A copper（Ⅱ） complex [LCu2Cl4]n was synthesized by a new bis-Schiff base ligand containing quinoline unit, 1,4-bis[2-（4-fluorophenyl）iminomethyl-8-quinolinoxy]butane（L）. X-ray crystal structure shows that it is ...A copper（Ⅱ） complex [LCu2Cl4]n was synthesized by a new bis-Schiff base ligand containing quinoline unit, 1,4-bis[2-（4-fluorophenyl）iminomethyl-8-quinolinoxy]butane（L）. X-ray crystal structure shows that it is a binuclear complex, and the crystal belongs to the triclinic system, space group P1, with a = 9.387（2）, b = 9.968（2）, c = 10.291（2） ？, α = 87.532（3）, β = 63.762（2）, γ = 86.628（3）o, V = 862.1（3） ？^3, Z = 1, Dc = 1.640 Mg/m^3, F（000） = 428, R = 0.0416 and wR = 0.1141. Each Cu（Ⅱ） metal ion coordinates with a quinoline N atom, an imine N atom, an ether oxygen atom and three chlorides, forming a distorted six-coordinated octahedronal structure. Each copper（Ⅱ） complexation unit links with one of the adjacent ligand copper complexation units through the chlorido bridging groups, thus generating an infinite one-dimensional chain structure. Such 1D chains further construct a 2D network structure by π-π stacking interactions.展开更多
A new polymeric demethylcantharidato （DCA） bridged copper（II） phenanthroline （phen） complex （[Cu（DCA）（phen）]n-nH20） has been synthesized and characterized by elemental analysis, IR and electronic spectra s...A new polymeric demethylcantharidato （DCA） bridged copper（II） phenanthroline （phen） complex （[Cu（DCA）（phen）]n-nH20） has been synthesized and characterized by elemental analysis, IR and electronic spectra studies, molar conductivity measure- ment, and single crystal X-ray diffraction. The complex crystallizes in the orthorhombic space group Pbca with crystallo- graphic data： a -- 12.4537（4）/~, b = 9.3897（5） A, c = 30.1264（10） A, and Z = 8. In the crystal structure, the octahedral coordi- nated copper（II） ions are bridged by demethylcantharidate ligands into a one-dimensional zigzag-like structure with the Cu＇＂Cu separation of 6.1719/~, along with phen ligands attached to both sides of the chain altematively. Interdigitation of the chelating phen ligands of two neighboring chains via hydrophobic interaction and van der Waals forces along ac plane forms two-dimensional polymeric bilayers with discrete water sandwich layer between the adjacent polymeric bilayers. The evalua- tion of the cytotoxic activity of the copper（II） complex against HCT-8 （colorectal carcinoma）, A549 （pulmonary carcinoma）, HeLa （cervical cancer）, HepG2 （hepatocarcinoma）, BGC-823 （gastric carcinoma）, and MCF-7 （breast adenocarcinoma） cell lines revealed that it is a potent cytotoxic agent, superior to Na2DCA and phen against HeLa, HepG2 and BGC-823 cells.展开更多
文摘A copper（Ⅱ） complex [LCu2Cl4]n was synthesized by a new bis-Schiff base ligand containing quinoline unit, 1,4-bis[2-（4-fluorophenyl）iminomethyl-8-quinolinoxy]butane（L）. X-ray crystal structure shows that it is a binuclear complex, and the crystal belongs to the triclinic system, space group P1, with a = 9.387（2）, b = 9.968（2）, c = 10.291（2） ？, α = 87.532（3）, β = 63.762（2）, γ = 86.628（3）o, V = 862.1（3） ？^3, Z = 1, Dc = 1.640 Mg/m^3, F（000） = 428, R = 0.0416 and wR = 0.1141. Each Cu（Ⅱ） metal ion coordinates with a quinoline N atom, an imine N atom, an ether oxygen atom and three chlorides, forming a distorted six-coordinated octahedronal structure. Each copper（Ⅱ） complexation unit links with one of the adjacent ligand copper complexation units through the chlorido bridging groups, thus generating an infinite one-dimensional chain structure. Such 1D chains further construct a 2D network structure by π-π stacking interactions.
基金supported by the Doctoral Fund of Ministry of Education of China (20110001110054)
文摘A new polymeric demethylcantharidato （DCA） bridged copper（II） phenanthroline （phen） complex （[Cu（DCA）（phen）]n-nH20） has been synthesized and characterized by elemental analysis, IR and electronic spectra studies, molar conductivity measure- ment, and single crystal X-ray diffraction. The complex crystallizes in the orthorhombic space group Pbca with crystallo- graphic data： a -- 12.4537（4）/~, b = 9.3897（5） A, c = 30.1264（10） A, and Z = 8. In the crystal structure, the octahedral coordi- nated copper（II） ions are bridged by demethylcantharidate ligands into a one-dimensional zigzag-like structure with the Cu＇＂Cu separation of 6.1719/~, along with phen ligands attached to both sides of the chain altematively. Interdigitation of the chelating phen ligands of two neighboring chains via hydrophobic interaction and van der Waals forces along ac plane forms two-dimensional polymeric bilayers with discrete water sandwich layer between the adjacent polymeric bilayers. The evalua- tion of the cytotoxic activity of the copper（II） complex against HCT-8 （colorectal carcinoma）, A549 （pulmonary carcinoma）, HeLa （cervical cancer）, HepG2 （hepatocarcinoma）, BGC-823 （gastric carcinoma）, and MCF-7 （breast adenocarcinoma） cell lines revealed that it is a potent cytotoxic agent, superior to Na2DCA and phen against HeLa, HepG2 and BGC-823 cells.
