundation of China(2024GXNSFDA010041)+5 种基金Guangdong Basic and Applied Basic Research Foundation(2022A1515010469)Guangxi Key Laboratory of Spatial Information and Geomatics(Grant no.21-238-21-05)the Open Fund of Hubei Luojia Laboratory(230100019,230100020)The GNSS observation data are provided by Crustal Movement Observation Network of China(CMONC)The GRACE/GFO mascon gravimetry data products are provided by NASA Jet Propulsion Laboratory/California Institute of TechnologyThe GLDAS data products are provided by NASA Earthdata.
文摘Vertical position changes of ground-based Global Navigation Satellite System(GNSS) stations have been used to study regional terrestrial water storage(TWS) changes. However, the feasibility is still unclear in many areas due to diverse local effects. This study aims to evaluate the capability of GNSS vertical displacements in monitoring hydrological variations in four climate settings over Chinese mainland. The spatial and temporal variations of hydrological load-induced(HYDL) vertical displacements at 208 GNSS sites during 2011-2020 were analyzed by comparing with Gravity Recovery and Climate Experiment(GRACE)/GRACE Follow-On(GFO) and Global Land Data Assimilation System(GLDAS) derived TWS changes. The results indicate that GNSS vertical positions show different capabilities in capturing seasonal and non-seasonal hydrological dynamics in different climate regions. Among the four climatic settings, the subtropical monsoon climate(SMC) region, with the largest deformation fluctuation(the regional mean root mean square(RMS) is 7.97 mm), has the highest regional mean HYDL-GRACE and HYDL-GLDAS anti-correlation coefficients(CCs) of-0.47 and-0.45 at the seasonal scale, respectively. For the individual GNSS site, the number of the sites with CC <-0.40 between HYDL and GRACE/GLDASderived TWS changes accounts for 55.1% and 55.1%(SMC), 13.0% and 7.4%(temperate monsoon climate, TMC), 6.7% and 13.3%(temperate continental climate, TCC), 32.3% and 38.7%(plateau climate,PC), respectively. For the non-seasonal term, although the proportion with CC <-0.40 in each climate type decreases mainly due to the influence of local geodynamic and human activities, especially in the SMC and PC regions, GNSS site vertical deformations still show good capability in monitoring hydrological extremes. The results provide valuable information for better application of GNSS to hydrology.
文摘The Edikan Mine,which consists of Fobinso and Esuajah gold deposits,lies within the Asankrangwa Gold Belt of the Birimian Supergroup in the Kumasi Basin.The metasedimentary rocks in the Basins and the faulted metavolcanic rocks in the Belts that make up the Birimian Supergroup were intruded by granitoids during the Eburnean Orogeny.This research aims to classify granitoids in the Edikan Mine and ascertain the petrogenetic and geochemical characteristics of some auriferous granitoids in the wider Kumasi Basin,Ghana,to understand the implications for geodynamic settings.A multi-methods approach involving field studies,petrographic studies,and whole-rock geochemical analysis was used to achieve the goal of the study.Petrographic studies revealed a relatively high abundance of plagioclase and a low percentage of K-feldspars(anorthoclase and orthoclase)in the Fobinso samples,suggesting that the samples are granodioritic in nature,while the Esuajah samples showed relatively low plagioclase abundance and a high percentage in K-feldspars,indicating that they are granitic.The granitoids from the study areas are co-magmatic.The granitoids in Esuajah and Fobinso are generally enriched in large ion lithophile elements and light rare earth elements than high field strength elements,middle rare earth elements,and heavy rare earth elements,indicating mixing with crustal sources during the evolution of the granitoids.The granitoids were tectonically formed in a syn-collisional+VAG setting,which implies that they were formed in the subduction zone setting.Fobinso granodiorites showed S-type signatures with evidence of extensive crustal contamination,while the Esuajah granites showed I-type signatures with little or no crustal contamination and are peraluminous.Gold mineralization in the study area is structurally and lithologically controlled with shear zones,faulting,and veining as the principal structures controlling the mineralization.The late-stage vein,V3,in the Edikan Mine is characterized by a low vein angle and is mineralized.
基金the financial support for this research provided by the National Natural Science Foundation of China(Grant Nos.52275470,124115301,and 52105458)the Natural Science Foundation of Beijing(Grant No.3222009).
文摘Vibration cutting has emerged as a promising method for creating surface functional microstructures.However,achieving precise tool setting is a time-consuming process that significantly impacts process efficiency.This study proposes an intelligent approach for tool setting in vibration cutting using machine vision and hearing,divided into two steps.In the first step,machine vision is employed to achieve rough precision in tool setting within tens of micrometers.Subsequently,in the second step,machine hearing utilizes sound pickup to capture vibration audio signals,enabling fine tool adjustment within 1μm precision.The relationship between the spectral intensity of vibration audio and cutting depth is analyzed to establish criteria for tool–workpiece contact.Finally,the efficacy of this approach is validated on an ultra-precision platform,demonstrating that the automated tool-setting process takes no more than 74 s.The total cost of the vision and hearing sensors is less than$1500.
基金supported by the National Natural Science Foundation of China(42172010,42372071,41102037)。
文摘The Longshan orogenic belt is located in the southwestern margin of Ordos Basin at the junction zone between the Western Qinling and Northern Qilian orogenic belt.Voluminous Early Paleozoic magmatism in this area is of key significance for determining the Early Paleozoic tectonic evolution and deep crust-mantle structure.Previous studies mainly focused on the Paleozoic granites;the coeval mafic rocks in this area are still poorly understood.A set of Late Silurian intraplate tholeiitic basalts has been discovered in Longshan area,providing key evidence for the mantle source and deep geodynamic background in this area.The Late Silurian Angou basalt has similar geochemical features as intraplate tholeiitic basalt,with high Na_(2)O/K_(2)O ratios(5.22-8.25),enriched in large ion lithophile elements and LREE.In combination with their relatively evolved Sr-Nd isotopic composition[^(87)Sr/^(86)Sr(i)=0.7128-0.7140;ε_(Nd)(t)=-5.55 to-3.40],it is suggested that it originated from decompression melting of metasomatized enriched mantle in extensional setting.These results indicate that the mantle source in the junction zone of the West Qinling-North Qilian orogenic belt evolved from depleted to enriched with the continuation of Proto-Tethys subduction from the Cambrian to the Silurian.These results are of great significance to understanding the genesis of contemporaneous granite and the crust-mantle interaction in the junction zone between the Western Qinling and Northern Qilian orogenic belt.
基金This retrospective analysis incorporated data from two clinical trials(CTR20220854 and CTR20222843)sponsored by Chongqing Chenan Biopharmaceutical Co.,Ltd.and Jiangsu Hengrui Pharmaceuticals Co.,Ltd.However,these sponsors did not partake in the study design,data interpretation,or manuscript preparation.
文摘BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.
文摘Breast cancer is the leading cause of cancer-related mortality in women globally,with its incidence continuing to rise,particularly in low-and middle-income countries,presenting a significant public health challenge worldwide[1].According to data from the Institute for Health Metrics and Evaluation(IHME)and the World Health Organization(WHO),the gap in access to healthcare services between high-and low-income countries contributes to delayed detection,increased incidence of advanced-stage disease,and,consequently,higher mortality rates(up to 50%higher compared to high-income countries)[1,2].This translates into inequalities in access to screening and early diagnosis methods,which exacerbate the burden of this disease in low-resource settings where infrastructure,funding,and access to trained professionals are limited[3].
文摘Point-of-care ultrasound(POCUS) is recognized as a valuable diagnostic tool,especially in resourcelimited settings(RLS).POCUS provides rapid diagnostic information that enables health professionals to make critical decisions at the bedside.^([1]) Despite the welldocumented benefits of POCUS,access to longitudinal,comprehensive training programs and a lack of trainee feedback are barriers to the widespread use of this technology in such settings.^([2])
文摘The present study of metabasalts was carried out to understand the mantle source and geodynamic setting of the Mahakoshal Group in the Central Indian Tectonic Zone.In this study,we present detailed field,petrography,and whole rock geochemistry of the Mahakoshal metabasalts.The Mahakoshal metabasalts are sub-alkaline in nature and belong to the tholeiitic series of rocks.The variation in rareearth element patterns of metabasalts indicates the different degrees of partial melting at shallow as well as deeper depths.Further,Eu/Eu*varies from 0.8 to 1.1(except sample KP-144=0.3),Ce/Ce*varies from 0.97 to 1.05,showing no cerium anomaly,and Nb/Nb*ranges from 0.7 to 1.3(except KP-144=0.1).The magnesium number(Mg#)varies from 0.2 to 0.3,which is quite low,indicating the evolved nature of the metabasalts.The studied metabasalts show E-MORB to OIB-type affinities,which are placed in the trench-distal back-arc setting.The opening of the Mahakoshal Basin is due to retreating orogen in the accretionary orogen setting and is contemporaneous with the assembly of the Columbia Supercontinent(~2.1-1.8 Ga).Hence,field,petrographic,and geochemical signatures indicate that the Mahakoshal basin opened as a back-arc rift basin on the Bundelkhand Craton,and that metabasalts are derived from the mantle that underwent variable degrees of partial melting at different depths.
文摘Hepatitis E virus(HEV)represents a significant global cause of acute viral hepatitis.Annually,it is estimated to cause approximately 20.1 million infections worldwide,3.3 million of which result in symptomatic illness.In developing regions,genotypes HEV-1 and HEV-2 are the primary strains responsible for widespread outbreaks and epidemics of acute jaundice(icteric hepatitis),transmitted predominantly through the fecal-oral route via contaminated water and food(Devarbhavi et al.,2023).
基金supported by Jiangsu Provincial Key Research and Development Program(No.BE2023014-4).
文摘During the automated placement process of dry fibers,the positioning and fixation of dry fiber gauze belts are achieved by spraying setting agents.The amount of the setting agent is difficult to control when it is sprayed manually.Furthermore,it can also affect the permeability of the preform,resin injection and the quality of the vacuum assisted resin infusion(VARI)molding,resulting in a decrease in the mechanical properties of composite materials.This study utilizes dry fiber automated placement equipment and an automated spraying system to manufacture preform structures,followed by VARI process to prepare composite samples with varying setting agent contents.Subsequently,mechanical characterization including interlaminar shear,bending and tensile testing is conducted to investigate the influence of setting agent content on both the manufacturing process and the mechanical properties of composite products.The results show that the interlaminar shear strength,bending strength and tensile strength of the sample gradually decrease with the increase of the content of the setting agent.The optimal setting agent content for automated laying of dry fiber is determined to be 4%-6%,balancing the preformed body’s layup quality and its impact on mechanical properties.Compared with agent-free samples,this range results in reductions of 3% in interlaminar shear strength,9% in bending strength,11% in bending modulus,and 13%-16% in tensile strength.
基金Supported by the Natural Science Foundation of Shandong Province (No.ZR2023MA031)the Natural Science Foundation of China (No.12201619)。
文摘Submodular optimization is primarily applied in multi-agent systems for tasks such as resource allocation,task assignment,collaborative decision-making,and optimization problems.Maximization of optimizing submodular set functions attracts much attention since the 1970s.A large body of work has been done using approximation algorithms.When the dimension of the independent variable of the set function changes from one tok,it is called ak-submodular set function.Thek-submodular set function,a generalization of the classical submodular set function,arises in diverse fields with varied applications.In many practical scenarios,quantifying the degree of closeness to submodularity becomes essential,leading to concepts such as approximately submodular set functions and the diminishing-return(DR) ratio.This paper investigates ak-dimensional set function under matroid constraints,which may lack full submodularity.Instead,we focus on an approximately non-ksubmodular set function characterized by its DR ratio.Employing a greedy algorithmic approach,we derive an approximation guarantee for this problem.Notably,when the DR ratio is set to one,our results align with existing findings in the literature.Experimental results demonstrate the superiority of our algorithm over the baselines.
文摘Deep learning attentionmechanisms have achieved remarkable progress in computer vision,but still face limitations when handling images with ambiguous boundaries and uncertain feature representations.Conventional attention modules such as SE-Net,CBAM,ECA-Net,and CA adopt a deterministic paradigm,assigning fixed scalar weights to features without modeling ambiguity or confidence.To overcome these limitations,this paper proposes the Fuzzy Attention Network Layer(FANL),which integrates intuitionistic fuzzy set theory with convolutional neural networks to explicitly represent feature uncertainty through membership(μ),non-membership(ν),and hesitation(π)degrees.FANLconsists of four coremodules:(1)feature dimensionality reduction via global pooling,(2)fuzzymodeling using learnable clustering centers,(3)adaptive attention generation through weighted fusion of fuzzy components,and(4)feature refinement through residual connections.A cross-layer guidance mechanism is further introduced to enhance hierarchical feature propagation,allowing high-level semantic features to incorporate fine-grained texture information from shallow layers.Comprehensive experiments on three benchmark datasets—PathMNIST-30000,full PathMNIST,and Blood MNIST—demonstrate the effectiveness and generalizability of FANL.The model achieves 84.41±0.56%accuracy and a 1.69%improvement over the baseline CNN while maintaining lightweight computational complexity.Ablation studies show that removing any component causes a 1.7%–2.0%performance drop,validating the synergistic contribution of each module.Furthermore,FANL provides superior uncertainty calibration(ECE=0.0452)and interpretable selective prediction under uncertainty.Overall,FANL presents an efficient and uncertaintyaware attention framework that improves both accuracy and reliability,offering a promising direction for robust visual recognition under ambiguous or noisy conditions.
基金Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia for funding this research work through the project number RI-44-0028.
文摘The sustainability of the Internet of Things(IoT)involves various issues,such as poor connectivity,scalability problems,interoperability issues,and energy inefficiency.Although the Sixth Generation of mobile networks(6G)allows for Ultra-Reliable Low-Latency Communication(URLLC),enhanced Mobile Broadband(eMBB),and massive Machine-Type Communications(mMTC)services,it faces deployment challenges such as the short range of sub-THz and THz frequency bands,low capability to penetrate obstacles,and very high path loss.This paper presents a network architecture to enhance the connectivity of wireless IoT mesh networks that employ both 6G and Wi-Fi technologies.In this architecture,local communications are carried through the mesh network,which uses a virtual backbone to relay packets to local nodes,while remote communications are carried through the 6G network.The virtual backbone is created using a heuristic distributed ConnectedDominating Set(CDS)algorithm.In this algorithm,each node uses information collected from its one-and two-hop neighbors to determine its role and find the set of expansion nodes that are used to select the next CDS nodes.The proposed algorithm has O(n)message and O(K)time complexities,where n is the number of nodes in the network,and K is the depth of the cluster.The study proved that the approximation ratio of the algorithmhas an upper bound of 2.06748(3.4306MCDS+4.8185).Performance evaluations compared the size of the CDS against the theoretical limit and recent CDS clustering algorithms.Results indicate that the proposed algorithm has the smallest average slope for the size of the CDS as the number of nodes increases.
