Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,n...Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.展开更多
Long-term exposure to fine particulate matters(PM_(2.5))has been associated with respiratory and cardiovascular diseases and the burden are potentially higher in China experiencing heavy air pollution.In this study,we...Long-term exposure to fine particulate matters(PM_(2.5))has been associated with respiratory and cardiovascular diseases and the burden are potentially higher in China experiencing heavy air pollution.In this study,we established the exposure-response association between long-term exposures to PM_(2.5)and lung function and blood pressure in Chinesemiddle-aged and older adults using linearmixed-effects and generalized additive mixedmodels based on 3 waves longitudinal health outcomes data by enrolling 19,988 participants from 121 cities across themainland of China.We also assessed the effect of Clean Air Policy(CAP)based on a quasi-experimental difference-in-differences(DID)design.A 10μg/m^(3)increase in PM_(2.5)concentration was associated with a 7.18(95%confidence interval[CI]:-8.35,-6.02)L/min decrease in PEF(peak expiratory flow)and a 0.72(95%[CI]:0.53,0.90)and a 0.30(95%[CI]:0.18,0.42)mmHg increase in systolic and diastolic blood pressure,respectively.The associations were more pronounced in males and rural areas for PEF,but similar across subgroups for blood pressure.DID results suggested that the effect of CAP on health outcomes were sensitive tomagnitudes of reduction in PM_(2.5).A 5μg/m^(3)reduction in PM_(2.5)or more generally led to 18.70(95%[CI]:0.79,36.61)higher PEF and-2.05(95%[CI]:-3.87,-0.23)lower diastolic blood pressure,respectively,compared to no reduction or increase in exposure.However,the effects were significant only in rural areas.Our analysis support CAP aiming to benefit public health and provides insights to inform future control policy for efficiently decreasing air pollution exposure burden.展开更多
In this paper,we obtain a normality criterion for families of meromorphic functions concerning‘wandering’shared functions,which generalizes and improves Montel’s criterion and the related results due to Schwick,Xu-...In this paper,we obtain a normality criterion for families of meromorphic functions concerning‘wandering’shared functions,which generalizes and improves Montel’s criterion and the related results due to Schwick,Xu-Fang,Xu-Qiu,and Grahl-Nevo.Also,a normality relationship between two families is given.展开更多
Objective To find the shortcomings of children’s drug research and development policy in China,and to put forward feasible suggestions for encouraging China’s children’s drug research and development by drawing the...Objective To find the shortcomings of children’s drug research and development policy in China,and to put forward feasible suggestions for encouraging China’s children’s drug research and development by drawing the experience from the United States.Methods To compare the similarities and differences between the policies guiding the use of children’s medicines issued by China and the United States.Results and Conclusion In recent years,the Chinese government has introduced a number of policies,but there is still a big gap in clinical trial design and drug review system compared with the policies of the United States.China should further improve the laws and regulations related to children’s medication,promote the development of clinical trials,develop pricing programs,and expand international cooperation,so as to formulate more scientific and comprehensive guiding principles for the research and development of children’s medication.展开更多
Defect engineering is a commonly methodology used to enhance the thermoelectric performance of thermoelectric PbTe by improving its electronic transport properties.At the nanoscale,defects can induce quantum tunneling...Defect engineering is a commonly methodology used to enhance the thermoelectric performance of thermoelectric PbTe by improving its electronic transport properties.At the nanoscale,defects can induce quantum tunneling effects that significantly impact the electrical properties of materials.To understand the specific mechanisms underlying the quantum transport properties of PbTe,we employ the non-equilibrium Green's function(NEGF)method to investigate the effects of intrinsic defects(point defects and grain boundaries)on the electronic transport properties of PbTe-based nanodevices from a quantum mechanical perspective.Our results show that the Pb vacancy(VPb)has the highest conduction.The conduction depends on the defect type,chemical potential and bias voltage.The presence of intrinsic point defects introduces impurity levels,facilitating the electron tunneling and leading to an increase in the transmission coefficient,thereby enhancing the electronic transport properties.For PbTe containing grain boundaries,these boundaries suppress the electronic transport properties.The Te occupied twin boundary(Te-TB)exerts a stronger inhibitory effect than the Pb occupied twin boundary(Pb-TB).Nevertheless,the combined effect between twin boundaries and point defects can enhance the electrical properties.Therefore,in order to obtain highly conductive of PbTe materials,a Te-rich synthesis environment should be used to promote the effective formation of Pb vacancy.Our work offers a comprehensive understanding of the impact of defects on electron scattering in thermoelectric materials.展开更多
Background:Against the backdrop of the complex interplay between global migration flows and the European Union’s governance system,immigrants’subjective well-being(SWB)has become a crucial indicator for assessing bo...Background:Against the backdrop of the complex interplay between global migration flows and the European Union’s governance system,immigrants’subjective well-being(SWB)has become a crucial indicator for assessing both their social integration and the effectiveness of integration policies.However,few studies have systematically linked immigration law and policy to SWB through a structured framework of human needs.This study aims to assess how European Union(EU)immigration policies influence immigrants’SWB by facilitating the fulfillment of hierarchical needs based on Maslow’s theory.Methods:Using data from the European Social Survey(ESS,2010–2023),this study analyzed 28,854 first-generation and second-generation immigrants across 24 EU member states.This study employed hierarchical regression models to assess the relative contribution of five levels of needs-physiological,safety,social,esteem,and self-actualization-in predicting life satisfaction and happiness,controlling for sociodemographic factors.Results:Safety needs-comprising perceived safety and institutional trust-produced the largest model improvement(ΔR^(2)≈0.06–0.07).Physiological needs(stable income and self-rated health)also had significant positive effect(β=0.06–0.25,p<0.001).Social and esteem needs showed moderate associations(β≈0.09–0.17,p<0.001),while self-actualization needs(education and union membership)displayed generational variation(β=0.02–0.10,p<0.01).Conclusion:This study not only validates the applicability of Maslow’s theory in migration research but also empirically establishes a policy hierarchy:ensuring physiological and safety needs as a foundation,supporting social and esteem needs,and enabling self-actualization pathways are essential for enhancing immigrant well-being.The findings offer valuable theoretical insights and practical guidance for refining immigrant integration policies within the EU’s multi-level governance structure.展开更多
In this paper,we study a class of Sturm-Liouville problems,where the boundary conditions involve eigenparameters.Firstly,by defining a new inner product which depends on the transmission conditions,we obtain a new Hil...In this paper,we study a class of Sturm-Liouville problems,where the boundary conditions involve eigenparameters.Firstly,by defining a new inner product which depends on the transmission conditions,we obtain a new Hilbert space,on which the concerned operator A is self-adjoint.Then we construct the fundamental solutions to the problem,obtain the necessary and sufficient conditions for eigenvalues,and prove that the eigenvalues are simple.Finally,we investigate Green’s functions of such problem.展开更多
Understanding the effects of point liquid loading on transversely isotropic poroelastic media is crucial for advancing geomechanics and biomechanics, where precise modeling of fluid-structure interactions is essential...Understanding the effects of point liquid loading on transversely isotropic poroelastic media is crucial for advancing geomechanics and biomechanics, where precise modeling of fluid-structure interactions is essential. This paper presents a comprehensive analysis of infinite transversely isotropic poroelasticity under a fluid source, based on Biot's theory, aiming to uncover new and previously unexplored insights in the literature. We begin our study by deriving a general solution for fluid-saturated, transversely isotropic poroelastic materials in terms of harmonic functions that satisfy sixth-order homogeneous partial differential equations, using potential theory and Almansi's theorem. Based on these general solutions and potential functions, we construct a Green's function for a point fluid source, introducing three new harmonic functions with undetermined constants. These constants are determined by enforcing continuity and equilibrium conditions. Substituting these into the general solution yields fundamental solutions for poroelasticity that provide crucial support for a wide range of project problems. Numerical results and comparisons with existing literature are provided to illustrate physical mechanisms through contour plots. Our observations reveal that all components tend to zero in the far field and become singular at the concentrated source. Additionally, the contours exhibit rapid changes near the point fluid source but display gradual variations at a distance from it. These findings highlight the intricate behavior of the system under point liquid loading, offering valuable insights for further research and practical applications.展开更多
Functionally graded materials (FGMs) are innovative materials distinguished by gradual variations in composition and structure, offering exceptional properties for diverse applications. Poly(ionic liquid)s (PILs), mer...Functionally graded materials (FGMs) are innovative materials distinguished by gradual variations in composition and structure, offering exceptional properties for diverse applications. Poly(ionic liquid)s (PILs), merging the characteristics of polymers and ionic liquids, have emerged as viable options for the development of FGMs given their tunable skeleton, ionic conductivity, and compatibility with various functional materials. This review highlights the latest advancements in the design strategies of FGMs based on porous PILs, focusing on single and multi-gradient structures. Furthermore, we also highlight their emerging applications in molecular recognition, sensing, adsorption, separation, and catalysis. By exploring the interplay between porosity, ionic functionality, and gradient architecture, this review offers perspectives on the prospects of PIL-based FGMs for tackling global challenges in energy, environment, and healthcare.展开更多
Since the end of the Cold War,the core goal of U.S.policy toward Africa has been to build its influence on the continent through development assistance and trade preferences attached with political conditionalities,de...Since the end of the Cold War,the core goal of U.S.policy toward Africa has been to build its influence on the continent through development assistance and trade preferences attached with political conditionalities,defined as“assistance for concessions”.After the September 11 attacks,counterterrorism became a priority in U.S.national security strategy,being one of the three pillars of U.S.policy toward Africa alongside assistance and trade.展开更多
Functionalization has emerged as a pivotal endeavor to tailor the surface properties of photocatalysts.We propose a facile amine functionalization strategy to establish a Cu−In−Zn−S(CIZS)/NiSx hybrid with covalent bon...Functionalization has emerged as a pivotal endeavor to tailor the surface properties of photocatalysts.We propose a facile amine functionalization strategy to establish a Cu−In−Zn−S(CIZS)/NiSx hybrid with covalent bonds using individual ethylenediamine(EDA)molecules.Our approach witnesses a remarkable photocatalytic hydrogen evolution(PHE)competence of 65.93 mmol g^(−1)h^(−1)driven by visible light,the highest value yielded by CIZS to date.X-ray absorption spectra of CIZS and density functional theory(DFT)calculations confirm the crucial amine N→Cu coordination after amine functionalization.The new emerging coordination via lone-pair electron donation profitably accesses the regulation of the coordination environment,electronic structures,and carrier behavior.Moreover,individual EDA molecule with two-terminal−NH2 group serves as a molecular bridge to hybrid CIZS and NiS_(x)cocatalyst via N→Cu and N→Ni coordination,favorably promoting efficient charge transport.This study provides advances in practical functionalizing photocatalysts.展开更多
The numerical simulation of the fluid flow and the flexible rod(s)interaction is more complicated and has lower efficiency due to the high computational cost.In this paper,a semi-resolved model coupling the computatio...The numerical simulation of the fluid flow and the flexible rod(s)interaction is more complicated and has lower efficiency due to the high computational cost.In this paper,a semi-resolved model coupling the computational fluid dynamics and the flexible rod dynamics is proposed using a two-way domain expansion method.The gov-erning equations of the flexible rod dynamics are discretized and solved by the finite element method,and the fluid flow is simulated by the finite volume method.The interaction between fluids and solid rods is modeled by introducing body force terms into the momentum equations.Referred to the traditional semi-resolved numerical model,an anisotropic Gaussian kernel function method is proposed to specify the interactive forces between flu-ids and solid bodies for non-circle rod cross-sections.A benchmark of the flow passing around a single flexible plate with a rectangular cross-section is used to validate the algorithm.Focused on the engineering applications,a test case of a finite patch of cylinders is implemented to validate the accuracy and efficiency of the coupled model.展开更多
We often hear statements like“the market raises expectations for central bank interest rate cuts,resulting in higher commodity prices”.Given the current situation,the People’s Bank of China might adopt a more accom...We often hear statements like“the market raises expectations for central bank interest rate cuts,resulting in higher commodity prices”.Given the current situation,the People’s Bank of China might adopt a more accommodative monetary policy to mitigate the impact of the China-U.S.trade friction.Will this further easing of the monetary environment lead to an increase in natural gas prices?展开更多
As one of the important policies of promoting the formation of main functional areas, the industrial policy directly determines the sustainable growth of space control ability of main functional areas. A restricted de...As one of the important policies of promoting the formation of main functional areas, the industrial policy directly determines the sustainable growth of space control ability of main functional areas. A restricted development zone is a type of main functional area which provides agricultural products and ecological products, assures the supply of national agricultural products and the stability of ecosystems, as well as safeguards the ecological functions and agricultural functions of wider regions by restricting its own development. Therefore scientific, complete and operable industrial policy support is needed. Restricted development zones are distributed widely in western China. With the restriction of their main functions, differential industrial policies should be implemented in the development of the restricted development zones: Dealing well with the relationship between industrial development and ecological protection, developing special industries which are friendly to resources and environment and appropriate for local conditions, guiding and encouraging industries to learn from regions with favorable development conditions, orderly withdrawing industries and enterprises adverse to main functions, facilitating industrial structure upgrading, optimizing industrial organization, improving industrial technological level and rationalizing industrial layout.展开更多
针对柔性直流输电系统(voltage source converter based high voltage direct current transmission,VSC-HVDC)控制参数设计过程中存在的鲁棒性差、依赖已知电路参数、工程设计经验化等问题,提出一种基于马尔科夫转换场(Markov transiti...针对柔性直流输电系统(voltage source converter based high voltage direct current transmission,VSC-HVDC)控制参数设计过程中存在的鲁棒性差、依赖已知电路参数、工程设计经验化等问题,提出一种基于马尔科夫转换场(Markov transition field,MTF)与深度确定性策略梯度算法(deep deterministic policy gradient,DDPG)结合的鲁棒性强、不依赖电路参数特性以及可视化的VSC-HVDC控制参数优化设计方法。首先,采用马尔科夫转换场将电路功率、电压等一维时序波形数据转换为二维马尔科夫转换场域图像并使用马尔科夫转换场损失函数(Markov transition field loss,MTFL)判断二维转换域图的数据波动性;其次,将MTFL损失函数与DDPG算法相结合,综合利用MTFL损失函数对系统输出时序数据动态特性评价能力更强的优点和DDPG算法泛化性能优秀的特点,实现VSC-HVDC系统控制参数优化;最后,通过MATLAB模拟和实验结果验证该方法的有效性。展开更多
We present a method to unify the calculation of Green＇s functions for an electromagnetic（EM） transmitting source embedded in a homogeneous stratified medium.A virtual interface parallel to layer interfaces is intro...We present a method to unify the calculation of Green＇s functions for an electromagnetic（EM） transmitting source embedded in a homogeneous stratified medium.A virtual interface parallel to layer interfaces is introduced through the source location.The potentials for Green＇s function are derived by decomposing the partial wave solutions to Helmholtz＇s equations into upward and downward within boundaries.The amplitudes of the potentials in each stratum are obtained recursively from the initial amplitudes at the source level.The initial amplitudes are derived by coupling with the transmitting sources and following the discontinuity of the tangential electric and magnetic fields at the source interface.Only the initial terms are related to the transmitting sources and thus need to be modified for different transmitters,whereas the kernel connected with the stratified media stays unchanged.Hence,the present method can be easily applied to EM transmitting sources with little modification.The application of the proposed method to the marine controlled-source electromagnetic method（MCSEM） demonstrates its simplicity and flexibility.展开更多
RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulat...RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulated at three levels： transcription level, translation level and post-translational level. Environmental stress enters bacterial cells through signal transduction and leads to a series of variations in microenvironment, thereby causing changes of regulator and controlling its levels based on the direct and indirect interaction between regulator and RpoS protein. In addition, RpoS protein has played special roles in bacteria, therefore the changes of RpoS protein levels will lead to variations in expression levels of a large number of genes, thereby causing variations of bacterial response to different environmental stress and changes of certain characteristics of bacteria, which provides a new strategy for the control of bacterial diseases in the future. This paper reviewed the recent progress on the regulation of RpoS protein expression and its function in several common bacteria. Due to the functional complexity of RpoS protein, there are still a lot of unknown functions to be further identified.展开更多
文摘Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.
基金supported by the National Institute of Environmental Health Sciences(NIEHS)of United States(No.R00ES027511)the National Natural Science Foundation of China(No.42201303).
文摘Long-term exposure to fine particulate matters(PM_(2.5))has been associated with respiratory and cardiovascular diseases and the burden are potentially higher in China experiencing heavy air pollution.In this study,we established the exposure-response association between long-term exposures to PM_(2.5)and lung function and blood pressure in Chinesemiddle-aged and older adults using linearmixed-effects and generalized additive mixedmodels based on 3 waves longitudinal health outcomes data by enrolling 19,988 participants from 121 cities across themainland of China.We also assessed the effect of Clean Air Policy(CAP)based on a quasi-experimental difference-in-differences(DID)design.A 10μg/m^(3)increase in PM_(2.5)concentration was associated with a 7.18(95%confidence interval[CI]:-8.35,-6.02)L/min decrease in PEF(peak expiratory flow)and a 0.72(95%[CI]:0.53,0.90)and a 0.30(95%[CI]:0.18,0.42)mmHg increase in systolic and diastolic blood pressure,respectively.The associations were more pronounced in males and rural areas for PEF,but similar across subgroups for blood pressure.DID results suggested that the effect of CAP on health outcomes were sensitive tomagnitudes of reduction in PM_(2.5).A 5μg/m^(3)reduction in PM_(2.5)or more generally led to 18.70(95%[CI]:0.79,36.61)higher PEF and-2.05(95%[CI]:-3.87,-0.23)lower diastolic blood pressure,respectively,compared to no reduction or increase in exposure.However,the effects were significant only in rural areas.Our analysis support CAP aiming to benefit public health and provides insights to inform future control policy for efficiently decreasing air pollution exposure burden.
基金Supported by the National Natural Science Foundation of China(Grant No.11471163)。
文摘In this paper,we obtain a normality criterion for families of meromorphic functions concerning‘wandering’shared functions,which generalizes and improves Montel’s criterion and the related results due to Schwick,Xu-Fang,Xu-Qiu,and Grahl-Nevo.Also,a normality relationship between two families is given.
基金This research was funded by the Social Science Project of Shenyang in 2023(SYSK2023-JD-55).
文摘Objective To find the shortcomings of children’s drug research and development policy in China,and to put forward feasible suggestions for encouraging China’s children’s drug research and development by drawing the experience from the United States.Methods To compare the similarities and differences between the policies guiding the use of children’s medicines issued by China and the United States.Results and Conclusion In recent years,the Chinese government has introduced a number of policies,but there is still a big gap in clinical trial design and drug review system compared with the policies of the United States.China should further improve the laws and regulations related to children’s medication,promote the development of clinical trials,develop pricing programs,and expand international cooperation,so as to formulate more scientific and comprehensive guiding principles for the research and development of children’s medication.
基金financial support from the National Natural Science Foundation of China(No.12474016)the program of“Distinguished Expert of Taishan Scholar”(No.tstp20221124)+4 种基金the National Natural Science Foundation of China(Nos.52172212,12474017)the Shandong Provincial Science Foundation(ZR2021YQ03)the program for“Young Scientists of Taishan Scholars”(No.tsqn202306184)financial support from the National Natural Science Foundation of China(No.12464034)the Natural Science Foundation of Ningxia,China(No.2024AAC05070)。
文摘Defect engineering is a commonly methodology used to enhance the thermoelectric performance of thermoelectric PbTe by improving its electronic transport properties.At the nanoscale,defects can induce quantum tunneling effects that significantly impact the electrical properties of materials.To understand the specific mechanisms underlying the quantum transport properties of PbTe,we employ the non-equilibrium Green's function(NEGF)method to investigate the effects of intrinsic defects(point defects and grain boundaries)on the electronic transport properties of PbTe-based nanodevices from a quantum mechanical perspective.Our results show that the Pb vacancy(VPb)has the highest conduction.The conduction depends on the defect type,chemical potential and bias voltage.The presence of intrinsic point defects introduces impurity levels,facilitating the electron tunneling and leading to an increase in the transmission coefficient,thereby enhancing the electronic transport properties.For PbTe containing grain boundaries,these boundaries suppress the electronic transport properties.The Te occupied twin boundary(Te-TB)exerts a stronger inhibitory effect than the Pb occupied twin boundary(Pb-TB).Nevertheless,the combined effect between twin boundaries and point defects can enhance the electrical properties.Therefore,in order to obtain highly conductive of PbTe materials,a Te-rich synthesis environment should be used to promote the effective formation of Pb vacancy.Our work offers a comprehensive understanding of the impact of defects on electron scattering in thermoelectric materials.
文摘Background:Against the backdrop of the complex interplay between global migration flows and the European Union’s governance system,immigrants’subjective well-being(SWB)has become a crucial indicator for assessing both their social integration and the effectiveness of integration policies.However,few studies have systematically linked immigration law and policy to SWB through a structured framework of human needs.This study aims to assess how European Union(EU)immigration policies influence immigrants’SWB by facilitating the fulfillment of hierarchical needs based on Maslow’s theory.Methods:Using data from the European Social Survey(ESS,2010–2023),this study analyzed 28,854 first-generation and second-generation immigrants across 24 EU member states.This study employed hierarchical regression models to assess the relative contribution of five levels of needs-physiological,safety,social,esteem,and self-actualization-in predicting life satisfaction and happiness,controlling for sociodemographic factors.Results:Safety needs-comprising perceived safety and institutional trust-produced the largest model improvement(ΔR^(2)≈0.06–0.07).Physiological needs(stable income and self-rated health)also had significant positive effect(β=0.06–0.25,p<0.001).Social and esteem needs showed moderate associations(β≈0.09–0.17,p<0.001),while self-actualization needs(education and union membership)displayed generational variation(β=0.02–0.10,p<0.01).Conclusion:This study not only validates the applicability of Maslow’s theory in migration research but also empirically establishes a policy hierarchy:ensuring physiological and safety needs as a foundation,supporting social and esteem needs,and enabling self-actualization pathways are essential for enhancing immigrant well-being.The findings offer valuable theoretical insights and practical guidance for refining immigrant integration policies within the EU’s multi-level governance structure.
基金supported by the National Natural Science Foundation of China(No.12461086)the Natural Science Foundation of Hubei Province(No.2022CFC016)。
文摘In this paper,we study a class of Sturm-Liouville problems,where the boundary conditions involve eigenparameters.Firstly,by defining a new inner product which depends on the transmission conditions,we obtain a new Hilbert space,on which the concerned operator A is self-adjoint.Then we construct the fundamental solutions to the problem,obtain the necessary and sufficient conditions for eigenvalues,and prove that the eigenvalues are simple.Finally,we investigate Green’s functions of such problem.
基金supported by the National Natural Science Foundation of China (Grant Nos. 12272269, 11972257,11832014 and 11472193)the Shanghai Pilot Program for Basic Researchthe Shanghai Gaofeng Project for University Academic Program Development。
文摘Understanding the effects of point liquid loading on transversely isotropic poroelastic media is crucial for advancing geomechanics and biomechanics, where precise modeling of fluid-structure interactions is essential. This paper presents a comprehensive analysis of infinite transversely isotropic poroelasticity under a fluid source, based on Biot's theory, aiming to uncover new and previously unexplored insights in the literature. We begin our study by deriving a general solution for fluid-saturated, transversely isotropic poroelastic materials in terms of harmonic functions that satisfy sixth-order homogeneous partial differential equations, using potential theory and Almansi's theorem. Based on these general solutions and potential functions, we construct a Green's function for a point fluid source, introducing three new harmonic functions with undetermined constants. These constants are determined by enforcing continuity and equilibrium conditions. Substituting these into the general solution yields fundamental solutions for poroelasticity that provide crucial support for a wide range of project problems. Numerical results and comparisons with existing literature are provided to illustrate physical mechanisms through contour plots. Our observations reveal that all components tend to zero in the far field and become singular at the concentrated source. Additionally, the contours exhibit rapid changes near the point fluid source but display gradual variations at a distance from it. These findings highlight the intricate behavior of the system under point liquid loading, offering valuable insights for further research and practical applications.
基金support provided by National Natural Science Foundation of China(22471018,22071008,22208018)support provided by the Shenzhen Science and Technology Program(JCYJ20220818100012025).
文摘Functionally graded materials (FGMs) are innovative materials distinguished by gradual variations in composition and structure, offering exceptional properties for diverse applications. Poly(ionic liquid)s (PILs), merging the characteristics of polymers and ionic liquids, have emerged as viable options for the development of FGMs given their tunable skeleton, ionic conductivity, and compatibility with various functional materials. This review highlights the latest advancements in the design strategies of FGMs based on porous PILs, focusing on single and multi-gradient structures. Furthermore, we also highlight their emerging applications in molecular recognition, sensing, adsorption, separation, and catalysis. By exploring the interplay between porosity, ionic functionality, and gradient architecture, this review offers perspectives on the prospects of PIL-based FGMs for tackling global challenges in energy, environment, and healthcare.
文摘Since the end of the Cold War,the core goal of U.S.policy toward Africa has been to build its influence on the continent through development assistance and trade preferences attached with political conditionalities,defined as“assistance for concessions”.After the September 11 attacks,counterterrorism became a priority in U.S.national security strategy,being one of the three pillars of U.S.policy toward Africa alongside assistance and trade.
基金supported by the National Natural Science Foundation of China(No.62304219)the Strategic Priority Research Program of theChinese Academy of Sciences(No.XDB43000000)+1 种基金the CAS Project for Young Scientists in Basic Research(YSBR−090)the National Natural ScienceFoundation of China(Nos.21975245,U20A20206,and 51972300)。
文摘Functionalization has emerged as a pivotal endeavor to tailor the surface properties of photocatalysts.We propose a facile amine functionalization strategy to establish a Cu−In−Zn−S(CIZS)/NiSx hybrid with covalent bonds using individual ethylenediamine(EDA)molecules.Our approach witnesses a remarkable photocatalytic hydrogen evolution(PHE)competence of 65.93 mmol g^(−1)h^(−1)driven by visible light,the highest value yielded by CIZS to date.X-ray absorption spectra of CIZS and density functional theory(DFT)calculations confirm the crucial amine N→Cu coordination after amine functionalization.The new emerging coordination via lone-pair electron donation profitably accesses the regulation of the coordination environment,electronic structures,and carrier behavior.Moreover,individual EDA molecule with two-terminal−NH2 group serves as a molecular bridge to hybrid CIZS and NiS_(x)cocatalyst via N→Cu and N→Ni coordination,favorably promoting efficient charge transport.This study provides advances in practical functionalizing photocatalysts.
基金supported by Shanghai 2021“Science and Technology Innovation Action Plan”:Social Development Science and Technology Research Project(Grant No.21DZ1202703).
文摘The numerical simulation of the fluid flow and the flexible rod(s)interaction is more complicated and has lower efficiency due to the high computational cost.In this paper,a semi-resolved model coupling the computational fluid dynamics and the flexible rod dynamics is proposed using a two-way domain expansion method.The gov-erning equations of the flexible rod dynamics are discretized and solved by the finite element method,and the fluid flow is simulated by the finite volume method.The interaction between fluids and solid rods is modeled by introducing body force terms into the momentum equations.Referred to the traditional semi-resolved numerical model,an anisotropic Gaussian kernel function method is proposed to specify the interactive forces between flu-ids and solid bodies for non-circle rod cross-sections.A benchmark of the flow passing around a single flexible plate with a rectangular cross-section is used to validate the algorithm.Focused on the engineering applications,a test case of a finite patch of cylinders is implemented to validate the accuracy and efficiency of the coupled model.
文摘We often hear statements like“the market raises expectations for central bank interest rate cuts,resulting in higher commodity prices”.Given the current situation,the People’s Bank of China might adopt a more accommodative monetary policy to mitigate the impact of the China-U.S.trade friction.Will this further easing of the monetary environment lead to an increase in natural gas prices?
基金the paper is the phased achievement of Projects of the National Social Science Foundation of China——“Study on the Supporting Policies in Limited Development Zones”(11BJL058) directed by the author
文摘As one of the important policies of promoting the formation of main functional areas, the industrial policy directly determines the sustainable growth of space control ability of main functional areas. A restricted development zone is a type of main functional area which provides agricultural products and ecological products, assures the supply of national agricultural products and the stability of ecosystems, as well as safeguards the ecological functions and agricultural functions of wider regions by restricting its own development. Therefore scientific, complete and operable industrial policy support is needed. Restricted development zones are distributed widely in western China. With the restriction of their main functions, differential industrial policies should be implemented in the development of the restricted development zones: Dealing well with the relationship between industrial development and ecological protection, developing special industries which are friendly to resources and environment and appropriate for local conditions, guiding and encouraging industries to learn from regions with favorable development conditions, orderly withdrawing industries and enterprises adverse to main functions, facilitating industrial structure upgrading, optimizing industrial organization, improving industrial technological level and rationalizing industrial layout.
文摘针对柔性直流输电系统(voltage source converter based high voltage direct current transmission,VSC-HVDC)控制参数设计过程中存在的鲁棒性差、依赖已知电路参数、工程设计经验化等问题,提出一种基于马尔科夫转换场(Markov transition field,MTF)与深度确定性策略梯度算法(deep deterministic policy gradient,DDPG)结合的鲁棒性强、不依赖电路参数特性以及可视化的VSC-HVDC控制参数优化设计方法。首先,采用马尔科夫转换场将电路功率、电压等一维时序波形数据转换为二维马尔科夫转换场域图像并使用马尔科夫转换场损失函数(Markov transition field loss,MTFL)判断二维转换域图的数据波动性;其次,将MTFL损失函数与DDPG算法相结合,综合利用MTFL损失函数对系统输出时序数据动态特性评价能力更强的优点和DDPG算法泛化性能优秀的特点,实现VSC-HVDC系统控制参数优化;最后,通过MATLAB模拟和实验结果验证该方法的有效性。
基金supported by CNSF(Granted No.40874050)Chinese High Technology Project(Granted No.2011YQ05006010)
文摘We present a method to unify the calculation of Green＇s functions for an electromagnetic（EM） transmitting source embedded in a homogeneous stratified medium.A virtual interface parallel to layer interfaces is introduced through the source location.The potentials for Green＇s function are derived by decomposing the partial wave solutions to Helmholtz＇s equations into upward and downward within boundaries.The amplitudes of the potentials in each stratum are obtained recursively from the initial amplitudes at the source level.The initial amplitudes are derived by coupling with the transmitting sources and following the discontinuity of the tangential electric and magnetic fields at the source interface.Only the initial terms are related to the transmitting sources and thus need to be modified for different transmitters,whereas the kernel connected with the stratified media stays unchanged.Hence,the present method can be easily applied to EM transmitting sources with little modification.The application of the proposed method to the marine controlled-source electromagnetic method（MCSEM） demonstrates its simplicity and flexibility.
基金Supported by Science and Technology Program of Shandong Province (No. 2010GHY10501)National Department Public Benefit Research Fond of China (No. 200909020)~~
文摘RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulated at three levels： transcription level, translation level and post-translational level. Environmental stress enters bacterial cells through signal transduction and leads to a series of variations in microenvironment, thereby causing changes of regulator and controlling its levels based on the direct and indirect interaction between regulator and RpoS protein. In addition, RpoS protein has played special roles in bacteria, therefore the changes of RpoS protein levels will lead to variations in expression levels of a large number of genes, thereby causing variations of bacterial response to different environmental stress and changes of certain characteristics of bacteria, which provides a new strategy for the control of bacterial diseases in the future. This paper reviewed the recent progress on the regulation of RpoS protein expression and its function in several common bacteria. Due to the functional complexity of RpoS protein, there are still a lot of unknown functions to be further identified.
