Objective To investigate whether Tuina alleviates fibrotic symptoms in myofascial trigger points(MTrPs)by regulating transforming growth factor(TGF)-β1/Smad3 signaling pathway,thereby deactivating these points.Method...Objective To investigate whether Tuina alleviates fibrotic symptoms in myofascial trigger points(MTrPs)by regulating transforming growth factor(TGF)-β1/Smad3 signaling pathway,thereby deactivating these points.Methods This study comprised two experimental phases.In phase 1,27 specific pathogenfree(SPF)grade female Sprague-Dawley(SD)rats were randomized into three groups:control 1,model 1,and Tuina 1 groups.Model 1 and Tuina 1 groups underwent an 8-week MTrPs modeling protocol involving blunt impact and eccentric exercise.After successful modeling,rats in Tuina 1 group received manual pressing on nodules or cord-like taut bands on the medial aspect of the left hindlimb.Pain sensitivity and tissue stiffness were evaluated via pressure pain threshold(PPT)and soft tissue tension(STT).Muscle histopathology and fibrosis were observed using hematoxylin and eosin(HE)and Masson staining.Inflammatory factors in muscle were measured by enzyme-linked immunosorbent assay(ELISA),while immunofluorescence(IF)and Western blot(WB)were used to detect the expression levels ofα-smooth muscle actin(α-SMA),collagenⅢ,and TGF-β1.In phase 2,45 SPF female SD rats were randomized into five groups:control 2,model 2,Tuina 2,TGF-β1 inhibitor(TI),and Tuina+TGF-β1 agonist(Tuina+TA)groups.All groups except control 2 underwent standardized MTrPs modeling.Rats in Tuina 2 group received consistent pressing manipulation.TI group received intraperitoneal injections of oxymatrine,while Tuina+TA group received intraperitoneal injections of SRI-011381 hydrochloride followed by the same pressing protocol as Tuina 2 group.WB was used to detect the expression of collagen I,collagen III,TGF-β1,and phosphorylated-Smad3(p-Smad3)/Smad3.Results In phase 1,Tuina significantly improved PPT and STT in MTrPs of rats(P<0.01),reversed pathological damages including disorganized muscle fiber arrangement,abnormal myocyte morphology,and exacerbated fibrosis.In addition,in MTrPs of rats in model 1 group,expression levels of nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB),interleukin(IL)-1β,IL-6,tumor necrosis factor(TNF)-α,and fibrosis markers(α-SMA,collagen I,and collagen III)were upregulated,and all exhibited a significant downward trend after Tuina intervention(P<0.05 or P<0.01).This indicates that the therapeutic effects of Tuina are directly associated with reduced local inflammation and fibrosis in MTrPs.In phase 2,compared with model 2 group,rats in TI and Tuina 2 groups had decreased expression levels of TGF-β1 and p-Smad3/Smad3 in MTrPs,alongside reduced levels of inflammatory factors(IL-1β,IL-6,NF-κB,and TNF-α)and fibrosis markers(α-SMA,collagen I,and collagen III)(P<0.05 or P<0.01).When co-administered with TGF-β1 agonist,the therapeutic effects of Tuina were significantly attenuated,with rebounded TGF-β1 expression and p-Smad3/Smad3 in local MTrPs,and fibrosis and inflammatory responses were re-exacerbated(P<0.05 or P<0.01).Conclusion Tuina can effectively reduce inflammatory responses and fibrosis in MTrPs tissue,and its mechanism is closely related to the inhibition of the TGF-β1/Smad3 signaling pathway,which plays a critical role in Tuina-mediated regulation of MTrPs fibrosis.展开更多
Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewa...Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.展开更多
The automatic loading systems of artillery are critical for the accurate,efficient,and reliable delivery of pro-jectiles and propellants into the gun chamber.In modern artillery,the ammunition conveyor serves as the e...The automatic loading systems of artillery are critical for the accurate,efficient,and reliable delivery of pro-jectiles and propellants into the gun chamber.In modern artillery,the ammunition conveyor serves as the end effector of the automatic loading system,and its motion state significantly impacts the accuracy of projectiles.Therefore,it is of immense importance to precisely and effectively evaluate the reliability of the motion accuracy of the ammunition conveyor.This paper aims to propose a practical and efficient analysis method for evaluating the reliability of the motion accuracy of the ammunition conveyor.The proposed approach involves the use of a deep learning network to approximate the physical model and the extremum method to obtain a single cycle sequence decoupling strategy for solving the time-varying reliability issue of complex systems.Employing this strategy,the time-varying reliability of the ammunition conveyor is transformed into a static reliability problem.The proposed method includes the use of a deep feedforward neural network,second-order saddle point ap-proximation(SPA)method,extremum method,and efficient global optimization(EGO)technology.The results reveal that the reliability of the motion accuracy of the ammunition conveyor is 93.42%,with the maximum failure probability occurring at 0.21 s.These results serve as an important reference for the structural optimi-zation design of the ammunition conveyor based on reliability and the maintenance of the operational process.展开更多
3D laser scanning technology is widely used in underground openings for high-precision,rapid,and nondestructive structural evaluations.Segmenting large 3D point cloud datasets,particularly in coal mine roadways with m...3D laser scanning technology is widely used in underground openings for high-precision,rapid,and nondestructive structural evaluations.Segmenting large 3D point cloud datasets,particularly in coal mine roadways with multi-scale targets,remains challenging.This paper proposes an enhanced segmentation method integrating improved PointNet++with a coverage-voted strategy.The coverage-voted strategy reduces data while preserving multi-scale target topology.The segmentation is achieved using an enhanced PointNet++algorithm with a normalization preprocessing head,resulting in a 94%accuracy for common supporting components.Ablation experiments show that the preprocessing head and coverage strategies increase segmentation accuracy by 20%and 2%,respectively,and improve Intersection over Union(IoU)for bearing plate segmentation by 58%and 20%.The accuracy of the current pretraining segmentation model may be affected by variations in surface support components,but it can be readily enhanced through re-optimization with additional labeled point cloud data.This proposed method,combined with a previously developed machine learning model that links rock bolt load and the deformation field of its bearing plate,provides a robust technique for simultaneously measuring the load of multiple rock bolts in a single laser scan.展开更多
AIM:To construct an intelligent segmentation scheme for precise localization of central serous chorioretinopathy(CSC)leakage points,thereby enabling ophthalmologists to deliver accurate laser treatment without navigat...AIM:To construct an intelligent segmentation scheme for precise localization of central serous chorioretinopathy(CSC)leakage points,thereby enabling ophthalmologists to deliver accurate laser treatment without navigational laser equipment.METHODS:A dataset with dual labels(point-level and pixel-level)was first established based on fundus fluorescein angiography(FFA)images of CSC and subsequently divided into training(102 images),validation(40 images),and test(40 images)datasets.An intelligent segmentation method was then developed,based on the You Only Look Once version 8 Pose Estimation(YOLOv8-Pose)model and segment anything model(SAM),to segment CSC leakage points.Next,the YOLOv8-Pose model was trained for 200 epochs,and the best-performing model was selected to form the optimal combination with SAM.Additionally,the classic five types of U-Net series models[i.e.,U-Net,recurrent residual U-Net(R2U-Net),attention U-Net(AttU-Net),recurrent residual attention U-Net(R2AttUNet),and nested U-Net(UNet^(++))]were initialized with three random seeds and trained for 200 epochs,resulting in a total of 15 baseline models for comparison.Finally,based on the metrics including Dice similarity coefficient(DICE),intersection over union(IoU),precision,recall,precisionrecall(PR)curve,and receiver operating characteristic(ROC)curve,the proposed method was compared with baseline models through quantitative and qualitative experiments for leakage point segmentation,thereby demonstrating its effectiveness.RESULTS:With the increase of training epochs,the mAP50-95,Recall,and precision of the YOLOv8-Pose model showed a significant increase and tended to stabilize,and it achieved a preliminary localization success rate of 90%(i.e.,36 images)for CSC leakage points in 40 test images.Using manually expert-annotated pixel-level labels as the ground truth,the proposed method achieved outcomes with a DICE of 57.13%,an IoU of 45.31%,a precision of 45.91%,a recall of 93.57%,an area under the PR curve(AUC-PR)of 0.78 and an area under the ROC curve(AUC-ROC)of 0.97,which enables more accurate segmentation of CSC leakage points.CONCLUSION:By combining the precise localization capability of the YOLOv8-Pose model with the robust and flexible segmentation ability of SAM,the proposed method not only demonstrates the effectiveness of the YOLOv8-Pose model in detecting keypoint coordinates of CSC leakage points from the perspective of application innovation but also establishes a novel approach for accurate segmentation of CSC leakage points through the“detect-then-segment”strategy,thereby providing a potential auxiliary means for the automatic and precise realtime localization of leakage points during traditional laser photocoagulation for CSC.展开更多
Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and ...Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and Conclusion The criteria for singular points, closed orbits and hyperbolic equilibrium points of a second order autonomous Birkhoff system are given. Moreover the stability of equilibria, stable manifolds and unstable manifolds are obtained.展开更多
Objective:This study aimed to develop expert fuzzy logic model to assist physicians in the prediction of postoperative complications of prostatic hyperplasia before surgery.Methods:A method for classification of surgi...Objective:This study aimed to develop expert fuzzy logic model to assist physicians in the prediction of postoperative complications of prostatic hyperplasia before surgery.Methods:A method for classification of surgical risks was developed.The effect of rotation of the current–voltage characteristics at biologically active points(acupuncture points)was used for the formation of classifier descriptors.The effect determined reversible and non-reversible changes in electrical resistance at acupuncture points with periodic exposure to a sawtooth probe current.Then,the developed method was tested on the prediction of the success of surgical treatment of benign prostatic hyperplasia.Results:Input descriptors were obtained from collected data including current-voltage characteristics of 5 acupuncture points and composed of 27 arrays feeding in the model.The maximum diagnostic sensitivity of the classifier for the success of a surgical operation in the control sample was 88%and for testing data set prediction accuracy was 97%.Conclusion:The use of tuples of current-voltage characteristic descriptors of acupuncture points in the classifiers could be used to predict the success of surgical treatment with satisfactory accuracy.The model can be a valuable tool to support physicians’diagnosis.展开更多
This paper studies the regional stability for positive switched linear systems with multi-equilibrium points （PSLS-MEP）. First, a sufficient condition is presented for the regional stability of PSLS-MEP via a common...This paper studies the regional stability for positive switched linear systems with multi-equilibrium points （PSLS-MEP）. First, a sufficient condition is presented for the regional stability of PSLS-MEP via a common linear Lyapunov function. Second, by establishing multiple Lyapunov functions, a dwell time based condition is proposed for the regional stability analysis. Third, a suprasphere which contains all equilibrium points is constructed as a stability region of the considered PSLS-MEP, which is less conservative than existing results. Finally, the study of an illustrative example shows that the obtained results are effective in the regional stability analysis of PSLS-MEP.展开更多
As-east mierostruetures and their distribution of Mg-Zn-Y ternary alloy with high magnesium, low zinc and yttrium were examined using Nikon Epiphot optical microscopy （OM）, RigakuD/max-3C X- ray diffraetion （XRD）,...As-east mierostruetures and their distribution of Mg-Zn-Y ternary alloy with high magnesium, low zinc and yttrium were examined using Nikon Epiphot optical microscopy （OM）, RigakuD/max-3C X- ray diffraetion （XRD）, and JEOL JSM-6700F scanning electron microscopy （SEM） equipped with an energydispersive X-ray spectroscopy （EDS）. In the as-east mierostructures, Yttrium and zinc tend to segregate at grain boundaries,展开更多
Making use of the Z2×Z2 symmetry,we could study the structure near multiple S-treaking turning points.In particular,we show that there exist two kinds of singular point path through double S breaking turning poin...Making use of the Z2×Z2 symmetry,we could study the structure near multiple S-treaking turning points.In particular,we show that there exist two kinds of singular point path through double S breaking turning points and triple S bieaking turning points,one ts quadratic turning pornt path and one is quadratic pitch fork bifurcation point path.Some simple regular extended systems to corn pute double and triple S-breaking turning points are proposed.Numerical examples are also展开更多
Two-dimensional systems with chiral symmetry allow stable discrete band crossings(nodal points) in Brillouin zones.Here we study the local evolutions of these nodal points under chiral symmetry preserving perturbation...Two-dimensional systems with chiral symmetry allow stable discrete band crossings(nodal points) in Brillouin zones.Here we study the local evolutions of these nodal points under chiral symmetry preserving perturbations.We find that these evolutions can be classified by different types of local k·p models around the nodal points.Several concrete examples are calculated to illustrate our results.展开更多
Discuss a class of real planar cubic systems with a critical point O (0,0) of nine orders and obtain the conditions for its limit cycle surrounding the origin, and prove that when small pertubations of coefficients ar...Discuss a class of real planar cubic systems with a critical point O (0,0) of nine orders and obtain the conditions for its limit cycle surrounding the origin, and prove that when small pertubations of coefficients are made, the critical point O (0,0) of nine orders is split into nine real simple critical points and the limit cycle surrounding the origin becomes the limit cycle containing nine critical points in its interior.展开更多
For a class of manufacturing systems with homogeneous Markov machine failure rates,the stationary probability distribution of the part surplus can be calculated for given tentative values of hedging points. Some prope...For a class of manufacturing systems with homogeneous Markov machine failure rates,the stationary probability distribution of the part surplus can be calculated for given tentative values of hedging points. Some properties on the ordering of optimal hedging points are obtained.展开更多
Under some certain assumptions, the physical model of the air combustion system was simplified to a laminar flame system. The mathematical model of the laminar flame system, which was built according to thermodynamics...Under some certain assumptions, the physical model of the air combustion system was simplified to a laminar flame system. The mathematical model of the laminar flame system, which was built according to thermodynamics theory and the corresponding conservative laws, was studied. With the aid of qualitative theory and method of ordinary differential equations, the location of singular points on the Rayleigh curves is determined, the qualitative structure and the stability of the singular points of the laminar flame system, which are located in the areas of deflagration and detonation, are given for different parameter values and uses of combustion. The phase portraits of the laminar flame system in the reaction-stagnation enthalpy and combustion velocity-stagnation enthalpy planes are shown in the corresponding figures.展开更多
We study the exceptional-point(EP) structure and the associated quantum dynamics in a system consisting of a non-Hermitian qubit and a Hermitian qubit. We find that the system possesses two sets of EPs, which divide t...We study the exceptional-point(EP) structure and the associated quantum dynamics in a system consisting of a non-Hermitian qubit and a Hermitian qubit. We find that the system possesses two sets of EPs, which divide the systemparameter space into PT-symmetry unbroken, partially broken and fully broken regimes, each with distinct quantumdynamics characteristics. Particularly, in the partially broken regime, while the PT-symmetry is generally broken in the whole four-dimensional Hilbert space, it is preserved in a two-dimensional subspace such that the quantum dynamics in the subspace are similar to those in the PT-symmetry unbroken regime. In addition, we reveal that the competition between the inter-qubit coupling and the intra-qubit driving gives rise to a complex pattern in the EP variation with system parameters.展开更多
In this paper foe bifurcation of critical points for the quadratic systems of type(II)and (III) is investigated. and an answer to the problem given in[1] is given.
In this paper,we establish some common fixed point theorems and stability theorems of the sets of common fixed points for the systems of set-valued and single-valued nonlinear contractive type mappings in a finite Car...In this paper,we establish some common fixed point theorems and stability theorems of the sets of common fixed points for the systems of set-valued and single-valued nonlinear contractive type mappings in a finite Cartesian product of metric spaces.展开更多
A chaotic system with various equilibrium types has rich dynamic behaviors.Its state can switch flexibly among different families of attractors,which is beneficial to the practical applications.So it has been widely c...A chaotic system with various equilibrium types has rich dynamic behaviors.Its state can switch flexibly among different families of attractors,which is beneficial to the practical applications.So it has been widely concerned in recent years.In this paper,a new 5D hyper-chaotic system is proposed.The important characteristic of the system is that it may have multiple types of equilibrium points by changing system parameters,namely,linear equilibrium point,no equilibrium point,non-hyperbolic unstable equilibrium point and stable hyperbolictype equilibrium point.Furthermore,there are hyper-chaotic phenomena and multi-stability about the coexistence of multiple chaotic attractors and the coexistence of hyper-chaotic attractors and chaotic attractors in the system.In addition,the system,complexity is analyzed.It is found that the complexity is close to 1 in the hyper-chaotic state and a pseudo-random sequence generated by the system passes all the statistical tests.Finally,an analog circuit of the system is designed and simulated.展开更多
In this paper we consider the asymptotic behavior of boundary value problems of nonliner systems εy″= F(t,y,y′,ε) , -1<t<1, y(-1,ε)=A, y(1,ε)=B when F possesses a generalized turning point at t...In this paper we consider the asymptotic behavior of boundary value problems of nonliner systems εy″= F(t,y,y′,ε) , -1<t<1, y(-1,ε)=A, y(1,ε)=B when F possesses a generalized turning point at t=0. The interior layer phenomenon of the problem is discussed.展开更多
Mottness is at the heart of the essential physics in a strongly correlated system as many novel quantum phenomena occur in the metallic phase near the Mott metal–insulator transition. We investigate the Mott transiti...Mottness is at the heart of the essential physics in a strongly correlated system as many novel quantum phenomena occur in the metallic phase near the Mott metal–insulator transition. We investigate the Mott transition in a Hubbard model by using the dynamical mean-field theory and introduce the local quantum state fidelity to depict the Mott metal–insulator transition. The local quantum state fidelity provides a convenient approach to determining the critical point of the Mott transition. Additionally, it presents a consistent description of the two distinct forms of the Mott transition points.展开更多
基金Natural Science Foundation of China(82274676 and 82374613)Program of Hunan Provincial Natural Science(2023JJ30458).
文摘Objective To investigate whether Tuina alleviates fibrotic symptoms in myofascial trigger points(MTrPs)by regulating transforming growth factor(TGF)-β1/Smad3 signaling pathway,thereby deactivating these points.Methods This study comprised two experimental phases.In phase 1,27 specific pathogenfree(SPF)grade female Sprague-Dawley(SD)rats were randomized into three groups:control 1,model 1,and Tuina 1 groups.Model 1 and Tuina 1 groups underwent an 8-week MTrPs modeling protocol involving blunt impact and eccentric exercise.After successful modeling,rats in Tuina 1 group received manual pressing on nodules or cord-like taut bands on the medial aspect of the left hindlimb.Pain sensitivity and tissue stiffness were evaluated via pressure pain threshold(PPT)and soft tissue tension(STT).Muscle histopathology and fibrosis were observed using hematoxylin and eosin(HE)and Masson staining.Inflammatory factors in muscle were measured by enzyme-linked immunosorbent assay(ELISA),while immunofluorescence(IF)and Western blot(WB)were used to detect the expression levels ofα-smooth muscle actin(α-SMA),collagenⅢ,and TGF-β1.In phase 2,45 SPF female SD rats were randomized into five groups:control 2,model 2,Tuina 2,TGF-β1 inhibitor(TI),and Tuina+TGF-β1 agonist(Tuina+TA)groups.All groups except control 2 underwent standardized MTrPs modeling.Rats in Tuina 2 group received consistent pressing manipulation.TI group received intraperitoneal injections of oxymatrine,while Tuina+TA group received intraperitoneal injections of SRI-011381 hydrochloride followed by the same pressing protocol as Tuina 2 group.WB was used to detect the expression of collagen I,collagen III,TGF-β1,and phosphorylated-Smad3(p-Smad3)/Smad3.Results In phase 1,Tuina significantly improved PPT and STT in MTrPs of rats(P<0.01),reversed pathological damages including disorganized muscle fiber arrangement,abnormal myocyte morphology,and exacerbated fibrosis.In addition,in MTrPs of rats in model 1 group,expression levels of nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB),interleukin(IL)-1β,IL-6,tumor necrosis factor(TNF)-α,and fibrosis markers(α-SMA,collagen I,and collagen III)were upregulated,and all exhibited a significant downward trend after Tuina intervention(P<0.05 or P<0.01).This indicates that the therapeutic effects of Tuina are directly associated with reduced local inflammation and fibrosis in MTrPs.In phase 2,compared with model 2 group,rats in TI and Tuina 2 groups had decreased expression levels of TGF-β1 and p-Smad3/Smad3 in MTrPs,alongside reduced levels of inflammatory factors(IL-1β,IL-6,NF-κB,and TNF-α)and fibrosis markers(α-SMA,collagen I,and collagen III)(P<0.05 or P<0.01).When co-administered with TGF-β1 agonist,the therapeutic effects of Tuina were significantly attenuated,with rebounded TGF-β1 expression and p-Smad3/Smad3 in local MTrPs,and fibrosis and inflammatory responses were re-exacerbated(P<0.05 or P<0.01).Conclusion Tuina can effectively reduce inflammatory responses and fibrosis in MTrPs tissue,and its mechanism is closely related to the inhibition of the TGF-β1/Smad3 signaling pathway,which plays a critical role in Tuina-mediated regulation of MTrPs fibrosis.
基金supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(CI2021A04013)the National Natural Science Foundation of China(82204610)+1 种基金the Qihang Talent Program(L2022046)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.
基金Supported by National Natural Science Foundation of China(Grant No.U2141246)Key Laboratory of Artillery Launch and Control Technology of China(Grant No.2021-001)Basic Research of State Administration of Science Technology and Industry for National Defense of China(Grant No.JXJL202208A001).
文摘The automatic loading systems of artillery are critical for the accurate,efficient,and reliable delivery of pro-jectiles and propellants into the gun chamber.In modern artillery,the ammunition conveyor serves as the end effector of the automatic loading system,and its motion state significantly impacts the accuracy of projectiles.Therefore,it is of immense importance to precisely and effectively evaluate the reliability of the motion accuracy of the ammunition conveyor.This paper aims to propose a practical and efficient analysis method for evaluating the reliability of the motion accuracy of the ammunition conveyor.The proposed approach involves the use of a deep learning network to approximate the physical model and the extremum method to obtain a single cycle sequence decoupling strategy for solving the time-varying reliability issue of complex systems.Employing this strategy,the time-varying reliability of the ammunition conveyor is transformed into a static reliability problem.The proposed method includes the use of a deep feedforward neural network,second-order saddle point ap-proximation(SPA)method,extremum method,and efficient global optimization(EGO)technology.The results reveal that the reliability of the motion accuracy of the ammunition conveyor is 93.42%,with the maximum failure probability occurring at 0.21 s.These results serve as an important reference for the structural optimi-zation design of the ammunition conveyor based on reliability and the maintenance of the operational process.
基金supported by the National Natural Science Foundation of China(Grant Nos.52304139,52325403)the CCTEG Coal Mining Research Institute funding(Grant No.KCYJY-2024-MS-10).
文摘3D laser scanning technology is widely used in underground openings for high-precision,rapid,and nondestructive structural evaluations.Segmenting large 3D point cloud datasets,particularly in coal mine roadways with multi-scale targets,remains challenging.This paper proposes an enhanced segmentation method integrating improved PointNet++with a coverage-voted strategy.The coverage-voted strategy reduces data while preserving multi-scale target topology.The segmentation is achieved using an enhanced PointNet++algorithm with a normalization preprocessing head,resulting in a 94%accuracy for common supporting components.Ablation experiments show that the preprocessing head and coverage strategies increase segmentation accuracy by 20%and 2%,respectively,and improve Intersection over Union(IoU)for bearing plate segmentation by 58%and 20%.The accuracy of the current pretraining segmentation model may be affected by variations in surface support components,but it can be readily enhanced through re-optimization with additional labeled point cloud data.This proposed method,combined with a previously developed machine learning model that links rock bolt load and the deformation field of its bearing plate,provides a robust technique for simultaneously measuring the load of multiple rock bolts in a single laser scan.
基金Supported by the Shenzhen Science and Technology Program(No.JCYJ20240813152704006)the National Natural Science Foundation of China(No.62401259)+2 种基金the Fundamental Research Funds for the Central Universities(No.NZ2024036)the Postdoctoral Fellowship Program of CPSF(No.GZC20242228)High Performance Computing Platform of Nanjing University of Aeronautics and Astronautics。
文摘AIM:To construct an intelligent segmentation scheme for precise localization of central serous chorioretinopathy(CSC)leakage points,thereby enabling ophthalmologists to deliver accurate laser treatment without navigational laser equipment.METHODS:A dataset with dual labels(point-level and pixel-level)was first established based on fundus fluorescein angiography(FFA)images of CSC and subsequently divided into training(102 images),validation(40 images),and test(40 images)datasets.An intelligent segmentation method was then developed,based on the You Only Look Once version 8 Pose Estimation(YOLOv8-Pose)model and segment anything model(SAM),to segment CSC leakage points.Next,the YOLOv8-Pose model was trained for 200 epochs,and the best-performing model was selected to form the optimal combination with SAM.Additionally,the classic five types of U-Net series models[i.e.,U-Net,recurrent residual U-Net(R2U-Net),attention U-Net(AttU-Net),recurrent residual attention U-Net(R2AttUNet),and nested U-Net(UNet^(++))]were initialized with three random seeds and trained for 200 epochs,resulting in a total of 15 baseline models for comparison.Finally,based on the metrics including Dice similarity coefficient(DICE),intersection over union(IoU),precision,recall,precisionrecall(PR)curve,and receiver operating characteristic(ROC)curve,the proposed method was compared with baseline models through quantitative and qualitative experiments for leakage point segmentation,thereby demonstrating its effectiveness.RESULTS:With the increase of training epochs,the mAP50-95,Recall,and precision of the YOLOv8-Pose model showed a significant increase and tended to stabilize,and it achieved a preliminary localization success rate of 90%(i.e.,36 images)for CSC leakage points in 40 test images.Using manually expert-annotated pixel-level labels as the ground truth,the proposed method achieved outcomes with a DICE of 57.13%,an IoU of 45.31%,a precision of 45.91%,a recall of 93.57%,an area under the PR curve(AUC-PR)of 0.78 and an area under the ROC curve(AUC-ROC)of 0.97,which enables more accurate segmentation of CSC leakage points.CONCLUSION:By combining the precise localization capability of the YOLOv8-Pose model with the robust and flexible segmentation ability of SAM,the proposed method not only demonstrates the effectiveness of the YOLOv8-Pose model in detecting keypoint coordinates of CSC leakage points from the perspective of application innovation but also establishes a novel approach for accurate segmentation of CSC leakage points through the“detect-then-segment”strategy,thereby providing a potential auxiliary means for the automatic and precise realtime localization of leakage points during traditional laser photocoagulation for CSC.
文摘Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and Conclusion The criteria for singular points, closed orbits and hyperbolic equilibrium points of a second order autonomous Birkhoff system are given. Moreover the stability of equilibria, stable manifolds and unstable manifolds are obtained.
基金supported by the Russian Foundation for Basic Research(RFBR),project number 19–38-90116。
文摘Objective:This study aimed to develop expert fuzzy logic model to assist physicians in the prediction of postoperative complications of prostatic hyperplasia before surgery.Methods:A method for classification of surgical risks was developed.The effect of rotation of the current–voltage characteristics at biologically active points(acupuncture points)was used for the formation of classifier descriptors.The effect determined reversible and non-reversible changes in electrical resistance at acupuncture points with periodic exposure to a sawtooth probe current.Then,the developed method was tested on the prediction of the success of surgical treatment of benign prostatic hyperplasia.Results:Input descriptors were obtained from collected data including current-voltage characteristics of 5 acupuncture points and composed of 27 arrays feeding in the model.The maximum diagnostic sensitivity of the classifier for the success of a surgical operation in the control sample was 88%and for testing data set prediction accuracy was 97%.Conclusion:The use of tuples of current-voltage characteristic descriptors of acupuncture points in the classifiers could be used to predict the success of surgical treatment with satisfactory accuracy.The model can be a valuable tool to support physicians’diagnosis.
基金supported by National Natural Science Foundation of China(No.61374065)the Research Fund for the Taishan Scholar Project of Shandong Province
文摘This paper studies the regional stability for positive switched linear systems with multi-equilibrium points （PSLS-MEP）. First, a sufficient condition is presented for the regional stability of PSLS-MEP via a common linear Lyapunov function. Second, by establishing multiple Lyapunov functions, a dwell time based condition is proposed for the regional stability analysis. Third, a suprasphere which contains all equilibrium points is constructed as a stability region of the considered PSLS-MEP, which is less conservative than existing results. Finally, the study of an illustrative example shows that the obtained results are effective in the regional stability analysis of PSLS-MEP.
文摘As-east mierostruetures and their distribution of Mg-Zn-Y ternary alloy with high magnesium, low zinc and yttrium were examined using Nikon Epiphot optical microscopy （OM）, RigakuD/max-3C X- ray diffraetion （XRD）, and JEOL JSM-6700F scanning electron microscopy （SEM） equipped with an energydispersive X-ray spectroscopy （EDS）. In the as-east mierostructures, Yttrium and zinc tend to segregate at grain boundaries,
基金This work is supported by NSFC amd Slate Major Key Project for Baslc Research
文摘Making use of the Z2×Z2 symmetry,we could study the structure near multiple S-treaking turning points.In particular,we show that there exist two kinds of singular point path through double S breaking turning points and triple S bieaking turning points,one ts quadratic turning pornt path and one is quadratic pitch fork bifurcation point path.Some simple regular extended systems to corn pute double and triple S-breaking turning points are proposed.Numerical examples are also
基金Project supported by the National Basic Research Program of China(Grant Nos.2015CB921300 and 2017YFA0303100)the National Natural Science Foundation of China(Grant Nos.1190020,11534014,and 11334012)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant Nos.XDB07000000 and XDB28000000)
文摘Two-dimensional systems with chiral symmetry allow stable discrete band crossings(nodal points) in Brillouin zones.Here we study the local evolutions of these nodal points under chiral symmetry preserving perturbations.We find that these evolutions can be classified by different types of local k·p models around the nodal points.Several concrete examples are calculated to illustrate our results.
基金The Natural Science Foundation of Hunan Province !(No .97JJN 70 )
文摘Discuss a class of real planar cubic systems with a critical point O (0,0) of nine orders and obtain the conditions for its limit cycle surrounding the origin, and prove that when small pertubations of coefficients are made, the critical point O (0,0) of nine orders is split into nine real simple critical points and the limit cycle surrounding the origin becomes the limit cycle containing nine critical points in its interior.
文摘For a class of manufacturing systems with homogeneous Markov machine failure rates,the stationary probability distribution of the part surplus can be calculated for given tentative values of hedging points. Some properties on the ordering of optimal hedging points are obtained.
基金theNaturalScienceFoundationofBeijingMunicipalGovernment (No .1 0 42 0 0 7)andtheScientificResearchFoundationfortheReturnedOverseasChineseScholars,StateEducationMinistry (No .Lxkyjj2 0 0 41 6)
文摘Under some certain assumptions, the physical model of the air combustion system was simplified to a laminar flame system. The mathematical model of the laminar flame system, which was built according to thermodynamics theory and the corresponding conservative laws, was studied. With the aid of qualitative theory and method of ordinary differential equations, the location of singular points on the Rayleigh curves is determined, the qualitative structure and the stability of the singular points of the laminar flame system, which are located in the areas of deflagration and detonation, are given for different parameter values and uses of combustion. The phase portraits of the laminar flame system in the reaction-stagnation enthalpy and combustion velocity-stagnation enthalpy planes are shown in the corresponding figures.
基金partly funded by the Natural Science Foundation of Shandong Province of China (Grant Nos. ZR2021MA091 and ZR2018MA044)Introduction and Cultivation Plan of Youth Innovation Talents for Universities of Shandong Province (Research and Innovation Team on Materials Modification and Optoelectronic Devices at extreme conditions)。
文摘We study the exceptional-point(EP) structure and the associated quantum dynamics in a system consisting of a non-Hermitian qubit and a Hermitian qubit. We find that the system possesses two sets of EPs, which divide the systemparameter space into PT-symmetry unbroken, partially broken and fully broken regimes, each with distinct quantumdynamics characteristics. Particularly, in the partially broken regime, while the PT-symmetry is generally broken in the whole four-dimensional Hilbert space, it is preserved in a two-dimensional subspace such that the quantum dynamics in the subspace are similar to those in the PT-symmetry unbroken regime. In addition, we reveal that the competition between the inter-qubit coupling and the intra-qubit driving gives rise to a complex pattern in the EP variation with system parameters.
文摘In this paper foe bifurcation of critical points for the quadratic systems of type(II)and (III) is investigated. and an answer to the problem given in[1] is given.
文摘In this paper,we establish some common fixed point theorems and stability theorems of the sets of common fixed points for the systems of set-valued and single-valued nonlinear contractive type mappings in a finite Cartesian product of metric spaces.
基金the Science Foundation of Ministry of Education of China(No.02152)。
文摘A chaotic system with various equilibrium types has rich dynamic behaviors.Its state can switch flexibly among different families of attractors,which is beneficial to the practical applications.So it has been widely concerned in recent years.In this paper,a new 5D hyper-chaotic system is proposed.The important characteristic of the system is that it may have multiple types of equilibrium points by changing system parameters,namely,linear equilibrium point,no equilibrium point,non-hyperbolic unstable equilibrium point and stable hyperbolictype equilibrium point.Furthermore,there are hyper-chaotic phenomena and multi-stability about the coexistence of multiple chaotic attractors and the coexistence of hyper-chaotic attractors and chaotic attractors in the system.In addition,the system,complexity is analyzed.It is found that the complexity is close to 1 in the hyper-chaotic state and a pseudo-random sequence generated by the system passes all the statistical tests.Finally,an analog circuit of the system is designed and simulated.
文摘In this paper we consider the asymptotic behavior of boundary value problems of nonliner systems εy″= F(t,y,y′,ε) , -1<t<1, y(-1,ε)=A, y(1,ε)=B when F possesses a generalized turning point at t=0. The interior layer phenomenon of the problem is discussed.
基金Project supported by the Scientific Research Foundation for Youth Academic Talent of Inner Mongolia University (Grant No.1000023112101/010)the Fundamental Research Funds for the Central Universities of China (Grant No.JN200208)+2 种基金supported by the National Natural Science Foundation of China (Grant No.11474023)supported by the National Key Research and Development Program of China (Grant No.2021YFA1401803)the National Natural Science Foundation of China (Grant Nos.11974051 and 11734002)。
文摘Mottness is at the heart of the essential physics in a strongly correlated system as many novel quantum phenomena occur in the metallic phase near the Mott metal–insulator transition. We investigate the Mott transition in a Hubbard model by using the dynamical mean-field theory and introduce the local quantum state fidelity to depict the Mott metal–insulator transition. The local quantum state fidelity provides a convenient approach to determining the critical point of the Mott transition. Additionally, it presents a consistent description of the two distinct forms of the Mott transition points.
