Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this ...Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this end,we herein develop a portable self-calibrating platform namely carbon dots(C-dots)-embedded hydrogel sensors with a smartphone-assisted high-throughput imaging device,for DOX sensing.The prepared green-emitting(λ_(em)=508 nm)and negatively-charged C-dots(−11.40±1.21 mV),which have sufficient spectral overlap with the absorption band of DOX(∼500 nm),can strongly bind with positively-charged DOX molecules by electrostatic attraction effects.As a result,DOX molecules are selectively and rapid(20 s)determined with a detection limit of 10.26 nmol/L via Förster resonance energy transfer processes,demonstrating a remarkably chromatic shift from green to red.Further integrated with a 3D-printed smartphone-assisted device,the platform enabled high-throughput quantification,achieving recoveries of 96.40%-101.85%in human urine/serum(RSDs<2.94%,n=3).Notably,the dual linear detection ranges of the platform align with the reported clinical DOX concentrations in urine and plasma(0-4 h post-administration),validating their capability for direct quantification of DOX in clinical samples without special pre-treatment processes.By virtue of attractive analytical performances and robust feasibility,this platform bridges laboratory precision and point-of-care testing needs,offering promising potential for personalized chemotherapy and multiplexed analyte screening.展开更多
Clinicians involved in HIV/AIDS （Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome） prevention of mother to child transmission （PMTCT） programme and research activities can benefit from the advantag...Clinicians involved in HIV/AIDS （Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome） prevention of mother to child transmission （PMTCT） programme and research activities can benefit from the advantages that computerized systems add to medical practice even in resource constrained sub-Saharan clinic settings. Their continued use of paper based systems presents clinical data management and patient care challenges. A portable point of care data capture electronic system and a computerized clinic patient management system （CCPMS） were implemented to remedy these challenges. PMTCT report compilation was easier with the portable data collection system whose data were found to be more complete and accurate with a 0.83% error rate compared to a 4.1% error rate in the paper registers. A resounding majority of clinicians preferred using the new CCPMS with many of the view that it improved drug inventory and general clinic management with a positive effect on patient care.展开更多
Background and Objective Electromagnetic navigation technology has demonstrated significant potential in enhancing the accuracy and safety of neurosurgical procedures.However,traditional electromagnetic navigation sys...Background and Objective Electromagnetic navigation technology has demonstrated significant potential in enhancing the accuracy and safety of neurosurgical procedures.However,traditional electromagnetic navigation systems face challenges such as high equipment costs,complex operation,bulky size,and insufficient anti-interference performance.To address these limitations,our study developed and validated a novel portable electromagnetic neuronavigation system designed to improve the precision,accessibility,and clinical applicability of electromagnetic navigation technology in cranial surgery.Methods The software and hardware architecture of a portable neural magnetic navigation system was designed.The key technologies of the system were analysed,including electromagnetic positioning algorithms,miniaturized sensor design,optimization of electromagnetic positioning and navigation algorithms,anti-interference signal processing methods,and fast three-dimensional reconstruction algorithms.A prototype was developed,and its accuracy was tested.Finally,a preliminary clinical application evaluation was conducted.Results This study successfully developed a comprehensive portable electromagnetic neuronavigation system capable of achieving preoperative planning,intraoperative real-time positioning and navigation,and postoperative evaluation of navigation outcomes.Through rigorous collaborative testing of the system’s software and hardware,the accuracy of electromagnetic neuronavigation has been validated to meet clinical requirements.Conclusions This study developed a portable neuroelectromagnetic navigation system and validated its effectiveness and safety through rigorous model testing and preliminary clinical applications.The system is characterized by its compact size,high precision,excellent portability,and user-friendly operation,making it highly valuable for promoting navigation technology and advancing the precision and minimally invasive nature of neurosurgical procedures.展开更多
The multiple nuclides identification algorithm with low consumption and strong robustness is crucial for rapid radioactive source searching.This study investigates the design of a low-consumption multiple nuclides ide...The multiple nuclides identification algorithm with low consumption and strong robustness is crucial for rapid radioactive source searching.This study investigates the design of a low-consumption multiple nuclides identification algorithm for portable gamma spectrometers.First,the gamma spectra of 12 target nuclides(including the background case)were measured to create training datasets.The characteristic energies,obtained through energy calibration and full-energy peak addresses,are utilized as input features for a neural network.A large number of single-and multiple-nuclide training datasets are generated using random combinations and small-range drifting.Subsequently,a multi-label classification neural network based on a binary cross-entropy loss function is applied to export the existence probability of certain nuclides.The designed algorithm effectively reduces the computation time and storage space required by the neural network and has been successfully implemented in a portable gamma spectrometer with a running time of t_(r)<2 s.Results show that,in both validation and actual tests,the identification accuracy of the designed algorithm reaches 94.8%,for gamma spectra with a dose rate of d≈0.5μSv∕h and a measurement time t_(m)=60 s.This improves the ability to perform rapid on-site nuclide identification at important sites.展开更多
Traditional diagnostic tools for depression,such as the Patient Health Questionnaire-9,are susceptible to subjective bias,increasing the risk of misdiagnosis and emphasizing the critical need for objective biomarkers....Traditional diagnostic tools for depression,such as the Patient Health Questionnaire-9,are susceptible to subjective bias,increasing the risk of misdiagnosis and emphasizing the critical need for objective biomarkers.This minireview evaluates the emerging role of portable electroencephalography(EEG)as a cost-effective,accessible solution for early depression detection.By synthesizing findings from 45 studies(selected from 764 screened articles),we highlight EEG’s capacity to identify aberrant neural oscillations associated with core depressive symptoms,including anhedonia,excessive guilt,and persistent low mood.Advances in portable systems demonstrate promising classification accuracy when integrated with machine learning algorithms,with long short-term memory models achieving>90%accuracy in recent trials.However,persistent challenges,such as signal quality variability,motion artifacts,and limited clinical validation,hinder widespread adoption.Further innovation in sensor optimization,multimodal data integration,and real-world clinical trials is essential to translate portable EEG into a reliable diagnostic tool.This minireview underscores the transformative potential of neurotechnology in psychiatry while advocating for rigorous standard ization to bridge the gap between research and clinical practice.展开更多
With the rapid advancement of portable energy devices and sensor technologies,enhancing their catalytic performance,sensing capabilities,and application reliability has become a critical challenge in the fields of mat...With the rapid advancement of portable energy devices and sensor technologies,enhancing their catalytic performance,sensing capabilities,and application reliability has become a critical challenge in the fields of materials and energy science.Single-atom catalysts(SACs),owing to their high atomic utilization,outstanding catalytic activity,and precisely engineered structures enabled by density functional theory and enhanced by artificial intelligence,have shown tremendous potential in advancing portable energy and sensing technologies.While existing reviews predominantly focus on the application of SACs in individual portable devices,systematic discussions on their overall development prospects and challenges within portable energy and sensor fields remain scarce.Therefore,this review comprehensively explores the application potential and recent advancements of SACs in portable zinc-air batteries,proton exchange membrane fuel cells,and sensor technologies.The article highlights the influence of key factors such as material design,structural optimization,and packaging integration on device performance,while also addressing the primary bottlenecks and challenges encountered in current practical applications.Furthermore,it suggests possible future development directions,aiming to offer theoretical insights and engineering guidance for the large-scale deployment of SACs in wearable electronic devices,portable energy systems,and smart sensing technologies.展开更多
BACKGROUND Conventional reusable endoscopes have high disinfection costs because of their large size.In this study,we compared the effectiveness,safety,and operation performance of the portable disposable large-channe...BACKGROUND Conventional reusable endoscopes have high disinfection costs because of their large size.In this study,we compared the effectiveness,safety,and operation performance of the portable disposable large-channel endoscope that we developed with those of a conventional gastroscope in endoscopic submucosal dissection(ESD).AIM To compare two gastroscopes in ESD for effectiveness and safety.METHODS Ten Bama pigs were subjected to gastroscopy and ESD after general anesthesia.The experiment was completed by four experienced endoscopists.First,two endoscopists randomly selected the portable disposable large-channel or conventional gastroscope to complete gastroscopy procedures.The other two endoscopists assessed the quality of endoscopic images.After endoscopy,all of the endoscopists randomly used the portable disposable large-channel endoscope or the conventional gastroscope for ESD.Endoscopic operation performance,submucosal dissection time,total procedure time,total submucosal injection volume,specimen size,success rate of en bloc resection,muscular injury rate,and complications were compared between the endoscopes.RESULTS No significant differences in gastroscopy duration or in the integrity,sharpness,saturation,and brightness of the gastroscopic images were observed between the gastroscopes.For ESD,no significant differences in endoscopic operation performance,incision time,submucosal dissection time,total procedure time,total submucosal injection volume,specimen size,or success rate of en bloc resection were observed between the gastroscopes.Neither gastroscope caused muscular injury or treatment-related complica-tions.CONCLUSION The portable disposable large-channel endoscope can be used safely and effectively for gastroscopy and treatment.展开更多
Lactate,as a metabolite,plays a significant role in a number of fields,including medical diagnostics,exercise physiology and food science.Traditional methods for lactate measurement often involve expensive and cumbers...Lactate,as a metabolite,plays a significant role in a number of fields,including medical diagnostics,exercise physiology and food science.Traditional methods for lactate measurement often involve expensive and cumbersome instrumentation.This study developed a portable and low-cost lactate measurement system,including independently detectable hardware circuits and user-friendly embedded software,computer,and smartphone applications.The experiment verified that the relative error of the detection current in the device circuit was less than 1%.The electrochemical performance was measured by comparing the[Fe(CN)_(6)]^(3−)/[Fe(CN)_(6)]^(4−)solution with the desktop electrochemical workstation CHI660E,and a nearly consistent chronoamperometry(CA)curve was obtained.Two modified lactate sensors were used for CA testing of lactate.Within the concentration range of 0.1 mmol·L^(−1)to 20 mmol·L^(−1),there was a good linear relationship between lactate concentration and steady-state current,with a correlation coefficient(R2)greater than 0.99 and good repeatability,demonstrating the reliability of the developed device.The lactate measurement system developed in this study not only provides excellent detection performance and reliability,but also achieves portability and low cost,providing a new solution for lactate measurement.展开更多
Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant...Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant on traditional laptops and computers, which, while portable, lack true ultra-portability. This paper explores the potential impact of developing a dedicated, ultra-portable, low-cost device for on-the-go penetration testing. Such a device could replicate the core functionalities of advanced penetration testing tools, including those found in Kali Linux, within a compact form factor that fits easily into a pocket. By offering the convenience and portability akin to a smartphone, this innovative device could redefine the way penetration testers operate, enabling them to carry essential tools wherever they go and ensuring they are always prepared to conduct security assessments efficiently. This approach aims to revolutionize penetration testing by merging high functionality with unparalleled portability.展开更多
This paper presents our endeavors in developing the large-scale, ultra-high-resolution E3SM Land Model (uELM), specifically designed for exascale computers furnished with accelerators such as Nvidia GPUs. The uELM is ...This paper presents our endeavors in developing the large-scale, ultra-high-resolution E3SM Land Model (uELM), specifically designed for exascale computers furnished with accelerators such as Nvidia GPUs. The uELM is a sophisticated code that substantially relies on High-Performance Computing (HPC) environments, necessitating particular machine and software configurations. To facilitate community-based uELM developments employing GPUs, we have created a portable, standalone software environment preconfigured with uELM input datasets, simulation cases, and source code. This environment, utilizing Docker, encompasses all essential code, libraries, and system software for uELM development on GPUs. It also features a functional unit test framework and an offline model testbed for comprehensive numerical experiments. From a technical perspective, the paper discusses GPU-ready container generations, uELM code management, and input data distribution across computational platforms. Lastly, the paper demonstrates the use of environment for functional unit testing, end-to-end simulation on CPUs and GPUs, and collaborative code development.展开更多
Methane(CH_(4))is the second greenhouse gas and has a profound impact on global climate change due to its high global warming potential and concentration.By 2022,the CH_(4)concentration was approximately 1.9 ppm,which...Methane(CH_(4))is the second greenhouse gas and has a profound impact on global climate change due to its high global warming potential and concentration.By 2022,the CH_(4)concentration was approximately 1.9 ppm,which was 264%of the pre-industrial level.The spatiotemporal distribution of CH_(4)was investigated by a portable CH_(4)detector on an unmanned aerial vehicle and electric bicycles in Shaoxing,a city situated in the Yangtze River Delta,China.The vertical distribution revealed CH_(4)concentration generally decreased slowly with height.However,the inversion condition and low atmospheric boundary layer height(ABLH)leaded to the enhancement of CH_(4)with height.The highest CH_(4)concentration(2.2±0.1 ppm,n=1428)was observed in winter and the lowest(2.0±0.2 ppm,n=1530)in spring.Regarding the daily variation,CH_(4)concentration peaked at 5:00 local time(LT)and reached its lowest level at 14:00 LT,which was attributed to the daily variation of ABLH,lowest in the early morning and highest in the noon.In urban areas,CH_(4)concentrations showed higher levels near restaurants,natural gas stations and sewerage well,with a maximum value of 13.1 ppm,which was caused by CH_(4)emission and natural gas leakage from these places.The annual CH_(4)emission in Shaoxing were estimated to be approximately 69 ton/(km^(2)·year)by the mass balance approach.Compared with other cities in the world,the CH_(4)emission is in higher level which imply some control measures should be conducted to reduce CH_(4)emission in Shaoxing.展开更多
The long-standing use of portable toilet cubicles by residents of Shanghai’s narrow,labyrinthine alleys came to an end in September 2025 after the city largely finished building public toilets to make up their lack o...The long-standing use of portable toilet cubicles by residents of Shanghai’s narrow,labyrinthine alleys came to an end in September 2025 after the city largely finished building public toilets to make up their lack of sanitation facilities.The project,targeting 14,082 households,started last year.展开更多
With the advances of our society,the application scope of energy storage technologies has expanded dramatically,spanning diverse scenarios.These include electric air vehicles(EAVs)that require instantaneous high-power...With the advances of our society,the application scope of energy storage technologies has expanded dramatically,spanning diverse scenarios.These include electric air vehicles(EAVs)that require instantaneous high-power bursts for takeoff and maneuvering,portable medical devices demanding rapid rechargeability,and grid-connected energy storage systems that must swiftly respond to load fluctuations[1].展开更多
Driven by the increasing demand for high-energy-density batteries in electric vehicles and portable electronics,lithium metal batteries have made significant breakthroughs[1–3].While critical challenges associated wi...Driven by the increasing demand for high-energy-density batteries in electric vehicles and portable electronics,lithium metal batteries have made significant breakthroughs[1–3].While critical challenges associated with lithium metal anodes in liquid electrolytes(e.g.,dendrite growth,interface instability)have hindered commercialization[4–6],solid electrolyte systems have shown promise in mitigating these issues.Among these,solid polymer electrolytes(SPEs)have emerged as a viable solution for enabling stable quasisolid-state lithium metal batteries[7–9].展开更多
Non-road equipment is one of the key contributing sources to air pollution.Thus,an accurate development of emission inventory from non-road equipment is imperative for air quality management,especially for equipment w...Non-road equipment is one of the key contributing sources to air pollution.Thus,an accurate development of emission inventory from non-road equipment is imperative for air quality management,especially for equipment with a large population such as diesel-fueled forklifts.The objective of this paper is to characterize duty-cycle based emissions from diesel-fueled forklifts using a portable emission measurement system(PEMS).Three dutycycles were defined in this study,including idling,moving,and working(active duty operation)and used to characterize in-use emissions for diesel-fueled forklifts.A total of twelve diesel-fueled forklifts were selected for real-world emission measurements.Results showed that fuel-based emission factors appear to have smaller variability compared to time-based ones.For example,the time-based emission factors for CO,HC,NO,and PM 2.5 for forklifts were estimated to be 16.6-43.9,5.3-15.1,26.2-49.9,5.5-11.1 g/hr with the fuel-based emission factors being 12.1-20.3,4.1-8.3,19.1-32.4,3.5-6.5 g/kg-fuel,respectively.NO emissions appear to be the biggest concern for emissions control.Furthermore,most of the emissions factors estimated from this study are significantly different from those in both National Guideline for Emission Inventory Development for Non-Road Equipment in China and welldeveloped emission factor models such as NONROAD by US EPA.This implies that localized,preferably fuel-based emission factors should be adjusted based on real-world emission measurements in order to develop a representative emission inventory for non-road equipment.展开更多
In order to rescue a trapped miner and clean out roadways quickly in a high gas mine shaft after a mining mishap, a special portable cold-cutting equipment is needed, the main technology parameters were calculated acc...In order to rescue a trapped miner and clean out roadways quickly in a high gas mine shaft after a mining mishap, a special portable cold-cutting equipment is needed, the main technology parameters were calculated according to the advanced cold-cutting technology of high pressure abrasive water jet and the portable mixed abrasive water jet equipment （PAWE） was designed to meet the needs of emergency rescue in high gas mine shafts. Tested the PAWE in a high gas environment, and the result shows that the maximum cutting depth of solid iron pipe is 18 mm and the recoilforce of the sprayer is 28.9 N under the conditions that actual cutting pressure is 29 MPa, starting target distance is 10 ram, cutting speed is 180 mm/min and concentration of abrasive is 32%. The course of the experiment in the high gas environment was smooth and continuous, without any explosion. The PAWE is easy to move and operate, but the nozzle which was worn badly in the sprayer should be changed every 8 minutes.展开更多
Biochemistry weapon is raising new tools of war and terror.This research is an experiment about portable system for CWAs (chemical warfare agents) detection using micro array gas system.CWAs were divided into four typ...Biochemistry weapon is raising new tools of war and terror.This research is an experiment about portable system for CWAs (chemical warfare agents) detection using micro array gas system.CWAs were divided into four types such as blood, nerve,vesicant,and choking agent.To detect various CWAs,semiconductor thick film sensor array based on tin oxide was fabricated and their gas responses were examined.Operating temperature was range of 250℃to 350℃and gas concentration was range of 0.1μg/g to 10μg/g.Sensor array was measured as operating temperatures,concentrations for four simulant agents of CWAs.Extracted parameters from results were carried out classification among CWAs through the principal component analysis (PCA).Also,classification of gases is studied using adaptive resonance theory (ART) that is one of neural network algorithm.Results displayed using PDA system.展开更多
A novel electrochemical method for the rapid detection of organophosphorus pesticide residues was realized on a dual-channel screen-printed electrode （DSPE） that was integrated with a portable smartphone-controlled ...A novel electrochemical method for the rapid detection of organophosphorus pesticide residues was realized on a dual-channel screen-printed electrode （DSPE） that was integrated with a portable smartphone-controlled potentiostat. The two carbon working channels of DSPE were first modified by electrodepositing of Prussian blue. The channels were then modified with acetylcholinesterase （ACHE） via Nation. The inhibition ratio of AChE was detected by comparing the electrical current of acetylthiocholine （ATCh） that was catalyzed by the enzyme electrodes with （channel 1） and without （channel 2） organophosphorus pesticide. Inhibition ratios were related with the negative logarithm of the organophosphorus pesticide （trichlorfon, oxamyl, and isocarbophos） concentrations at optimum experimental conditions （pH 6.9 of electrolyte, 0.2V working potential, 2.5μL AChE modification amount, and 15 min inhibition time）. The linear equations were 1%=32.301gC＋ 253.3 （R=0.9750） for isocarbophos, I% = 35.991gC＋ 270.1 （R = 0.9668） for chlorpyrifos, and 1% = 33.701gC＋ 250.5 （R = 0.9606） for trichlorfon. The detection limits were calculated as 10-7 g/mL. Given that the inhibition ratios were only related with pesticide concentration and not with pesticide species, the proposed electrodes and electrometer can rapidly detect universal organophosphorus pesticides and assess pesticide pollution.展开更多
Tibet, which is rich in mineral resources, is a treasure trove for geological explorers. However, prospecting work has been slow, especially in the western part, due to the precipitous terrain, changeable climate and ...Tibet, which is rich in mineral resources, is a treasure trove for geological explorers. However, prospecting work has been slow, especially in the western part, due to the precipitous terrain, changeable climate and low access. Hence, modern advanced field analytical technology and effective data processing methods play significant roles in rapid and efficient exploration in Tibet. In this paper, spectrum-area fractal modeling and portable X-ray fluorescence analysis(pXRFA) were used to identify and verify geochemical anomalies associated with Ag-Pb-Zn mineralization based on a stream-sediment dataset of 39 elements in the Dajiacuo-Xurucuo region of western Tibet. First, staged factor analysis(SFA) was used to obtain the Ag-Pb-Zn-Cd geochemical assemblage. Second, the first-factor pattern obtained using SFA was dissociated by a spectrum-area(S-A) fractal model and a digital elevation model(DEM)-based geochemical model(DGM) was constructed. Finally, the sections of Ag, Cd, Pb, and Zn were obtained using pXRFA. The results show that Ag-Pb-Zn-Cd enrichment zones were mostly located around the contact belt of volcanic rocks and intrusions, or along SE-NW trending faults. Considering the variable terrain and catchment basin, the extension of long axes of Ag-Pb-Zn-Cd anomalies into higher elevation areas that are favorable for Ag-Pb-Zn mineralization should be investigated. Anomaly maps created with the aid of a DGM show promising potential for mineralization in the Dajiacuo-Xurucuo region, and abundant Ag-Pb-Zn mineralization was identified with the assistance of pXRFA in the source areas for the geochemical anomalies in the Dajiacuo. We conclude that SFA and the S-A fractal model constitute a valid tool to identify or verify geochemical anomalies in areas of low-density stream-sediment sampling. The pXRFA can accurately determine the source of geochemical anomalies and improve anomaly verification efficiency.展开更多
For a portable structured light system,it must be easy to use and fiexible.So the inconvenient and expensive equipment for calibration such as two or three orthogonal planes or extra fixed equipment should not be cons...For a portable structured light system,it must be easy to use and fiexible.So the inconvenient and expensive equipment for calibration such as two or three orthogonal planes or extra fixed equipment should not be considered.For the purpose of fast 3D acquisition,the projection matrices of a portable structured light system should be estimated.This paper proposes a flexible calibration method to meet the requirements of the portable structured light system through a surface plane.A calibration board is attached to the surface plane,and a reference pattern is also projected by an LCD projector onto the surface plane.The camera observes the surface plane at a few different positions.Then,the world-to-image point pairs for the camera and projector are obtained based on the cross ratio and epipolar geometry,and the system is thus calibrated.The experiments conducted for the proposed calibration method demonstrate its accuracy and robustness.展开更多
基金supported by the National NaturalScience Foundation of China(No.22274001)the Key Project of Natural Science Research of the Education Department of Anhui Province(No.2022AH051032)the Excellent Research and Innovation Team of Universities in Anhui Province(No.2024AH010016).
文摘Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this end,we herein develop a portable self-calibrating platform namely carbon dots(C-dots)-embedded hydrogel sensors with a smartphone-assisted high-throughput imaging device,for DOX sensing.The prepared green-emitting(λ_(em)=508 nm)and negatively-charged C-dots(−11.40±1.21 mV),which have sufficient spectral overlap with the absorption band of DOX(∼500 nm),can strongly bind with positively-charged DOX molecules by electrostatic attraction effects.As a result,DOX molecules are selectively and rapid(20 s)determined with a detection limit of 10.26 nmol/L via Förster resonance energy transfer processes,demonstrating a remarkably chromatic shift from green to red.Further integrated with a 3D-printed smartphone-assisted device,the platform enabled high-throughput quantification,achieving recoveries of 96.40%-101.85%in human urine/serum(RSDs<2.94%,n=3).Notably,the dual linear detection ranges of the platform align with the reported clinical DOX concentrations in urine and plasma(0-4 h post-administration),validating their capability for direct quantification of DOX in clinical samples without special pre-treatment processes.By virtue of attractive analytical performances and robust feasibility,this platform bridges laboratory precision and point-of-care testing needs,offering promising potential for personalized chemotherapy and multiplexed analyte screening.
文摘Clinicians involved in HIV/AIDS （Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome） prevention of mother to child transmission （PMTCT） programme and research activities can benefit from the advantages that computerized systems add to medical practice even in resource constrained sub-Saharan clinic settings. Their continued use of paper based systems presents clinical data management and patient care challenges. A portable point of care data capture electronic system and a computerized clinic patient management system （CCPMS） were implemented to remedy these challenges. PMTCT report compilation was easier with the portable data collection system whose data were found to be more complete and accurate with a 0.83% error rate compared to a 4.1% error rate in the paper registers. A resounding majority of clinicians preferred using the new CCPMS with many of the view that it improved drug inventory and general clinic management with a positive effect on patient care.
基金funded by National Natural Science Foundation of China(No.82272134)Innovative Research Group Project of the National Natural Science Foundation of China(No.82272134,Xiao-lei Chen).
文摘Background and Objective Electromagnetic navigation technology has demonstrated significant potential in enhancing the accuracy and safety of neurosurgical procedures.However,traditional electromagnetic navigation systems face challenges such as high equipment costs,complex operation,bulky size,and insufficient anti-interference performance.To address these limitations,our study developed and validated a novel portable electromagnetic neuronavigation system designed to improve the precision,accessibility,and clinical applicability of electromagnetic navigation technology in cranial surgery.Methods The software and hardware architecture of a portable neural magnetic navigation system was designed.The key technologies of the system were analysed,including electromagnetic positioning algorithms,miniaturized sensor design,optimization of electromagnetic positioning and navigation algorithms,anti-interference signal processing methods,and fast three-dimensional reconstruction algorithms.A prototype was developed,and its accuracy was tested.Finally,a preliminary clinical application evaluation was conducted.Results This study successfully developed a comprehensive portable electromagnetic neuronavigation system capable of achieving preoperative planning,intraoperative real-time positioning and navigation,and postoperative evaluation of navigation outcomes.Through rigorous collaborative testing of the system’s software and hardware,the accuracy of electromagnetic neuronavigation has been validated to meet clinical requirements.Conclusions This study developed a portable neuroelectromagnetic navigation system and validated its effectiveness and safety through rigorous model testing and preliminary clinical applications.The system is characterized by its compact size,high precision,excellent portability,and user-friendly operation,making it highly valuable for promoting navigation technology and advancing the precision and minimally invasive nature of neurosurgical procedures.
文摘The multiple nuclides identification algorithm with low consumption and strong robustness is crucial for rapid radioactive source searching.This study investigates the design of a low-consumption multiple nuclides identification algorithm for portable gamma spectrometers.First,the gamma spectra of 12 target nuclides(including the background case)were measured to create training datasets.The characteristic energies,obtained through energy calibration and full-energy peak addresses,are utilized as input features for a neural network.A large number of single-and multiple-nuclide training datasets are generated using random combinations and small-range drifting.Subsequently,a multi-label classification neural network based on a binary cross-entropy loss function is applied to export the existence probability of certain nuclides.The designed algorithm effectively reduces the computation time and storage space required by the neural network and has been successfully implemented in a portable gamma spectrometer with a running time of t_(r)<2 s.Results show that,in both validation and actual tests,the identification accuracy of the designed algorithm reaches 94.8%,for gamma spectra with a dose rate of d≈0.5μSv∕h and a measurement time t_(m)=60 s.This improves the ability to perform rapid on-site nuclide identification at important sites.
基金Supported by Ministry of Science and Technology of the People’s Republic of China-Major Projects,No.2022ZD0212400National Natural Science Foundation of China,No.82371453.
文摘Traditional diagnostic tools for depression,such as the Patient Health Questionnaire-9,are susceptible to subjective bias,increasing the risk of misdiagnosis and emphasizing the critical need for objective biomarkers.This minireview evaluates the emerging role of portable electroencephalography(EEG)as a cost-effective,accessible solution for early depression detection.By synthesizing findings from 45 studies(selected from 764 screened articles),we highlight EEG’s capacity to identify aberrant neural oscillations associated with core depressive symptoms,including anhedonia,excessive guilt,and persistent low mood.Advances in portable systems demonstrate promising classification accuracy when integrated with machine learning algorithms,with long short-term memory models achieving>90%accuracy in recent trials.However,persistent challenges,such as signal quality variability,motion artifacts,and limited clinical validation,hinder widespread adoption.Further innovation in sensor optimization,multimodal data integration,and real-world clinical trials is essential to translate portable EEG into a reliable diagnostic tool.This minireview underscores the transformative potential of neurotechnology in psychiatry while advocating for rigorous standard ization to bridge the gap between research and clinical practice.
文摘With the rapid advancement of portable energy devices and sensor technologies,enhancing their catalytic performance,sensing capabilities,and application reliability has become a critical challenge in the fields of materials and energy science.Single-atom catalysts(SACs),owing to their high atomic utilization,outstanding catalytic activity,and precisely engineered structures enabled by density functional theory and enhanced by artificial intelligence,have shown tremendous potential in advancing portable energy and sensing technologies.While existing reviews predominantly focus on the application of SACs in individual portable devices,systematic discussions on their overall development prospects and challenges within portable energy and sensor fields remain scarce.Therefore,this review comprehensively explores the application potential and recent advancements of SACs in portable zinc-air batteries,proton exchange membrane fuel cells,and sensor technologies.The article highlights the influence of key factors such as material design,structural optimization,and packaging integration on device performance,while also addressing the primary bottlenecks and challenges encountered in current practical applications.Furthermore,it suggests possible future development directions,aiming to offer theoretical insights and engineering guidance for the large-scale deployment of SACs in wearable electronic devices,portable energy systems,and smart sensing technologies.
文摘BACKGROUND Conventional reusable endoscopes have high disinfection costs because of their large size.In this study,we compared the effectiveness,safety,and operation performance of the portable disposable large-channel endoscope that we developed with those of a conventional gastroscope in endoscopic submucosal dissection(ESD).AIM To compare two gastroscopes in ESD for effectiveness and safety.METHODS Ten Bama pigs were subjected to gastroscopy and ESD after general anesthesia.The experiment was completed by four experienced endoscopists.First,two endoscopists randomly selected the portable disposable large-channel or conventional gastroscope to complete gastroscopy procedures.The other two endoscopists assessed the quality of endoscopic images.After endoscopy,all of the endoscopists randomly used the portable disposable large-channel endoscope or the conventional gastroscope for ESD.Endoscopic operation performance,submucosal dissection time,total procedure time,total submucosal injection volume,specimen size,success rate of en bloc resection,muscular injury rate,and complications were compared between the endoscopes.RESULTS No significant differences in gastroscopy duration or in the integrity,sharpness,saturation,and brightness of the gastroscopic images were observed between the gastroscopes.For ESD,no significant differences in endoscopic operation performance,incision time,submucosal dissection time,total procedure time,total submucosal injection volume,specimen size,or success rate of en bloc resection were observed between the gastroscopes.Neither gastroscope caused muscular injury or treatment-related complica-tions.CONCLUSION The portable disposable large-channel endoscope can be used safely and effectively for gastroscopy and treatment.
基金supported by National Natural Science Foundation of China(No.62006092)Natural Science Research Project of Anhui Educational Committee(No.2023AH030081)+1 种基金2023 New Era Education Provincial Quality Engineering Project(Graduate Education)(No.2023cxcysj103)2024 New Era Education Provincial Quality Engineering Project(Graduate Education)。
文摘Lactate,as a metabolite,plays a significant role in a number of fields,including medical diagnostics,exercise physiology and food science.Traditional methods for lactate measurement often involve expensive and cumbersome instrumentation.This study developed a portable and low-cost lactate measurement system,including independently detectable hardware circuits and user-friendly embedded software,computer,and smartphone applications.The experiment verified that the relative error of the detection current in the device circuit was less than 1%.The electrochemical performance was measured by comparing the[Fe(CN)_(6)]^(3−)/[Fe(CN)_(6)]^(4−)solution with the desktop electrochemical workstation CHI660E,and a nearly consistent chronoamperometry(CA)curve was obtained.Two modified lactate sensors were used for CA testing of lactate.Within the concentration range of 0.1 mmol·L^(−1)to 20 mmol·L^(−1),there was a good linear relationship between lactate concentration and steady-state current,with a correlation coefficient(R2)greater than 0.99 and good repeatability,demonstrating the reliability of the developed device.The lactate measurement system developed in this study not only provides excellent detection performance and reliability,but also achieves portability and low cost,providing a new solution for lactate measurement.
文摘Penetration testing plays a critical role in ensuring security in an increasingly interconnected world. Despite advancements in technology leading to smaller, more portable devices, penetration testing remains reliant on traditional laptops and computers, which, while portable, lack true ultra-portability. This paper explores the potential impact of developing a dedicated, ultra-portable, low-cost device for on-the-go penetration testing. Such a device could replicate the core functionalities of advanced penetration testing tools, including those found in Kali Linux, within a compact form factor that fits easily into a pocket. By offering the convenience and portability akin to a smartphone, this innovative device could redefine the way penetration testers operate, enabling them to carry essential tools wherever they go and ensuring they are always prepared to conduct security assessments efficiently. This approach aims to revolutionize penetration testing by merging high functionality with unparalleled portability.
文摘This paper presents our endeavors in developing the large-scale, ultra-high-resolution E3SM Land Model (uELM), specifically designed for exascale computers furnished with accelerators such as Nvidia GPUs. The uELM is a sophisticated code that substantially relies on High-Performance Computing (HPC) environments, necessitating particular machine and software configurations. To facilitate community-based uELM developments employing GPUs, we have created a portable, standalone software environment preconfigured with uELM input datasets, simulation cases, and source code. This environment, utilizing Docker, encompasses all essential code, libraries, and system software for uELM development on GPUs. It also features a functional unit test framework and an offline model testbed for comprehensive numerical experiments. From a technical perspective, the paper discusses GPU-ready container generations, uELM code management, and input data distribution across computational platforms. Lastly, the paper demonstrates the use of environment for functional unit testing, end-to-end simulation on CPUs and GPUs, and collaborative code development.
基金supported by the National Natural Science Foundation of China(No.42327806)the National Key R&D Program of China(No.2022YFC3703500)+4 种基金Zhejiang Province“Lingyan”Research and Development Project(No.2022C03073)Zhejiang Provincial Natural Science Foundation of China(No.LQ23B070009)China Postdoctoral Science Foundation(No.2023M743763)Zhejiang Provincial Postdoctoral Research Excellence Funding Project(No.ZJ2023144)Shaoxing Science and Technology Plan Project(No.2022B41006).
文摘Methane(CH_(4))is the second greenhouse gas and has a profound impact on global climate change due to its high global warming potential and concentration.By 2022,the CH_(4)concentration was approximately 1.9 ppm,which was 264%of the pre-industrial level.The spatiotemporal distribution of CH_(4)was investigated by a portable CH_(4)detector on an unmanned aerial vehicle and electric bicycles in Shaoxing,a city situated in the Yangtze River Delta,China.The vertical distribution revealed CH_(4)concentration generally decreased slowly with height.However,the inversion condition and low atmospheric boundary layer height(ABLH)leaded to the enhancement of CH_(4)with height.The highest CH_(4)concentration(2.2±0.1 ppm,n=1428)was observed in winter and the lowest(2.0±0.2 ppm,n=1530)in spring.Regarding the daily variation,CH_(4)concentration peaked at 5:00 local time(LT)and reached its lowest level at 14:00 LT,which was attributed to the daily variation of ABLH,lowest in the early morning and highest in the noon.In urban areas,CH_(4)concentrations showed higher levels near restaurants,natural gas stations and sewerage well,with a maximum value of 13.1 ppm,which was caused by CH_(4)emission and natural gas leakage from these places.The annual CH_(4)emission in Shaoxing were estimated to be approximately 69 ton/(km^(2)·year)by the mass balance approach.Compared with other cities in the world,the CH_(4)emission is in higher level which imply some control measures should be conducted to reduce CH_(4)emission in Shaoxing.
文摘The long-standing use of portable toilet cubicles by residents of Shanghai’s narrow,labyrinthine alleys came to an end in September 2025 after the city largely finished building public toilets to make up their lack of sanitation facilities.The project,targeting 14,082 households,started last year.
文摘With the advances of our society,the application scope of energy storage technologies has expanded dramatically,spanning diverse scenarios.These include electric air vehicles(EAVs)that require instantaneous high-power bursts for takeoff and maneuvering,portable medical devices demanding rapid rechargeability,and grid-connected energy storage systems that must swiftly respond to load fluctuations[1].
基金supported by the National Natural Science Foundation of China(22279028,21975063,22421001)the Natural Science Foundation of Hebei Province(B2021205019)the 333 Project of Hebei Province(C20231106)。
文摘Driven by the increasing demand for high-energy-density batteries in electric vehicles and portable electronics,lithium metal batteries have made significant breakthroughs[1–3].While critical challenges associated with lithium metal anodes in liquid electrolytes(e.g.,dendrite growth,interface instability)have hindered commercialization[4–6],solid electrolyte systems have shown promise in mitigating these issues.Among these,solid polymer electrolytes(SPEs)have emerged as a viable solution for enabling stable quasisolid-state lithium metal batteries[7–9].
文摘Non-road equipment is one of the key contributing sources to air pollution.Thus,an accurate development of emission inventory from non-road equipment is imperative for air quality management,especially for equipment with a large population such as diesel-fueled forklifts.The objective of this paper is to characterize duty-cycle based emissions from diesel-fueled forklifts using a portable emission measurement system(PEMS).Three dutycycles were defined in this study,including idling,moving,and working(active duty operation)and used to characterize in-use emissions for diesel-fueled forklifts.A total of twelve diesel-fueled forklifts were selected for real-world emission measurements.Results showed that fuel-based emission factors appear to have smaller variability compared to time-based ones.For example,the time-based emission factors for CO,HC,NO,and PM 2.5 for forklifts were estimated to be 16.6-43.9,5.3-15.1,26.2-49.9,5.5-11.1 g/hr with the fuel-based emission factors being 12.1-20.3,4.1-8.3,19.1-32.4,3.5-6.5 g/kg-fuel,respectively.NO emissions appear to be the biggest concern for emissions control.Furthermore,most of the emissions factors estimated from this study are significantly different from those in both National Guideline for Emission Inventory Development for Non-Road Equipment in China and welldeveloped emission factor models such as NONROAD by US EPA.This implies that localized,preferably fuel-based emission factors should be adjusted based on real-world emission measurements in order to develop a representative emission inventory for non-road equipment.
文摘In order to rescue a trapped miner and clean out roadways quickly in a high gas mine shaft after a mining mishap, a special portable cold-cutting equipment is needed, the main technology parameters were calculated according to the advanced cold-cutting technology of high pressure abrasive water jet and the portable mixed abrasive water jet equipment （PAWE） was designed to meet the needs of emergency rescue in high gas mine shafts. Tested the PAWE in a high gas environment, and the result shows that the maximum cutting depth of solid iron pipe is 18 mm and the recoilforce of the sprayer is 28.9 N under the conditions that actual cutting pressure is 29 MPa, starting target distance is 10 ram, cutting speed is 180 mm/min and concentration of abrasive is 32%. The course of the experiment in the high gas environment was smooth and continuous, without any explosion. The PAWE is easy to move and operate, but the nozzle which was worn badly in the sprayer should be changed every 8 minutes.
文摘Biochemistry weapon is raising new tools of war and terror.This research is an experiment about portable system for CWAs (chemical warfare agents) detection using micro array gas system.CWAs were divided into four types such as blood, nerve,vesicant,and choking agent.To detect various CWAs,semiconductor thick film sensor array based on tin oxide was fabricated and their gas responses were examined.Operating temperature was range of 250℃to 350℃and gas concentration was range of 0.1μg/g to 10μg/g.Sensor array was measured as operating temperatures,concentrations for four simulant agents of CWAs.Extracted parameters from results were carried out classification among CWAs through the principal component analysis (PCA).Also,classification of gases is studied using adaptive resonance theory (ART) that is one of neural network algorithm.Results displayed using PDA system.
基金financially supported by the Natural Science Foundation of Zhejiang Province(No.LQ17B050002)Analysis and Measurement Foundation of Zhejiang Province(No.2015C37068)
文摘A novel electrochemical method for the rapid detection of organophosphorus pesticide residues was realized on a dual-channel screen-printed electrode （DSPE） that was integrated with a portable smartphone-controlled potentiostat. The two carbon working channels of DSPE were first modified by electrodepositing of Prussian blue. The channels were then modified with acetylcholinesterase （ACHE） via Nation. The inhibition ratio of AChE was detected by comparing the electrical current of acetylthiocholine （ATCh） that was catalyzed by the enzyme electrodes with （channel 1） and without （channel 2） organophosphorus pesticide. Inhibition ratios were related with the negative logarithm of the organophosphorus pesticide （trichlorfon, oxamyl, and isocarbophos） concentrations at optimum experimental conditions （pH 6.9 of electrolyte, 0.2V working potential, 2.5μL AChE modification amount, and 15 min inhibition time）. The linear equations were 1%=32.301gC＋ 253.3 （R=0.9750） for isocarbophos, I% = 35.991gC＋ 270.1 （R = 0.9668） for chlorpyrifos, and 1% = 33.701gC＋ 250.5 （R = 0.9606） for trichlorfon. The detection limits were calculated as 10-7 g/mL. Given that the inhibition ratios were only related with pesticide concentration and not with pesticide species, the proposed electrodes and electrometer can rapidly detect universal organophosphorus pesticides and assess pesticide pollution.
基金funded by the Fundamental Research Funds for the Central UniversitiesChina University of Geosciences (Wuhan)(No. 2019132)China Geological Survey (No. DD20190159-33)。
文摘Tibet, which is rich in mineral resources, is a treasure trove for geological explorers. However, prospecting work has been slow, especially in the western part, due to the precipitous terrain, changeable climate and low access. Hence, modern advanced field analytical technology and effective data processing methods play significant roles in rapid and efficient exploration in Tibet. In this paper, spectrum-area fractal modeling and portable X-ray fluorescence analysis(pXRFA) were used to identify and verify geochemical anomalies associated with Ag-Pb-Zn mineralization based on a stream-sediment dataset of 39 elements in the Dajiacuo-Xurucuo region of western Tibet. First, staged factor analysis(SFA) was used to obtain the Ag-Pb-Zn-Cd geochemical assemblage. Second, the first-factor pattern obtained using SFA was dissociated by a spectrum-area(S-A) fractal model and a digital elevation model(DEM)-based geochemical model(DGM) was constructed. Finally, the sections of Ag, Cd, Pb, and Zn were obtained using pXRFA. The results show that Ag-Pb-Zn-Cd enrichment zones were mostly located around the contact belt of volcanic rocks and intrusions, or along SE-NW trending faults. Considering the variable terrain and catchment basin, the extension of long axes of Ag-Pb-Zn-Cd anomalies into higher elevation areas that are favorable for Ag-Pb-Zn mineralization should be investigated. Anomaly maps created with the aid of a DGM show promising potential for mineralization in the Dajiacuo-Xurucuo region, and abundant Ag-Pb-Zn mineralization was identified with the assistance of pXRFA in the source areas for the geochemical anomalies in the Dajiacuo. We conclude that SFA and the S-A fractal model constitute a valid tool to identify or verify geochemical anomalies in areas of low-density stream-sediment sampling. The pXRFA can accurately determine the source of geochemical anomalies and improve anomaly verification efficiency.
基金Supported by National Key Technology Research and Development Program of China(2006BAK31B04)National High Technology Research and Development Program of China(863 Program)(2007AA01Z341)
文摘For a portable structured light system,it must be easy to use and fiexible.So the inconvenient and expensive equipment for calibration such as two or three orthogonal planes or extra fixed equipment should not be considered.For the purpose of fast 3D acquisition,the projection matrices of a portable structured light system should be estimated.This paper proposes a flexible calibration method to meet the requirements of the portable structured light system through a surface plane.A calibration board is attached to the surface plane,and a reference pattern is also projected by an LCD projector onto the surface plane.The camera observes the surface plane at a few different positions.Then,the world-to-image point pairs for the camera and projector are obtained based on the cross ratio and epipolar geometry,and the system is thus calibrated.The experiments conducted for the proposed calibration method demonstrate its accuracy and robustness.
