Problem of search of universal system of formalization the knowledge is discussed.Philisophical,mathematical,cybernetic and computing aspects of its problem are analyzed.Foundation of polymetrical analysis as variant ...Problem of search of universal system of formalization the knowledge is discussed.Philisophical,mathematical,cybernetic and computing aspects of its problem are analyzed.Foundation of polymetrical analysis as variant of resolution of this problem is represented.We show that this system allowed resolving S.Beer centurial problem in cybernetics.Also it allowed creating the natural(operational)approach in the foundation of mathematics and system concept of computing science.展开更多
It is of great significance to find safe and effective radiosensitizers.A primary investigation has been made on fisetin's modification of radiation effect,but its radiosensitization and related mechanisms still n...It is of great significance to find safe and effective radiosensitizers.A primary investigation has been made on fisetin's modification of radiation effect,but its radiosensitization and related mechanisms still need to be deeply clarified.Furthermore,fisetin with high hydrophobicity is difficult to dissolve in water,severely limiting its research and application.In this study,we fabricated a safe and soluble radiosensitizer fisetin micelle for precisely enhancing radiotherapy by inhibiting platelet-derived growth factor receptor-β(PDGFRβ)/signal transducer and activator of transcription 1(STAT1)/signal transducer and activator of transcription 3(STAT3)/B cell lymphoma 2(Bcl-2)signaling pathway in the tumor.Systematic and detailed studies were performed to verify its radiosensitization effect in vitro and in vivo.On the cellular level,fisetin micelles selectively increased the radiosensitivity of tumor cells(CT26 and 4T1 cells)and had little effect on the sensitivity of normal mouse cells(L929 cells)to radiation.In the mouse models of colon and breast cancers,fisetin micelles showed an efficient radiosensitization capacity without apparent toxicity.Additionally,we first found that fisetin micelles played a radiotherapy sensitization role by inhibiting the PDGFRβ/STAT1/STAT3/Bcl-2 pathway activity.In general,this work not only confirmed that fisetin micelles precisely exhibit a radiosensitization effect in vitro and in vivo,but also profoundly explored its mechanisms underlying,to provide a theoretical and experimental basis for the clinical application of fisetin micelles.展开更多
The persistent need for sorbents capable of efficiently extracting selenium from radioactive wastewater has been a significant challenge.Herein,we introduce SCU-CPN-5,a robust and saleable adsorbent designed through p...The persistent need for sorbents capable of efficiently extracting selenium from radioactive wastewater has been a significant challenge.Herein,we introduce SCU-CPN-5,a robust and saleable adsorbent designed through principles of valence and configuration matching,which achieves remarkable removal of selenium oxo-anions from nuclear waste liquids.SCU-CPN-5 demonstrates unprecedented adsorption capacities,with 617 mg/g for SeO_(4)^(2-)and 333 mg/g for SeO_(3)^(2-).Additionally,it exhibits a removal efficiency of up to 99.7%for environmentally relevant concentrations of SeO_(4)^(2-).Notably,we employed in-situ Fouriertransform infrared spectroscopy to monitor the sorption process of selenium oxo-anions into the pores of the sorbent in real time,marking a significant advancement.This research not only introduces a novel approach to the design of functional materials for nuclear wastewater management but also provides a molecular-level understanding of the adsorption mechanism.展开更多
文摘Problem of search of universal system of formalization the knowledge is discussed.Philisophical,mathematical,cybernetic and computing aspects of its problem are analyzed.Foundation of polymetrical analysis as variant of resolution of this problem is represented.We show that this system allowed resolving S.Beer centurial problem in cybernetics.Also it allowed creating the natural(operational)approach in the foundation of mathematics and system concept of computing science.
基金funded by a grant from Technology Project of Science and technology department of Sichuan province(No.2018SZ0021)。
文摘It is of great significance to find safe and effective radiosensitizers.A primary investigation has been made on fisetin's modification of radiation effect,but its radiosensitization and related mechanisms still need to be deeply clarified.Furthermore,fisetin with high hydrophobicity is difficult to dissolve in water,severely limiting its research and application.In this study,we fabricated a safe and soluble radiosensitizer fisetin micelle for precisely enhancing radiotherapy by inhibiting platelet-derived growth factor receptor-β(PDGFRβ)/signal transducer and activator of transcription 1(STAT1)/signal transducer and activator of transcription 3(STAT3)/B cell lymphoma 2(Bcl-2)signaling pathway in the tumor.Systematic and detailed studies were performed to verify its radiosensitization effect in vitro and in vivo.On the cellular level,fisetin micelles selectively increased the radiosensitivity of tumor cells(CT26 and 4T1 cells)and had little effect on the sensitivity of normal mouse cells(L929 cells)to radiation.In the mouse models of colon and breast cancers,fisetin micelles showed an efficient radiosensitization capacity without apparent toxicity.Additionally,we first found that fisetin micelles played a radiotherapy sensitization role by inhibiting the PDGFRβ/STAT1/STAT3/Bcl-2 pathway activity.In general,this work not only confirmed that fisetin micelles precisely exhibit a radiosensitization effect in vitro and in vivo,but also profoundly explored its mechanisms underlying,to provide a theoretical and experimental basis for the clinical application of fisetin micelles.
基金partially supported by the Intergovernmental International Cooperation of the National Key R&D Program of China(2022YFE0105300)the National Natural Science Foundation of China(22306136,22176139,U2267222,and U1967217)+1 种基金the New Cornerstone Science Foundation through the XPLORER PRIZEthe Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘The persistent need for sorbents capable of efficiently extracting selenium from radioactive wastewater has been a significant challenge.Herein,we introduce SCU-CPN-5,a robust and saleable adsorbent designed through principles of valence and configuration matching,which achieves remarkable removal of selenium oxo-anions from nuclear waste liquids.SCU-CPN-5 demonstrates unprecedented adsorption capacities,with 617 mg/g for SeO_(4)^(2-)and 333 mg/g for SeO_(3)^(2-).Additionally,it exhibits a removal efficiency of up to 99.7%for environmentally relevant concentrations of SeO_(4)^(2-).Notably,we employed in-situ Fouriertransform infrared spectroscopy to monitor the sorption process of selenium oxo-anions into the pores of the sorbent in real time,marking a significant advancement.This research not only introduces a novel approach to the design of functional materials for nuclear wastewater management but also provides a molecular-level understanding of the adsorption mechanism.
