Background A major public health problem around the world today is mental illness. Although there are several studies on the topic, it is rarely conducted in the context like the current study. Aims This study aims to...Background A major public health problem around the world today is mental illness. Although there are several studies on the topic, it is rarely conducted in the context like the current study. Aims This study aims to find out the attitudes of medical students towards psychiatry and mental illness as a clinical medicine major and evaluate the effects of clinical posting on their attitudes towards psychiatry and mental illness. Methods This is a longitudinal study of 6 months* duration conducted with students in their fifth semester of medical college in Western India during the academic year of 2016-2017. The participants were assessed by pro forma containing demographic details, and the questionnaires—Attitude Towards Psychiatry-30 items (ATP-30) scale and Mental Illness Clinician's Attitude (MICA) scale, which were presented to the students at the beginning and at the end of their psychiatry clinical posting. The statistical analysis was done with GraphPad, InStat V.3.06. A p value <0.05 was considered statistically significant. Results The students' attitudes towards psychiatry were neutral at the beginning of the psychiatry clinical posting, and improved significantly at the end of the posting on both scales: ATP-30 (p=0.002) and MICA (p=0.048). The students became more positive towards the subject and mental illness in general, negative attitudes also reduced but the change was not statistically significant (p=0.058). We found significant improvement in students' thinking towards being a psychiatrist in the future post-term (p=0.0002). The changes in attitude in terms of gender were equivocal, with an increase in positive attitude and reduction in negative attitude post-term in both sexes. Conclusion Psychiatry clinical posting aids in cultivating positive attitude towards psychiatry and mental illness and reduces the stigma associated with the students of this major and psychiatric patients.展开更多
More than ever before, environmental preservation has been a critical issue for the survival of the world’s habitat. An attempt to explore global trends in environmental monitoring using numerous ways based on differ...More than ever before, environmental preservation has been a critical issue for the survival of the world’s habitat. An attempt to explore global trends in environmental monitoring using numerous ways based on different techniques is an exercise in the right direction. This is expedient, given the recent overwhelming growing rate of environmental pollution of advertisement graphical bills worldwide. Posting of advertisement graphical bills constitutes one of the biggest threats to man and his environment as it now appears and as we live in an age of growing sensitivity to environmental cleanliness. Pollution of the Nigerian cities through advertisement bills assumes the general term of outdoor advertising ranging from hand-printed signs, posters, painted bulletins and spectaculars. However this paper discusses the trends of posting graphic advertisement bills in Nigerian cities. Its impact on aesthetics, as well as the pollution problems associated with the urban development. The study areas are Abuja, Akure, Ibadan and Lagos. In order to ensure that each unit of the population is represented, random sampling technique was used to get the necessary information from the samples. The findings emphasize the importance of strict control and market regulations in posting of advertisement bill in built environment and eradication of pollution of the environment.展开更多
Objective:Family medicine,epidemiology,health management and health promotion are the core disciplines of community medicine.In this paper,we discuss the development of a commu-nity posting program within the framewor...Objective:Family medicine,epidemiology,health management and health promotion are the core disciplines of community medicine.In this paper,we discuss the development of a commu-nity posting program within the framework of community medicine core disciplines at a primary health centre attached to a teaching hospital in Puducherry,India.Methods:This is a process documentation of our experience.Results:There were some shortcomings which revolved around the central theme that post-ings were conducted with department in the teaching hospital as the focal point,not the primary health centre(PHC).To address the shortcomings,we made some changes in the existing com-munity posting program in 2013.Student feedback aimed at Kirkpatrick level 1(satisfaction)evaluation revealed that they appreciated the benefits of having the posting with PHC as the focal point.Feedback recommended some further changes in the community posting which could be addressed through complete administrative control of the primary health centre as urban health and training center of the teaching hospital;and also through practice of core disciplines of com-munity medicine by faculty of community medicine.Conclusion:It is important to introduce the medical undergraduates to the core disciplines of community medicine early through community postings.Community postings should be con-ducted with primary health centre or urban health and training centre as the focal point.展开更多
Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the inju...Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the injury and pathophysiological mechanisms underlying PCAS remain unclear.Experimental animal models are valuable tools for exploring the etiology,pathogenesis,and potential interventions for CA and PCAS.Current CA animal models include electrical induction of ventricular fibrillation(VF),myocardial infarction,high potassium,asphyxia,and hemorrhagic shock.Although these models do not fully replicate the complexity of clinical CA,the mechanistic insights they provide remain highly relevant,including post-CA brain injury(PCABI),post-CA myocardial dysfunction(PAMD),systemic ischaemia/reperfusion injury(IRI),and the persistent precipitating pathology.Summarizing the methods of establishing CA models,the challenges encountered in the modeling process,and the mechanisms of PCAS can provide a foundation for developing standardized CA modeling protocols.展开更多
During its millennium of development,the ancient Shu Road system fostered a unique post station culture.In the Qin and Han dynasties,various postal service facilities,termed you,ting,yi,zhi,and si,emerged along the Ba...During its millennium of development,the ancient Shu Road system fostered a unique post station culture.In the Qin and Han dynasties,various postal service facilities,termed you,ting,yi,zhi,and si,emerged along the Baoxie Road,an important segment of the Shu Road system.In the Tang Dynasty,a dense network of post stations was built along the Shu Road.It was during this period that the post stations gained refined names on a substantial scale.Their names were based on the landscapes,resources,histories,and geographical locations of their sites,all of which displayed the characteristics of local gazetteers.During the Tang and Song dynasties,the post stations became large-scale facilities with well-established functions and beautiful environments.The Shu Road post station culture was carried forward in the Ming and Qing dynasties.However,due to frequent warfare and destruction,the Shu Road post station culture was on a declining trajectory during this period.Additionally,the means of transportation exhibited characteristics that varied with time to adapt to the terrain features of the Shu Road system.During the Qin and Han dynasties,transportation was primarily achieved by courier and horse relays.During the Three Kingdoms period,Zhuge Liang devised wooden oxen and gliding horses to transport military supplies and provisions.In the Tang Dynasty,the administration of horses saw remarkable progress,and horses became the primary means of transportation,supplemented by mail coaches.From the Song to the Ming and Qing dynasties,horses,donkeys,and sedans all served as transportation,reflecting the diversity of transportation means in the later periods of imperial China.展开更多
Bio-polyol is considered as a core material to synthesize eco-friendly polyurethane products.However,one of the popular bio-polyols,polytrimethylene ether glycol(PO3G),is reluctant to crystallize and therefore exhibit...Bio-polyol is considered as a core material to synthesize eco-friendly polyurethane products.However,one of the popular bio-polyols,polytrimethylene ether glycol(PO3G),is reluctant to crystallize and therefore exhibits a cold crystallization behavior.This abnormal behavior causes unstable mechanical properties at low-temperature and limits its applications in shape memory devices where crystallization is an essential mechanism.To analyze the unusual phenomenon,we compared different ether polyols focusing on symmetry characteristics and the evenodd effect of carbon backbones.It is found that PO3G has a slow crystallization rate because its ether linkages require specific chain arrangement for attractive interactions.Consequently,a thermal learning mechanism is developed to restore the normal crystallization behavior of elastomers synthesized from the bio-polyol.Repetitive heating and cooling cycles with high-temperature annealing induce urethane exchange reaction and reconstruct the chain orientations for fast crystallization.Results suggest the degree of crystallizations in polyurethane elastomer can be precisely controlled by introducing repetitive thermal treatments to enhance the potential applications of bio-polyols in polymer industries.展开更多
BACKGROUND Elobixibat reportedly improves bowel movements in patients with chronic constipation.However,its effect on bowel movements in elderly patients with chronic constipation in clinical settings has not been exa...BACKGROUND Elobixibat reportedly improves bowel movements in patients with chronic constipation.However,its effect on bowel movements in elderly patients with chronic constipation in clinical settings has not been examined.AIM To examine bowel movement frequency and stool form before and after elobixibat administration in elderly patients with chronic constipation at our clinic.METHODS A total of 10 mg elobixibat was administered to 35(<65 years old)patients and 45(≥65 years old)patients with chronic constipation.The frequency of bowel movements and stool forms,assessed using the Bristol Stool Form Scale(BSFS),were compared between the two groups 1 week before and after elobixibat administration.RESULTS In patients aged<65 years with chronic constipation,the pre-elobixibat frequency of bowel movements and BSFS scores were 2.167±0.732 and 2.286±0.742,respectively.After elobixibat administration,the frequency of bowel movements and BSFS scores improved to 2.389±0.502 and 3.995±0.566,respectively,showing a significant improvement in bowel movement status.In patients aged≥65 years with chronic constipation,the pre-elobixibat frequency of bowel movements and BSFS scores were 2.003±0.733 and 2.217±0.758,respectively.After elobixibat administration,the frequency of bowel movements and BSFS scores improved to 4.402±1.346 and 3.800±0.704,respectively,indicating an improvement in bowel movement status(P<0.001).No significant differences were observed in the frequency and improvement status of bowel movements or BSFS scores between patients with chronic constipation aged≥65 years and<65 years.Adverse events due to the administration of elobixibat occurred in 16 cases(20%).No significant differences were found in the incidence of adverse events between patients with chronic constipation aged<65 years(8 cases,22.9%)and those aged≥65 years(8 cases,17.8%).CONCLUSION Elobixibat is effective in improving bowel movement status in patients with chronic constipation.No significant differences were found in the improvement of bowel movement status or the incidence of adverse events between patients with chronic constipation aged<65 years and≥65 years,suggesting that the drug may be safely used in elderly patients.展开更多
The effects of post heat treatment on the microstructure,aging kinetics,and room/elevated temperature mechanical properties of additively manufactured Inconel 718 superalloy were investigated.Scanning electron microsc...The effects of post heat treatment on the microstructure,aging kinetics,and room/elevated temperature mechanical properties of additively manufactured Inconel 718 superalloy were investigated.Scanning electron microscopy(SEM),electron backscattered diffraction(EBSD),and X-ray diffraction(XRD),as well as hardness,tensile,and creep testing were used for characterization.At temperatures higher than 1100°C,homogenization treatment resulted in the appearance of equiaxed grains by recrystallization and diminishing the dislocation density.The precipitation activation energy for the homogenized and aged condition was obtained as 203.2 kJ/mol,which was higher than the value of~160 kJ/mol for the as-built IN718 superalloy.Therefore,direct aging resulted in a faster aging response,which led to a significant improvement in tensile properties,as rationalized by the strengthening mechanisms.Direct aging treatment resulted in a higher elevated-temperature ultimate tensile strength(UTS)as well as the optimum creep life and the lowest minimum creep rate in comparison with other heat treatment routes,which were attributed to the presence of fine and uniformly dispersed strengthening precipitates in conjunction with the high dislocation density.展开更多
BACKGROUND Military personnel frequently face unique psychological challenges due to highstress environments,which increase the risk of mental health issues like anxiety and depression.Acceptance and commitment therap...BACKGROUND Military personnel frequently face unique psychological challenges due to highstress environments,which increase the risk of mental health issues like anxiety and depression.Acceptance and commitment therapy(ACT)has shown potential in addressing these issues by enhancing psychological flexibility and resilience.AIM To systematically evaluate the effectiveness of ACT in improving the mental health of military personnel.Through a scoping review and meta-analysis,we quantitatively assess the impact of ACT on psychological outcomes,guiding future research and clinical practice.METHODS Relevant literature was searched systematically from database inception to June 30,2023,across multiple databases,including PubMed,Web of Science,Cochrane Library,and Embase.The Joanna Briggs Institute's(JBI)scoping review guidelines were used as the methodological framework.Meta-analysis was performed using a random-effects model,and publication bias was assessed through Egger's regression test and Begg's funnel plot.RESULTS Twenty-six studies were included,highlighting the application of ACT in addressing PTSD,chronic pain,anxiety,and depression among military personnel.The meta-analysis of eight studies demonstrated a significant positive effect of ACT on mental health,with a pooled mean difference of-4.99(95%CI:-6.53 to-3.45).Despite high heterogeneity(I^(2)=63%),sensitivity analyses confirmed the robustness of the findings.CONCLUSION This study underscores the potential of ACT as an effective intervention for improving the mental health of military personnel.Future research should focus on large-scale,multi-center RCTs to further validate these findings,particularly within diverse military populations.展开更多
High-voltage electrical post equipment is generally installed on steel supports,which amplifies the seismic inputs and degrades the seismic performance of equipment.This study proposed a variable cross-section damped ...High-voltage electrical post equipment is generally installed on steel supports,which amplifies the seismic inputs and degrades the seismic performance of equipment.This study proposed a variable cross-section damped steel support frame(VCDFS)with viscous dampers to reduce seismic responses of both tall and low-rise electrical equipment.The VCDFS contains a trapezoidal damper layer to generate rocking motions,enabling the diagonal viscous dampers to dissipate seismic inputs.A theoretical model of post equipment with VCDFS is established,and an optimal design procedure is proposed.The analysis shows that the remaining static stiffness ratio λ_(k) is the key parameter that determines the effectiveness of the VCDFS.The VCDFS reduces the average displacement and stress response of a post insulator by 39.4%and 44.6%,respectively,together with a significant decrease in the dynamic amplification factor.Therefore,it is recommended to use the VCDFS instead of the conventional latticed-steel frame in earthquake zones.展开更多
FIVE decades ago,the establishment of China-EU diplomatic ties signaled a significant shift in the post-war world order.This year,as leaders gathered in Beijing for the 25th China-EU Summit commemorating this mileston...FIVE decades ago,the establishment of China-EU diplomatic ties signaled a significant shift in the post-war world order.This year,as leaders gathered in Beijing for the 25th China-EU Summit commemorating this milestone,they faced a turbulent global landscape marked by geopolitical friction,economic uncertainty,and contested rules.展开更多
Mental health disorders have emerged as a critical global health challenge,profoundly impacting individuals,communities,and societies worldwide.The prevalence of mental health problems has been steadily increasing,wit...Mental health disorders have emerged as a critical global health challenge,profoundly impacting individuals,communities,and societies worldwide.The prevalence of mental health problems has been steadily increasing,with~1 in 8 people,equivalent to 970 million individuals suffering from a mental disorder in 2019(https://vizhub.healthdata.org/gbd-results).Anxiety and depressive disorders are predominant,contributing significantly to the burden of mental health issues,according to the World Health Organization.The COVID-19 pandemic has further exacerbated this situation.It led to a notable upsurge in anxiety and major depressive disorders in 2020.Estimates indicate a 26%rise in anxiety and a 28%increase in depression within that year(https://www.who.int/publications/i/item/WHO-2019-nCoVSci_Brief-Mental_health-2022.1)[1].展开更多
This study analyzed through-thickness distribution of residual stress in a 106 mm ultra-thick TC4 titanium alloy electron beam welded(EBW)joint after post weld heat treatment(PWHT)using X-ray diffraction(XRD)and deep-...This study analyzed through-thickness distribution of residual stress in a 106 mm ultra-thick TC4 titanium alloy electron beam welded(EBW)joint after post weld heat treatment(PWHT)using X-ray diffraction(XRD)and deep-hole drilling(DHD)methods,and investigated the microstructure and mechanical properties.During the PWHT at 600℃,a phase transformation(β→α)occurred in the EBW joint and affected the residual stress distribution and mechanical properties.The surface residual stress was mainly compressive stress,while the internal residual stress was mainly tensile stress in the welded joint.For the as-welded joint,the absolute value of surface residual stress was higher than the absolute value of internal residual stress.After PWHT,the residual stress in the treated joint was substantially reduced compared to the as-welded joint,particularly the surface stress,which relieved from−425 to−90 MPa.However,the residual stress relief effect had minimal positive impact on the internal region at 600℃.PWHT resulted in a shift of the joint fracture location from the fusion zone(FZ)to the base metal(BM),and therefore exerted no noticeable effect on the joint strength,but increased the joint elongation significantly.This study provides valuable insights into the regulation of residual stress distribution of ultra-thick titanium alloy plates.展开更多
Diffusion-bonded Ti_(2)AlNb-based alloys commonly present a low strength compared with the deformed or aged ones. In this study, the post heat treatment including solution and aging treatments is proposed to optimize ...Diffusion-bonded Ti_(2)AlNb-based alloys commonly present a low strength compared with the deformed or aged ones. In this study, the post heat treatment including solution and aging treatments is proposed to optimize the microstructure, contributing to strength improvement and appropriate ductility sacrifice. An available method by the introduction of fine size (both 20-100 nm) and a high fraction (59.7% and 13.7%) of O and α_(2) phases using both solution at 1000℃ for 1 h and aging at 750℃ for 5 h can result in excellent tensile strength (992 MPa and 858 MPa) at room temperature and 650℃, respectively, which increases 5.3% and 44.5% than that of as-received sample. The aging treatment can contribute to lamellar O and α2 grains precipitated from the B_(2) parent, which results in limited dislocation slip systems and slip spaces to resist plastic deformation. Moreover, the crack propagation and fracture surfaces are also comparatively analyzed to reveal the fracture behaviors in the samples with high and low strength. This study can provide a new method for the mechanical property optimization of the welded Ti_(2)AlNb alloys.展开更多
The diagnosis and treatment processes for long COVID have been relatively slow to develop for several reasons,such as a lack of consensus about its definition among medical professionals and researchers,and restricted...The diagnosis and treatment processes for long COVID have been relatively slow to develop for several reasons,such as a lack of consensus about its definition among medical professionals and researchers,and restricted access to knowledge from the relevant pandemics of the past.Legacies of viral pandemics unfortunately do not include sufficient research on how the acute symptoms of infection evolved into chronic health conditions.More so,the idea of surviving a viral pandemic with long-lasting symptoms is not new,yet it is curiously disjointed as a medical concept throughout documented histories on the subject.Individuals with long-term conditions that are rooted in acute viral infections,such as COVID-19,require a coordinated system of care that includes comprehensive rehabilitation.This commentary will discuss the philosophical underpinnings of the historical scarcity of documented incidences of individuals with chronic virus symptoms and the need for a shift in post-viral infection treatment approaches.展开更多
BACKGROUND Historically intraoperative drains were employed after pancreatic surgery but over the last decade,there has been debate over the routine usage of drains.AIM To assess the necessity of intra-abdominal drain...BACKGROUND Historically intraoperative drains were employed after pancreatic surgery but over the last decade,there has been debate over the routine usage of drains.AIM To assess the necessity of intra-abdominal drain placement,identify the most effective drain type,and determine the optimal timing for drain removal.METHODS A systematic review of electronic databases,including PubMed,MEDLINE,PubMed Central,and Google Scholar,was conducted using Medical Subject Headings and keywords until December 2023.From an initial pool of 1910 articles,48 were included after exclusion and screening.The primary outcomes analyzed were clinically relevant postoperative pancreatic fistula(CR-POPF),delayed gastric emptying(DGE),overall morbidity,and mortality.Subgroup analyses were performed for pancreaticoduodenectomy and distal pancreatectomy.RESULTS Routine use of drains is associated with a statistically significant increase in the risk of CR-POPF and DGE.Conversely,patients who did not have drains placed experienced a significant reduction in morbidity,readmission rates,and reoperations.No significant differences were observed between active and passive drain types.Early drain removal(<3 days)yielded favorable outcomes compared to delayed removal.CONCLUSION Analysis of randomized controlled trials and cohort studies did not demonstrate an advantage of routine drain placement following pancreatic resection,potentially contributing to increased morbidity and mortality.The decision to use drains should be left to the discretion of the operating surgeon.However,early drain removal can substantially reduce morbidity.展开更多
Chak-hao,the Forbidden Rice from Manipur,India,is an aromatic,purplish-black rice variety that has been awarded a geographical indication tag to preserve and promote its traditional cultivation in Manipur,India.Althou...Chak-hao,the Forbidden Rice from Manipur,India,is an aromatic,purplish-black rice variety that has been awarded a geographical indication tag to preserve and promote its traditional cultivation in Manipur,India.Although Chak-hao is a hardy landrace with field tolerance to biotic stress,its grains are highly susceptible to storage pest infestations,particularly those caused by the rice weevil(Sitophilus oryzae).This severely compromises its commercial storage quality,as pest damage reduces both nutritional value and quantity.展开更多
文摘Background A major public health problem around the world today is mental illness. Although there are several studies on the topic, it is rarely conducted in the context like the current study. Aims This study aims to find out the attitudes of medical students towards psychiatry and mental illness as a clinical medicine major and evaluate the effects of clinical posting on their attitudes towards psychiatry and mental illness. Methods This is a longitudinal study of 6 months* duration conducted with students in their fifth semester of medical college in Western India during the academic year of 2016-2017. The participants were assessed by pro forma containing demographic details, and the questionnaires—Attitude Towards Psychiatry-30 items (ATP-30) scale and Mental Illness Clinician's Attitude (MICA) scale, which were presented to the students at the beginning and at the end of their psychiatry clinical posting. The statistical analysis was done with GraphPad, InStat V.3.06. A p value <0.05 was considered statistically significant. Results The students' attitudes towards psychiatry were neutral at the beginning of the psychiatry clinical posting, and improved significantly at the end of the posting on both scales: ATP-30 (p=0.002) and MICA (p=0.048). The students became more positive towards the subject and mental illness in general, negative attitudes also reduced but the change was not statistically significant (p=0.058). We found significant improvement in students' thinking towards being a psychiatrist in the future post-term (p=0.0002). The changes in attitude in terms of gender were equivocal, with an increase in positive attitude and reduction in negative attitude post-term in both sexes. Conclusion Psychiatry clinical posting aids in cultivating positive attitude towards psychiatry and mental illness and reduces the stigma associated with the students of this major and psychiatric patients.
文摘More than ever before, environmental preservation has been a critical issue for the survival of the world’s habitat. An attempt to explore global trends in environmental monitoring using numerous ways based on different techniques is an exercise in the right direction. This is expedient, given the recent overwhelming growing rate of environmental pollution of advertisement graphical bills worldwide. Posting of advertisement graphical bills constitutes one of the biggest threats to man and his environment as it now appears and as we live in an age of growing sensitivity to environmental cleanliness. Pollution of the Nigerian cities through advertisement bills assumes the general term of outdoor advertising ranging from hand-printed signs, posters, painted bulletins and spectaculars. However this paper discusses the trends of posting graphic advertisement bills in Nigerian cities. Its impact on aesthetics, as well as the pollution problems associated with the urban development. The study areas are Abuja, Akure, Ibadan and Lagos. In order to ensure that each unit of the population is represented, random sampling technique was used to get the necessary information from the samples. The findings emphasize the importance of strict control and market regulations in posting of advertisement bill in built environment and eradication of pollution of the environment.
文摘Objective:Family medicine,epidemiology,health management and health promotion are the core disciplines of community medicine.In this paper,we discuss the development of a commu-nity posting program within the framework of community medicine core disciplines at a primary health centre attached to a teaching hospital in Puducherry,India.Methods:This is a process documentation of our experience.Results:There were some shortcomings which revolved around the central theme that post-ings were conducted with department in the teaching hospital as the focal point,not the primary health centre(PHC).To address the shortcomings,we made some changes in the existing com-munity posting program in 2013.Student feedback aimed at Kirkpatrick level 1(satisfaction)evaluation revealed that they appreciated the benefits of having the posting with PHC as the focal point.Feedback recommended some further changes in the community posting which could be addressed through complete administrative control of the primary health centre as urban health and training center of the teaching hospital;and also through practice of core disciplines of com-munity medicine by faculty of community medicine.Conclusion:It is important to introduce the medical undergraduates to the core disciplines of community medicine early through community postings.Community postings should be con-ducted with primary health centre or urban health and training centre as the focal point.
基金supported by the National Key Research and Development Program(2021YFC3002205)the Postgraduate Research and Innovation Program of Tianjin Municipal Education Commission(2022BKY113),China.
文摘Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the injury and pathophysiological mechanisms underlying PCAS remain unclear.Experimental animal models are valuable tools for exploring the etiology,pathogenesis,and potential interventions for CA and PCAS.Current CA animal models include electrical induction of ventricular fibrillation(VF),myocardial infarction,high potassium,asphyxia,and hemorrhagic shock.Although these models do not fully replicate the complexity of clinical CA,the mechanistic insights they provide remain highly relevant,including post-CA brain injury(PCABI),post-CA myocardial dysfunction(PAMD),systemic ischaemia/reperfusion injury(IRI),and the persistent precipitating pathology.Summarizing the methods of establishing CA models,the challenges encountered in the modeling process,and the mechanisms of PCAS can provide a foundation for developing standardized CA modeling protocols.
基金This paper is a phased achievement of the project“Organization and Research of the Shu Road Literature”(Project No.17ZDA190),a major project of the National Social Science Fund of China.
文摘During its millennium of development,the ancient Shu Road system fostered a unique post station culture.In the Qin and Han dynasties,various postal service facilities,termed you,ting,yi,zhi,and si,emerged along the Baoxie Road,an important segment of the Shu Road system.In the Tang Dynasty,a dense network of post stations was built along the Shu Road.It was during this period that the post stations gained refined names on a substantial scale.Their names were based on the landscapes,resources,histories,and geographical locations of their sites,all of which displayed the characteristics of local gazetteers.During the Tang and Song dynasties,the post stations became large-scale facilities with well-established functions and beautiful environments.The Shu Road post station culture was carried forward in the Ming and Qing dynasties.However,due to frequent warfare and destruction,the Shu Road post station culture was on a declining trajectory during this period.Additionally,the means of transportation exhibited characteristics that varied with time to adapt to the terrain features of the Shu Road system.During the Qin and Han dynasties,transportation was primarily achieved by courier and horse relays.During the Three Kingdoms period,Zhuge Liang devised wooden oxen and gliding horses to transport military supplies and provisions.In the Tang Dynasty,the administration of horses saw remarkable progress,and horses became the primary means of transportation,supplemented by mail coaches.From the Song to the Ming and Qing dynasties,horses,donkeys,and sedans all served as transportation,reflecting the diversity of transportation means in the later periods of imperial China.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(RS-2024-00451587)supported by Post-plastic Specialized Graduate Program through the Korea Environmental Industry&Technology Institute(KEITI)funded by the Ministry of Environment(MOE).
文摘Bio-polyol is considered as a core material to synthesize eco-friendly polyurethane products.However,one of the popular bio-polyols,polytrimethylene ether glycol(PO3G),is reluctant to crystallize and therefore exhibits a cold crystallization behavior.This abnormal behavior causes unstable mechanical properties at low-temperature and limits its applications in shape memory devices where crystallization is an essential mechanism.To analyze the unusual phenomenon,we compared different ether polyols focusing on symmetry characteristics and the evenodd effect of carbon backbones.It is found that PO3G has a slow crystallization rate because its ether linkages require specific chain arrangement for attractive interactions.Consequently,a thermal learning mechanism is developed to restore the normal crystallization behavior of elastomers synthesized from the bio-polyol.Repetitive heating and cooling cycles with high-temperature annealing induce urethane exchange reaction and reconstruct the chain orientations for fast crystallization.Results suggest the degree of crystallizations in polyurethane elastomer can be precisely controlled by introducing repetitive thermal treatments to enhance the potential applications of bio-polyols in polymer industries.
文摘BACKGROUND Elobixibat reportedly improves bowel movements in patients with chronic constipation.However,its effect on bowel movements in elderly patients with chronic constipation in clinical settings has not been examined.AIM To examine bowel movement frequency and stool form before and after elobixibat administration in elderly patients with chronic constipation at our clinic.METHODS A total of 10 mg elobixibat was administered to 35(<65 years old)patients and 45(≥65 years old)patients with chronic constipation.The frequency of bowel movements and stool forms,assessed using the Bristol Stool Form Scale(BSFS),were compared between the two groups 1 week before and after elobixibat administration.RESULTS In patients aged<65 years with chronic constipation,the pre-elobixibat frequency of bowel movements and BSFS scores were 2.167±0.732 and 2.286±0.742,respectively.After elobixibat administration,the frequency of bowel movements and BSFS scores improved to 2.389±0.502 and 3.995±0.566,respectively,showing a significant improvement in bowel movement status.In patients aged≥65 years with chronic constipation,the pre-elobixibat frequency of bowel movements and BSFS scores were 2.003±0.733 and 2.217±0.758,respectively.After elobixibat administration,the frequency of bowel movements and BSFS scores improved to 4.402±1.346 and 3.800±0.704,respectively,indicating an improvement in bowel movement status(P<0.001).No significant differences were observed in the frequency and improvement status of bowel movements or BSFS scores between patients with chronic constipation aged≥65 years and<65 years.Adverse events due to the administration of elobixibat occurred in 16 cases(20%).No significant differences were found in the incidence of adverse events between patients with chronic constipation aged<65 years(8 cases,22.9%)and those aged≥65 years(8 cases,17.8%).CONCLUSION Elobixibat is effective in improving bowel movement status in patients with chronic constipation.No significant differences were found in the improvement of bowel movement status or the incidence of adverse events between patients with chronic constipation aged<65 years and≥65 years,suggesting that the drug may be safely used in elderly patients.
文摘The effects of post heat treatment on the microstructure,aging kinetics,and room/elevated temperature mechanical properties of additively manufactured Inconel 718 superalloy were investigated.Scanning electron microscopy(SEM),electron backscattered diffraction(EBSD),and X-ray diffraction(XRD),as well as hardness,tensile,and creep testing were used for characterization.At temperatures higher than 1100°C,homogenization treatment resulted in the appearance of equiaxed grains by recrystallization and diminishing the dislocation density.The precipitation activation energy for the homogenized and aged condition was obtained as 203.2 kJ/mol,which was higher than the value of~160 kJ/mol for the as-built IN718 superalloy.Therefore,direct aging resulted in a faster aging response,which led to a significant improvement in tensile properties,as rationalized by the strengthening mechanisms.Direct aging treatment resulted in a higher elevated-temperature ultimate tensile strength(UTS)as well as the optimum creep life and the lowest minimum creep rate in comparison with other heat treatment routes,which were attributed to the presence of fine and uniformly dispersed strengthening precipitates in conjunction with the high dislocation density.
文摘BACKGROUND Military personnel frequently face unique psychological challenges due to highstress environments,which increase the risk of mental health issues like anxiety and depression.Acceptance and commitment therapy(ACT)has shown potential in addressing these issues by enhancing psychological flexibility and resilience.AIM To systematically evaluate the effectiveness of ACT in improving the mental health of military personnel.Through a scoping review and meta-analysis,we quantitatively assess the impact of ACT on psychological outcomes,guiding future research and clinical practice.METHODS Relevant literature was searched systematically from database inception to June 30,2023,across multiple databases,including PubMed,Web of Science,Cochrane Library,and Embase.The Joanna Briggs Institute's(JBI)scoping review guidelines were used as the methodological framework.Meta-analysis was performed using a random-effects model,and publication bias was assessed through Egger's regression test and Begg's funnel plot.RESULTS Twenty-six studies were included,highlighting the application of ACT in addressing PTSD,chronic pain,anxiety,and depression among military personnel.The meta-analysis of eight studies demonstrated a significant positive effect of ACT on mental health,with a pooled mean difference of-4.99(95%CI:-6.53 to-3.45).Despite high heterogeneity(I^(2)=63%),sensitivity analyses confirmed the robustness of the findings.CONCLUSION This study underscores the potential of ACT as an effective intervention for improving the mental health of military personnel.Future research should focus on large-scale,multi-center RCTs to further validate these findings,particularly within diverse military populations.
基金Guangdong Basic and Applied Basic Research Foundation under Grant Nos.2022A1515110561 and 2023A1515010072Natural Science Foundation of China under Grant Nos.52308488 and 52378499。
文摘High-voltage electrical post equipment is generally installed on steel supports,which amplifies the seismic inputs and degrades the seismic performance of equipment.This study proposed a variable cross-section damped steel support frame(VCDFS)with viscous dampers to reduce seismic responses of both tall and low-rise electrical equipment.The VCDFS contains a trapezoidal damper layer to generate rocking motions,enabling the diagonal viscous dampers to dissipate seismic inputs.A theoretical model of post equipment with VCDFS is established,and an optimal design procedure is proposed.The analysis shows that the remaining static stiffness ratio λ_(k) is the key parameter that determines the effectiveness of the VCDFS.The VCDFS reduces the average displacement and stress response of a post insulator by 39.4%and 44.6%,respectively,together with a significant decrease in the dynamic amplification factor.Therefore,it is recommended to use the VCDFS instead of the conventional latticed-steel frame in earthquake zones.
文摘FIVE decades ago,the establishment of China-EU diplomatic ties signaled a significant shift in the post-war world order.This year,as leaders gathered in Beijing for the 25th China-EU Summit commemorating this milestone,they faced a turbulent global landscape marked by geopolitical friction,economic uncertainty,and contested rules.
基金supported by the National Natural Science Foundation of China(T2241028)STI2030-Major Projects[2021ZD0203000(2021ZD0203003)].
文摘Mental health disorders have emerged as a critical global health challenge,profoundly impacting individuals,communities,and societies worldwide.The prevalence of mental health problems has been steadily increasing,with~1 in 8 people,equivalent to 970 million individuals suffering from a mental disorder in 2019(https://vizhub.healthdata.org/gbd-results).Anxiety and depressive disorders are predominant,contributing significantly to the burden of mental health issues,according to the World Health Organization.The COVID-19 pandemic has further exacerbated this situation.It led to a notable upsurge in anxiety and major depressive disorders in 2020.Estimates indicate a 26%rise in anxiety and a 28%increase in depression within that year(https://www.who.int/publications/i/item/WHO-2019-nCoVSci_Brief-Mental_health-2022.1)[1].
基金supported by the National Key Research and Development Program of China(No.2023YFC2810700)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2021193)the Science and Technology Cooperation Project between Jilin Province and Chinese Academy of Sciences(No.2024SYHZ0032).
文摘This study analyzed through-thickness distribution of residual stress in a 106 mm ultra-thick TC4 titanium alloy electron beam welded(EBW)joint after post weld heat treatment(PWHT)using X-ray diffraction(XRD)and deep-hole drilling(DHD)methods,and investigated the microstructure and mechanical properties.During the PWHT at 600℃,a phase transformation(β→α)occurred in the EBW joint and affected the residual stress distribution and mechanical properties.The surface residual stress was mainly compressive stress,while the internal residual stress was mainly tensile stress in the welded joint.For the as-welded joint,the absolute value of surface residual stress was higher than the absolute value of internal residual stress.After PWHT,the residual stress in the treated joint was substantially reduced compared to the as-welded joint,particularly the surface stress,which relieved from−425 to−90 MPa.However,the residual stress relief effect had minimal positive impact on the internal region at 600℃.PWHT resulted in a shift of the joint fracture location from the fusion zone(FZ)to the base metal(BM),and therefore exerted no noticeable effect on the joint strength,but increased the joint elongation significantly.This study provides valuable insights into the regulation of residual stress distribution of ultra-thick titanium alloy plates.
基金support by the National Key R&D Program of China(No.2022YFB3402200)the Program of Shanghai Academic Research Leader(No.22XD1421600).
文摘Diffusion-bonded Ti_(2)AlNb-based alloys commonly present a low strength compared with the deformed or aged ones. In this study, the post heat treatment including solution and aging treatments is proposed to optimize the microstructure, contributing to strength improvement and appropriate ductility sacrifice. An available method by the introduction of fine size (both 20-100 nm) and a high fraction (59.7% and 13.7%) of O and α_(2) phases using both solution at 1000℃ for 1 h and aging at 750℃ for 5 h can result in excellent tensile strength (992 MPa and 858 MPa) at room temperature and 650℃, respectively, which increases 5.3% and 44.5% than that of as-received sample. The aging treatment can contribute to lamellar O and α2 grains precipitated from the B_(2) parent, which results in limited dislocation slip systems and slip spaces to resist plastic deformation. Moreover, the crack propagation and fracture surfaces are also comparatively analyzed to reveal the fracture behaviors in the samples with high and low strength. This study can provide a new method for the mechanical property optimization of the welded Ti_(2)AlNb alloys.
文摘The diagnosis and treatment processes for long COVID have been relatively slow to develop for several reasons,such as a lack of consensus about its definition among medical professionals and researchers,and restricted access to knowledge from the relevant pandemics of the past.Legacies of viral pandemics unfortunately do not include sufficient research on how the acute symptoms of infection evolved into chronic health conditions.More so,the idea of surviving a viral pandemic with long-lasting symptoms is not new,yet it is curiously disjointed as a medical concept throughout documented histories on the subject.Individuals with long-term conditions that are rooted in acute viral infections,such as COVID-19,require a coordinated system of care that includes comprehensive rehabilitation.This commentary will discuss the philosophical underpinnings of the historical scarcity of documented incidences of individuals with chronic virus symptoms and the need for a shift in post-viral infection treatment approaches.
文摘BACKGROUND Historically intraoperative drains were employed after pancreatic surgery but over the last decade,there has been debate over the routine usage of drains.AIM To assess the necessity of intra-abdominal drain placement,identify the most effective drain type,and determine the optimal timing for drain removal.METHODS A systematic review of electronic databases,including PubMed,MEDLINE,PubMed Central,and Google Scholar,was conducted using Medical Subject Headings and keywords until December 2023.From an initial pool of 1910 articles,48 were included after exclusion and screening.The primary outcomes analyzed were clinically relevant postoperative pancreatic fistula(CR-POPF),delayed gastric emptying(DGE),overall morbidity,and mortality.Subgroup analyses were performed for pancreaticoduodenectomy and distal pancreatectomy.RESULTS Routine use of drains is associated with a statistically significant increase in the risk of CR-POPF and DGE.Conversely,patients who did not have drains placed experienced a significant reduction in morbidity,readmission rates,and reoperations.No significant differences were observed between active and passive drain types.Early drain removal(<3 days)yielded favorable outcomes compared to delayed removal.CONCLUSION Analysis of randomized controlled trials and cohort studies did not demonstrate an advantage of routine drain placement following pancreatic resection,potentially contributing to increased morbidity and mortality.The decision to use drains should be left to the discretion of the operating surgeon.However,early drain removal can substantially reduce morbidity.
文摘Chak-hao,the Forbidden Rice from Manipur,India,is an aromatic,purplish-black rice variety that has been awarded a geographical indication tag to preserve and promote its traditional cultivation in Manipur,India.Although Chak-hao is a hardy landrace with field tolerance to biotic stress,its grains are highly susceptible to storage pest infestations,particularly those caused by the rice weevil(Sitophilus oryzae).This severely compromises its commercial storage quality,as pest damage reduces both nutritional value and quantity.
