The breast cancer ecosystem represents a complex network of cellular and molecular interactions orchestrating tumor progression and therapeutic resistance.Herein,metabolic reprogramming and exosomes have emerged as pi...The breast cancer ecosystem represents a complex network of cellular and molecular interactions orchestrating tumor progression and therapeutic resistance.Herein,metabolic reprogramming and exosomes have emerged as pivotal factors,shaping the tumor microenvironment(TME)and driving cancer advancement.Breast cancer cells exhibit metabolic plasticity,engaging in diverse metabolic adaptations beyond the Warburg effect to ensure survival under nutrient stress and maintain aggressive phenotypes.Exosomes,facilitating intercellular communication,further contribute to this complexity within the TME.展开更多
基金supported by the Wenzhou Major Science&Technology Innovation Project of Wenzhou(ZY2022017)the Summit Advancement Disciplines of Zhejiang Province(Wenzhou Medical University-Pharmaceutics)+3 种基金the Natural Science Foundation of Zhejiang Province(LTGY23H100001)Science and Technology Plan Project of Wenzhou Municipality,China(Y20220389 and Y20220045)the National Natural Science Foundation of China(12325405 and 22307098)the National Key Research and Development Program of China(2022YFA1405002).
文摘The breast cancer ecosystem represents a complex network of cellular and molecular interactions orchestrating tumor progression and therapeutic resistance.Herein,metabolic reprogramming and exosomes have emerged as pivotal factors,shaping the tumor microenvironment(TME)and driving cancer advancement.Breast cancer cells exhibit metabolic plasticity,engaging in diverse metabolic adaptations beyond the Warburg effect to ensure survival under nutrient stress and maintain aggressive phenotypes.Exosomes,facilitating intercellular communication,further contribute to this complexity within the TME.
