BACKGROUND Chronic obstructive pulmonary disease(COPD)is a chronic respiratory disease with worldwide occurrence and high disability and mortality rate.It occurs mostly in the elderly population with pulmonary heart d...BACKGROUND Chronic obstructive pulmonary disease(COPD)is a chronic respiratory disease with worldwide occurrence and high disability and mortality rate.It occurs mostly in the elderly population with pulmonary heart disease,type II respiratory failure,and other serious complications.AIM To investigate the correlation of plasma brain natriuretic peptide(BNP)and platelet parameters with cardiac function and pulmonary hypertension in patients with COPD and pulmonary heart disease.METHODS From June 2016 to June 2019,52 patients with COPD-pulmonary heart disease(pulmonary heart disease group),30 patients with COPD(COPD group),and 30 healthy individuals(control group)in our hospital were enrolled in the study.The pulmonary heart disease group was further divided into subgroups according to cardiac function classification and pulmonary artery pressure.Plasma BNP and platelet parameters were estimated and compared among each group and subgroup.The correlation of plasma BNP and platelet parameters with cardiac function classification and pulmonary artery pressure was then analyzed.RESULTS In the pulmonary heart disease group,the COPD group,and the control group,the levels of plasma BNP,platelet distribution width(PDW),and mean platelet volume(MPV)showed a decreasing trend(P<0.05),while an increasing trend was found in platelet count(PLT)and plateletcrit(PCT)levels among the three groups(P<0.05).In the pulmonary hypertension mild,moderate,and severe subgroups,the levels of plasma BNP,PDW,and MPV showed an increasing trend(P<0.05),while a decreasing trend was observed in PLT levels(P<0.05);however,PCT levels showed no significant difference among the three subgroups(P>0.05).In the cardiac function grade I,II,III,and IV subgroups,the levels of plasma BNP,PDW,and MPV showed an increasing trend(P<0.05),while a decreasing trend was noted in PLT and PCT levels among the four subgroups(P<0.05).Correlation analysis showed that the levels of plasma BNP,PDW,and MPV in patients with pulmonary heart disease were positively correlated with their pulmonary artery pressure(P<0.05),while PLT was negatively correlated with their pulmonary artery pressure(P<0.05).Moreover,plasma BNP,PDW,and MPV levels were positively correlated with cardiac function grade(P<0.05)of these patients,while PLT and PCT levels were negatively correlated with their cardiac function grade(P<0.05).CONCLUSION Plasma BNP and PLT parameters are significantly correlated with the cardiac function and pulmonary hypertension in patients with COPD and pulmonary heart disease,indicating that these parameters have high clinical relevance in reflecting the health condition of these patients and for guiding their treatment.展开更多
With the continuous innovation of science and technology, and the continuous improvement of platelet testing instruments, platelet parameters (PLT, PDW, PCT, MPV) have been paid more and more attention in clinical pra...With the continuous innovation of science and technology, and the continuous improvement of platelet testing instruments, platelet parameters (PLT, PDW, PCT, MPV) have been paid more and more attention in clinical practice, which is characterized by convenience and availability. Platelets are blood cells formed by the exfoliation of the original megakaryocytes in the bone marrow after maturation, and have the most prominent hemostatic function in the body. The process of its hemostasis function is mainly divided into two steps: the first step is that after the rupture of the intima of the blood vessel, the platelet agglutinates rapidly and forms soft thrombus in the breach;The second step is mainly to promote the coagulation of blood and form a hard and stable thrombus at the breach of the intima. The related parameters represent some characteristics of platelets.展开更多
Objective: to explore the clinical value of platelet parameters and bone marrow smear for blood disease test. Methods: the 132 patients receiving platelet parameters and bone marrow smear test in our hospital were eve...Objective: to explore the clinical value of platelet parameters and bone marrow smear for blood disease test. Methods: the 132 patients receiving platelet parameters and bone marrow smear test in our hospital were evenly divided into 2 groups of 66 patients, namely control group (healthy population) and observation group (patients with blood diseases), with 33 patients in each group. The admission time was from July 1, 2020 to August 1, 2021. Results: the mean hematocrit (14.74 ± 3.19) FL and platelet volume distribution width (18.36 ± 1.38)% of the observation group were higher than those of the control group, while the platelet count of the observation group was significantly lower than that of the control group (239.64 ± 8.35)%, and the hematocrit was also lower than that of the control group (215.38 ± 5.36)*109. There was significant difference in platelet parameters between the two groups (P < 0.05);Compared with the control group, the distribution of platelets in the observation group was rare, single and occasional, the degree of bone marrow hyperplasia was more active, and megakaryocytes were immature megakaryocytes. Conclusion: through the platelet parameters combined with bone marrow smear test, it is found that there are significant changes in the relevant parameters of blood diseases and healthy people. Clinical test can provide an important basis for clinical treatment and contribute to the early detection of blood diseases.展开更多
Objective:To explore the effect of composite salvia injection(CSI) on platelet parameters in children with anaphylactoid purpura(AP) and its clinical significance.Methods:One hundred and fifty children with AP were as...Objective:To explore the effect of composite salvia injection(CSI) on platelet parameters in children with anaphylactoid purpura(AP) and its clinical significance.Methods:One hundred and fifty children with AP were assigned to two groups,80 in Group A and 70 in Group B.They were treated,respectively,with conventional therapy only or conventional therapy combined with CSI.Their platelet parameters,including blood platelet count(BPC),mean platelet volume(MPV),platelet distribution width(PDW) and plateletcrit(...展开更多
文摘BACKGROUND Chronic obstructive pulmonary disease(COPD)is a chronic respiratory disease with worldwide occurrence and high disability and mortality rate.It occurs mostly in the elderly population with pulmonary heart disease,type II respiratory failure,and other serious complications.AIM To investigate the correlation of plasma brain natriuretic peptide(BNP)and platelet parameters with cardiac function and pulmonary hypertension in patients with COPD and pulmonary heart disease.METHODS From June 2016 to June 2019,52 patients with COPD-pulmonary heart disease(pulmonary heart disease group),30 patients with COPD(COPD group),and 30 healthy individuals(control group)in our hospital were enrolled in the study.The pulmonary heart disease group was further divided into subgroups according to cardiac function classification and pulmonary artery pressure.Plasma BNP and platelet parameters were estimated and compared among each group and subgroup.The correlation of plasma BNP and platelet parameters with cardiac function classification and pulmonary artery pressure was then analyzed.RESULTS In the pulmonary heart disease group,the COPD group,and the control group,the levels of plasma BNP,platelet distribution width(PDW),and mean platelet volume(MPV)showed a decreasing trend(P<0.05),while an increasing trend was found in platelet count(PLT)and plateletcrit(PCT)levels among the three groups(P<0.05).In the pulmonary hypertension mild,moderate,and severe subgroups,the levels of plasma BNP,PDW,and MPV showed an increasing trend(P<0.05),while a decreasing trend was observed in PLT levels(P<0.05);however,PCT levels showed no significant difference among the three subgroups(P>0.05).In the cardiac function grade I,II,III,and IV subgroups,the levels of plasma BNP,PDW,and MPV showed an increasing trend(P<0.05),while a decreasing trend was noted in PLT and PCT levels among the four subgroups(P<0.05).Correlation analysis showed that the levels of plasma BNP,PDW,and MPV in patients with pulmonary heart disease were positively correlated with their pulmonary artery pressure(P<0.05),while PLT was negatively correlated with their pulmonary artery pressure(P<0.05).Moreover,plasma BNP,PDW,and MPV levels were positively correlated with cardiac function grade(P<0.05)of these patients,while PLT and PCT levels were negatively correlated with their cardiac function grade(P<0.05).CONCLUSION Plasma BNP and PLT parameters are significantly correlated with the cardiac function and pulmonary hypertension in patients with COPD and pulmonary heart disease,indicating that these parameters have high clinical relevance in reflecting the health condition of these patients and for guiding their treatment.
文摘With the continuous innovation of science and technology, and the continuous improvement of platelet testing instruments, platelet parameters (PLT, PDW, PCT, MPV) have been paid more and more attention in clinical practice, which is characterized by convenience and availability. Platelets are blood cells formed by the exfoliation of the original megakaryocytes in the bone marrow after maturation, and have the most prominent hemostatic function in the body. The process of its hemostasis function is mainly divided into two steps: the first step is that after the rupture of the intima of the blood vessel, the platelet agglutinates rapidly and forms soft thrombus in the breach;The second step is mainly to promote the coagulation of blood and form a hard and stable thrombus at the breach of the intima. The related parameters represent some characteristics of platelets.
文摘Objective: to explore the clinical value of platelet parameters and bone marrow smear for blood disease test. Methods: the 132 patients receiving platelet parameters and bone marrow smear test in our hospital were evenly divided into 2 groups of 66 patients, namely control group (healthy population) and observation group (patients with blood diseases), with 33 patients in each group. The admission time was from July 1, 2020 to August 1, 2021. Results: the mean hematocrit (14.74 ± 3.19) FL and platelet volume distribution width (18.36 ± 1.38)% of the observation group were higher than those of the control group, while the platelet count of the observation group was significantly lower than that of the control group (239.64 ± 8.35)%, and the hematocrit was also lower than that of the control group (215.38 ± 5.36)*109. There was significant difference in platelet parameters between the two groups (P < 0.05);Compared with the control group, the distribution of platelets in the observation group was rare, single and occasional, the degree of bone marrow hyperplasia was more active, and megakaryocytes were immature megakaryocytes. Conclusion: through the platelet parameters combined with bone marrow smear test, it is found that there are significant changes in the relevant parameters of blood diseases and healthy people. Clinical test can provide an important basis for clinical treatment and contribute to the early detection of blood diseases.
文摘Objective:To explore the effect of composite salvia injection(CSI) on platelet parameters in children with anaphylactoid purpura(AP) and its clinical significance.Methods:One hundred and fifty children with AP were assigned to two groups,80 in Group A and 70 in Group B.They were treated,respectively,with conventional therapy only or conventional therapy combined with CSI.Their platelet parameters,including blood platelet count(BPC),mean platelet volume(MPV),platelet distribution width(PDW) and plateletcrit(...
