Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structu...Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structural changes in collagen linked to various pathologies.However,many approaches remain limited to conceptual descriptions or rely on custom software,often requiring programming skills,which re-stricts their clinical application and potential impact.We introduce CollagenFitJ,a plugin for the open-source software platform ImageJ/FIJI,which represents a widely used microscopy image analysis tool.CollagenFitJ makes use of the cylindrical symmetry model for collagen to enable facile quantitative assessment of polarization-resolved second harmonic generation microscopy image stacks.The plugin’s main outputs are collagen structure-related maps(e.g.,orientation and anisotropy of collagen fibrils within the focal volume),which can be accompanied by distribution and randomness maps for a series of structure-related parameters.We describe and validate the use of CollagenFitJ on images acquired on rat-tail tendons,collagen capsules surrounding human thyroid nodules,and mouse colon tumors,using both scanning and widefield second harmonic generation microscopy datasets.The plugin was designed to be user-friendly,requiring little to no experience in image processing and coding to facilitate access for life scientists,medical staff,and microscopy practitioners with limited coding skills or time availability required for coding.展开更多
Inferring the fully qualified names(FQNs)of undeclared receiving objects and non-fully-qualified type names(non-FQNs)in partial code is critical for effectively searching,understanding,and reusing partial code.Existin...Inferring the fully qualified names(FQNs)of undeclared receiving objects and non-fully-qualified type names(non-FQNs)in partial code is critical for effectively searching,understanding,and reusing partial code.Existing type inference tools,such as COSTER and SNR,rely on a symbolic knowledge base and adopt a dictionary-lookup strategy to map simple names of undeclared receiving objects and non-FQNs to FQNs.However,building a symbolic knowledge base requires parsing compilable code files,which limits the collection of APIs and code contexts,resulting in out-of-vocabulary(OOV)failures.To overcome the limitations of a symbolic knowledge base for FQN inference,we implemented Ask Me Any Type(AMAT),a type of inference plugin embedded in web browsers and integrated development environment(IDE).Unlike the dictionary-lookup strategy,AMAT uses a cloze-style fill-in-the-blank strategy for type inference.By treating code as text,AMAT leverages a fine-tuned large language model(LLM)as a neural knowledge base,thereby preventing the need for code compilation.Experimental results show that AMAT outperforms state-of-the-art tools such as COSTER and SNR.In practice,developers can directly reuse partial code by inferring the FQNs of unresolved type names in real time.展开更多
China’s new policies and new expo strengthen China-EU economic and people-to-people links.Arecent report and an important event deserve the attention of policy makers globally,coming on the eve of the EU-China summit...China’s new policies and new expo strengthen China-EU economic and people-to-people links.Arecent report and an important event deserve the attention of policy makers globally,coming on the eve of the EU-China summit in Beijing in December ahead of an uncertain new year.The document was released by the Office of the Leading Group for Promoting the Belt and Road Initiative(BRI)on November 24,2023 spelling out the vision and actions for high-quality Belt and Road cooperation during the next decade.展开更多
Purpose:The interdisciplinary nature and rapid development of the Semantic Web led to the mass publication of RDF data in a large number of widely accepted serialization formats,thus developing out the necessity for R...Purpose:The interdisciplinary nature and rapid development of the Semantic Web led to the mass publication of RDF data in a large number of widely accepted serialization formats,thus developing out the necessity for RDF data processing with specific purposes.The paper reports on an assessment of chief RDF data endpoint challenges and introduces the RDF Adaptor,a set of plugins for RDF data processing which covers the whole life-cycle with high efficiency.Design/methodology/approach:The RDFAdaptor is designed based on the prominent ETL tool—Pentaho Data Integration—which provides a user-friendly and intuitive interface and allows connect to various data sources and formats,and reuses the Java framework RDF4J as middleware that realizes access to data repositories,SPARQL endpoints and all leading RDF database solutions with SPARQL 1.1 support.It can support effortless services with various configuration templates in multi-scenario applications,and help extend data process tasks in other services or tools to complement missing functions.Findings:The proposed comprehensive RDF ETL solution—RDFAdaptor—provides an easy-to-use and intuitive interface,supports data integration and federation over multi-source heterogeneous repositories or endpoints,as well as manage linked data in hybrid storage mode.Research limitations:The plugin set can support several application scenarios of RDF data process,but error detection/check and interaction with other graph repositories remain to be improved.Practical implications:The plugin set can provide user interface and configuration templates which enable its usability in various applications of RDF data generation,multi-format data conversion,remote RDF data migration,and RDF graph update in semantic query process.Originality/value:This is the first attempt to develop components instead of systems that can include extract,consolidate,and store RDF data on the basis of an ecologically mature data warehousing environment.展开更多
Ecotourism is a sustainable, green and smokeless industry of the society by providing alternative source to the livelihood and local community, in order to re-naturalize the environment to bring the man closer to the ...Ecotourism is a sustainable, green and smokeless industry of the society by providing alternative source to the livelihood and local community, in order to re-naturalize the environment to bring the man closer to the natural environment. The use of web application has changed the way tourists gather information about tourist attraction spots of the research area. The aim of the study is to assess and identify ecotourism attraction sites of Chokie Mountain watersheds for touristic activities to develop a web-based GIS mapping portal for the improvement of nature-based ecotourism activities. The web-based GIS portal for Web Mapping Application is available for the user with the skills necessary to create standard web mapping services. We have implemented web mapping services based on formal cartographic visualization rules in the open source QGIS software and threejs JavaScript plugin. Threejs plugin is used for 3D visualization, interaction and export terrain data, map canvas image and vector data to HTML page and JS. The result of web-based GIS portal supports spatial and non-spatial database of tourist attraction and tourist service data with attractive user interface.展开更多
Recently,a report explaining the construction of a Human Pangenome ANalysis(HUPAN)system attracted wide attention in the biomedicine community.The original article was published in Genome Biology,a leading internation...Recently,a report explaining the construction of a Human Pangenome ANalysis(HUPAN)system attracted wide attention in the biomedicine community.The original article was published in Genome Biology,a leading international journal in genomics1.Many researchers,particularly those conducting basic medical research.展开更多
The origin of ancient banded iron formation （BIF） has remained unclear for a long time. How the precipitation process occurred and what the environmental condition was have been widely discussed among scientists, be...The origin of ancient banded iron formation （BIF） has remained unclear for a long time. How the precipitation process occurred and what the environmental condition was have been widely discussed among scientists, because the period when the major BIFs deposited （-2.8 to 1.8Ga） is the same time when biosphere and atmosphere significantly changed. Based on the discovery of modern seafloor hydrothermal vents, it is possible that reductive environment controlled by vent system is related to the environment where BIF was deposited. According to matter source.展开更多
A theoretical model which couples the oscillation of cavitation bubbles with the equation of an acoustic wave is utilized to describe the sound fields in double-layer liquids, which can be used to realize the asymmetr...A theoretical model which couples the oscillation of cavitation bubbles with the equation of an acoustic wave is utilized to describe the sound fields in double-layer liquids, which can be used to realize the asymmetric transmission of acoustic waves. Numerical simulations show that the asymmetry is related to the properties of the host liquids and the input acoustic wave. Asymmetry can be enhanced if the maximum number density or the ambient radius of the cavitation bubbles in the low cavitation threshold liquid increases. Moreover, the direction of rectification will be reversed if the amplitude of the input acoustic wave becomes high enough.展开更多
The authors want to changed the web link of the software platform in this Briefing.Page 97,section 'INTRODUCTION',the web link of SHEsis is changed from http://www.nhgg.org/analysis tohttp://analysis.bio-x.
The power conversion efficiency(PCE)for perovskite solar cells(PSCs)now reaches 25.2%[1].However,the perovskite materials have complex compositions and variable phases,calling for suitable characterization techniques ...The power conversion efficiency(PCE)for perovskite solar cells(PSCs)now reaches 25.2%[1].However,the perovskite materials have complex compositions and variable phases,calling for suitable characterization techniques to investigate the underlying operation and degradation mechanism.展开更多
To the editor,Since the introduction of multiplex-PCR(mPCR)in1988,this technique has emerged as a highly efficient and sensitive molecular tool for nucleic acid-based diagnosis and monitoring,it is applicable to a bro...To the editor,Since the introduction of multiplex-PCR(mPCR)in1988,this technique has emerged as a highly efficient and sensitive molecular tool for nucleic acid-based diagnosis and monitoring,it is applicable to a broad range of physiological,metabolic and infectious conditions affecting human。展开更多
The authors consider the uniformly most powerful invariant test of the testing problems (Ⅰ) H 0: μ′Σ -1 μ≥CH 1: μ′Σ -1 μ<C and (Ⅱ) H 00 : β′X′Xβσ 2≥CH 11 : β′X′Xβσ 2<C u...The authors consider the uniformly most powerful invariant test of the testing problems (Ⅰ) H 0: μ′Σ -1 μ≥CH 1: μ′Σ -1 μ<C and (Ⅱ) H 00 : β′X′Xβσ 2≥CH 11 : β′X′Xβσ 2<C under m dimensional normal population N m(μ, Σ) and normal linear model (Y, Xβ, σ 2) respectively. Furthermore, an application of the uniformly most powerful invariant test is given.展开更多
The term of office shifting National two sessions in 2018, the First Session of the 13th National People＇s Congress （NPC） and the First Session of the National Committee of Chinese People＇s Political Consultative ...The term of office shifting National two sessions in 2018, the First Session of the 13th National People＇s Congress （NPC） and the First Session of the National Committee of Chinese People＇s Political Consultative Conference （CPPCC） were held at a new historical juncture for China＇s development. It was described by the international public opinions as ＂the first two sessions since the 19th Communist Party of China（CPC） National Congress declaring China＇s entry into a new era＂, marking ＂the most important moment for China in 2o18＂ and having extraor- dinary significance and far-reaching impact.展开更多
基金supported by the Ministry of Research,Innovation and Digitalization,CNCS-UEFISCDI[Grant Nos.RO-NO-2019-0601(MEDYCONAI),PN-III-P4-PCE-2021-0444(RESONANO)]PN-IV-P1-PCE-2023-1137+2 种基金supported in part by IN2SIGHT,European Union’s Horizon 2020(GA.no.964481)by the Research Council of Lithuania(LMTLTAgreement No.P-MIP-23-237).
文摘Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structural changes in collagen linked to various pathologies.However,many approaches remain limited to conceptual descriptions or rely on custom software,often requiring programming skills,which re-stricts their clinical application and potential impact.We introduce CollagenFitJ,a plugin for the open-source software platform ImageJ/FIJI,which represents a widely used microscopy image analysis tool.CollagenFitJ makes use of the cylindrical symmetry model for collagen to enable facile quantitative assessment of polarization-resolved second harmonic generation microscopy image stacks.The plugin’s main outputs are collagen structure-related maps(e.g.,orientation and anisotropy of collagen fibrils within the focal volume),which can be accompanied by distribution and randomness maps for a series of structure-related parameters.We describe and validate the use of CollagenFitJ on images acquired on rat-tail tendons,collagen capsules surrounding human thyroid nodules,and mouse colon tumors,using both scanning and widefield second harmonic generation microscopy datasets.The plugin was designed to be user-friendly,requiring little to no experience in image processing and coding to facilitate access for life scientists,medical staff,and microscopy practitioners with limited coding skills or time availability required for coding.
基金Supported by the Key Scientific and Technological Research Projects of the Jiangxi Provincial Department of Education(GJJ2200303)the National Social Science Foundation Major Bidding Project(20&ZD068)。
文摘Inferring the fully qualified names(FQNs)of undeclared receiving objects and non-fully-qualified type names(non-FQNs)in partial code is critical for effectively searching,understanding,and reusing partial code.Existing type inference tools,such as COSTER and SNR,rely on a symbolic knowledge base and adopt a dictionary-lookup strategy to map simple names of undeclared receiving objects and non-FQNs to FQNs.However,building a symbolic knowledge base requires parsing compilable code files,which limits the collection of APIs and code contexts,resulting in out-of-vocabulary(OOV)failures.To overcome the limitations of a symbolic knowledge base for FQN inference,we implemented Ask Me Any Type(AMAT),a type of inference plugin embedded in web browsers and integrated development environment(IDE).Unlike the dictionary-lookup strategy,AMAT uses a cloze-style fill-in-the-blank strategy for type inference.By treating code as text,AMAT leverages a fine-tuned large language model(LLM)as a neural knowledge base,thereby preventing the need for code compilation.Experimental results show that AMAT outperforms state-of-the-art tools such as COSTER and SNR.In practice,developers can directly reuse partial code by inferring the FQNs of unresolved type names in real time.
文摘China’s new policies and new expo strengthen China-EU economic and people-to-people links.Arecent report and an important event deserve the attention of policy makers globally,coming on the eve of the EU-China summit in Beijing in December ahead of an uncertain new year.The document was released by the Office of the Leading Group for Promoting the Belt and Road Initiative(BRI)on November 24,2023 spelling out the vision and actions for high-quality Belt and Road cooperation during the next decade.
基金This work is supported by“National Social Science Foundation in China”Project(19BTQ061)“Integration and Development on A Next Generation of Open Knowledge Services System and Key Technologies”project(2020XM05).
文摘Purpose:The interdisciplinary nature and rapid development of the Semantic Web led to the mass publication of RDF data in a large number of widely accepted serialization formats,thus developing out the necessity for RDF data processing with specific purposes.The paper reports on an assessment of chief RDF data endpoint challenges and introduces the RDF Adaptor,a set of plugins for RDF data processing which covers the whole life-cycle with high efficiency.Design/methodology/approach:The RDFAdaptor is designed based on the prominent ETL tool—Pentaho Data Integration—which provides a user-friendly and intuitive interface and allows connect to various data sources and formats,and reuses the Java framework RDF4J as middleware that realizes access to data repositories,SPARQL endpoints and all leading RDF database solutions with SPARQL 1.1 support.It can support effortless services with various configuration templates in multi-scenario applications,and help extend data process tasks in other services or tools to complement missing functions.Findings:The proposed comprehensive RDF ETL solution—RDFAdaptor—provides an easy-to-use and intuitive interface,supports data integration and federation over multi-source heterogeneous repositories or endpoints,as well as manage linked data in hybrid storage mode.Research limitations:The plugin set can support several application scenarios of RDF data process,but error detection/check and interaction with other graph repositories remain to be improved.Practical implications:The plugin set can provide user interface and configuration templates which enable its usability in various applications of RDF data generation,multi-format data conversion,remote RDF data migration,and RDF graph update in semantic query process.Originality/value:This is the first attempt to develop components instead of systems that can include extract,consolidate,and store RDF data on the basis of an ecologically mature data warehousing environment.
文摘Ecotourism is a sustainable, green and smokeless industry of the society by providing alternative source to the livelihood and local community, in order to re-naturalize the environment to bring the man closer to the natural environment. The use of web application has changed the way tourists gather information about tourist attraction spots of the research area. The aim of the study is to assess and identify ecotourism attraction sites of Chokie Mountain watersheds for touristic activities to develop a web-based GIS mapping portal for the improvement of nature-based ecotourism activities. The web-based GIS portal for Web Mapping Application is available for the user with the skills necessary to create standard web mapping services. We have implemented web mapping services based on formal cartographic visualization rules in the open source QGIS software and threejs JavaScript plugin. Threejs plugin is used for 3D visualization, interaction and export terrain data, map canvas image and vector data to HTML page and JS. The result of web-based GIS portal supports spatial and non-spatial database of tourist attraction and tourist service data with attractive user interface.
基金supported by grants from the National Key R&D Program of China(Grant No.2017YFC0908300 and 2016YFC1303200)the National Natural Science Foundation of China(Grant No.81772505 and J1210047)+4 种基金the Shanghai Science and Technology Committee(Grant No.18411953100)the Cross-Institute Research Fund of Shanghai Jiao Tong University(Grant No.YG2017ZD01)the Innovation Foundation of Translational Medicine of Shanghai Jiao Tong University School of Medicine(Grant No.15ZH4001,TM201617,and TM 201702)Neil Shen’s SJTU Medical Research Fundthe SJTU-Yale Collaborative Research Seed Fund。
文摘Recently,a report explaining the construction of a Human Pangenome ANalysis(HUPAN)system attracted wide attention in the biomedicine community.The original article was published in Genome Biology,a leading international journal in genomics1.Many researchers,particularly those conducting basic medical research.
基金supported by National Natural Science Foundation of China(grant No.41376077)Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB06020204)the National Key Basic Research Program of China(grant No.2013CB429703)
文摘The origin of ancient banded iron formation （BIF） has remained unclear for a long time. How the precipitation process occurred and what the environmental condition was have been widely discussed among scientists, because the period when the major BIFs deposited （-2.8 to 1.8Ga） is the same time when biosphere and atmosphere significantly changed. Based on the discovery of modern seafloor hydrothermal vents, it is possible that reductive environment controlled by vent system is related to the environment where BIF was deposited. According to matter source.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11334005,11574150 and 11564006
文摘A theoretical model which couples the oscillation of cavitation bubbles with the equation of an acoustic wave is utilized to describe the sound fields in double-layer liquids, which can be used to realize the asymmetric transmission of acoustic waves. Numerical simulations show that the asymmetry is related to the properties of the host liquids and the input acoustic wave. Asymmetry can be enhanced if the maximum number density or the ambient radius of the cavitation bubbles in the low cavitation threshold liquid increases. Moreover, the direction of rectification will be reversed if the amplitude of the input acoustic wave becomes high enough.
文摘The authors want to changed the web link of the software platform in this Briefing.Page 97,section 'INTRODUCTION',the web link of SHEsis is changed from http://www.nhgg.org/analysis tohttp://analysis.bio-x.
基金supported by National Natural Science Foundation of China(21975028,22011540377)Beijing Municipal Science and Technology Project(Z181100005118002)+2 种基金Beijing Municipal Natural Science Foundation(JQ19008)National Key Research and Development Program of China(2017YFA0206600)the National Natur-al Science Foundation of China(51773045,21772030,51922032,21961160720)for financial support。
文摘The power conversion efficiency(PCE)for perovskite solar cells(PSCs)now reaches 25.2%[1].However,the perovskite materials have complex compositions and variable phases,calling for suitable characterization techniques to investigate the underlying operation and degradation mechanism.
文摘To the editor,Since the introduction of multiplex-PCR(mPCR)in1988,this technique has emerged as a highly efficient and sensitive molecular tool for nucleic acid-based diagnosis and monitoring,it is applicable to a broad range of physiological,metabolic and infectious conditions affecting human。
文摘The authors consider the uniformly most powerful invariant test of the testing problems (Ⅰ) H 0: μ′Σ -1 μ≥CH 1: μ′Σ -1 μ<C and (Ⅱ) H 00 : β′X′Xβσ 2≥CH 11 : β′X′Xβσ 2<C under m dimensional normal population N m(μ, Σ) and normal linear model (Y, Xβ, σ 2) respectively. Furthermore, an application of the uniformly most powerful invariant test is given.
文摘The term of office shifting National two sessions in 2018, the First Session of the 13th National People＇s Congress （NPC） and the First Session of the National Committee of Chinese People＇s Political Consultative Conference （CPPCC） were held at a new historical juncture for China＇s development. It was described by the international public opinions as ＂the first two sessions since the 19th Communist Party of China（CPC） National Congress declaring China＇s entry into a new era＂, marking ＂the most important moment for China in 2o18＂ and having extraor- dinary significance and far-reaching impact.
