Polyphenols,a diverse group of naturally occurring compounds found in plants,have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases(NDs).The Wnt/β-cateni...Polyphenols,a diverse group of naturally occurring compounds found in plants,have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases(NDs).The Wnt/β-catenin(WβC)signaling pathway,a crucial player in neurogenesis,neuronal survival,and synaptic plasticity,is involved in several cellular mechanisms related to NDs.Dysregulation of this pathway is a hallmark in the development of various NDs.This study explores multiple polyphenolic compounds,such as flavonoids,stilbenes,lignans,and phenolic acids,and their potential to protect the nervous system.It provides a comprehensive analysis of their effects on the WβC pathway,elucidating their modes of action.The study highlights the dual function of polyphenols in regulating and protecting the nervous system,providing reassurance about the research benefits.This review provides a comprehensive analysis of the results obtained from both in vitro studies and in vivo research,shedding light on how these substances influence the various components of the pathway.The focus is mainly on the molecular mechanisms that allow polyphenols to reduce oxidative stress,inflammation,and apoptotic processes,ultimately improving the function and survival of neurons.This study aims to offer a thorough understanding of the potential of polyphenols in targeting the WβC signaling pathway,which could lead to the development of innovative therapeutic options for NDs.展开更多
Depression is a common psychiatric condition with a considerable influence on global health.Although current pharmacotherapeutic choices are of indisputable relevance,there is sustained interest in natural medicines f...Depression is a common psychiatric condition with a considerable influence on global health.Although current pharmacotherapeutic choices are of indisputable relevance,there is sustained interest in natural medicines for treating depressive symptoms.Polyphenols,a class of plant-derived natural compounds,have received attention due to their possible neuroprotective and anti-depressive properties.In this review,we aimed to present the intricate mechanisms through which polyphenols modulate inflammation,neurogenesis,oxidative stress,and the gut microbiota.Consumption of polyphenol-rich diets is emerging as a non-invasive,natural,and cost-effective approach to supporting brain health,with potential influence on depressive symptoms.While there have been promising results,more research is needed to draw solid conclusions regarding the medicinal potential of polyphenols.展开更多
Epilepsy is a devastating neurological condition that affects over 70 million people worldwide.Apart from idiopathic epilepsy,numerous diseases have been reported to cause secondary epilepsy.Polyphenols,ubiquitously e...Epilepsy is a devastating neurological condition that affects over 70 million people worldwide.Apart from idiopathic epilepsy,numerous diseases have been reported to cause secondary epilepsy.Polyphenols,ubiquitously existing in fruits and vegetables,has become a promising neuroprotective candidate against multiple neurological abnormalities due to its interplay with gut microbiome composed of the bacterial population in gastrointestinal system.This bioactive compound is also being tested for the management of epileptogenesis.However,there is still insufficient evidence from mechanistic studies to demonstrate the causal relationship between anti-epileptic effect of polyphenols and microbial alteration.In this review,we provide the brief overview of epilepsy,polyphenols and gut microbiota.We then analysis the association of polyphenols and gut microbiota particularly in the epilepsy and symptomatic seizures-induced by epilepsy related disorders.We also discuss the possibility for the combined application with probiotics to improve the bioavailability and bioaccessibility of polyphenols for expanding its anti-epileptic function.We finally summarize the therapeutic potential of anti-seizure polyphenols through affecting gut microbiome,and propose that the anti-epileptic effect of polyphenols may be tightly relevant to intestinal bacterial flora for overcoming epilepsy and its comorbidities simultaneously.Therefore,the dietary polyphenols targeting specific bacteria may achieve the outcome of‘one stone,two birds’.展开更多
The absence of trace amounts of natural bioactive compounds with important biological activities in traditional dietary models for global farm animals,coupled with an incomplete theoretical system for animal nutrition...The absence of trace amounts of natural bioactive compounds with important biological activities in traditional dietary models for global farm animals,coupled with an incomplete theoretical system for animal nutrition,has led to unbalanced and inadequate animal nutrition.This deficiency has adversely impacted animal health and the ecological environment,presenting formidable challenges to the advancement of the swine breeding industry in various countries around the world toward high-quality development.Recently,due to the ban of antibiotics for growth promotion in swine diets,botanical active compounds have been extensively investigated as feed additives.Polyphenols represent a broad group of plant secondary metabolites.They are natural,non-toxic,pollution-free,and highly reproducible compounds that have a wide range of physiological functions,such as antioxidant,anti-inflammatory,immunomodulatory,antiviral,antibacterial,and metabolic activities.Accordingly,polyphenols have been widely studied and used as feed additives in swine production.This review summarizes the structural characteristics,classification,current application situation,general properties of polyphenols,and the latest research advances on their use in swine production.Additionally,the research and application bottlenecks and future development of plant polyphenols in the animal feed industry are reviewed and prospected.This review aims to stimulate the in-depth study of natural plant polyphenols and the research and development of related products in order to promote the green,healthy,and high-quality development of swine production,while also providing ideas for the innovation and development in the theoretical system of animal nutrition.展开更多
Emerging evidence highlights the potential of bioactive compounds,particularly polyphenols,as adjunctive therapeutic agents in the treatment of pancreatic cancer(PC),one of the most aggressive malignancies.This review...Emerging evidence highlights the potential of bioactive compounds,particularly polyphenols,as adjunctive therapeutic agents in the treatment of pancreatic cancer(PC),one of the most aggressive malignancies.This review focuses on epigallocatechin gallate(EGCG)and resveratrol due to their extensively documented anticancer activity,favorable safety profiles,and their unique ability to modulate multiple signaling pathways relevant to pan-creatic tumorigenesis.Among polyphenols,these two have shown superior anti-cancer activity,epigenetic regulatory effects,and synergy with standard chemotherapies in preclinical pancreatic cancer models.Resveratrol exhibits anti-proliferative effects by modulating key signaling pathways,including phosphatidylinositol 3 kinase(PI3K)/protein kinase B(Akt),nuclear factor kappa-B(NF-κB),and tumor protein 53(p53).EGCG exerts anti-cancer activity by targeting multiple cellular processes,such as oxidative stress reduction,and suppression of inflammatory mediators like Interleukin-6(IL-6)and Tumor Necrosis Factor-α(TNF-α).Both EGCG and resveratrol exert anti-pancreatic cancer effects partly through direct interactions with cell surface receptors and modulation of intracellular cascades.EGCG targets the 67 kDa laminin receptor(67LR),which is overexpressed in pancreatic cancer cells,triggering apoptosis,cyclic guanosine monophosphate(cGMP)production and activation of the PKCδ/acid sphingomyelinase(ASM)cascade.Resveratrol inhibits insulin-like growth factor-1 receptor(IGF-1R)activation of the PI3K/Akt and Wnt signaling pathways,while concurrently activating tumor suppressor p53.These interactions suppress proliferation,promote apoptosis,and reduce epithelial-mesenchymal transition(EMT),thereby limiting tumor progression.Both polyphenols enhance chemosensitivity and reduce resistance to conventional therapies,including gemcitabine,by modulating drug transporters and apoptotic pathways.Furthermore,their epigenetic influence,particularly via DNA methylation and histone modification,suggests a broader role in pancreatic cancer prevention.Understanding the roles and mechanisms of resveratrol and EGCG in pancreatic cancer provides valuable insights into novel treatment strategies.The integration of polyphenols into conventional therapeutic approaches may offer new hope for improving patient outcomes.展开更多
Gut microbiota regulate the activation of adipose browning,which promote energy dissipation and combat diet-induced obesity.Pomegranate peel polyphenols(PPPs)have been shown to reduce obesity,regulate lipid metabolism...Gut microbiota regulate the activation of adipose browning,which promote energy dissipation and combat diet-induced obesity.Pomegranate peel polyphenols(PPPs)have been shown to reduce obesity,regulate lipid metabolism in adipose tissue,and modulate the composition of gut microbiota in animal fed high-fat diet(HFD).However,the role of gut microbiota in the improvement of obesity by PPPs has not been elucidated.In current study,we applied antibiotics to inhibit gut microbiota in mice fed HFD and treated with PPPs.The results showed that the inhibition of gut microbiota impair the effect of PPPs on reducing obesity and promoting adipose browning,and change the fecal metabolomic profiles in respond to PPPs.Moreover,the inhibition of gut microbiota supressed the promotive effects of PPPs on the levels of Akkermansia and microbiota-related metabolites,such as urolithin A,short-chain fatty acids(SCFAs),and bile acids(BAs),which were associated with activating adipose browning.Therefore,our results suggested that the presence of gut microbiota is essential for PPPs to ameliorate HFD-induced obesity.The related bacteria or metabolites generated by the interaction between PPPs and microbiota promote adipose browning and facilitate the beneficial effects of PPPs.展开更多
Climate change is significantly altering viticultural practices worldwide,with profound implications for the accumulation of polyphenolic compounds that determine wine’s sensory and health properties.This review summ...Climate change is significantly altering viticultural practices worldwide,with profound implications for the accumulation of polyphenolic compounds that determine wine’s sensory and health properties.This review summarizes the effects of climate change,particularly rising temperatures,shifting precipitation patterns,and altered light conditions-on polyphenol synthesis in Vitis amurensis(V.amurensis)grapes from Northeast China,the country’s highest-latitude wine region.Key findings reveal that:(1)Temperature increases accelerate phenological stages but differentially impact polyphenols,suppressing anthocyanins and flavonols while promoting tannins;(2)Precipitation variability induces water stress that can enhance anthocyanin content under moderate drought but reduce quality during extreme events;(3)Declining sunshine duration may limit polyphenol production,though certain cultivars(e.g.,Beibinghong)exhibit adaptability to low light conditions.The region’s unique climatic trends-stronger winter warming and reduced summer precipitation-paradoxically offer potential benefits by extending the growing season while minimizing heat stress during critical ripening periods.It is highlighted how V.amurensis,with its cold hardiness and naturally high polyphenol content(notably anthocyanins and resveratrol),could become increasingly valuable under climate change.However,strategic adaptation through cultivar selection,vineyard management,and stress-responsive breeding will be critical to maintain wine quality.This synthesis provides a framework for understanding climate-polyphenol dynamics in cool-climate viticulture and outlines research priorities to safeguard the future of Northeast China’s distinctive wine industry.展开更多
Apple polyphenols are widely present in apple pulp,peel,kernel,and leaves.They are natural bioactive substances with a variety of health functions.This review describes the antioxidant functions of anthocyanins,querce...Apple polyphenols are widely present in apple pulp,peel,kernel,and leaves.They are natural bioactive substances with a variety of health functions.This review describes the antioxidant functions of anthocyanins,quercetin,phlorizin,chlorogenic acid,and epicatechin in apple polyphenols through the regulation of signal pathways and transcription factors,and the inhibition or induction of enzymes.Massive food applications of apple polyphenols are summarized,including excellent color protection of fruits and vegetables,meat preservation,preparation of composite packaging fi lms as active ingredients,enhancement of nutritional value as functional ingredients,and improvement of food taste and physical stability.This review would provide a reference for the exploration of apple polyphenol resources and its development in the food field.展开更多
Whole-grain foods have attracted emerging attention due to their health benefits.Whole grains are rich in bound polyphenols(BPs)linked with dietary fibers,which is largely underestimated compared with free polyphenols...Whole-grain foods have attracted emerging attention due to their health benefits.Whole grains are rich in bound polyphenols(BPs)linked with dietary fibers,which is largely underestimated compared with free polyphenols.In this study,in vitro simulated gastrointestinal digestion and colonic fermentation models were used to study the release profile and metabolism of BPs of oat bran.Significantly higher level of BPs was released during in vitro colon fermentation(3.05 mg GAE/g)than in gastrointestinal digestion(0.54 mg GAE/g).Five polyphenols were detected via LC-MS and their possible conversion pathways were speculated.Released BPs exhibited chemical antioxidant capacity.16S rRNA sequencing further revealed that Clostridium butyricum,Enterococcus faecalis,Bacteroides acidifaciens were the key bacteria involved in the release of BPs,and this was verified by whole-cell transformation.Our results helped to explain the possible mechanism of the health benefits of BPs in whole grains.展开更多
The aim of this study was to explore the mechanism of action of sea buckthorn polyphenols in the treatment of hyperlipidemia through network pharmacology and molecular docking.The TCMSP pharmacology database was used ...The aim of this study was to explore the mechanism of action of sea buckthorn polyphenols in the treatment of hyperlipidemia through network pharmacology and molecular docking.The TCMSP pharmacology database was used to screen the polyphenols present in sea buckthorn,and then the SwissTargetPrediction and Uniprot databases were used to obtain the potential targets of sea buckthorn polyphenols,which were supplemented by the literature.In total,7 polyphenols and 154 potential targets were obtained.Through GeneCards,OMIM database,1358 hyperlipidemia-related targets were collected.We found that there were 101 targets at the intersection of components and diseases.Through GO and KEGG enrichment analysis,27 core targets were obtained,which were AKT1,TNF,TP53,IL-6,etc.in order of degree value.174 pathways were obtained from KEGG enrichment analysis,including AGE-RAGE signaling pathway in diabetic complications,fl uid shear stress and atherosclerosis,lipid and atherosclerosis,etc.The molecular docking of the main components to the targets was performed using OpenBabelGUI,AutoDockTools-1.5.6 software.Finally,the results were visualized using Cytoscape 3.9.1 software.The molecular docking results showed that sea buckthorn polyphenols have good binding ability with the key targets.Among them,such as quercetin and kaempferol,have good binding ability with TNF,TP53 and IL-6.For example,TNF binds to quercetin with a binding energy of-5.34 kcal/mol and to kaempferol with a binding energy of-6.22 kcal/mol;TP53 binds to kaempferol with a binding energy of-5.32 kcal/mol;IL-6 binds to quercetin with a binding energy of-5.62 kcal/mol,etc.Therefore,the network pharmacology study showed that the treatment of hyperlipidemia by sea buckthorn polyphenols can be realized by multi-component-multi-target-multi-pathway together,which provides some reference for the later study of sea buckthorn polyphenols in the treatment of hyperlipidemia.展开更多
This study employs combined network pharmacology and molecular docking approaches to investigate the potential mechanisms by which Erigeron breviscapus polyphenols inhibit liver fibrosis.Active compounds were identifi...This study employs combined network pharmacology and molecular docking approaches to investigate the potential mechanisms by which Erigeron breviscapus polyphenols inhibit liver fibrosis.Active compounds were identified through literature mining,with targets predicted using TCMSP,PubChem,SwissTarget,and SwissADME databases.Liver fibrosis-related targets were retrieved from GeneCards,OMIM,and TTD.Following rigorous screening,12 bioactive polyphenolic compounds and 117 corresponding targets were identified,intersecting with 8,375 liver fibrosis targets to yield 67 common targets.Protein-protein interaction analysis revealed 80 key targets(e.g.,EGFR,ESR1,PTGS2).GO and KEGG analyses indicated enrichment in 352 biological terms and 50 pathways,including chemical carcinogenesis receptor activation and steroid hormone biosynthesis.Molecular docking confirmed effective binding affinity between the top four compounds(by degree value)and their respective targets.In summary,the results of this study indicate that Erigeron breviscapus can inhibit the development of liver fibrosis and related diseases through multiple components,targets,and pathways.This study provides a solid theoretical basis for the research of Erigeron breviscapus in the field of anti liver fibrosis.展开更多
[Objective] The aim was to study the antioxidant effect of polyphenols from pomegranate peel in vivo. [Method] The Kunming rats were randomly divided into a control group, a low-dose group, a middle-dose group and a h...[Objective] The aim was to study the antioxidant effect of polyphenols from pomegranate peel in vivo. [Method] The Kunming rats were randomly divided into a control group, a low-dose group, a middle-dose group and a high-dose group,n=10; the protein content, the activities of the superoxide dismutase（SOD） and the glutathione peroxidase（GSH-PX）, the content of the maleic dialdehyde（MDA） in serum and liver tissue of the rats from different groups were determined. [Result]The polyphenols of pomegranate peel could increase protein content, activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-PX） in serum and liver tissue, and decrease the maleic dialdehyde（MDA） content simultaneously. [Conclusion] Polyphenols of pomegranate peel have strong antioxidant activity in vivo.展开更多
Aim Isolation and structural elucidation of the constituents from the aerial part of Vitis thunbergii . Methods To isolate chemical constituents, column chromatography and HPLC were used. Physico chemical ...Aim Isolation and structural elucidation of the constituents from the aerial part of Vitis thunbergii . Methods To isolate chemical constituents, column chromatography and HPLC were used. Physico chemical characterization and spectroscopic analysis were employed for structural identification. Results Eleven polyphenols were isolated and identified. Conclusion Compound 1 is a new compound and its structure was characterized to be 3,5 dimethoxyl 4 hydroxyl phenylpropanol 9 O β D glycopyranoside.展开更多
[Objective] We aimed to investigate the differences of polyphenols content in Anxi Tieguanyin tea among different seasons and relationship between polyphenols and tea quality.[Method] The content of total polyphenols ...[Objective] We aimed to investigate the differences of polyphenols content in Anxi Tieguanyin tea among different seasons and relationship between polyphenols and tea quality.[Method] The content of total polyphenols and main phenolic compounds was analyzed by spectrophotometry and HPLC and the sensory quality assessment was carried out.[Result] There were significant differences in the content of polyphenols in Anxi Tieguanyin tea among different seasons.The summer tea had a higher content of polyphenols and ester type catechins and a heavier undesirable taste with more bitterness and astringency than spring tea and autumn tea with lower quality in general.The flavonol content of spring and autumn tea was significantly higher and the color of tea soup was better.[Conclusion] This study provided a basis for the quality improvement of summer tea by regulating the content of total polyphenols and provided a basic data for chemical analysis of Oolong tea.展开更多
Aging is a complex biological process characterized by nine hallmarks,including genomic instability,mitochondrial dysfunction,and chronic inflammation,which collectively drive the progression of age-related chronic no...Aging is a complex biological process characterized by nine hallmarks,including genomic instability,mitochondrial dysfunction,and chronic inflammation,which collectively drive the progression of age-related chronic non-communicable diseases.Phytonutrients,a class of bioactive secondary metabolites abundant in plants,have emerged as a promising research focus for intervening in the aging process due to their multifaceted biological activities.This review systematically elaborates on the molecular mechanisms,key signaling pathways,specifically SIRT1,Nrf2/ARE,and AMPK/mTOR,and the synergistic anti-aging effects of four typical phytonutrient categories:polyphenols(e.g.,resveratrol,quercetin),carotenoids(e.g.,lycopene,astaxanthin),sulfur compounds(e.g.,α-lipoic acid,ergothioneine),and phytoestrogens(e.g.,soybean isoflavones).The evidence indicates that these compounds combat aging through a multidimensional network involving direct antioxidant actions,free radical scavenging,metal chelation,promotion of autophagy,and modulation of inflammatory and epigenetic pathways.Crucially,the review highlights that synergistic interactions between different phytonutrients can significantly enhance their efficacy beyond the effect of any single compound.The aim is to consolidate the anti-aging evidence of phytonutrients and address the current translational challenges,such as bioavailability and a lack of robust human trials,thereby providing a comprehensive theoretical framework for developing effective,diet-centered strategies to promote healthy aging and reduce the global burden of non-communicable diseases.展开更多
基金financially supporting this work through the Large Research Group Project under Grant no.R.G.P.2/509/45
文摘Polyphenols,a diverse group of naturally occurring compounds found in plants,have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases(NDs).The Wnt/β-catenin(WβC)signaling pathway,a crucial player in neurogenesis,neuronal survival,and synaptic plasticity,is involved in several cellular mechanisms related to NDs.Dysregulation of this pathway is a hallmark in the development of various NDs.This study explores multiple polyphenolic compounds,such as flavonoids,stilbenes,lignans,and phenolic acids,and their potential to protect the nervous system.It provides a comprehensive analysis of their effects on the WβC pathway,elucidating their modes of action.The study highlights the dual function of polyphenols in regulating and protecting the nervous system,providing reassurance about the research benefits.This review provides a comprehensive analysis of the results obtained from both in vitro studies and in vivo research,shedding light on how these substances influence the various components of the pathway.The focus is mainly on the molecular mechanisms that allow polyphenols to reduce oxidative stress,inflammation,and apoptotic processes,ultimately improving the function and survival of neurons.This study aims to offer a thorough understanding of the potential of polyphenols in targeting the WβC signaling pathway,which could lead to the development of innovative therapeutic options for NDs.
基金Supported by the Ministry of Science,Technological Development and Innovation of the Republic of Serbia,No.451-03-137/2025-03/200111 and No.451-03-137/2025-03/200146.
文摘Depression is a common psychiatric condition with a considerable influence on global health.Although current pharmacotherapeutic choices are of indisputable relevance,there is sustained interest in natural medicines for treating depressive symptoms.Polyphenols,a class of plant-derived natural compounds,have received attention due to their possible neuroprotective and anti-depressive properties.In this review,we aimed to present the intricate mechanisms through which polyphenols modulate inflammation,neurogenesis,oxidative stress,and the gut microbiota.Consumption of polyphenol-rich diets is emerging as a non-invasive,natural,and cost-effective approach to supporting brain health,with potential influence on depressive symptoms.While there have been promising results,more research is needed to draw solid conclusions regarding the medicinal potential of polyphenols.
基金supported by the National Natural Science Foundation Committee of China(81971212,81601129)Shenyang Young and Middle-aged Technological Innovation Talent Support Program(RC210268)Liaoning Province Natural Science Foundation(2023-MS-153).
文摘Epilepsy is a devastating neurological condition that affects over 70 million people worldwide.Apart from idiopathic epilepsy,numerous diseases have been reported to cause secondary epilepsy.Polyphenols,ubiquitously existing in fruits and vegetables,has become a promising neuroprotective candidate against multiple neurological abnormalities due to its interplay with gut microbiome composed of the bacterial population in gastrointestinal system.This bioactive compound is also being tested for the management of epileptogenesis.However,there is still insufficient evidence from mechanistic studies to demonstrate the causal relationship between anti-epileptic effect of polyphenols and microbial alteration.In this review,we provide the brief overview of epilepsy,polyphenols and gut microbiota.We then analysis the association of polyphenols and gut microbiota particularly in the epilepsy and symptomatic seizures-induced by epilepsy related disorders.We also discuss the possibility for the combined application with probiotics to improve the bioavailability and bioaccessibility of polyphenols for expanding its anti-epileptic function.We finally summarize the therapeutic potential of anti-seizure polyphenols through affecting gut microbiome,and propose that the anti-epileptic effect of polyphenols may be tightly relevant to intestinal bacterial flora for overcoming epilepsy and its comorbidities simultaneously.Therefore,the dietary polyphenols targeting specific bacteria may achieve the outcome of‘one stone,two birds’.
基金supported by the National Natural Science Foundation of China(U22A20515&32102578)the National Key R&D Program of China(2023YFD1302300)+1 种基金the Science and Technology Research Project of Education Department of Jiangxi Province(GJJ191140)the Doctoral Foundation of Nanchang Normal University(NSBSJJ2019002)。
文摘The absence of trace amounts of natural bioactive compounds with important biological activities in traditional dietary models for global farm animals,coupled with an incomplete theoretical system for animal nutrition,has led to unbalanced and inadequate animal nutrition.This deficiency has adversely impacted animal health and the ecological environment,presenting formidable challenges to the advancement of the swine breeding industry in various countries around the world toward high-quality development.Recently,due to the ban of antibiotics for growth promotion in swine diets,botanical active compounds have been extensively investigated as feed additives.Polyphenols represent a broad group of plant secondary metabolites.They are natural,non-toxic,pollution-free,and highly reproducible compounds that have a wide range of physiological functions,such as antioxidant,anti-inflammatory,immunomodulatory,antiviral,antibacterial,and metabolic activities.Accordingly,polyphenols have been widely studied and used as feed additives in swine production.This review summarizes the structural characteristics,classification,current application situation,general properties of polyphenols,and the latest research advances on their use in swine production.Additionally,the research and application bottlenecks and future development of plant polyphenols in the animal feed industry are reviewed and prospected.This review aims to stimulate the in-depth study of natural plant polyphenols and the research and development of related products in order to promote the green,healthy,and high-quality development of swine production,while also providing ideas for the innovation and development in the theoretical system of animal nutrition.
文摘Emerging evidence highlights the potential of bioactive compounds,particularly polyphenols,as adjunctive therapeutic agents in the treatment of pancreatic cancer(PC),one of the most aggressive malignancies.This review focuses on epigallocatechin gallate(EGCG)and resveratrol due to their extensively documented anticancer activity,favorable safety profiles,and their unique ability to modulate multiple signaling pathways relevant to pan-creatic tumorigenesis.Among polyphenols,these two have shown superior anti-cancer activity,epigenetic regulatory effects,and synergy with standard chemotherapies in preclinical pancreatic cancer models.Resveratrol exhibits anti-proliferative effects by modulating key signaling pathways,including phosphatidylinositol 3 kinase(PI3K)/protein kinase B(Akt),nuclear factor kappa-B(NF-κB),and tumor protein 53(p53).EGCG exerts anti-cancer activity by targeting multiple cellular processes,such as oxidative stress reduction,and suppression of inflammatory mediators like Interleukin-6(IL-6)and Tumor Necrosis Factor-α(TNF-α).Both EGCG and resveratrol exert anti-pancreatic cancer effects partly through direct interactions with cell surface receptors and modulation of intracellular cascades.EGCG targets the 67 kDa laminin receptor(67LR),which is overexpressed in pancreatic cancer cells,triggering apoptosis,cyclic guanosine monophosphate(cGMP)production and activation of the PKCδ/acid sphingomyelinase(ASM)cascade.Resveratrol inhibits insulin-like growth factor-1 receptor(IGF-1R)activation of the PI3K/Akt and Wnt signaling pathways,while concurrently activating tumor suppressor p53.These interactions suppress proliferation,promote apoptosis,and reduce epithelial-mesenchymal transition(EMT),thereby limiting tumor progression.Both polyphenols enhance chemosensitivity and reduce resistance to conventional therapies,including gemcitabine,by modulating drug transporters and apoptotic pathways.Furthermore,their epigenetic influence,particularly via DNA methylation and histone modification,suggests a broader role in pancreatic cancer prevention.Understanding the roles and mechanisms of resveratrol and EGCG in pancreatic cancer provides valuable insights into novel treatment strategies.The integration of polyphenols into conventional therapeutic approaches may offer new hope for improving patient outcomes.
基金supported by the National Natural Science Foundation of China(32001679 and 31871801)the Science and Technology Research of Shaanxi Province(2021QFY07-03)+1 种基金supported by the Fundamental Research Funds for the Central Universities(GK202103098)the Scientific and Technological Achievements Commercialization Program of Shaanxi(2023-YDCGZH-13)。
文摘Gut microbiota regulate the activation of adipose browning,which promote energy dissipation and combat diet-induced obesity.Pomegranate peel polyphenols(PPPs)have been shown to reduce obesity,regulate lipid metabolism in adipose tissue,and modulate the composition of gut microbiota in animal fed high-fat diet(HFD).However,the role of gut microbiota in the improvement of obesity by PPPs has not been elucidated.In current study,we applied antibiotics to inhibit gut microbiota in mice fed HFD and treated with PPPs.The results showed that the inhibition of gut microbiota impair the effect of PPPs on reducing obesity and promoting adipose browning,and change the fecal metabolomic profiles in respond to PPPs.Moreover,the inhibition of gut microbiota supressed the promotive effects of PPPs on the levels of Akkermansia and microbiota-related metabolites,such as urolithin A,short-chain fatty acids(SCFAs),and bile acids(BAs),which were associated with activating adipose browning.Therefore,our results suggested that the presence of gut microbiota is essential for PPPs to ameliorate HFD-induced obesity.The related bacteria or metabolites generated by the interaction between PPPs and microbiota promote adipose browning and facilitate the beneficial effects of PPPs.
文摘Climate change is significantly altering viticultural practices worldwide,with profound implications for the accumulation of polyphenolic compounds that determine wine’s sensory and health properties.This review summarizes the effects of climate change,particularly rising temperatures,shifting precipitation patterns,and altered light conditions-on polyphenol synthesis in Vitis amurensis(V.amurensis)grapes from Northeast China,the country’s highest-latitude wine region.Key findings reveal that:(1)Temperature increases accelerate phenological stages but differentially impact polyphenols,suppressing anthocyanins and flavonols while promoting tannins;(2)Precipitation variability induces water stress that can enhance anthocyanin content under moderate drought but reduce quality during extreme events;(3)Declining sunshine duration may limit polyphenol production,though certain cultivars(e.g.,Beibinghong)exhibit adaptability to low light conditions.The region’s unique climatic trends-stronger winter warming and reduced summer precipitation-paradoxically offer potential benefits by extending the growing season while minimizing heat stress during critical ripening periods.It is highlighted how V.amurensis,with its cold hardiness and naturally high polyphenol content(notably anthocyanins and resveratrol),could become increasingly valuable under climate change.However,strategic adaptation through cultivar selection,vineyard management,and stress-responsive breeding will be critical to maintain wine quality.This synthesis provides a framework for understanding climate-polyphenol dynamics in cool-climate viticulture and outlines research priorities to safeguard the future of Northeast China’s distinctive wine industry.
文摘Apple polyphenols are widely present in apple pulp,peel,kernel,and leaves.They are natural bioactive substances with a variety of health functions.This review describes the antioxidant functions of anthocyanins,quercetin,phlorizin,chlorogenic acid,and epicatechin in apple polyphenols through the regulation of signal pathways and transcription factors,and the inhibition or induction of enzymes.Massive food applications of apple polyphenols are summarized,including excellent color protection of fruits and vegetables,meat preservation,preparation of composite packaging fi lms as active ingredients,enhancement of nutritional value as functional ingredients,and improvement of food taste and physical stability.This review would provide a reference for the exploration of apple polyphenol resources and its development in the food field.
基金the support from the research grants by National Natural Science Foundation of China(32202051)National Key R&D Program of China(2022YFF1100104)the Major Project of Inner Mongolia Science and Technology Department,China(2021ZD0002)。
文摘Whole-grain foods have attracted emerging attention due to their health benefits.Whole grains are rich in bound polyphenols(BPs)linked with dietary fibers,which is largely underestimated compared with free polyphenols.In this study,in vitro simulated gastrointestinal digestion and colonic fermentation models were used to study the release profile and metabolism of BPs of oat bran.Significantly higher level of BPs was released during in vitro colon fermentation(3.05 mg GAE/g)than in gastrointestinal digestion(0.54 mg GAE/g).Five polyphenols were detected via LC-MS and their possible conversion pathways were speculated.Released BPs exhibited chemical antioxidant capacity.16S rRNA sequencing further revealed that Clostridium butyricum,Enterococcus faecalis,Bacteroides acidifaciens were the key bacteria involved in the release of BPs,and this was verified by whole-cell transformation.Our results helped to explain the possible mechanism of the health benefits of BPs in whole grains.
基金supported by 2024 Liaoning Province Graduate Education Teaching Reform Research Project(LNYJG2024251).
文摘The aim of this study was to explore the mechanism of action of sea buckthorn polyphenols in the treatment of hyperlipidemia through network pharmacology and molecular docking.The TCMSP pharmacology database was used to screen the polyphenols present in sea buckthorn,and then the SwissTargetPrediction and Uniprot databases were used to obtain the potential targets of sea buckthorn polyphenols,which were supplemented by the literature.In total,7 polyphenols and 154 potential targets were obtained.Through GeneCards,OMIM database,1358 hyperlipidemia-related targets were collected.We found that there were 101 targets at the intersection of components and diseases.Through GO and KEGG enrichment analysis,27 core targets were obtained,which were AKT1,TNF,TP53,IL-6,etc.in order of degree value.174 pathways were obtained from KEGG enrichment analysis,including AGE-RAGE signaling pathway in diabetic complications,fl uid shear stress and atherosclerosis,lipid and atherosclerosis,etc.The molecular docking of the main components to the targets was performed using OpenBabelGUI,AutoDockTools-1.5.6 software.Finally,the results were visualized using Cytoscape 3.9.1 software.The molecular docking results showed that sea buckthorn polyphenols have good binding ability with the key targets.Among them,such as quercetin and kaempferol,have good binding ability with TNF,TP53 and IL-6.For example,TNF binds to quercetin with a binding energy of-5.34 kcal/mol and to kaempferol with a binding energy of-6.22 kcal/mol;TP53 binds to kaempferol with a binding energy of-5.32 kcal/mol;IL-6 binds to quercetin with a binding energy of-5.62 kcal/mol,etc.Therefore,the network pharmacology study showed that the treatment of hyperlipidemia by sea buckthorn polyphenols can be realized by multi-component-multi-target-multi-pathway together,which provides some reference for the later study of sea buckthorn polyphenols in the treatment of hyperlipidemia.
基金supported by the Liaoning Provincial Department of Education(No.LJ212510163023)Liaoning Provincial Natural Science Foundation(No.2024-MSLH-443).
文摘This study employs combined network pharmacology and molecular docking approaches to investigate the potential mechanisms by which Erigeron breviscapus polyphenols inhibit liver fibrosis.Active compounds were identified through literature mining,with targets predicted using TCMSP,PubChem,SwissTarget,and SwissADME databases.Liver fibrosis-related targets were retrieved from GeneCards,OMIM,and TTD.Following rigorous screening,12 bioactive polyphenolic compounds and 117 corresponding targets were identified,intersecting with 8,375 liver fibrosis targets to yield 67 common targets.Protein-protein interaction analysis revealed 80 key targets(e.g.,EGFR,ESR1,PTGS2).GO and KEGG analyses indicated enrichment in 352 biological terms and 50 pathways,including chemical carcinogenesis receptor activation and steroid hormone biosynthesis.Molecular docking confirmed effective binding affinity between the top four compounds(by degree value)and their respective targets.In summary,the results of this study indicate that Erigeron breviscapus can inhibit the development of liver fibrosis and related diseases through multiple components,targets,and pathways.This study provides a solid theoretical basis for the research of Erigeron breviscapus in the field of anti liver fibrosis.
基金Supported by Scientific Research Projects Units of Science and Technology Department of Xinjiang Uygur Autonomous Region for Financial Support(Project No.2013911072)~~
文摘[Objective] The aim was to study the antioxidant effect of polyphenols from pomegranate peel in vivo. [Method] The Kunming rats were randomly divided into a control group, a low-dose group, a middle-dose group and a high-dose group,n=10; the protein content, the activities of the superoxide dismutase（SOD） and the glutathione peroxidase（GSH-PX）, the content of the maleic dialdehyde（MDA） in serum and liver tissue of the rats from different groups were determined. [Result]The polyphenols of pomegranate peel could increase protein content, activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-PX） in serum and liver tissue, and decrease the maleic dialdehyde（MDA） content simultaneously. [Conclusion] Polyphenols of pomegranate peel have strong antioxidant activity in vivo.
文摘Aim Isolation and structural elucidation of the constituents from the aerial part of Vitis thunbergii . Methods To isolate chemical constituents, column chromatography and HPLC were used. Physico chemical characterization and spectroscopic analysis were employed for structural identification. Results Eleven polyphenols were isolated and identified. Conclusion Compound 1 is a new compound and its structure was characterized to be 3,5 dimethoxyl 4 hydroxyl phenylpropanol 9 O β D glycopyranoside.
基金Supported by Program of Fujian Provincial Bureau of Quality and Technical Supervision--Applied Research about Exogenous Enzymes for Quality Improvement of Anxi Tieguanyin Tea(FJQI2009006)Program of Administration of Quality Supervision,Inspection and Quarantine--Application of Chemical Analysis and Quality Control in Traceable Identification of Anxi Tieguanyin Tea(201210075-3)~~
文摘[Objective] We aimed to investigate the differences of polyphenols content in Anxi Tieguanyin tea among different seasons and relationship between polyphenols and tea quality.[Method] The content of total polyphenols and main phenolic compounds was analyzed by spectrophotometry and HPLC and the sensory quality assessment was carried out.[Result] There were significant differences in the content of polyphenols in Anxi Tieguanyin tea among different seasons.The summer tea had a higher content of polyphenols and ester type catechins and a heavier undesirable taste with more bitterness and astringency than spring tea and autumn tea with lower quality in general.The flavonol content of spring and autumn tea was significantly higher and the color of tea soup was better.[Conclusion] This study provided a basis for the quality improvement of summer tea by regulating the content of total polyphenols and provided a basic data for chemical analysis of Oolong tea.
基金supported by the Shanghai Sailing Program(No.21YF1418500)the Shanghai Chenguang Program(No.21CGA70)+1 种基金the three-year action plan for strengthening the construction of the public health system in Shanghai(No.GWVI-11.2-YQ12)Additionally,we would like to thank the Shanghai Oriental Talents Program-Youth Project(Education Platform)for its support of this study.
文摘Aging is a complex biological process characterized by nine hallmarks,including genomic instability,mitochondrial dysfunction,and chronic inflammation,which collectively drive the progression of age-related chronic non-communicable diseases.Phytonutrients,a class of bioactive secondary metabolites abundant in plants,have emerged as a promising research focus for intervening in the aging process due to their multifaceted biological activities.This review systematically elaborates on the molecular mechanisms,key signaling pathways,specifically SIRT1,Nrf2/ARE,and AMPK/mTOR,and the synergistic anti-aging effects of four typical phytonutrient categories:polyphenols(e.g.,resveratrol,quercetin),carotenoids(e.g.,lycopene,astaxanthin),sulfur compounds(e.g.,α-lipoic acid,ergothioneine),and phytoestrogens(e.g.,soybean isoflavones).The evidence indicates that these compounds combat aging through a multidimensional network involving direct antioxidant actions,free radical scavenging,metal chelation,promotion of autophagy,and modulation of inflammatory and epigenetic pathways.Crucially,the review highlights that synergistic interactions between different phytonutrients can significantly enhance their efficacy beyond the effect of any single compound.The aim is to consolidate the anti-aging evidence of phytonutrients and address the current translational challenges,such as bioavailability and a lack of robust human trials,thereby providing a comprehensive theoretical framework for developing effective,diet-centered strategies to promote healthy aging and reduce the global burden of non-communicable diseases.
