The enhanced mountain-to-plain convective storms in Beijing on 22 May 2021 were simulated using the highresolution Weather Research and Forecasting model,enabling detailed analyses of convective instability characteri...The enhanced mountain-to-plain convective storms in Beijing on 22 May 2021 were simulated using the highresolution Weather Research and Forecasting model,enabling detailed analyses of convective instability characteristics and underlying causes of stability variations.Generalized potential temperature outperformed traditional potential temperature and equivalent potential temperature in capturing instability variations associated with mid-level latent heating and near-surface evaporative cooling.Local instability variance was primarily governed by potential divergence and the advection of potential instability,with these factors exhibiting out-of-phase distributions.Prior to the onset of heavy precipitation,intense downdrafts transported unstable air from higher levels into more stable regions at lower levels,increasing local near-surface instability,which contributed to the formation of heavy precipitation.During the heavy precipitation stage,vertical divergence between slantwise updrafts and downdrafts in the lowmiddle stable layers led to destabilization,supporting sustained convective development within the precipitation area.At the leading edge of the heavy precipitation,instability enhancement was primarily driven by vertical advection,and less stable air in the lower levels was transported upward,enhancing instability at higher levels.展开更多
In this study, the ground potential rise(GPR) phenomenon caused by a lightning current injected into a field-shaped artificial grounding grid, as well as the potential difference between two different nodes at the edg...In this study, the ground potential rise(GPR) phenomenon caused by a lightning current injected into a field-shaped artificial grounding grid, as well as the potential difference between two different nodes at the edge of the grounding grid, was observed and analyzed under artificially triggered lightning conditions. Based on circuit theory and measured current data, a π-equivalent circuit was established to simulate the transient response of the grounding grid.Nineteen return strokes from three artificially triggered lightning events were analyzed. The peak currents of the 19 return strokes range from -6.7 to -25.1 kA, and the mean value was -14.3 kA. The GPR decreased rapidly and formed a subpeak after reaching the initial peak, with the mean value of the initial peak being -148.65 kV and the mean value of the subpeak being -92.87 kV. The GPR induced by the triggered lightning currents exhibited a subpeak phenomenon. Simulation results indicate that the subpeak phenomenon is related to localized corrosion of the vertical grounding electrode. The potential difference at the grounding grid edge exhibited a multi-pulse waveform with alternating polarity, dominated by positive pulses. The peak values of both the positive and negative polarity pulses gradually decreased, with the first positive pulse displaying a significantly higher intensity than that of subsequent pulses.展开更多
Addiction,a complex and chronic neurobiological disorder,is characterized by compulsive substance use despite harmful consequences,leading to persistent alterations in brain function,particularly within the reward,mot...Addiction,a complex and chronic neurobiological disorder,is characterized by compulsive substance use despite harmful consequences,leading to persistent alterations in brain function,particularly within the reward,motivation,and decision-making systems.Despite the availability of a range of treatment options,including pharmacotherapy and behavioral therapies,relapse remains a major challenge,with many individuals struggling to maintain long-term recovery.Current treatments often show limited efficacy,underscoring the need for novel therapeutic strategies that can address the underlying neurobiological disruptions in addiction.展开更多
Conjugated microporous polymers(CMPs)are a unique class of organic porous materials characterized byπ-conjugated structures and permanent micropores,distinguishing them from non-porous polymers and conventionalπ-con...Conjugated microporous polymers(CMPs)are a unique class of organic porous materials characterized byπ-conjugated structures and permanent micropores,distinguishing them from non-porous polymers and conventionalπ-conjugated polymers.CMPs offer extensive versatility in synthetic approaches,enabling the synthesis of cross-linked and mesoporous structures.Advances in chemical processes,structural design,and synthesis methodologies have been developed,resulting in a diverse range of CMPs with unique configurations and properties,contributing to the fast expansion of the field.CMPs are particularly notable for their ability to enable the competitive utilization ofπ-conjugated structures within mesoporous configurations,making them valuable for investigations across various domains.They have shown considerable promise in addressing fuel and environmental challenges,demonstrated by their exceptional performance in applications such as vapor adsorption,heterogeneous catalysis,light emission,light harvesting,and energy generation.This review examines the chemical engineering principles underlying CMPs,including synthesis approaches,systemic research advancements,multifunctional investigations boundaries,potential applications,and progress in synthesis,dimensionality,and morphology studies.Specifically,it offers a comparative analysis of CMPs and linear polymeric materials,aiding in the development of functional polymers.Furthermore,this review explores the primary fundamental limitations of CMPs in fuel-related domains and discusses alternative strategies,including novel synthesis methods incorporating interactions and morphologies,to address these challenges.Ultimately,this assessment aims to provide a valuable and inspiring resource for professionals in the field of fuel management,guiding future research and development efforts.展开更多
Adult neurogenesis is generally considered to be very limited;however,there is increasing evidence that this phenomenon is conserved across species.Traditionally,research has focused on identifying precursor cells,tho...Adult neurogenesis is generally considered to be very limited;however,there is increasing evidence that this phenomenon is conserved across species.Traditionally,research has focused on identifying precursor cells,those that are actively dividing or have the potential to divide.Direct evidence of adult neurogenesis has been found in rats,mice,songbirds,and nonhuman primates.In humans,while the evidence is indirect,it strongly suggests that neurogenesis also occurs during adulthood.In mammals,this active neurogenesis is preserved by radial glial progenitors,which remain in specific niches in the subventricular zone of the lateral ventricles and in the subgranular zone of the hippocampal dentate gyrus(Kumar et al.,2019).展开更多
This study presents a multi-physical modeling approach to analyze the dynamics of moisture potential and stress-deformation features near deep desiccation cracks in clayey soils under three consecutive years’climate ...This study presents a multi-physical modeling approach to analyze the dynamics of moisture potential and stress-deformation features near deep desiccation cracks in clayey soils under three consecutive years’climate variability in an arid region.A triple research approach of statistical analysis,analytical framework,and numerical modeling was used to investigate the complex thermo-hydro-mechanical behavior of desiccation-cracked soil,incorporating realistic climatic data of Qom,Iran.The results revealed the interplay between stress,strain,and pore water pressure over time,demonstrating that soil experiences significant swelling and shrinkage due to cyclic wetting and drying.The horizontal stress distribution shows compressive stress concentration at crack tips during wetting,transitioning to tensile stresses uniformly across the soil surface during drying paths.Similarly,vertical stress distributions exhibit localized compressive stresses along crack boundaries during wetting and tensile stresses during drying,highlighting the critical stress conditions at crack tips.The model differentiates between microstructural and macrostructural changes in porosity.Annual trends in micro-porosity revealed cyclic-dependent behavior,with significant volumetric changes occurring in the first year,stabilizing with successive cycles.The results also indicated that part of the volumetric changes are irreversible,with volumetric plastic strain increasing exponentially but at a decreasing rate over three years.Principal stress analysis indicates a shift from compressive to tensile stress states around cracks,driven by climate-induced wetting and drying cycles.These findings underscore the critical role of climate variability in shaping cracked soil behavior in arid regions,providing insights into the heterogeneous behavior of cracked soil surfFicial layers.展开更多
The paper considers the initial value problem of inhomogeneous fourth-order Schr¨odinger equation with potential in energy space H^(2)(R^(d)).The global well-posedness is obtained in dimensions d≥5 resorting to ...The paper considers the initial value problem of inhomogeneous fourth-order Schr¨odinger equation with potential in energy space H^(2)(R^(d)).The global well-posedness is obtained in dimensions d≥5 resorting to contractive mapping principle,Strichartz estimates,Caffarelli-Kohn-Nirenberg-type inequality and the continuity method.展开更多
The study aimed at predicting potential suitable areas with national key reserve Orchidaceae plants in Heilongjiang province and conducive to plant protection.The distribution point data of six Orchidaceae plants and ...The study aimed at predicting potential suitable areas with national key reserve Orchidaceae plants in Heilongjiang province and conducive to plant protection.The distribution point data of six Orchidaceae plants and 19 bioclimatic variables were selected,and the environmental factors required for modeling were screened out by pearson correlation analysis and variance inflation factor(VIF)analysis.The potential suitable areas of Orchidaceae plants were predictat present and under different climate scenarios in 2090s by using geographic information system(GIS)and Maximum Entropy Model(MaxEnt).And then evaluated the prediction accuracy of the MaxEnt model using the AUC value,the TSS value and the Kappa value.The results showed that:1)The area under curve(AUC)values,true skill statistics(TSS)values and KAPPA values predicted by MaxEnt model were separately above 0.9,0.85 and 0.75.2)Under the climate scenario at present,the total suitable area of Orchidaceae plants was about 9.61×10^(6)km^(2),which was mainly distributed in Heilongjiang province.Among them,the high-suitable area of Cypripedium shanxiense S.C.Chen was the largest,the non-suitable area of Cypripedium guttatum Sw was the largest.3)Under different climate scenarios in 2090s,the total suitable area was slightly increasing(9.62×10^(6)km^(2)).Among them,Cypripedium shanxiense S.C.Chen and Gastrodiae Rhizoma both showed the trend of expansion to the southwest,China,and the suitable areas expanded significantly.Comprehensive factor analysis showed that temperature and precipitation were the main bioclimatic variables of suitable areas distribution,and the low emission scenario(SSP 2-4.5)will be more conducive to the survival of Orchidaceae plants.展开更多
Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China ...Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China in winter and spring of 2021.The results show that the average concentration of PM_(2.5) decreased by 47%from winter to spring,while volume-normalized and mass-normalized OP(i.e.,OP_(v) and OP_(m))increased by 6%and 69%,respectively.It suggests that the decline of PM_(2.5) may not necessarily decrease the health risks and the intrinsic toxicity of PM_(2.5).Variations of OP_(v) and OP_(m) among different periods were related to the different source contributions and environmental conditions.The positive matrix factorization model was used to identify the major sources of OP_(v).OP_(v) was mainly contributed by biomass burning/industrial emissions(29%),soil/road dust(20%),secondary sulfate(14%),and coal combustion(13%)in winter.Different major sources were resolved to be secondary sulfate(36%),biological sources(21%),and marine vessels(20%)in spring,presenting the substantial contribution of biological sources.The analysis shows strong associations between OP_(v) and both live and dead bacteria,further confirming the important contribution of bioaerosols to the enhancement of OP.This study highlights the importance of understanding OP in ambient PM_(2.5) in terms of public health impact and provides a new insight into the biological contribution to OP.展开更多
The high-order deformation effects in even-even^(246,248)No are investigated by means of pairing self-consistent WoodsSaxon-Strutinsky calculations using the potential-energy-surface(PES)approach in an extended deform...The high-order deformation effects in even-even^(246,248)No are investigated by means of pairing self-consistent WoodsSaxon-Strutinsky calculations using the potential-energy-surface(PES)approach in an extended deformation space(β_(2),β_(3),β_(4),β_(5),β_(6),β_(7),β_(8)).Based on the calculated two-dimensional projected energy maps and different potential energy curves,we found that the highly even-order deformations have an important impact on both the fission trajectory and energy minima,while the odd-order deformations,accompanying the even-order ones,primarily affect the fission path beyond the second barrier.Relative to the light actinide nuclei,the nuclear ground state changes to the superdeformed configuration,but the normally deformed minimum,as the low-energy shape isomer,may still be primarily responsible for enhancing nuclear stability and ensuring experimental accessibility in^(246,248)No.Our present investigation indicates the nonnegligible impact of high-order deformation effects along the fission valley and will be helpful for deepening the understanding of different deformation effects and deformation couplings in nuclei,especially in this neutron-deficient heavy-mass region.展开更多
Land use conflicts(LUCs)pose a major challenge to urbanization,and their effective regulation is essential for promoting sustainable regional land use.However,the influence of urban development on conflicts has often ...Land use conflicts(LUCs)pose a major challenge to urbanization,and their effective regulation is essential for promoting sustainable regional land use.However,the influence of urban development on conflicts has often been overlooked.This study developed an index system from three dimensions—agricultural production,residential life,and ecological security—and quantified LUCs in China using spatial statistics and a coupling relationship matrix.It further explored the spatial relationships between conflict types and urban built-up areas(UBA)through accessibility analysis,and applied regression analysis to reveal the spatial evolution of conflicts from an urban-scale perspective.The results showed that agricultural-construction conflicts were concentrated in the eastern plains,while agricultural-ecological conflicts prevailed in the mountainous areas in the western region.Spatial distribution of the distance from conflicts to UBA(DCU)exhibited a clear east-west gradient,being closer in the east(less than 20 km)and farther in the west.Between 2000 and 2020,LUCs moved progressively closer to UBA,except in the ecologically fragile western region.For all urban hierarchies except small cities,the average distance was below 10 km;megacities exhibited the shortest DCU,roughly half that of small cities.Moreover,LUCs displayed significant hierarchical scale effects:as urban size increased,distance tended to decrease in a non-linear pattern,with the steepest decline occurring in central China.Land management authorities should work to curb sprawling urban development.Overall,this study provides new insights into the spatial evolution of LUCs and contributes to more sustainable land use management.展开更多
The published article titled“Truncated Bid Overexpression Induced by Recombinant Adenovirus Cre/LoxP System Suppresses the Tumorigenic Potential of CD133+Ovarian Cancer Stem Cells”has been retracted from Oncology Re...The published article titled“Truncated Bid Overexpression Induced by Recombinant Adenovirus Cre/LoxP System Suppresses the Tumorigenic Potential of CD133+Ovarian Cancer Stem Cells”has been retracted from Oncology Research,Vol.25,No.4,2017,pp.595–603.展开更多
Understanding the complex deformation mechanisms of non-equimolar multi-principal element alloys(MPEAs)requires high-fidelity atomic-scale simulations.This study develops a deep potential(DP)model to enable molecular ...Understanding the complex deformation mechanisms of non-equimolar multi-principal element alloys(MPEAs)requires high-fidelity atomic-scale simulations.This study develops a deep potential(DP)model to enable molecular dynamics simulations of the Ta_(0.4)Ti_(2)Zr(Ta_(0.4))alloy.Monte Carlo simulations using this potential reveal Ta atom precipitation in the Ta_(0.4)alloy.Under uniaxial tensile loading along the[100]direction in the NPT ensemble,the alloy undergoes a remarkable sequence of phase transformations:an initial body-centered cubic(BCC_(1))to face-centered cubic(FCC)transformation,followed by a reverse transformation from FCC to a distinct BCC phase(BCC_(2)),and finally a BCC_(2) to hexagonal close-packed(HCP)transformation.Critically,the reverse FCC to BCC_(2) transformation induces significant volume contraction.We demonstrate that the inversely transformed BCC_(2) phase primarily accommodates compressive stress.Concurrently,the reorientation of BCC_(2) crystals contributes substantially to the observed high strain hardening.These simulations provide atomic-scale insights into the dynamic structural evolution,sequential phase transformations,and stress partitioning during deformation of the Ta_(0.4)alloy.The developed DP model and the revealed mechanisms offer fundamental theoretical guidance for accelerating the design of high-performance MPEAs.展开更多
To understand the transmission paths and potential source areas of fine particulate matter(PM_(2.5))and ozone(O_(3))in Urumqi,using the monitoring data from 2020 to 2022,the pollution characteristics and the transmiss...To understand the transmission paths and potential source areas of fine particulate matter(PM_(2.5))and ozone(O_(3))in Urumqi,using the monitoring data from 2020 to 2022,the pollution characteristics and the transmission paths of PM_(2.5) and O_(3) were studied.Based on the MeteoInfo software,the potential source areas and concentration contributions via the weighted potential source contribution function(WPSCF)and the weighted concentration weighted trajectory(WCWT)were analyzed.Besides,trajectory distribution at different starting heights were compared.The results of the backward trajectory(500 m)showed that the PM_(2.5) and O_(3) clustering trajectories were mainly derived from the northwest and passed through Yining/Ili and Tacheng.The air flow proportion of PM_(2.5) pollution was 44.83%in winter.With the highest pollution concentration(119.2μg/m^(3)),the pollution airflow proportion of O_(3) was 30.52%in summer.According to an analysis of the pressure profile,the atmospheric pressure was below 850 hPa in winter,indicating that the near-surface air mass had a substantial impact on PM_(2.5) concentrations,whereas in summer the pressure for O_(3) rose above 750 hP1,leading to higher pollutant concentrations.The WPSCF/WCWT results of PM_(2.5) demonstrated that the largest potential areas were identified in winter and were mainly distributed in Bozhou,Kuitun,and Shihezi(west of Urumqi,cultivated land/grassland),while the largest potential areas of O_(3) were distributed in Changji(east of Urumqi,barren land)and Turpan(southeast of Urumqi,grassland)in summer.The study indicates that the government should implement stricter measures to control regional transmission and air pollution.展开更多
Explosive cyclones(ECs) are rapidly intensifying subtropical cyclones that can develop within a short time and pose considerable threats to coastal areas in middle and high latitudes.Gaining a comprehensive understand...Explosive cyclones(ECs) are rapidly intensifying subtropical cyclones that can develop within a short time and pose considerable threats to coastal areas in middle and high latitudes.Gaining a comprehensive understanding of their formation,evolution,and mechanisms of explosive development is essential for improving forecasts of extreme weather events and mitigating associated impacts.Potential vorticity(PV),which is closely related to cyclone dynamics,serves as a valuable diagnostic tool in the study of ECs.In this study,two wintertime ECs of differing intensity over the Northwestern Pacific Ocean are analyzed to examine how different atmospheric processes influence PV generation and the rapid development of ECs.The maximum deepening rates of the two ECs are 2.81 Bergeron(called EC1) and 1.52 Bergeron(referred to as EC2).Results indicate that different stages of EC evolution are closely associated with PV tendency changes at different atmospheric levels.Using the PV tendency equation,during the explosive development of EC1,latent heat release may trigger the downward propagation of upper-level PV.For EC2,latent heat release notably enhances low-level PV,directly contributing to its rapid intensification.To validate these findings,sensitivity tests are conducted using the Weather Research and Forecasting model,with latent heat release turned off in the microphysical scheme for both cases.The results confirm the crucial role of latent heat release in generating low-level PV,further revealing that latent heat release contributes more to the explosive development of EC2 than that of EC1.展开更多
The Neogene Shawan Formation in the Chepaizi Uplift of the Junggar Basin(NW China)has obtained high oil flow,demonstrating a good potential for oil and gas exploration.The multi-source hydrocarbon generation backgroun...The Neogene Shawan Formation in the Chepaizi Uplift of the Junggar Basin(NW China)has obtained high oil flow,demonstrating a good potential for oil and gas exploration.The multi-source hydrocarbon generation background and strong tectonic activity have led to the simultaneous production of heavy oil and light oil from multi-layer in the area,which makes it very difficult to identify oil origins,presently,the hot debate on the oil origins needs to be clarified.In this paper,due to the selective consumption of different types of compounds in crude oils by severe and intense biodegradation,the commonly used oilsource correlation tools are ineffective or may produce misleading results,this study adopted a biomarker recovery method based on the principle of mass conservation that uses the sum of the mass of the residual biomarkers and their corresponding biodegradation products to obtain the mass of the original biomarkers,improving the reliability of oil origins determination.Based on the nature and occurrence of crude oils,the investigated oils are subdivided into three types,Group A,Group B and Group C.Group A,light oils occurred mainly in lower structure Neogene Shawan Formation in the western Chepaizi Uplift,while Group B,heavy oils occurred mainly in higher structure Neogene Shawan Formation in the western Chepaizi Uplift.The two types of crude oils may come from the mixed source of Jurassic Badaowan Formation source rocks(J_(1)b)and Paleogene Anjihaihe Formation source rocks(E_(2-3)a)in the Sikeshu Sag,and Jurassic Badaowan Formation source rocks(J_(1)b)are the main source of crude oils.Group C,heavy oils occurred mainly in Neogene Shawan Formation in the eastern Chepaizi Uplift,showing good correlation with the Permian(P_(1)f and P_(2)w)source rocks in the Shawan Sag.At the same time,by combining stable carbon isotope and parameters related to triaromatic steroids,the accuracy of the oilsource correlation results by biomarker recovery method was further verified.展开更多
OBJECTIVE:To examine the differences in cognitive processing between patients with mild cognitive impairment(MCI)of different Traditional Chinese Medicine(TCM)syndrome types to provide evidence supporting the TCM typi...OBJECTIVE:To examine the differences in cognitive processing between patients with mild cognitive impairment(MCI)of different Traditional Chinese Medicine(TCM)syndrome types to provide evidence supporting the TCM typing of MCI.METHODS:Participants were screened using a battery of scales for spleen and kidney deficiency(SKD)/liver Qi stagnation(LQS)-type MCI or those without syndrome or normal control(NC).Following sex,age,and educational matching,behavioral and electroencephalographic data were recorded using the verbal N-back experimental paradigm.The data were then analyzed and compared with respect to the reaction time and correctness of the participants in each group,as well as the amplitude and latency of the event-related potential(ERP)components of P2,N2,and P3.RESULTS:There were no statistically significant differences in the accuracy or reaction times of the behavioral data of the groups.Regarding ERP data,the SKD group had a shorter P2 latency than the LQS and NC groups,while the latter two groups did not differ statistically.The SKD group had a shorter N2 latency than the NC group,while the SKD group did not differ from the LQS group.The SKD and LQS groups had a shorter P3 latency than the NC group.CONCLUSION:Our study offers objective evidence of the distinction between the types of TCM syndrome.Different types of TCM syndromes produce different disease mechanisms,resulting in brain damage with different presentations of cognitive impairment and cognitive processing characteristics.展开更多
BACKGROUND:Although the Confusion Assessment Methods for the Intensive Care Unit(CAMICU) is a recommended tool for diagnosing sepsis-associated encephalopathy(SAE),it has several limitations.Mismatch-negativity(MMN) a...BACKGROUND:Although the Confusion Assessment Methods for the Intensive Care Unit(CAMICU) is a recommended tool for diagnosing sepsis-associated encephalopathy(SAE),it has several limitations.Mismatch-negativity(MMN) and P3a are components of event-related potentials(ERPs) used with electroencephalography(EEG) and are associated with cerebral function changes in critically ill patients.This study aimed to provide a quantitative,non-invasive method to guide SAE diagnosis in nonsedated patients.METHODS:From January 2022 to March 2023,sepsis patients without sedation were enrolled and assessed via the CAM-ICU,Glasgow Coma Scale(GCS),and ERP under standard procedures.Both MMN and P3a data were collected.The diagnostic value of MMN and P3a was assessed with processed ERP data.RESULTS:Thirty-six patients were included in this study,comprising 19 patients with SAE and 17 patients without SAE(NSAE).MMN and P3a amplitudes decreased,and only FzMMN amplitude significantly decreased in SAE patients(2.03 [1.08,2.93] mV vs.3.21 [1.92,4.34] mV,P=0.040).After median dichotomization,low F3P3a and FzP3a amplitudes were associated with higher CAM-ICU positivity rates and APACHE II scores.Both amplitude in F3P3a(AUC=0.710,95%CI:0.527–0.893,P=0.034) and FzP3a(AUC=0.700,95%CI:0.519–0.881,P=0.041) exhibited moderate diagnostic efficacy for SAE,while FzMMN amplitude lacks effective diagnostic value.CONCLUSION:In this pilot study,ERP components F3P3a and FzP3a amplitudes demonstrated moderate diagnostic value for SAE.These exploratory findings require confirmation in larger and powered cohorts.展开更多
Acute presentation of vomiting is a very common presenting complaint in the emergency department(ED).While majority of such complaints can be attributed to benign,self-limiting causes such as gastroenteritis,rarer alt...Acute presentation of vomiting is a very common presenting complaint in the emergency department(ED).While majority of such complaints can be attributed to benign,self-limiting causes such as gastroenteritis,rarer alternative diagnoses should be considered depending on the patient's progress after initial treatment.Here,we present a case of gastric volvulus(GV),a rare but potentially fatal condition that mimics gastroenteritis.展开更多
OBJECTIVE:To explore if Hewei Jiangni granule(和胃降逆颗粒,HWJNG)could regulate esophageal hypersensitivity via stromal interaction molecule 1(STIM1)/transient receptor potential vanilloid subfamily member 1(TRPV1)pat...OBJECTIVE:To explore if Hewei Jiangni granule(和胃降逆颗粒,HWJNG)could regulate esophageal hypersensitivity via stromal interaction molecule 1(STIM1)/transient receptor potential vanilloid subfamily member 1(TRPV1)pathway.METHODS:Qualitative analysis of HWJNG was analysis by high performance of liquid and gas chromatography.In vivo,animal model of non-erosive reflux disease(NERD)was established by fructose intake and restraint stress.HWJNG and Omeprazole were administered by gavage to the drug intervention group.Reflux and visceral hypersensitivity were analyzed by pathological changes,PH value test,mechanical paw withdrawal threshold,thermal withdrawal latency and mast cells(MCs)degranulation.In vitro,substance P(SP)-induced P815 cells and dorsal root ganglion(DRG)cells were cocultured.Expression in both mice and cells of STIM1,TRPV1,and esophageal visceral hypersensitivity-related gastrointestinal neurochemicals were validated by enzyme linked immunosorbent assays,quantitative realtime polymerase chain reaction(qRT-PCR)and Western blot.Moreover,overexpression and small interfering RNA against STIM1 were utilized to verify of the role of HWJNG in DRG cells.RESULTS:HWJNG significantly suppressed intercellular space widening,injury of mitochondrial,MCs degranulation,mechanical allodynia and heat neuropathic sensory and increased pH value of esophageal mucosa in NERD mice.HWJNG inhibited expression of visceral hypersensitivityrelated gastrointestinal neurochemicals in esophageal mucosa and activated P815 cells,and expression of the STIM1,TRPV1 and related neurotransmitters in DRG and DRG cells.STIM1 siRNA and HWJNG both reduced P815 cells adhesion to DRGs cells and Ca2+flow into the cytoplasmic space of DRG cells.Furthermore,HWJNG could reversed STIM1 overexpression induced upregulation of TRPV1.CONCLUSION:HWJNG suppressed intercellular space widening in NERD mice,stabilized MCs and restored neuronal hyperexcitability by regulating visceral hypersensitivity via STIM1/TRPV1 pathway.展开更多
基金funded by the Beijing Municipal Science and Technology Commission [grant number Z221100005222012]the Department of Science and Technology of Hebei Province [grant number 22375404D]+2 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences [grant number XDB0760303]the National Natural Science Foundation of China [grant numbers U2233218 and 42275010]the Open Foundation of the Key Open Laboratory of Urban Meteorology,China Meteorological Administration [grant number LUM-2023-06]。
文摘The enhanced mountain-to-plain convective storms in Beijing on 22 May 2021 were simulated using the highresolution Weather Research and Forecasting model,enabling detailed analyses of convective instability characteristics and underlying causes of stability variations.Generalized potential temperature outperformed traditional potential temperature and equivalent potential temperature in capturing instability variations associated with mid-level latent heating and near-surface evaporative cooling.Local instability variance was primarily governed by potential divergence and the advection of potential instability,with these factors exhibiting out-of-phase distributions.Prior to the onset of heavy precipitation,intense downdrafts transported unstable air from higher levels into more stable regions at lower levels,increasing local near-surface instability,which contributed to the formation of heavy precipitation.During the heavy precipitation stage,vertical divergence between slantwise updrafts and downdrafts in the lowmiddle stable layers led to destabilization,supporting sustained convective development within the precipitation area.At the leading edge of the heavy precipitation,instability enhancement was primarily driven by vertical advection,and less stable air in the lower levels was transported upward,enhancing instability at higher levels.
基金National Natural Science Foundation of China(42575091)Marine Meteorological Science and Data Center Program (2024B1212070014)。
文摘In this study, the ground potential rise(GPR) phenomenon caused by a lightning current injected into a field-shaped artificial grounding grid, as well as the potential difference between two different nodes at the edge of the grounding grid, was observed and analyzed under artificially triggered lightning conditions. Based on circuit theory and measured current data, a π-equivalent circuit was established to simulate the transient response of the grounding grid.Nineteen return strokes from three artificially triggered lightning events were analyzed. The peak currents of the 19 return strokes range from -6.7 to -25.1 kA, and the mean value was -14.3 kA. The GPR decreased rapidly and formed a subpeak after reaching the initial peak, with the mean value of the initial peak being -148.65 kV and the mean value of the subpeak being -92.87 kV. The GPR induced by the triggered lightning currents exhibited a subpeak phenomenon. Simulation results indicate that the subpeak phenomenon is related to localized corrosion of the vertical grounding electrode. The potential difference at the grounding grid edge exhibited a multi-pulse waveform with alternating polarity, dominated by positive pulses. The peak values of both the positive and negative polarity pulses gradually decreased, with the first positive pulse displaying a significantly higher intensity than that of subsequent pulses.
基金supported by the National Natural Science Foundation of China(T2350008)the STI2030-Major Projects[2021ZD0203000(2021ZD0203003)]the Open Research Fund of the State Key Laboratory of Brain-Machine Intelligence,Zhejiang University(BMI2400014).
文摘Addiction,a complex and chronic neurobiological disorder,is characterized by compulsive substance use despite harmful consequences,leading to persistent alterations in brain function,particularly within the reward,motivation,and decision-making systems.Despite the availability of a range of treatment options,including pharmacotherapy and behavioral therapies,relapse remains a major challenge,with many individuals struggling to maintain long-term recovery.Current treatments often show limited efficacy,underscoring the need for novel therapeutic strategies that can address the underlying neurobiological disruptions in addiction.
基金supported by the King Khalid University,Abha,Saudi Arabiathe Deanship of Scientific Research at King Khalid University for funding this work through Large Groups Project under grant number(R.G.P.2/335/46)the Guangdong Office of Research Projects at the Provincial University(No.2024KCXTD064)。
文摘Conjugated microporous polymers(CMPs)are a unique class of organic porous materials characterized byπ-conjugated structures and permanent micropores,distinguishing them from non-porous polymers and conventionalπ-conjugated polymers.CMPs offer extensive versatility in synthetic approaches,enabling the synthesis of cross-linked and mesoporous structures.Advances in chemical processes,structural design,and synthesis methodologies have been developed,resulting in a diverse range of CMPs with unique configurations and properties,contributing to the fast expansion of the field.CMPs are particularly notable for their ability to enable the competitive utilization ofπ-conjugated structures within mesoporous configurations,making them valuable for investigations across various domains.They have shown considerable promise in addressing fuel and environmental challenges,demonstrated by their exceptional performance in applications such as vapor adsorption,heterogeneous catalysis,light emission,light harvesting,and energy generation.This review examines the chemical engineering principles underlying CMPs,including synthesis approaches,systemic research advancements,multifunctional investigations boundaries,potential applications,and progress in synthesis,dimensionality,and morphology studies.Specifically,it offers a comparative analysis of CMPs and linear polymeric materials,aiding in the development of functional polymers.Furthermore,this review explores the primary fundamental limitations of CMPs in fuel-related domains and discusses alternative strategies,including novel synthesis methods incorporating interactions and morphologies,to address these challenges.Ultimately,this assessment aims to provide a valuable and inspiring resource for professionals in the field of fuel management,guiding future research and development efforts.
文摘Adult neurogenesis is generally considered to be very limited;however,there is increasing evidence that this phenomenon is conserved across species.Traditionally,research has focused on identifying precursor cells,those that are actively dividing or have the potential to divide.Direct evidence of adult neurogenesis has been found in rats,mice,songbirds,and nonhuman primates.In humans,while the evidence is indirect,it strongly suggests that neurogenesis also occurs during adulthood.In mammals,this active neurogenesis is preserved by radial glial progenitors,which remain in specific niches in the subventricular zone of the lateral ventricles and in the subgranular zone of the hippocampal dentate gyrus(Kumar et al.,2019).
基金support provided by the Research Grant Office at Sharif University Technology by way of grants G4010902 and QB020105 is gratefully acknowledged.
文摘This study presents a multi-physical modeling approach to analyze the dynamics of moisture potential and stress-deformation features near deep desiccation cracks in clayey soils under three consecutive years’climate variability in an arid region.A triple research approach of statistical analysis,analytical framework,and numerical modeling was used to investigate the complex thermo-hydro-mechanical behavior of desiccation-cracked soil,incorporating realistic climatic data of Qom,Iran.The results revealed the interplay between stress,strain,and pore water pressure over time,demonstrating that soil experiences significant swelling and shrinkage due to cyclic wetting and drying.The horizontal stress distribution shows compressive stress concentration at crack tips during wetting,transitioning to tensile stresses uniformly across the soil surface during drying paths.Similarly,vertical stress distributions exhibit localized compressive stresses along crack boundaries during wetting and tensile stresses during drying,highlighting the critical stress conditions at crack tips.The model differentiates between microstructural and macrostructural changes in porosity.Annual trends in micro-porosity revealed cyclic-dependent behavior,with significant volumetric changes occurring in the first year,stabilizing with successive cycles.The results also indicated that part of the volumetric changes are irreversible,with volumetric plastic strain increasing exponentially but at a decreasing rate over three years.Principal stress analysis indicates a shift from compressive to tensile stress states around cracks,driven by climate-induced wetting and drying cycles.These findings underscore the critical role of climate variability in shaping cracked soil behavior in arid regions,providing insights into the heterogeneous behavior of cracked soil surfFicial layers.
基金Supported by National Natural Science Foundation of China(Grant No.11601122).
文摘The paper considers the initial value problem of inhomogeneous fourth-order Schr¨odinger equation with potential in energy space H^(2)(R^(d)).The global well-posedness is obtained in dimensions d≥5 resorting to contractive mapping principle,Strichartz estimates,Caffarelli-Kohn-Nirenberg-type inequality and the continuity method.
基金funded by Project of Scientific Research Business Expenses of Provincial Scientific Research Institutes in Heilongjiang Province(No.CZKYF2023-1-B024)Heilongjiang Academy of Sciences Dean Fund Project(No.YZ2022ZR02)+1 种基金the Science and Technology Basic Resources Investigation Program of China(No.2019FY100500)the Fundamental Research Funds for the Central Universities(No.2572023CT11).
文摘The study aimed at predicting potential suitable areas with national key reserve Orchidaceae plants in Heilongjiang province and conducive to plant protection.The distribution point data of six Orchidaceae plants and 19 bioclimatic variables were selected,and the environmental factors required for modeling were screened out by pearson correlation analysis and variance inflation factor(VIF)analysis.The potential suitable areas of Orchidaceae plants were predictat present and under different climate scenarios in 2090s by using geographic information system(GIS)and Maximum Entropy Model(MaxEnt).And then evaluated the prediction accuracy of the MaxEnt model using the AUC value,the TSS value and the Kappa value.The results showed that:1)The area under curve(AUC)values,true skill statistics(TSS)values and KAPPA values predicted by MaxEnt model were separately above 0.9,0.85 and 0.75.2)Under the climate scenario at present,the total suitable area of Orchidaceae plants was about 9.61×10^(6)km^(2),which was mainly distributed in Heilongjiang province.Among them,the high-suitable area of Cypripedium shanxiense S.C.Chen was the largest,the non-suitable area of Cypripedium guttatum Sw was the largest.3)Under different climate scenarios in 2090s,the total suitable area was slightly increasing(9.62×10^(6)km^(2)).Among them,Cypripedium shanxiense S.C.Chen and Gastrodiae Rhizoma both showed the trend of expansion to the southwest,China,and the suitable areas expanded significantly.Comprehensive factor analysis showed that temperature and precipitation were the main bioclimatic variables of suitable areas distribution,and the low emission scenario(SSP 2-4.5)will be more conducive to the survival of Orchidaceae plants.
基金supported by the National Natural Science Foundation of China(No.41975156)and the Fundamental Research Funds for the Central Universities.
文摘Oxidative potential(OP)can be used as an indicator of the health risks of particulate matter in the air.To study the variation and sources of OP,we conducted an observation of PM_(2.5) in a megacity in southern China in winter and spring of 2021.The results show that the average concentration of PM_(2.5) decreased by 47%from winter to spring,while volume-normalized and mass-normalized OP(i.e.,OP_(v) and OP_(m))increased by 6%and 69%,respectively.It suggests that the decline of PM_(2.5) may not necessarily decrease the health risks and the intrinsic toxicity of PM_(2.5).Variations of OP_(v) and OP_(m) among different periods were related to the different source contributions and environmental conditions.The positive matrix factorization model was used to identify the major sources of OP_(v).OP_(v) was mainly contributed by biomass burning/industrial emissions(29%),soil/road dust(20%),secondary sulfate(14%),and coal combustion(13%)in winter.Different major sources were resolved to be secondary sulfate(36%),biological sources(21%),and marine vessels(20%)in spring,presenting the substantial contribution of biological sources.The analysis shows strong associations between OP_(v) and both live and dead bacteria,further confirming the important contribution of bioaerosols to the enhancement of OP.This study highlights the importance of understanding OP in ambient PM_(2.5) in terms of public health impact and provides a new insight into the biological contribution to OP.
基金supported by the Natural Science Foundation of Henan Province(No.252300421478)the National Natural Science Foundation of China(Nos.11975209,U2032211,12075287)。
文摘The high-order deformation effects in even-even^(246,248)No are investigated by means of pairing self-consistent WoodsSaxon-Strutinsky calculations using the potential-energy-surface(PES)approach in an extended deformation space(β_(2),β_(3),β_(4),β_(5),β_(6),β_(7),β_(8)).Based on the calculated two-dimensional projected energy maps and different potential energy curves,we found that the highly even-order deformations have an important impact on both the fission trajectory and energy minima,while the odd-order deformations,accompanying the even-order ones,primarily affect the fission path beyond the second barrier.Relative to the light actinide nuclei,the nuclear ground state changes to the superdeformed configuration,but the normally deformed minimum,as the low-energy shape isomer,may still be primarily responsible for enhancing nuclear stability and ensuring experimental accessibility in^(246,248)No.Our present investigation indicates the nonnegligible impact of high-order deformation effects along the fission valley and will be helpful for deepening the understanding of different deformation effects and deformation couplings in nuclei,especially in this neutron-deficient heavy-mass region.
基金National Natural Science Foundation of China,No.72474216。
文摘Land use conflicts(LUCs)pose a major challenge to urbanization,and their effective regulation is essential for promoting sustainable regional land use.However,the influence of urban development on conflicts has often been overlooked.This study developed an index system from three dimensions—agricultural production,residential life,and ecological security—and quantified LUCs in China using spatial statistics and a coupling relationship matrix.It further explored the spatial relationships between conflict types and urban built-up areas(UBA)through accessibility analysis,and applied regression analysis to reveal the spatial evolution of conflicts from an urban-scale perspective.The results showed that agricultural-construction conflicts were concentrated in the eastern plains,while agricultural-ecological conflicts prevailed in the mountainous areas in the western region.Spatial distribution of the distance from conflicts to UBA(DCU)exhibited a clear east-west gradient,being closer in the east(less than 20 km)and farther in the west.Between 2000 and 2020,LUCs moved progressively closer to UBA,except in the ecologically fragile western region.For all urban hierarchies except small cities,the average distance was below 10 km;megacities exhibited the shortest DCU,roughly half that of small cities.Moreover,LUCs displayed significant hierarchical scale effects:as urban size increased,distance tended to decrease in a non-linear pattern,with the steepest decline occurring in central China.Land management authorities should work to curb sprawling urban development.Overall,this study provides new insights into the spatial evolution of LUCs and contributes to more sustainable land use management.
文摘The published article titled“Truncated Bid Overexpression Induced by Recombinant Adenovirus Cre/LoxP System Suppresses the Tumorigenic Potential of CD133+Ovarian Cancer Stem Cells”has been retracted from Oncology Research,Vol.25,No.4,2017,pp.595–603.
基金supported by the National University of Defense Technology Research Fund Projectthe National Natural Science Foundation of China(Grant No.12534013)the Science and Technology Innovation Program of Hunan Province(Grant Nos.2025ZYJ001 and 2021RC4026)。
文摘Understanding the complex deformation mechanisms of non-equimolar multi-principal element alloys(MPEAs)requires high-fidelity atomic-scale simulations.This study develops a deep potential(DP)model to enable molecular dynamics simulations of the Ta_(0.4)Ti_(2)Zr(Ta_(0.4))alloy.Monte Carlo simulations using this potential reveal Ta atom precipitation in the Ta_(0.4)alloy.Under uniaxial tensile loading along the[100]direction in the NPT ensemble,the alloy undergoes a remarkable sequence of phase transformations:an initial body-centered cubic(BCC_(1))to face-centered cubic(FCC)transformation,followed by a reverse transformation from FCC to a distinct BCC phase(BCC_(2)),and finally a BCC_(2) to hexagonal close-packed(HCP)transformation.Critically,the reverse FCC to BCC_(2) transformation induces significant volume contraction.We demonstrate that the inversely transformed BCC_(2) phase primarily accommodates compressive stress.Concurrently,the reorientation of BCC_(2) crystals contributes substantially to the observed high strain hardening.These simulations provide atomic-scale insights into the dynamic structural evolution,sequential phase transformations,and stress partitioning during deformation of the Ta_(0.4)alloy.The developed DP model and the revealed mechanisms offer fundamental theoretical guidance for accelerating the design of high-performance MPEAs.
基金supported by the Central Guiding Local Science and Technology Development Fund Projects(No.236Z4203G)the Science Research Project of Hebei Education Department(No.BJK2024008)+2 种基金Hebei Provincial Graduate Demonstration Course Project and Construction Project(No.KCJSX2022085)Tangshan Municipal Science and Technology Plan-Key Research and Development Plan project(No.22150231J)the Opening Project of Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3)(No.FDLAP20005).
文摘To understand the transmission paths and potential source areas of fine particulate matter(PM_(2.5))and ozone(O_(3))in Urumqi,using the monitoring data from 2020 to 2022,the pollution characteristics and the transmission paths of PM_(2.5) and O_(3) were studied.Based on the MeteoInfo software,the potential source areas and concentration contributions via the weighted potential source contribution function(WPSCF)and the weighted concentration weighted trajectory(WCWT)were analyzed.Besides,trajectory distribution at different starting heights were compared.The results of the backward trajectory(500 m)showed that the PM_(2.5) and O_(3) clustering trajectories were mainly derived from the northwest and passed through Yining/Ili and Tacheng.The air flow proportion of PM_(2.5) pollution was 44.83%in winter.With the highest pollution concentration(119.2μg/m^(3)),the pollution airflow proportion of O_(3) was 30.52%in summer.According to an analysis of the pressure profile,the atmospheric pressure was below 850 hPa in winter,indicating that the near-surface air mass had a substantial impact on PM_(2.5) concentrations,whereas in summer the pressure for O_(3) rose above 750 hP1,leading to higher pollutant concentrations.The WPSCF/WCWT results of PM_(2.5) demonstrated that the largest potential areas were identified in winter and were mainly distributed in Bozhou,Kuitun,and Shihezi(west of Urumqi,cultivated land/grassland),while the largest potential areas of O_(3) were distributed in Changji(east of Urumqi,barren land)and Turpan(southeast of Urumqi,grassland)in summer.The study indicates that the government should implement stricter measures to control regional transmission and air pollution.
基金financially supported by the National Key R&D Program of China (No. 2022YFC3004204)the National Natural Science Foundation of China (No. 42275001)the Natural Science Foundation of Shandong Province (No. ZR2022MD038)。
文摘Explosive cyclones(ECs) are rapidly intensifying subtropical cyclones that can develop within a short time and pose considerable threats to coastal areas in middle and high latitudes.Gaining a comprehensive understanding of their formation,evolution,and mechanisms of explosive development is essential for improving forecasts of extreme weather events and mitigating associated impacts.Potential vorticity(PV),which is closely related to cyclone dynamics,serves as a valuable diagnostic tool in the study of ECs.In this study,two wintertime ECs of differing intensity over the Northwestern Pacific Ocean are analyzed to examine how different atmospheric processes influence PV generation and the rapid development of ECs.The maximum deepening rates of the two ECs are 2.81 Bergeron(called EC1) and 1.52 Bergeron(referred to as EC2).Results indicate that different stages of EC evolution are closely associated with PV tendency changes at different atmospheric levels.Using the PV tendency equation,during the explosive development of EC1,latent heat release may trigger the downward propagation of upper-level PV.For EC2,latent heat release notably enhances low-level PV,directly contributing to its rapid intensification.To validate these findings,sensitivity tests are conducted using the Weather Research and Forecasting model,with latent heat release turned off in the microphysical scheme for both cases.The results confirm the crucial role of latent heat release in generating low-level PV,further revealing that latent heat release contributes more to the explosive development of EC2 than that of EC1.
基金co-funded by the National Natural Science Foundation of China(42372160,42072172)。
文摘The Neogene Shawan Formation in the Chepaizi Uplift of the Junggar Basin(NW China)has obtained high oil flow,demonstrating a good potential for oil and gas exploration.The multi-source hydrocarbon generation background and strong tectonic activity have led to the simultaneous production of heavy oil and light oil from multi-layer in the area,which makes it very difficult to identify oil origins,presently,the hot debate on the oil origins needs to be clarified.In this paper,due to the selective consumption of different types of compounds in crude oils by severe and intense biodegradation,the commonly used oilsource correlation tools are ineffective or may produce misleading results,this study adopted a biomarker recovery method based on the principle of mass conservation that uses the sum of the mass of the residual biomarkers and their corresponding biodegradation products to obtain the mass of the original biomarkers,improving the reliability of oil origins determination.Based on the nature and occurrence of crude oils,the investigated oils are subdivided into three types,Group A,Group B and Group C.Group A,light oils occurred mainly in lower structure Neogene Shawan Formation in the western Chepaizi Uplift,while Group B,heavy oils occurred mainly in higher structure Neogene Shawan Formation in the western Chepaizi Uplift.The two types of crude oils may come from the mixed source of Jurassic Badaowan Formation source rocks(J_(1)b)and Paleogene Anjihaihe Formation source rocks(E_(2-3)a)in the Sikeshu Sag,and Jurassic Badaowan Formation source rocks(J_(1)b)are the main source of crude oils.Group C,heavy oils occurred mainly in Neogene Shawan Formation in the eastern Chepaizi Uplift,showing good correlation with the Permian(P_(1)f and P_(2)w)source rocks in the Shawan Sag.At the same time,by combining stable carbon isotope and parameters related to triaromatic steroids,the accuracy of the oilsource correlation results by biomarker recovery method was further verified.
基金Supported by National Natural Science Foundation of China-funded Project:Study on Mechanism of“Smoothing The Liver Therapy”on Working Memory of the Patients with Mild Cognitive Impairment Caused by Negative Emotion Regulation(No.81473556)Effects and Mechanism of Liver’s Failing to Facilitate the Coursing of Qi on Decline Process of Cognitive Function of Normal People and Patients with MCI(No.81873208)。
文摘OBJECTIVE:To examine the differences in cognitive processing between patients with mild cognitive impairment(MCI)of different Traditional Chinese Medicine(TCM)syndrome types to provide evidence supporting the TCM typing of MCI.METHODS:Participants were screened using a battery of scales for spleen and kidney deficiency(SKD)/liver Qi stagnation(LQS)-type MCI or those without syndrome or normal control(NC).Following sex,age,and educational matching,behavioral and electroencephalographic data were recorded using the verbal N-back experimental paradigm.The data were then analyzed and compared with respect to the reaction time and correctness of the participants in each group,as well as the amplitude and latency of the event-related potential(ERP)components of P2,N2,and P3.RESULTS:There were no statistically significant differences in the accuracy or reaction times of the behavioral data of the groups.Regarding ERP data,the SKD group had a shorter P2 latency than the LQS and NC groups,while the latter two groups did not differ statistically.The SKD group had a shorter N2 latency than the NC group,while the SKD group did not differ from the LQS group.The SKD and LQS groups had a shorter P3 latency than the NC group.CONCLUSION:Our study offers objective evidence of the distinction between the types of TCM syndrome.Different types of TCM syndromes produce different disease mechanisms,resulting in brain damage with different presentations of cognitive impairment and cognitive processing characteristics.
基金supported by the CAMS Innovation Fund for Medical Sciences (CIFMS)(No.2021-1-I2M-020)National High Level Hospital Clinical Research Funding (No.2022-PUMCH-B-109)National Natural Science Foundation of China (82402543)。
文摘BACKGROUND:Although the Confusion Assessment Methods for the Intensive Care Unit(CAMICU) is a recommended tool for diagnosing sepsis-associated encephalopathy(SAE),it has several limitations.Mismatch-negativity(MMN) and P3a are components of event-related potentials(ERPs) used with electroencephalography(EEG) and are associated with cerebral function changes in critically ill patients.This study aimed to provide a quantitative,non-invasive method to guide SAE diagnosis in nonsedated patients.METHODS:From January 2022 to March 2023,sepsis patients without sedation were enrolled and assessed via the CAM-ICU,Glasgow Coma Scale(GCS),and ERP under standard procedures.Both MMN and P3a data were collected.The diagnostic value of MMN and P3a was assessed with processed ERP data.RESULTS:Thirty-six patients were included in this study,comprising 19 patients with SAE and 17 patients without SAE(NSAE).MMN and P3a amplitudes decreased,and only FzMMN amplitude significantly decreased in SAE patients(2.03 [1.08,2.93] mV vs.3.21 [1.92,4.34] mV,P=0.040).After median dichotomization,low F3P3a and FzP3a amplitudes were associated with higher CAM-ICU positivity rates and APACHE II scores.Both amplitude in F3P3a(AUC=0.710,95%CI:0.527–0.893,P=0.034) and FzP3a(AUC=0.700,95%CI:0.519–0.881,P=0.041) exhibited moderate diagnostic efficacy for SAE,while FzMMN amplitude lacks effective diagnostic value.CONCLUSION:In this pilot study,ERP components F3P3a and FzP3a amplitudes demonstrated moderate diagnostic value for SAE.These exploratory findings require confirmation in larger and powered cohorts.
文摘Acute presentation of vomiting is a very common presenting complaint in the emergency department(ED).While majority of such complaints can be attributed to benign,self-limiting causes such as gastroenteritis,rarer alternative diagnoses should be considered depending on the patient's progress after initial treatment.Here,we present a case of gastric volvulus(GV),a rare but potentially fatal condition that mimics gastroenteritis.
基金National Natural Science Foundation of China:Study on the Molecular Mechanism of the Regulation of Crypt Goblet Cell Pyroptosis and Exocytosis to Repair Ulcerative Colitis Mucus Barrier by the Method of Clearing and Opening the Xuanfu from the Perspective of"Xuanfu-Crypt"(No.82305143),and National Natural Science Foundation of China:Exploring the Molecular Mechanism of"Hewei Jiangni Fang"Intervention in Non-erosive Reflux Disease Esophageal Hypersensitivity from the Perspective of Mas-related Gene X2/Stromal Interaction Molecule 1/Cell Adhesion Molecule 1 Pathway Regulation of Mast Cell/Dorsal Root Ganglion Communication based on the"Xinkai-Kujiang"Method(No.82374401)。
文摘OBJECTIVE:To explore if Hewei Jiangni granule(和胃降逆颗粒,HWJNG)could regulate esophageal hypersensitivity via stromal interaction molecule 1(STIM1)/transient receptor potential vanilloid subfamily member 1(TRPV1)pathway.METHODS:Qualitative analysis of HWJNG was analysis by high performance of liquid and gas chromatography.In vivo,animal model of non-erosive reflux disease(NERD)was established by fructose intake and restraint stress.HWJNG and Omeprazole were administered by gavage to the drug intervention group.Reflux and visceral hypersensitivity were analyzed by pathological changes,PH value test,mechanical paw withdrawal threshold,thermal withdrawal latency and mast cells(MCs)degranulation.In vitro,substance P(SP)-induced P815 cells and dorsal root ganglion(DRG)cells were cocultured.Expression in both mice and cells of STIM1,TRPV1,and esophageal visceral hypersensitivity-related gastrointestinal neurochemicals were validated by enzyme linked immunosorbent assays,quantitative realtime polymerase chain reaction(qRT-PCR)and Western blot.Moreover,overexpression and small interfering RNA against STIM1 were utilized to verify of the role of HWJNG in DRG cells.RESULTS:HWJNG significantly suppressed intercellular space widening,injury of mitochondrial,MCs degranulation,mechanical allodynia and heat neuropathic sensory and increased pH value of esophageal mucosa in NERD mice.HWJNG inhibited expression of visceral hypersensitivityrelated gastrointestinal neurochemicals in esophageal mucosa and activated P815 cells,and expression of the STIM1,TRPV1 and related neurotransmitters in DRG and DRG cells.STIM1 siRNA and HWJNG both reduced P815 cells adhesion to DRGs cells and Ca2+flow into the cytoplasmic space of DRG cells.Furthermore,HWJNG could reversed STIM1 overexpression induced upregulation of TRPV1.CONCLUSION:HWJNG suppressed intercellular space widening in NERD mice,stabilized MCs and restored neuronal hyperexcitability by regulating visceral hypersensitivity via STIM1/TRPV1 pathway.
