Monkeypox virus(MPXV),a member of the Orthopoxvirus genus,caused a large-scale global outbreak in 2022.Developing mouse models for MPXV infection is crucial for advancing research on vaccines and therapeutic intervent...Monkeypox virus(MPXV),a member of the Orthopoxvirus genus,caused a large-scale global outbreak in 2022.Developing mouse models for MPXV infection is crucial for advancing research on vaccines and therapeutic interventions.To address this,we conducted a comparative study on the susceptibility of six mouse strains—severe combined immune-deficiency(SCID),nude,genetically diabetic(db/db)and obese(ob/ob),C57BL/6J,and BALB/c—to MPXV infection.Mouse strains were infected with MPXV via intranasal inoculation,and body weight changes and mortality were monitored post-infection.Additionally,the tissue distribution of MPXV and the pathological changes in the lung tissues of the infected mice were evaluated.The results demonstrated that SCID and nude mice exhibited significant weight loss following MPXV infection,with 100%mortality observed in SCID mice,while no mortality occurred in nude mice.In contrast,the other mouse strains showed no significant weight loss or mortality.Notably,the viral load in the lung tissues of SCID and nude mice was the highest among the tested strains.Furthermore,we investigated the impact of different inoculation routes—intranasal(I.N.),intraperitoneal(I.P.),and intravenous(I.V.)—on the pathogenicity of MPXV in mice.The results revealed that the intravenous route induced more pronounced pathogenic effects compared to the intranasal and intraperitoneal routes.In summary,this study provides valuable insights into the development of MPXV-infected mouse models,offering a foundation for further research on MPXV pathogenesis and therapeutic drug development.展开更多
Microstructure and mechanical properties of aged Mg-10Gd-2Y-0.4Zr-0.4Ag alloy sheets prepared by different rolling routes were investigated.The results showed that the cross rolling aged(CRA)sheet possesses larger gra...Microstructure and mechanical properties of aged Mg-10Gd-2Y-0.4Zr-0.4Ag alloy sheets prepared by different rolling routes were investigated.The results showed that the cross rolling aged(CRA)sheet possesses larger grain size than unidirectional rolling aged(URA)sheet due to the occurrence of dynamic recovery during rolling which reduces the dislocation density and delays dynamic recrystallization(DRX).The URA sheet has basal texture and RD favored texture while CRA sheet has multiple-peak texture.Both sheets precipitate β'phase and CRA sheet exhibits a stronger aging response.The CRA sheet has higher yield strength and tensile strength than URA sheet,with reduced yield strength anisotropy but increased tensile strength anisotropy.Taking into account different strengthening mechanisms,although the finer grain size of URA sheet enhances grain boundary strengthening,CRA sheet is more responsive to aging,leading to superior aging-precipitated phase strengthening and consequently higher yield strength.展开更多
Meta-heuristic evolutionary algorithms have become widely used for solving complex optimization problems.However,their effectiveness in real-world applications is often limited by the need for many evaluations,which c...Meta-heuristic evolutionary algorithms have become widely used for solving complex optimization problems.However,their effectiveness in real-world applications is often limited by the need for many evaluations,which can be both costly and time-consuming.This is especially true for large-scale transportation networks,where the size of the problem and the high computational cost can hinder the algorithm’s performance.To address these challenges,recent research has focused on using surrogate-assisted models.These models aim to reduce the number of expensive evaluations and improve the efficiency of solving time-consuming optimization problems.This paper presents a new two-layer Surrogate-Assisted Fish Migration Optimization(SA-FMO)algorithm designed to tackle high-dimensional and computationally heavy problems.The global surrogate model offers a good approximation of the entire problem space,while the local surrogate model focuses on refining the solution near the current best option,improving local optimization.To test the effectiveness of the SA-FMO algorithm,we first conduct experiments using six benchmark functions in a 50-dimensional space.We then apply the algorithm to optimize urban rail transit routes,focusing on the Train Routing Optimization problem.This aims to improve operational efficiency and vehicle turnover in situations with uneven passenger flow during transit disruptions.The results show that SA-FMO can effectively improve optimization outcomes in complex transportation scenarios.展开更多
Ecological barriers present significant challenges to bird migration by limiting the availability of stopover sites and shelters. The Qinghai-Tibet Plateau, a major migratory barrier located in higher latitude Central...Ecological barriers present significant challenges to bird migration by limiting the availability of stopover sites and shelters. The Qinghai-Tibet Plateau, a major migratory barrier located in higher latitude Central Asia, exerts a substantial influence on avian migration patterns. Species traversing such ecological barriers may adopt multiple optimal routes, which can contribute to the formation of migratory divides. From 2018 to 2021, the migration routes of 13 adult Common Cuckoos (Cuculus canorus) breeding in the north of the Qinghai-Tibet Plateau were tracked using satellite transmitters. We found Common Cuckoos have two primary migration routes: western and eastern, respectively following western and eastern edges of the Qinghai-Tibet plateau. The eastern and western routes are likely the optimal routes for the Central Asian Common Cuckoos population to navigate the Qinghai-Tibet Plateau. Furthermore, two individuals exhibited intermediate migration routes, suggesting attempted traverses of the Qinghai-Tibet Plateau, although neither completed the migration. These intermediate routes may indicate migratory behavior influenced by hybridization between eastern and western populations or migratory flexibility. Common Cuckoos exhibit significantly faster migration speed, flight speed, and shorter stopover durations during spring compared to autumn. The observed seasonal differences in migration behavior support birds following time-minimization strategies during spring migration. These results revealed the diverse migration routes of Common Cuckoos shaped by the Qinghai-Tibet Plateau and seasonal variation in migration patterns.展开更多
Global warming has made the regular operation of Arctic routes possible.This study selects hub ports based on infrastructure conditions and sea ice status,and then designs two pendulum route solutions for the Northeas...Global warming has made the regular operation of Arctic routes possible.This study selects hub ports based on infrastructure conditions and sea ice status,and then designs two pendulum route solutions for the Northeast Passage according to the distance between hub ports and ice-covered areas.We employ an evaluation framework combining annual profit metrics with discounted net present value(NPV)analysis,conducting probabilistic economic assessments through Monte Carlo simulations(20,000 iterations).Key findings indicate that(1)both solutions demonstrate>90%probability of economic viability and(2)Solution I′,with hub ports closer to ice-covered areas than those in Solution II,yields 5.02%higher mean annual profit and 4.69%greater NPV.The results indicate that pendulum routes in the Northeast Passage can achieve economic benefits by enabling year-round regular operations.Moreover,shorter shipping distances between hub ports and ice-covered areas enhance economic viability.展开更多
The rapid transformation of Arctic maritime routes,driven by diminishing sea ice and shifting geopolitical conditions,presents both opportunities and challenges for global shipping.This study develops an integrated op...The rapid transformation of Arctic maritime routes,driven by diminishing sea ice and shifting geopolitical conditions,presents both opportunities and challenges for global shipping.This study develops an integrated optimization framework for sustainable Arctic marine logistics,grounded in Agile Supply Chain Theory(ASCT),to address cost efficiency,environmental sustainability,and operational robustness under climate and policy uncertainty.A Mixed‐Integer Linear Programming(MILP)model was employed to optimize vessel routing across Arctic corridors,incorporating Energy Efficiency Operational Indicator(EEOI)and Carbon Intensity Indicator(CII)metrics directly into the objective function.Scenario analyses tested performance under varying climate conditions and policy constraints.The model was parameterized using vessel operational data from Arctic shipping logs,environmental datasets from ESA CryoSat‐2 and NSIDC,port accessibility records from Arctic port authorities,and economic data from Clarksons and the World Bank,ensuring realistic and replicable inputs for the analysis.Results demonstrate that ASCT‐based optimized routes achieved an average 14.8%reduction in operating costs,12.3%reduction in CO₂emissions,and an 11.6%improvement in EEOI,with the majority of voyages improving by at least one CII grade.Robustness analysis showed that optimized routes maintained up to 14.7 percentage points higher feasibility under severe ice scenarios and reduced cost volatility by 20–28%under carbon tax regimes.These findings confirm the value of embedding agility and resilience principles into Arctic shipping,aligning operational efficiency with International Maritime Organization(IMO)decarbonization objectives.The study extends ASCT into extreme maritime contexts,offering a replicable model for sustainable route planning in high‐risk logistics sectors.展开更多
Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combinin...Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks.展开更多
To improve the efficiency of ship traffic in frequently traded sea areas and respond to the national“dual-carbon”strategy,a multi-objective ship route induction model is proposed.Considering the energy-saving and en...To improve the efficiency of ship traffic in frequently traded sea areas and respond to the national“dual-carbon”strategy,a multi-objective ship route induction model is proposed.Considering the energy-saving and environmental issues of ships,this study aims to improve the transportation efficiency of ships by providing a ship route induction method.Ship data from a certain bay during a defined period are collected,and an improved backpropagation neural network algorithm is used to forecast ship traffic.On the basis of the forecasted data and ship route induction objectives,dynamic programming of ship routes is performed.Experimental results show that the routes planned using this induction method reduce the combined cost by 17.55%compared with statically induced routes.This method has promising engineering applications in improving ship navigation efficiency,promoting energy conservation,and reducing emissions.展开更多
The Routing Protocol for Low-power and Lossy Networks(RPL)is widely used in Internet of Things(IoT)systems,where devices usually have very limited resources.However,RPL still faces several problems,such as high energy...The Routing Protocol for Low-power and Lossy Networks(RPL)is widely used in Internet of Things(IoT)systems,where devices usually have very limited resources.However,RPL still faces several problems,such as high energy usage,unstable links,and inefficient routing decisions,which reduce the overall network performance and lifetime.In this work,we introduce TABURPL,an improved routing method that applies Tabu Search(TS)to optimize the parent selection process.The method uses a combined cost function that considers Residual Energy,Transmission Energy,Distance to the Sink,Hop Count,Expected Transmission Count(ETX),and Link Stability Rate(LSR).Simulation results show that TABURPL improves link stability,lowers energy consumption,and increases the packet delivery ratio compared with standard RPL and other existing approaches.These results indicate that Tabu Search can handle the complex trade-offs in IoT routing and can provide a more reliable solution for extending the network lifetime.展开更多
With the increasing complexity of logistics operations,traditional static vehicle routing models are no longer sufficient.In practice,customer demands often arise dynamically,and multi-depot systems are commonly used ...With the increasing complexity of logistics operations,traditional static vehicle routing models are no longer sufficient.In practice,customer demands often arise dynamically,and multi-depot systems are commonly used to improve efficiency.This paper first introduces a vehicle routing problem with the goal of minimizing operating costs in a multi-depot environment with dynamic demand.New customers appear in the delivery process at any time and are periodically optimized according to time slices.Then,we propose a scheduling system TS-DPU based on an improved ant colony algorithm TS-ACO to solve this problem.The classical ant colony algorithm uses spatial distance to select nodes,while TS-ACO considers the impact of both temporal and spatial distance on node selection.Meanwhile,we adopt Cordeau’s Multi-Depot Vehicle Routing Problem with Time Windows(MDVRPTW)dataset to evaluate the performance of our system.According to the experimental results,TS-ACO,which considers spatial and temporal distance,is more effective than the classical ACO,which only considers spatial distance.展开更多
Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of...Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of user preferences.To address this,we propose a Conditional Generative Adversarial Network(CGAN)that generates diverse and highly relevant itineraries.Our approach begins by constructing a conditional vector that encapsulates a user’s profile.This vector uniquely fuses embeddings from a Heterogeneous Information Network(HIN)to model complex user-place-route relationships,a Recurrent Neural Network(RNN)to capture sequential path dynamics,and Neural Collaborative Filtering(NCF)to incorporate collaborative signals from the wider user base.This comprehensive condition,further enhanced with features representing user interaction confidence and uncertainty,steers a CGAN stabilized by spectral normalization to generate high-fidelity latent route representations,effectively mitigating the data sparsity problem.Recommendations are then formulated using an Anchor-and-Expand algorithm,which selects relevant starting Points of Interest(POI)based on user history,then expands routes through latent similarity matching and geographic coherence optimization,culminating in Traveling Salesman Problem(TSP)-based route optimization for practical travel distances.Experiments on a real-world check-in dataset validate our model’s unique generative capability,achieving F1 scores ranging from 0.163 to 0.305,and near-zero pairs−F1 scores between 0.002 and 0.022.These results confirm the model’s success in generating novel travel routes by recommending new locations and sequences rather than replicating users’past itineraries.This work provides a robust solution for personalized travel planning,capable of generating novel and compelling routes for both new and existing users by learning from collective travel intelligence.展开更多
Wireless Sensor Networks(WSNs)have become foundational in numerous real-world applications,ranging from environmental monitoring and industrial automation to healthcare systems and smart city development.As these netw...Wireless Sensor Networks(WSNs)have become foundational in numerous real-world applications,ranging from environmental monitoring and industrial automation to healthcare systems and smart city development.As these networks continue to grow in scale and complexity,the need for energy-efficient,scalable,and robust communication protocols becomes more critical than ever.Metaheuristic algorithms have shown significant promise in addressing these challenges,offering flexible and effective solutions for optimizing WSN performance.Among them,the Grey Wolf Optimizer(GWO)algorithm has attracted growing attention due to its simplicity,fast convergence,and strong global search capabilities.Accordingly,this survey provides an in-depth review of the applications of GWO and its variants for clustering,multi-hop routing,and hybrid cluster-based routing in WSNs.We categorize and analyze the existing GWO-based approaches across these key network optimization tasks,discussing the different problem formulations,decision variables,objective functions,and performance metrics used.In doing so,we examine standard GWO,multi-objective GWO,and hybrid GWO models that incorporate other computational intelligence techniques.Each method is evaluated based on how effectively it addresses the core constraints of WSNs,including energy consumption,communication overhead,and network lifetime.Finally,this survey outlines existing gaps in the literature and proposes potential future research directions aimed at enhancing the effectiveness and real-world applicability of GWO-based techniques for WSN clustering and routing.Our goal is to provide researchers and practitioners with a clear,structured understanding of the current state of GWO in WSNs and inspire further innovation in this evolving field.展开更多
Mega low Earth orbit(LEO)satellite networks serve as effective complements to terrestrial networks.However,the dual mobility of users and LEO satellites makes inter-satellite handovers more frequent for users.Moreover...Mega low Earth orbit(LEO)satellite networks serve as effective complements to terrestrial networks.However,the dual mobility of users and LEO satellites makes inter-satellite handovers more frequent for users.Moreover,there are both ascending and descending segments in widely deployed walker-delta constellations.Even if the locations of users do not change,when the access satellites of the communicating parties are not in the same ascending or descending segment,the end-to-end latency between them will increase.To address this challenge,the self-decision handover(SDH)strategy and the joint decision handover(JDH)strategy are proposed,and they both incorporate the routing hops as a crucial handover criterion to minimize the end-to-end latency.In addition,the shortest route hop-count algorithm is designed to assist in the handover decision-making process.Simulations demonstrate that the proposed handover strategies outperform the traditional handover strategies in terms of the number of handovers and end-to-end latency.展开更多
The fusion of urban agriculture, ecotourism and cultural innovation industry has been a necessary way for industry updating, value increase and income im- provement of farmers in suburbs. The methods available of the ...The fusion of urban agriculture, ecotourism and cultural innovation industry has been a necessary way for industry updating, value increase and income im- provement of farmers in suburbs. The methods available of the fusion are as fol- lows： corporation development and operation, led by government with an integrated plan; corporation management and development under guidance of market with sup- port from government; collective development under guidance of market and policies; individual development and operation with the model of ＂villagers participation de- pending on infrastructure provided by government＂. The four routes enjoy exclusive advantages and characters. Hence, different villages and towns should adopt the most suitable one according to local conditions for further development and management.展开更多
In spite of advances in surgical care and rehabilitation, the consequences of spinal cord injury （SCI） are still challenging. Several experimental therapeutic strategies have been studied in the SCI field, and recen...In spite of advances in surgical care and rehabilitation, the consequences of spinal cord injury （SCI） are still challenging. Several experimental therapeutic strategies have been studied in the SCI field, and recent advances have led to the development of therapies that may act on the inhibitory microenvironment. Assorted lineages of stem cells are considered a good treatment for SCI. This study investigated the effect of systemic transplantation of mesenchymal stem cells （MSCs） in a compressive SCI model. Here we present results of the intraperitoneal route, which has not been used previously for MSC administration after compressive SCI. We used adult female C57BL/6 mice that underwent laminectomy at the T9 level, followed by spinal cord compression for 1 minute with a 30-g vascular clip. The animals were divided into five groups： sham （anesthesia and laminectomy but without compression injury induction）, MSC i.p. （intraperitoneal injection of 8×10^5 MSCs in 500 μL of DMEM at 7 days after SCI）, MSC i.v. （intravenous injection of 8 × 10^5 MSCs in 500μL of DMEM at 7 days after SCI）, DMEM i.p. （intraperitoneal injection of 500μL of DMEM at 7 days after SCI）, DMEM i.v. （intravenous injection of 500 μL of DMEM at 7 days after SCI）. The effects of MSCs transplantation in white matter sparing were analyzed by luxol fast blue staining. The number of preserved fibers was counted in semithin sections stained with toluidine blue and the presence of trophic factors was analyzed by immunohistochemistry. In addition, we analyzed the locomotor performance with Basso Mouse Scale and Global Mobility Test. Our results showed white matter preservation and a larger number of preserved fibers in the MSC groups than in the DMEM groups. Furthermore, the MSC groups had higher levels of trophic factors （brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3 and neurotrophin-4） in the spinal cord and improved locomotor performance. Our results indicate that injection of MSCs by either intraperitoneal or intravenous routes results in beneficial outcomes and can be elected as a choice for SCI treatment.展开更多
The rapid increase in energy demand,the extensive use of fossil fuels and the urgent need to reduce the carbon dioxide emissions have raised concerns in the transportation sector.Alternate renewable and sustainable so...The rapid increase in energy demand,the extensive use of fossil fuels and the urgent need to reduce the carbon dioxide emissions have raised concerns in the transportation sector.Alternate renewable and sustainable sources have become the ultimate solution to overcome the expected depletion of fossil fuels.The conversion of lignocellulosic biomass to liquid(BtL)transportation fuels seems to be a promising path and presents advantages over first generation biofuels and fossil fuels.Therefore,development of BtL systems is critical to increase the potential of this resource in a sustainable and economic way.Conversion of lignocellulosic BtL transportation fuels,such as,gasoline,diesel and jet fuel can be accomplished through various thermochemical processes and processing routes.The major steps for the production of BtL fuels involve feedstock selection,physical pretreatment,production of bio-oil,upgrading of bio-oil to transportation fuels and recovery of value-added products.The present work is aiming to give a comprehensive review of the current process technologies following these major steps and the current scenarios of biomass to liquid facilities for the production of biofuels.展开更多
With rapid development of air transportation,the airspace structure of the future will need to be flexible and dynamic to accommodate the increase in traffic demand.The corridors-in-the-sky has become a new technology...With rapid development of air transportation,the airspace structure of the future will need to be flexible and dynamic to accommodate the increase in traffic demand.The corridors-in-the-sky has become a new technology to support the full exploitation and utilization of airspace resources.This paper proposes a method of designing corridor,identifying congestion state,and analyzing the influence of air routes’traffic flow.From this,we have reached a number of conclusions.(1)The congestion periods present the multi-peak"wavy"scattered distributions and the peaks back-end agglomeration characteristics in the whole day.(2)The congestion segments present the structural characteristics of unbalanced coverage and concentrated distribution to the crossing points.The corridors with high congestion level present as an italic"N-shaped"frame,which presents incomplete penetration of short segments.(3)For the temporal and spatial interaction,there are two types of congestion segments,and there are some common congestion periods in different congestion segments of multiple corridors.The high-density air route plays a relatively decisive role in corridor congestion,and the influence of two directions is unbalanced.This research can provide a basis for the dynamic evaluation of China’s airspace resources and corridors construction in the future.展开更多
This paper presents a new passive-biped model consisting of a simplest walking model beneath an upper body, with no kinematic constraint. The upper body is attached to the legs with a linear torsional spring. The mode...This paper presents a new passive-biped model consisting of a simplest walking model beneath an upper body, with no kinematic constraint. The upper body is attached to the legs with a linear torsional spring. The model is a passive dynamic walker, so it walks down a slope without energy input. The governing equations of motion are derived and simulated for the parameter analysis purposes. Simulation results reveal some different routes to chaos that have not been observed in previous models.展开更多
AIM:To compare postoperative complications and prognosis of esophageal squamous cell carcinoma patients treated with different routes of reconstruction. METHODS:After obtaining approval from the Medical Ethics Committ...AIM:To compare postoperative complications and prognosis of esophageal squamous cell carcinoma patients treated with different routes of reconstruction. METHODS:After obtaining approval from the Medical Ethics Committee of the Sun Yat-Sen University Cancer Center, we retrospectively reviewed data from 306 consecutive patients with histologically diagnosed esophageal squamous cell carcinoma who were treated between 2001 and 2011. All patients underwent radical McKeown-type esophagectomy with at least two-field lymphadenectomy. Regular follow-up was performed in our outpatient department. Postoperative complica-tions and long-term survival were analyzed by treatment modality, baseline patient characteristics, and operative procedure. Data from patients treated via the retrosternal and posterior mediastinal routes were compared. RESULTS:The posterior mediastinal and retrosternal reconstruction routes were employed in 120 and 186 patients, respectively. Pulmonary complications were the most common complications experienced during the postoperative period (46.1% of all patients; 141/306). Compared to the retrosternal route, the posterior mediastinal reconstruction route was associated with a lower incidence of anastomotic stricture (15.8% vs 27.4%, P = 0.018) and less surgical bleeding (242.8 ± 114.2 mL vs 308.2 ± 168.4 mL, P < 0.001). The median survival time was 26.8 mo (range:1.6-116.1 mo). Upon uni/multivariate analysis, a lower preoperative albumin level (P = 0.009) and a more advanced pathological stage (pT; P = 0.006; pN; P < 0.001) were identified as independent factors predicting poor prognosis. The reconstruction route did not influence prognosis (P = 0.477). CONCLUSION:The posterior mediastinal route of reconstruction reduces incidence of postoperative complications but does not affect survival. This route is recommended for resectable esophageal squamous cell carcinoma.展开更多
Al-Cu alloy was deformed through equal channel angular pressing(ECAP) by routes A,Ba,Bc and C up to 5 passes.ECAP was done using a 90° die for three different conditions,namely 1) as received,2) solutionised at 7...Al-Cu alloy was deformed through equal channel angular pressing(ECAP) by routes A,Ba,Bc and C up to 5 passes.ECAP was done using a 90° die for three different conditions,namely 1) as received,2) solutionised at 768 K for 1 h and 3) solutionised at 768 K for 1 h + aged at 468 K for 5 h.The microstructure,microhardness and tensile strength were studied for all the three conditions and four routes.Significant improvement in hardness(HV 184 after five passes) and strength(602 MPa after three passes) was observed in solutionised and aged 2014 Al alloy deformed through route Bc.Microstructure evolution was reasonably equiaxed in route Bc with aspect ratio of 1.6.Solutionised and aged 2014 Al alloy deformed through route Bc was identified to have better microstructure and mechanical property than the other processing routes and conditions.展开更多
基金financially supported by the National Key Research and Development Program of China(No.2023YFD1800403 and 2023YFD1800404)。
文摘Monkeypox virus(MPXV),a member of the Orthopoxvirus genus,caused a large-scale global outbreak in 2022.Developing mouse models for MPXV infection is crucial for advancing research on vaccines and therapeutic interventions.To address this,we conducted a comparative study on the susceptibility of six mouse strains—severe combined immune-deficiency(SCID),nude,genetically diabetic(db/db)and obese(ob/ob),C57BL/6J,and BALB/c—to MPXV infection.Mouse strains were infected with MPXV via intranasal inoculation,and body weight changes and mortality were monitored post-infection.Additionally,the tissue distribution of MPXV and the pathological changes in the lung tissues of the infected mice were evaluated.The results demonstrated that SCID and nude mice exhibited significant weight loss following MPXV infection,with 100%mortality observed in SCID mice,while no mortality occurred in nude mice.In contrast,the other mouse strains showed no significant weight loss or mortality.Notably,the viral load in the lung tissues of SCID and nude mice was the highest among the tested strains.Furthermore,we investigated the impact of different inoculation routes—intranasal(I.N.),intraperitoneal(I.P.),and intravenous(I.V.)—on the pathogenicity of MPXV in mice.The results revealed that the intravenous route induced more pronounced pathogenic effects compared to the intranasal and intraperitoneal routes.In summary,this study provides valuable insights into the development of MPXV-infected mouse models,offering a foundation for further research on MPXV pathogenesis and therapeutic drug development.
基金Project(2023GK2020)supported by the Key Research and Development Program of Hunan Province,China。
文摘Microstructure and mechanical properties of aged Mg-10Gd-2Y-0.4Zr-0.4Ag alloy sheets prepared by different rolling routes were investigated.The results showed that the cross rolling aged(CRA)sheet possesses larger grain size than unidirectional rolling aged(URA)sheet due to the occurrence of dynamic recovery during rolling which reduces the dislocation density and delays dynamic recrystallization(DRX).The URA sheet has basal texture and RD favored texture while CRA sheet has multiple-peak texture.Both sheets precipitate β'phase and CRA sheet exhibits a stronger aging response.The CRA sheet has higher yield strength and tensile strength than URA sheet,with reduced yield strength anisotropy but increased tensile strength anisotropy.Taking into account different strengthening mechanisms,although the finer grain size of URA sheet enhances grain boundary strengthening,CRA sheet is more responsive to aging,leading to superior aging-precipitated phase strengthening and consequently higher yield strength.
基金supported by the National Natural Science Foundation of China(Project No.52172321,52102391)Sichuan Province Science and Technology Innovation Talent Project(2024JDRC0020)+1 种基金China Shenhua Energy Company Limited Technology Project(GJNY-22-7/2300-K1220053)Key science and technology projects in the transportation industry of the Ministry of Transport(2022-ZD7-132).
文摘Meta-heuristic evolutionary algorithms have become widely used for solving complex optimization problems.However,their effectiveness in real-world applications is often limited by the need for many evaluations,which can be both costly and time-consuming.This is especially true for large-scale transportation networks,where the size of the problem and the high computational cost can hinder the algorithm’s performance.To address these challenges,recent research has focused on using surrogate-assisted models.These models aim to reduce the number of expensive evaluations and improve the efficiency of solving time-consuming optimization problems.This paper presents a new two-layer Surrogate-Assisted Fish Migration Optimization(SA-FMO)algorithm designed to tackle high-dimensional and computationally heavy problems.The global surrogate model offers a good approximation of the entire problem space,while the local surrogate model focuses on refining the solution near the current best option,improving local optimization.To test the effectiveness of the SA-FMO algorithm,we first conduct experiments using six benchmark functions in a 50-dimensional space.We then apply the algorithm to optimize urban rail transit routes,focusing on the Train Routing Optimization problem.This aims to improve operational efficiency and vehicle turnover in situations with uneven passenger flow during transit disruptions.The results show that SA-FMO can effectively improve optimization outcomes in complex transportation scenarios.
基金supported by the National Natural Science Foundation of China(Grant No.31672296).
文摘Ecological barriers present significant challenges to bird migration by limiting the availability of stopover sites and shelters. The Qinghai-Tibet Plateau, a major migratory barrier located in higher latitude Central Asia, exerts a substantial influence on avian migration patterns. Species traversing such ecological barriers may adopt multiple optimal routes, which can contribute to the formation of migratory divides. From 2018 to 2021, the migration routes of 13 adult Common Cuckoos (Cuculus canorus) breeding in the north of the Qinghai-Tibet Plateau were tracked using satellite transmitters. We found Common Cuckoos have two primary migration routes: western and eastern, respectively following western and eastern edges of the Qinghai-Tibet plateau. The eastern and western routes are likely the optimal routes for the Central Asian Common Cuckoos population to navigate the Qinghai-Tibet Plateau. Furthermore, two individuals exhibited intermediate migration routes, suggesting attempted traverses of the Qinghai-Tibet Plateau, although neither completed the migration. These intermediate routes may indicate migratory behavior influenced by hybridization between eastern and western populations or migratory flexibility. Common Cuckoos exhibit significantly faster migration speed, flight speed, and shorter stopover durations during spring compared to autumn. The observed seasonal differences in migration behavior support birds following time-minimization strategies during spring migration. These results revealed the diverse migration routes of Common Cuckoos shaped by the Qinghai-Tibet Plateau and seasonal variation in migration patterns.
文摘Global warming has made the regular operation of Arctic routes possible.This study selects hub ports based on infrastructure conditions and sea ice status,and then designs two pendulum route solutions for the Northeast Passage according to the distance between hub ports and ice-covered areas.We employ an evaluation framework combining annual profit metrics with discounted net present value(NPV)analysis,conducting probabilistic economic assessments through Monte Carlo simulations(20,000 iterations).Key findings indicate that(1)both solutions demonstrate>90%probability of economic viability and(2)Solution I′,with hub ports closer to ice-covered areas than those in Solution II,yields 5.02%higher mean annual profit and 4.69%greater NPV.The results indicate that pendulum routes in the Northeast Passage can achieve economic benefits by enabling year-round regular operations.Moreover,shorter shipping distances between hub ports and ice-covered areas enhance economic viability.
文摘The rapid transformation of Arctic maritime routes,driven by diminishing sea ice and shifting geopolitical conditions,presents both opportunities and challenges for global shipping.This study develops an integrated optimization framework for sustainable Arctic marine logistics,grounded in Agile Supply Chain Theory(ASCT),to address cost efficiency,environmental sustainability,and operational robustness under climate and policy uncertainty.A Mixed‐Integer Linear Programming(MILP)model was employed to optimize vessel routing across Arctic corridors,incorporating Energy Efficiency Operational Indicator(EEOI)and Carbon Intensity Indicator(CII)metrics directly into the objective function.Scenario analyses tested performance under varying climate conditions and policy constraints.The model was parameterized using vessel operational data from Arctic shipping logs,environmental datasets from ESA CryoSat‐2 and NSIDC,port accessibility records from Arctic port authorities,and economic data from Clarksons and the World Bank,ensuring realistic and replicable inputs for the analysis.Results demonstrate that ASCT‐based optimized routes achieved an average 14.8%reduction in operating costs,12.3%reduction in CO₂emissions,and an 11.6%improvement in EEOI,with the majority of voyages improving by at least one CII grade.Robustness analysis showed that optimized routes maintained up to 14.7 percentage points higher feasibility under severe ice scenarios and reduced cost volatility by 20–28%under carbon tax regimes.These findings confirm the value of embedding agility and resilience principles into Arctic shipping,aligning operational efficiency with International Maritime Organization(IMO)decarbonization objectives.The study extends ASCT into extreme maritime contexts,offering a replicable model for sustainable route planning in high‐risk logistics sectors.
文摘Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks.
基金Supported by the National Key R&D Program of China project (2017YFC0805309)the National Natural Science Foundation of China (60602020)。
文摘To improve the efficiency of ship traffic in frequently traded sea areas and respond to the national“dual-carbon”strategy,a multi-objective ship route induction model is proposed.Considering the energy-saving and environmental issues of ships,this study aims to improve the transportation efficiency of ships by providing a ship route induction method.Ship data from a certain bay during a defined period are collected,and an improved backpropagation neural network algorithm is used to forecast ship traffic.On the basis of the forecasted data and ship route induction objectives,dynamic programming of ship routes is performed.Experimental results show that the routes planned using this induction method reduce the combined cost by 17.55%compared with statically induced routes.This method has promising engineering applications in improving ship navigation efficiency,promoting energy conservation,and reducing emissions.
文摘The Routing Protocol for Low-power and Lossy Networks(RPL)is widely used in Internet of Things(IoT)systems,where devices usually have very limited resources.However,RPL still faces several problems,such as high energy usage,unstable links,and inefficient routing decisions,which reduce the overall network performance and lifetime.In this work,we introduce TABURPL,an improved routing method that applies Tabu Search(TS)to optimize the parent selection process.The method uses a combined cost function that considers Residual Energy,Transmission Energy,Distance to the Sink,Hop Count,Expected Transmission Count(ETX),and Link Stability Rate(LSR).Simulation results show that TABURPL improves link stability,lowers energy consumption,and increases the packet delivery ratio compared with standard RPL and other existing approaches.These results indicate that Tabu Search can handle the complex trade-offs in IoT routing and can provide a more reliable solution for extending the network lifetime.
基金supported by the Startup Foundation for Introducing Talent of Nanjing University of Information Science and Technology.
文摘With the increasing complexity of logistics operations,traditional static vehicle routing models are no longer sufficient.In practice,customer demands often arise dynamically,and multi-depot systems are commonly used to improve efficiency.This paper first introduces a vehicle routing problem with the goal of minimizing operating costs in a multi-depot environment with dynamic demand.New customers appear in the delivery process at any time and are periodically optimized according to time slices.Then,we propose a scheduling system TS-DPU based on an improved ant colony algorithm TS-ACO to solve this problem.The classical ant colony algorithm uses spatial distance to select nodes,while TS-ACO considers the impact of both temporal and spatial distance on node selection.Meanwhile,we adopt Cordeau’s Multi-Depot Vehicle Routing Problem with Time Windows(MDVRPTW)dataset to evaluate the performance of our system.According to the experimental results,TS-ACO,which considers spatial and temporal distance,is more effective than the classical ACO,which only considers spatial distance.
基金supported by the Chung-Ang University Research Grants in 2023.Alsothe work is supported by the ELLIIT Excellence Center at Linköping–Lund in Information Technology in Sweden.
文摘Recommending personalized travel routes from sparse,implicit feedback poses a significant challenge,as conventional systems often struggle with information overload and fail to capture the complex,sequential nature of user preferences.To address this,we propose a Conditional Generative Adversarial Network(CGAN)that generates diverse and highly relevant itineraries.Our approach begins by constructing a conditional vector that encapsulates a user’s profile.This vector uniquely fuses embeddings from a Heterogeneous Information Network(HIN)to model complex user-place-route relationships,a Recurrent Neural Network(RNN)to capture sequential path dynamics,and Neural Collaborative Filtering(NCF)to incorporate collaborative signals from the wider user base.This comprehensive condition,further enhanced with features representing user interaction confidence and uncertainty,steers a CGAN stabilized by spectral normalization to generate high-fidelity latent route representations,effectively mitigating the data sparsity problem.Recommendations are then formulated using an Anchor-and-Expand algorithm,which selects relevant starting Points of Interest(POI)based on user history,then expands routes through latent similarity matching and geographic coherence optimization,culminating in Traveling Salesman Problem(TSP)-based route optimization for practical travel distances.Experiments on a real-world check-in dataset validate our model’s unique generative capability,achieving F1 scores ranging from 0.163 to 0.305,and near-zero pairs−F1 scores between 0.002 and 0.022.These results confirm the model’s success in generating novel travel routes by recommending new locations and sequences rather than replicating users’past itineraries.This work provides a robust solution for personalized travel planning,capable of generating novel and compelling routes for both new and existing users by learning from collective travel intelligence.
文摘Wireless Sensor Networks(WSNs)have become foundational in numerous real-world applications,ranging from environmental monitoring and industrial automation to healthcare systems and smart city development.As these networks continue to grow in scale and complexity,the need for energy-efficient,scalable,and robust communication protocols becomes more critical than ever.Metaheuristic algorithms have shown significant promise in addressing these challenges,offering flexible and effective solutions for optimizing WSN performance.Among them,the Grey Wolf Optimizer(GWO)algorithm has attracted growing attention due to its simplicity,fast convergence,and strong global search capabilities.Accordingly,this survey provides an in-depth review of the applications of GWO and its variants for clustering,multi-hop routing,and hybrid cluster-based routing in WSNs.We categorize and analyze the existing GWO-based approaches across these key network optimization tasks,discussing the different problem formulations,decision variables,objective functions,and performance metrics used.In doing so,we examine standard GWO,multi-objective GWO,and hybrid GWO models that incorporate other computational intelligence techniques.Each method is evaluated based on how effectively it addresses the core constraints of WSNs,including energy consumption,communication overhead,and network lifetime.Finally,this survey outlines existing gaps in the literature and proposes potential future research directions aimed at enhancing the effectiveness and real-world applicability of GWO-based techniques for WSN clustering and routing.Our goal is to provide researchers and practitioners with a clear,structured understanding of the current state of GWO in WSNs and inspire further innovation in this evolving field.
基金supported by the State Key Laboratory of Micro-Spacecraft Rapid Design and Intelligent Cluster(MS01240103)the National Natural Science Foundation of China(62071146,62431009)+2 种基金the National 2011 Collaborative Innovation Center of Wireless Communication Technologies(2242022k60006)the Research Project Fund of Songjiang Laboratory(SL20230104)Heilongjiang Province Postdoctoral General Foundation(LBH-Z22133)。
文摘Mega low Earth orbit(LEO)satellite networks serve as effective complements to terrestrial networks.However,the dual mobility of users and LEO satellites makes inter-satellite handovers more frequent for users.Moreover,there are both ascending and descending segments in widely deployed walker-delta constellations.Even if the locations of users do not change,when the access satellites of the communicating parties are not in the same ascending or descending segment,the end-to-end latency between them will increase.To address this challenge,the self-decision handover(SDH)strategy and the joint decision handover(JDH)strategy are proposed,and they both incorporate the routing hops as a crucial handover criterion to minimize the end-to-end latency.In addition,the shortest route hop-count algorithm is designed to assist in the handover decision-making process.Simulations demonstrate that the proposed handover strategies outperform the traditional handover strategies in terms of the number of handovers and end-to-end latency.
基金Supported by Beijing Natural Science Foundation(9122010)~~
文摘The fusion of urban agriculture, ecotourism and cultural innovation industry has been a necessary way for industry updating, value increase and income im- provement of farmers in suburbs. The methods available of the fusion are as fol- lows： corporation development and operation, led by government with an integrated plan; corporation management and development under guidance of market with sup- port from government; collective development under guidance of market and policies; individual development and operation with the model of ＂villagers participation de- pending on infrastructure provided by government＂. The four routes enjoy exclusive advantages and characters. Hence, different villages and towns should adopt the most suitable one according to local conditions for further development and management.
文摘In spite of advances in surgical care and rehabilitation, the consequences of spinal cord injury （SCI） are still challenging. Several experimental therapeutic strategies have been studied in the SCI field, and recent advances have led to the development of therapies that may act on the inhibitory microenvironment. Assorted lineages of stem cells are considered a good treatment for SCI. This study investigated the effect of systemic transplantation of mesenchymal stem cells （MSCs） in a compressive SCI model. Here we present results of the intraperitoneal route, which has not been used previously for MSC administration after compressive SCI. We used adult female C57BL/6 mice that underwent laminectomy at the T9 level, followed by spinal cord compression for 1 minute with a 30-g vascular clip. The animals were divided into five groups： sham （anesthesia and laminectomy but without compression injury induction）, MSC i.p. （intraperitoneal injection of 8×10^5 MSCs in 500 μL of DMEM at 7 days after SCI）, MSC i.v. （intravenous injection of 8 × 10^5 MSCs in 500μL of DMEM at 7 days after SCI）, DMEM i.p. （intraperitoneal injection of 500μL of DMEM at 7 days after SCI）, DMEM i.v. （intravenous injection of 500 μL of DMEM at 7 days after SCI）. The effects of MSCs transplantation in white matter sparing were analyzed by luxol fast blue staining. The number of preserved fibers was counted in semithin sections stained with toluidine blue and the presence of trophic factors was analyzed by immunohistochemistry. In addition, we analyzed the locomotor performance with Basso Mouse Scale and Global Mobility Test. Our results showed white matter preservation and a larger number of preserved fibers in the MSC groups than in the DMEM groups. Furthermore, the MSC groups had higher levels of trophic factors （brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3 and neurotrophin-4） in the spinal cord and improved locomotor performance. Our results indicate that injection of MSCs by either intraperitoneal or intravenous routes results in beneficial outcomes and can be elected as a choice for SCI treatment.
基金financial support from CONACYT-The Mexican National Council for Science and Technology (REFERENCE: 326204/439098)the University of Southern Denmark
文摘The rapid increase in energy demand,the extensive use of fossil fuels and the urgent need to reduce the carbon dioxide emissions have raised concerns in the transportation sector.Alternate renewable and sustainable sources have become the ultimate solution to overcome the expected depletion of fossil fuels.The conversion of lignocellulosic biomass to liquid(BtL)transportation fuels seems to be a promising path and presents advantages over first generation biofuels and fossil fuels.Therefore,development of BtL systems is critical to increase the potential of this resource in a sustainable and economic way.Conversion of lignocellulosic BtL transportation fuels,such as,gasoline,diesel and jet fuel can be accomplished through various thermochemical processes and processing routes.The major steps for the production of BtL fuels involve feedstock selection,physical pretreatment,production of bio-oil,upgrading of bio-oil to transportation fuels and recovery of value-added products.The present work is aiming to give a comprehensive review of the current process technologies following these major steps and the current scenarios of biomass to liquid facilities for the production of biofuels.
基金National Natural Science Foundation of China,No.41671121
文摘With rapid development of air transportation,the airspace structure of the future will need to be flexible and dynamic to accommodate the increase in traffic demand.The corridors-in-the-sky has become a new technology to support the full exploitation and utilization of airspace resources.This paper proposes a method of designing corridor,identifying congestion state,and analyzing the influence of air routes’traffic flow.From this,we have reached a number of conclusions.(1)The congestion periods present the multi-peak"wavy"scattered distributions and the peaks back-end agglomeration characteristics in the whole day.(2)The congestion segments present the structural characteristics of unbalanced coverage and concentrated distribution to the crossing points.The corridors with high congestion level present as an italic"N-shaped"frame,which presents incomplete penetration of short segments.(3)For the temporal and spatial interaction,there are two types of congestion segments,and there are some common congestion periods in different congestion segments of multiple corridors.The high-density air route plays a relatively decisive role in corridor congestion,and the influence of two directions is unbalanced.This research can provide a basis for the dynamic evaluation of China’s airspace resources and corridors construction in the future.
文摘This paper presents a new passive-biped model consisting of a simplest walking model beneath an upper body, with no kinematic constraint. The upper body is attached to the legs with a linear torsional spring. The model is a passive dynamic walker, so it walks down a slope without energy input. The governing equations of motion are derived and simulated for the parameter analysis purposes. Simulation results reveal some different routes to chaos that have not been observed in previous models.
基金Supported by Science and Technology Project of Guangdong Province, China, No. 2010B031600220 and 2008B030303008
文摘AIM:To compare postoperative complications and prognosis of esophageal squamous cell carcinoma patients treated with different routes of reconstruction. METHODS:After obtaining approval from the Medical Ethics Committee of the Sun Yat-Sen University Cancer Center, we retrospectively reviewed data from 306 consecutive patients with histologically diagnosed esophageal squamous cell carcinoma who were treated between 2001 and 2011. All patients underwent radical McKeown-type esophagectomy with at least two-field lymphadenectomy. Regular follow-up was performed in our outpatient department. Postoperative complica-tions and long-term survival were analyzed by treatment modality, baseline patient characteristics, and operative procedure. Data from patients treated via the retrosternal and posterior mediastinal routes were compared. RESULTS:The posterior mediastinal and retrosternal reconstruction routes were employed in 120 and 186 patients, respectively. Pulmonary complications were the most common complications experienced during the postoperative period (46.1% of all patients; 141/306). Compared to the retrosternal route, the posterior mediastinal reconstruction route was associated with a lower incidence of anastomotic stricture (15.8% vs 27.4%, P = 0.018) and less surgical bleeding (242.8 ± 114.2 mL vs 308.2 ± 168.4 mL, P < 0.001). The median survival time was 26.8 mo (range:1.6-116.1 mo). Upon uni/multivariate analysis, a lower preoperative albumin level (P = 0.009) and a more advanced pathological stage (pT; P = 0.006; pN; P < 0.001) were identified as independent factors predicting poor prognosis. The reconstruction route did not influence prognosis (P = 0.477). CONCLUSION:The posterior mediastinal route of reconstruction reduces incidence of postoperative complications but does not affect survival. This route is recommended for resectable esophageal squamous cell carcinoma.
文摘Al-Cu alloy was deformed through equal channel angular pressing(ECAP) by routes A,Ba,Bc and C up to 5 passes.ECAP was done using a 90° die for three different conditions,namely 1) as received,2) solutionised at 768 K for 1 h and 3) solutionised at 768 K for 1 h + aged at 468 K for 5 h.The microstructure,microhardness and tensile strength were studied for all the three conditions and four routes.Significant improvement in hardness(HV 184 after five passes) and strength(602 MPa after three passes) was observed in solutionised and aged 2014 Al alloy deformed through route Bc.Microstructure evolution was reasonably equiaxed in route Bc with aspect ratio of 1.6.Solutionised and aged 2014 Al alloy deformed through route Bc was identified to have better microstructure and mechanical property than the other processing routes and conditions.
