Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately m...Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately mark the primary breast tumor and positive axillary lymph nodes(ALNs)prior to NAT to ensure precise surgical excision,guide axillary downstaging,and guarantee reliable lesion retrieval for pathologic evaluation3.The false-negative rate of sentinel lymph node biopsy(SLNB)after NAT can be reduced to<10%by applying modalities,such as the identification of≥3 sentinel lymph nodes(SLNs)with dual-mapping techniques or removal of the marked lymph node with target axillary dissection(TAD)according to the ASCO,NCCN,and CBCS guidelines3-5.However,there is a lack of consensus regarding the optimal methods and materials for accurate marking6,7.Conventional techniques include clip placement,guidewire localization,and carbon or ink tattooing,whereas wireless technologies,such as MagseedR,radiofrequency identification tags,SAVI SCOUTR,and radioactive iodine-125(125I)seeds,have also been adopted.Traditional marking techniques have a localization failure rate of approximately 10%.In contrast,the use of 125I seeds(with a radiation dose of 0.1-0.3 mCi)has significantly improved localization accuracy8,9.Nevertheless,owing to radioactive properties,concerns have been raised regarding the potential impact of 125I seed marking on assessing the pathologic complete response(pCR)after NAT10.Moreover,whether the influence of 125I seed marking on pCR could lead to suboptimal adjuvant treatment decisions and potentially compromise long-term oncologic outcomes has not been established.To investigate the potential impact of 125I seed placement on the pCR rate and long-term outcomes in breast cancer patients receiving NAT,we conducted a retrospective cohort study utilizing propensity score matching(PSM).展开更多
Slow speed of the Next-Generation sequencing data analysis, compared to the latest high throughput sequencers such as HiSeq X system, using the current industry standard genome analysis pipeline, has been the major fa...Slow speed of the Next-Generation sequencing data analysis, compared to the latest high throughput sequencers such as HiSeq X system, using the current industry standard genome analysis pipeline, has been the major factor of data backlog which limits the real-time use of genomic data for precision medicine. This study demonstrates the DRAGEN Bio-IT Processor as a potential candidate to remove the “Big Data Bottleneck”. DRAGENTM accomplished the variant calling, for ~40× coverage WGS data in as low as ~30 minutes using a single command, achieving the over 50-fold data analysis speed while maintaining the similar or better variant calling accuracy than the standard GATK Best Practices workflow. This systematic comparison provides the faster and efficient NGS data analysis alternative to NGS-based healthcare industries and research institutes to meet the requirement for precision medicine based healthcare.展开更多
目的系统评价和整合MSM暴露前预防污名化体验的质性研究,为MSM实施针对性干预提供循证依据。方法检索Cochrane Library、PubMed、Embase、Web of Science、CINAHL、SinoMed、万方数据库、中国知网和维普数据库中关于MSM暴露前预防污名...目的系统评价和整合MSM暴露前预防污名化体验的质性研究,为MSM实施针对性干预提供循证依据。方法检索Cochrane Library、PubMed、Embase、Web of Science、CINAHL、SinoMed、万方数据库、中国知网和维普数据库中关于MSM暴露前预防污名化体验的质性研究,检索时限为建库至2024年9月。结果共纳入16篇基于国外研究的文献,提炼出57个研究结果,形成14个新类别,进一步归纳得到4个整合结果:污名化影响因素复杂、污名化存在多重表现、污名化影响日常生活、污名化应对策略多样。结论MSM暴露前预防污名化体验复杂,未来可借鉴国外研究,结合我国国情及文化背景,加强医护人员专业化培训,运用数字化工具积极实施综合性干预措施,联合家庭、社区构建整体化社会支持模式,帮助MSM减轻污名化体验。展开更多
Pseudoephedrine (PSE) is a widely used nasal decongestant. A review by the European Medicines Agency has reported that PSE may be associated with risks of posterior reversible encephalopathy syndrome (PRES) and revers...Pseudoephedrine (PSE) is a widely used nasal decongestant. A review by the European Medicines Agency has reported that PSE may be associated with risks of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS). PRES and RCVS are rare but serious conditions that affect cerebral blood flow. This review discusses the pharmacology of PSE and potential risks for PRES and RCVS and concludes that considering the common use of PSE, with over 70 million packs of PSE taken each year in the European Union and the United Kingdom, and the rare occurrence of PRES and RCVS, that the risks of developing PRES/RCVS on exposure to PSE are likely to be very low.展开更多
Wheat(Triticum aestivum L.)is an important staple food crop in the world and supplies about 20%of human caloric and protein consumption(Giraldo et al.,2019;Xiao et al.,2022).Wheat production accounts for~30%of global ...Wheat(Triticum aestivum L.)is an important staple food crop in the world and supplies about 20%of human caloric and protein consumption(Giraldo et al.,2019;Xiao et al.,2022).Wheat production accounts for~30%of global cereal crops(Li et al.,2019).With the global population increasing and the frequency of natural disasters rising,enhancing wheat yield is crucial to meet food demand.Spike traits such as increased grain number per spike are key determinants of wheat yield.Pre-harvest sprouting(PHS)is a significant natural disaster that severely impacts grain yield and end-use quality of wheat(Tai et al.,2021,2024).展开更多
A team of researchers from the University of Science and Technology of China(USTC)of the Chinese Academy of Sciences(CAS)and its partners have made significant advancements in random quantum circuit sampling with Zuch...A team of researchers from the University of Science and Technology of China(USTC)of the Chinese Academy of Sciences(CAS)and its partners have made significant advancements in random quantum circuit sampling with Zuchongzhi-3,a superconducting quantum computing prototype featuring 105 qubits and 182 couplers.展开更多
Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across vari...Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across various domains.However,the deployment of such models in resource-constrained environments presents a unique set of challenges that require innovative solutions.Resource-constrained environments encompass scenarios where computing resources,memory,and energy availability are restricted.To empower sentiment analysis in resource-constrained environments,we address the crucial need by leveraging lightweight pre-trained models.These models,derived from popular architectures such as DistilBERT,MobileBERT,ALBERT,TinyBERT,ELECTRA,and SqueezeBERT,offer a promising solution to the resource limitations imposed by these environments.By distilling the knowledge from larger models into smaller ones and employing various optimization techniques,these lightweight models aim to strike a balance between performance and resource efficiency.This paper endeavors to explore the performance of multiple lightweight pre-trained models in sentiment analysis tasks specific to such environments and provide insights into their viability for practical deployment.展开更多
The generation of terminology related to Rhetoric in pre-modern Japan evolved in roughly three phases.The first phase(1603-1771),dominated by linguistic contact with missionaries,rendered“Rhetorica”by direct katakan...The generation of terminology related to Rhetoric in pre-modern Japan evolved in roughly three phases.The first phase(1603-1771),dominated by linguistic contact with missionaries,rendered“Rhetorica”by direct katakana transliteration as retorika(レトリカ)or retōrika(レトーリカ)during the initial introduction of Western learning.This phase is characterized by knowledge transplantation primarily through transliteration.In the second phase(1771-1789),as Western knowledge was introduced more systematically via Chinese translations of Western works—especially through the dissemination of Xi Xue Fan and Tengaku shokan taiisho,which used Lèduólǐjiāas the translation of“Rhetorica”—Japanese intellectuals gained a preliminary,systematic understanding of the content,nature,and teaching methods of Western rhetoric.The third phase began in the Kansei era(1789),when the term giron was gradually adopted as a translation of Western logic and applied in related translation practices.By 1814,the term rhetorick was clearly translated as giron in Angeria gorin taisei.Research evidence suggests that the term giron originated from the“Giron no hō”proposed in Xi Xue Fan,and that this book clearly influenced the adoption of“giron”in Dutch-Japanese dictionaries.From the first to the third phase,both Japanese missionaries and Chinese intellectuals drew on Buddhist knowledge to introduce Western rhetoric,interpreting it through terms such as dangi,rongi and giron,thereby reframing it within the Buddhist concept of debate.After the Meiji period,giron was gradually abandoned and replaced by shūji.This shift in terminology not only marked the modernization of Japan’s rhetorical terminology system but also signaled a cognitive and identity transformation:Japanese intellectuals began to reposition China from an object of cultural identification to a cultural“Other”.展开更多
Dear Editor,Posterior reverse encephalopathy syndrome(PRES),manifests as a confusional state/delirium,convulsion,or acute blindness which illustrates in magnetic resonance imaging(MRI)typical bilateral white matter le...Dear Editor,Posterior reverse encephalopathy syndrome(PRES),manifests as a confusional state/delirium,convulsion,or acute blindness which illustrates in magnetic resonance imaging(MRI)typical bilateral white matter lesions.These clinical and radiological changes are reversible in two to three weeks,usually generated by acute hypertension,preeclampsia,eclampsia,immunosuppression,septicemia,and end-stage renal disease.PRES is commonly diagnosed in patients in their thirties.展开更多
We read with great interest the recent article by Valenzuela et al.1titled“Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease”published in the Journ...We read with great interest the recent article by Valenzuela et al.1titled“Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease”published in the Journal of Sport and Health Science The study's exploration of the effects of varying carbohydrate(CHO)doses on exercise capacity in Mc Ardle disease,a condition characterized by complete muscle glycogen unavailability,is a significant contribution to the field of sports science and metabolic disorders.展开更多
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82573747,82172873,W2421095,and 82503888)National Science and Technology Major Project(Grant No.2025ZD0543900)+2 种基金Natural Science Foundation of Shandong Province(Grant Nos.ZR2024LMB011 and ZR2024QH058)Taishan Scholars Program of Shandong Province(Grant No.tsqn202211337)Collaborative Academic Innovation Project of Shandong Cancer Hospital(Grant No.GF003).
文摘Neoadjuvant therapy(NAT)has become the standard treatment for patients with locally advanced breast cancer and stage II-III HER2-positive(HER2+)or triple-negative breast cancer(TNBC)1,2.It is essential to accurately mark the primary breast tumor and positive axillary lymph nodes(ALNs)prior to NAT to ensure precise surgical excision,guide axillary downstaging,and guarantee reliable lesion retrieval for pathologic evaluation3.The false-negative rate of sentinel lymph node biopsy(SLNB)after NAT can be reduced to<10%by applying modalities,such as the identification of≥3 sentinel lymph nodes(SLNs)with dual-mapping techniques or removal of the marked lymph node with target axillary dissection(TAD)according to the ASCO,NCCN,and CBCS guidelines3-5.However,there is a lack of consensus regarding the optimal methods and materials for accurate marking6,7.Conventional techniques include clip placement,guidewire localization,and carbon or ink tattooing,whereas wireless technologies,such as MagseedR,radiofrequency identification tags,SAVI SCOUTR,and radioactive iodine-125(125I)seeds,have also been adopted.Traditional marking techniques have a localization failure rate of approximately 10%.In contrast,the use of 125I seeds(with a radiation dose of 0.1-0.3 mCi)has significantly improved localization accuracy8,9.Nevertheless,owing to radioactive properties,concerns have been raised regarding the potential impact of 125I seed marking on assessing the pathologic complete response(pCR)after NAT10.Moreover,whether the influence of 125I seed marking on pCR could lead to suboptimal adjuvant treatment decisions and potentially compromise long-term oncologic outcomes has not been established.To investigate the potential impact of 125I seed placement on the pCR rate and long-term outcomes in breast cancer patients receiving NAT,we conducted a retrospective cohort study utilizing propensity score matching(PSM).
文摘Slow speed of the Next-Generation sequencing data analysis, compared to the latest high throughput sequencers such as HiSeq X system, using the current industry standard genome analysis pipeline, has been the major factor of data backlog which limits the real-time use of genomic data for precision medicine. This study demonstrates the DRAGEN Bio-IT Processor as a potential candidate to remove the “Big Data Bottleneck”. DRAGENTM accomplished the variant calling, for ~40× coverage WGS data in as low as ~30 minutes using a single command, achieving the over 50-fold data analysis speed while maintaining the similar or better variant calling accuracy than the standard GATK Best Practices workflow. This systematic comparison provides the faster and efficient NGS data analysis alternative to NGS-based healthcare industries and research institutes to meet the requirement for precision medicine based healthcare.
文摘目的系统评价和整合MSM暴露前预防污名化体验的质性研究,为MSM实施针对性干预提供循证依据。方法检索Cochrane Library、PubMed、Embase、Web of Science、CINAHL、SinoMed、万方数据库、中国知网和维普数据库中关于MSM暴露前预防污名化体验的质性研究,检索时限为建库至2024年9月。结果共纳入16篇基于国外研究的文献,提炼出57个研究结果,形成14个新类别,进一步归纳得到4个整合结果:污名化影响因素复杂、污名化存在多重表现、污名化影响日常生活、污名化应对策略多样。结论MSM暴露前预防污名化体验复杂,未来可借鉴国外研究,结合我国国情及文化背景,加强医护人员专业化培训,运用数字化工具积极实施综合性干预措施,联合家庭、社区构建整体化社会支持模式,帮助MSM减轻污名化体验。
文摘Pseudoephedrine (PSE) is a widely used nasal decongestant. A review by the European Medicines Agency has reported that PSE may be associated with risks of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS). PRES and RCVS are rare but serious conditions that affect cerebral blood flow. This review discusses the pharmacology of PSE and potential risks for PRES and RCVS and concludes that considering the common use of PSE, with over 70 million packs of PSE taken each year in the European Union and the United Kingdom, and the rare occurrence of PRES and RCVS, that the risks of developing PRES/RCVS on exposure to PSE are likely to be very low.
基金supported by the National Key Research and Development Program of China(2023YFD1200403 and 2023YFF1000600)the Innovation Program of Chinese Academy of Agricultural Sciences。
文摘Wheat(Triticum aestivum L.)is an important staple food crop in the world and supplies about 20%of human caloric and protein consumption(Giraldo et al.,2019;Xiao et al.,2022).Wheat production accounts for~30%of global cereal crops(Li et al.,2019).With the global population increasing and the frequency of natural disasters rising,enhancing wheat yield is crucial to meet food demand.Spike traits such as increased grain number per spike are key determinants of wheat yield.Pre-harvest sprouting(PHS)is a significant natural disaster that severely impacts grain yield and end-use quality of wheat(Tai et al.,2021,2024).
文摘A team of researchers from the University of Science and Technology of China(USTC)of the Chinese Academy of Sciences(CAS)and its partners have made significant advancements in random quantum circuit sampling with Zuchongzhi-3,a superconducting quantum computing prototype featuring 105 qubits and 182 couplers.
文摘Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across various domains.However,the deployment of such models in resource-constrained environments presents a unique set of challenges that require innovative solutions.Resource-constrained environments encompass scenarios where computing resources,memory,and energy availability are restricted.To empower sentiment analysis in resource-constrained environments,we address the crucial need by leveraging lightweight pre-trained models.These models,derived from popular architectures such as DistilBERT,MobileBERT,ALBERT,TinyBERT,ELECTRA,and SqueezeBERT,offer a promising solution to the resource limitations imposed by these environments.By distilling the knowledge from larger models into smaller ones and employing various optimization techniques,these lightweight models aim to strike a balance between performance and resource efficiency.This paper endeavors to explore the performance of multiple lightweight pre-trained models in sentiment analysis tasks specific to such environments and provide insights into their viability for practical deployment.
基金Research leading to this paper was funded by the NSSFC Post-Funding Project(22FZXB088)Guizhou University Research Project in Humanities and Social Sciences(GDYB2022007).
文摘The generation of terminology related to Rhetoric in pre-modern Japan evolved in roughly three phases.The first phase(1603-1771),dominated by linguistic contact with missionaries,rendered“Rhetorica”by direct katakana transliteration as retorika(レトリカ)or retōrika(レトーリカ)during the initial introduction of Western learning.This phase is characterized by knowledge transplantation primarily through transliteration.In the second phase(1771-1789),as Western knowledge was introduced more systematically via Chinese translations of Western works—especially through the dissemination of Xi Xue Fan and Tengaku shokan taiisho,which used Lèduólǐjiāas the translation of“Rhetorica”—Japanese intellectuals gained a preliminary,systematic understanding of the content,nature,and teaching methods of Western rhetoric.The third phase began in the Kansei era(1789),when the term giron was gradually adopted as a translation of Western logic and applied in related translation practices.By 1814,the term rhetorick was clearly translated as giron in Angeria gorin taisei.Research evidence suggests that the term giron originated from the“Giron no hō”proposed in Xi Xue Fan,and that this book clearly influenced the adoption of“giron”in Dutch-Japanese dictionaries.From the first to the third phase,both Japanese missionaries and Chinese intellectuals drew on Buddhist knowledge to introduce Western rhetoric,interpreting it through terms such as dangi,rongi and giron,thereby reframing it within the Buddhist concept of debate.After the Meiji period,giron was gradually abandoned and replaced by shūji.This shift in terminology not only marked the modernization of Japan’s rhetorical terminology system but also signaled a cognitive and identity transformation:Japanese intellectuals began to reposition China from an object of cultural identification to a cultural“Other”.
文摘Dear Editor,Posterior reverse encephalopathy syndrome(PRES),manifests as a confusional state/delirium,convulsion,or acute blindness which illustrates in magnetic resonance imaging(MRI)typical bilateral white matter lesions.These clinical and radiological changes are reversible in two to three weeks,usually generated by acute hypertension,preeclampsia,eclampsia,immunosuppression,septicemia,and end-stage renal disease.PRES is commonly diagnosed in patients in their thirties.
文摘We read with great interest the recent article by Valenzuela et al.1titled“Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease”published in the Journal of Sport and Health Science The study's exploration of the effects of varying carbohydrate(CHO)doses on exercise capacity in Mc Ardle disease,a condition characterized by complete muscle glycogen unavailability,is a significant contribution to the field of sports science and metabolic disorders.
