Taking the Changli Institute of Pomology,Hebei Academy of Agriculture and Forestry Sciences(hereinafter referred to as the Changli Institute of Pomology)as a case study,this paper explores the practical pathways throu...Taking the Changli Institute of Pomology,Hebei Academy of Agriculture and Forestry Sciences(hereinafter referred to as the Changli Institute of Pomology)as a case study,this paper explores the practical pathways through which Party building leads to the high-quality development of fruit tree research from three dimensions:theoretical convergence points,current development status,and functional mechanisms.It proposes that Party building should focus on its core roles of steering political direction,enhancing team cohesion,and upholding ethical standards.Deep integration of Party building and scientific research should be achieved through concrete platforms,with the effectiveness measured by breakthroughs in critical"bottleneck"technologies and increased income for fruit growers.The study aims to provide a practical reference for integrating Party building with professional work in the agricultural research sector.展开更多
Following the proposal of the“Emerging Engineering Education(EEE)”initiative,the cultivation of interdisciplinary innovative talents has gained increasing prominence.Currently,there exists a significant gap between ...Following the proposal of the“Emerging Engineering Education(EEE)”initiative,the cultivation of interdisciplinary innovative talents has gained increasing prominence.Currently,there exists a significant gap between the practical innovation capabilities of automotive majors in vocational colleges and the evolving demands of the industry.To address deficiencies in interdisciplinary innovative talent development programs,this study proposes an educational framework structured around“One Core,Two Dimensions,Three Levels.”Leveraging a project-driven teaching methodology and utilizing CATIA—the industry-standard 3D design software—as a central tool,we have developed a closed-loop teaching model integrating theory,modeling,simulation,and evaluation.This model underpins a newly designed automotive engineering practicum aimed at nurturing high-quality engineering talents equipped with three critical competencies:solving complex engineering challenges,digital design proficiency,and cross-disciplinary collaborative innovation.The proposed approach demonstrates potential to alleviate the structural disconnect between traditional engineering pedagogy and industry talent requirements.展开更多
Under the background of information technology in education,there is insufficient integration of technological knowledge,pedagogical knowledge,and subject content knowledge in the teaching of propositions in high scho...Under the background of information technology in education,there is insufficient integration of technological knowledge,pedagogical knowledge,and subject content knowledge in the teaching of propositions in high school mathematics.Teachers mostly equate information technology with multimedia presentations,and students often memorize formulas mechanically,which leads to difficulties in the application of complex propositions.In this study,we take“the cosine formula of the difference between two angles”as an example.Based on the TPACK framework,we use contextual teaching and geometric drawing board demonstration to integrate subject content,pedagogical knowledge,and technological knowledge in teaching design and practice.It is found that by dynamically displaying the derivation process of the formula and guiding students to explore independently,it can help them understand the logic of the formula and improve their application ability.This study provides a paradigm for teaching propositions in high school mathematics and suggests that the TPACK framework can facilitate knowledge integration and cultivate students’mathematical literacy such as problem posing and creative inquiry,which is of great significance for teaching practice.展开更多
This paper introduces the experience and practice in constructing the practical teaching system for the course“Electric Machine and Drive.”In response to the current status of cultivating innovative practical abilit...This paper introduces the experience and practice in constructing the practical teaching system for the course“Electric Machine and Drive.”In response to the current status of cultivating innovative practical abilities among electrical engineering majors,based on the independently developed virtual simulation experimental teaching platform for Electric Machine and Drive,a stepped practical teaching process consisting of“classroom teaching-experimental teaching-comprehensive training-scientific inquiry”has been elaborately designed.A hierarchical practical teaching model for the second classroom has also been established.With teaching objectives as the optimization index,the teaching content,methods and means have been optimized;the teaching process has been organized and implemented in the form of team collaboration,thus constructing a comprehensive,stepped,hierarchical,and closed-loop innovative practical teaching system.This achievement provides references and assistance for the practical teaching of the same or similar majors in other colleges and universities.展开更多
Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This co...Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This condition is thought to affect approximately 2%of the Western population,with diagnosis peaking in early adulthood[2].Vitamin D,a fat-soluble vitamin,is essential for phospho-calcium metabolism,calcium homeostasis,and bone health.展开更多
A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative ...A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative refinement.This paper examines the pathways of smart course development in higher vocational education by using the Study Tour Course Design course as a practical case study.The analysis is conducted from four perspectives:innovation in educational concepts,innovation in teaching models,transformation in learning paradigms,and enhancement in evaluation systems.By developing a threedimensional framework encompassing“knowledge,skills,and problems”,the focus of education shifts from“knowledge imparting”to“competency development”.This approach fosters a transformation in teaching interactions,moving beyond the traditional“teacher and student interaction”to a more integrated trinity collaboration of“teachers,students,and machines”,and promotes the transformation of students’learning from“passive receptive learning”to“autonomous inquiry-based learning”.Simultaneously,it facilitates the transition of evaluation methods from“outcome-based evaluation”to“multi-dimensional evaluation”.展开更多
Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrat...Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrated significant associations between CRC risk and various serum metabolites as well as inflammatory cytokines;however,due to limitations in study design and potential confounding factors,the causal relationships remain unclear.This study aims to investigate the causal relationships between inflammatory cytokines,serum metabolites,and CRC risk,providing a theoretical basis for the development of novel early diagnostic biomarkers and therapeutic targets.Methods:A two-sample Mendelian randomization(MR)design was applied using summary statistics from genome-wide association studies(GWAS).Instrumental variables(IVs)were derived from:1)metabolomics GWAS data of 1400 serum metabolites(n=8299);2)cytokine GWAS data of 91 inflammatory factors(n=14824);and 3)CRC risk data from the FinnGen consortium(6847 cases and 314193 controls).The primary analysis was conducted using the inverse-variance weighted(IVW)method,with sensitivity analyses performed using MR Egger regression and the weighted median method.Effect estimates including odds ratios(OR),95%confidence intervals(CI),and false discovery rates(FDR)were calculated.Results:MR analysis indicated that higher levels of axin-1(AXIN1)(OR=0.84195%CI 0.714 to 0.991)and Fms-related tyrosine kinase 3 ligand(Flt3L)(OR=0.916,95%CI 0.844 to 0.994)were associated with a reduced risk of CRC.In contrast,higher levels of Delta/Notchlike epidermal growth factor-related receptor(DNER)(OR=1.119,95%CI 1.009 to 1.241)and vascular endothelial growth factor A(VEGF-A)(OR=1.078,95%CI 1.011 to 1.150)were associated with an increased risk of CRC(all P<0.05).Metabolomics association analysis further identified 144 serum metabolites significantly correlated with these four key inflammatory cytokines(FDR<0.05),suggesting that they may regulate CRC risk through inflammatory pathways.Conclusion:Specific inflammatory cytokines and serum metabolites have causal relationships with the risk of CRC.These findings provide insights for further exploration of potential risk factors and the development of effective prevention strategies for CRC.展开更多
Objective:To describe the implementation of evidence-based practice(EBP)and identify the associated factors among clinical nurses working at an oncology hospital in Central Vietnam.Methods:A cross-sectional study was ...Objective:To describe the implementation of evidence-based practice(EBP)and identify the associated factors among clinical nurses working at an oncology hospital in Central Vietnam.Methods:A cross-sectional study was conducted with 190 clinical nurses recruited from an oncology hospital in Central Vietnam.The self-administered Evidence-Based Practice Questionnaire(EBPQ)was employed to assess the nurses'knowledge/skills,attitudes,and implementation of EBP.Data analysis utilized descriptive statistics,the Mann-Whitney test,the Kruskal-Wallis test,and Spearman's rho correlation.Results:The mean total score for EBP implementation among the nurses was 29.52(SD=7.14)out of 42 scores.The most frequently undertaken activity was sharing evidence with colleagues,whereas finding relevant evidence was the least performed.The level of EBP implementation significantly varied based on the nurses'role types and their participation in related courses(P<0.05).Moreover,a strong positive correlation was observed between EBP implementation and both knowledge/skills(r=0.703,P<0.001)and attitudes toward EBP(r=0.536,P<0.001).Conclusions:The implementation of EBP by oncology nurses is generally moderate and is significantly positively correlated with their knowledge/skills and attitudes toward EBP.These findings underscore the importance of enhancing educational programs and facilitating suppor tive institutional policies to fur ther encourage the adoption of EBP among nurses.展开更多
In molybdenum chemistry,the oxidative addition of o-quinone or 1,2-dicarbonyl compounds to molybdenum has been widely used in Mo-catalyzed C—C bond construction.The carbonyl oxidative addition to Mo(0)or Mo(Ⅱ)is the...In molybdenum chemistry,the oxidative addition of o-quinone or 1,2-dicarbonyl compounds to molybdenum has been widely used in Mo-catalyzed C—C bond construction.The carbonyl oxidative addition to Mo(0)or Mo(Ⅱ)is the critical elementary reaction of molybdenum catalysis.However,the relevant density functional theory(DFT)studies are relatively scarce,especially regarding the rational selection of functionals.In this work,14 functionals were employed to investigate the Mo-catalyzed carbonyl oxidative addition step.A benchmark study was carried out to evaluate their performance in structure optimization and energy calculation.Analyses of mean absolute error(MAE)and mean squared error(MSE)indicated that the B3LYP-D3(BJ),TPSSh,and ωB97X-D functionals exhibited superior performance in structure optimization.Using the DLPNO-CCSD(T)functional as the reference,the M06,M06-L,and MN15-L functionals exhibited good performance for energy calculation based on the structures optimized using the B3LYP-D3(BJ)functional.In particular,MN15-L provided the best performance with the smallest MAE and MSE.展开更多
Objective:To identify the root causes of typical adverse drug events through the lens of patient experiences proposing novel strategies to mitigate preventable harm.Methods:A qualitative case study leveraging in-depth...Objective:To identify the root causes of typical adverse drug events through the lens of patient experiences proposing novel strategies to mitigate preventable harm.Methods:A qualitative case study leveraging in-depth interviews with patients and families,anchored by Interactive Patient Par ticipation Theory,to analyze 4 high-severity adverse drug events(ADE)cases.Cases were purposively sampled from 8 communities in China's National Adverse Event Monitor Center(2018-2023).Semi-structured interviews explored patient perspectives,with data analyzed via thematic coding and triangulation against clinical records.Results:Five interconnected themes emerged:(1)erosion of trust,(2)communication breakdowns,(3)information asymmetry,(4)environmental inadequacies,and(5)technological alienation.Notably,75% of participants had≤high school education,and 50% used≥7 medications daily,compounding ADE risks.Conclusions:We considered elements mentioned by theory,exploring trust,communication,information,and suppor t as the root causes.In addition,we added“adaptability to new technology”as an impor tant and necessary component.It is impor tant and necessary to analyze typical adverse drug events from the perspectives of patients.展开更多
Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching t...Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching the construction of an emergency care system based on the concept of“linkage”,delving into its theoretical foundations,exploring innovative construction models,and analyzing practical cases.The study indicates that an emergency care system under the“linkage”concept can effectively integrate resources and enhance efficiency,providing new insights for improving the construction of the emergency care system.It aims to promote the development of the emergency care system towards a more scientific,efficient,and collaborative direction.展开更多
To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was struct...To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was structured around a project titled"Influenza Virus Analysis",comprising four progressive modules:database utilization and information retrieval,sequence alignment and phylogenetic analysis,functional and structural prediction,and omics data analysis.These modules were integrated into a coherent research workflow that connected fragmented knowledge and technical skills.During implementation,flipped classroom and group collaboration methods were employed,alongside the establishment of a diversified assessment system emphasizing process evaluation.Teaching practice indicates that the reform effectively enhances students professional application skills,learning experience,and scientific literacy,facilitating a shift from"tool operation"to"problem-solving"capabilities.This study provides a reference model for the reform of bioinformatics experimental teaching in local universities.展开更多
The deep integration of artificial intelligence technology and agricultural industry has pushed smart agriculture into a new stage of"AI+scenario",and put forward a transformation requirement for the talent ...The deep integration of artificial intelligence technology and agricultural industry has pushed smart agriculture into a new stage of"AI+scenario",and put forward a transformation requirement for the talent cultivation of smart agriculture major in universities from"technology application"to"intelligent innovation".In response to the problems of insufficient AI integration,lack of contextualization,and insufficient collaboration between industry and education in the traditional"technology+"practical course system,this paper takes the smart agriculture major at Yulin Normal University as an example to construct a"AI+agriculture"practical course reconstruction framework and propose a four-dimensional transformation path of"goal-content-mode-evaluation".Through the practical exploration of modular curriculum design,scenario based practical design,integration of industry and education,and intelligent evaluation reform,a practical teaching system with local application-oriented university characteristics has been formed,providing a reference example for the cultivation of smart agriculture professionals under the background of new agricultural science.展开更多
China ranked first worldwide in the production and export of electric bicycles.As an emerging market for electric bicycles,Malaysia holds significant potential for trade collabor ation with China in this sector.This s...China ranked first worldwide in the production and export of electric bicycles.As an emerging market for electric bicycles,Malaysia holds significant potential for trade collabor ation with China in this sector.This study presents a compar ative analysis of the national electric bicycle standards in China and Malaysia,offering technical insights from a standardization perspective.These insights aim to support Chinese enterprises in strategically positioning their technologies in the Malaysian market.The findings reveal significant differences in technical parameters,safety requirements,and testing methods,highlighting the need for tailored product adapt ation.展开更多
This paper investigates the teaching reform of the Program Comprehension and Analysis course in the context of industry-education integration and AI empowerment.To align with the evolving needs of the software industr...This paper investigates the teaching reform of the Program Comprehension and Analysis course in the context of industry-education integration and AI empowerment.To align with the evolving needs of the software industry,the course content has been updated to incorporate AI techniques such as large language models and deep learning.The reform enriches educational resources and introduces innovative instructional approaches.In addition,high-quality practical teaching cases have been developed,and immersive,hands-on learning experiences have been designed based on industrial platforms and real-world applications.These initiatives aim to enhance the practical skills and innovative thinking of professional degree graduate students,fostering high-caliber talent that aligns with industry demands.A survey of 90 graduate students revealed high levels of satisfaction regarding course content,teaching methodology,and skill development.The reform has proven effective in cultivating interdisciplinary professionals with solid foundations in software engineering and AI-driven innovation.展开更多
Objective:To analyze the effectiveness of an integrated teaching platform combining virtual reality(VR)technology and high-end simulators in practical obstetrics and gynecology teaching.Methods:A total of 39 interns w...Objective:To analyze the effectiveness of an integrated teaching platform combining virtual reality(VR)technology and high-end simulators in practical obstetrics and gynecology teaching.Methods:A total of 39 interns who underwent obstetrics and gynecology internships from March 2023 to March 2024 were included in the reference group and received conventional practical teaching methods.Another 39 interns who underwent internships from April 2024 to April 2025 were included in the observation group and received the integrated teaching platform combining VR and high-end simulators.The teaching effects of the two groups were compared.Results:The observation group achieved higher assessment scores than the reference group,with higher scores in self-directed learning ability and clinical thinking ability after teaching,as well as higher teaching satisfaction(p<0.05).Conclusion:The integrated teaching platform combining VR and high-end simulators can improve the assessment scores of obstetrics and gynecology interns,cultivate their self-directed learning ability and clinical thinking ability,and achieve high teaching satisfaction.展开更多
BACKGROUND Gastrointestinal endoscopy technology has significantly improved the diagnostic accuracy and the successful treatment of gastrointestinal diseases.However,a series of ethical issues have emerged,such as exp...BACKGROUND Gastrointestinal endoscopy technology has significantly improved the diagnostic accuracy and the successful treatment of gastrointestinal diseases.However,a series of ethical issues have emerged,such as expanding treatment indications,which affect the fair distribution of medical resources.There is limited research on ethical issues in the field of digestive endoscopy.AIM To investigate the level of ethical awareness among gastrointestinal endoscopy practitioners and analyze the ethical issues involved in gastrointestinal endoscopy technology.METHODS A questionnaire survey was performed to collect relevant data(gender,age,degree of education,professional title,personnel category,the level of understanding medical ethical principles,ethics training and its learning pathways)from gastrointestinal endoscopy practitioners at the Second Hospital of Dalian Medical University and Dalian Friendship Hospital,including licensed physicians and nurses(including trainees and graduate students).RESULTS The majority of gastrointestinal endoscopy practitioners have received training on ethics,but there is still considerable room for improvement in their ethical awareness.Different learning pathways may affect the mastery of ethical principles, and understanding of ethical principles is more easily achieved through hospital ethics institutions.CONCLUSIONTo address the ethical issues in gastrointestinal endoscopy technology, it is necessary to enhance the humanisticeducation of gastrointestinal endoscopy practitioners, incorporate ethical standards into the technology assessmentprocess, and establish a patient-centered diagnostic and treatment model to improve the ethical awareness of practitionersand achieve a balance between technology and ethics.展开更多
Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective fact...Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective factors on frailty transition by constructing a Protection Index(PI)to guide targeted interventions.Methods Data were extracted from the 4th Sample Survey of the Aged Population in Urban and Rural China,including baseline(2017)and follow-up(2019)surveys.Frailty was assessed using the Frailty Index(FI),whereas the PI measured protective factors.Frailty transitions over 2 years were analyzed prospectively.Pearson’s correlation examined the relationship between FI and PI,and logistic regression assessed the effects of PI on frailty transitions.Results This study included 9,093 older adults.FI values increased with age and were higher in women,whereas PI values decreased with age and were higher in men.Over 2 years,56.2%of the participants showed a stable frailty status,14.2%improved,and 29.6%worsened.Negative transitions were more common than positive transitions,with transitions occurring most frequently between adjacent states.The PI was moderately negatively correlated with the FI(r=−0.349,P<0.001).A higher PI was associated with a lower risk of negative transitions among robust and prefrail individuals(OR=0.989,0.981,both P<0.05),but showed no significant effect among those with existing frailty.Conclusion Negative frailty transitions were more common with advancing age.Enhancing PI may help prevent negative frailty transitions among robust and pre-frail older adults,underscoring the value of early interventions.展开更多
Guided by the significant theoretical principle of the“Two Integrations”and grounded in Marxist cultural theory as its methodological basis,this paper constructs a bidirectional interpretative model linking“Yellow ...Guided by the significant theoretical principle of the“Two Integrations”and grounded in Marxist cultural theory as its methodological basis,this paper constructs a bidirectional interpretative model linking“Yellow River Culture”with“Cultural Confidence”.It proposes an integrated“Objective-Content-Path-Support”framework.Through the synergy of three-dimensional objectives,adaptation of stratified content,innovation in four-dimensional pathways,and support from a three-dimensional guarantee system,this framework establishes a closed-loop operational mechanism of“Curriculum-Practice-Evaluation-Feedback”.The study focuses on core issues in integrating Yellow River culture into university education practices,such as content construction,methodological pathways,and institutional guarantees.It aims to provide a systematic reference for universities to fulfill their fundamental task of“fostering virtue and cultivating talent”and to serve the national strategies for ecological protection and high-quality development in the Yellow River Basin.展开更多
The development of wheat cultivars with improved nitrogen(N),phosphorus(P),and potassium(K)use efficiency is essential for sustainable agriculture.Genetic dissection and identification of causative genes underlying nu...The development of wheat cultivars with improved nitrogen(N),phosphorus(P),and potassium(K)use efficiency is essential for sustainable agriculture.Genetic dissection and identification of causative genes underlying nutrient use efficiency represent a key strategy toward this goal.We conducted an extensive genome-wide association study(GWAS)using a panel of 431 wheat cultivars,identifying 1,659 significant single-nucleotide polymorphisms(SNPs)(LOD>5)through genotyping-by-sequencing.This analysis revealed 534 quantitative trait loci(QTLs)associated with 12 nutrient use efficiency traits across five distinct environments,among which 14 QTLs were consistently detected in at least three environments.Notably,meta-QTL analysis,showed that QTL80(72.12–74.24 Mb,chr2A),QTL387(32.88–33.56 Mb,chr6A),and QTL500(535.53–540.80 Mb,chr7B)exhibit clear co-localization with MQTL-2A-2,MQTL-6A-1,and MQTL-7B-2,respectively.This overlap highlights their robustness across diverse environmental conditions.Within these regions,critical candidate genes-including members of the bZIP transcription factor family and a potassium transporter gene-were identified in relation to nutrient use efficiency.Furthermore,a novel locus,QTL234,was discovered,harboring key candidate genes such as dof zinc finger protein,Ankyrin repeat family protein,and cytochrome P450.To validate the SNP within QTL234 associated with nitrogen harvest index(NHI),we developed a dCAPS marker for AX-109095537.These findings demonstrate the effectiveness of high-resolution SNP-based GWAS in rapidly pinpointing promising candidate genes.They also establish a foundation for large-scale QTL fine mapping,candidate gene validation,and the development of functional markers essential for enhancing nutrient use efficiency in wheat breeding programs.展开更多
基金Supported by Qinhuangdao Social Sciences Development Research Project(2025LX378).
文摘Taking the Changli Institute of Pomology,Hebei Academy of Agriculture and Forestry Sciences(hereinafter referred to as the Changli Institute of Pomology)as a case study,this paper explores the practical pathways through which Party building leads to the high-quality development of fruit tree research from three dimensions:theoretical convergence points,current development status,and functional mechanisms.It proposes that Party building should focus on its core roles of steering political direction,enhancing team cohesion,and upholding ethical standards.Deep integration of Party building and scientific research should be achieved through concrete platforms,with the effectiveness measured by breakthroughs in critical"bottleneck"technologies and increased income for fruit growers.The study aims to provide a practical reference for integrating Party building with professional work in the agricultural research sector.
文摘Following the proposal of the“Emerging Engineering Education(EEE)”initiative,the cultivation of interdisciplinary innovative talents has gained increasing prominence.Currently,there exists a significant gap between the practical innovation capabilities of automotive majors in vocational colleges and the evolving demands of the industry.To address deficiencies in interdisciplinary innovative talent development programs,this study proposes an educational framework structured around“One Core,Two Dimensions,Three Levels.”Leveraging a project-driven teaching methodology and utilizing CATIA—the industry-standard 3D design software—as a central tool,we have developed a closed-loop teaching model integrating theory,modeling,simulation,and evaluation.This model underpins a newly designed automotive engineering practicum aimed at nurturing high-quality engineering talents equipped with three critical competencies:solving complex engineering challenges,digital design proficiency,and cross-disciplinary collaborative innovation.The proposed approach demonstrates potential to alleviate the structural disconnect between traditional engineering pedagogy and industry talent requirements.
文摘Under the background of information technology in education,there is insufficient integration of technological knowledge,pedagogical knowledge,and subject content knowledge in the teaching of propositions in high school mathematics.Teachers mostly equate information technology with multimedia presentations,and students often memorize formulas mechanically,which leads to difficulties in the application of complex propositions.In this study,we take“the cosine formula of the difference between two angles”as an example.Based on the TPACK framework,we use contextual teaching and geometric drawing board demonstration to integrate subject content,pedagogical knowledge,and technological knowledge in teaching design and practice.It is found that by dynamically displaying the derivation process of the formula and guiding students to explore independently,it can help them understand the logic of the formula and improve their application ability.This study provides a paradigm for teaching propositions in high school mathematics and suggests that the TPACK framework can facilitate knowledge integration and cultivate students’mathematical literacy such as problem posing and creative inquiry,which is of great significance for teaching practice.
基金Project of the 14th Five-Year Plan for Educational Science in Liaoning Province(JG24DB234)Project of Graduate Education and Teaching Reform Research in Liaoning Province(LNYJG2023115)。
文摘This paper introduces the experience and practice in constructing the practical teaching system for the course“Electric Machine and Drive.”In response to the current status of cultivating innovative practical abilities among electrical engineering majors,based on the independently developed virtual simulation experimental teaching platform for Electric Machine and Drive,a stepped practical teaching process consisting of“classroom teaching-experimental teaching-comprehensive training-scientific inquiry”has been elaborately designed.A hierarchical practical teaching model for the second classroom has also been established.With teaching objectives as the optimization index,the teaching content,methods and means have been optimized;the teaching process has been organized and implemented in the form of team collaboration,thus constructing a comprehensive,stepped,hierarchical,and closed-loop innovative practical teaching system.This achievement provides references and assistance for the practical teaching of the same or similar majors in other colleges and universities.
基金supported by the National Natural Science Foundation of China(Grant Nos.82573974 and 82373475)to Z.Y.
文摘Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This condition is thought to affect approximately 2%of the Western population,with diagnosis peaking in early adulthood[2].Vitamin D,a fat-soluble vitamin,is essential for phospho-calcium metabolism,calcium homeostasis,and bone health.
基金Sponsored by Vocational Education Teaching Reform Research Project of Shandong Province“Research on Digital New-Form Curriculum Development Based on AI Knowledge Maps in the Context of Industry-Education Integration”(2023352)Vocational Education Teaching Reform Research Project of Shandong Province“Innovation and Practice in the Development Model of Vocational College Master Craftsman Studios under the Perspective of Industry-Education Integration”(2024375).
文摘A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative refinement.This paper examines the pathways of smart course development in higher vocational education by using the Study Tour Course Design course as a practical case study.The analysis is conducted from four perspectives:innovation in educational concepts,innovation in teaching models,transformation in learning paradigms,and enhancement in evaluation systems.By developing a threedimensional framework encompassing“knowledge,skills,and problems”,the focus of education shifts from“knowledge imparting”to“competency development”.This approach fosters a transformation in teaching interactions,moving beyond the traditional“teacher and student interaction”to a more integrated trinity collaboration of“teachers,students,and machines”,and promotes the transformation of students’learning from“passive receptive learning”to“autonomous inquiry-based learning”.Simultaneously,it facilitates the transition of evaluation methods from“outcome-based evaluation”to“multi-dimensional evaluation”.
基金supported by the Natural Science Foundation of Hunan Province (2022JJ30987)the Key Research and Development Project of Hunan Province (2024JK2107),China。
文摘Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrated significant associations between CRC risk and various serum metabolites as well as inflammatory cytokines;however,due to limitations in study design and potential confounding factors,the causal relationships remain unclear.This study aims to investigate the causal relationships between inflammatory cytokines,serum metabolites,and CRC risk,providing a theoretical basis for the development of novel early diagnostic biomarkers and therapeutic targets.Methods:A two-sample Mendelian randomization(MR)design was applied using summary statistics from genome-wide association studies(GWAS).Instrumental variables(IVs)were derived from:1)metabolomics GWAS data of 1400 serum metabolites(n=8299);2)cytokine GWAS data of 91 inflammatory factors(n=14824);and 3)CRC risk data from the FinnGen consortium(6847 cases and 314193 controls).The primary analysis was conducted using the inverse-variance weighted(IVW)method,with sensitivity analyses performed using MR Egger regression and the weighted median method.Effect estimates including odds ratios(OR),95%confidence intervals(CI),and false discovery rates(FDR)were calculated.Results:MR analysis indicated that higher levels of axin-1(AXIN1)(OR=0.84195%CI 0.714 to 0.991)and Fms-related tyrosine kinase 3 ligand(Flt3L)(OR=0.916,95%CI 0.844 to 0.994)were associated with a reduced risk of CRC.In contrast,higher levels of Delta/Notchlike epidermal growth factor-related receptor(DNER)(OR=1.119,95%CI 1.009 to 1.241)and vascular endothelial growth factor A(VEGF-A)(OR=1.078,95%CI 1.011 to 1.150)were associated with an increased risk of CRC(all P<0.05).Metabolomics association analysis further identified 144 serum metabolites significantly correlated with these four key inflammatory cytokines(FDR<0.05),suggesting that they may regulate CRC risk through inflammatory pathways.Conclusion:Specific inflammatory cytokines and serum metabolites have causal relationships with the risk of CRC.These findings provide insights for further exploration of potential risk factors and the development of effective prevention strategies for CRC.
文摘Objective:To describe the implementation of evidence-based practice(EBP)and identify the associated factors among clinical nurses working at an oncology hospital in Central Vietnam.Methods:A cross-sectional study was conducted with 190 clinical nurses recruited from an oncology hospital in Central Vietnam.The self-administered Evidence-Based Practice Questionnaire(EBPQ)was employed to assess the nurses'knowledge/skills,attitudes,and implementation of EBP.Data analysis utilized descriptive statistics,the Mann-Whitney test,the Kruskal-Wallis test,and Spearman's rho correlation.Results:The mean total score for EBP implementation among the nurses was 29.52(SD=7.14)out of 42 scores.The most frequently undertaken activity was sharing evidence with colleagues,whereas finding relevant evidence was the least performed.The level of EBP implementation significantly varied based on the nurses'role types and their participation in related courses(P<0.05).Moreover,a strong positive correlation was observed between EBP implementation and both knowledge/skills(r=0.703,P<0.001)and attitudes toward EBP(r=0.536,P<0.001).Conclusions:The implementation of EBP by oncology nurses is generally moderate and is significantly positively correlated with their knowledge/skills and attitudes toward EBP.These findings underscore the importance of enhancing educational programs and facilitating suppor tive institutional policies to fur ther encourage the adoption of EBP among nurses.
基金Project supported by the Fundamental Research Funds for the Central Universities(No.2042025kf0052)。
文摘In molybdenum chemistry,the oxidative addition of o-quinone or 1,2-dicarbonyl compounds to molybdenum has been widely used in Mo-catalyzed C—C bond construction.The carbonyl oxidative addition to Mo(0)or Mo(Ⅱ)is the critical elementary reaction of molybdenum catalysis.However,the relevant density functional theory(DFT)studies are relatively scarce,especially regarding the rational selection of functionals.In this work,14 functionals were employed to investigate the Mo-catalyzed carbonyl oxidative addition step.A benchmark study was carried out to evaluate their performance in structure optimization and energy calculation.Analyses of mean absolute error(MAE)and mean squared error(MSE)indicated that the B3LYP-D3(BJ),TPSSh,and ωB97X-D functionals exhibited superior performance in structure optimization.Using the DLPNO-CCSD(T)functional as the reference,the M06,M06-L,and MN15-L functionals exhibited good performance for energy calculation based on the structures optimized using the B3LYP-D3(BJ)functional.In particular,MN15-L provided the best performance with the smallest MAE and MSE.
基金supported by the Science and Technology Fund Project of Guizhou Health Commission(gzwkj2025-163)。
文摘Objective:To identify the root causes of typical adverse drug events through the lens of patient experiences proposing novel strategies to mitigate preventable harm.Methods:A qualitative case study leveraging in-depth interviews with patients and families,anchored by Interactive Patient Par ticipation Theory,to analyze 4 high-severity adverse drug events(ADE)cases.Cases were purposively sampled from 8 communities in China's National Adverse Event Monitor Center(2018-2023).Semi-structured interviews explored patient perspectives,with data analyzed via thematic coding and triangulation against clinical records.Results:Five interconnected themes emerged:(1)erosion of trust,(2)communication breakdowns,(3)information asymmetry,(4)environmental inadequacies,and(5)technological alienation.Notably,75% of participants had≤high school education,and 50% used≥7 medications daily,compounding ADE risks.Conclusions:We considered elements mentioned by theory,exploring trust,communication,information,and suppor t as the root causes.In addition,we added“adaptability to new technology”as an impor tant and necessary component.It is impor tant and necessary to analyze typical adverse drug events from the perspectives of patients.
文摘Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching the construction of an emergency care system based on the concept of“linkage”,delving into its theoretical foundations,exploring innovative construction models,and analyzing practical cases.The study indicates that an emergency care system under the“linkage”concept can effectively integrate resources and enhance efficiency,providing new insights for improving the construction of the emergency care system.It aims to promote the development of the emergency care system towards a more scientific,efficient,and collaborative direction.
基金Supported by Undergraduate Higher Education Teaching Quality and Reform Projects of Guangdong Province(Yuejiao Gao Han[2024]No.9,Yuejiao Gao Han[2024]No.30)Guangdong Basic and Applied Basic Research Foundation(2023A1515110973)+1 种基金Guangdong Provincial Young Innovative Talents Project of General Colleges and Universities(2023KQNCX089)Quality Engineering and Teaching Reform Projects of Zhaoqing University(zlgc202239,zlgc202207,zlgc2024005,zlgc2024038).
文摘To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was structured around a project titled"Influenza Virus Analysis",comprising four progressive modules:database utilization and information retrieval,sequence alignment and phylogenetic analysis,functional and structural prediction,and omics data analysis.These modules were integrated into a coherent research workflow that connected fragmented knowledge and technical skills.During implementation,flipped classroom and group collaboration methods were employed,alongside the establishment of a diversified assessment system emphasizing process evaluation.Teaching practice indicates that the reform effectively enhances students professional application skills,learning experience,and scientific literacy,facilitating a shift from"tool operation"to"problem-solving"capabilities.This study provides a reference model for the reform of bioinformatics experimental teaching in local universities.
基金Supported by the Autonomous Region-level Research and Practice Projects for New Engineering,New Medicine,New Agriculture,and New Humanities of Guangxi Department of Education(XNK202409)the Undergraduate Teaching Reform Project of Guangxi Higher Education(2024JGB332+1 种基金2024JGA304)the Guangxi Degree and Graduate Education Reform Project(JGY2025382).
文摘The deep integration of artificial intelligence technology and agricultural industry has pushed smart agriculture into a new stage of"AI+scenario",and put forward a transformation requirement for the talent cultivation of smart agriculture major in universities from"technology application"to"intelligent innovation".In response to the problems of insufficient AI integration,lack of contextualization,and insufficient collaboration between industry and education in the traditional"technology+"practical course system,this paper takes the smart agriculture major at Yulin Normal University as an example to construct a"AI+agriculture"practical course reconstruction framework and propose a four-dimensional transformation path of"goal-content-mode-evaluation".Through the practical exploration of modular curriculum design,scenario based practical design,integration of industry and education,and intelligent evaluation reform,a practical teaching system with local application-oriented university characteristics has been formed,providing a reference example for the cultivation of smart agriculture professionals under the background of new agricultural science.
文摘China ranked first worldwide in the production and export of electric bicycles.As an emerging market for electric bicycles,Malaysia holds significant potential for trade collabor ation with China in this sector.This study presents a compar ative analysis of the national electric bicycle standards in China and Malaysia,offering technical insights from a standardization perspective.These insights aim to support Chinese enterprises in strategically positioning their technologies in the Malaysian market.The findings reveal significant differences in technical parameters,safety requirements,and testing methods,highlighting the need for tailored product adapt ation.
基金supported by Project of Higher Education Teaching Reform Research in Heilongjiang Province(Graduate Education)(Grant No.SJGYY2024030).
文摘This paper investigates the teaching reform of the Program Comprehension and Analysis course in the context of industry-education integration and AI empowerment.To align with the evolving needs of the software industry,the course content has been updated to incorporate AI techniques such as large language models and deep learning.The reform enriches educational resources and introduces innovative instructional approaches.In addition,high-quality practical teaching cases have been developed,and immersive,hands-on learning experiences have been designed based on industrial platforms and real-world applications.These initiatives aim to enhance the practical skills and innovative thinking of professional degree graduate students,fostering high-caliber talent that aligns with industry demands.A survey of 90 graduate students revealed high levels of satisfaction regarding course content,teaching methodology,and skill development.The reform has proven effective in cultivating interdisciplinary professionals with solid foundations in software engineering and AI-driven innovation.
基金2024 Undergraduate Teaching Reform Research Project,Department of Education of Shandong Province,2025 Key Project of University-Level Education and Teaching Reform and Research,Research Title:Research on Talent Demand in the Biomedical Industry Chain and Strategies for High-Quality Higher Education Talent Cultivation in Shandong Province under the Background of New Quality Productivity(Project No.:Z2024208)Shandong Second Medical University,Research Title:Construction and Application of an Integrated Teaching Platform Combining Virtual Simulation and High-Fidelity Simulators in Obstetrics and Gynecology Practice Teaching,Project No.:2025SJZX053)。
文摘Objective:To analyze the effectiveness of an integrated teaching platform combining virtual reality(VR)technology and high-end simulators in practical obstetrics and gynecology teaching.Methods:A total of 39 interns who underwent obstetrics and gynecology internships from March 2023 to March 2024 were included in the reference group and received conventional practical teaching methods.Another 39 interns who underwent internships from April 2024 to April 2025 were included in the observation group and received the integrated teaching platform combining VR and high-end simulators.The teaching effects of the two groups were compared.Results:The observation group achieved higher assessment scores than the reference group,with higher scores in self-directed learning ability and clinical thinking ability after teaching,as well as higher teaching satisfaction(p<0.05).Conclusion:The integrated teaching platform combining VR and high-end simulators can improve the assessment scores of obstetrics and gynecology interns,cultivate their self-directed learning ability and clinical thinking ability,and achieve high teaching satisfaction.
文摘BACKGROUND Gastrointestinal endoscopy technology has significantly improved the diagnostic accuracy and the successful treatment of gastrointestinal diseases.However,a series of ethical issues have emerged,such as expanding treatment indications,which affect the fair distribution of medical resources.There is limited research on ethical issues in the field of digestive endoscopy.AIM To investigate the level of ethical awareness among gastrointestinal endoscopy practitioners and analyze the ethical issues involved in gastrointestinal endoscopy technology.METHODS A questionnaire survey was performed to collect relevant data(gender,age,degree of education,professional title,personnel category,the level of understanding medical ethical principles,ethics training and its learning pathways)from gastrointestinal endoscopy practitioners at the Second Hospital of Dalian Medical University and Dalian Friendship Hospital,including licensed physicians and nurses(including trainees and graduate students).RESULTS The majority of gastrointestinal endoscopy practitioners have received training on ethics,but there is still considerable room for improvement in their ethical awareness.Different learning pathways may affect the mastery of ethical principles, and understanding of ethical principles is more easily achieved through hospital ethics institutions.CONCLUSIONTo address the ethical issues in gastrointestinal endoscopy technology, it is necessary to enhance the humanisticeducation of gastrointestinal endoscopy practitioners, incorporate ethical standards into the technology assessmentprocess, and establish a patient-centered diagnostic and treatment model to improve the ethical awareness of practitionersand achieve a balance between technology and ethics.
基金supported by grants from the National Key R&D Program of China[Grant Nos.2020YFC2003000 and 2020YFC2003001]the National High Level Hospital Clinical Research Funding(BJ-2023-074 and BJ-2023-018)+1 种基金Beijing Municipal Science&Technology Commission“AI+Health Collaborative Innovation Cultivation”Project(Z221100003522015)the Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2021-JKCS-024).
文摘Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective factors on frailty transition by constructing a Protection Index(PI)to guide targeted interventions.Methods Data were extracted from the 4th Sample Survey of the Aged Population in Urban and Rural China,including baseline(2017)and follow-up(2019)surveys.Frailty was assessed using the Frailty Index(FI),whereas the PI measured protective factors.Frailty transitions over 2 years were analyzed prospectively.Pearson’s correlation examined the relationship between FI and PI,and logistic regression assessed the effects of PI on frailty transitions.Results This study included 9,093 older adults.FI values increased with age and were higher in women,whereas PI values decreased with age and were higher in men.Over 2 years,56.2%of the participants showed a stable frailty status,14.2%improved,and 29.6%worsened.Negative transitions were more common than positive transitions,with transitions occurring most frequently between adjacent states.The PI was moderately negatively correlated with the FI(r=−0.349,P<0.001).A higher PI was associated with a lower risk of negative transitions among robust and prefrail individuals(OR=0.989,0.981,both P<0.05),but showed no significant effect among those with existing frailty.Conclusion Negative frailty transitions were more common with advancing age.Enhancing PI may help prevent negative frailty transitions among robust and pre-frail older adults,underscoring the value of early interventions.
基金Philosophy and Social Sciences Research Project of Shandong Higher Education Institutions:“Research on the Double Helix Mechanism of Yellow River Culture Empowering Ideological and Political Education in Universities from the Perspective of Cultural Confidence Cultivation”(2025ZSYB077)Youth Key Project of Shandong Humanities and Social Sciences Research Project,“Research on Integrating Yellow River Culture into the Cultivation of University Students’Cultural Confidence”Shandong Higher Education Institutions Young Innovation Team Program:“Yellow River Delta Ecological Protection and Governance Innovation Team”(2023RW036).
文摘Guided by the significant theoretical principle of the“Two Integrations”and grounded in Marxist cultural theory as its methodological basis,this paper constructs a bidirectional interpretative model linking“Yellow River Culture”with“Cultural Confidence”.It proposes an integrated“Objective-Content-Path-Support”framework.Through the synergy of three-dimensional objectives,adaptation of stratified content,innovation in four-dimensional pathways,and support from a three-dimensional guarantee system,this framework establishes a closed-loop operational mechanism of“Curriculum-Practice-Evaluation-Feedback”.The study focuses on core issues in integrating Yellow River culture into university education practices,such as content construction,methodological pathways,and institutional guarantees.It aims to provide a systematic reference for universities to fulfill their fundamental task of“fostering virtue and cultivating talent”and to serve the national strategies for ecological protection and high-quality development in the Yellow River Basin.
基金funded by the National Key R&D Program of China(2021YFD1900700)。
文摘The development of wheat cultivars with improved nitrogen(N),phosphorus(P),and potassium(K)use efficiency is essential for sustainable agriculture.Genetic dissection and identification of causative genes underlying nutrient use efficiency represent a key strategy toward this goal.We conducted an extensive genome-wide association study(GWAS)using a panel of 431 wheat cultivars,identifying 1,659 significant single-nucleotide polymorphisms(SNPs)(LOD>5)through genotyping-by-sequencing.This analysis revealed 534 quantitative trait loci(QTLs)associated with 12 nutrient use efficiency traits across five distinct environments,among which 14 QTLs were consistently detected in at least three environments.Notably,meta-QTL analysis,showed that QTL80(72.12–74.24 Mb,chr2A),QTL387(32.88–33.56 Mb,chr6A),and QTL500(535.53–540.80 Mb,chr7B)exhibit clear co-localization with MQTL-2A-2,MQTL-6A-1,and MQTL-7B-2,respectively.This overlap highlights their robustness across diverse environmental conditions.Within these regions,critical candidate genes-including members of the bZIP transcription factor family and a potassium transporter gene-were identified in relation to nutrient use efficiency.Furthermore,a novel locus,QTL234,was discovered,harboring key candidate genes such as dof zinc finger protein,Ankyrin repeat family protein,and cytochrome P450.To validate the SNP within QTL234 associated with nitrogen harvest index(NHI),we developed a dCAPS marker for AX-109095537.These findings demonstrate the effectiveness of high-resolution SNP-based GWAS in rapidly pinpointing promising candidate genes.They also establish a foundation for large-scale QTL fine mapping,candidate gene validation,and the development of functional markers essential for enhancing nutrient use efficiency in wheat breeding programs.
