OBJECTIVE:To take Baihui(GV20)and Fengchi(GB20)targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating acupoints.METHODS:The target informa...OBJECTIVE:To take Baihui(GV20)and Fengchi(GB20)targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating acupoints.METHODS:The target information of Baihui(GV20)and Fengchi(GB20)was retrieved,and after intersection with migraine,Kyoto Encyclopedia of Genes and Genomes(KEGG),Reactome,and Uni Prot Keywords were used for functional enrichment.After selecting the main pathway,rats were selected and nitroglycerin was used for modeling,and the behavioral scores,inflammatory factors,heme oxygenase 1(HMOX1),protein kinase B(AKT1),signal transducer and activator of transcription 3(STAT3),phosphorylated extracellular signal-regulated kinase 1/2(P-ERK1/ERK2)and other states of the rats in the acupuncture,twisting,and electroacupuncture groups were compared.RESULTS:A total of 135 Baihui(GV20)targets and 27 Fengchi(GB20)targets were collected.A total of 73 target information were obtained after the intersection of these targets in migraine.These 73 targets have three main pathways:hypoxia-inducible factor 1(HIF-1)signaling pathway,signaling by interleukins and inflammatory response.The main targets in the pathway were verified and found that interleukin-1 beta(IL-1β),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)and HMOX1,AKT1,STAT3,P-ERK1/ERK2 can be regulated by Baihui(GV20)and Fengchi(GB20).CONCLUSION:Baihui(GV20)and Fengchi(GB20)can regulate migraine by regulating inflammatory factors and HMOX1,AKT1,STAT3,P-ERK1/ERK2 and other changes in HIF-1 signaling pathway,Signaling by Interleukins and Inflammatory response pathways.Based on systems biology and network pharmacology,and with the model of"acupoint-target-disease",explore the research methods of systematic acupuncture and moxibustion.We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.展开更多
Objective： To observe the therapeutic effect of suspended moxibustion at Baihui （GV 20） for insomnia. Methods： 75 cases were divided randomly into two groups, with 40 cases in the treatment group treated by suspen...Objective： To observe the therapeutic effect of suspended moxibustion at Baihui （GV 20） for insomnia. Methods： 75 cases were divided randomly into two groups, with 40 cases in the treatment group treated by suspended moxibustion over Baihui （GV 20） and 35 cases in the control group treated by oral administration of Estazolam. Results： The difference in therapeutic effect between the two groups was not statistically significant （P〉0.1）. Conelusion： It was concluded that suspended moxibustion at Baihui （GV 20） is as effective as Estazolam for insomnia.展开更多
Focusing on the effect specificity of meridian points along the running course of meridian,by taking the treatment of post-stroke depression(PSD)with the acupoints of the governor vessel as an example,the correlation ...Focusing on the effect specificity of meridian points along the running course of meridian,by taking the treatment of post-stroke depression(PSD)with the acupoints of the governor vessel as an example,the correlation between meridian points and disease was explored.The specific regulatory effect of governor vessel,Baihui(百会GV20)and Shenting(神庭GV24)in physiology and pathology in PSD and the material basis of the specificity effect were analyzed.Finally,the specific relationship between the acupoints of the governor vessel and PSD was explained.展开更多
Acupuncture at Baihui（GV 20）was employed in treating 32 cases of functionalenuresis.As a result,the curative rate reached 81.25％,but that in control group of 32 cases withoutneedling Baihui point was 56.25％.There ...Acupuncture at Baihui（GV 20）was employed in treating 32 cases of functionalenuresis.As a result,the curative rate reached 81.25％,but that in control group of 32 cases withoutneedling Baihui point was 56.25％.There was a significant difference in statistics（P【0.05）.It indi- cates that Baihui can enhance the therapeutic effect of acupuncture on treating enuresis.展开更多
Objective:To observe the effects of shallow needling at Baihui(GV20)on neurological function and cerebral hemodynamics in patients with poststroke depression(PSD).Methods:A total of 90 PSD patients were divided into a...Objective:To observe the effects of shallow needling at Baihui(GV20)on neurological function and cerebral hemodynamics in patients with poststroke depression(PSD).Methods:A total of 90 PSD patients were divided into a Western medication group and a shallow needling group using the random number table,with 45 cases in each group.The Western medication group was treated with oral paroxetine tablets.The shallow needling group was treated with shallow needling at Baihui(GV20).The treatment course for both groups was 4 weeks.After treatment,the clinical efficacy was compared between the two groups.The scores of Hamilton depression scale-24(HAMD-24)and National Institutes of Health stroke scale(NIHSS),the cerebral hemodynamic changes,and the adverse reactions were observed.Results:After treatment,the total effective rate was 88.9%in the Western medication group and 84.4%in the shallow needling group;the difference between the two groups was not statistically significant(P>0.05).After treatment,the scores of HAMD-24 and NIHSS in both groups decreased(P<0.05).The difference in the HAMD-24 score between the two groups was not statistically significant(P>0.05).The NIHSS score in the shallow needling group was lower than that in the Western medication group,and the difference between the two groups was statistically significant(P<0.05).After treatment,there were no significant differences in the blood flow resistance index of the left middle cerebral artery(LMCA),right middle cerebral artery(RMCA),and basilar artery(BA)in the Western medication group compared to those before treatment.The blood flow resistance index of LMCA,RMCA,and BA in the shallow needling group was lower than that before treatment(P<0.05),and was significantly lower compared to the Western medication group(P<0.05).The incidence of adverse reactions in the shallow needling group was significantly lower than that in the Western medication group(P<0.05).Conclusion:The curative effect of shallow needling at Baihui(GV20)in the treatment of PSD is equivalent to that of oral paroxetine tablets.However,shallow needling at Baihui(GV20)is more effective in improving neurological function and cerebral perfusion,and the incidence of adverse reactions is lower.展开更多
基金the Study on the Mechanism of Action of Dutong and Tiaoshen Acupuncture in Improving Upper Limb Motor Function After Ischemic Stroke based on Functional Near-infrared Spectroscopy Technology(Science and Technology Program of Panyu,2022-Z04-107)。
文摘OBJECTIVE:To take Baihui(GV20)and Fengchi(GB20)targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating acupoints.METHODS:The target information of Baihui(GV20)and Fengchi(GB20)was retrieved,and after intersection with migraine,Kyoto Encyclopedia of Genes and Genomes(KEGG),Reactome,and Uni Prot Keywords were used for functional enrichment.After selecting the main pathway,rats were selected and nitroglycerin was used for modeling,and the behavioral scores,inflammatory factors,heme oxygenase 1(HMOX1),protein kinase B(AKT1),signal transducer and activator of transcription 3(STAT3),phosphorylated extracellular signal-regulated kinase 1/2(P-ERK1/ERK2)and other states of the rats in the acupuncture,twisting,and electroacupuncture groups were compared.RESULTS:A total of 135 Baihui(GV20)targets and 27 Fengchi(GB20)targets were collected.A total of 73 target information were obtained after the intersection of these targets in migraine.These 73 targets have three main pathways:hypoxia-inducible factor 1(HIF-1)signaling pathway,signaling by interleukins and inflammatory response.The main targets in the pathway were verified and found that interleukin-1 beta(IL-1β),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)and HMOX1,AKT1,STAT3,P-ERK1/ERK2 can be regulated by Baihui(GV20)and Fengchi(GB20).CONCLUSION:Baihui(GV20)and Fengchi(GB20)can regulate migraine by regulating inflammatory factors and HMOX1,AKT1,STAT3,P-ERK1/ERK2 and other changes in HIF-1 signaling pathway,Signaling by Interleukins and Inflammatory response pathways.Based on systems biology and network pharmacology,and with the model of"acupoint-target-disease",explore the research methods of systematic acupuncture and moxibustion.We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.
文摘Objective： To observe the therapeutic effect of suspended moxibustion at Baihui （GV 20） for insomnia. Methods： 75 cases were divided randomly into two groups, with 40 cases in the treatment group treated by suspended moxibustion over Baihui （GV 20） and 35 cases in the control group treated by oral administration of Estazolam. Results： The difference in therapeutic effect between the two groups was not statistically significant （P〉0.1）. Conelusion： It was concluded that suspended moxibustion at Baihui （GV 20） is as effective as Estazolam for insomnia.
基金Supported by National Natural Science Foundation of China:81804161,Natural Science Foundation of Jiangsu Province:BK20171070
文摘Focusing on the effect specificity of meridian points along the running course of meridian,by taking the treatment of post-stroke depression(PSD)with the acupoints of the governor vessel as an example,the correlation between meridian points and disease was explored.The specific regulatory effect of governor vessel,Baihui(百会GV20)and Shenting(神庭GV24)in physiology and pathology in PSD and the material basis of the specificity effect were analyzed.Finally,the specific relationship between the acupoints of the governor vessel and PSD was explained.
文摘Acupuncture at Baihui（GV 20）was employed in treating 32 cases of functionalenuresis.As a result,the curative rate reached 81.25％,but that in control group of 32 cases withoutneedling Baihui point was 56.25％.There was a significant difference in statistics（P【0.05）.It indi- cates that Baihui can enhance the therapeutic effect of acupuncture on treating enuresis.
文摘Objective:To observe the effects of shallow needling at Baihui(GV20)on neurological function and cerebral hemodynamics in patients with poststroke depression(PSD).Methods:A total of 90 PSD patients were divided into a Western medication group and a shallow needling group using the random number table,with 45 cases in each group.The Western medication group was treated with oral paroxetine tablets.The shallow needling group was treated with shallow needling at Baihui(GV20).The treatment course for both groups was 4 weeks.After treatment,the clinical efficacy was compared between the two groups.The scores of Hamilton depression scale-24(HAMD-24)and National Institutes of Health stroke scale(NIHSS),the cerebral hemodynamic changes,and the adverse reactions were observed.Results:After treatment,the total effective rate was 88.9%in the Western medication group and 84.4%in the shallow needling group;the difference between the two groups was not statistically significant(P>0.05).After treatment,the scores of HAMD-24 and NIHSS in both groups decreased(P<0.05).The difference in the HAMD-24 score between the two groups was not statistically significant(P>0.05).The NIHSS score in the shallow needling group was lower than that in the Western medication group,and the difference between the two groups was statistically significant(P<0.05).After treatment,there were no significant differences in the blood flow resistance index of the left middle cerebral artery(LMCA),right middle cerebral artery(RMCA),and basilar artery(BA)in the Western medication group compared to those before treatment.The blood flow resistance index of LMCA,RMCA,and BA in the shallow needling group was lower than that before treatment(P<0.05),and was significantly lower compared to the Western medication group(P<0.05).The incidence of adverse reactions in the shallow needling group was significantly lower than that in the Western medication group(P<0.05).Conclusion:The curative effect of shallow needling at Baihui(GV20)in the treatment of PSD is equivalent to that of oral paroxetine tablets.However,shallow needling at Baihui(GV20)is more effective in improving neurological function and cerebral perfusion,and the incidence of adverse reactions is lower.
