Compared with the traditional rigid plastic/rigid viscoplastic(RP/RVP) FEM(based on iteration solution),RP/RVP FEM based on linear programming (LP) has some remarkable advantages,such as it's free of convergence...Compared with the traditional rigid plastic/rigid viscoplastic(RP/RVP) FEM(based on iteration solution),RP/RVP FEM based on linear programming (LP) has some remarkable advantages,such as it's free of convergence problem and its convenience in contact,rigid zone,and friction force treatment.The numerical model of RP/RVP FEM based on LP for axisymmetrical metal forming simulation is studied,and some related key factors and its treatment methods in formulation of constraint condition are proposed.Some solution examples are provided to validate its accuracy and efficiency.展开更多
A new rigid-plastic/rigid-viscoplastic (RP/RVP) FEM based on linearprogramming (LP) for plane-strain metal forming simulation is proposed. Compared with thetraditional RP/RVP FEM based on iteration solution, it has so...A new rigid-plastic/rigid-viscoplastic (RP/RVP) FEM based on linearprogramming (LP) for plane-strain metal forming simulation is proposed. Compared with thetraditional RP/RVP FEM based on iteration solution, it has some remarkable advantages, such a it'sfree of convergence problem and its convenience in contact, incompressibility constraint and rigidzone treatment. Two solution examples are provided to validate its accuracy and efficiency.展开更多
Neuronal plasticity,the brain's ability to adapt structurally and functionally,is essential for learning,memory,and recovery from injuries.In neurodegenerative diseases such as Alzheimer's disease and Parkinso...Neuronal plasticity,the brain's ability to adapt structurally and functionally,is essential for learning,memory,and recovery from injuries.In neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease,this plasticity is disrupted,leading to cognitive and motor deficits.This review explores the mechanisms of neuronal plasticity and its effect on Alzheimer's disease and Parkinson's disease.Alzheimer's disease features amyloid-beta plaques and tau tangles that impair synaptic function,while Parkinson's disease involves the loss of dopaminergic neurons affecting motor control.Enhancing neuronal plasticity offers therapeutic potential for these diseases.A systematic literature review was conducted using databases such as PubMed,Scopus,and Google Scholar,focusing on studies of neuronal plasticity in Alzheimer's disease and Parkinson's disease.Data synthesis identified key themes such as synaptic mechanisms,neurogenesis,and therapeutic strategies,linking molecular insights to clinical applications.Results highlight that targeting synaptic plasticity mechanisms,such as long-term potentiation and long-term depression,shows promise.Neurotrophic factors,advanced imaging techniques,and molecular tools(e.g.,clustered regularly interspaced short palindromic repeats and optogenetics)are crucial in understanding and enhancing plasticity.Current therapies,including dopamine replacement,deep brain stimulation,and lifestyle interventions,demonstrate the potential to alleviate symptoms and improve outcomes.In conclusion,enhancing neuronal plasticity through targeted therapies holds significant promise for treating neurodegenerative diseases.Future research should integrate multidisciplinary approaches to fully harness the therapeutic potential of neuronal plasticity in Alzheimer's disease and Parkinson's disease.展开更多
The dentate gyrus of the hippocampus is a plastic structure that displays modifications at different levels in response to positive stimuli as well as to negative conditions such as brain damage.The latter involves gl...The dentate gyrus of the hippocampus is a plastic structure that displays modifications at different levels in response to positive stimuli as well as to negative conditions such as brain damage.The latter involves global alterations,making understanding plastic responses triggered by local damage difficult.One key feature of the dentate gyrus is that it contains a well-defined neurogenic niche,the subgranular zone,and beyond neurogenesis,newly born granule cells may maintain a“young”phenotype throughout life,adding to the plastic nature of the structure.Here,we present a novel experimental model of local brain damage in organotypic entorhino-hippocampal cultures that results in the activation of adjacent newly born granule cells.A small piece of filter paper was placed on the surface of the granule cell layer of the dentate gyrus,which evoked a foreign body reaction of astrocytes,along with the activation of local young neurons expressing doublecortin.Forty-eight hours after foreign body placement,the number of doublecortin-immunoreactive cells increased in the subgranular zone in the direct vicinity of the foreign body,whereas overall increased doublecortin immunoreactivity was observed in the granule cell layer and molecular layer of the dentate gyrus.Foreign body placement in the pyramidal layer of the CA1 region evoked a comparable local astroglial reaction but did not lead to an increase in doublecortin-immunoreactive in either the CA1 region or the adjacent dentate gyrus.Seven days after foreign body placement in the dentate gyrus,the increase in doublecortin-immunoreactivity was no longer observed,indicating the transient activation of young cells.However,7 days after foreign body placement,the number of doublecortin-immunoreactive granule cells coimmunoreactive for calbindin was lower than that under the control conditions.As calbindin is a marker for mature granule cells,this result suggests that activated young cells remain at a more immature stage following foreign body placement.Live imaging of retrovirally green fluorescent protein-labeled newly born granule cells revealed the orientation and growth of their dendrites toward the foreign body placement.This novel experimental model of foreign body placement in organotypic entorhino-hippocampal cultures could serve as a valuable tool for studying both glial reactivity and neuronal plasticity,specifically of newly born neurons under controlled in vitro conditions.展开更多
Oxygen reduction reaction(ORR)is crucial for Znair batteries,while also serves as a core electrochemical process in oxygen depolarized cathodes(ODCs)for chlor-alkali electrolysis.The lack of cost-effective,highly acti...Oxygen reduction reaction(ORR)is crucial for Znair batteries,while also serves as a core electrochemical process in oxygen depolarized cathodes(ODCs)for chlor-alkali electrolysis.The lack of cost-effective,highly active ORR electrocatalysts with superior kinetics hinders progress in this field.Herein,we report the Fe/Ni dual single-atomic sites anchored by commercial carbon black(Fe/Ni-N/CB)using rigid ligand confined and high-temperature shock(HTS)strategy in less than 0.5 s.Theoretical calculation reveals that singleatomic Fe is the real active site.Single-atomic Fe and Ni species in Fe/Ni-N/CB synergistically accelerate the kinetics of ORR by reducing the energy barrier of the rate-determining step.A large half-wave potential(E_(1/2))of 0.907 V is achieved in 0.1 M KOH aqueous solution.The assembled aqueous Zn-air battery(A-ZAB)with Fe/Ni-N/CB cathode presents remarkable charge-discharge cycling stability for over 650 h without voltage gap degradation.The quasi-solid-state Zn-air battery(QSS-ZAB)exhibits excellent reversibility over a 150-h operation at 0.5 mA·cm^(-2) with negligible energy conversion efficiency recession.Impressively,Fe/Ni-N/CB||RuO_(2)chloralkali flow cell exhibits a low cell voltage of 1.60 V at a large current density of 300 mA·cm^(-2) at 80℃,and demonstrates exceptional durability with 7% current density decay over 150 h of continuous operation at 100 mA·cm^(-2).Fe/Ni-N/CB||RuO_(2)achieves near-ideal caustic current efficiency(~97.2%)at the current density of 300 mA·cm^(-2).This work provides a rapid and economical synthesis technique for the synthesis of catalysts at the atomic scale while demonstrating significant potential for application in energy-saving chlor-alkali electrolyzer.展开更多
The capacity of the central nervous system for structural plasticity and regeneration is commonly believed to show a decreasing progression from“small and simple”brains to the larger,more complex brains of mammals.H...The capacity of the central nervous system for structural plasticity and regeneration is commonly believed to show a decreasing progression from“small and simple”brains to the larger,more complex brains of mammals.However,recent findings revealed that some forms of neural plasticity can show a reverse trend.Although plasticity is a well-preserved,transversal feature across the animal world,a variety of cell populations and mechanisms seem to have evolved to enable structural modifications to take place in widely different brains,likely as adaptations to selective pressures.Increasing evidence now indicates that a trade-off has occurred between regenerative(mostly stem cell–driven)plasticity and developmental(mostly juvenile)remodeling,with the latter primarily aimed not at brain repair but rather at“sculpting”the neural circuits based on experience.In particular,an evolutionary trade-off has occurred between neurogenic processes intended to support the possibility of recruiting new neurons throughout life and the different ways of obtaining new neurons,and between the different brain locations in which plasticity occurs.This review first briefly surveys the different types of plasticity and the complexity of their possible outcomes and then focuses on recent findings showing that the mammalian brain has a stem cell–independent integration of new neurons into pre-existing(mature)neural circuits.This process is still largely unknown but involves neuronal cells that have been blocked in arrested maturation since their embryonic origin(also termed“immature”or“dormant”neurons).These cells can then restart maturation throughout the animal's lifespan to become functional neurons in brain regions,such as the cerebral cortex and amygdala,that are relevant to high-order cognition and emotions.Unlike stem cell–driven postnatal/adult neurogenesis,which significantly decreases from small-brained,short-living species to large-brained ones,immature neurons are particularly abundant in large-brained,long-living mammals,including humans.The immature neural cell populations hosted in these complex brains are an interesting example of an“enlarged road”in the phylogenetic trend of plastic potential decreases commonly observed in the animal world.The topic of dormant neurons that covary with brain size and gyrencephaly represents a prospective turning point in the field of neuroplasticity,with important translational outcomes.These cells can represent a reservoir of undifferentiated neurons,potentially granting plasticity within the high-order circuits subserving the most sophisticated cognitive skills that are important in the growing brains of young,healthy individuals and are frequently affected by debilitating neurodevelopmental and degenerative disorders.展开更多
Regenerative capacity of the central nervous system(CNS)is unevenly distributed among vertebrates.While most mammalian species including humans elicit limited repair following CNS injury or disease,highly regenerative...Regenerative capacity of the central nervous system(CNS)is unevenly distributed among vertebrates.While most mammalian species including humans elicit limited repair following CNS injury or disease,highly regenerative vertebrates including urodele amphibians and teleost fish spontaneously reverse CNS damage.Teletost zebrafish(danio rerio)are tropical freshwater fish that proved to be an excellent vertebrate model of successful CNS regeneration.Differential neuronal,glial,and immune injury responses underlie disparate injury outcomes between highly regenerative zebrafish and poorly regenerative mammals.This article describes complications associated with neuronal repair following spinal cord injury(SCI)in poorly regenerative mammals and highlights intersecting modes of plasticity and regeneration in highly regenerative zebrafish(Figures 1 and 2).Comparative approaches evaluating immunoglial SCI responses were recently reviewed elsewhere(Reyes and Mokalled,2024).展开更多
The remodeling of axonal connections following injury is an important feature driving functional recovery.The reticulospinal tract is an interesting descending motor tract that contains both excitatory and inhibitory ...The remodeling of axonal connections following injury is an important feature driving functional recovery.The reticulospinal tract is an interesting descending motor tract that contains both excitatory and inhibitory fibers.While the reticulospinal tract has been shown to be particularly prone to axonal growth and plasticity following injuries of the spinal cord,the differential capacities of excitatory and inhibitory fibers for plasticity remain unclear.As adaptive axonal plasticity involves a sophisticated interplay between excitatory and inhibitory input,we investigated in this study the plastic potential of glutamatergic(vGlut2)and GABAergic(vGat)fibers originating from the gigantocellular nucleus and the lateral paragigantocellular nucleus,two nuclei important for locomotor function.Using a combination of viral tracing,chemogenetic silencing,and AI-based kinematic analysis,we investigated plasticity and its impact on functional recovery within the first 3 weeks following injury,a period prone to neuronal remodeling.We demonstrate that,in this time frame,while vGlut2-positive fibers within the gigantocellular and lateral paragigantocellular nuclei rewire significantly following cervical spinal cord injury,vGat-positive fibers are rather unresponsive to injury.We also show that the acute silencing of excitatory axonal fibers which rewire in response to lesions of the spinal cord triggers a worsening of the functional recovery.Using kinematic analysis,we also pinpoint the locomotion features associated with the gigantocellular nucleus or lateral paragigantocellular nucleus during functional recovery.Overall,our study increases the understanding of the role of the gigantocellular and lateral paragigantocellular nuclei during functional recovery following spinal cord injury.展开更多
3-D rigid visco-plastic finite element method (FEM) is used in the analysisof metal forming processes, including strip and plate rolling, shape rolling, slab edging, specialstrip rolling. The shifted incomplete Choles...3-D rigid visco-plastic finite element method (FEM) is used in the analysisof metal forming processes, including strip and plate rolling, shape rolling, slab edging, specialstrip rolling. The shifted incomplete Cholesky decomposition of the stiffness matrix with thesolution of the equations for velocity increment by the conjugate gradient method is combined. Thistechnique, termed the shifted ICCG method, is then employed to solve the slab edging problem. Theperformance of this algorithm in terms of the number of iterations, friction variation, shiftedparameter psi and the results of simulation for processing parameters are analysed. Numerical testsand application of this technique verify the efficiency and stability of the shifted ICCG method inthe analysis of slab edging.展开更多
Cross-wedge rolling (CWR) is a metal process of ro ta ry forming. To produce a part, one cylindrical billet should be placed between t wo counterrotating and wedge-shape dies, which move tangentially relative each oth...Cross-wedge rolling (CWR) is a metal process of ro ta ry forming. To produce a part, one cylindrical billet should be placed between t wo counterrotating and wedge-shape dies, which move tangentially relative each other. The billet suffers plastic deformation (essentially, localized compressio n) during its rotation between the rotating dies. Compared to other numerical si mulation methods, the finite element method (FEM) has advantages in solving gene ral problems with complex shapes of the formed parts. In cross-wedge rolling, t here are four stages in the workpiece deformation process, namely knifing, guidi ng, stretching and sizing stage. It is time-consuming and expensive to design t he CWR process by trial and error method. The application of numerical simul ation for the CWR process will help engineers to efficiently improve the process development. Tselikov, Hayama, Jain and Kobayashi, and Higashimo applied the sl ip-line theory in study of CWR process analysis. Zb.pater studied CWR process i ncluding upsetting by upper-bound method. The above numerical simulation were b ased on the two-dimensional plain-strain assumption ignored the metal flow in workpiece axial direction. Therefore, the complex three-dimensional stress and deformation involved in CWR processes were not presented. Compared to other nume rical simulation methods, the finite element method (FEM) has advantages in solv ing general problems with complex shapes of the formed parts. As yet, a few 3-D finite element simulation studies on CWR process have been reported in literatu res. In this paper, the process of cross wedge rolling (CWR) has been simulated and analyzed by 3D rigid-plastic finite element method. Considering the charact eristic of CWR, the static implicit FEM program is selected. The models proposed in this study uses the commercial code DEFORM 3D to simulate the CWR process. T his is an implicit Lagrangian finite element code, which includes many new enhan cements functions. A new method of utilizing multiple processors using the MPI s tandard has been implemented. Automatic switching between the two different defo rmation solvers (Sparse Solver and Conjugate Gradient Solver) has also been impl emented in order to increase the speed of simulations. In this paper, all stages in CWR process are simulated to be able to closely understand and analyze the a ctual CWR process. For simulating all forming stages in CWR process, the dynam ic adaptive remeshing technology for tetrahedral solid elements was applied. T he stress distributions in cross section of forming workpiece are analyzed to in terpret fracture or rarefaction in the center of workpiece. Authors also analyze d the time-torque curve and the laws of load changing.展开更多
The squeeze flow of a rigid-plastic medium between parallel disks is considered for small gaps with partial wall slip. The stress distribution and the squeeze force between parallel disks of a rigid-plastic medium wit...The squeeze flow of a rigid-plastic medium between parallel disks is considered for small gaps with partial wall slip. The stress distribution and the squeeze force between parallel disks of a rigid-plastic medium with the following four diferent slip boundary conditions are obtained. (1) The Coulombic friction condition is applied, and the stress distribution on the wall is derived, which is linear or exponential distribution in the no-slip area or slip area. (2) It is assumed that the slip velocity at the disks increases linearly with the radius up to the rim slip velocity, with the stress distribution and the squeeze force gained. (3) The assumption that the slip velocity at the disks is related to the shear stress component is used, with the stress distribution and the squeeze force obtained, which is equivalent to the result given in (2). (4) Rational velocity components are introduced, and the stress distribution is satisfed.展开更多
Water-blown polyurethane rigid foams are getting more and more attention,because the traditional blowing agent HCFC141b has already been abolished to prevent the ozone layer from destruction.However,the polyurethane r...Water-blown polyurethane rigid foams are getting more and more attention,because the traditional blowing agent HCFC141b has already been abolished to prevent the ozone layer from destruction.However,the polyurethane rigid foams blown by water have serious defects,i.e.friability and resulting lower adhesion strength.Thus,the purpose of this study is to resolve the problems by chemical plastication.The maleate was added to polyol-premix containing water or to polyisocyanate,with both of which maleate does not react.To prove the reaction when polyol-premix and polyisocyanate were mixed,the model composite was synthesized and analyzed by IR,NMR and ESI(MS).Furthermore,a series of water-blown polyurethane rigid foams added different amount maleate were successfully prepared.By testing impact strength and adhesion strength of the foams,the actual effect of adding maleate was obtained.展开更多
The rigid, perfectly plastic dynamic response of a free-free beam subjected to impact by a projectile at any cross-section is studied. The instantaneous deformations of the beam are given through an analysis of the ...The rigid, perfectly plastic dynamic response of a free-free beam subjected to impact by a projectile at any cross-section is studied. The instantaneous deformations of the beam are given through an analysis of the complete solution for rigid plastic structures. The in?uence of some parameters such as the input energy and mass ratio on the plastic deformation, travelling plastic hinge position and energy partitioning of the beam are discussed.展开更多
Under the hypothesis of the rigid-plastic material, specific efforts are placed on the developments of the key simulation techniques of the meshless Galerkin method because of the complexity of the deformation process...Under the hypothesis of the rigid-plastic material, specific efforts are placed on the developments of the key simulation techniques of the meshless Galerkin method because of the complexity of the deformation process as well as the generality and atomization of the simulation procedures for non-steady state large deformation plastic processes, therefore, an adaptive rigid meshless Galerkin method is developed. The influence domain control method is used in the least square approximation by dynamic evaluation of the magnitude of the influence domain and the effective control of the amount and the positions of the points in the least square approximation in order to improve approximation precision. The amount of the Gauss integration points in the discrete domain is maintained in a considerable magnitude in order to ensure the integration precision in the discrete domain. The length of the frictional boundary of the plastic deformation process may be getting longer when its deforma- tion is getting severe. Thus, the densities of the boundary points of some places get lower. The adaptive boundary points setting method is employed to improve the approximation precision of the boundary points and enhance the constraint of the boundary condition by adaptive control of boundary point density. Some typical extrusion processes are analyzed, detail simulation results such as the deformation field, velocity field, effective strain field, effective strain rate field, the volume loss curve and load-stroke curve are obtained. The effectiveness of the method developed is demonstrated and the precision of the meshless simulation is proved by overall comparison with the results obtained by using the commercial software deform.展开更多
By using the energy criterion in [3], the impact torsional buckling for the rigid plastic cylindrical shell is studied. The linear dynamic torsional buckling equations for the rigid plastic shell is drived, and the cr...By using the energy criterion in [3], the impact torsional buckling for the rigid plastic cylindrical shell is studied. The linear dynamic torsional buckling equations for the rigid plastic shell is drived, and the critical impact velocity is given.展开更多
A new method of three-dimensional remeshing is proposed for rigid-plastic finiteelement analysis of a complicated forging process.The forging process of a cylindricalhousing has been simulated to show the effectivenes...A new method of three-dimensional remeshing is proposed for rigid-plastic finiteelement analysis of a complicated forging process.The forging process of a cylindricalhousing has been simulated to show the effectiveness of the scheme.The result ofsimulation shows that the computation can be effectively carried out by using the des-cribed remeshing scheme.展开更多
Based on synthetically considering the coupled thermo mechanical relations between temperature and deforming, a numerical simulation of the forging process for the special long cone shaped workpiece of Al 5.44Mg 2...Based on synthetically considering the coupled thermo mechanical relations between temperature and deforming, a numerical simulation of the forging process for the special long cone shaped workpiece of Al 5.44Mg 2.15Li 0.12Zr alloy at high temperature was conducted by using the rigid visco plastic finite element method. The relations between the total load and the displacement during the forging, and the distributions of stress, strain, temperature and strain rate, which can provide useful information for the process design, are obtained.展开更多
A study is presented for the large deflection dynamic response of rigid- plastic circular plate resting on potential fluid under a rectangular pressure pulse load. By virtue of Hankel integral transform technique,this...A study is presented for the large deflection dynamic response of rigid- plastic circular plate resting on potential fluid under a rectangular pressure pulse load. By virtue of Hankel integral transform technique,this interaction problem is reduced to a problem of dynamic plastic response of the plate in vacuum.The closed-form solutions are derived for both middle and high pressure loads by solving the equations of motion with the large deflection in the range where both bending moments and membrane forces are important.Some numerical results are given.展开更多
Applications of certain multi-parameter acceleration techniques used with themodified New-ton-Raphson (mN-R) methods to solve the nonlinear equations arising from rigid-plasticfinite element analysis are investigated....Applications of certain multi-parameter acceleration techniques used with themodified New-ton-Raphson (mN-R) methods to solve the nonlinear equations arising from rigid-plasticfinite element analysis are investigated. New modified multi-parameter techniques, developed fromCrisfield's multi-parameter methods, are utilized to solve these nonlinear equations. The numericalperformance of these techniques is compared with the standard Newton-Raphson method (sN-R),Crisfield's single parameter method (C1), Crisfield's two parameter method (C2) and Crisfield'sthree parameter method (C3). The new techniques do not involve additional residual force calculationand require little extra computational effort. In addition, they are more robust and efficient thanother existing acceleration techniques.展开更多
文摘Compared with the traditional rigid plastic/rigid viscoplastic(RP/RVP) FEM(based on iteration solution),RP/RVP FEM based on linear programming (LP) has some remarkable advantages,such as it's free of convergence problem and its convenience in contact,rigid zone,and friction force treatment.The numerical model of RP/RVP FEM based on LP for axisymmetrical metal forming simulation is studied,and some related key factors and its treatment methods in formulation of constraint condition are proposed.Some solution examples are provided to validate its accuracy and efficiency.
文摘A new rigid-plastic/rigid-viscoplastic (RP/RVP) FEM based on linearprogramming (LP) for plane-strain metal forming simulation is proposed. Compared with thetraditional RP/RVP FEM based on iteration solution, it has some remarkable advantages, such a it'sfree of convergence problem and its convenience in contact, incompressibility constraint and rigidzone treatment. Two solution examples are provided to validate its accuracy and efficiency.
基金financially supported by King Abdulaziz University,Deanship of Scientific Research(DSR)。
文摘Neuronal plasticity,the brain's ability to adapt structurally and functionally,is essential for learning,memory,and recovery from injuries.In neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease,this plasticity is disrupted,leading to cognitive and motor deficits.This review explores the mechanisms of neuronal plasticity and its effect on Alzheimer's disease and Parkinson's disease.Alzheimer's disease features amyloid-beta plaques and tau tangles that impair synaptic function,while Parkinson's disease involves the loss of dopaminergic neurons affecting motor control.Enhancing neuronal plasticity offers therapeutic potential for these diseases.A systematic literature review was conducted using databases such as PubMed,Scopus,and Google Scholar,focusing on studies of neuronal plasticity in Alzheimer's disease and Parkinson's disease.Data synthesis identified key themes such as synaptic mechanisms,neurogenesis,and therapeutic strategies,linking molecular insights to clinical applications.Results highlight that targeting synaptic plasticity mechanisms,such as long-term potentiation and long-term depression,shows promise.Neurotrophic factors,advanced imaging techniques,and molecular tools(e.g.,clustered regularly interspaced short palindromic repeats and optogenetics)are crucial in understanding and enhancing plasticity.Current therapies,including dopamine replacement,deep brain stimulation,and lifestyle interventions,demonstrate the potential to alleviate symptoms and improve outcomes.In conclusion,enhancing neuronal plasticity through targeted therapies holds significant promise for treating neurodegenerative diseases.Future research should integrate multidisciplinary approaches to fully harness the therapeutic potential of neuronal plasticity in Alzheimer's disease and Parkinson's disease.
基金funded by the Alexander von Humboldt Stiftungsupported by DFG (SCH W534/6-1 to SWS)
文摘The dentate gyrus of the hippocampus is a plastic structure that displays modifications at different levels in response to positive stimuli as well as to negative conditions such as brain damage.The latter involves global alterations,making understanding plastic responses triggered by local damage difficult.One key feature of the dentate gyrus is that it contains a well-defined neurogenic niche,the subgranular zone,and beyond neurogenesis,newly born granule cells may maintain a“young”phenotype throughout life,adding to the plastic nature of the structure.Here,we present a novel experimental model of local brain damage in organotypic entorhino-hippocampal cultures that results in the activation of adjacent newly born granule cells.A small piece of filter paper was placed on the surface of the granule cell layer of the dentate gyrus,which evoked a foreign body reaction of astrocytes,along with the activation of local young neurons expressing doublecortin.Forty-eight hours after foreign body placement,the number of doublecortin-immunoreactive cells increased in the subgranular zone in the direct vicinity of the foreign body,whereas overall increased doublecortin immunoreactivity was observed in the granule cell layer and molecular layer of the dentate gyrus.Foreign body placement in the pyramidal layer of the CA1 region evoked a comparable local astroglial reaction but did not lead to an increase in doublecortin-immunoreactive in either the CA1 region or the adjacent dentate gyrus.Seven days after foreign body placement in the dentate gyrus,the increase in doublecortin-immunoreactivity was no longer observed,indicating the transient activation of young cells.However,7 days after foreign body placement,the number of doublecortin-immunoreactive granule cells coimmunoreactive for calbindin was lower than that under the control conditions.As calbindin is a marker for mature granule cells,this result suggests that activated young cells remain at a more immature stage following foreign body placement.Live imaging of retrovirally green fluorescent protein-labeled newly born granule cells revealed the orientation and growth of their dendrites toward the foreign body placement.This novel experimental model of foreign body placement in organotypic entorhino-hippocampal cultures could serve as a valuable tool for studying both glial reactivity and neuronal plasticity,specifically of newly born neurons under controlled in vitro conditions.
基金supported financially by the National Natural Science Foundation of China(No.52172208)Taishan Scholar Young Talent Program(No.tsqn202306216)Shandong Excellent Young Scientists Fund Program(Overseas,2023HWYQ‑091).
文摘Oxygen reduction reaction(ORR)is crucial for Znair batteries,while also serves as a core electrochemical process in oxygen depolarized cathodes(ODCs)for chlor-alkali electrolysis.The lack of cost-effective,highly active ORR electrocatalysts with superior kinetics hinders progress in this field.Herein,we report the Fe/Ni dual single-atomic sites anchored by commercial carbon black(Fe/Ni-N/CB)using rigid ligand confined and high-temperature shock(HTS)strategy in less than 0.5 s.Theoretical calculation reveals that singleatomic Fe is the real active site.Single-atomic Fe and Ni species in Fe/Ni-N/CB synergistically accelerate the kinetics of ORR by reducing the energy barrier of the rate-determining step.A large half-wave potential(E_(1/2))of 0.907 V is achieved in 0.1 M KOH aqueous solution.The assembled aqueous Zn-air battery(A-ZAB)with Fe/Ni-N/CB cathode presents remarkable charge-discharge cycling stability for over 650 h without voltage gap degradation.The quasi-solid-state Zn-air battery(QSS-ZAB)exhibits excellent reversibility over a 150-h operation at 0.5 mA·cm^(-2) with negligible energy conversion efficiency recession.Impressively,Fe/Ni-N/CB||RuO_(2)chloralkali flow cell exhibits a low cell voltage of 1.60 V at a large current density of 300 mA·cm^(-2) at 80℃,and demonstrates exceptional durability with 7% current density decay over 150 h of continuous operation at 100 mA·cm^(-2).Fe/Ni-N/CB||RuO_(2)achieves near-ideal caustic current efficiency(~97.2%)at the current density of 300 mA·cm^(-2).This work provides a rapid and economical synthesis technique for the synthesis of catalysts at the atomic scale while demonstrating significant potential for application in energy-saving chlor-alkali electrolyzer.
基金supported by Progetto Trapezio,Compagnia di San Paolo(67935-2021.2174),to LBFondazione CRT(Cassa di Risparmio di Torino,RF=2022.0618),to LBPRIN2022(grant 2022LB4X3N),to LB。
文摘The capacity of the central nervous system for structural plasticity and regeneration is commonly believed to show a decreasing progression from“small and simple”brains to the larger,more complex brains of mammals.However,recent findings revealed that some forms of neural plasticity can show a reverse trend.Although plasticity is a well-preserved,transversal feature across the animal world,a variety of cell populations and mechanisms seem to have evolved to enable structural modifications to take place in widely different brains,likely as adaptations to selective pressures.Increasing evidence now indicates that a trade-off has occurred between regenerative(mostly stem cell–driven)plasticity and developmental(mostly juvenile)remodeling,with the latter primarily aimed not at brain repair but rather at“sculpting”the neural circuits based on experience.In particular,an evolutionary trade-off has occurred between neurogenic processes intended to support the possibility of recruiting new neurons throughout life and the different ways of obtaining new neurons,and between the different brain locations in which plasticity occurs.This review first briefly surveys the different types of plasticity and the complexity of their possible outcomes and then focuses on recent findings showing that the mammalian brain has a stem cell–independent integration of new neurons into pre-existing(mature)neural circuits.This process is still largely unknown but involves neuronal cells that have been blocked in arrested maturation since their embryonic origin(also termed“immature”or“dormant”neurons).These cells can then restart maturation throughout the animal's lifespan to become functional neurons in brain regions,such as the cerebral cortex and amygdala,that are relevant to high-order cognition and emotions.Unlike stem cell–driven postnatal/adult neurogenesis,which significantly decreases from small-brained,short-living species to large-brained ones,immature neurons are particularly abundant in large-brained,long-living mammals,including humans.The immature neural cell populations hosted in these complex brains are an interesting example of an“enlarged road”in the phylogenetic trend of plastic potential decreases commonly observed in the animal world.The topic of dormant neurons that covary with brain size and gyrencephaly represents a prospective turning point in the field of neuroplasticity,with important translational outcomes.These cells can represent a reservoir of undifferentiated neurons,potentially granting plasticity within the high-order circuits subserving the most sophisticated cognitive skills that are important in the growing brains of young,healthy individuals and are frequently affected by debilitating neurodevelopmental and degenerative disorders.
文摘Regenerative capacity of the central nervous system(CNS)is unevenly distributed among vertebrates.While most mammalian species including humans elicit limited repair following CNS injury or disease,highly regenerative vertebrates including urodele amphibians and teleost fish spontaneously reverse CNS damage.Teletost zebrafish(danio rerio)are tropical freshwater fish that proved to be an excellent vertebrate model of successful CNS regeneration.Differential neuronal,glial,and immune injury responses underlie disparate injury outcomes between highly regenerative zebrafish and poorly regenerative mammals.This article describes complications associated with neuronal repair following spinal cord injury(SCI)in poorly regenerative mammals and highlights intersecting modes of plasticity and regeneration in highly regenerative zebrafish(Figures 1 and 2).Comparative approaches evaluating immunoglial SCI responses were recently reviewed elsewhere(Reyes and Mokalled,2024).
基金supported by the Deutsche Forschungsgemeinschaft(DFG),TRR274(Project ID 408885537,Sy Nergy,EXC 2145/ID 390857198,to FMB)。
文摘The remodeling of axonal connections following injury is an important feature driving functional recovery.The reticulospinal tract is an interesting descending motor tract that contains both excitatory and inhibitory fibers.While the reticulospinal tract has been shown to be particularly prone to axonal growth and plasticity following injuries of the spinal cord,the differential capacities of excitatory and inhibitory fibers for plasticity remain unclear.As adaptive axonal plasticity involves a sophisticated interplay between excitatory and inhibitory input,we investigated in this study the plastic potential of glutamatergic(vGlut2)and GABAergic(vGat)fibers originating from the gigantocellular nucleus and the lateral paragigantocellular nucleus,two nuclei important for locomotor function.Using a combination of viral tracing,chemogenetic silencing,and AI-based kinematic analysis,we investigated plasticity and its impact on functional recovery within the first 3 weeks following injury,a period prone to neuronal remodeling.We demonstrate that,in this time frame,while vGlut2-positive fibers within the gigantocellular and lateral paragigantocellular nuclei rewire significantly following cervical spinal cord injury,vGat-positive fibers are rather unresponsive to injury.We also show that the acute silencing of excitatory axonal fibers which rewire in response to lesions of the spinal cord triggers a worsening of the functional recovery.Using kinematic analysis,we also pinpoint the locomotion features associated with the gigantocellular nucleus or lateral paragigantocellular nucleus during functional recovery.Overall,our study increases the understanding of the role of the gigantocellular and lateral paragigantocellular nuclei during functional recovery following spinal cord injury.
基金supported by Huo Yingdong Young Teachers Foundation,Ministry of State Education of ChinaNational Natural Science Foundation of China(No.59904003).
文摘3-D rigid visco-plastic finite element method (FEM) is used in the analysisof metal forming processes, including strip and plate rolling, shape rolling, slab edging, specialstrip rolling. The shifted incomplete Cholesky decomposition of the stiffness matrix with thesolution of the equations for velocity increment by the conjugate gradient method is combined. Thistechnique, termed the shifted ICCG method, is then employed to solve the slab edging problem. Theperformance of this algorithm in terms of the number of iterations, friction variation, shiftedparameter psi and the results of simulation for processing parameters are analysed. Numerical testsand application of this technique verify the efficiency and stability of the shifted ICCG method inthe analysis of slab edging.
文摘Cross-wedge rolling (CWR) is a metal process of ro ta ry forming. To produce a part, one cylindrical billet should be placed between t wo counterrotating and wedge-shape dies, which move tangentially relative each other. The billet suffers plastic deformation (essentially, localized compressio n) during its rotation between the rotating dies. Compared to other numerical si mulation methods, the finite element method (FEM) has advantages in solving gene ral problems with complex shapes of the formed parts. In cross-wedge rolling, t here are four stages in the workpiece deformation process, namely knifing, guidi ng, stretching and sizing stage. It is time-consuming and expensive to design t he CWR process by trial and error method. The application of numerical simul ation for the CWR process will help engineers to efficiently improve the process development. Tselikov, Hayama, Jain and Kobayashi, and Higashimo applied the sl ip-line theory in study of CWR process analysis. Zb.pater studied CWR process i ncluding upsetting by upper-bound method. The above numerical simulation were b ased on the two-dimensional plain-strain assumption ignored the metal flow in workpiece axial direction. Therefore, the complex three-dimensional stress and deformation involved in CWR processes were not presented. Compared to other nume rical simulation methods, the finite element method (FEM) has advantages in solv ing general problems with complex shapes of the formed parts. As yet, a few 3-D finite element simulation studies on CWR process have been reported in literatu res. In this paper, the process of cross wedge rolling (CWR) has been simulated and analyzed by 3D rigid-plastic finite element method. Considering the charact eristic of CWR, the static implicit FEM program is selected. The models proposed in this study uses the commercial code DEFORM 3D to simulate the CWR process. T his is an implicit Lagrangian finite element code, which includes many new enhan cements functions. A new method of utilizing multiple processors using the MPI s tandard has been implemented. Automatic switching between the two different defo rmation solvers (Sparse Solver and Conjugate Gradient Solver) has also been impl emented in order to increase the speed of simulations. In this paper, all stages in CWR process are simulated to be able to closely understand and analyze the a ctual CWR process. For simulating all forming stages in CWR process, the dynam ic adaptive remeshing technology for tetrahedral solid elements was applied. T he stress distributions in cross section of forming workpiece are analyzed to in terpret fracture or rarefaction in the center of workpiece. Authors also analyze d the time-torque curve and the laws of load changing.
基金Project supported by the National Natural Science Foundation of China(No.10372113).
文摘The squeeze flow of a rigid-plastic medium between parallel disks is considered for small gaps with partial wall slip. The stress distribution and the squeeze force between parallel disks of a rigid-plastic medium with the following four diferent slip boundary conditions are obtained. (1) The Coulombic friction condition is applied, and the stress distribution on the wall is derived, which is linear or exponential distribution in the no-slip area or slip area. (2) It is assumed that the slip velocity at the disks increases linearly with the radius up to the rim slip velocity, with the stress distribution and the squeeze force gained. (3) The assumption that the slip velocity at the disks is related to the shear stress component is used, with the stress distribution and the squeeze force obtained, which is equivalent to the result given in (2). (4) Rational velocity components are introduced, and the stress distribution is satisfed.
文摘Water-blown polyurethane rigid foams are getting more and more attention,because the traditional blowing agent HCFC141b has already been abolished to prevent the ozone layer from destruction.However,the polyurethane rigid foams blown by water have serious defects,i.e.friability and resulting lower adhesion strength.Thus,the purpose of this study is to resolve the problems by chemical plastication.The maleate was added to polyol-premix containing water or to polyisocyanate,with both of which maleate does not react.To prove the reaction when polyol-premix and polyisocyanate were mixed,the model composite was synthesized and analyzed by IR,NMR and ESI(MS).Furthermore,a series of water-blown polyurethane rigid foams added different amount maleate were successfully prepared.By testing impact strength and adhesion strength of the foams,the actual effect of adding maleate was obtained.
基金Project supported by the National Natural Science Foundation of China (No.10272011).
文摘The rigid, perfectly plastic dynamic response of a free-free beam subjected to impact by a projectile at any cross-section is studied. The instantaneous deformations of the beam are given through an analysis of the complete solution for rigid plastic structures. The in?uence of some parameters such as the input energy and mass ratio on the plastic deformation, travelling plastic hinge position and energy partitioning of the beam are discussed.
基金This project is supported by National Natural Science Foundation for Dis-tiguished Young Scholars of China (No. 50425517).
文摘Under the hypothesis of the rigid-plastic material, specific efforts are placed on the developments of the key simulation techniques of the meshless Galerkin method because of the complexity of the deformation process as well as the generality and atomization of the simulation procedures for non-steady state large deformation plastic processes, therefore, an adaptive rigid meshless Galerkin method is developed. The influence domain control method is used in the least square approximation by dynamic evaluation of the magnitude of the influence domain and the effective control of the amount and the positions of the points in the least square approximation in order to improve approximation precision. The amount of the Gauss integration points in the discrete domain is maintained in a considerable magnitude in order to ensure the integration precision in the discrete domain. The length of the frictional boundary of the plastic deformation process may be getting longer when its deforma- tion is getting severe. Thus, the densities of the boundary points of some places get lower. The adaptive boundary points setting method is employed to improve the approximation precision of the boundary points and enhance the constraint of the boundary condition by adaptive control of boundary point density. Some typical extrusion processes are analyzed, detail simulation results such as the deformation field, velocity field, effective strain field, effective strain rate field, the volume loss curve and load-stroke curve are obtained. The effectiveness of the method developed is demonstrated and the precision of the meshless simulation is proved by overall comparison with the results obtained by using the commercial software deform.
基金Project supported by the National Natural Science Foundation of China
文摘By using the energy criterion in [3], the impact torsional buckling for the rigid plastic cylindrical shell is studied. The linear dynamic torsional buckling equations for the rigid plastic shell is drived, and the critical impact velocity is given.
文摘A new method of three-dimensional remeshing is proposed for rigid-plastic finiteelement analysis of a complicated forging process.The forging process of a cylindricalhousing has been simulated to show the effectiveness of the scheme.The result ofsimulation shows that the computation can be effectively carried out by using the des-cribed remeshing scheme.
文摘Based on synthetically considering the coupled thermo mechanical relations between temperature and deforming, a numerical simulation of the forging process for the special long cone shaped workpiece of Al 5.44Mg 2.15Li 0.12Zr alloy at high temperature was conducted by using the rigid visco plastic finite element method. The relations between the total load and the displacement during the forging, and the distributions of stress, strain, temperature and strain rate, which can provide useful information for the process design, are obtained.
基金The study is supported by National Natural Science Foundation of China.
文摘A study is presented for the large deflection dynamic response of rigid- plastic circular plate resting on potential fluid under a rectangular pressure pulse load. By virtue of Hankel integral transform technique,this interaction problem is reduced to a problem of dynamic plastic response of the plate in vacuum.The closed-form solutions are derived for both middle and high pressure loads by solving the equations of motion with the large deflection in the range where both bending moments and membrane forces are important.Some numerical results are given.
文摘Applications of certain multi-parameter acceleration techniques used with themodified New-ton-Raphson (mN-R) methods to solve the nonlinear equations arising from rigid-plasticfinite element analysis are investigated. New modified multi-parameter techniques, developed fromCrisfield's multi-parameter methods, are utilized to solve these nonlinear equations. The numericalperformance of these techniques is compared with the standard Newton-Raphson method (sN-R),Crisfield's single parameter method (C1), Crisfield's two parameter method (C2) and Crisfield'sthree parameter method (C3). The new techniques do not involve additional residual force calculationand require little extra computational effort. In addition, they are more robust and efficient thanother existing acceleration techniques.
