A novel facile procedure for traceless solid-phase synthesis of 3-substituted isoxazoles in good yields and with excellent purities using polymer-supported vinyl selenide has been developed.
Polystyrene-supported selenomethyl-sulfonates have been prepared. These novel reagents were treated with LDA to produce selenium stabilized carbanions, which reacted with alkyl halide and epoxides, followed by selenox...Polystyrene-supported selenomethyl-sulfonates have been prepared. These novel reagents were treated with LDA to produce selenium stabilized carbanions, which reacted with alkyl halide and epoxides, followed by selenoxide syn-elimination, to give E-vinyl sulfones and -hydroxy-substituted-E-vinyl sulfones respectively.展开更多
Polystyrene-supported benzyl selenide has been prepared. This novel reagent was treated with LDA to produce a selenium stabilized carbanion, which reacted with alkyl halide, followed by selenoxide syn-elimination, to...Polystyrene-supported benzyl selenide has been prepared. This novel reagent was treated with LDA to produce a selenium stabilized carbanion, which reacted with alkyl halide, followed by selenoxide syn-elimination, to give substituted olefins stereospecificly.展开更多
A novel polystyrene-supported triol resin was first prepared by reaction of the Merrifield resin with trometamol. Using this resin, arylboronic acids were efficiently isolated and purified through a ＂capture-release...A novel polystyrene-supported triol resin was first prepared by reaction of the Merrifield resin with trometamol. Using this resin, arylboronic acids were efficiently isolated and purified through a ＂capture-release＂ procedure in organic solvents. However, in basic aqueous solvents arylboronic acids were immobilized on the resin only with low yield. 2012 Tao Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.展开更多
Reaction of polystyrene-supported lithium selenide with 3-acetoxy-2-methylene-alkanoates afforded the corresponding allyl selenide resins and subsequent cleavage from the polymer by treating with methyl iodide to furn...Reaction of polystyrene-supported lithium selenide with 3-acetoxy-2-methylene-alkanoates afforded the corresponding allyl selenide resins and subsequent cleavage from the polymer by treating with methyl iodide to furnish （Z）-allyl iodides in good yields and high purities. The polymeric selenium reagent can be regenerated and reused. So it is a environmentally benign reagent.展开更多
Chiral bisoxazoline(box)ligands with indene groups at C4 and C5 are highly potent in asymmetric catalysis,but face challenges in terms of cost and recyclability.To address this,we have designed polystyrene-supported b...Chiral bisoxazoline(box)ligands with indene groups at C4 and C5 are highly potent in asymmetric catalysis,but face challenges in terms of cost and recyclability.To address this,we have designed polystyrene-supported box ligands by modifying the indene moiety instead of the traditional methylene bridge.This design preserves the necessary steric environment for copper coordination,enabling high efficiency and excellent enantioselectivity as examined in photoinduced asymmetric cyanation reactions.The resulting copper complexes are robust and recyclable,maintaining performance over five cycles.This approach provides a sustainable and practical solution for asymmetric catalysis with chiral box ligands.展开更多
A novel facile solid-phase organic synthesis of aryl vinyl ethers by reaction of polystyrene-supported 2-phenylsulfonylethanol with phenols under Mitsunobu conditions and subsequent elimination reaction with DBU has b...A novel facile solid-phase organic synthesis of aryl vinyl ethers by reaction of polystyrene-supported 2-phenylsulfonylethanol with phenols under Mitsunobu conditions and subsequent elimination reaction with DBU has been developed. The advantages of this method include straightforward operation, good yield and high purity of the products. Alternatively, a typical example of Suzuki coupling reaction on-resin was further applied to prepare 4-phenylphenyl vinyl ether for extending this method.展开更多
基金We thank the National Natural Science Foundation of China(No.20562005)NSF of Jiangxi Province for financial support.
文摘A novel facile procedure for traceless solid-phase synthesis of 3-substituted isoxazoles in good yields and with excellent purities using polymer-supported vinyl selenide has been developed.
文摘Polystyrene-supported selenomethyl-sulfonates have been prepared. These novel reagents were treated with LDA to produce selenium stabilized carbanions, which reacted with alkyl halide and epoxides, followed by selenoxide syn-elimination, to give E-vinyl sulfones and -hydroxy-substituted-E-vinyl sulfones respectively.
基金Project 29932020 was supported by the National Natural Science Foundation of China.
文摘Polystyrene-supported benzyl selenide has been prepared. This novel reagent was treated with LDA to produce a selenium stabilized carbanion, which reacted with alkyl halide, followed by selenoxide syn-elimination, to give substituted olefins stereospecificly.
文摘A novel polystyrene-supported triol resin was first prepared by reaction of the Merrifield resin with trometamol. Using this resin, arylboronic acids were efficiently isolated and purified through a ＂capture-release＂ procedure in organic solvents. However, in basic aqueous solvents arylboronic acids were immobilized on the resin only with low yield. 2012 Tao Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.
基金the National Natural Science Foundation of China （No. 20562005） NSF of Jiangxi Province （No. 0620021） for financial support.
文摘Reaction of polystyrene-supported lithium selenide with 3-acetoxy-2-methylene-alkanoates afforded the corresponding allyl selenide resins and subsequent cleavage from the polymer by treating with methyl iodide to furnish （Z）-allyl iodides in good yields and high purities. The polymeric selenium reagent can be regenerated and reused. So it is a environmentally benign reagent.
基金the National Natural Science Foundation of China(Nos.92256301,22371085,22271113,22471089)the National Key R&D Program of China(Nos.2023YFA1507203,2024YFA1509700)+4 种基金the Fundamental Research Funds for the Central Universities(No.CCNU24JCPT018)the Wuhan Natural Science Foundation(No.2024040801020303)the Postdoctor Project of Hubei Province under Grant Number 2024HBBHCXB039the China Postdoctoral Science Foundation(No.2024M751614)First Batch of Postdoctoral Overseas Talent Program of China for support of this research.
文摘Chiral bisoxazoline(box)ligands with indene groups at C4 and C5 are highly potent in asymmetric catalysis,but face challenges in terms of cost and recyclability.To address this,we have designed polystyrene-supported box ligands by modifying the indene moiety instead of the traditional methylene bridge.This design preserves the necessary steric environment for copper coordination,enabling high efficiency and excellent enantioselectivity as examined in photoinduced asymmetric cyanation reactions.The resulting copper complexes are robust and recyclable,maintaining performance over five cycles.This approach provides a sustainable and practical solution for asymmetric catalysis with chiral box ligands.
基金Acknowledgement This work was supported by the National Natural Science Foundation of China （No. 21062007） and the Research Program of Jiangxi Province Department of Education （No. GJJ10385, GJJ11380）.
文摘A novel facile solid-phase organic synthesis of aryl vinyl ethers by reaction of polystyrene-supported 2-phenylsulfonylethanol with phenols under Mitsunobu conditions and subsequent elimination reaction with DBU has been developed. The advantages of this method include straightforward operation, good yield and high purity of the products. Alternatively, a typical example of Suzuki coupling reaction on-resin was further applied to prepare 4-phenylphenyl vinyl ether for extending this method.
