牙周炎与糖尿病存在密切的双向关联,二者通过炎症因子交互及代谢紊乱等机制相互促进。研究表明,以龈下刮治及根面平整术(scaling and root planing,SRP)为核心的牙周非手术治疗(non-surgical periodontal therapy,NSPT)不仅可以有效治...牙周炎与糖尿病存在密切的双向关联,二者通过炎症因子交互及代谢紊乱等机制相互促进。研究表明,以龈下刮治及根面平整术(scaling and root planing,SRP)为核心的牙周非手术治疗(non-surgical periodontal therapy,NSPT)不仅可以有效治疗牙周炎,还可改善糖尿病患者的血糖控制及全身炎症状态。本文综述了不同NSPT方案(包括单纯SRP、抗菌药物辅助SRP、激光治疗辅助SRP等)对糖尿病伴牙周炎患者血糖控制的改善效果。SRP可以显著降低糖化血红蛋白(hemoglobin A1c,HbA1c)水平;而抗菌药物及激光治疗的辅助则能显著提高SRP的血糖改善疗效。同时,本文重点关注NSPT改善血糖控制的潜在调控机制,包括:炎症因子介导的JNK/IKKβ信号通路激活引起胰岛素抵抗;晚期糖基化终末产物(advanced glycation end products,AGEs)介导的RAGE-ROS/NF-κB信号通路调控引起胰岛β细胞功能障碍;肠道菌群失调介导的TLR4-MyD88/TRIF信号轴引发胰岛素抵抗;牙周致病菌鞭毛蛋白引起的胰岛素分泌障碍;以及牙周致病菌脂多糖(lipopolysaccharide,LPS)导致的Th17/Treg比例失衡及其下游STAT3/SOCS3信号通路对胰岛素信号传导的抑制作用,旨在为未来糖尿病伴牙周炎患者的靶向干预及协同治疗提供新的参考。尽管现有研究揭示了NSPT的临床疗效及部分机制,但仍存在以下问题:不同NSPT方案调控血糖的具体效应分子及信号通路网络尚未系统阐明,患者个体间疗效差异明显,以及辅助疗法额外获益的长期稳定性不明。未来研究需探索更多联合治疗方案实现多疗法协同增效、深入解析机制、识别关键靶点,推动糖尿病-牙周炎联合病变的精准管理。展开更多
A series of direct numerical simulations of the fully developed plane Couette flow at a Reynolds number of 6000（based on the relative wall speed and half the channel height h） with different streamwise and spanwise ...A series of direct numerical simulations of the fully developed plane Couette flow at a Reynolds number of 6000（based on the relative wall speed and half the channel height h） with different streamwise and spanwise lengths are conducted to investigate the effects of the computational box sizes on the secondary flow（SF）. Our focuses are the number of counter-rotating vortex pairs and its relationship to the statistics of the mean flow and the SF in the small and moderate computational box sizes. Our results show that the number of vortex pairs is sensitive to the computational box size, and so are the slope parameter, the rate of the turbulent kinetic energy contributed by the SF, and the ratio of the kinetic energy of the SF to the total kinetic energy. However, the averaged spanwise width of each counter-rotating vortex pair in the plane Couette flow is found, for the first time, within 4（1 ± 0.25）h despite the domain sizes.展开更多
This paper investigates the linear stability behaviour of plane Poiseuille flow under unsteady distortion by multiscale perturbation method and discusses further the problem proposed by paper [1]. The results show tha...This paper investigates the linear stability behaviour of plane Poiseuille flow under unsteady distortion by multiscale perturbation method and discusses further the problem proposed by paper [1]. The results show that in the initial period of disturbance development, the distortion profiles presented by paper [1] will make the disturbances grow up, thus augmenting the possibility of instability.展开更多
Texture acquisition of a large scale scene is one of the critical research areas in computer vision and can be used in other application areas such as computer graphics (CG), the intelligent transportation system (ITS...Texture acquisition of a large scale scene is one of the critical research areas in computer vision and can be used in other application areas such as computer graphics (CG), the intelligent transportation system (ITS) and the 3D geographic information system (GIS). Moreover, to acquire texture without noise (e.g., a shadow, an obstacle body) is vital for such work. Although obstacles can be removed by using 3D geometric data, shadow elimination is still a difficult problem and strongly required for the CG and ITS community, especially for city modeling and simulation purposes. In this paper, we propose an automatic multiple image fusion technique and an efficient and simple shadow removing technique to retrieve high quality texture images of an urban area. The image fusion can be efficiently achieved by epipolar plane image (EPI) analysis, and the shadow elimination can be successfully carried out by an illumination independent color clustering technique. The strength of this algorithm is that we can successfully fuse multiple images and eliminate shadows from the fused single image, especially in low dynamic range images, which have proven difficult using previous techniques.展开更多
文摘牙周炎与糖尿病存在密切的双向关联,二者通过炎症因子交互及代谢紊乱等机制相互促进。研究表明,以龈下刮治及根面平整术(scaling and root planing,SRP)为核心的牙周非手术治疗(non-surgical periodontal therapy,NSPT)不仅可以有效治疗牙周炎,还可改善糖尿病患者的血糖控制及全身炎症状态。本文综述了不同NSPT方案(包括单纯SRP、抗菌药物辅助SRP、激光治疗辅助SRP等)对糖尿病伴牙周炎患者血糖控制的改善效果。SRP可以显著降低糖化血红蛋白(hemoglobin A1c,HbA1c)水平;而抗菌药物及激光治疗的辅助则能显著提高SRP的血糖改善疗效。同时,本文重点关注NSPT改善血糖控制的潜在调控机制,包括:炎症因子介导的JNK/IKKβ信号通路激活引起胰岛素抵抗;晚期糖基化终末产物(advanced glycation end products,AGEs)介导的RAGE-ROS/NF-κB信号通路调控引起胰岛β细胞功能障碍;肠道菌群失调介导的TLR4-MyD88/TRIF信号轴引发胰岛素抵抗;牙周致病菌鞭毛蛋白引起的胰岛素分泌障碍;以及牙周致病菌脂多糖(lipopolysaccharide,LPS)导致的Th17/Treg比例失衡及其下游STAT3/SOCS3信号通路对胰岛素信号传导的抑制作用,旨在为未来糖尿病伴牙周炎患者的靶向干预及协同治疗提供新的参考。尽管现有研究揭示了NSPT的临床疗效及部分机制,但仍存在以下问题:不同NSPT方案调控血糖的具体效应分子及信号通路网络尚未系统阐明,患者个体间疗效差异明显,以及辅助疗法额外获益的长期稳定性不明。未来研究需探索更多联合治疗方案实现多疗法协同增效、深入解析机制、识别关键靶点,推动糖尿病-牙周炎联合病变的精准管理。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11221061,11272013,and 11302006)
文摘A series of direct numerical simulations of the fully developed plane Couette flow at a Reynolds number of 6000（based on the relative wall speed and half the channel height h） with different streamwise and spanwise lengths are conducted to investigate the effects of the computational box sizes on the secondary flow（SF）. Our focuses are the number of counter-rotating vortex pairs and its relationship to the statistics of the mean flow and the SF in the small and moderate computational box sizes. Our results show that the number of vortex pairs is sensitive to the computational box size, and so are the slope parameter, the rate of the turbulent kinetic energy contributed by the SF, and the ratio of the kinetic energy of the SF to the total kinetic energy. However, the averaged spanwise width of each counter-rotating vortex pair in the plane Couette flow is found, for the first time, within 4（1 ± 0.25）h despite the domain sizes.
基金This work is supported by National Science Foundationthe Science Foundation of Shanghai University of Technology
文摘This paper investigates the linear stability behaviour of plane Poiseuille flow under unsteady distortion by multiscale perturbation method and discusses further the problem proposed by paper [1]. The results show that in the initial period of disturbance development, the distortion profiles presented by paper [1] will make the disturbances grow up, thus augmenting the possibility of instability.
文摘Texture acquisition of a large scale scene is one of the critical research areas in computer vision and can be used in other application areas such as computer graphics (CG), the intelligent transportation system (ITS) and the 3D geographic information system (GIS). Moreover, to acquire texture without noise (e.g., a shadow, an obstacle body) is vital for such work. Although obstacles can be removed by using 3D geometric data, shadow elimination is still a difficult problem and strongly required for the CG and ITS community, especially for city modeling and simulation purposes. In this paper, we propose an automatic multiple image fusion technique and an efficient and simple shadow removing technique to retrieve high quality texture images of an urban area. The image fusion can be efficiently achieved by epipolar plane image (EPI) analysis, and the shadow elimination can be successfully carried out by an illumination independent color clustering technique. The strength of this algorithm is that we can successfully fuse multiple images and eliminate shadows from the fused single image, especially in low dynamic range images, which have proven difficult using previous techniques.
